5K4NA

Directed evolutionary changes in mbl super family - ndm-1 round 10 crystal-2
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
228
structure length
228
Chain Sequence
DQRFGDPVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLMVDTAGTDAQTAQILKWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPREGVVAAQHSLTFAATGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIRDSKAKSLGNLDEADTEHYAASVRAFGAAFPKASMIVMSHFAPDSRAAITHTARMADKLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Metallo-beta-lactamase type 2
publication title Enzyme evolvability is contingent on the initial sequence background
rcsb
source organism Klebsiella pneumoniae
total genus 75
structure length 228
sequence length 228
ec nomenclature
pdb deposition date 2016-05-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase; Chain A Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 5k4nA00
3L6NA 2AZ4A 5B15A 4F6ZA 5ACXA 2QINA 4D1VA 3KNRA 2GFJA 5EV8A 3IE1A 1A7TA 5B3RA 1JJEA 2ZWRA 4C1GA 2ZO4A 5LMCA 4EXYA 5HIQA 5AYAA 2FM6A 2GCUA 3DH8A 3IELA 4YSKA 4FSBA 1BMCA 5LLDA 4O98A 2DKFA 5AHOA 4F6HA 5HISA 3WXCA 2BR6A 4RL2A 5A87A 4TYFA 5ACUA 4EYFA 4RL0A 3T3OA 4AX0B 5AXRA 2P18A 2WYMA 4Z67A 4EFZA 2FU9A 2HB9A 3X30A 5KILA 3I13A 2QDSA 5LCFA 5AEBA 3DHAA 2NZFA 4FR7A 5ACRA 4UAMA 1YCFA 3ZQ4A 4KEQA 5HH4A 2QJSA 4Z5YA 3IEKA 2FHXB 4EXSA 1DXKA 3IE2A 3ESHA 5LS3A 2P1EA 5EW0A 2Y8AA 2Q0IA 4UBQA 2YCBA 3ZNBA 2Y87A 1WUOA 3SPUA 5A0VA 1DDKA 2WHGA 2QDTA 3SRXA 4HKYA 1X8IA 1QH3A 4BP0A 4NQ4A 3I14A 2NYPA 5HIPA 1YCGA 2OHJA 4UWOB 2DOOA 1YCHA 3IE0A 4UWPB 5LM6A 2BIBA 1WW1A 3AF5A 3DHBA 3F9OA 5EWAA 1ZNBA 4GCWA 3FCZA 2I7TA 4UWRB 3RPCA 1KR3A 1QH5A 4C09A 4C1DA 4C1HA 1VJNA 4NQ2A 4KEPA 4ZO3A 4DILA 5B1UA 5KIKA 2BMIA 5ACVA 2A7MA 3AF6A 1L9YA 5LCHA 5A5ZA 3MD7A 4UA4A 5HH5A 2FU7A 2GFKA 2Y8BA 2BG8A 4P62A 3BK1A 2UYXA 2BFZA 4RM5A 3PY5A 2WRSA 4CHLA 4ZNBA 2AIOA 4XWWA 4EYBA 5LE1A 2FK6A 4YSLA 3IOGA 4HL1A 3KL7A 1MQOA 3IEMA 1Y44A 5ACTA 3BK2A 3I15A 3SW3A 2P97A 4D1TA 2BFKA 3T3NA 3H3EA 4Z60A 2QEDA 3ZR9A 5EVKA 2OHIA 4GYUA 4DIKA 3RKKA 3RKJA 4C1CA 2M5DA 2YNWA 2BC2A 5IQKA 3ADRA 5EV6A 5EHTA 4FEKA 2I7XA 2I7VA 3VPEA 1KO2A 4NQ6A 4D1WA 2BG7A 1A8TA 1VMEA 4TZ9A 4RAWA 5EVDA 3QH8A 1XTOA 3I0VA 2E7YA 3R2UA 4AD9A 4HL2A 3PG4A 3X2ZA 4Z7RA 4D1UA 