5EH9A

Indirect contributions of mutations underlie optimization of new enzyme function
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
253
structure length
253
Chain Sequence
GHMATVKKLYFVPAGRCMLDHSSVNSALTPGKLLNLPVWCYLLETEEGPILVDTGMPESAVNNEGLFNGTFVEGQILPKMTEEDRIVNILKRVGYEPDDLLYIISSHLHFDHAGGNGAFTNTPIIVQRTEYEAALHREEYMKECILPHLNYKIIEGDYEVVPGVQLLYTPGHSPGHQSLFIETEQSGSVLLTIDASYTKENFEDEVPFAGFDPELALSSIKRLKEVVKKEKPIIFFGHDIEQEKSCRVFPEYI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
pubmed doi rcsb
molecule tags Hydrolase
source organism Bacillus thuringiensis subsp. kurstaki
molecule keywords N-acyl homoserine lactonase AiiA
total genus 81
structure length 253
sequence length 253
ec nomenclature ec 3.1.1.81: Quorum-quenching N-acyl-homoserine lactonase.
pdb deposition date 2015-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00753 Lactamase_B Metallo-beta-lactamase superfamily
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase; Chain A Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 5eh9A01
2NZEA 3F9OA 1M2XA 1XTOA 3KL7A 4GCWA 5EVKA 1QH5A 4YSKA 5ACTA 4LE6A 2FM6A 4J5FA 4UA4A 3L6NA 2XR1A 5FQBA 3X2ZA 3IOFA 4PVOA 2YCBA 5KIKA 3IEKA 3Q6VA 4D1UA 1SMLA 4BP0A 2WYMC 2WHGA 2YNVB 1P9EA 4UWOB 2FU6A 2H6AA 1VGNA 3RKJA 3IELA 3ESHA 3I0VA 5HH6A 2ZWRA 2BG6A 3SW3A 1JJEA 3IEMA 3RKKA 4H0DA 3DH8A 2VW8A 2QDTA 3T3NA 3ZR9A 5EV8A 3VPEA 5ACUA 5EVDA 4ZO2A 4TYTA 3IOGA 5ACWA 4AWYB 3ZQ4A 4EFZA 4HL1A 4XUKA 4BZ3A 5LMCA 5B3RA 3WXCA 4UWRB 2WRSA 4F6HA 4FR7A 5K4KA 2DOOA 3I13A 4U4LA 2GMNA 2NZFA 5A5ZA 2Y8BA 5EH9A 4FEKA 1X8IA 2QDSA 1E5DA 4FSBA 5HIQA 5EV6A 1L9YA 3FAIA 5HH4A 4Z67A 5AHOA 1ZTCA 2FU7A 5LCAA 2BFKA 2QJSA 4C1FA 2CBNA 3TP9A 4EYFA 3MD7A 4EYBA 4NQ6A 4Z60A 2BFZB 2BG7A 3FCZA 4PVTA 2YZ3A 2YNVA 3R2UA 5ACVA 3X2YA 3G1PA 1KO3A 2FHXB 2GKLA 4EYLA 1KR3A 2QINA 2WYMA 1BMCA 5HIOA 5B1UA 3JXPA 5A0TA 4TYFA 4AD9A 1JT1A 5A87A 3SD9A 4TZBA 2BR6A 3DHCA 1WW1A 1DXKA 3DHBA 5AXOA 2P97A 4B87A 5ACRA 5FQCA 3T3OA 1X8GA 4EY2A 4Z5YA 5EW0A 5ACXA 4P62A 4V0HA 2P4ZA 4D1WA 2ZZIA 3ZWFA 1X8HA 3SRXA 3QH8A 2AIOA 3LVZA 1MQOA 4C1DA 4EXSA 5AXRA 2GCUA 2M5DA 5LM6A 5HIPA 5ACPA 4GYQA 2BMIA 3I15A 4TZEA 5IQKA 2UYXA 1DDKA 2AZ4A 2YNTB 3VQZA 3A4YA 4RAWA 2P1EA 4YSLA 3IDZA 2Q42A 3IE0A 4KEQA 4ZEJA 2I7XA 4C09A 1VJNA 2BFZA 