5K4MA

Directed evolutionary changes in mbl super family - ndm-1 round 10 crystal-3
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
228
structure length
228
Chain Sequence
DQRFGDPVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLMVDTAGTDAQTAQILKWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPREGVVAAQHSLTFAATGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIRDSKAKSLGNLDEADTEHYAASVRAFGAAFPKASMIVMSHFAPDSRAAITHTARMADKLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Enzyme evolvability is contingent on the initial sequence background
rcsb
source organism Klebsiella pneumoniae
molecule tags Hydrolase
molecule keywords Metallo-beta-lactamase type 2
total genus 73
structure length 228
sequence length 228
ec nomenclature ec 3.5.2.6: Beta-lactamase.
pdb deposition date 2016-05-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00753 Lactamase_B Metallo-beta-lactamase superfamily
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase; Chain A Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 5k4mA00
1VMEA 2GCUA 4TZEA 4C1HA 3ESHA 3TP9A 3I11A 2BG8B 3T3NA 3LVZA 4BP0A 1XM8A 4YSLA 5DPXA 4Z67A 3VPEA 2P18A 4WD6A 4ZNBA 1YCHA 1K07A 3IE0A 2BG7A 1ZKPA 5KILA 1Y44A 3QH8A 2OHHA 4Z7RA 5EVKA 2BC2A 3SRXA 2XF4A 5B3RA 3X2XA 2BGAA 3PY6A 5HIQA 4DIKA 2UYXA 3SPUA 2FK6A 2QINA 3Q6VA 3H3EA 3AF5A 2YNVA 4C1CA 1P9EA 5IQKA 3RKKA 1KO2A 5K4KA 3FCZA 5ACVA 4H0DA 5K0WA 3ZNBA 1DXKA 3L6NA 4UBQA 3G1PA 2Q42A 3SD9A 2QDSA 2Q0IA 2FM6A 2BR6A 2P4ZA 2BG2A 2FU7A 2FHXA 1L9YA 4AD9A 4NQ4A 2BG8A 2Y87A 4EYLA 4RAWA 2ZWRA 3WXCA 5ACWA 2OHIA 4J5HA 2Y8BA 2HB9A 4TZBA 2BFLA 4NQ2A 4FSBA 5A87A 5LSCA 5ACUA 2YNVB 2BIBA 3IDZA 4NQ5A 1BVTA 1HLKA 5AHOA 2YZ3A 4D1VA 4HL2A 2BFZA 2GKLA 3SW3A 4PVOA 5AYAA 1VGNA 4TYFA 5HISA 2NYPA 2WYMC 4HL1A 5EH9A 2GFJA 2NZFA 1X8HA 3A4YA 4RAMA 2AIOA 4JO0A 3IOGA 2WYLA 1KR3A 1VJNA 5EWAA 5FQCA 4RL2A 3IEMA 2Q9UA 4UWRB 5HH4A 2QDTA 2BFZB 2OHJA 3RPCA 1JJTA 3KL7A 2FU6A 3I14A 5KIKA 5HH6A 5LE1A 4PVTA 4CHLA 2P1EA 4ZEJA 2ZO4A 4UAMA 4UA4A 2YNUA 3I13A 4FEKA 1WRAA 4TYTA 2WYMA 2BFKA 3SBLA 3FAIA 5HIOA 2NZEA 4NQ6A 5LCAA 3AJ3A 2E7YA 1A8TA 1M2XA 2M5CA 5ACRA 5K4MA 4YSBA 4ZO2A 1BMCA 2BTNA 1ZNBA 4UWSB 2XR1A 1DD6A 2FHXB 4BZ3A 3X2ZA 4B87A 1MQOA 5B1UA 1DDKA 2QEDA 3SFPA 4AWYB 4F6ZA 2FU8A 2GFKA 