5K4NA

Directed evolutionary changes in mbl super family - ndm-1 round 10 crystal-2
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
228
structure length
228
Chain Sequence
DQRFGDPVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLMVDTAGTDAQTAQILKWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPREGVVAAQHSLTFAATGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIRDSKAKSLGNLDEADTEHYAASVRAFGAAFPKASMIVMSHFAPDSRAAITHTARMADKLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Enzyme evolvability is contingent on the initial sequence background
rcsb
source organism Klebsiella pneumoniae
molecule tags Hydrolase
molecule keywords Metallo-beta-lactamase type 2
total genus 75
structure length 228
sequence length 228
ec nomenclature
pdb deposition date 2016-05-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase; Chain A Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 5k4nA00
4UWSB 2OHIA 4UWPB 3I14A 4BP0A 2WYMC 2XF4A 1JJTA 2FM6A 4UBQA 2YNWA 4NQ2A 1BVTA 4DIKA 3I15A 2FHXA 4HL2A 1WW1A 4YSKA 3QH8A 4AWYB 2I7TA 5EHTA 2P18A 5HH5A 4AWZA 1XM8A 2AZ4A 3RKJA 4V0HA 5K4KA 1YCGA 1L9YA 4F6ZA 2CBNA 4F6HA 5B3RA 5K0WA 1KO3A 2FU8A 4Z60A 5EW0A 4D02A 2DOOA 1VMEA 4PVTA 3S0ZA 3AF6A 5B1UA 2YCBA 3RKKA 2Q9UA 4GYQA 4D1UA 4C1HA 4UAMA 3I0VA 4C1FA 2A7MA 4C1EA 3G1PA 2Y8AA 3IDZA 5HH4A 2BC2A 1X8IA 2BG6A 5AHOA 2ZWRA 4TZBA 4EYFA 2NZEA 1JJEA 5HIOA 2QEDA 5EVDA 4GYUA 3ZWFA 5FQAA 2WHGA 5LMCA 4NQ5A 3PY6A 1KR3A 2BR6A 2BTNA 4FR7A 2GFJA 4EYBA 5HH6A 5HIPA 4Z7RA 3BV6A 1X8HA 5ACQA 4RAMA 3ZQ4A 2YNVA 5ACVA 2ZNBA 4D1WA 2ZZIA 2DKFA 4J5FA 3FAIA 4O98A 3SD9A 1XTOA 2WYMA 4CHLA 1Y44A 4EXYA 2FU9A 3DHBA 5LCAA 3LVZA 2FU7A 3X2YA 2I7VA 1BC2A 1VJNA 3DH8A 4H0DA 4UA4A 5AXOA 3IE2A 2OHJA 4UWOB 4J5HA 2Q0JA 3X2ZA 5LM6A 5KILA 3I11A 3T3NA 4Z6XA 2BMIA 3SPUA 1WRAA 2Q0IA 3DHCA 1WUOA 4UWRB 3BK1A 3KL7A 2BG2A 3JXPA 4HL1A 3DHAA 5EH9A 2BFZA 4U4LA 5AXRA 2QDSA 4TZ9A 4AD9A 4Z5ZA 2BG7A 1DD6A 3SFPA 2Y8BA 5ACSA 4TYFA 5ACRA 5KIKA 4C1GA 5HISA 4ZO3A 4FSBA 3I13A 4Z5YA 1YCHA 3ADRA 3BC2A 1VGNA 1MQOA 4DILA 2M5CA 2YZ3A 3SW3A 4AX1B 2FHXB 3IOFA 5LLDA 2NYPA 1QH5A 3PG4A 4YSBA 3IOGA 1QH3A 2HB9A 4XWWA 4LE6A 5AYAA 2GCUA 3IEKA 3ZR9A 1ZTCA 5LS3A 1X8GA 4ZEJA 5EVKA 3KNRA 3IE0A 4YSLA 3SBLA 1A7TA 5EV8A 3AF5A 2P97A 4Z67A 