5EHTA

Indirect contributions of mutations underlie optimization of new enzyme function
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
253
structure length
252
Chain Sequence
GHMATVKKLYFVPAGRCMLDHSFVNSALTPGKLLNVPVWCYLLETEEGPILVDTGMPESAVNNEGLNGTFGEGQILPKMTEEDRIVNILKRVGYEPDDLLYIISSHLHFDHAGGNGAFTNTPIIVQRTEYEAALHREEYMTECILPHLNYKIIEGDYEVVPGVQLLYTPGHSPGHQSLFIETEQSGSVLLTIDASYTKENFEDEVPFAGFDPELALSSIKRLKEVVKKEKPMIFFGHDIEQEKSCRVFPEYI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
pubmed doi rcsb
molecule tags Hydrolase
source organism Bacillus thuringiensis
molecule keywords N-acyl homoserine lactonase
total genus 84
structure length 252
sequence length 253
ec nomenclature ec 3.1.1.81: Quorum-quenching N-acyl-homoserine lactonase.
pdb deposition date 2015-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00753 Lactamase_B Metallo-beta-lactamase superfamily
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase; Chain A Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 5ehtA01
5EVBA 2WYMA 2NZFA 3IE2A 2FU9A 4V0HA 4RM5A 4DILA 5KIKA 4D1UA 1VMEA 2P18A 5AXOA 1QH3A 2FU8A 4J5HA 1WRAA 5K4KA 1JJTA 3IEMA 2OHHA 3WXCA 1BVTA 4RBSA 2BC2A 4XUKA 5FQAA 1KO2A 2QDTA 3RPCA 5AHOA 4YSLA 2M5DA 4UAMA 4C1GA 2Q9UA 3H3EA 5KILA 3DHCA 5LLDA 1BC2A 4DIKA 2BG8A 4UWOB 2BG7A 2BG2A 4O98A 5EV8A 2YNVA 2YZ3A 3BV6A 4UWRB 1YCGA 4C1FA 3IE1A 5A0TA 3PG4A 3T3NA 2E7YA 4EY2A 3L6NA 2NZEA 5ACWA 3VQZA 4CHLA 2XR1A 3PY6A 2BG6A 1Y44A 3I14A 3T9MA 5AYAA 1L9YA 2WYMC 5ACXA 5K4NA 3LVZA 2GKLA 3VPEA 4BP0A 4FR7A 5B15A 3SRXA 2NXAA 2Q0JA 2I7TA 1XTOA 2FHXB 4H0DA 1WW1A 4KEPA 5B3RA 5DPXA 4TZEA 5K4MA 1YCFA 5LMCA 1X8HA 3S0ZA 2HB9A 2YNUA 2YNTB 4C1HA 5HH6A 1XM8A 4F6HA 4GYQA 4NQ5A 5IQKA 2BFZB 2Y8AA 4P62A 5HIPA 5FQCA 3X2ZA 5HH4A 2BGAA 3DHBA 2BFKA 3X2XA 2Y8BA 3ZR9A 4UA4A 4TZ9A 1VJNA 2P4ZA 3FAIA 4EYFA 4TZFA 5EVKA 2UYXA 5EVDA 2FU7A 4D1WA 5A87A 4HKYA 3R2UA 1P9EA 4AWZA 5LE1A 3BK1A 4Z7RA 3RKJA 4LE6A 