4D1TA 2WYLA 3IE2A 5AYAA 3AF6A 3AJ3A 5A0VA 5K4MA 2ZNBA 2Y87A 2OHIA 2FHXA 5B15A 4F6ZA 4UWSB 4XWTA 2I7VA 1QH3A 1JJTA 3AF5A 3BK2A 4Z6XA 2BIBA 1YCHA 2BG8B 4DILA 2XF4A 5EHTA 2BC2A 2OHHA 3SBLA 3ZNBA 4TZ9A 4NQ5A 4RM5A 1XM8A 2BFLA 2P18A 4KEPA 2NXAA 3BC2A 1Y44A 4GYUA 4C1CA 5K4NA 4D1VA 3X2XA 3T9MA 1ZNBA 1WRAA 4YSBA 4UAMA 2QEDA 1WUPA 4RBSA 3KNRA 1A7TA 5LS3A 2I7TA 3PY6A 5ACSA 2FU8A 4AX0B 4DIKA 2BGAA 4XWWA 4ZO3A 5AEBA 2YNWA 1YCFA 5LE1A 2M5CA 5K0WA 4HL2A 2BTNA 5KILA 5FQAA 5LCFA 4C1EA 5DPXA 5EWAA 2A7MA 5LCHA 3SFPA 3SPUA 1KO2A 3RPCA 4Z5ZA 3H3EA 2YNTA 4O98A 2DKFA 5LLDA 5EVBA 2HB9A 3PG4A 4RL0A 4CHLA 2ZO4A 3DHAA 5LSCA 2R2DA 3X30A 2YNUA 3BK1A 3PY5A 4HKYA 1BVTA 4RAMA 1VMEA 2GFKA 4UWPB 4Z7RA 3S0ZA 1BC2A 3I14A 1A8TA 2BG8A 2Q0JA 3I11A 4NQ4A 4TZFA 2FK6A 2GFJA 3KNSA 1YCGA 2Q9UA 4RL2A 4C1HA 4NQ2A 4J5HA 2Y8AA 1HLKA 1WUOA 1K07A 2NYPA 4D02A 2BG2A 2FU9A 3IE1A 4JO0A 4UBQA 5HISA 3P2UA 5AHRA 4WD6A 2E7YA 1DD6A 4EXYA 1ZKPA 4AX1B 3ADRA 5HH5A 5ACQA 4ZNBA 4AWZA 3BV6A 2OHJA 2Q0IA 4C1GA
chains in the Genus database with same CATH superfamily
2NZEA 3F9OA 1M2XA 1XTOA 3KL7A 2CG3A 4GCWA 5EVKA 1QH5A 4YSKA 5ACTA 4LE6A 2FM6A 4J5FA 4UA4A 3L6NA 2XR1A 5FQBA 3X2ZA 3IOFA 4PVOA 2YCBA 5KIKA 3IEKA 3Q6VA 4D1UA 1SMLA 4BP0A 2WYMC 2WHGA 2CFUA 2YNVB 1P9EA 4UWOB 2FU6A 2H6AA 1VGNA 3RKJA 3IELA 3ESHA 3I0VA 5HH6A 2ZWRA 2BG6A 3SW3A 1JJEA 3IEMA 3RKKA 4H0DA 3DH8A 2VW8A 2QDTA 3T3NA 3ZR9A 5EV8A 3VPEA 5ACUA 5EVDA 4ZO2A 4TYTA 3IOGA 5ACWA 4AWYB 3ZQ4A 4EFZA 4HL1A 4XUKA 4BZ3A 5LMCA 5B3RA 3WXCA 4UWRB 2WRSA 4F6HA 4FR7A 5K4KA 2DOOA 3I13A 4U4LA 2GMNA 2NZFA 5A5ZA 2Y8BA 4AXHA 5EH9A 4FEKA 1X8IA 2QDSA 1E5DA 4FSBA 5HIQA 5EV6A 1L9YA 3FAIA 5HH4A 4Z67A 5AHOA 1ZTCA 2FU7A 5LCAA 2BFKA 2QJSA 4C1FA 2CBNA 3TP9A 4EYFA 3MD7A 4EYBA 4NQ6A 4Z60A 2BFZB 2BG7A 3FCZA 4PVTA 2YZ3A 2YNVA 3R2UA 5ACVA 3X2YA 3G1PA 1KO3A 2FHXB 2GKLA 4EYLA 1KR3A 2QINA 2WYMA 1BMCA 5HIOA 5B1UA 3JXPA 5A0TA 4TYFA 4AD9A 1JT1A 5A87A 3SD9A 4TZBA 5A23A 2BR6A 3DHCA 1WW1A 1DXKA 3DHBA 5AXOA 2P97A 4B87A 5ACRA 5FQCA 3T3OA 2CG2A 1X8GA 4EY2A 4Z5YA 5EW0A 5ACXA 4P62A 4V0HA 2P4ZA 4D1WA 2ZZIA 3ZWFA 1X8HA 3SRXA 3QH8A 2AIOA 3LVZA 1MQOA 4C1DA 4EXSA 5AXRA 2GCUA 2M5DA 5LM6A 5HIPA 5ACPA 4GYQA 2BMIA 3I15A 4TZEA 5IQKA 2UYXA 1DDKA 2AZ4A 2YNTB 3VQZA 3A4YA 4PDXA 4AV7A 4RAWA 2P1EA 4YSLA 3IDZA 2Q42A 3IE0A 