4B87A 4ZEJA 2YNVA 1K07A 3JXPA 5K4NA 4TYTA 4RBSA 2BG6A 3PY6A 4AX1B 5DPXA 1KO3A 2YNTB 2R2DA 2BTNA 4UWSB 3BV6A 1DD6A 3DHCA 2VW8A 2YNTA 1XM8A 1JJTA 2YNUA 3S0ZA 3LVZA 3IOFA 4XWTA 5AHRA 4XUKA 5EVBA 3Q6VA 1VGNA 5HH6A 3X2XA 5LSCA 5K4MA 5FQCA 4C1EA 4EY2A 4V0HA 2BG8B 4PVOA 3P2UA 3X2YA 2WYLA 5ACQA 2BFZB 3I11A 1BVTA 5ACWA 3G1PA 5LCAA 4WD6A 4AWZA 2ZNBA 3T9MA 4J5FA 4ZO2A 4JO0A 2M5CA 5HIOA 2GKLA 1BC2A 2Q9UA 2Q0JA 4YSBA 4C1FA 2NZEA 5K0WA 4NQ5A 2YZ3A 1ZKPA 2XR1A 3KNSA 4Z5ZA 2OHHA 4PVTA 2FU6A 5A0TA 4TZEA 4J5HA 2BGAA 5AXOA 4GYQA 2BFLA 4TZBA 2BG2A 1WUPA 5K4KA 3A4YA 4D02A 5FQAA 2FU8A 1ZTCA 3SFPA 4AWYB 4RAMA 2P4ZA 2YNVB 3BC2A 4H0DA 4EYLA 5ACPA 3VQZA 4U4LA 1X8HA 1E5DA 2NXAA 3ZWFA 1X8GA 4TZFA 4BZ3A 5ACSA 1M2XA 2FHXA 3AJ3A 3TP9A 5FQBA 3SBLA 2Q42A 3SD9A 1JT1A 2H6AA 4LE6A 3FAIA 1SMLA 1WRAA 5EH9A 3IDZA 1HLKA 2XF4A 2GMNA 4Z6XA 2ZZIA 2WYMC 1P9EA 2CBNA
chains in the Genus database with same CATH superfamily
3L6NA 2AZ4A 5B15A 4F6ZA 5ACXA 2QINA 4D1VA 3KNRA 2GFJA 5EV8A 3IE1A 1A7TA 5B3RA 1JJEA 2ZWRA 4C1GA 2ZO4A 5LMCA 4EXYA 5HIQA 5AYAA 2FM6A 2GCUA 3DH8A 3IELA 4YSKA 4FSBA 1BMCA 5LLDA 4O98A 2DKFA 5AHOA 4F6HA 5HISA 3WXCA 2BR6A 4RL2A 5A87A 4TYFA 5ACUA 4EYFA 4RL0A 3T3OA 4AX0B 5AXRA 2P18A 2WYMA 4Z67A 5AJLA 4EFZA 2FU9A 2HB9A 3X30A 5KILA 3I13A 2QDSA 5LCFA 5AEBA 3DHAA 2NZFA 4FR7A 5ACRA 4UAMA 1YCFA 3ZQ4A 4KEQA 5HH4A 2QJSA 4Z5YA 3IEKA 2FHXB 4EXSA 1DXKA 3IE2A 3ESHA 5LS3A 2P1EA 5EW0A 2Y8AA 2Q0IA 4UBQA 2CG2A 2YCBA 3ZNBA 2Y87A 1WUOA 3SPUA 5A0VA 1DDKA 2WHGA 2QDTA 3SRXA 4HKYA 1X8IA 1QH3A 4BP0A 4NQ4A 3I14A 2NYPA 5HIPA 1YCGA 2OHJA 4UWOB 2DOOA 1YCHA 3IE0A 4UWPB 5LM6A 2BIBA 1WW1A 3AF5A 3DHBA 3F9OA 5EWAA 1ZNBA 4GCWA 3FCZA 2I7TA 4UWRB 3RPCA 2YHEA 1KR3A 1QH5A 4C09A 4C1DA 4C1HA 1VJNA 4NQ2A 4KEPA 4ZO3A 4DILA 5B1UA 5KIKA 2BMIA 5ACVA 2A7MA 3AF6A 5A23A 1L9YA 5LCHA 5A5ZA 3MD7A 4UA4A 5HH5A 2FU7A 2GFKA 2Y8BA 2BG8A 4P62A 3BK1A 2UYXA 2BFZA 4RM5A 3PY5A 2WRSA 4CHLA 4ZNBA 2AIOA 4XWWA 4EYBA 5LE1A 2FK6A 4YSLA 3IOGA 4HL1A 3KL7A 1MQOA 3IEMA 1Y44A 5ACTA 3BK2A 3I15A 3SW3A 2P97A 4D1TA 2BFKA 3T3NA 3H3EA 4Z60A 2QEDA 3ZR9A 4NURA 5EVKA 2CFZA 2OHIA 4GYUA 4DIKA 3RKKA 4C1CA 3RKJA 2M5DA 2YNWA 2BC2A 5IQKA 2CFUA 3ADRA 5EV6A 5EHTA 4FEKA 2I7XA 2I7VA 3VPEA 1KO2A 4NQ6A 4D1WA 2BG7A 1A8TA 1VMEA 4TZ9A 4RAWA 5EVDA 3QH8A 1XTOA 