3ZM3A

Catalytic domain of human shp2
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
282
structure length
267
Chain Sequence
GAHMWEEFETLQYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDRDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
total genus 84
structure length 267
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2013-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 3zm3A00
1A5YA 1BZCA 4NWGA 3EB1A 1ONYA 2B4OA 2F46A 1NWEA 2BIJA 2PQ5A 1VHRA 1ZCKA 3MMJA 4S0GA 2I4GA 4ZI4A 3QCBA 1YN9A 2B4PA 1LYVA 5K9VA 2R0BA 1PA9A 2MBCA 4AZ1A 1G7GA 2CM7A 4QUMA 3O4TA 1SUGA 1C87A 1OHEA 2GP0A 1FPZA 1PTVA 4HRFA 3H2XA 1X24A 2GJTA 3V0GA 2I1YA 1BZJA 4DGXA 3F81A 4ZRTA 3CM3A 5KACA 2RF6A 3QKPA 1Q6MA 1T48A 1NO6A 1XRIA 3D9CA 1C84A 1I9TA 2ZMMA 4HJPA 2Q05A 4RI4A 3I36A 1V3AA 3MOWA 5KA9A 5BZZA 4I8NA 2BV5A 2BGEA 2Y2FA 1ZC0A 2B4UA 2PI7A 3F9AA 2QBRA 1U24A 5AWXA 1C85A 2F6ZA 4OHDA 3U96A 2GWOA 2QBQA 5KADA 1XBOA 3V0DA 1PA1A 1C88A 3S3EA 3F9BA 3OMHA 3S4OA 1C86A 2J17A 4RH9A 2QDCA 1OEMX 2Q47A 2ESBA 4WTYA 3F41A 4OHIA 1G1FA 2DXPA 3QCEA 1Q6NA 2I4HA 3NMEA 2OOQA 3ZM2A 1T4JA 5K9WA 3BM8A 2B4SA 2B07A 4QUNA 2F6FA 2H02A 2HXPA 3QCHA 3AWEA 5KA7A 5BX1A 4WU3A 2JJDA 3EAXA 2I6IA 1KAKA 1WAXA 1EENA 3EMUA 1U26A 3BLUA 2H4VA 2G59A 4NWFA 4PVGA 1I57A 1I9SA 1NL9A 3QKQA 3M4UA 2CFVA 1Q6TA 3QCLA 4D3PA 2BZLA 1P15A 4H1OA 3S4EA 1ZCLA 3D1OA 4ICZA 1OEOX 1R6HA 3GXGA 1PYNA 4HJQA 4NX8A 1ECVA 2CNGA 1OHDA 5KA4A 1QZ0A 5IBMA 3O5XA 2I75A 4WOHA 1NWLA 4GFVA 2I5XA 4RI5A 4B04A 2CNFA 2HB1A 1ZZWA 2F6WA 3ZMPA 1XM2A 2NT2A 1G1GA 1ONZA 4GE6A 3QCFA 3BRHA 3O4UA 2HY3A 4GFUA 5K24A 1JLNA 4Y14A 4J51A 1OEVA 1G4WR 2F71A 4RDDA 3PS5A 4OHLA 1G7FA 2B49A 2J16A 3SR9A 2I3RA 2H4GA 2IMGA 2VEXA 1JF7A 1YPTA 4WU2A 4KI9A 3RO1A 2AHSA 2G6ZA 3BLTA 1PXHA 2YDUA 1L8GA 1OEUA 3QCCA 1OETA 1LQFA 4YR8B 4RHGA 1EEOA 3GXHA 2HVLA 2J16B 1GWZA 3ZM1A 4TVVA 4PYHA 4RKKA 2VEUA 1NZ7A 4GRZA 2H03A 2A3KA 1YZ4A 2CNIA 2F6TA 4MBBA 4GRYA 1Q1MA 2I6PA 2P6XA 2I6MA 2SHPA 4QAHA 3D1HA 2M3VA 1Q6PA 2NT7A 3ZMQA 5MMZB 5KABA 1PTUA 3ZM0A 4IKCA 1BZHA 4YAAA 2FJMA 2AZRA 2CNEA 4ERCA 2A8BA 3I80A 1D5RA 1PTYA 4GS0A 1RXDA 2H4KA 1YGUA 5BUGA 1YTWA 2CJZA 2QCTA 1U25A 1YTNA 2NZ6A 2VEYA 5KA1A 3O4SA 4JMJA 4BPCA 1PH0A 1KAVA 2QEPA 3QCDA 3LJ8A 2CM8A 3N0AA 3S3HA 4KYQA 2QDMA 4GWFA 2HC2A 2F70A 2QBSA 3RGQA 3QCMA 3SMEA 1PTTA 5BZXA 4DGPA 2NTAA 4QBEA 4JBCA 4R0TA 1FPRA 3QCKA 1G1HA 5KA3A 2VEVA 4QAPA 4OHHA 2PSZA 1T49A 1YFOA 3D44A 3MOZA 1AAXA 2C46A 2NV5A 2QBPA 4OHEA 2E0TA 2F6YA 3V0HA 4JNBA 3CWEA 3QCGA 2F6VA 1WRMA 1WCHA 1YTSA 2I6OA 2FH7A 2HNQA 4GE2A 1YGRA 2I3UA 5J8RA 1Q6SA 5KA2A 2I4EA 1OESA 5GTJA 1XXVA 2PT0A 3D42A 2H04A 3QCNA 3S3KA 3QCJA 4BJOA 4KYRA 2P4DA 2I6JA 2QDPA 5EHRA 5EHPA 2OZ5A 4R30A 1QXKA 2OC3A 2I42A 4QBWA 4GE5A 2CM3A 5K25A 1GFYA 3RGOA 1M3GA 1FQ1A 4H34A 1C83A 4NNDA 4R0SA 3V0FA 1LARA 5KAAA 2QCJA 3B7OA 5M43A 3V0JA 1OHCA 2CMBA 2OUDA 4ZN5A 4JMKA 2B3OA 1L8KA 3EU0A 3O3LA 3EZZA 4D3RA 3D1QA 3QCIA 2HC1A 5LXQB 5KA8A 2CMCA 1J4XA 5IBSA 2Y96A 2HNPA 5I6VA 2FJNA 5HDEA 4NYHA 4D3QA 3A5KA 5K23A 1MKPA 1RPMA 3ZM3A 3ZV2A 1Q6JA 1YWFA 3S3FA 3AWGA 2VEWA 2PA5A 2ZN7A 4RH5A 5K22A 2PBNA 3F99A 1G4US 2CM2A 3V0IA 2WGPA 5KA0A 2NLKA 1XXPA 4Y2EA 2CMAA 2HCMA 3I7ZA 3AWFA 2BGDA 3A5JA 3RZ2A 2CNHA 3V0EA 1NNYA 3OLRA 4Z6BA 2C7SA