4KEQA 4ZEJA 2I7XA 4C09A 1VJNA 2BFZA 4D1TA 2WYLA 3IE2A 5AYAA 3AF6A 3AJ3A 5A0VA 5K4MA 2ZNBA 2Y87A 2OHIA 2FHXA 5B15A 4F6ZA 4UWSB 4XWTA 2I7VA 1QH3A 2CFZA 1JJTA 3AF5A 3BK2A 4Z6XA 2BIBA 1YCHA 2BG8B 4DILA 2XF4A 5EHTA 2BC2A 3ZNBA 2OHHA 3SBLA 4TZ9A 4NQ5A 4RM5A 1XM8A 2BFLA 2P18A 4KEPA 2NXAA 3BC2A 1Y44A 4GYUA 4C1CA 5K4NA 4D1VA 3X2XA 3T9MA 1ZNBA 1WRAA 4YSBA 4UAMA 2QEDA 1WUPA 4RBSA 3KNRA 1A7TA 5LS3A 2I7TA 3PY6A 5ACSA 2FU8A 4AX0B 4DIKA 2BGAA 4XWWA 4ZO3A 5AEBA 2YHEA 2YNWA 4NURA 1YCFA 5LE1A 5AIJA 2M5CA 5K0WA 4HL2A 2BTNA 5KILA 5FQAA 5LCFA 4C1EA 5DPXA 5EWAA 2A7MA 5LCHA 3SFPA 3SPUA 1KO2A 3RPCA 4Z5ZA 3H3EA 2YNTA 4O98A 2DKFA 5LLDA 5EVBA 2HB9A 3PG4A 4RL0A 4CHLA 2ZO4A 3DHAA 5LSCA 2R2DA 3X30A 2YNUA 3BK1A 3PY5A 4HKYA 1BVTA 4RAMA 1VMEA 2GFKA 4UWPB 4Z7RA 3S0ZA 1BC2A 3I14A 1A8TA 2BG8A 2Q0JA 3I11A 4NQ4A 4TZFA 2FK6A 2GFJA 3KNSA 1YCGA 2Q9UA 4RL2A 4C1HA 4NQ2A 4J5HA 5AJLA 2Y8AA 1HLKA 1WUOA 1K07A 2NYPA 4D02A 2BG2A 2FU9A 3IE1A 4JO0A 4UBQA 5HISA 3P2UA 5AHRA 4WD6A 2E7YA 1DD6A 4EXYA 1ZKPA 4AX1B 3ADRA 5HH5A 5ACQA 4ZNBA 4AWZA 3BV6A 2OHJA 2Q0IA 4C1GA
chains in the Genus database with same CATH topology
2NZEA 3F9OA 1M2XA 1XTOA 3KL7A 4GCWA 5EVKA 1QH5A 4YSKA 5ACTA 4LE6A 2FM6A 4J5FA 4UA4A 3L6NA 2XR1A 5FQBA 3X2ZA 3IOFA 4PVOA 2YCBA 5KIKA 3IEKA 3Q6VA 4D1UA 1SMLA 4BP0A 2WYMC 2WHGA 2YNVB 1P9EA 4UWOB 2FU6A 2H6AA 1VGNA 3RKJA 3IELA 3ESHA 3I0VA 5HH6A 2ZWRA 2BG6A 3SW3A 1JJEA 3IEMA 3RKKA 4H0DA 3DH8A 2VW8A 2QDTA 3T3NA 3ZR9A 5EV8A 3VPEA 5ACUA 5EVDA 4ZO2A 4TYTA 3IOGA 5ACWA 4AWYB 3ZQ4A 4EFZA 4HL1A 4XUKA 4BZ3A 5LMCA 5B3RA 3WXCA 4UWRB 2WRSA 4F6HA 4FR7A 5K4KA 2DOOA 3I13A 4U4LA 2GMNA 2NZFA 5A5ZA 2Y8BA 5EH9A 4FEKA 1X8IA 2QDSA 1E5DA 4FSBA 5HIQA 5EV6A 1L9YA 3FAIA 5HH4A 4Z67A 5AHOA 1ZTCA 2FU7A 5LCAA 2BFKA 2QJSA 4C1FA 2CBNA 3TP9A 4EYFA 3MD7A 4EYBA 4NQ6A 4Z60A 2BFZB 2BG7A 3FCZA 4PVTA 2YZ3A 2YNVA 3R2UA 5ACVA 3X2YA 3G1PA 1KO3A 2FHXB 2GKLA 4EYLA 1KR3A 2QINA 2WYMA 1BMCA 5HIOA 5B1UA 3JXPA 5A0TA 4TYFA 4AD9A 1JT1A 5A87A 3SD9A 4TZBA 2BR6A 3DHCA 1WW1A 1DXKA 3DHBA 5AXOA 2P97A 4B87A 5ACRA 5FQCA 3T3OA 1X8GA 4EY2A 4Z5YA 5EW0A 5ACXA 4P62A 4V0HA 2P4ZA 4D1WA 2ZZIA 3ZWFA 1X8HA 3SRXA 3QH8A 2AIOA 3LVZA 1MQOA 4C1DA 4EXSA 5AXRA 2GCUA 2M5DA 5LM6A 5HIPA 5ACPA 4GYQA 2BMIA 3I15A 4TZEA 5IQKA 2UYXA 1DDKA 2AZ4A 2YNTB 3VQZA 3A4YA 4RAWA 2P1EA 4YSLA 