3I0VA 2E7YA 3R2UA 4AD9A 4HL2A 3PG4A 3X2ZA 4Z7RA 4D1UA 4B87A 4ZEJA 2YNVA 1K07A 3JXPA 5K4NA 4TYTA 4RBSA 2BG6A 3PY6A 4AX1B 5DPXA 1KO3A 2YNTB 2R2DA 2BTNA 4UWSB 3BV6A 1DD6A 3DHCA 2VW8A 4PDXA 2YNTA 1XM8A 1JJTA 2YNUA 3S0ZA 3LVZA 3IOFA 4XWTA 5AHRA 4XUKA 5EVBA 3Q6VA 1VGNA 5HH6A 3X2XA 5LSCA 5K4MA 5FQCA 4C1EA 4EY2A 4V0HA 2BG8B 4PVOA 3P2UA 3X2YA 2WYLA 5ACQA 2BFZB 3I11A 1BVTA 5ACWA 3G1PA 5LCAA 4WD6A 4AWZA 2ZNBA 3T9MA 4J5FA 4ZO2A 4JO0A 2M5CA 5HIOA 2GKLA 1BC2A 2Q9UA 2Q0JA 4YSBA 4C1FA 2NZEA 5K0WA 4NQ5A 2YZ3A 1ZKPA 2XR1A 3KNSA 4Z5ZA 2OHHA 4AXHA 4PVTA 2FU6A 5A0TA 4TZEA 4J5HA 2BGAA 2CG3A 5AXOA 5AIJA 4GYQA 2BFLA 4TZBA 2BG2A 1WUPA 5K4KA 3A4YA 4D02A 5FQAA 2FU8A 1ZTCA 3SFPA 4AWYB 4RAMA 2P4ZA 2YNVB 3BC2A 4H0DA 4EYLA 5ACPA 3VQZA 4U4LA 1X8HA 1E5DA 2NXAA 3ZWFA 1X8GA 4TZFA 4BZ3A 4AV7A 5ACSA 1M2XA 2FHXA 3AJ3A 3TP9A 5FQBA 3SBLA 2Q42A 3SD9A 1JT1A 2H6AA 4LE6A 3FAIA 1SMLA 1WRAA 5EH9A 3IDZA 1HLKA 2XF4A 2GMNA 4Z6XA 2ZZIA 2WYMC 1P9EA 2CBNA
chains in the Genus database with same CATH topology
3L6NA 2AZ4A 5B15A 4F6ZA 5ACXA 2QINA 4D1VA 3KNRA 2GFJA 5EV8A 3IE1A 1A7TA 5B3RA 1JJEA 2ZWRA 4C1GA 2ZO4A 5LMCA 4EXYA 5HIQA 5AYAA 2FM6A 2GCUA 3DH8A 3IELA 4YSKA 4FSBA 1BMCA 5LLDA 4O98A 2DKFA 5AHOA 4F6HA 5HISA 3WXCA 2BR6A 4RL2A 5A87A 4TYFA 5ACUA 4EYFA 4RL0A 3T3OA 4AX0B 5AXRA 2P18A 2WYMA 4Z67A 4EFZA 2FU9A 2HB9A 3X30A 5KILA 3I13A 2QDSA 5LCFA 5AEBA 3DHAA 2NZFA 4FR7A 5ACRA 4UAMA 1YCFA 3ZQ4A 4KEQA 5HH4A 2QJSA 4Z5YA 3IEKA 2FHXB 4EXSA 1DXKA 3IE2A 3ESHA 5LS3A 2P1EA 5EW0A 2Y8AA 2Q0IA 4UBQA 2YCBA 3ZNBA 2Y87A 1WUOA 3SPUA 5A0VA 1DDKA 2WHGA 2QDTA 3SRXA 4HKYA 1X8IA 1QH3A 4BP0A 4NQ4A 3I14A 2NYPA 5HIPA 1YCGA 2OHJA 4UWOB 2DOOA 1YCHA 3IE0A 4UWPB 5LM6A 2BIBA 1WW1A 3AF5A 3DHBA 3F9OA 5EWAA 1ZNBA 4GCWA 3FCZA 2I7TA 4UWRB 3RPCA 1KR3A 1QH5A 4C09A 4C1DA 4C1HA 1VJNA 4NQ2A 4KEPA 4ZO3A 4DILA 5B1UA 5KIKA 2BMIA 5ACVA 2A7MA 3AF6A 1L9YA 5LCHA 5A5ZA 3MD7A 4UA4A 5HH5A 2FU7A 2GFKA 2Y8BA 2BG8A 4P62A 3BK1A 2UYXA 2BFZA 4RM5A 3PY5A 2WRSA 4CHLA 4ZNBA 2AIOA 4XWWA 4EYBA 5LE1A 2FK6A 4YSLA 3IOGA 4HL1A 3KL7A 1MQOA 3IEMA 1Y44A 5ACTA 3BK2A 3I15A 3SW3A 2P97A 4D1TA 2BFKA 3T3NA 3H3EA 4Z60A 2QEDA 3ZR9A 5EVKA 2OHIA 4GYUA 4DIKA 3RKKA 3RKJA 4C1CA 2M5DA 2YNWA 2BC2A 5IQKA 3ADRA 5EV6A 5EHTA 4FEKA 2I7XA 2I7VA 3VPEA 1KO2A 4NQ6A 4D1WA 2BG7A 1A8TA 