3IELA 3R2UA 5ACQA 3AF6A 5LCFA 4V0HA 3JXPA 1YCFA 3T3OA 4EXSA 4TZ9A 1YCGA 4GYQA 3X2YA 5FQBA 5EV6A 1JT1A 3BV6A 2I7XA 4EFZA 3ZQ4A 4C1EA 1WW1A 5AXRA 5LLDA 2R2DA 3X30A 2NXAA 5HIPA 2A7MA 4P62A 3P2UA 1E5DA 1SMLA 4J5FA 3VQZA 2YCBA 4TZFA 2M5DA 5AHRA 3F9OA 3PG4A 1QH3A 2YNTA 2BG6A 2DOOA 4XUKA 4F6HA 1QH5A 5ACTA 3ADRA 2CBNA 3BK1A 2I7TA 4UWOB 2VW8A 4AX1B 3ZR9A 4C1DA 5LMCA 4D1UA 1ZTCA 3BC2A 4AX0B 5ACSA 4EYBA 4U4LA 4UWPB 4EYFA 3I15A 3RKJA 3BK2A 4DILA 4XWWA 5A0TA 3ZWFA 4RBSA 5LCHA 4LE6A 4GCWA 2DKFA 1KO3A 2WHGA 5LS3A 3DHCA 3DH8A 3IEKA 4KEPA 3DHAA 5ACXA 4Z60A 1BC2A 5AXOA 3I0VA 4YSKA 1A7TA 5B15A 5K4NA 2YNTB 3IE1A 5EVBA 5EW0A 5ACPA 2Y8AA 2ZZIA 2FU9A 1XTOA 1WUPA 4Z6XA 4RL0A 4C1FA 3KNRA 3IE2A 4D02A 3T9MA 3DHBA 5AEBA 4C1GA 5HH5A 2QJSA 5FQAA 4EY2A 4ZO3A 4AWZA 5A0VA 4C09A 2Q0JA 4HKYA 3S0ZA 1X8GA 3IOFA 4FR7A 2P97A 1JJEA 2H6AA 4RM5A 2ZNBA 5EV8A 3MD7A 5EHTA 4Z5ZA 1WUOA 4EXYA 4KEQA 4XWTA 2AZ4A 2WRSA 4D1WA 5EVDA 2I7VA 4GYUA 4D1TA 3PY5A 1X8IA 4O98A 5A5ZA 5LM6A 4Z5YA 2GMNA 2BMIA 3KNSA 2YNWA
chains in the Genus database with same CATH superfamily
1VMEA 2GCUA 4TZEA 4C1HA 3ESHA 3TP9A 3I11A 2BG8B 3T3NA 3LVZA 4BP0A 1XM8A 4YSLA 5DPXA 4Z67A 3VPEA 2P18A 4WD6A 4ZNBA 1YCHA 1K07A 3IE0A 2BG7A 1ZKPA 5KILA 1Y44A 3QH8A 2OHHA 4Z7RA 5EVKA 2BC2A 3SRXA 2XF4A 5B3RA 3X2XA 2BGAA 3PY6A 5HIQA 4DIKA 2UYXA 3SPUA 2FK6A 2QINA 3Q6VA 3H3EA 3AF5A 2YNVA 5A23A 4C1CA 1P9EA 5IQKA 3RKKA 1KO2A 5K4KA 3FCZA 5ACVA 4H0DA 5K0WA 3ZNBA 1DXKA 3L6NA 4UBQA 3G1PA 2Q42A 3SD9A 2QDSA 2Q0IA 2FM6A 2BR6A 2P4ZA 2BG2A 2FU7A 2FHXA 1L9YA 4AD9A 4NQ4A 2BG8A 2Y87A 4EYLA 4RAWA 2ZWRA 3WXCA 5ACWA 2OHIA 4AV7A 4J5HA 2Y8BA 2HB9A 4TZBA 2BFLA 4NQ2A 4FSBA 5A87A 5LSCA 5ACUA 2YNVB 2BIBA 3IDZA 4NQ5A 1BVTA 1HLKA 5AHOA 2YZ3A 4D1VA 4HL2A 2BFZA 2GKLA 3SW3A 4PVOA 5AYAA 1VGNA 4TYFA 5HISA 2NYPA 2WYMC 4HL1A 5EH9A 2GFJA 2NZFA 1X8HA 3A4YA 4RAMA 2AIOA 4NURA 4JO0A 3IOGA 2WYLA 1KR3A 1VJNA 5EWAA 5FQCA 4RL2A 3IEMA 2Q9UA 4UWRB 5HH4A 2QDTA 2BFZB 2OHJA 3RPCA 1JJTA 3KL7A 2FU6A 3I14A 5KIKA 5HH6A 5LE1A 4PVTA 4CHLA 2P1EA 4ZEJA 2ZO4A 4UAMA 4UA4A 2YNUA 3I13A 4FEKA 1WRAA 4TYTA 2WYMA 2BFKA 3SBLA 3FAIA 4AXHA 5HIOA 2NZEA 4NQ6A 5LCAA 3AJ3A 2E7YA 1A8TA 1M2XA 2M5CA 5ACRA 5K4MA 4YSBA 4ZO2A 1BMCA 2BTNA 1ZNBA 4UWSB 2XR1A 1DD6A 2FHXB 4BZ3A 3X2ZA 4B87A 1MQOA 5B1UA 1DDKA 2QEDA 3SFPA 4AWYB 