3R2UA 4NQ4A 5A0TA 4KEPA 3SRXA 3T9MA 5LCFA 1ZNBA 3KNSA 2BFZB 1SMLA 2XR1A 2QINA 2WRSA 4TZFA 3IEMA 2P1EA 4XWTA 4NQ6A 4TYTA 5FQBA 5FQCA 1A8TA 5HIQA 2GMNA 2YNTA 4PVOA 3VPEA 2M5DA 2NXAA 5A87A 2WYLA 4ZO2A 2I7XA 2VW8A 3P2UA 2FK6A 5A5ZA 3T3OA 4KEQA 3Q6VA 3X2XA 4EFZA 5LE1A 4FEKA 1DDKA 5DPXA 3RPCA 1WUPA 3ESHA 4RL2A 5B15A 4RBSA 4JO0A 5K4NA 3ZNBA 1HLKA 3PY5A 4D1TA 3H3EA 3AJ3A 5LSCA 4WD6A 2BGAA 3VQZA 2E7YA 2YNTB 2R2DA 3BK2A 1P9EA 2BFKA 2GFKA 4C1CA 2AIOA 5ACUA 1JT1A 2Q42A 4EXSA 5EVBA 2YNUA 1BMCA 3L6NA 5ACXA 4TZEA 4RAWA 1E5DA 2BG8A 5K4MA 2FU6A 5ACPA 3X30A 2NZFA 2Y87A 4BZ3A 2H6AA 3IE1A 3TP9A 2OHHA 1K07A 4RM5A 1DXKA 4C09A 5IQKA 4EYLA 2QDTA 1M2XA 5ACTA 1YCFA 2ZO4A 5EV6A 2QJSA 5AEBA 3A4YA 4B87A 2YNVB 1ZKPA 5LCHA 2BIBA 3WXCA 2P4ZA 5A0VA 4ZNBA 3IELA 2GKLA 4D1VA 2BFLA 4P62A 5AHRA 2BG8B 5EWAA 4AX0B 2UYXA 4GCWA 3F9OA 4EY2A 3FCZA 4RL0A 3MD7A 5ACWA 4C1DA 4HKYA 1KO2A 4XUKA
chains in the Genus database with same CATH superfamily
4UWSB 2OHIA 4UWPB 3I14A 4BP0A 2WYMC 2XF4A 1JJTA 2FM6A 4UBQA 2CG2A 2YNWA 4NQ2A 1BVTA 2CFZA 4DIKA 3I15A 2FHXA 4HL2A 1WW1A 4PDXA 4YSKA 3QH8A 4AWYB 2I7TA 5EHTA 2P18A 5HH5A 4AWZA 1XM8A 2AZ4A 3RKJA 4V0HA 5K4KA 1YCGA 1L9YA 4F6ZA 2CBNA 4F6HA 5B3RA 5K0WA 1KO3A 2FU8A 4Z60A 5EW0A 4D02A 2DOOA 1VMEA 4PVTA 3S0ZA 3AF6A 5B1UA 2YCBA 3RKKA 2Q9UA 4GYQA 4D1UA 4C1HA 4UAMA 3I0VA 4C1FA 2A7MA 4C1EA 3G1PA 2Y8AA 3IDZA 5HH4A 2BC2A 1X8IA 2BG6A 5AHOA 2ZWRA 4AV7A 4TZBA 4EYFA 2NZEA 1JJEA 5HIOA 4AXHA 2QEDA 5EVDA 4GYUA 3ZWFA 5FQAA 2WHGA 5LMCA 4NQ5A 3PY6A 1KR3A 2BR6A 2BTNA 4FR7A 2GFJA 4EYBA 5HH6A 5HIPA 4Z7RA 3BV6A 1X8HA 5ACQA 4RAMA 3ZQ4A 2YNVA 5ACVA 2ZNBA 4D1WA 2ZZIA 2DKFA 4J5FA 3FAIA 4O98A 3SD9A 1XTOA 2WYMA 4CHLA 1Y44A 4EXYA 2FU9A 3DHBA 5LCAA 3LVZA 2FU7A 3X2YA 2I7VA 1BC2A 1VJNA 3DH8A 4H0DA 5AJLA 4UA4A 5AXOA 3IE2A 2OHJA 4UWOB 4J5HA 2Q0JA 3X2ZA 5LM6A 5KILA 3I11A 3T3NA 4Z6XA 2BMIA 3SPUA 1WRAA 2Q0IA 3DHCA 1WUOA 4UWRB 3BK1A 3KL7A 2BG2A 3JXPA 4HL1A 3DHAA 5EH9A 2BFZA 4U4LA 5AXRA 2QDSA 4TZ9A 4AD9A 4Z5ZA 2CFUA 2BG7A 1DD6A 3SFPA 2Y8BA 5ACSA 4TYFA 5ACRA 5KIKA 4C1GA 5HISA 4ZO3A 4FSBA 3I13A 4Z5YA 1YCHA 3ADRA 3BC2A 1VGNA 1MQOA 4DILA 2M5CA 2YZ3A 3SW3A 4AX1B 2FHXB 3IOFA 5LLDA 2NYPA 1QH5A 3PG4A 4YSBA 3IOGA 1QH3A 2HB9A 4XWWA 4LE6A 5AYAA 2GCUA 3IEKA 3ZR9A 1ZTCA 5LS3A 1X8GA 4ZEJA 5EVKA 3KNRA 