1VMEA 4TZ9A 4RAWA 5EVDA 3QH8A 1XTOA 3I0VA 2E7YA 3R2UA 4AD9A 4HL2A 3PG4A 3X2ZA 4Z7RA 4D1UA 4B87A 4ZEJA 2YNVA 1K07A 3JXPA 5K4NA 4TYTA 4RBSA 2BG6A 3PY6A 4AX1B 5DPXA 1KO3A 2YNTB 2R2DA 2BTNA 4UWSB 3BV6A 1DD6A 3DHCA 2VW8A 2YNTA 1XM8A 1JJTA 2YNUA 3S0ZA 3LVZA 3IOFA 4XWTA 5AHRA 4XUKA 5EVBA 3Q6VA 1VGNA 5HH6A 3X2XA 5LSCA 5K4MA 5FQCA 4C1EA 4EY2A 4V0HA 2BG8B 4PVOA 3P2UA 3X2YA 2WYLA 5ACQA 2BFZB 3I11A 1BVTA 5ACWA 3G1PA 5LCAA 4WD6A 4AWZA 2ZNBA 3T9MA 4J5FA 4ZO2A 4JO0A 2M5CA 5HIOA 2GKLA 1BC2A 2Q9UA 2Q0JA 4YSBA 4C1FA 2NZEA 5K0WA 4NQ5A 2YZ3A 1ZKPA 2XR1A 3KNSA 4Z5ZA 2OHHA 4PVTA 2FU6A 5A0TA 4TZEA 4J5HA 2BGAA 5AXOA 4GYQA 2BFLA 4TZBA 2BG2A 1WUPA 5K4KA 3A4YA 4D02A 5FQAA 2FU8A 1ZTCA 3SFPA 4AWYB 4RAMA 2P4ZA 2YNVB 3BC2A 4H0DA 4EYLA 5ACPA 3VQZA 4U4LA 1X8HA 1E5DA 2NXAA 3ZWFA 1X8GA 4TZFA 4BZ3A 5ACSA 1M2XA 2FHXA 3AJ3A 3TP9A 5FQBA 3SBLA 2Q42A 3SD9A 1JT1A 2H6AA 4LE6A 3FAIA 1SMLA 1WRAA 5EH9A 3IDZA 1HLKA 2XF4A 2GMNA 4Z6XA 2ZZIA 2WYMC 1P9EA 2CBNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3L6N A;  2AZ4 A;  5B15 A;  4F6Z A;  5ACX A;  2QIN A;  4D1V A;  3KNR A;  2GFJ A;  5EV8 A;  3IE1 A;  1A7T A;  5B3R A;  1JJE A;  2ZWR A;  4C1G A;  2ZO4 A;  5LMC A;  4EXY A;  5HIQ A;  5AYA A;  2FM6 A;  2GCU A;  3DH8 A;  3IEL A;  4YSK A;  4FSB A;  1BMC A;  5LLD A;  4O98 A;  2DKF A;  5AHO A;  4F6H A;  5HIS A;  3WXC A;  2BR6 A;  4RL2 A;  5A87 A;  4TYF A;  5ACU A;  4EYF A;  4RL0 A;  3T3O A;  4AX0 B;  5AXR A;  2P18 A;  2WYM A;  4Z67 A;  4EFZ A;  2FU9 A;  2HB9 A;  3X30 A;  5KIL A;  3I13 A;  2QDS A;  5LCF A;  5AEB A;  3DHA A;  2NZF A;  4FR7 A;  5ACR A;  4UAM A;  1YCF A;  3ZQ4 A;  4KEQ A;  5HH4 A;  2QJS A;  4Z5Y A;  3IEK A;  2FHX B;  4EXS A;  1DXK A;  3IE2 A;  3ESH A;  5LS3 A;  2P1E A;  5EW0 A;  2Y8A A;  2Q0I A;  4UBQ A;  2YCB A;  3ZNB A;  2Y87 A;  1WUO A;  3SPU A;  5A0V A;  1DDK A;  2WHG A;  2QDT A;  3SRX A;  4HKY A;  1X8I A;  1QH3 A;  4BP0 A;  4NQ4 A;  3I14 A;  2NYP A;  5HIP A;  1YCG A;  2OHJ A;  4UWO B;  2DOO A;  1YCH A;  3IE0 A;  4UWP B;  5LM6 A;  2BIB A;  1WW1 A;  3AF5 A;  3DHB A;  3F9O A;  5EWA A;  1ZNB A;  4GCW A;  3FCZ A;  2I7T A;  4UWR B;  3RPC A;  1KR3 A;  1QH5 A;  4C09 A;  4C1D A;  4C1H A;  1VJN A;  4NQ2 A;  4KEP A;  4ZO3 A;  4DIL A;  5B1U A;  5KIK A;  2BMI A;  5ACV A;  2A7M A;  