4F6ZA 2FU8A 2GFKA 3IELA 3R2UA 2YHEA 5ACQA 3AF6A 5LCFA 4V0HA 3JXPA 1YCFA 3T3OA 4EXSA 4TZ9A 1YCGA 4GYQA 3X2YA 5FQBA 5EV6A 1JT1A 3BV6A 2I7XA 4EFZA 3ZQ4A 4C1EA 1WW1A 5AXRA 5LLDA 2R2DA 3X30A 2NXAA 4PDXA 5HIPA 2A7MA 4P62A 2CG3A 3P2UA 1E5DA 1SMLA 4J5FA 3VQZA 2YCBA 4TZFA 2M5DA 5AHRA 3F9OA 3PG4A 1QH3A 2YNTA 2BG6A 2DOOA 4XUKA 4F6HA 1QH5A 5ACTA 3ADRA 2CBNA 3BK1A 2I7TA 4UWOB 2VW8A 5AIJA 4AX1B 3ZR9A 4C1DA 5LMCA 4D1UA 2CFUA 1ZTCA 3BC2A 4AX0B 5ACSA 4EYBA 4U4LA 4UWPB 4EYFA 3I15A 2CFZA 3RKJA 3BK2A 4DILA 4XWWA 5A0TA 3ZWFA 4RBSA 5LCHA 4LE6A 4GCWA 2DKFA 1KO3A 2WHGA 2CG2A 5LS3A 3DHCA 3DH8A 3IEKA 4KEPA 3DHAA 5ACXA 4Z60A 1BC2A 5AXOA 3I0VA 4YSKA 1A7TA 5B15A 5K4NA 2YNTB 3IE1A 5EVBA 5EW0A 5ACPA 2Y8AA 2ZZIA 2FU9A 1XTOA 1WUPA 4Z6XA 4RL0A 4C1FA 3KNRA 3IE2A 4D02A 3T9MA 3DHBA 5AEBA 4C1GA 5HH5A 2QJSA 5FQAA 4EY2A 4ZO3A 4AWZA 5A0VA 4C09A 2Q0JA 4HKYA 3S0ZA 1X8GA 5AJLA 3IOFA 4FR7A 2P97A 1JJEA 2H6AA 4RM5A 2ZNBA 5EV8A 3MD7A 5EHTA 4Z5ZA 1WUOA 4EXYA 4KEQA 4XWTA 2AZ4A 2WRSA 4D1WA 5EVDA 2I7VA 4GYUA 4D1TA 3PY5A 1X8IA 4O98A 5A5ZA 5LM6A 4Z5YA 2GMNA 2BMIA 3KNSA 2YNWA
chains in the Genus database with same CATH topology
1VMEA 2GCUA 4TZEA 4C1HA 3ESHA 3TP9A 3I11A 2BG8B 3T3NA 3LVZA 4BP0A 1XM8A 4YSLA 5DPXA 4Z67A 3VPEA 2P18A 4WD6A 4ZNBA 1YCHA 1K07A 3IE0A 2BG7A 1ZKPA 5KILA 1Y44A 3QH8A 2OHHA 4Z7RA 5EVKA 2BC2A 3SRXA 2XF4A 5B3RA 3X2XA 2BGAA 3PY6A 5HIQA 4DIKA 2UYXA 3SPUA 2FK6A 2QINA 3Q6VA 3H3EA 3AF5A 2YNVA 4C1CA 1P9EA 5IQKA 3RKKA 1KO2A 5K4KA 3FCZA 5ACVA 4H0DA 5K0WA 3ZNBA 1DXKA 3L6NA 4UBQA 3G1PA 2Q42A 3SD9A 2QDSA 2Q0IA 2FM6A 2BR6A 2P4ZA 2BG2A 2FU7A 2FHXA 1L9YA 4AD9A 4NQ4A 2BG8A 2Y87A 4EYLA 4RAWA 2ZWRA 3WXCA 5ACWA 2OHIA 4J5HA 2Y8BA 2HB9A 4TZBA 2BFLA 4NQ2A 4FSBA 5A87A 5LSCA 5ACUA 2YNVB 2BIBA 3IDZA 4NQ5A 1BVTA 1HLKA 5AHOA 2YZ3A 4D1VA 4HL2A 2BFZA 2GKLA 3SW3A 4PVOA 5AYAA 1VGNA 4TYFA 5HISA 2NYPA 2WYMC 4HL1A 5EH9A 2GFJA 2NZFA 1X8HA 3A4YA 4RAMA 2AIOA 4JO0A 3IOGA 2WYLA 1KR3A 1VJNA 5EWAA 5FQCA 4RL2A 3IEMA 2Q9UA 4UWRB 5HH4A 2QDTA 2BFZB 2OHJA 3RPCA 1JJTA 3KL7A 2FU6A 3I14A 5KIKA 5HH6A 5LE1A 4PVTA 4CHLA 2P1EA 4ZEJA 2ZO4A 4UAMA 4UA4A 2YNUA 3I13A 4FEKA 1WRAA 4TYTA 2WYMA 2BFKA 3SBLA 3FAIA 5HIOA 2NZEA 4NQ6A 5LCAA 3AJ3A 2E7YA 1A8TA 1M2XA 2M5CA 5ACRA 5K4MA 4YSBA 4ZO2A 1BMCA 2BTNA 1ZNBA 4UWSB 2XR1A 1DD6A 2FHXB 4BZ3A 3X2ZA 4B87A 1MQOA 