chains in the Genus database with same CATH superfamily
1A5YA 1J6UA 1BZCA 4NWGA 3EB1A 1ONYA 2B4OA 2F46A 1NWEA 2BIJA 2F00A 2Y68A 2PQ5A 1VHRA 1ZCKA 3MMJA 4S0GA 2I4GA 4ZI4A 3QCBA 1YN9A 2B4PA 1LYVA 1FGSA 2R0BA 5K9VA 1PA9A 2MBCA 4AZ1A 4C12A 1G7GA 2CM7A 4QUMA 3O4TA 1SUGA 1C87A 1OHEA 2GP0A 1FPZA 1PTVA 4HRFA 3H2XA 1X24A 2GJTA 3V0GA 3PYZA 2VOSA 2I1YA 1BZJA 4DGXA 3F81A 4ZRTA 3CM3A 2WTZA 5KACA 2RF6A 3QKPA 1Q6MA 1T48A 1NO6A 1XRIA 1GQQA 3D9CA 1C84A 1I9TA 2ZMMA 4HJPA 2XPCA 2Q05A 4RI4A 3I36A 1V3AA 3ZM6A 3MOWA 5KA9A 5BZZA 4I8NA 5A5FA 2BV5A 1O5ZA 2BGEA 2Y2FA 1ZC0A 2B4UA 2PI7A 3F9AA 2QBRA 1U24A 5AWXA 1C85A 2F6ZA 4OHDA 1W7KA 3U96A 2GWOA 2QBQA 5KADA 1XBOA 3V0DA 1PA1A 1C88A 3S3EA 3F9BA 3OMHA 3S4OA 1C86A 2J17A 1E0DA 4RH9A 2QDCA 1OEMX 2Q47A 2ESBA 4WTYA 3F41A 4OHIA 4CVLA 1G1FA 2DXPA 3QCEA 1Q6NA 2I4HA 3NMEA 2OOQA 3ZM2A 1T4JA 4CVMA 5K9WA 3BM8A 2B4SA 2B07A 4QUNA 2F6FA 2H02A 2HXPA 3QCHA 3AWEA 5KA7A 5BX1A 4WU3A 2JJDA 3EAXA 2I6IA 1KAKA 1WAXA 1EENA 3EMUA 1U26A 3BLUA 1JBWA 2H4VA 2G59A 4NWFA 4PVGA 1I57A 1I9SA 1NL9A 1P3DA 3QKQA 3M4UA 2CFVA 1Q6TA 2VTEA 3QCLA 4D3PA 2BZLA 1P15A 4H1OA 3S4EA 1ZCLA 3D1OA 4ICZA 2JFGA 2VORA 1OEOX 1R6HA 3GXGA 1PYNA 4HJQA 4NX8A 2Y1OA 1ECVA 2JFHA 2CNGA 1OHDA 3N2AA 5KA4A 1QZ0A 5IBMA 3O5XA 2I75A 4WOHA 1NWLA 4GFVA 2I5XA 4RI5A 4B04A 2CNFA 2HB1A 1ZZWA 2F6WA 4CVKA 3ZMPA 1XM2A 2NT2A 1G1GA 5A5EA 2GCBA 2WJPA 2UUPA 1ONZA 2X5OA 3QCFA 4GE6A 3BRHA 3O4UA 2HY3A 4GFUA 5K24A 1JLNA 4Y14A 4J51A 1OEVA 2GC5A 1G4WR 2F71A 4RDDA 3PS5A 4OHLA 1G7FA 2B49A 2J16A 3SR9A 2AM2A 2I3RA 2H4GA 2IMGA 2VEXA 1JF7A 1UAGA 1YPTA 4WU2A 4KI9A 3RO1A 2AHSA 2G6ZA 3BLTA 1PXHA 2YDUA 1L8GA 1OEUA 1JBVA 3QCCA 1OETA 1LQFA 4YR8B 4RHGA 1EEOA 3GXHA 2HVLA 2J16B 3LK7A 2Y66A 1GWZA 3ZM1A 4TVVA 4QF5A 4PYHA 1GQYA 4RKKA 3HN7A 2VEUA 1NZ7A 4GRZA 4UAGA 2H03A 2A3KA 1YZ4A 2CNIA 2F6TA 4MBBA 4GRYA 1Q1MA 2GCAA 1W78A 2GC6A 2I6PA 2P6XA 2I6MA 2SHPA 4QAHA 3D1HA 4C13A 2M3VA 1Q6PA 2NT7A 3ZMQA 5MMZB 4HV4A 5KABA 1PTUA 1EEHA 3ZM0A 4IKCA 1BZHA 4YAAA 2FJMA 2AZRA 2CNEA 4ERCA 2A8BA 3I80A 1D5RA 1PTYA 4GS0A 1RXDA 2H4KA 1YGUA 5BUGA 1YTWA 2CJZA 2QCTA 1U25A 1YTNA 2NZ6A 2VEYA 5KA1A 3O4SA 4JMJA 4BPCA 1PH0A 1KAVA 2QEPA 3QCDA 3LJ8A 2CM8A 3N0AA 3S3HA 4KYQA 2QDMA 4GWFA 2HC2A 2F70A 2QBSA 3RGQA 1GG4A 3QCMA 4ZIYA 3SMEA 1PTTA 5BZXA 4DGPA 2NTAA 4QBEA 4JBCA 4R0TA 1FPRA 3QCKA 1G1HA 4BUBA 5KA3A 2VEVA 4QAPA 4OHHA 2PSZA 1E8CA 1T49A 1YFOA 3D44A 3MOZA 1AAXA 2C46A 2NV5A 2QBPA 4OHEA 2E0TA 2F6YA 3V0HA 4JNBA 3CWEA 3QCGA 2F6VA 1WRMA 1WCHA 1YTSA 2I6OA 2FH7A 2HNQA 4GE2A 