5HIOA 1JT1A 2OHJA 4JO0A 4EXSA 3F9OA 2FU6A 2WHGA 3DH8A 4RAMA 4ZEJA 2BFLA 4GCWA 1DD6A 4UBQA 3ZNBA 2GMNA 1A8TA 5ACRA 3IDZA 1ZNBA 4RL0A 1A7TA 1X8GA 1X8IA 3IOFA 2QJSA 3KNRA 2ZO4A 4AWYB 4D02A 4KEQA 1BMCA 5LSCA 3DHAA 4RAWA 1DDKA 2VW8A 4C1EA 4WD6A 3SBLA 5LCHA 2Q0IA 5FQBA 4UWSB 2BIBA 5ACSA 2XF4A 3I11A 1ZTCA 5HISA 2YNWA 1MQOA 1DXKA 3SW3A 4YSKA 5EV6A 5LM6A 3ZQ4A 3AJ3A 4B87A 5ACPA 3SD9A 4Z5ZA 3T3OA 4TYTA 2BG8B 2P1EA 4FEKA 5ACTA 2I7XA 1QH5A 4YSBA 3BK2A 4AX0B 5A0VA 3KNSA 2AIOA 1KO3A 3AF5A 4Z60A 1K07A 2YNVB 5B1UA 3ESHA 5EW0A 4AX1B 4EFZA 4ZO3A 4TYFA 2A7MA 1E5DA 3P2UA 4HL2A 5LCFA 2OHIA 2R2DA 2ZWRA 1YCHA 3TP9A 4ZNBA 4UWPB 4NQ2A 1JJEA 2FHXA 5LCAA 1HLKA 2ZZIA 3BC2A 4ZO2A 5EHTA 4Z67A 2H6AA 2BTNA 4NQ6A 4EYBA 4Z5YA 3IEKA 3ZWFA 2WRSA 2YNTA 3PY5A 3IOGA 3Q6VA 2WYLA 2BFZA 2FK6A 4HL1A 4PVOA 1SMLA 4J5FA 1WUPA 3X2YA 2M5CA 4NQ4A 2BR6A 5EH9A 3I13A 2DOOA 4C1DA 4EYLA 2NYPA 3IE0A 2GCUA 2AZ4A 4U4LA 2YCBA 2I7VA 2FM6A 5AEBA 4F6ZA 5ACQA 2GFJA 2P97A 3RKKA 3SPUA 3A4YA 3KL7A 1KR3A 4BZ3A 2GFKA 4XWTA 2DKFA 2Y87A 3IELA 5HIQA 1WUOA 4RL2A 3ADRA 2Q42A 1M2XA 5ACUA 3G1PA 2CBNA 4PVTA 2QEDA 4D1VA 5EWAA 2QINA 3AF6A 5AXRA 5HH5A 4GYUA 3X30A 2BMIA 4XWWA 4TZBA 3JXPA 1ZKPA 2QDSA 1VGNA 4C1CA 2ZNBA 3I15A 3I0VA 3FCZA 4Z6XA 5ACVA 5K0WA 5A5ZA 5AHRA 4D1TA 4FSBA 4AD9A 3SFPA 4C09A 3MD7A 5LS3A 4EXYA 3QH8A
chains in the Genus database with same CATH superfamily
5EVBA 2WYMA 2CG3A 2NZFA 3IE2A 2FU9A 4V0HA 4RM5A 4DILA 5KIKA 4D1UA 1VMEA 2P18A 5AXOA 1QH3A 2FU8A 4J5HA 1WRAA 5K4KA 1JJTA 3IEMA 2OHHA 3WXCA 1BVTA 4RBSA 2BC2A 4XUKA 5FQAA 1KO2A 2QDTA 3RPCA 5AHOA 4YSLA 2M5DA 5AIJA 4UAMA 4C1GA 2Q9UA 3H3EA 5KILA 3DHCA 5LLDA 1BC2A 4DIKA 2BG8A 4UWOB 2BG7A 2BG2A 4O98A 5EV8A 2YNVA 2YZ3A 3BV6A 4UWRB 1YCGA 4C1FA 3IE1A 5A0TA 3PG4A 3T3NA 2E7YA 4EY2A 3L6NA 2NZEA 5ACWA 3VQZA 4CHLA 2XR1A 3PY6A 2BG6A 1Y44A 4AXHA 3I14A 3T9MA 5AYAA 1L9YA 2WYMC 5ACXA 5K4NA 3LVZA 2GKLA 3VPEA 4BP0A 4FR7A 5B15A 3SRXA 2NXAA 2Q0JA 2I7TA 1XTOA 2FHXB 4H0DA 