5B1UA 1DDKA 2QEDA 3SFPA 4AWYB 4F6ZA 2FU8A 2GFKA 3IELA 3R2UA 5ACQA 3AF6A 5LCFA 4V0HA 3JXPA 1YCFA 3T3OA 4EXSA 4TZ9A 1YCGA 4GYQA 3X2YA 5FQBA 5EV6A 1JT1A 3BV6A 2I7XA 4EFZA 3ZQ4A 4C1EA 1WW1A 5AXRA 5LLDA 2R2DA 3X30A 2NXAA 5HIPA 2A7MA 4P62A 3P2UA 1E5DA 1SMLA 4J5FA 3VQZA 2YCBA 4TZFA 2M5DA 5AHRA 3F9OA 3PG4A 1QH3A 2YNTA 2BG6A 2DOOA 4XUKA 4F6HA 1QH5A 5ACTA 3ADRA 2CBNA 3BK1A 2I7TA 4UWOB 2VW8A 4AX1B 3ZR9A 4C1DA 5LMCA 4D1UA 1ZTCA 3BC2A 4AX0B 5ACSA 4EYBA 4U4LA 4UWPB 4EYFA 3I15A 3RKJA 3BK2A 4DILA 4XWWA 5A0TA 3ZWFA 4RBSA 5LCHA 4LE6A 4GCWA 2DKFA 1KO3A 2WHGA 5LS3A 3DHCA 3DH8A 3IEKA 4KEPA 3DHAA 5ACXA 4Z60A 1BC2A 5AXOA 3I0VA 4YSKA 1A7TA 5B15A 5K4NA 2YNTB 3IE1A 5EVBA 5EW0A 5ACPA 2Y8AA 2ZZIA 2FU9A 1XTOA 1WUPA 4Z6XA 4RL0A 4C1FA 3KNRA 3IE2A 4D02A 3T9MA 3DHBA 5AEBA 4C1GA 5HH5A 2QJSA 5FQAA 4EY2A 4ZO3A 4AWZA 5A0VA 4C09A 2Q0JA 4HKYA 3S0ZA 1X8GA 3IOFA 4FR7A 2P97A 1JJEA 2H6AA 4RM5A 2ZNBA 5EV8A 3MD7A 5EHTA 4Z5ZA 1WUOA 4EXYA 4KEQA 4XWTA 2AZ4A 2WRSA 4D1WA 5EVDA 2I7VA 4GYUA 4D1TA 3PY5A 1X8IA 4O98A 5A5ZA 5LM6A 4Z5YA 2GMNA 2BMIA 3KNSA 2YNWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VME A;  2GCU A;  4TZE A;  4C1H A;  3ESH A;  3TP9 A;  3I11 A;  2BG8 B;  3T3N A;  3LVZ A;  4BP0 A;  1XM8 A;  4YSL A;  5DPX A;  4Z67 A;  3VPE A;  2P18 A;  4WD6 A;  4ZNB A;  1YCH A;  1K07 A;  3IE0 A;  2BG7 A;  1ZKP A;  5KIL A;  1Y44 A;  3QH8 A;  2OHH A;  4Z7R A;  5EVK A;  2BC2 A;  3SRX A;  2XF4 A;  5B3R A;  3X2X A;  2BGA A;  3PY6 A;  5HIQ A;  4DIK A;  2UYX A;  3SPU A;  2FK6 A;  2QIN A;  3Q6V A;  3H3E A;  3AF5 A;  2YNV A;  4C1C A;  1P9E A;  5IQK A;  3RKK A;  1KO2 A;  5K4K A;  3FCZ A;  5ACV A;  4H0D A;  5K0W A;  3ZNB A;  1DXK A;  3L6N A;  4UBQ A;  3G1P A;  2Q42 A;  3SD9 A;  2QDS A;  2Q0I A;  2FM6 A;  2BR6 A;  2P4Z A;  2BG2 A;  2FU7 A;  2FHX A;  1L9Y A;  4AD9 A;  4NQ4 A;  2BG8 A;  2Y87 A;  4EYL A;  4RAW A;  2ZWR A;  3WXC A;  5ACW A;  2OHI A;  4J5H A;  2Y8B A;  2HB9 A;  4TZB A;  2BFL A;  4NQ2 A;  4FSB A;  5A87 A;  5LSC A;  5ACU A;  2YNV B;  2BIB A;  3IDZ A;  4NQ5 A;  1BVT A;  1HLK A;  5AHO A;  2YZ3 A;  4D1V A;  4HL2 A;  2BFZ A;  2GKL A;  3SW3 A;  4PVO A;  5AYA A;  1VGN A;  4TYF A;  5HIS A;  2NYP A;  2WYM C;  4HL1 A;  5EH9 A;  2GFJ A;  2NZF A;  1X8H A;  3A4Y A;  4RAM A;  2AIO A;  4JO0 A;  3IOG A;  2WYL A;  