3IE0A 4YSLA 3SBLA 1A7TA 5EV8A 3AF5A 2P97A 4Z67A 3R2UA 4NQ4A 5A0TA 4KEPA 3SRXA 3T9MA 5LCFA 1ZNBA 3KNSA 2BFZB 1SMLA 2XR1A 2QINA 2WRSA 4TZFA 3IEMA 2P1EA 4XWTA 4NQ6A 4TYTA 5FQBA 5FQCA 1A8TA 5HIQA 2GMNA 2YNTA 4PVOA 3VPEA 2M5DA 2NXAA 5A87A 2WYLA 4ZO2A 2I7XA 2VW8A 3P2UA 2FK6A 5A5ZA 3T3OA 4KEQA 3Q6VA 3X2XA 4EFZA 4NURA 5LE1A 4FEKA 1DDKA 5DPXA 3RPCA 1WUPA 3ESHA 4RL2A 5B15A 4RBSA 4JO0A 5K4NA 3ZNBA 1HLKA 3PY5A 4D1TA 3H3EA 3AJ3A 5LSCA 4WD6A 2BGAA 3VQZA 2E7YA 2YNTB 2R2DA 3BK2A 1P9EA 2BFKA 2GFKA 4C1CA 2AIOA 5ACUA 1JT1A 2Q42A 4EXSA 5EVBA 2YNUA 1BMCA 5A23A 3L6NA 5ACXA 4TZEA 4RAWA 1E5DA 2YHEA 2BG8A 5K4MA 2FU6A 5ACPA 3X30A 2NZFA 2Y87A 4BZ3A 2H6AA 3IE1A 3TP9A 2OHHA 1K07A 4RM5A 1DXKA 4C09A 5IQKA 4EYLA 2QDTA 1M2XA 5ACTA 1YCFA 2ZO4A 5EV6A 2QJSA 5AEBA 3A4YA 4B87A 2YNVB 1ZKPA 5LCHA 2BIBA 3WXCA 2P4ZA 5A0VA 4ZNBA 3IELA 2GKLA 4D1VA 2BFLA 4P62A 5AHRA 2BG8B 5EWAA 4AX0B 2UYXA 4GCWA 3F9OA 4EY2A 2CG3A 3FCZA 4RL0A 3MD7A 5ACWA 4C1DA 4HKYA 1KO2A 5AIJA 4XUKA
chains in the Genus database with same CATH topology
4UWSB 2OHIA 4UWPB 3I14A 4BP0A 2WYMC 2XF4A 1JJTA 2FM6A 4UBQA 2YNWA 4NQ2A 1BVTA 4DIKA 3I15A 2FHXA 4HL2A 1WW1A 4YSKA 3QH8A 4AWYB 2I7TA 5EHTA 2P18A 5HH5A 4AWZA 1XM8A 2AZ4A 3RKJA 4V0HA 5K4KA 1YCGA 1L9YA 4F6ZA 2CBNA 4F6HA 5B3RA 5K0WA 1KO3A 2FU8A 4Z60A 5EW0A 4D02A 2DOOA 1VMEA 4PVTA 3S0ZA 3AF6A 5B1UA 2YCBA 3RKKA 2Q9UA 4GYQA 4D1UA 4C1HA 4UAMA 3I0VA 4C1FA 2A7MA 4C1EA 3G1PA 2Y8AA 3IDZA 5HH4A 2BC2A 1X8IA 2BG6A 5AHOA 2ZWRA 4TZBA 4EYFA 2NZEA 1JJEA 5HIOA 2QEDA 5EVDA 4GYUA 3ZWFA 5FQAA 2WHGA 5LMCA 4NQ5A 3PY6A 1KR3A 2BR6A 2BTNA 4FR7A 2GFJA 4EYBA 5HH6A 5HIPA 4Z7RA 3BV6A 1X8HA 5ACQA 4RAMA 3ZQ4A 2YNVA 5ACVA 2ZNBA 4D1WA 2ZZIA 2DKFA 4J5FA 3FAIA 4O98A 3SD9A 1XTOA 2WYMA 4CHLA 1Y44A 4EXYA 2FU9A 3DHBA 5LCAA 3LVZA 2FU7A 3X2YA 2I7VA 1BC2A 1VJNA 3DH8A 4H0DA 4UA4A 5AXOA 3IE2A 2OHJA 4UWOB 4J5HA 2Q0JA 3X2ZA 5LM6A 5KILA 3I11A 3T3NA 4Z6XA 2BMIA 3SPUA 1WRAA 2Q0IA 3DHCA 1WUOA 4UWRB 3BK1A 3KL7A 2BG2A 3JXPA 4HL1A 3DHAA 5EH9A 2BFZA 4U4LA 5AXRA 2QDSA 4TZ9A 4AD9A 4Z5ZA 2BG7A 1DD6A 3SFPA 2Y8BA 5ACSA 4TYFA 5ACRA 5KIKA 4C1GA 5HISA 4ZO3A 4FSBA 3I13A 4Z5YA 1YCHA 3ADRA 3BC2A 1VGNA 1MQOA 4DILA 2M5CA 2YZ3A 3SW3A 4AX1B 2FHXB 3IOFA 5LLDA 2NYPA 1QH5A 3PG4A 4YSBA 3IOGA 1QH3A 2HB9A 4XWWA 4LE6A 5AYAA 2GCUA 3IEKA 3ZR9A 1ZTCA 