1WW1A 4KEPA 5B3RA 5DPXA 4TZEA 5K4MA 1YCFA 5LMCA 1X8HA 3S0ZA 2HB9A 2YNUA 5AJLA 2YNTB 4C1HA 5HH6A 1XM8A 4F6HA 4GYQA 4NQ5A 5IQKA 2BFZB 2Y8AA 4P62A 5HIPA 5FQCA 3X2ZA 5HH4A 2BGAA 3DHBA 2BFKA 3X2XA 2Y8BA 3ZR9A 4UA4A 4TZ9A 1VJNA 2P4ZA 3FAIA 4EYFA 4TZFA 5EVKA 2UYXA 5EVDA 2FU7A 4D1WA 5A87A 4HKYA 3R2UA 1P9EA 4AWZA 5LE1A 3BK1A 4Z7RA 3RKJA 4LE6A 5HIOA 1JT1A 2OHJA 4JO0A 4AV7A 4EXSA 3F9OA 2FU6A 2WHGA 3DH8A 4RAMA 4ZEJA 2BFLA 4GCWA 1DD6A 3ZNBA 4UBQA 2GMNA 4PDXA 1A8TA 5ACRA 3IDZA 1ZNBA 4RL0A 1A7TA 1X8GA 1X8IA 3IOFA 2QJSA 3KNRA 2ZO4A 4AWYB 4D02A 4KEQA 1BMCA 5LSCA 3DHAA 4RAWA 1DDKA 2VW8A 4C1EA 4WD6A 3SBLA 5LCHA 2Q0IA 5FQBA 4UWSB 2BIBA 5ACSA 2XF4A 3I11A 1ZTCA 5HISA 2YNWA 4NURA 1MQOA 1DXKA 3SW3A 4YSKA 5EV6A 5LM6A 3ZQ4A 2CFZA 3AJ3A 4B87A 5ACPA 3SD9A 4Z5ZA 3T3OA 4TYTA 2BG8B 2P1EA 4FEKA 5ACTA 2I7XA 1QH5A 4YSBA 3BK2A 4AX0B 5A0VA 3KNSA 2AIOA 1KO3A 3AF5A 4Z60A 1K07A 2YNVB 5B1UA 3ESHA 5EW0A 4AX1B 4EFZA 4ZO3A 4TYFA 2A7MA 1E5DA 3P2UA 4HL2A 5LCFA 2OHIA 2R2DA 2ZWRA 1YCHA 3TP9A 4ZNBA 4UWPB 4NQ2A 1JJEA 2FHXA 5LCAA 1HLKA 2ZZIA 3BC2A 4ZO2A 5EHTA 4Z67A 2H6AA 2BTNA 4NQ6A 4EYBA 4Z5YA 3IEKA 3ZWFA 2WRSA 2YNTA 3PY5A 3IOGA 3Q6VA 2WYLA 2BFZA 2FK6A 4HL1A 4PVOA 1SMLA 4J5FA 1WUPA 3X2YA 2M5CA 4NQ4A 2BR6A 5EH9A 3I13A 2DOOA 4C1DA 4EYLA 2NYPA 3IE0A 2GCUA 2AZ4A 4U4LA 2YCBA 2I7VA 2FM6A 5AEBA 4F6ZA 5ACQA 2GFJA 5A23A 2P97A 3RKKA 3SPUA 3A4YA 3KL7A 1KR3A 4BZ3A 2GFKA 4XWTA 2DKFA 2Y87A 3IELA 5HIQA 1WUOA 4RL2A 3ADRA 2Q42A 1M2XA 5ACUA 3G1PA 2CBNA 4PVTA 2QEDA 4D1VA 5EWAA 2QINA 3AF6A 5AXRA 5HH5A 4GYUA 3X30A 2BMIA 4XWWA 2YHEA 4TZBA 3JXPA 1ZKPA 2QDSA 1VGNA 2CFUA 4C1CA 2ZNBA 3I15A 3I0VA 3FCZA 4Z6XA 5ACVA 5K0WA 5A5ZA 5AHRA 4D1TA 2CG2A 4FSBA 4AD9A 3SFPA 4C09A 3MD7A 5LS3A 4EXYA 3QH8A
chains in the Genus database with same CATH topology