1KR3 A;  1VJN A;  5EWA A;  5FQC A;  4RL2 A;  3IEM A;  2Q9U A;  4UWR B;  5HH4 A;  2QDT A;  2BFZ B;  2OHJ A;  3RPC A;  1JJT A;  3KL7 A;  2FU6 A;  3I14 A;  5KIK A;  5HH6 A;  5LE1 A;  4PVT A;  4CHL A;  2P1E A;  4ZEJ A;  2ZO4 A;  4UAM A;  4UA4 A;  2YNU A;  3I13 A;  4FEK A;  1WRA A;  4TYT A;  2WYM A;  2BFK A;  3SBL A;  3FAI A;  5HIO A;  2NZE A;  4NQ6 A;  5LCA A;  3AJ3 A;  2E7Y A;  1A8T A;  1M2X A;  2M5C A;  5ACR A;  5K4M A;  4YSB A;  4ZO2 A;  1BMC A;  2BTN A;  1ZNB A;  4UWS B;  2XR1 A;  1DD6 A;  2FHX B;  4BZ3 A;  3X2Z A;  4B87 A;  1MQO A;  5B1U A;  1DDK A;  2QED A;  3SFP A;  4AWY B;  4F6Z A;  2FU8 A;  2GFK A;  3IEL A;  3R2U A;  5ACQ A;  3AF6 A;  5LCF A;  4V0H A;  3JXP A;  1YCF A;  3T3O A;  4EXS A;  4TZ9 A;  1YCG A;  4GYQ A;  3X2Y A;  5FQB A;  5EV6 A;  1JT1 A;  3BV6 A;  2I7X A;  4EFZ A;  3ZQ4 A;  4C1E A;  1WW1 A;  5AXR A;  5LLD A;  2R2D A;  3X30 A;  2NXA A;  5HIP A;  2A7M A;  4P62 A;  3P2U A;  1E5D A;  1SML A;  4J5F A;  3VQZ A;  2YCB A;  4TZF A;  2M5D A;  5AHR A;  3F9O A;  3PG4 A;  1QH3 A;  2YNT A;  2BG6 A;  2DOO A;  4XUK A;  4F6H A;  1QH5 A;  5ACT A;  3ADR A;  2CBN A;  3BK1 A;  2I7T A;  4UWO B;  2VW8 A;  4AX1 B;  3ZR9 A;  4C1D A;  5LMC A;  4D1U A;  1ZTC A;  3BC2 A;  4AX0 B;  5ACS A;  4EYB A;  4U4L A;  4UWP B;  4EYF A;  3I15 A;  3RKJ A;  3BK2 A;  4DIL A;  4XWW A;  5A0T A;  3ZWF A;  4RBS A;  5LCH A;  4LE6 A;  4GCW A;  2DKF A;  1KO3 A;  2WHG A;  5LS3 A;  3DHC A;  3DH8 A;  3IEK A;  4KEP A;  3DHA A;  5ACX A;  4Z60 A;  1BC2 A;  5AXO A;  3I0V A;  4YSK A;  1A7T A;  5B15 A;  5K4N A;  2YNT B;  3IE1 A;  5EVB A;  5EW0 A;  5ACP A;  2Y8A A;  2ZZI A;  2FU9 A;  1XTO A;  1WUP A;  4Z6X A;  4RL0 A;  4C1F A;  3KNR A;  3IE2 A;  4D02 A;  3T9M A;  3DHB A;  5AEB A;  4C1G A;  5HH5 A;  2QJS A;  5FQA A;  4EY2 A;  4ZO3 A;  4AWZ A;  5A0V A;  4C09 A;  2Q0J A;  4HKY A;  3S0Z A;  1X8G A;  3IOF A;  4FR7 A;  2P97 A;  1JJE A;  2H6A A;  4RM5 A;  2ZNB A;  5EV8 A;  3MD7 A;  5EHT A;  4Z5Z A;  1WUO A;  4EXY A;  4KEQ A;  4XWT A;  2AZ4 A;  2WRS A;  4D1W A;  5EVD A;  2I7V A;  4GYU A;  4D1T A;  3PY5 A;  1X8I A;  4O98 A;  5A5Z A;  5LM6 A;  4Z5Y A;  2GMN A;  2BMI A;  3KNS A;  2YNW A; 
#chains in the Genus database with same CATH topology