1YGRA 2I3UA 5J8RA 1Q6SA 5KA2A 2I4EA 1OESA 5GTJA 1XXVA 2PT0A 3D42A 2H04A 3QCNA 3S3KA 3QCJA 4BJOA 4KYRA 2P4DA 2I6JA 2QDPA 5EHRA 3ZL8A 5EHPA 2OZ5A 4R30A 1QXKA 2OC3A 2I42A 4QBWA 4GE5A 3UAGA 2CM3A 5K25A 1GFYA 3RGOA 1M3GA 1FQ1A 4H34A 1C83A 4NNDA 4R0SA 3V0FA 1LARA 2XJAA 5KAAA 3MVNA 2QCJA 3B7OA 5M43A 3V0JA 1OHCA 2CMBA 2OUDA 4ZN5A 4JMKA 2B3OA 1L8KA 3EU0A 3NRSA 3O3LA 3EZZA 4D3RA 3D1QA 2UUOA 3QCIA 3QCZA 2HC1A 5LXQB 4QDIA 5KA8A 2CMCA 1J4XA 5IBSA 2Y96A 2Y67A 2HNPA 5I6VA 2FJNA 5HDEA 4NYHA 4D3QA 3A5KA 5K23A 1MKPA 1RPMA 3ZM3A 3ZV2A 1Q6JA 1YWFA 2AM1A 3S3FA 3AWGA 2VEWA 2PA5A 2ZN7A 4RH5A 5K22A 2PBNA 3F99A 2JFFA 1G4US 2UAGA 2CM2A 3V0IA 2WGPA 5KA0A 2NLKA 1XXPA 4Y2EA 2CMAA 3ZM5A 2HCMA 3I7ZA 3AWFA 2BGDA 2VTDA 3A5JA 3RZ2A 2CNHA 3V0EA 4BUCA 1NNYA 3OLRA 4Z6BA 2C7SA 1P31A
chains in the Genus database with same CATH topology
1A5YA 1BZCA 4NWGA 3EB1A 1ONYA 2B4OA 2F46A 1NWEA 2BIJA 2PQ5A 1VHRA 1ZCKA 3MMJA 4S0GA 2I4GA 4ZI4A 3QCBA 1YN9A 2B4PA 1LYVA 5K9VA 2R0BA 1PA9A 2MBCA 4AZ1A 1G7GA 2CM7A 4QUMA 3O4TA 1SUGA 1C87A 1OHEA 2GP0A 1FPZA 1PTVA 4HRFA 3H2XA 1X24A 2GJTA 3V0GA 2I1YA 1BZJA 4DGXA 3F81A 4ZRTA 3CM3A 5KACA 2RF6A 3QKPA 1Q6MA 1T48A 1NO6A 1XRIA 3D9CA 1C84A 1I9TA 2ZMMA 4HJPA 2Q05A 4RI4A 3I36A 1V3AA 3MOWA 5KA9A 5BZZA 4I8NA 2BV5A 2BGEA 2Y2FA 1ZC0A 2B4UA 2PI7A 3F9AA 2QBRA 1U24A 5AWXA 1C85A 2F6ZA 4OHDA 3U96A 2GWOA 2QBQA 5KADA 1XBOA 3V0DA 1PA1A 1C88A 3S3EA 3F9BA 3OMHA 3S4OA 1C86A 2J17A 4RH9A 2QDCA 1OEMX 2Q47A 2ESBA 4WTYA 3F41A 4OHIA 1G1FA 2DXPA 3QCEA 1Q6NA 2I4HA 3NMEA 2OOQA 3ZM2A 1T4JA 5K9WA 3BM8A 2B4SA 2B07A 4QUNA 2F6FA 2H02A 2HXPA 3QCHA 3AWEA 5KA7A 5BX1A 4WU3A 2JJDA 3EAXA 2I6IA 1KAKA 1WAXA 1EENA 3EMUA 1U26A 3BLUA 2H4VA 2G59A 4NWFA 4PVGA 1I57A 1I9SA 1NL9A 3QKQA 3M4UA 2CFVA 1Q6TA 3QCLA 4D3PA 2BZLA 1P15A 4H1OA 3S4EA 1ZCLA 3D1OA 4ICZA 1OEOX 1R6HA 3GXGA 1PYNA 4HJQA 4NX8A 1ECVA 2CNGA 1OHDA 5KA4A 1QZ0A 5IBMA 3O5XA 2I75A 4WOHA 1NWLA 4GFVA 2I5XA 4RI5A 4B04A 2CNFA 2HB1A 1ZZWA 2F6WA 3ZMPA 1XM2A 2NT2A 1G1GA 1ONZA 4GE6A 3QCFA 3BRHA 3O4UA 2HY3A 4GFUA 5K24A 1JLNA 4Y14A 4J51A 1OEVA 1G4WR 2F71A 4RDDA 3PS5A 4OHLA 1G7FA 2B49A 2J16A 3SR9A 2I3RA 2H4GA 2IMGA 2VEXA 1JF7A 1YPTA 4WU2A 4KI9A 3RO1A 2AHSA 2G6ZA 3BLTA 1PXHA 2YDUA 1L8GA 1OEUA 3QCCA 1OETA 1LQFA 4YR8B 4RHGA 1EEOA 3GXHA 2HVLA 2J16B 1GWZA 3ZM1A 4TVVA 4PYHA 4RKKA 2VEUA 1NZ7A 4GRZA 2H03A 2A3KA 1YZ4A 2CNIA 2F6TA 4MBBA 4GRYA 1Q1MA 2I6PA 2P6XA 2I6MA 2SHPA 4QAHA 3D1HA 2M3VA 1Q6PA 2NT7A 3ZMQA 5MMZB 5KABA 1PTUA 3ZM0A 4IKCA 1BZHA 4YAAA 2FJMA 2AZRA 2CNEA 4ERCA 2A8BA 3I80A 1D5RA 1PTYA 4GS0A 1RXDA 2H4KA 1YGUA 5BUGA 1YTWA 2CJZA 2QCTA 1U25A 1YTNA 2NZ6A 2VEYA 5KA1A 3O4SA 4JMJA 4BPCA 1PH0A 1KAVA 2QEPA 3QCDA 3LJ8A 2CM8A 3N0AA 3S3HA 4KYQA 2QDMA 4GWFA 2HC2A 2F70A 2QBSA 3RGQA 3QCMA 3SMEA 1PTTA 5BZXA 4DGPA 2NTAA 4QBEA 4JBCA 4R0TA 1FPRA 3QCKA 1G1HA 5KA3A 2VEVA 4QAPA 4OHHA 2PSZA 1T49A 1YFOA 3D44A 3MOZA 1AAXA 2C46A 2NV5A 