3AF6 A;  1L9Y A;  5LCH A;  5A5Z A;  3MD7 A;  4UA4 A;  5HH5 A;  2FU7 A;  2GFK A;  2Y8B A;  2BG8 A;  4P62 A;  3BK1 A;  2UYX A;  2BFZ A;  4RM5 A;  3PY5 A;  2WRS A;  4CHL A;  4ZNB A;  2AIO A;  4XWW A;  4EYB A;  5LE1 A;  2FK6 A;  4YSL A;  3IOG A;  4HL1 A;  3KL7 A;  1MQO A;  3IEM A;  1Y44 A;  5ACT A;  3BK2 A;  3I15 A;  3SW3 A;  2P97 A;  4D1T A;  2BFK A;  3T3N A;  3H3E A;  4Z60 A;  2QED A;  3ZR9 A;  5EVK A;  2OHI A;  4GYU A;  4DIK A;  3RKK A;  3RKJ A;  4C1C A;  2M5D A;  2YNW A;  2BC2 A;  5IQK A;  3ADR A;  5EV6 A;  5EHT A;  4FEK A;  2I7X A;  2I7V A;  3VPE A;  1KO2 A;  4NQ6 A;  4D1W A;  2BG7 A;  1A8T A;  1VME A;  4TZ9 A;  4RAW A;  5EVD A;  3QH8 A;  1XTO A;  3I0V A;  2E7Y A;  3R2U A;  4AD9 A;  4HL2 A;  3PG4 A;  3X2Z A;  4Z7R A;  4D1U A;  4B87 A;  4ZEJ A;  2YNV A;  1K07 A;  3JXP A;  5K4N A;  4TYT A;  4RBS A;  2BG6 A;  3PY6 A;  4AX1 B;  5DPX A;  1KO3 A;  2YNT B;  2R2D A;  2BTN A;  4UWS B;  3BV6 A;  1DD6 A;  3DHC A;  2VW8 A;  2YNT A;  1XM8 A;  1JJT A;  2YNU A;  3S0Z A;  3LVZ A;  3IOF A;  4XWT A;  5AHR A;  4XUK A;  5EVB A;  3Q6V A;  1VGN A;  5HH6 A;  3X2X A;  5LSC A;  5K4M A;  5FQC A;  4C1E A;  4EY2 A;  4V0H A;  2BG8 B;  4PVO A;  3P2U A;  3X2Y A;  2WYL A;  5ACQ A;  2BFZ B;  3I11 A;  1BVT A;  5ACW A;  3G1P A;  5LCA A;  4WD6 A;  4AWZ A;  2ZNB A;  3T9M A;  4J5F A;  4ZO2 A;  4JO0 A;  2M5C A;  5HIO A;  2GKL A;  1BC2 A;  2Q9U A;  2Q0J A;  4YSB A;  4C1F A;  2NZE A;  5K0W A;  4NQ5 A;  2YZ3 A;  1ZKP A;  2XR1 A;  3KNS A;  4Z5Z A;  2OHH A;  4PVT A;  2FU6 A;  5A0T A;  4TZE A;  4J5H A;  2BGA A;  5AXO A;  4GYQ A;  2BFL A;  4TZB A;  2BG2 A;  1WUP A;  5K4K A;  3A4Y A;  4D02 A;  5FQA A;  2FU8 A;  1ZTC A;  3SFP A;  4AWY B;  4RAM A;  2P4Z A;  2YNV B;  3BC2 A;  4H0D A;  4EYL A;  5ACP A;  3VQZ A;  4U4L A;  1X8H A;  1E5D A;  2NXA A;  3ZWF A;  1X8G A;  4TZF A;  4BZ3 A;  5ACS A;  1M2X A;  2FHX A;  3AJ3 A;  3TP9 A;  5FQB A;  3SBL A;  2Q42 A;  3SD9 A;  1JT1 A;  2H6A A;  4LE6 A;  3FAI A;  1SML A;  1WRA A;  5EH9 A;  3IDZ A;  1HLK A;  2XF4 A;  2GMN A;  4Z6X A;  2ZZI A;  2WYM C;  1P9E A;  2CBN A; 
#chains in the Genus database with same CATH topology