 1VME A;  2GCU A;  4TZE A;  4C1H A;  3ESH A;  3TP9 A;  3I11 A;  2BG8 B;  3T3N A;  3LVZ A;  4BP0 A;  1XM8 A;  4YSL A;  5DPX A;  4Z67 A;  3VPE A;  2P18 A;  4WD6 A;  4ZNB A;  1YCH A;  1K07 A;  3IE0 A;  2BG7 A;  1ZKP A;  5KIL A;  1Y44 A;  3QH8 A;  2OHH A;  4Z7R A;  5EVK A;  2BC2 A;  3SRX A;  2XF4 A;  5B3R A;  3X2X A;  2BGA A;  3PY6 A;  5HIQ A;  4DIK A;  2UYX A;  3SPU A;  2FK6 A;  2QIN A;  3Q6V A;  3H3E A;  3AF5 A;  2YNV A;  5A23 A;  4C1C A;  1P9E A;  5IQK A;  3RKK A;  1KO2 A;  5K4K A;  3FCZ A;  5ACV A;  4H0D A;  5K0W A;  3ZNB A;  1DXK A;  3L6N A;  4UBQ A;  3G1P A;  2Q42 A;  3SD9 A;  2QDS A;  2Q0I A;  2FM6 A;  2BR6 A;  2P4Z A;  2BG2 A;  2FU7 A;  2FHX A;  1L9Y A;  4AD9 A;  4NQ4 A;  2BG8 A;  2Y87 A;  4EYL A;  4RAW A;  2ZWR A;  3WXC A;  5ACW A;  2OHI A;  4AV7 A;  4J5H A;  2Y8B A;  2HB9 A;  4TZB A;  2BFL A;  4NQ2 A;  4FSB A;  5A87 A;  5LSC A;  5ACU A;  2YNV B;  2BIB A;  3IDZ A;  4NQ5 A;  1BVT A;  1HLK A;  5AHO A;  2YZ3 A;  4D1V A;  4HL2 A;  2BFZ A;  2GKL A;  3SW3 A;  4PVO A;  5AYA A;  1VGN A;  4TYF A;  5HIS A;  2NYP A;  2WYM C;  4HL1 A;  5EH9 A;  2GFJ A;  2NZF A;  1X8H A;  3A4Y A;  4RAM A;  2AIO A;  4NUR A;  4JO0 A;  3IOG A;  2WYL A;  1KR3 A;  1VJN A;  5EWA A;  5FQC A;  4RL2 A;  3IEM A;  2Q9U A;  4UWR B;  5HH4 A;  2QDT A;  2BFZ B;  2OHJ A;  3RPC A;  1JJT A;  3KL7 A;  2FU6 A;  3I14 A;  5KIK A;  5HH6 A;  5LE1 A;  4PVT A;  4CHL A;  2P1E A;  4ZEJ A;  2ZO4 A;  4UAM A;  4UA4 A;  2YNU A;  3I13 A;  4FEK A;  1WRA A;  4TYT A;  2WYM A;  2BFK A;  3SBL A;  3FAI A;  4AXH A;  5HIO A;  2NZE A;  4NQ6 A;  5LCA A;  3AJ3 A;  2E7Y A;  1A8T A;  1M2X A;  2M5C A;  5ACR A;  5K4M A;  4YSB A;  4ZO2 A;  1BMC A;  2BTN A;  1ZNB A;  4UWS B;  2XR1 A;  1DD6 A;  2FHX B;  4BZ3 A;  3X2Z A;  4B87 A;  1MQO A;  5B1U A;  1DDK A;  2QED A;  3SFP A;  4AWY B;  4F6Z A;  2FU8 A;  2GFK A;  3IEL A;  3R2U A;  2YHE A;  5ACQ A;  3AF6 A;  5LCF A;  4V0H A;  3JXP A;  1YCF A;  3T3O A;  4EXS A;  4TZ9 A;  1YCG A;  4GYQ A;  3X2Y A;  5FQB A;  5EV6 A;  1JT1 A;  3BV6 A;  2I7X A;  4EFZ A;  3ZQ4 A;  4C1E A;  1WW1 A;  5AXR A;  5LLD A;  2R2D A;  3X30 A;  2NXA A;  4PDX A;  5HIP A;  2A7M A;  4P62 A;  2CG3 A;  3P2U A;  1E5D A;  1SML A;  4J5F A;  3VQZ A;  2YCB A;  4TZF A;  2M5D A;  5AHR A;  3F9O A;  3PG4 A;  1QH3 A;  2YNT A;  2BG6 A;  2DOO A;  4XUK A;  4F6H A;  1QH5 A;  5ACT A;  3ADR A;  2CBN