5LS3A 1X8GA 4ZEJA 5EVKA 3KNRA 3IE0A 4YSLA 3SBLA 1A7TA 5EV8A 3AF5A 2P97A 4Z67A 3R2UA 4NQ4A 5A0TA 4KEPA 3SRXA 3T9MA 5LCFA 1ZNBA 3KNSA 2BFZB 1SMLA 2XR1A 2QINA 2WRSA 4TZFA 3IEMA 2P1EA 4XWTA 4NQ6A 4TYTA 5FQBA 5FQCA 1A8TA 5HIQA 2GMNA 2YNTA 4PVOA 3VPEA 2M5DA 2NXAA 5A87A 2WYLA 4ZO2A 2I7XA 2VW8A 3P2UA 2FK6A 5A5ZA 3T3OA 4KEQA 3Q6VA 3X2XA 4EFZA 5LE1A 4FEKA 1DDKA 5DPXA 3RPCA 1WUPA 3ESHA 4RL2A 5B15A 4RBSA 4JO0A 5K4NA 3ZNBA 1HLKA 3PY5A 4D1TA 3H3EA 3AJ3A 5LSCA 4WD6A 2BGAA 3VQZA 2E7YA 2YNTB 2R2DA 3BK2A 1P9EA 2BFKA 2GFKA 4C1CA 2AIOA 5ACUA 1JT1A 2Q42A 4EXSA 5EVBA 2YNUA 1BMCA 3L6NA 5ACXA 4TZEA 4RAWA 1E5DA 2BG8A 5K4MA 2FU6A 5ACPA 3X30A 2NZFA 2Y87A 4BZ3A 2H6AA 3IE1A 3TP9A 2OHHA 1K07A 4RM5A 1DXKA 4C09A 5IQKA 4EYLA 2QDTA 1M2XA 5ACTA 1YCFA 2ZO4A 5EV6A 2QJSA 5AEBA 3A4YA 4B87A 2YNVB 1ZKPA 5LCHA 2BIBA 3WXCA 2P4ZA 5A0VA 4ZNBA 3IELA 2GKLA 4D1VA 2BFLA 4P62A 5AHRA 2BG8B 5EWAA 4AX0B 2UYXA 4GCWA 3F9OA 4EY2A 3FCZA 4RL0A 3MD7A 5ACWA 4C1DA 4HKYA 1KO2A 4XUKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UWS B;  2OHI A;  4UWP B;  3I14 A;  4BP0 A;  2WYM C;  2XF4 A;  1JJT A;  2FM6 A;  4UBQ A;  2YNW A;  4NQ2 A;  1BVT A;  4DIK A;  3I15 A;  2FHX A;  4HL2 A;  1WW1 A;  4YSK A;  3QH8 A;  4AWY B;  2I7T A;  5EHT A;  2P18 A;  5HH5 A;  4AWZ A;  1XM8 A;  2AZ4 A;  3RKJ A;  4V0H A;  5K4K A;  1YCG A;  1L9Y A;  4F6Z A;  2CBN A;  4F6H A;  5B3R A;  5K0W A;  1KO3 A;  2FU8 A;  4Z60 A;  5EW0 A;  4D02 A;  2DOO A;  1VME A;  4PVT A;  3S0Z A;  3AF6 A;  5B1U A;  2YCB A;  3RKK A;  2Q9U A;  4GYQ A;  4D1U A;  4C1H A;  4UAM A;  3I0V A;  4C1F A;  2A7M A;  4C1E A;  3G1P A;  2Y8A A;  3IDZ A;  5HH4 A;  2BC2 A;  1X8I A;  2BG6 A;  5AHO A;  2ZWR A;  4TZB A;  4EYF A;  2NZE A;  1JJE A;  5HIO A;  2QED A;  5EVD A;  4GYU A;  3ZWF A;  5FQA A;  2WHG A;  5LMC A;  4NQ5 A;  3PY6 A;  1KR3 A;  2BR6 A;  2BTN A;  4FR7 A;  2GFJ A;  4EYB A;  5HH6 A;  5HIP A;  4Z7R A;  3BV6 A;  1X8H A;  5ACQ A;  4RAM A;  3ZQ4 A;  2YNV A;  5ACV A;  2ZNB A;  4D1W A;  2ZZI A;  2DKF A;  4J5F A;  3FAI A;  4O98 A;  3SD9 A;  1XTO A;  2WYM A;  4CHL A;  1Y44 A;  4EXY A;  2FU9 A;  3DHB A;  5LCA A;  3LVZ A;  2FU7 A;  3X2Y A;  2I7V A;  1BC2 A;  1VJN A;  3DH8 A;  4H0D A;  4UA4 A;  5AXO A;  3IE2 A;  2OHJ A;  4UWO B;  4J5H A;  2Q0J A;  3X2Z A;  5LM6 