3IDZA 2Q42A 3IE0A 4KEQA 4ZEJA 2I7XA 4C09A 1VJNA 2BFZA 4D1TA 2WYLA 3IE2A 5AYAA 3AF6A 3AJ3A 5A0VA 5K4MA 2ZNBA 2Y87A 2OHIA 2FHXA 5B15A 4F6ZA 4UWSB 4XWTA 2I7VA 1QH3A 1JJTA 3AF5A 3BK2A 4Z6XA 2BIBA 1YCHA 2BG8B 4DILA 2XF4A 5EHTA 2BC2A 2OHHA 3SBLA 3ZNBA 4TZ9A 4NQ5A 4RM5A 1XM8A 2BFLA 2P18A 4KEPA 2NXAA 3BC2A 1Y44A 4GYUA 4C1CA 5K4NA 4D1VA 3X2XA 3T9MA 1ZNBA 1WRAA 4YSBA 4UAMA 2QEDA 1WUPA 4RBSA 3KNRA 1A7TA 5LS3A 2I7TA 3PY6A 5ACSA 2FU8A 4AX0B 4DIKA 2BGAA 4XWWA 4ZO3A 5AEBA 2YNWA 1YCFA 5LE1A 2M5CA 5K0WA 4HL2A 2BTNA 5KILA 5FQAA 5LCFA 4C1EA 5DPXA 5EWAA 2A7MA 5LCHA 3SFPA 3SPUA 1KO2A 3RPCA 4Z5ZA 3H3EA 2YNTA 4O98A 2DKFA 5LLDA 5EVBA 2HB9A 3PG4A 4RL0A 4CHLA 2ZO4A 3DHAA 5LSCA 2R2DA 3X30A 2YNUA 3BK1A 3PY5A 4HKYA 1BVTA 4RAMA 1VMEA 2GFKA 4UWPB 4Z7RA 3S0ZA 1BC2A 3I14A 1A8TA 2BG8A 2Q0JA 3I11A 4NQ4A 4TZFA 2FK6A 2GFJA 3KNSA 1YCGA 2Q9UA 4RL2A 4C1HA 4NQ2A 4J5HA 2Y8AA 1HLKA 1WUOA 1K07A 2NYPA 4D02A 2BG2A 2FU9A 3IE1A 4JO0A 4UBQA 5HISA 3P2UA 5AHRA 4WD6A 2E7YA 1DD6A 4EXYA 1ZKPA 4AX1B 3ADRA 5HH5A 5ACQA 4ZNBA 4AWZA 3BV6A 2OHJA 2Q0IA 4C1GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NZE A;  3F9O A;  1M2X A;  1XTO A;  3KL7 A;  4GCW A;  5EVK A;  1QH5 A;  4YSK A;  5ACT A;  4LE6 A;  2FM6 A;  4J5F A;  4UA4 A;  3L6N A;  2XR1 A;  5FQB A;  3X2Z A;  3IOF A;  4PVO A;  2YCB A;  5KIK A;  3IEK A;  3Q6V A;  4D1U A;  1SML A;  4BP0 A;  2WYM C;  2WHG A;  2YNV B;  1P9E A;  4UWO B;  2FU6 A;  2H6A A;  1VGN A;  3RKJ A;  3IEL A;  3ESH A;  3I0V A;  5HH6 A;  2ZWR A;  2BG6 A;  3SW3 A;  1JJE A;  3IEM A;  3RKK A;  4H0D A;  3DH8 A;  2VW8 A;  2QDT A;  3T3N A;  3ZR9 A;  5EV8 A;  3VPE A;  5ACU A;  5EVD A;  4ZO2 A;  4TYT A;  3IOG A;  5ACW A;  4AWY B;  3ZQ4 A;  4EFZ A;  4HL1 A;  4XUK A;  4BZ3 A;  5LMC A;  5B3R A;  3WXC A;  4UWR B;  2WRS A;  4F6H A;  4FR7 A;  5K4K A;  2DOO A;  3I13 A;  4U4L A;  2GMN A;  2NZF A;  5A5Z A;  2Y8B A;  5EH9 A;  4FEK A;  1X8I A;  2QDS A;  1E5D A;  4FSB A;  5HIQ A;  5EV6 A;  1L9Y A;  3FAI A;  5HH4 A;  4Z67 A;  5AHO A;  1ZTC A;  2FU7 A;  5LCA A;  2BFK A;  2QJS A;  4C1F A;  2CBN A;  3TP9 A;  4EYF A;  3MD7 A;  4EYB A;  4NQ6 A;  4Z60 A;  2BFZ B;  2BG7 A;  3FCZ A;  4PVT A;  2YZ3 A;  2YNV A;  3R2U A;  5ACV A;  3X2Y A;  3G1P A;  1KO3 A;  2FHX B;  2GKL A;  4EYL A;  1KR3 A;  2QIN A;  2WYM A;  1BMC A;  