A;  3BK1 A;  2I7T A;  4UWO B;  2VW8 A;  5AIJ A;  4AX1 B;  3ZR9 A;  4C1D A;  5LMC A;  4D1U A;  2CFU A;  1ZTC A;  3BC2 A;  4AX0 B;  5ACS A;  4EYB A;  4U4L A;  4UWP B;  4EYF A;  3I15 A;  2CFZ A;  3RKJ A;  3BK2 A;  4DIL A;  4XWW A;  5A0T A;  3ZWF A;  4RBS A;  5LCH A;  4LE6 A;  4GCW A;  2DKF A;  1KO3 A;  2WHG A;  2CG2 A;  5LS3 A;  3DHC A;  3DH8 A;  3IEK A;  4KEP A;  3DHA A;  5ACX A;  4Z60 A;  1BC2 A;  5AXO A;  3I0V A;  4YSK A;  1A7T A;  5B15 A;  5K4N A;  2YNT B;  3IE1 A;  5EVB A;  5EW0 A;  5ACP A;  2Y8A A;  2ZZI A;  2FU9 A;  1XTO A;  1WUP A;  4Z6X A;  4RL0 A;  4C1F A;  3KNR A;  3IE2 A;  4D02 A;  3T9M A;  3DHB A;  5AEB A;  4C1G A;  5HH5 A;  2QJS A;  5FQA A;  4EY2 A;  4ZO3 A;  4AWZ A;  5A0V A;  4C09 A;  2Q0J A;  4HKY A;  3S0Z A;  1X8G A;  5AJL A;  3IOF A;  4FR7 A;  2P97 A;  1JJE A;  2H6A A;  4RM5 A;  2ZNB A;  5EV8 A;  3MD7 A;  5EHT A;  4Z5Z A;  1WUO A;  4EXY A;  4KEQ A;  4XWT A;  2AZ4 A;  2WRS A;  4D1W A;  5EVD A;  2I7V A;  4GYU A;  4D1T A;  3PY5 A;  1X8I A;  4O98 A;  5A5Z A;  5LM6 A;  4Z5Y A;  2GMN A;  2BMI A;  3KNS A;  2YNW A; 
#chains in the Genus database with same CATH homology
 1VME A;  2GCU A;  4TZE A;  4C1H A;  3ESH A;  3TP9 A;  3I11 A;  2BG8 B;  3T3N A;  3LVZ A;  4BP0 A;  1XM8 A;  4YSL A;  5DPX A;  4Z67 A;  3VPE A;  2P18 A;  4WD6 A;  4ZNB A;  1YCH A;  1K07 A;  3IE0 A;  2BG7 A;  1ZKP A;  5KIL A;  1Y44 A;  3QH8 A;  2OHH A;  4Z7R A;  5EVK A;  2BC2 A;  3SRX A;  2XF4 A;  5B3R A;  3X2X A;  2BGA A;  3PY6 A;  5HIQ A;  4DIK A;  2UYX A;  3SPU A;  2FK6 A;  2QIN A;  3Q6V A;  3H3E A;  3AF5 A;  2YNV A;  4C1C A;  1P9E A;  5IQK A;  3RKK A;  1KO2 A;  5K4K A;  3FCZ A;  5ACV A;  4H0D A;  5K0W A;  3ZNB A;  1DXK A;  3L6N A;  4UBQ A;  3G1P A;  2Q42 A;  3SD9 A;  2QDS A;  2Q0I A;  2FM6 A;  2BR6 A;  2P4Z A;  2BG2 A;  2FU7 A;  2FHX A;  1L9Y A;  4AD9 A;  4NQ4 A;  2BG8 A;  2Y87 A;  4EYL A;  4RAW A;  2ZWR A;  3WXC A;  5ACW A;  2OHI A;  4J5H A;  2Y8B A;  2HB9 A;  4TZB A;  2BFL A;  4NQ2 A;  4FSB A;  5A87 A;  5LSC A;  5ACU A;  2YNV B;  2BIB A;  3IDZ A;  4NQ5 A;  1BVT A;  1HLK A;  5AHO A;  2YZ3 A;  4D1V A;  4HL2 A;  2BFZ A;  2GKL A;  3SW3 A;  4PVO A;  5AYA A;  1VGN A;  4TYF A;  5HIS A;  2NYP A;  2WYM C;  4HL1 A;  5EH9 A;  2GFJ A;  2NZF A;  1X8H A;  3A4Y A;  4RAM A;  2AIO A;  4JO0 A;  