5EVBA 2WYMA 2NZFA 3IE2A 2FU9A 4V0HA 4RM5A 4DILA 5KIKA 4D1UA 1VMEA 2P18A 5AXOA 1QH3A 2FU8A 4J5HA 1WRAA 5K4KA 1JJTA 3IEMA 2OHHA 3WXCA 1BVTA 4RBSA 2BC2A 4XUKA 5FQAA 1KO2A 2QDTA 3RPCA 5AHOA 4YSLA 2M5DA 4UAMA 4C1GA 2Q9UA 3H3EA 5KILA 3DHCA 5LLDA 1BC2A 4DIKA 2BG8A 4UWOB 2BG7A 2BG2A 4O98A 5EV8A 2YNVA 2YZ3A 3BV6A 4UWRB 1YCGA 4C1FA 3IE1A 5A0TA 3PG4A 3T3NA 2E7YA 4EY2A 3L6NA 2NZEA 5ACWA 3VQZA 4CHLA 2XR1A 3PY6A 2BG6A 1Y44A 3I14A 3T9MA 5AYAA 1L9YA 2WYMC 5ACXA 5K4NA 3LVZA 2GKLA 3VPEA 4BP0A 4FR7A 5B15A 3SRXA 2NXAA 2Q0JA 2I7TA 1XTOA 2FHXB 4H0DA 1WW1A 4KEPA 5B3RA 5DPXA 4TZEA 5K4MA 1YCFA 5LMCA 1X8HA 3S0ZA 2HB9A 2YNUA 2YNTB 4C1HA 5HH6A 1XM8A 4F6HA 4GYQA 4NQ5A 5IQKA 2BFZB 2Y8AA 4P62A 5HIPA 5FQCA 3X2ZA 5HH4A 2BGAA 3DHBA 2BFKA 3X2XA 2Y8BA 3ZR9A 4UA4A 4TZ9A 1VJNA 2P4ZA 3FAIA 4EYFA 4TZFA 5EVKA 2UYXA 5EVDA 2FU7A 4D1WA 5A87A 4HKYA 3R2UA 1P9EA 4AWZA 5LE1A 3BK1A 4Z7RA 3RKJA 4LE6A 5HIOA 1JT1A 2OHJA 4JO0A 4EXSA 3F9OA 2FU6A 2WHGA 3DH8A 4RAMA 4ZEJA 2BFLA 4GCWA 1DD6A 4UBQA 3ZNBA 2GMNA 1A8TA 5ACRA 3IDZA 1ZNBA 4RL0A 1A7TA 1X8GA 1X8IA 3IOFA 2QJSA 3KNRA 2ZO4A 4AWYB 4D02A 4KEQA 1BMCA 5LSCA 3DHAA 4RAWA 1DDKA 2VW8A 4C1EA 4WD6A 3SBLA 5LCHA 2Q0IA 5FQBA 4UWSB 2BIBA 5ACSA 2XF4A 3I11A 1ZTCA 5HISA 2YNWA 1MQOA 1DXKA 3SW3A 4YSKA 5EV6A 5LM6A 3ZQ4A 3AJ3A 4B87A 5ACPA 3SD9A 4Z5ZA 3T3OA 4TYTA 2BG8B 2P1EA 4FEKA 5ACTA 2I7XA 1QH5A 4YSBA 3BK2A 4AX0B 5A0VA 3KNSA 2AIOA 1KO3A 3AF5A 4Z60A 1K07A 2YNVB 5B1UA 3ESHA 5EW0A 4AX1B 4EFZA 4ZO3A 4TYFA 2A7MA 1E5DA 3P2UA 4HL2A 5LCFA 2OHIA 2R2DA 2ZWRA 1YCHA 3TP9A 4ZNBA 4UWPB 4NQ2A 1JJEA 2FHXA 5LCAA 1HLKA 2ZZIA 3BC2A 4ZO2A 5EHTA 4Z67A 2H6AA 2BTNA 4NQ6A 4EYBA 4Z5YA 3IEKA 3ZWFA 2WRSA 2YNTA 3PY5A 3IOGA 3Q6VA 2WYLA 2BFZA 2FK6A 4HL1A 4PVOA 1SMLA 4J5FA 1WUPA 3X2YA 2M5CA 4NQ4A 2BR6A 5EH9A 3I13A 2DOOA 4C1DA 4EYLA 2NYPA 3IE0A 2GCUA 2AZ4A 4U4LA 2YCBA 2I7VA 2FM6A 5AEBA 4F6ZA 5ACQA 2GFJA 2P97A 3RKKA 3SPUA 3A4YA 3KL7A 1KR3A 4BZ3A 2GFKA 4XWTA 2DKFA 2Y87A 3IELA 5HIQA 1WUOA 4RL2A 3ADRA 2Q42A 1M2XA 5ACUA 3G1PA 2CBNA 4PVTA 2QEDA 4D1VA 5EWAA 2QINA 3AF6A 5AXRA 5HH5A 4GYUA 3X30A 2BMIA 4XWWA 4TZBA 3JXPA 1ZKPA 2QDSA 1VGNA 4C1CA 2ZNBA 3I15A 3I0VA 3FCZA 