2QBPA 4OHEA 2E0TA 2F6YA 3V0HA 4JNBA 3CWEA 3QCGA 2F6VA 1WRMA 1WCHA 1YTSA 2I6OA 2FH7A 2HNQA 4GE2A 1YGRA 2I3UA 5J8RA 1Q6SA 5KA2A 2I4EA 1OESA 5GTJA 1XXVA 2PT0A 3D42A 2H04A 3QCNA 3S3KA 3QCJA 4BJOA 4KYRA 2P4DA 2I6JA 2QDPA 5EHRA 5EHPA 2OZ5A 4R30A 1QXKA 2OC3A 2I42A 4QBWA 4GE5A 2CM3A 5K25A 1GFYA 3RGOA 1M3GA 1FQ1A 4H34A 1C83A 4NNDA 4R0SA 3V0FA 1LARA 5KAAA 2QCJA 3B7OA 5M43A 3V0JA 1OHCA 2CMBA 2OUDA 4ZN5A 4JMKA 2B3OA 1L8KA 3EU0A 3O3LA 3EZZA 4D3RA 3D1QA 3QCIA 2HC1A 5LXQB 5KA8A 2CMCA 1J4XA 5IBSA 2Y96A 2HNPA 5I6VA 2FJNA 5HDEA 4NYHA 4D3QA 3A5KA 5K23A 1MKPA 1RPMA 3ZM3A 3ZV2A 1Q6JA 1YWFA 3S3FA 3AWGA 2VEWA 2PA5A 2ZN7A 4RH5A 5K22A 2PBNA 3F99A 1G4US 2CM2A 3V0IA 2WGPA 5KA0A 2NLKA 1XXPA 4Y2EA 2CMAA 2HCMA 3I7ZA 3AWFA 2BGDA 3A5JA 3RZ2A 2CNHA 3V0EA 1NNYA 3OLRA 4Z6BA 2C7SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A5Y A;  1BZC A;  4NWG A;  3EB1 A;  1ONY A;  2B4O A;  2F46 A;  1NWE A;  2BIJ A;  2PQ5 A;  1VHR A;  1ZCK A;  3MMJ A;  4S0G A;  2I4G A;  4ZI4 A;  3QCB A;  1YN9 A;  2B4P A;  1LYV A;  5K9V A;  2R0B A;  1PA9 A;  2MBC A;  4AZ1 A;  1G7G A;  2CM7 A;  4QUM A;  3O4T A;  1SUG A;  1C87 A;  1OHE A;  2GP0 A;  1FPZ A;  1PTV A;  4HRF A;  3H2X A;  1X24 A;  2GJT A;  3V0G A;  2I1Y A;  1BZJ A;  4DGX A;  3F81 A;  4ZRT A;  3CM3 A;  5KAC A;  2RF6 A;  3QKP A;  1Q6M A;  1T48 A;  1NO6 A;  1XRI A;  3D9C A;  1C84 A;  1I9T A;  2ZMM A;  4HJP A;  2Q05 A;  4RI4 A;  3I36 A;  1V3A A;  3MOW A;  5KA9 A;  5BZZ A;  4I8N A;  2BV5 A;  2BGE A;  2Y2F A;  1ZC0 A;  2B4U A;  2PI7 A;  3F9A A;  2QBR A;  1U24 A;  5AWX A;  1C85 A;  2F6Z A;  4OHD A;  3U96 A;  2GWO A;  2QBQ A;  5KAD A;  1XBO A;  3V0D A;  1PA1 A;  1C88 A;  3S3E A;  3F9B A;  3OMH A;  3S4O A;  1C86 A;  2J17 A;  4RH9 A;  2QDC A;  1OEM X;  2Q47 A;  2ESB A;  4WTY A;  3F41 A;  4OHI A;  1G1F A;  2DXP A;  3QCE A;  1Q6N A;  2I4H A;  3NME A;  2OOQ A;  3ZM2 A;  1T4J A;  5K9W A;  3BM8 A;  2B4S A;  2B07 A;  4QUN A;  2F6F A;  2H02 A;  2HXP A;  3QCH A;  3AWE A;  5KA7 A;  5BX1 A;  4WU3 A;  2JJD A;  3EAX A;  2I6I A;  1KAK A;  1WAX A;  1EEN A;  3EMU A;  1U26 A;  3BLU A;  2H4V A;  2G59 A;  4NWF A;  4PVG A;  1I57 A;  1I9S A;  1NL9 A;  3QKQ A;  3M4U A;  2CFV A;  1Q6T A;  3QCL A;  4D3P A;  2BZL A;  1P15 A;  4H1O A;  3S4E A;  1ZCL A;  3D1O A;  4ICZ A;  1OEO X;  1R6H A;  3GXG A;  1PYN A;  4HJQ A;  4NX8 A;  1ECV A;  2CNG A;  1OHD A;  5KA4 A;  1QZ0 A;  5IBM A;  3O5X A;  2I75 A;  4WOH A;  1NWL A;  4GFV A;  2I5X A;  4RI5 A;  4B04 A;  2CNF A;  2HB1 A;  1ZZW A;  2F6W A;  3ZMP A;  1XM2 A;  2NT2 A;  1G1G A;  1ONZ A;  4GE6 A;  3QCF A;  3BRH A;  3O4U A;  2HY3 A;  4GFU A;  5K24 A;  1JLN A;  4Y14 A;  4J51 A;  1OEV A;  1G4W R;  2F71 A;  4RDD A;  3PS5 A;  4OHL A;  1G7F A;  2B49 A;  2J16 A;  3SR9 A;  2I3R A;  2H4G A;  2IMG A;  2VEX A;  1JF7 A;  1YPT A;  4WU2 A;  4KI9 A;  3RO1 A;  2AHS A;  2G6Z A;  3BLT A;  1PXH A;  2YDU A;  