 3L6N A;  2AZ4 A;  5B15 A;  4F6Z A;  5ACX A;  2QIN A;  4D1V A;  3KNR A;  2GFJ A;  5EV8 A;  3IE1 A;  1A7T A;  5B3R A;  1JJE A;  2ZWR A;  4C1G A;  2ZO4 A;  5LMC A;  4EXY A;  5HIQ A;  5AYA A;  2FM6 A;  2GCU A;  3DH8 A;  3IEL A;  4YSK A;  4FSB A;  1BMC A;  5LLD A;  4O98 A;  2DKF A;  5AHO A;  4F6H A;  5HIS A;  3WXC A;  2BR6 A;  4RL2 A;  5A87 A;  4TYF A;  5ACU A;  4EYF A;  4RL0 A;  3T3O A;  4AX0 B;  5AXR A;  2P18 A;  2WYM A;  4Z67 A;  5AJL A;  4EFZ A;  2FU9 A;  2HB9 A;  3X30 A;  5KIL A;  3I13 A;  2QDS A;  5LCF A;  5AEB A;  3DHA A;  2NZF A;  4FR7 A;  5ACR A;  4UAM A;  1YCF A;  3ZQ4 A;  4KEQ A;  5HH4 A;  2QJS A;  4Z5Y A;  3IEK A;  2FHX B;  4EXS A;  1DXK A;  3IE2 A;  3ESH A;  5LS3 A;  2P1E A;  5EW0 A;  2Y8A A;  2Q0I A;  4UBQ A;  2CG2 A;  2YCB A;  3ZNB A;  2Y87 A;  1WUO A;  3SPU A;  5A0V A;  1DDK A;  2WHG A;  2QDT A;  3SRX A;  4HKY A;  1X8I A;  1QH3 A;  4BP0 A;  4NQ4 A;  3I14 A;  2NYP A;  5HIP A;  1YCG A;  2OHJ A;  4UWO B;  2DOO A;  1YCH A;  3IE0 A;  4UWP B;  5LM6 A;  2BIB A;  1WW1 A;  3AF5 A;  3DHB A;  3F9O A;  5EWA A;  1ZNB A;  4GCW A;  3FCZ A;  2I7T A;  4UWR B;  3RPC A;  2YHE A;  1KR3 A;  1QH5 A;  4C09 A;  4C1D A;  4C1H A;  1VJN A;  4NQ2 A;  4KEP A;  4ZO3 A;  4DIL A;  5B1U A;  5KIK A;  2BMI A;  5ACV A;  2A7M A;  3AF6 A;  5A23 A;  1L9Y A;  5LCH A;  5A5Z A;  3MD7 A;  4UA4 A;  5HH5 A;  2FU7 A;  2GFK A;  2Y8B A;  2BG8 A;  4P62 A;  3BK1 A;  2UYX A;  2BFZ A;  4RM5 A;  3PY5 A;  2WRS A;  4CHL A;  4ZNB A;  2AIO A;  4XWW A;  4EYB A;  5LE1 A;  2FK6 A;  4YSL A;  3IOG A;  4HL1 A;  3KL7 A;  1MQO A;  3IEM A;  1Y44 A;  5ACT A;  3BK2 A;  3I15 A;  3SW3 A;  2P97 A;  4D1T A;  2BFK A;  3T3N A;  3H3E A;  4Z60 A;  2QED A;  3ZR9 A;  4NUR A;  5EVK A;  2CFZ A;  2OHI A;  4GYU A;  4DIK A;  3RKK A;  4C1C A;  3RKJ A;  2M5D A;  2YNW A;  2BC2 A;  5IQK A;  2CFU A;  3ADR A;  5EV6 A;  5EHT A;  4FEK A;  2I7X A;  2I7V A;  3VPE A;  1KO2 A;  4NQ6 A;  4D1W A;  2BG7 A;  1A8T A;  1VME A;  4TZ9 A;  4RAW A;  5EVD A;  3QH8 A;  1XTO A;  3I0V A;  2E7Y A;  3R2U A;  4AD9 A;  4HL2 A;  3PG4 A;  3X2Z A;  4Z7R A;  4D1U A;  4B87 A;  4ZEJ A;  2YNV A;  1K07 A;  3JXP A;  5K4N A;  4TYT A;  4RBS A;  2BG6 A;  3PY6 A;  4AX1 B;  5DPX A;  1KO3 A;  2YNT B;  2R2D A;  2BTN A;  4UWS B;  3BV6 A;  1DD6 A;  3DHC A;  2VW8 A;  4PDX A;  2YNT A;  1XM8 A;  1JJT A;  2YNU A;  3S0Z A;  3LVZ A;  3IOF A;  4XWT A;  5AHR A;  4XUK A;  5EVB A;  