4Z6XA 5ACVA 5K0WA 5A5ZA 5AHRA 4D1TA 4FSBA 4AD9A 3SFPA 4C09A 3MD7A 5LS3A 4EXYA 3QH8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EVB A;  2WYM A;  2NZF A;  3IE2 A;  2FU9 A;  4V0H A;  4RM5 A;  4DIL A;  5KIK A;  4D1U A;  1VME A;  2P18 A;  5AXO A;  1QH3 A;  2FU8 A;  4J5H A;  1WRA A;  5K4K A;  1JJT A;  3IEM A;  2OHH A;  3WXC A;  1BVT A;  4RBS A;  2BC2 A;  4XUK A;  5FQA A;  1KO2 A;  2QDT A;  3RPC A;  5AHO A;  4YSL A;  2M5D A;  4UAM A;  4C1G A;  2Q9U A;  3H3E A;  5KIL A;  3DHC A;  5LLD A;  1BC2 A;  4DIK A;  2BG8 A;  4UWO B;  2BG7 A;  2BG2 A;  4O98 A;  5EV8 A;  2YNV A;  2YZ3 A;  3BV6 A;  4UWR B;  1YCG A;  4C1F A;  3IE1 A;  5A0T A;  3PG4 A;  3T3N A;  2E7Y A;  4EY2 A;  3L6N A;  2NZE A;  5ACW A;  3VQZ A;  4CHL A;  2XR1 A;  3PY6 A;  2BG6 A;  1Y44 A;  3I14 A;  3T9M A;  5AYA A;  1L9Y A;  2WYM C;  5ACX A;  5K4N A;  3LVZ A;  2GKL A;  3VPE A;  4BP0 A;  4FR7 A;  5B15 A;  3SRX A;  2NXA A;  2Q0J A;  2I7T A;  1XTO A;  2FHX B;  4H0D A;  1WW1 A;  4KEP A;  5B3R A;  5DPX A;  4TZE A;  5K4M A;  1YCF A;  5LMC A;  1X8H A;  3S0Z A;  2HB9 A;  2YNU A;  2YNT B;  4C1H A;  5HH6 A;  1XM8 A;  4F6H A;  4GYQ A;  4NQ5 A;  5IQK A;  2BFZ B;  2Y8A A;  4P62 A;  5HIP A;  5FQC A;  3X2Z A;  5HH4 A;  2BGA A;  3DHB A;  2BFK A;  3X2X A;  2Y8B A;  3ZR9 A;  4UA4 A;  4TZ9 A;  1VJN A;  2P4Z A;  3FAI A;  4EYF A;  4TZF A;  5EVK A;  2UYX A;  5EVD A;  2FU7 A;  4D1W A;  5A87 A;  4HKY A;  3R2U A;  1P9E A;  4AWZ A;  5LE1 A;  3BK1 A;  4Z7R A;  3RKJ A;  4LE6 A;  5HIO A;  1JT1 A;  2OHJ A;  4JO0 A;  4EXS A;  3F9O A;  2FU6 A;  2WHG A;  3DH8 A;  4RAM A;  4ZEJ A;  2BFL A;  4GCW A;  1DD6 A;  4UBQ A;  3ZNB A;  2GMN A;  1A8T A;  5ACR A;  3IDZ A;  1ZNB A;  4RL0 A;  1A7T A;  1X8G A;  1X8I A;  3IOF A;  2QJS A;  3KNR A;  2ZO4 A;  4AWY B;  4D02 A;  4KEQ A;  1BMC A;  5LSC A;  3DHA A;  4RAW A;  1DDK A;  2VW8 A;  4C1E A;  4WD6 A;  3SBL A;  5LCH A;  2Q0I A;  5FQB A;  4UWS B;  2BIB A;  5ACS A;  2XF4 A;  3I11 