3IOG A;  2WYL A;  1KR3 A;  1VJN A;  5EWA A;  5FQC A;  4RL2 A;  3IEM A;  2Q9U A;  4UWR B;  5HH4 A;  2QDT A;  2BFZ B;  2OHJ A;  3RPC A;  1JJT A;  3KL7 A;  2FU6 A;  3I14 A;  5KIK A;  5HH6 A;  5LE1 A;  4PVT A;  4CHL A;  2P1E A;  4ZEJ A;  2ZO4 A;  4UAM A;  4UA4 A;  2YNU A;  3I13 A;  4FEK A;  1WRA A;  4TYT A;  2WYM A;  2BFK A;  3SBL A;  3FAI A;  5HIO A;  2NZE A;  4NQ6 A;  5LCA A;  3AJ3 A;  2E7Y A;  1A8T A;  1M2X A;  2M5C A;  5ACR A;  5K4M A;  4YSB A;  4ZO2 A;  1BMC A;  2BTN A;  1ZNB A;  4UWS B;  2XR1 A;  1DD6 A;  2FHX B;  4BZ3 A;  3X2Z A;  4B87 A;  1MQO A;  5B1U A;  1DDK A;  2QED A;  3SFP A;  4AWY B;  4F6Z A;  2FU8 A;  2GFK A;  3IEL A;  3R2U A;  5ACQ A;  3AF6 A;  5LCF A;  4V0H A;  3JXP A;  1YCF A;  3T3O A;  4EXS A;  4TZ9 A;  1YCG A;  4GYQ A;  3X2Y A;  5FQB A;  5EV6 A;  1JT1 A;  3BV6 A;  2I7X A;  4EFZ A;  3ZQ4 A;  4C1E A;  1WW1 A;  5AXR A;  5LLD A;  2R2D A;  3X30 A;  2NXA A;  5HIP A;  2A7M A;  4P62 A;  3P2U A;  1E5D A;  1SML A;  4J5F A;  3VQZ A;  2YCB A;  4TZF A;  2M5D A;  5AHR A;  3F9O A;  3PG4 A;  1QH3 A;  2YNT A;  2BG6 A;  2DOO A;  4XUK A;  4F6H A;  1QH5 A;  5ACT A;  3ADR A;  2CBN A;  3BK1 A;  2I7T A;  4UWO B;  2VW8 A;  4AX1 B;  3ZR9 A;  4C1D A;  5LMC A;  4D1U A;  1ZTC A;  3BC2 A;  4AX0 B;  5ACS A;  4EYB A;  4U4L A;  4UWP B;  4EYF A;  3I15 A;  3RKJ A;  3BK2 A;  4DIL A;  4XWW A;  5A0T A;  3ZWF A;  4RBS A;  5LCH A;  4LE6 A;  4GCW A;  2DKF A;  1KO3 A;  2WHG A;  5LS3 A;  3DHC A;  3DH8 A;  3IEK A;  4KEP A;  3DHA A;  5ACX A;  4Z60 A;  1BC2 A;  5AXO A;  3I0V A;  4YSK A;  1A7T A;  5B15 A;  5K4N A;  2YNT B;  3IE1 A;  5EVB A;  5EW0 A;  5ACP A;  2Y8A A;  2ZZI A;  2FU9 A;  1XTO A;  1WUP A;  4Z6X A;  4RL0 A;  4C1F A;  3KNR A;  3IE2 A;  4D02 A;  3T9M A;  3DHB A;  5AEB A;  4C1G A;  5HH5 A;  2QJS A;  5FQA A;  4EY2 A;  4ZO3 A;  4AWZ A;  5A0V A;  4C09 A;  2Q0J A;  4HKY A;  3S0Z A;  1X8G A;  3IOF A;  4FR7 A;  2P97 A;  1JJE A;  2H6A A;  4RM5 A;  2ZNB A;  5EV8 A;  3MD7 A;  5EHT A;  4Z5Z A;  1WUO A;  4EXY A;  4KEQ A;  4XWT A;  2AZ4 A;  2WRS A;  4D1W A;  5EVD A;  2I7V A;  4GYU A;  4D1T A;  3PY5 A;  1X8I A;  4O98 A;  5A5Z A;  5LM6 A;  4Z5Y A;  2GMN A;  2BMI A;  3KNS A;  2YNW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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