3Q6V A;  1VGN A;  5HH6 A;  3X2X A;  5LSC A;  5K4M A;  5FQC A;  4C1E A;  4EY2 A;  4V0H A;  2BG8 B;  4PVO A;  3P2U A;  3X2Y A;  2WYL A;  5ACQ A;  2BFZ B;  3I11 A;  1BVT A;  5ACW A;  3G1P A;  5LCA A;  4WD6 A;  4AWZ A;  2ZNB A;  3T9M A;  4J5F A;  4ZO2 A;  4JO0 A;  2M5C A;  5HIO A;  2GKL A;  1BC2 A;  2Q9U A;  2Q0J A;  4YSB A;  4C1F A;  2NZE A;  5K0W A;  4NQ5 A;  2YZ3 A;  1ZKP A;  2XR1 A;  3KNS A;  4Z5Z A;  2OHH A;  4AXH A;  4PVT A;  2FU6 A;  5A0T A;  4TZE A;  4J5H A;  2BGA A;  2CG3 A;  5AXO A;  5AIJ A;  4GYQ A;  2BFL A;  4TZB A;  2BG2 A;  1WUP A;  5K4K A;  3A4Y A;  4D02 A;  5FQA A;  2FU8 A;  1ZTC A;  3SFP A;  4AWY B;  4RAM A;  2P4Z A;  2YNV B;  3BC2 A;  4H0D A;  4EYL A;  5ACP A;  3VQZ A;  4U4L A;  1X8H A;  1E5D A;  2NXA A;  3ZWF A;  1X8G A;  4TZF A;  4BZ3 A;  4AV7 A;  5ACS A;  1M2X A;  2FHX A;  3AJ3 A;  3TP9 A;  5FQB A;  3SBL A;  2Q42 A;  3SD9 A;  1JT1 A;  2H6A A;  4LE6 A;  3FAI A;  1SML A;  1WRA A;  5EH9 A;  3IDZ A;  1HLK A;  2XF4 A;  2GMN A;  4Z6X A;  2ZZI A;  2WYM C;  1P9E A;  2CBN A; 
#chains in the Genus database with same CATH homology
 3L6N A;  2AZ4 A;  5B15 A;  4F6Z A;  5ACX A;  2QIN A;  4D1V A;  3KNR A;  2GFJ A;  5EV8 A;  3IE1 A;  1A7T A;  5B3R A;  1JJE A;  2ZWR A;  4C1G A;  2ZO4 A;  5LMC A;  4EXY A;  5HIQ A;  5AYA A;  2FM6 A;  2GCU A;  3DH8 A;  3IEL A;  4YSK A;  4FSB A;  1BMC A;  5LLD A;  4O98 A;  2DKF A;  5AHO A;  4F6H A;  5HIS A;  3WXC A;  2BR6 A;  4RL2 A;  5A87 A;  4TYF A;  5ACU A;  4EYF A;  4RL0 A;  3T3O A;  4AX0 B;  5AXR A;  2P18 A;  2WYM A;  4Z67 A;  4EFZ A;  2FU9 A;  2HB9 A;  3X30 A;  5KIL A;  3I13 A;  2QDS A;  5LCF A;  5AEB A;  3DHA A;  2NZF A;  4FR7 A;  5ACR A;  4UAM A;  1YCF A;  3ZQ4 A;  4KEQ A;  5HH4 A;  2QJS A;  4Z5Y A;  3IEK A;  2FHX B;  4EXS A;  1DXK A;  3IE2 A;  3ESH A;  5LS3 A;  2P1E A;  5EW0 A;  2Y8A A;  2Q0I A;  4UBQ A;  2YCB A;  3ZNB A;  2Y87 A;  1WUO A;  3SPU A;  5A0V A;  1DDK A;  2WHG A;  2QDT A;  3SRX A;  4HKY A;  1X8I A;  1QH3 A;  4BP0 A;  4NQ4 A;  3I14 A;  2NYP A;  5HIP A;  1YCG A;  2OHJ A;  4UWO B;  2DOO A;  1YCH A;  3IE0 A;  4UWP B;  5LM6 A;  2BIB A;  1WW1 A;  3AF5 A;  3DHB A;  3F9O A;  5EWA A;  1ZNB A;  4GCW A;  3FCZ A;  2I7T A;  4UWR B;  3RPC A;  1KR3 A;  1QH5 A;  4C09 A;  4C1D A;  4C1H A;  1VJN A;  