5HIO A;  5B1U A;  3JXP A;  5A0T A;  4TYF A;  4AD9 A;  1JT1 A;  5A87 A;  3SD9 A;  4TZB A;  2BR6 A;  3DHC A;  1WW1 A;  1DXK A;  3DHB A;  5AXO A;  2P97 A;  4B87 A;  5ACR A;  5FQC A;  3T3O A;  1X8G A;  4EY2 A;  4Z5Y A;  5EW0 A;  5ACX A;  4P62 A;  4V0H A;  2P4Z A;  4D1W A;  2ZZI A;  3ZWF A;  1X8H A;  3SRX A;  3QH8 A;  2AIO A;  3LVZ A;  1MQO A;  4C1D A;  4EXS A;  5AXR A;  2GCU A;  2M5D A;  5LM6 A;  5HIP A;  5ACP A;  4GYQ A;  2BMI A;  3I15 A;  4TZE A;  5IQK A;  2UYX A;  1DDK A;  2AZ4 A;  2YNT B;  3VQZ A;  3A4Y A;  4RAW A;  2P1E A;  4YSL A;  3IDZ A;  2Q42 A;  3IE0 A;  4KEQ A;  4ZEJ A;  2I7X A;  4C09 A;  1VJN A;  2BFZ A;  4D1T A;  2WYL A;  3IE2 A;  5AYA A;  3AF6 A;  3AJ3 A;  5A0V A;  5K4M A;  2ZNB A;  2Y87 A;  2OHI A;  2FHX A;  5B15 A;  4F6Z A;  4UWS B;  4XWT A;  2I7V A;  1QH3 A;  1JJT A;  3AF5 A;  3BK2 A;  4Z6X A;  2BIB A;  1YCH A;  2BG8 B;  4DIL A;  2XF4 A;  5EHT A;  2BC2 A;  2OHH A;  3SBL A;  3ZNB A;  4TZ9 A;  4NQ5 A;  4RM5 A;  1XM8 A;  2BFL A;  2P18 A;  4KEP A;  2NXA A;  3BC2 A;  1Y44 A;  4GYU A;  4C1C A;  5K4N A;  4D1V A;  3X2X A;  3T9M A;  1ZNB A;  1WRA A;  4YSB A;  4UAM A;  2QED A;  1WUP A;  4RBS A;  3KNR A;  1A7T A;  5LS3 A;  2I7T A;  3PY6 A;  5ACS A;  2FU8 A;  4AX0 B;  4DIK A;  2BGA A;  4XWW A;  4ZO3 A;  5AEB A;  2YNW A;  1YCF A;  5LE1 A;  2M5C A;  5K0W A;  4HL2 A;  2BTN A;  5KIL A;  5FQA A;  5LCF A;  4C1E A;  5DPX A;  5EWA A;  2A7M A;  5LCH A;  3SFP A;  3SPU A;  1KO2 A;  3RPC A;  4Z5Z A;  3H3E A;  2YNT A;  4O98 A;  2DKF A;  5LLD A;  5EVB A;  2HB9 A;  3PG4 A;  4RL0 A;  4CHL A;  2ZO4 A;  3DHA A;  5LSC A;  2R2D A;  3X30 A;  2YNU A;  3BK1 A;  3PY5 A;  4HKY A;  1BVT A;  4RAM A;  1VME A;  2GFK A;  4UWP B;  4Z7R A;  3S0Z A;  1BC2 A;  3I14 A;  1A8T A;  2BG8 A;  2Q0J A;  3I11 A;  4NQ4 A;  4TZF A;  2FK6 A;  2GFJ A;  3KNS A;  1YCG A;  2Q9U A;  4RL2 A;  4C1H A;  4NQ2 A;  4J5H A;  2Y8A A;  1HLK A;  1WUO A;  1K07 A;  2NYP A;  4D02 A;  2BG2 A;  2FU9 A;  3IE1 A;  4JO0 A;  4UBQ A;  5HIS A;  3P2U A;  5AHR A;  4WD6 A;  2E7Y A;  1DD6 A;  4EXY A;  1ZKP A;  4AX1 B;  3ADR A;  5HH5 A;  5ACQ A;  4ZNB A;  4AWZ A;  3BV6 A;  2OHJ A;  2Q0I A;  4C1G A; 
#chains in the Genus database with same CATH topology