A;  5KIL A;  3I11 A;  3T3N A;  4Z6X A;  2BMI A;  3SPU A;  1WRA A;  2Q0I A;  3DHC A;  1WUO A;  4UWR B;  3BK1 A;  3KL7 A;  2BG2 A;  3JXP A;  4HL1 A;  3DHA A;  5EH9 A;  2BFZ A;  4U4L A;  5AXR A;  2QDS A;  4TZ9 A;  4AD9 A;  4Z5Z A;  2BG7 A;  1DD6 A;  3SFP A;  2Y8B A;  5ACS A;  4TYF A;  5ACR A;  5KIK A;  4C1G A;  5HIS A;  4ZO3 A;  4FSB A;  3I13 A;  4Z5Y A;  1YCH A;  3ADR A;  3BC2 A;  1VGN A;  1MQO A;  4DIL A;  2M5C A;  2YZ3 A;  3SW3 A;  4AX1 B;  2FHX B;  3IOF A;  5LLD A;  2NYP A;  1QH5 A;  3PG4 A;  4YSB A;  3IOG A;  1QH3 A;  2HB9 A;  4XWW A;  4LE6 A;  5AYA A;  2GCU A;  3IEK A;  3ZR9 A;  1ZTC A;  5LS3 A;  1X8G A;  4ZEJ A;  5EVK A;  3KNR A;  3IE0 A;  4YSL A;  3SBL A;  1A7T A;  5EV8 A;  3AF5 A;  2P97 A;  4Z67 A;  3R2U A;  4NQ4 A;  5A0T A;  4KEP A;  3SRX A;  3T9M A;  5LCF A;  1ZNB A;  3KNS A;  2BFZ B;  1SML A;  2XR1 A;  2QIN A;  2WRS A;  4TZF A;  3IEM A;  2P1E A;  4XWT A;  4NQ6 A;  4TYT A;  5FQB A;  5FQC A;  1A8T A;  5HIQ A;  2GMN A;  2YNT A;  4PVO A;  3VPE A;  2M5D A;  2NXA A;  5A87 A;  2WYL A;  4ZO2 A;  2I7X A;  2VW8 A;  3P2U A;  2FK6 A;  5A5Z A;  3T3O A;  4KEQ A;  3Q6V A;  3X2X A;  4EFZ A;  5LE1 A;  4FEK A;  1DDK A;  5DPX A;  3RPC A;  1WUP A;  3ESH A;  4RL2 A;  5B15 A;  4RBS A;  4JO0 A;  5K4N A;  3ZNB A;  1HLK A;  3PY5 A;  4D1T A;  3H3E A;  3AJ3 A;  5LSC A;  4WD6 A;  2BGA A;  3VQZ A;  2E7Y A;  2YNT B;  2R2D A;  3BK2 A;  1P9E A;  2BFK A;  2GFK A;  4C1C A;  2AIO A;  5ACU A;  1JT1 A;  2Q42 A;  4EXS A;  5EVB A;  2YNU A;  1BMC A;  3L6N A;  5ACX A;  4TZE A;  4RAW A;  1E5D A;  2BG8 A;  5K4M A;  2FU6 A;  5ACP A;  3X30 A;  2NZF A;  2Y87 A;  4BZ3 A;  2H6A A;  3IE1 A;  3TP9 A;  2OHH A;  1K07 A;  4RM5 A;  1DXK A;  4C09 A;  5IQK A;  4EYL A;  2QDT A;  1M2X A;  5ACT A;  1YCF A;  2ZO4 A;  5EV6 A;  2QJS A;  5AEB A;  3A4Y A;  4B87 A;  2YNV B;  1ZKP A;  5LCH A;  2BIB A;  3WXC A;  2P4Z A;  5A0V A;  4ZNB A;  3IEL A;  2GKL A;  4D1V A;  2BFL A;  4P62 A;  5AHR A;  2BG8 B;  5EWA A;  4AX0 B;  2UYX A;  4GCW A;  3F9O A;  4EY2 A;  3FCZ A;  4RL0 A;  3MD7 A;  5ACW A;  4C1D A;  4HKY A;  1KO2 A;  4XUK A; 
#chains in the Genus database with same CATH topology