4NQ2 A;  4KEP A;  4ZO3 A;  4DIL A;  5B1U A;  5KIK A;  2BMI A;  5ACV A;  2A7M A;  3AF6 A;  1L9Y A;  5LCH A;  5A5Z A;  3MD7 A;  4UA4 A;  5HH5 A;  2FU7 A;  2GFK A;  2Y8B A;  2BG8 A;  4P62 A;  3BK1 A;  2UYX A;  2BFZ A;  4RM5 A;  3PY5 A;  2WRS A;  4CHL A;  4ZNB A;  2AIO A;  4XWW A;  4EYB A;  5LE1 A;  2FK6 A;  4YSL A;  3IOG A;  4HL1 A;  3KL7 A;  1MQO A;  3IEM A;  1Y44 A;  5ACT A;  3BK2 A;  3I15 A;  3SW3 A;  2P97 A;  4D1T A;  2BFK A;  3T3N A;  3H3E A;  4Z60 A;  2QED A;  3ZR9 A;  5EVK A;  2OHI A;  4GYU A;  4DIK A;  3RKK A;  3RKJ A;  4C1C A;  2M5D A;  2YNW A;  2BC2 A;  5IQK A;  3ADR A;  5EV6 A;  5EHT A;  4FEK A;  2I7X A;  2I7V A;  3VPE A;  1KO2 A;  4NQ6 A;  4D1W A;  2BG7 A;  1A8T A;  1VME A;  4TZ9 A;  4RAW A;  5EVD A;  3QH8 A;  1XTO A;  3I0V A;  2E7Y A;  3R2U A;  4AD9 A;  4HL2 A;  3PG4 A;  3X2Z A;  4Z7R A;  4D1U A;  4B87 A;  4ZEJ A;  2YNV A;  1K07 A;  3JXP A;  5K4N A;  4TYT A;  4RBS A;  2BG6 A;  3PY6 A;  4AX1 B;  5DPX A;  1KO3 A;  2YNT B;  2R2D A;  2BTN A;  4UWS B;  3BV6 A;  1DD6 A;  3DHC A;  2VW8 A;  2YNT A;  1XM8 A;  1JJT A;  2YNU A;  3S0Z A;  3LVZ A;  3IOF A;  4XWT A;  5AHR A;  4XUK A;  5EVB A;  3Q6V A;  1VGN A;  5HH6 A;  3X2X A;  5LSC A;  5K4M A;  5FQC A;  4C1E A;  4EY2 A;  4V0H A;  2BG8 B;  4PVO A;  3P2U A;  3X2Y A;  2WYL A;  5ACQ A;  2BFZ B;  3I11 A;  1BVT A;  5ACW A;  3G1P A;  5LCA A;  4WD6 A;  4AWZ A;  2ZNB A;  3T9M A;  4J5F A;  4ZO2 A;  4JO0 A;  2M5C A;  5HIO A;  2GKL A;  1BC2 A;  2Q9U A;  2Q0J A;  4YSB A;  4C1F A;  2NZE A;  5K0W A;  4NQ5 A;  2YZ3 A;  1ZKP A;  2XR1 A;  3KNS A;  4Z5Z A;  2OHH A;  4PVT A;  2FU6 A;  5A0T A;  4TZE A;  4J5H A;  2BGA A;  5AXO A;  4GYQ A;  2BFL A;  4TZB A;  2BG2 A;  1WUP A;  5K4K A;  3A4Y A;  4D02 A;  5FQA A;  2FU8 A;  1ZTC A;  3SFP A;  4AWY B;  4RAM A;  2P4Z A;  2YNV B;  3BC2 A;  4H0D A;  4EYL A;  5ACP A;  3VQZ A;  4U4L A;  1X8H A;  1E5D A;  2NXA A;  3ZWF A;  1X8G A;  4TZF A;  4BZ3 A;  5ACS A;  1M2X A;  2FHX A;  3AJ3 A;  3TP9 A;  5FQB A;  3SBL A;  2Q42 A;  3SD9 A;  1JT1 A;  2H6A A;  4LE6 A;  3FAI A;  1SML A;  1WRA A;  5EH9 A;  3IDZ A;  1HLK A;  2XF4 A;  2GMN A;  4Z6X A;  2ZZI A;  2WYM C;  1P9E A;  2CBN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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