 2NZE A;  3F9O A;  1M2X A;  1XTO A;  3KL7 A;  2CG3 A;  4GCW A;  5EVK A;  1QH5 A;  4YSK A;  5ACT A;  4LE6 A;  2FM6 A;  4J5F A;  4UA4 A;  3L6N A;  2XR1 A;  5FQB A;  3X2Z A;  3IOF A;  4PVO A;  2YCB A;  5KIK A;  3IEK A;  3Q6V A;  4D1U A;  1SML A;  4BP0 A;  2WYM C;  2WHG A;  2CFU A;  2YNV B;  1P9E A;  4UWO B;  2FU6 A;  2H6A A;  1VGN A;  3RKJ A;  3IEL A;  3ESH A;  3I0V A;  5HH6 A;  2ZWR A;  2BG6 A;  3SW3 A;  1JJE A;  3IEM A;  3RKK A;  4H0D A;  3DH8 A;  2VW8 A;  2QDT A;  3T3N A;  3ZR9 A;  5EV8 A;  3VPE A;  5ACU A;  5EVD A;  4ZO2 A;  4TYT A;  3IOG A;  5ACW A;  4AWY B;  3ZQ4 A;  4EFZ A;  4HL1 A;  4XUK A;  4BZ3 A;  5LMC A;  5B3R A;  3WXC A;  4UWR B;  2WRS A;  4F6H A;  4FR7 A;  5K4K A;  2DOO A;  3I13 A;  4U4L A;  2GMN A;  2NZF A;  5A5Z A;  2Y8B A;  4AXH A;  5EH9 A;  4FEK A;  1X8I A;  2QDS A;  1E5D A;  4FSB A;  5HIQ A;  5EV6 A;  1L9Y A;  3FAI A;  5HH4 A;  4Z67 A;  5AHO A;  1ZTC A;  2FU7 A;  5LCA A;  2BFK A;  2QJS A;  4C1F A;  2CBN A;  3TP9 A;  4EYF A;  3MD7 A;  4EYB A;  4NQ6 A;  4Z60 A;  2BFZ B;  2BG7 A;  3FCZ A;  4PVT A;  2YZ3 A;  2YNV A;  3R2U A;  5ACV A;  3X2Y A;  3G1P A;  1KO3 A;  2FHX B;  2GKL A;  4EYL A;  1KR3 A;  2QIN A;  2WYM A;  1BMC A;  5HIO A;  5B1U A;  3JXP A;  5A0T A;  4TYF A;  4AD9 A;  1JT1 A;  5A87 A;  3SD9 A;  4TZB A;  5A23 A;  2BR6 A;  3DHC A;  1WW1 A;  1DXK A;  3DHB A;  5AXO A;  2P97 A;  4B87 A;  5ACR A;  5FQC A;  3T3O A;  2CG2 A;  1X8G A;  4EY2 A;  4Z5Y A;  5EW0 A;  5ACX A;  4P62 A;  4V0H A;  2P4Z A;  4D1W A;  2ZZI A;  3ZWF A;  1X8H A;  3SRX A;  3QH8 A;  2AIO A;  3LVZ A;  1MQO A;  4C1D A;  4EXS A;  5AXR A;  2GCU A;  2M5D A;  5LM6 A;  5HIP A;  5ACP A;  4GYQ A;  2BMI A;  3I15 A;  4TZE A;  5IQK A;  2UYX A;  1DDK A;  2AZ4 A;  2YNT B;  3VQZ A;  3A4Y A;  4PDX A;  4AV7 A;  4RAW A;  2P1E A;  4YSL A;  3IDZ A;  2Q42 A;  3IE0 A;  4KEQ A;  4ZEJ A;  2I7X A;  4C09 A;  1VJN A;  2BFZ A;  4D1T A;  2WYL A;  3IE2 A;  5AYA A;  3AF6 A;  3AJ3 A;  5A0V A;  5K4M A;  2ZNB A;  2Y87 A;  2OHI A;  2FHX A;  5B15 A;  4F6Z A;  4UWS B;  4XWT A;  2I7V A;  1QH3 A;  2CFZ A;  1JJT A;  3AF5 A;  3BK2 A;  4Z6X A;  2BIB A;  1YCH A;  2BG8 B;  4DIL A;  2XF4 A;  5EHT A;  2BC2 A;  3ZNB A;  2OHH A;  3SBL A;  4TZ9 A;  4NQ5 A;  4RM5 A;  1XM8 A;  2BFL A;  2P18 A;  4KEP A;  2NXA A;  3BC2 A;  1Y44 A;  4GYU A;  4C1C A;  5K4N A;  4D1V A;  3X2X A;  3T9M A;  1ZNB A;  