1L8G A;  1OEU A;  3QCC A;  1OET A;  1LQF A;  4YR8 B;  4RHG A;  1EEO A;  3GXH A;  2HVL A;  2J16 B;  1GWZ A;  3ZM1 A;  4TVV A;  4PYH A;  4RKK A;  2VEU A;  1NZ7 A;  4GRZ A;  2H03 A;  2A3K A;  1YZ4 A;  2CNI A;  2F6T A;  4MBB A;  4GRY A;  1Q1M A;  2I6P A;  2P6X A;  2I6M A;  2SHP A;  4QAH A;  3D1H A;  2M3V A;  1Q6P A;  2NT7 A;  3ZMQ A;  5MMZ B;  5KAB A;  1PTU A;  3ZM0 A;  4IKC A;  1BZH A;  4YAA A;  2FJM A;  2AZR A;  2CNE A;  4ERC A;  2A8B A;  3I80 A;  1D5R A;  1PTY A;  4GS0 A;  1RXD A;  2H4K A;  1YGU A;  5BUG A;  1YTW A;  2CJZ A;  2QCT A;  1U25 A;  1YTN A;  2NZ6 A;  2VEY A;  5KA1 A;  3O4S A;  4JMJ A;  4BPC A;  1PH0 A;  1KAV A;  2QEP A;  3QCD A;  3LJ8 A;  2CM8 A;  3N0A A;  3S3H A;  4KYQ A;  2QDM A;  4GWF A;  2HC2 A;  2F70 A;  2QBS A;  3RGQ A;  3QCM A;  3SME A;  1PTT A;  5BZX A;  4DGP A;  2NTA A;  4QBE A;  4JBC A;  4R0T A;  1FPR A;  3QCK A;  1G1H A;  5KA3 A;  2VEV A;  4QAP A;  4OHH A;  2PSZ A;  1T49 A;  1YFO A;  3D44 A;  3MOZ A;  1AAX A;  2C46 A;  2NV5 A;  2QBP A;  4OHE A;  2E0T A;  2F6Y A;  3V0H A;  4JNB A;  3CWE A;  3QCG A;  2F6V A;  1WRM A;  1WCH A;  1YTS A;  2I6O A;  2FH7 A;  2HNQ A;  4GE2 A;  1YGR A;  2I3U A;  5J8R A;  1Q6S A;  5KA2 A;  2I4E A;  1OES A;  5GTJ A;  1XXV A;  2PT0 A;  3D42 A;  2H04 A;  3QCN A;  3S3K A;  3QCJ A;  4BJO A;  4KYR A;  2P4D A;  2I6J A;  2QDP A;  5EHR A;  5EHP A;  2OZ5 A;  4R30 A;  1QXK A;  2OC3 A;  2I42 A;  4QBW A;  4GE5 A;  2CM3 A;  5K25 A;  1GFY A;  3RGO A;  1M3G A;  1FQ1 A;  4H34 A;  1C83 A;  4NND A;  4R0S A;  3V0F A;  1LAR A;  5KAA A;  2QCJ A;  3B7O A;  5M43 A;  3V0J A;  1OHC A;  2CMB A;  2OUD A;  4ZN5 A;  4JMK A;  2B3O A;  1L8K A;  3EU0 A;  3O3L A;  3EZZ A;  4D3R A;  3D1Q A;  3QCI A;  2HC1 A;  5LXQ B;  5KA8 A;  2CMC A;  1J4X A;  5IBS A;  2Y96 A;  2HNP A;  5I6V A;  2FJN A;  5HDE A;  4NYH A;  4D3Q A;  3A5K A;  5K23 A;  1MKP A;  1RPM A;  3ZM3 A;  3ZV2 A;  1Q6J A;  1YWF A;  3S3F A;  3AWG A;  2VEW A;  2PA5 A;  2ZN7 A;  4RH5 A;  5K22 A;  2PBN A;  3F99 A;  1G4U S;  2CM2 A;  3V0I A;  2WGP A;  5KA0 A;  2NLK A;  1XXP A;  4Y2E A;  2CMA A;  2HCM A;  3I7Z A;  3AWF A;  2BGD A;  3A5J A;  3RZ2 A;  2CNH A;  3V0E A;  1NNY A;  3OLR A;  4Z6B A;  2C7S A; 
#chains in the Genus database with same CATH topology
 1A5Y A;  1J6U A;  1BZC A;  4NWG A;  3EB1 A;  1ONY A;  2B4O A;  2F46 A;  1NWE A;  2BIJ A;  2F00 A;  2Y68 A;  2PQ5 A;  1VHR A;  1ZCK A;  3MMJ A;  4S0G A;  2I4G A;  4ZI4 A;  3QCB A;  1YN9 A;  2B4P A;  1LYV A;  1FGS A;  2R0B A;  5K9V A;  1PA9 A;  2MBC A;  4AZ1 A;  4C12 A;  1G7G A;  2CM7 A;  4QUM A;  3O4T A;  1SUG A;  1C87 A;  1OHE A;  2GP0 A;  1FPZ A;  1PTV A;  4HRF A;  3H2X A;  1X24 A;  2GJT A;  3V0G A;  3PYZ A;  2VOS A;  2I1Y A;  1BZJ A;  4DGX A;  3F81 A;  4ZRT A;  3CM3 A;  2WTZ A;  5KAC A;  2RF6 A;  3QKP A;  1Q6M A;  1T48 A;  1NO6 A;  1XRI A;  1GQQ A;  3D9C A;  1C84 A;  1I9T A;  2ZMM A;  