 4UWS B;  2OHI A;  4UWP B;  3I14 A;  4BP0 A;  2WYM C;  2XF4 A;  1JJT A;  2FM6 A;  4UBQ A;  2CG2 A;  2YNW A;  4NQ2 A;  1BVT A;  2CFZ A;  4DIK A;  3I15 A;  2FHX A;  4HL2 A;  1WW1 A;  4PDX A;  4YSK A;  3QH8 A;  4AWY B;  2I7T A;  5EHT A;  2P18 A;  5HH5 A;  4AWZ A;  1XM8 A;  2AZ4 A;  3RKJ A;  4V0H A;  5K4K A;  1YCG A;  1L9Y A;  4F6Z A;  2CBN A;  4F6H A;  5B3R A;  5K0W A;  1KO3 A;  2FU8 A;  4Z60 A;  5EW0 A;  4D02 A;  2DOO A;  1VME A;  4PVT A;  3S0Z A;  3AF6 A;  5B1U A;  2YCB A;  3RKK A;  2Q9U A;  4GYQ A;  4D1U A;  4C1H A;  4UAM A;  3I0V A;  4C1F A;  2A7M A;  4C1E A;  3G1P A;  2Y8A A;  3IDZ A;  5HH4 A;  2BC2 A;  1X8I A;  2BG6 A;  5AHO A;  2ZWR A;  4AV7 A;  4TZB A;  4EYF A;  2NZE A;  1JJE A;  5HIO A;  4AXH A;  2QED A;  5EVD A;  4GYU A;  3ZWF A;  5FQA A;  2WHG A;  5LMC A;  4NQ5 A;  3PY6 A;  1KR3 A;  2BR6 A;  2BTN A;  4FR7 A;  2GFJ A;  4EYB A;  5HH6 A;  5HIP A;  4Z7R A;  3BV6 A;  1X8H A;  5ACQ A;  4RAM A;  3ZQ4 A;  2YNV A;  5ACV A;  2ZNB A;  4D1W A;  2ZZI A;  2DKF A;  4J5F A;  3FAI A;  4O98 A;  3SD9 A;  1XTO A;  2WYM A;  4CHL A;  1Y44 A;  4EXY A;  2FU9 A;  3DHB A;  5LCA A;  3LVZ A;  2FU7 A;  3X2Y A;  2I7V A;  1BC2 A;  1VJN A;  3DH8 A;  4H0D A;  5AJL A;  4UA4 A;  5AXO A;  3IE2 A;  2OHJ A;  4UWO B;  4J5H A;  2Q0J A;  3X2Z A;  5LM6 A;  5KIL A;  3I11 A;  3T3N A;  4Z6X A;  2BMI A;  3SPU A;  1WRA A;  2Q0I A;  3DHC A;  1WUO A;  4UWR B;  3BK1 A;  3KL7 A;  2BG2 A;  3JXP A;  4HL1 A;  3DHA A;  5EH9 A;  2BFZ A;  4U4L A;  5AXR A;  2QDS A;  4TZ9 A;  4AD9 A;  4Z5Z A;  2CFU A;  2BG7 A;  1DD6 A;  3SFP A;  2Y8B A;  5ACS A;  4TYF A;  5ACR A;  5KIK A;  4C1G A;  5HIS A;  4ZO3 A;  4FSB A;  3I13 A;  4Z5Y A;  1YCH A;  3ADR A;  3BC2 A;  1VGN A;  1MQO A;  4DIL A;  2M5C A;  2YZ3 A;  3SW3 A;  4AX1 B;  2FHX B;  3IOF A;  5LLD A;  2NYP A;  1QH5 A;  3PG4 A;  4YSB A;  3IOG A;  1QH3 A;  2HB9 A;  4XWW A;  4LE6 A;  5AYA A;  2GCU A;  3IEK A;  3ZR9 A;  1ZTC A;  5LS3 A;  1X8G A;  4ZEJ A;  5EVK A;  3KNR A;  3IE0 A;  4YSL A;  3SBL A;  1A7T A;  5EV8 A;  3AF5 A;  2P97 A;  4Z67 A;  3R2U A;  4NQ4 A;  5A0T A;  4KEP A;  3SRX A;  3T9M A;  5LCF A;  1ZNB A;  3KNS A;  2BFZ B;  1SML A;  2XR1 A;  2QIN A;  2WRS A;  4TZF A;  3IEM A;  2P1E A;  4XWT A;  4NQ6 A;  4TYT A;  5FQB A;  5FQC A;  1A8T A;  5HIQ A;  2GMN A;  2YNT A;  4PVO A;  3VPE A;  2M5D A;  2NXA A;  5A87 A;  2WYL A;  4ZO2 A;  2I7X A;  2VW8 A;  3P2U A;  2FK6 