1WRA A;  4YSB A;  4UAM A;  2QED A;  1WUP A;  4RBS A;  3KNR A;  1A7T A;  5LS3 A;  2I7T A;  3PY6 A;  5ACS A;  2FU8 A;  4AX0 B;  4DIK A;  2BGA A;  4XWW A;  4ZO3 A;  5AEB A;  2YHE A;  2YNW A;  4NUR A;  1YCF A;  5LE1 A;  5AIJ A;  2M5C A;  5K0W A;  4HL2 A;  2BTN A;  5KIL A;  5FQA A;  5LCF A;  4C1E A;  5DPX A;  5EWA A;  2A7M A;  5LCH A;  3SFP A;  3SPU A;  1KO2 A;  3RPC A;  4Z5Z A;  3H3E A;  2YNT A;  4O98 A;  2DKF A;  5LLD A;  5EVB A;  2HB9 A;  3PG4 A;  4RL0 A;  4CHL A;  2ZO4 A;  3DHA A;  5LSC A;  2R2D A;  3X30 A;  2YNU A;  3BK1 A;  3PY5 A;  4HKY A;  1BVT A;  4RAM A;  1VME A;  2GFK A;  4UWP B;  4Z7R A;  3S0Z A;  1BC2 A;  3I14 A;  1A8T A;  2BG8 A;  2Q0J A;  3I11 A;  4NQ4 A;  4TZF A;  2FK6 A;  2GFJ A;  3KNS A;  1YCG A;  2Q9U A;  4RL2 A;  4C1H A;  4NQ2 A;  4J5H A;  5AJL A;  2Y8A A;  1HLK A;  1WUO A;  1K07 A;  2NYP A;  4D02 A;  2BG2 A;  2FU9 A;  3IE1 A;  4JO0 A;  4UBQ A;  5HIS A;  3P2U A;  5AHR A;  4WD6 A;  2E7Y A;  1DD6 A;  4EXY A;  1ZKP A;  4AX1 B;  3ADR A;  5HH5 A;  5ACQ A;  4ZNB A;  4AWZ A;  3BV6 A;  2OHJ A;  2Q0I A;  4C1G A; 
#chains in the Genus database with same CATH homology
 2NZE A;  3F9O A;  1M2X A;  1XTO A;  3KL7 A;  4GCW A;  5EVK A;  1QH5 A;  4YSK A;  5ACT A;  4LE6 A;  2FM6 A;  4J5F A;  4UA4 A;  3L6N A;  2XR1 A;  5FQB A;  3X2Z A;  3IOF A;  4PVO A;  2YCB A;  5KIK A;  3IEK A;  3Q6V A;  4D1U A;  1SML A;  4BP0 A;  2WYM C;  2WHG A;  2YNV B;  1P9E A;  4UWO B;  2FU6 A;  2H6A A;  1VGN A;  3RKJ A;  3IEL A;  3ESH A;  3I0V A;  5HH6 A;  2ZWR A;  2BG6 A;  3SW3 A;  1JJE A;  3IEM A;  3RKK A;  4H0D A;  3DH8 A;  2VW8 A;  2QDT A;  3T3N A;  3ZR9 A;  5EV8 A;  3VPE A;  5ACU A;  5EVD A;  4ZO2 A;  4TYT A;  3IOG A;  5ACW A;  4AWY B;  3ZQ4 A;  4EFZ A;  4HL1 A;  4XUK A;  4BZ3 A;  5LMC A;  5B3R A;  3WXC A;  4UWR B;  2WRS A;  4F6H A;  4FR7 A;  5K4K A;  2DOO A;  3I13 A;  4U4L A;  2GMN A;  2NZF A;  5A5Z A;  2Y8B A;  5EH9 A;  4FEK A;  1X8I A;  2QDS A;  1E5D A;  4FSB A;  5HIQ A;  5EV6 A;  1L9Y A;  3FAI A;  5HH4 A;  4Z67 A;  5AHO A;  1ZTC A;  2FU7 A;  5LCA A;  2BFK A;  2QJS A;  4C1F A;  2CBN A;  3TP9 A;  4EYF A;  3MD7 A;  4EYB A;  4NQ6 A;  4Z60 A;  2BFZ B;  2BG7 A;  3FCZ A;  4PVT A;  2YZ3 A;  2YNV A;  3R2U A;  5ACV A;  3X2Y A;  3G1P A;  1KO3 A;  2FHX B;  2GKL A;  4EYL A;  1KR3 A;  