4HJP A;  2XPC A;  2Q05 A;  4RI4 A;  3I36 A;  1V3A A;  3ZM6 A;  3MOW A;  5KA9 A;  5BZZ A;  4I8N A;  5A5F A;  2BV5 A;  1O5Z A;  2BGE A;  2Y2F A;  1ZC0 A;  2B4U A;  2PI7 A;  3F9A A;  2QBR A;  1U24 A;  5AWX A;  1C85 A;  2F6Z A;  4OHD A;  1W7K A;  3U96 A;  2GWO A;  2QBQ A;  5KAD A;  1XBO A;  3V0D A;  1PA1 A;  1C88 A;  3S3E A;  3F9B A;  3OMH A;  3S4O A;  1C86 A;  2J17 A;  1E0D A;  4RH9 A;  2QDC A;  1OEM X;  2Q47 A;  2ESB A;  4WTY A;  3F41 A;  4OHI A;  4CVL A;  1G1F A;  2DXP A;  3QCE A;  1Q6N A;  2I4H A;  3NME A;  2OOQ A;  3ZM2 A;  1T4J A;  4CVM A;  5K9W A;  3BM8 A;  2B4S A;  2B07 A;  4QUN A;  2F6F A;  2H02 A;  2HXP A;  3QCH A;  3AWE A;  5KA7 A;  5BX1 A;  4WU3 A;  2JJD A;  3EAX A;  2I6I A;  1KAK A;  1WAX A;  1EEN A;  3EMU A;  1U26 A;  3BLU A;  1JBW A;  2H4V A;  2G59 A;  4NWF A;  4PVG A;  1I57 A;  1I9S A;  1NL9 A;  1P3D A;  3QKQ A;  3M4U A;  2CFV A;  1Q6T A;  2VTE A;  3QCL A;  4D3P A;  2BZL A;  1P15 A;  4H1O A;  3S4E A;  1ZCL A;  3D1O A;  4ICZ A;  2JFG A;  2VOR A;  1OEO X;  1R6H A;  3GXG A;  1PYN A;  4HJQ A;  4NX8 A;  2Y1O A;  1ECV A;  2JFH A;  2CNG A;  1OHD A;  3N2A A;  5KA4 A;  1QZ0 A;  5IBM A;  3O5X A;  2I75 A;  4WOH A;  1NWL A;  4GFV A;  2I5X A;  4RI5 A;  4B04 A;  2CNF A;  2HB1 A;  1ZZW A;  2F6W A;  4CVK A;  3ZMP A;  1XM2 A;  2NT2 A;  1G1G A;  5A5E A;  2GCB A;  2WJP A;  2UUP A;  1ONZ A;  2X5O A;  3QCF A;  4GE6 A;  3BRH A;  3O4U A;  2HY3 A;  4GFU A;  5K24 A;  1JLN A;  4Y14 A;  4J51 A;  1OEV A;  2GC5 A;  1G4W R;  2F71 A;  4RDD A;  3PS5 A;  4OHL A;  1G7F A;  2B49 A;  2J16 A;  3SR9 A;  2AM2 A;  2I3R A;  2H4G A;  2IMG A;  2VEX A;  1JF7 A;  1UAG A;  1YPT A;  4WU2 A;  4KI9 A;  3RO1 A;  2AHS A;  2G6Z A;  3BLT A;  1PXH A;  2YDU A;  1L8G A;  1OEU A;  1JBV A;  3QCC A;  1OET A;  1LQF A;  4YR8 B;  4RHG A;  1EEO A;  3GXH A;  2HVL A;  2J16 B;  3LK7 A;  2Y66 A;  1GWZ A;  3ZM1 A;  4TVV A;  4QF5 A;  4PYH A;  1GQY A;  4RKK A;  3HN7 A;  2VEU A;  1NZ7 A;  4GRZ A;  4UAG A;  2H03 A;  2A3K A;  1YZ4 A;  2CNI A;  2F6T A;  4MBB A;  4GRY A;  1Q1M A;  2GCA A;  1W78 A;  2GC6 A;  2I6P A;  2P6X A;  2I6M A;  2SHP A;  4QAH A;  3D1H A;  4C13 A;  2M3V A;  1Q6P A;  2NT7 A;  3ZMQ A;  5MMZ B;  4HV4 A;  5KAB A;  1PTU A;  1EEH A;  3ZM0 A;  4IKC A;  1BZH A;  4YAA A;  2FJM A;  2AZR A;  2CNE A;  4ERC A;  2A8B A;  3I80 A;  1D5R A;  1PTY A;  4GS0 A;  1RXD A;  2H4K A;  1YGU A;  5BUG A;  1YTW A;  2CJZ A;  2QCT A;  1U25 A;  1YTN A;  2NZ6 A;  2VEY A;  5KA1 A;  3O4S A;  4JMJ A;  4BPC A;  1PH0 A;  1KAV A;  2QEP A;  3QCD A;  3LJ8 A;  2CM8 A;  3N0A A;  3S3H A;  4KYQ A;  2QDM A;  4GWF A;  2HC2 A;  2F70 A;  2QBS A;  3RGQ A;  1GG4 A;  3QCM A;  4ZIY A;  3SME A;  1PTT A;  5BZX A;  4DGP A;  2NTA A;  4QBE A;  4JBC A;  4R0T A;  1FPR A;  3QCK A;  1G1H A;  4BUB A;  5KA3 A;  2VEV A;  4QAP A;  4OHH A;  2PSZ A;  1E8C A;  1T49 A;  1YFO A;  3D44 A;  3MOZ A;  1AAX