A;  1ZTC A;  5HIS A;  2YNW A;  1MQO A;  1DXK A;  3SW3 A;  4YSK A;  5EV6 A;  5LM6 A;  3ZQ4 A;  3AJ3 A;  4B87 A;  5ACP A;  3SD9 A;  4Z5Z A;  3T3O A;  4TYT A;  2BG8 B;  2P1E A;  4FEK A;  5ACT A;  2I7X A;  1QH5 A;  4YSB A;  3BK2 A;  4AX0 B;  5A0V A;  3KNS A;  2AIO A;  1KO3 A;  3AF5 A;  4Z60 A;  1K07 A;  2YNV B;  5B1U A;  3ESH A;  5EW0 A;  4AX1 B;  4EFZ A;  4ZO3 A;  4TYF A;  2A7M A;  1E5D A;  3P2U A;  4HL2 A;  5LCF A;  2OHI A;  2R2D A;  2ZWR A;  1YCH A;  3TP9 A;  4ZNB A;  4UWP B;  4NQ2 A;  1JJE A;  2FHX A;  5LCA A;  1HLK A;  2ZZI A;  3BC2 A;  4ZO2 A;  5EHT A;  4Z67 A;  2H6A A;  2BTN A;  4NQ6 A;  4EYB A;  4Z5Y A;  3IEK A;  3ZWF A;  2WRS A;  2YNT A;  3PY5 A;  3IOG A;  3Q6V A;  2WYL A;  2BFZ A;  2FK6 A;  4HL1 A;  4PVO A;  1SML A;  4J5F A;  1WUP A;  3X2Y A;  2M5C A;  4NQ4 A;  2BR6 A;  5EH9 A;  3I13 A;  2DOO A;  4C1D A;  4EYL A;  2NYP A;  3IE0 A;  2GCU A;  2AZ4 A;  4U4L A;  2YCB A;  2I7V A;  2FM6 A;  5AEB A;  4F6Z A;  5ACQ A;  2GFJ A;  2P97 A;  3RKK A;  3SPU A;  3A4Y A;  3KL7 A;  1KR3 A;  4BZ3 A;  2GFK A;  4XWT A;  2DKF A;  2Y87 A;  3IEL A;  5HIQ A;  1WUO A;  4RL2 A;  3ADR A;  2Q42 A;  1M2X A;  5ACU A;  3G1P A;  2CBN A;  4PVT A;  2QED A;  4D1V A;  5EWA A;  2QIN A;  3AF6 A;  5AXR A;  5HH5 A;  4GYU A;  3X30 A;  2BMI A;  4XWW A;  4TZB A;  3JXP A;  1ZKP A;  2QDS A;  1VGN A;  4C1C A;  2ZNB A;  3I15 A;  3I0V A;  3FCZ A;  4Z6X A;  5ACV A;  5K0W A;  5A5Z A;  5AHR A;  4D1T A;  4FSB A;  4AD9 A;  3SFP A;  4C09 A;  3MD7 A;  5LS3 A;  4EXY A;  3QH8 A; 
#chains in the Genus database with same CATH topology
 5EVB A;  2WYM A;  2CG3 A;  2NZF A;  3IE2 A;  2FU9 A;  4V0H A;  4RM5 A;  4DIL A;  5KIK A;  4D1U A;  1VME A;  2P18 A;  5AXO A;  1QH3 A;  2FU8 A;  4J5H A;  1WRA A;  5K4K A;  1JJT A;  3IEM A;  2OHH A;  3WXC A;  1BVT A;  4RBS A;  2BC2 A;  4XUK A;  5FQA A;  1KO2 A;  2QDT A;  3RPC A;  5AHO A;  4YSL A;  2M5D A;  5AIJ A;  4UAM A;  4C1G A;  2Q9U A;  3H3E A;  5KIL A;  