A;  5A5Z A;  3T3O A;  4KEQ A;  3Q6V A;  3X2X A;  4EFZ A;  4NUR A;  5LE1 A;  4FEK A;  1DDK A;  5DPX A;  3RPC A;  1WUP A;  3ESH A;  4RL2 A;  5B15 A;  4RBS A;  4JO0 A;  5K4N A;  3ZNB A;  1HLK A;  3PY5 A;  4D1T A;  3H3E A;  3AJ3 A;  5LSC A;  4WD6 A;  2BGA A;  3VQZ A;  2E7Y A;  2YNT B;  2R2D A;  3BK2 A;  1P9E A;  2BFK A;  2GFK A;  4C1C A;  2AIO A;  5ACU A;  1JT1 A;  2Q42 A;  4EXS A;  5EVB A;  2YNU A;  1BMC A;  5A23 A;  3L6N A;  5ACX A;  4TZE A;  4RAW A;  1E5D A;  2YHE A;  2BG8 A;  5K4M A;  2FU6 A;  5ACP A;  3X30 A;  2NZF A;  2Y87 A;  4BZ3 A;  2H6A A;  3IE1 A;  3TP9 A;  2OHH A;  1K07 A;  4RM5 A;  1DXK A;  4C09 A;  5IQK A;  4EYL A;  2QDT A;  1M2X A;  5ACT A;  1YCF A;  2ZO4 A;  5EV6 A;  2QJS A;  5AEB A;  3A4Y A;  4B87 A;  2YNV B;  1ZKP A;  5LCH A;  2BIB A;  3WXC A;  2P4Z A;  5A0V A;  4ZNB A;  3IEL A;  2GKL A;  4D1V A;  2BFL A;  4P62 A;  5AHR A;  2BG8 B;  5EWA A;  4AX0 B;  2UYX A;  4GCW A;  3F9O A;  4EY2 A;  2CG3 A;  3FCZ A;  4RL0 A;  3MD7 A;  5ACW A;  4C1D A;  4HKY A;  1KO2 A;  5AIJ A;  4XUK A; 
#chains in the Genus database with same CATH homology
 4UWS B;  2OHI A;  4UWP B;  3I14 A;  4BP0 A;  2WYM C;  2XF4 A;  1JJT A;  2FM6 A;  4UBQ A;  2YNW A;  4NQ2 A;  1BVT A;  4DIK A;  3I15 A;  2FHX A;  4HL2 A;  1WW1 A;  4YSK A;  3QH8 A;  4AWY B;  2I7T A;  5EHT A;  2P18 A;  5HH5 A;  4AWZ A;  1XM8 A;  2AZ4 A;  3RKJ A;  4V0H A;  5K4K A;  1YCG A;  1L9Y A;  4F6Z A;  2CBN A;  4F6H A;  5B3R A;  5K0W A;  1KO3 A;  2FU8 A;  4Z60 A;  5EW0 A;  4D02 A;  2DOO A;  1VME A;  4PVT A;  3S0Z A;  3AF6 A;  5B1U A;  2YCB A;  3RKK A;  2Q9U A;  4GYQ A;  4D1U A;  4C1H A;  4UAM A;  3I0V A;  4C1F A;  2A7M A;  4C1E A;  3G1P A;  2Y8A A;  3IDZ A;  5HH4 A;  2BC2 A;  1X8I A;  2BG6 A;  5AHO A;  2ZWR A;  4TZB A;  4EYF A;  2NZE A;  1JJE A;  5HIO A;  2QED A;  5EVD A;  4GYU A;  3ZWF A;  5FQA A;  2WHG A;  5LMC A;  4NQ5 A;  3PY6 A;  1KR3 A;  2BR6 A;  2BTN A;  4FR7 A;  2GFJ A;  4EYB A;  5HH6 A;  5HIP A;  4Z7R A;  3BV6 A;  1X8H A;  5ACQ A;  4RAM A;  3ZQ4 A;  2YNV A;  5ACV A;  2ZNB A;  4D1W A;  2ZZI A;  2DKF A;  4J5F A;  3FAI A;  4O98 A;  3SD9 A;  1XTO A;  2WYM A;  4CHL A;  1Y44 A;  4EXY A;  2FU9 A;  3DHB A;  5LCA A;  3LVZ A;  2FU7 A;  3X2Y A;  2I7V A;  1BC2 A;  1VJN A;  3DH8 A;  4H0D A;  4UA4 