2QIN A;  2WYM A;  1BMC A;  5HIO A;  5B1U A;  3JXP A;  5A0T A;  4TYF A;  4AD9 A;  1JT1 A;  5A87 A;  3SD9 A;  4TZB A;  2BR6 A;  3DHC A;  1WW1 A;  1DXK A;  3DHB A;  5AXO A;  2P97 A;  4B87 A;  5ACR A;  5FQC A;  3T3O A;  1X8G A;  4EY2 A;  4Z5Y A;  5EW0 A;  5ACX A;  4P62 A;  4V0H A;  2P4Z A;  4D1W A;  2ZZI A;  3ZWF A;  1X8H A;  3SRX A;  3QH8 A;  2AIO A;  3LVZ A;  1MQO A;  4C1D A;  4EXS A;  5AXR A;  2GCU A;  2M5D A;  5LM6 A;  5HIP A;  5ACP A;  4GYQ A;  2BMI A;  3I15 A;  4TZE A;  5IQK A;  2UYX A;  1DDK A;  2AZ4 A;  2YNT B;  3VQZ A;  3A4Y A;  4RAW A;  2P1E A;  4YSL A;  3IDZ A;  2Q42 A;  3IE0 A;  4KEQ A;  4ZEJ A;  2I7X A;  4C09 A;  1VJN A;  2BFZ A;  4D1T A;  2WYL A;  3IE2 A;  5AYA A;  3AF6 A;  3AJ3 A;  5A0V A;  5K4M A;  2ZNB A;  2Y87 A;  2OHI A;  2FHX A;  5B15 A;  4F6Z A;  4UWS B;  4XWT A;  2I7V A;  1QH3 A;  1JJT A;  3AF5 A;  3BK2 A;  4Z6X A;  2BIB A;  1YCH A;  2BG8 B;  4DIL A;  2XF4 A;  5EHT A;  2BC2 A;  2OHH A;  3SBL A;  3ZNB A;  4TZ9 A;  4NQ5 A;  4RM5 A;  1XM8 A;  2BFL A;  2P18 A;  4KEP A;  2NXA A;  3BC2 A;  1Y44 A;  4GYU A;  4C1C A;  5K4N A;  4D1V A;  3X2X A;  3T9M A;  1ZNB A;  1WRA A;  4YSB A;  4UAM A;  2QED A;  1WUP A;  4RBS A;  3KNR A;  1A7T A;  5LS3 A;  2I7T A;  3PY6 A;  5ACS A;  2FU8 A;  4AX0 B;  4DIK A;  2BGA A;  4XWW A;  4ZO3 A;  5AEB A;  2YNW A;  1YCF A;  5LE1 A;  2M5C A;  5K0W A;  4HL2 A;  2BTN A;  5KIL A;  5FQA A;  5LCF A;  4C1E A;  5DPX A;  5EWA A;  2A7M A;  5LCH A;  3SFP A;  3SPU A;  1KO2 A;  3RPC A;  4Z5Z A;  3H3E A;  2YNT A;  4O98 A;  2DKF A;  5LLD A;  5EVB A;  2HB9 A;  3PG4 A;  4RL0 A;  4CHL A;  2ZO4 A;  3DHA A;  5LSC A;  2R2D A;  3X30 A;  2YNU A;  3BK1 A;  3PY5 A;  4HKY A;  1BVT A;  4RAM A;  1VME A;  2GFK A;  4UWP B;  4Z7R A;  3S0Z A;  1BC2 A;  3I14 A;  1A8T A;  2BG8 A;  2Q0J A;  3I11 A;  4NQ4 A;  4TZF A;  2FK6 A;  2GFJ A;  3KNS A;  1YCG A;  2Q9U A;  4RL2 A;  4C1H A;  4NQ2 A;  4J5H A;  2Y8A A;  1HLK A;  1WUO A;  1K07 A;  2NYP A;  4D02 A;  2BG2 A;  2FU9 A;  3IE1 A;  4JO0 A;  4UBQ A;  5HIS A;  3P2U A;  5AHR A;  4WD6 A;  2E7Y A;  1DD6 A;  4EXY A;  1ZKP A;  4AX1 B;  3ADR A;  5HH5 A;  5ACQ A;  4ZNB A;  4AWZ A;  3BV6 A;  2OHJ A;  2Q0I A;  4C1G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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