A;  2C46 A;  2NV5 A;  2QBP A;  4OHE A;  2E0T A;  2F6Y A;  3V0H A;  4JNB A;  3CWE A;  3QCG A;  2F6V A;  1WRM A;  1WCH A;  1YTS A;  2I6O A;  2FH7 A;  2HNQ A;  4GE2 A;  1YGR A;  2I3U A;  5J8R A;  1Q6S A;  5KA2 A;  2I4E A;  1OES A;  5GTJ A;  1XXV A;  2PT0 A;  3D42 A;  2H04 A;  3QCN A;  3S3K A;  3QCJ A;  4BJO A;  4KYR A;  2P4D A;  2I6J A;  2QDP A;  5EHR A;  3ZL8 A;  5EHP A;  2OZ5 A;  4R30 A;  1QXK A;  2OC3 A;  2I42 A;  4QBW A;  4GE5 A;  3UAG A;  2CM3 A;  5K25 A;  1GFY A;  3RGO A;  1M3G A;  1FQ1 A;  4H34 A;  1C83 A;  4NND A;  4R0S A;  3V0F A;  1LAR A;  2XJA A;  5KAA A;  3MVN A;  2QCJ A;  3B7O A;  5M43 A;  3V0J A;  1OHC A;  2CMB A;  2OUD A;  4ZN5 A;  4JMK A;  2B3O A;  1L8K A;  3EU0 A;  3NRS A;  3O3L A;  3EZZ A;  4D3R A;  3D1Q A;  2UUO A;  3QCI A;  3QCZ A;  2HC1 A;  5LXQ B;  4QDI A;  5KA8 A;  2CMC A;  1J4X A;  5IBS A;  2Y96 A;  2Y67 A;  2HNP A;  5I6V A;  2FJN A;  5HDE A;  4NYH A;  4D3Q A;  3A5K A;  5K23 A;  1MKP A;  1RPM A;  3ZM3 A;  3ZV2 A;  1Q6J A;  1YWF A;  2AM1 A;  3S3F A;  3AWG A;  2VEW A;  2PA5 A;  2ZN7 A;  4RH5 A;  5K22 A;  2PBN A;  3F99 A;  2JFF A;  1G4U S;  2UAG A;  2CM2 A;  3V0I A;  2WGP A;  5KA0 A;  2NLK A;  1XXP A;  4Y2E A;  2CMA A;  3ZM5 A;  2HCM A;  3I7Z A;  3AWF A;  2BGD A;  2VTD A;  3A5J A;  3RZ2 A;  2CNH A;  3V0E A;  4BUC A;  1NNY A;  3OLR A;  4Z6B A;  2C7S A;  1P31 A; 
#chains in the Genus database with same CATH homology
 1A5Y A;  1BZC A;  4NWG A;  3EB1 A;  1ONY A;  2B4O A;  2F46 A;  1NWE A;  2BIJ A;  2PQ5 A;  1VHR A;  1ZCK A;  3MMJ A;  4S0G A;  2I4G A;  4ZI4 A;  3QCB A;  1YN9 A;  2B4P A;  1LYV A;  5K9V A;  2R0B A;  1PA9 A;  2MBC A;  4AZ1 A;  1G7G A;  2CM7 A;  4QUM A;  3O4T A;  1SUG A;  1C87 A;  1OHE A;  2GP0 A;  1FPZ A;  1PTV A;  4HRF A;  3H2X A;  1X24 A;  2GJT A;  3V0G A;  2I1Y A;  1BZJ A;  4DGX A;  3F81 A;  4ZRT A;  3CM3 A;  5KAC A;  2RF6 A;  3QKP A;  1Q6M A;  1T48 A;  1NO6 A;  1XRI A;  3D9C A;  1C84 A;  1I9T A;  2ZMM A;  4HJP A;  2Q05 A;  4RI4 A;  3I36 A;  1V3A A;  3MOW A;  5KA9 A;  5BZZ A;  4I8N A;  2BV5 A;  2BGE A;  2Y2F A;  1ZC0 A;  2B4U A;  2PI7 A;  3F9A A;  2QBR A;  1U24 A;  5AWX A;  1C85 A;  2F6Z A;  4OHD A;  3U96 A;  2GWO A;  2QBQ A;  5KAD A;  1XBO A;  3V0D A;  1PA1 A;  1C88 A;  3S3E A;  3F9B A;  3OMH A;  3S4O A;  1C86 A;  2J17 A;  4RH9 A;  2QDC A;  1OEM X;  2Q47 A;  2ESB A;  4WTY A;  3F41 A;  4OHI A;  1G1F A;  2DXP A;  3QCE A;  1Q6N A;  2I4H A;  3NME A;  2OOQ A;  3ZM2 A;  1T4J A;  5K9W A;  3BM8 A;  2B4S A;  2B07 A;  4QUN A;  2F6F A;  2H02 A;  2HXP A;  3QCH A;  3AWE A;  5KA7 A;  5BX1 A;  4WU3 A;  2JJD A;  3EAX A;  2I6I A;  1KAK A;  1WAX A;  1EEN A;  3EMU A;  1U26 A;  3BLU A;  2H4V A;  2G59 A;  4NWF A;  4PVG A;  1I57 A;  1I9S A;  1NL9 A;  3QKQ A;  3M4U A;  2CFV A;  1Q6T A;  3QCL A;  4D3P A;  2BZL A;  1P15 A;  4H1O A;  3S4E A;  1ZCL A;  3D1O A;  4ICZ A;  1OEO X;  1R6H A;  3GXG