A;  5AXO A;  3IE2 A;  2OHJ A;  4UWO B;  4J5H A;  2Q0J A;  3X2Z A;  5LM6 A;  5KIL A;  3I11 A;  3T3N A;  4Z6X A;  2BMI A;  3SPU A;  1WRA A;  2Q0I A;  3DHC A;  1WUO A;  4UWR B;  3BK1 A;  3KL7 A;  2BG2 A;  3JXP A;  4HL1 A;  3DHA A;  5EH9 A;  2BFZ A;  4U4L A;  5AXR A;  2QDS A;  4TZ9 A;  4AD9 A;  4Z5Z A;  2BG7 A;  1DD6 A;  3SFP A;  2Y8B A;  5ACS A;  4TYF A;  5ACR A;  5KIK A;  4C1G A;  5HIS A;  4ZO3 A;  4FSB A;  3I13 A;  4Z5Y A;  1YCH A;  3ADR A;  3BC2 A;  1VGN A;  1MQO A;  4DIL A;  2M5C A;  2YZ3 A;  3SW3 A;  4AX1 B;  2FHX B;  3IOF A;  5LLD A;  2NYP A;  1QH5 A;  3PG4 A;  4YSB A;  3IOG A;  1QH3 A;  2HB9 A;  4XWW A;  4LE6 A;  5AYA A;  2GCU A;  3IEK A;  3ZR9 A;  1ZTC A;  5LS3 A;  1X8G A;  4ZEJ A;  5EVK A;  3KNR A;  3IE0 A;  4YSL A;  3SBL A;  1A7T A;  5EV8 A;  3AF5 A;  2P97 A;  4Z67 A;  3R2U A;  4NQ4 A;  5A0T A;  4KEP A;  3SRX A;  3T9M A;  5LCF A;  1ZNB A;  3KNS A;  2BFZ B;  1SML A;  2XR1 A;  2QIN A;  2WRS A;  4TZF A;  3IEM A;  2P1E A;  4XWT A;  4NQ6 A;  4TYT A;  5FQB A;  5FQC A;  1A8T A;  5HIQ A;  2GMN A;  2YNT A;  4PVO A;  3VPE A;  2M5D A;  2NXA A;  5A87 A;  2WYL A;  4ZO2 A;  2I7X A;  2VW8 A;  3P2U A;  2FK6 A;  5A5Z A;  3T3O A;  4KEQ A;  3Q6V A;  3X2X A;  4EFZ A;  5LE1 A;  4FEK A;  1DDK A;  5DPX A;  3RPC A;  1WUP A;  3ESH A;  4RL2 A;  5B15 A;  4RBS A;  4JO0 A;  5K4N A;  3ZNB A;  1HLK A;  3PY5 A;  4D1T A;  3H3E A;  3AJ3 A;  5LSC A;  4WD6 A;  2BGA A;  3VQZ A;  2E7Y A;  2YNT B;  2R2D A;  3BK2 A;  1P9E A;  2BFK A;  2GFK A;  4C1C A;  2AIO A;  5ACU A;  1JT1 A;  2Q42 A;  4EXS A;  5EVB A;  2YNU A;  1BMC A;  3L6N A;  5ACX A;  4TZE A;  4RAW A;  1E5D A;  2BG8 A;  5K4M A;  2FU6 A;  5ACP A;  3X30 A;  2NZF A;  2Y87 A;  4BZ3 A;  2H6A A;  3IE1 A;  3TP9 A;  2OHH A;  1K07 A;  4RM5 A;  1DXK A;  4C09 A;  5IQK A;  4EYL A;  2QDT A;  1M2X A;  5ACT A;  1YCF A;  2ZO4 A;  5EV6 A;  2QJS A;  5AEB A;  3A4Y A;  4B87 A;  2YNV B;  1ZKP A;  5LCH A;  2BIB A;  3WXC A;  2P4Z A;  5A0V A;  4ZNB A;  3IEL A;  2GKL A;  4D1V A;  2BFL A;  4P62 A;  5AHR A;  2BG8 B;  5EWA A;  4AX0 B;  2UYX A;  4GCW A;  3F9O A;  4EY2 A;  3FCZ A;  4RL0 A;  3MD7 A;  5ACW A;  4C1D A;  4HKY A;  1KO2 A;  4XUK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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