A;  1PYN A;  4HJQ A;  4NX8 A;  1ECV A;  2CNG A;  1OHD A;  5KA4 A;  1QZ0 A;  5IBM A;  3O5X A;  2I75 A;  4WOH A;  1NWL A;  4GFV A;  2I5X A;  4RI5 A;  4B04 A;  2CNF A;  2HB1 A;  1ZZW A;  2F6W A;  3ZMP A;  1XM2 A;  2NT2 A;  1G1G A;  1ONZ A;  4GE6 A;  3QCF A;  3BRH A;  3O4U A;  2HY3 A;  4GFU A;  5K24 A;  1JLN A;  4Y14 A;  4J51 A;  1OEV A;  1G4W R;  2F71 A;  4RDD A;  3PS5 A;  4OHL A;  1G7F A;  2B49 A;  2J16 A;  3SR9 A;  2I3R A;  2H4G A;  2IMG A;  2VEX A;  1JF7 A;  1YPT A;  4WU2 A;  4KI9 A;  3RO1 A;  2AHS A;  2G6Z A;  3BLT A;  1PXH A;  2YDU A;  1L8G A;  1OEU A;  3QCC A;  1OET A;  1LQF A;  4YR8 B;  4RHG A;  1EEO A;  3GXH A;  2HVL A;  2J16 B;  1GWZ A;  3ZM1 A;  4TVV A;  4PYH A;  4RKK A;  2VEU A;  1NZ7 A;  4GRZ A;  2H03 A;  2A3K A;  1YZ4 A;  2CNI A;  2F6T A;  4MBB A;  4GRY A;  1Q1M A;  2I6P A;  2P6X A;  2I6M A;  2SHP A;  4QAH A;  3D1H A;  2M3V A;  1Q6P A;  2NT7 A;  3ZMQ A;  5MMZ B;  5KAB A;  1PTU A;  3ZM0 A;  4IKC A;  1BZH A;  4YAA A;  2FJM A;  2AZR A;  2CNE A;  4ERC A;  2A8B A;  3I80 A;  1D5R A;  1PTY A;  4GS0 A;  1RXD A;  2H4K A;  1YGU A;  5BUG A;  1YTW A;  2CJZ A;  2QCT A;  1U25 A;  1YTN A;  2NZ6 A;  2VEY A;  5KA1 A;  3O4S A;  4JMJ A;  4BPC A;  1PH0 A;  1KAV A;  2QEP A;  3QCD A;  3LJ8 A;  2CM8 A;  3N0A A;  3S3H A;  4KYQ A;  2QDM A;  4GWF A;  2HC2 A;  2F70 A;  2QBS A;  3RGQ A;  3QCM A;  3SME A;  1PTT A;  5BZX A;  4DGP A;  2NTA A;  4QBE A;  4JBC A;  4R0T A;  1FPR A;  3QCK A;  1G1H A;  5KA3 A;  2VEV A;  4QAP A;  4OHH A;  2PSZ A;  1T49 A;  1YFO A;  3D44 A;  3MOZ A;  1AAX A;  2C46 A;  2NV5 A;  2QBP A;  4OHE A;  2E0T A;  2F6Y A;  3V0H A;  4JNB A;  3CWE A;  3QCG A;  2F6V A;  1WRM A;  1WCH A;  1YTS A;  2I6O A;  2FH7 A;  2HNQ A;  4GE2 A;  1YGR A;  2I3U A;  5J8R A;  1Q6S A;  5KA2 A;  2I4E A;  1OES A;  5GTJ A;  1XXV A;  2PT0 A;  3D42 A;  2H04 A;  3QCN A;  3S3K A;  3QCJ A;  4BJO A;  4KYR A;  2P4D A;  2I6J A;  2QDP A;  5EHR A;  5EHP A;  2OZ5 A;  4R30 A;  1QXK A;  2OC3 A;  2I42 A;  4QBW A;  4GE5 A;  2CM3 A;  5K25 A;  1GFY A;  3RGO A;  1M3G A;  1FQ1 A;  4H34 A;  1C83 A;  4NND A;  4R0S A;  3V0F A;  1LAR A;  5KAA A;  2QCJ A;  3B7O A;  5M43 A;  3V0J A;  1OHC A;  2CMB A;  2OUD A;  4ZN5 A;  4JMK A;  2B3O A;  1L8K A;  3EU0 A;  3O3L A;  3EZZ A;  4D3R A;  3D1Q A;  3QCI A;  2HC1 A;  5LXQ B;  5KA8 A;  2CMC A;  1J4X A;  5IBS A;  2Y96 A;  2HNP A;  5I6V A;  2FJN A;  5HDE A;  4NYH A;  4D3Q A;  3A5K A;  5K23 A;  1MKP A;  1RPM A;  3ZM3 A;  3ZV2 A;  1Q6J A;  1YWF A;  3S3F A;  3AWG A;  2VEW A;  2PA5 A;  2ZN7 A;  4RH5 A;  5K22 A;  2PBN A;  3F99 A;  1G4U S;  2CM2 A;  3V0I A;  2WGP A;  5KA0 A;  2NLK A;  1XXP A;  4Y2E A;  2CMA A;  2HCM A;  3I7Z A;  3AWF A;  2BGD A;  3A5J A;  3RZ2 A;  2CNH A;  3V0E A;  1NNY A;  3OLR A;  4Z6B A;  2C7S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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