3DHC A;  5LLD A;  1BC2 A;  4DIK A;  2BG8 A;  4UWO B;  2BG7 A;  2BG2 A;  4O98 A;  5EV8 A;  2YNV A;  2YZ3 A;  3BV6 A;  4UWR B;  1YCG A;  4C1F A;  3IE1 A;  5A0T A;  3PG4 A;  3T3N A;  2E7Y A;  4EY2 A;  3L6N A;  2NZE A;  5ACW A;  3VQZ A;  4CHL A;  2XR1 A;  3PY6 A;  2BG6 A;  1Y44 A;  4AXH A;  3I14 A;  3T9M A;  5AYA A;  1L9Y A;  2WYM C;  5ACX A;  5K4N A;  3LVZ A;  2GKL A;  3VPE A;  4BP0 A;  4FR7 A;  5B15 A;  3SRX A;  2NXA A;  2Q0J A;  2I7T A;  1XTO A;  2FHX B;  4H0D A;  1WW1 A;  4KEP A;  5B3R A;  5DPX A;  4TZE A;  5K4M A;  1YCF A;  5LMC A;  1X8H A;  3S0Z A;  2HB9 A;  2YNU A;  5AJL A;  2YNT B;  4C1H A;  5HH6 A;  1XM8 A;  4F6H A;  4GYQ A;  4NQ5 A;  5IQK A;  2BFZ B;  2Y8A A;  4P62 A;  5HIP A;  5FQC A;  3X2Z A;  5HH4 A;  2BGA A;  3DHB A;  2BFK A;  3X2X A;  2Y8B A;  3ZR9 A;  4UA4 A;  4TZ9 A;  1VJN A;  2P4Z A;  3FAI A;  4EYF A;  4TZF A;  5EVK A;  2UYX A;  5EVD A;  2FU7 A;  4D1W A;  5A87 A;  4HKY A;  3R2U A;  1P9E A;  4AWZ A;  5LE1 A;  3BK1 A;  4Z7R A;  3RKJ A;  4LE6 A;  5HIO A;  1JT1 A;  2OHJ A;  4JO0 A;  4AV7 A;  4EXS A;  3F9O A;  2FU6 A;  2WHG A;  3DH8 A;  4RAM A;  4ZEJ A;  2BFL A;  4GCW A;  1DD6 A;  3ZNB A;  4UBQ A;  2GMN A;  4PDX A;  1A8T A;  5ACR A;  3IDZ A;  1ZNB A;  4RL0 A;  1A7T A;  1X8G A;  1X8I A;  3IOF A;  2QJS A;  3KNR A;  2ZO4 A;  4AWY B;  4D02 A;  4KEQ A;  1BMC A;  5LSC A;  3DHA A;  4RAW A;  1DDK A;  2VW8 A;  4C1E A;  4WD6 A;  3SBL A;  5LCH A;  2Q0I A;  5FQB A;  4UWS B;  2BIB A;  5ACS A;  2XF4 A;  3I11 A;  1ZTC A;  5HIS A;  2YNW A;  4NUR A;  1MQO A;  1DXK A;  3SW3 A;  4YSK A;  5EV6 A;  5LM6 A;  3ZQ4 A;  2CFZ A;  3AJ3 A;  4B87 A;  5ACP A;  3SD9 A;  4Z5Z A;  3T3O A;  4TYT A;  2BG8 B;  2P1E A;  4FEK A;  5ACT A;  2I7X A;  1QH5 A;  4YSB A;  3BK2 A;  4AX0 B;  5A0V A;  3KNS A;  2AIO A;  1KO3 A;  3AF5 A;  4Z60 A;  1K07 A;  2YNV B;  5B1U A;  3ESH A;  5EW0 A;  4AX1 B;  4EFZ A;  4ZO3 A;  4TYF A;  2A7M A;  1E5D A;  3P2U A;  4HL2 A;  5LCF A;  2OHI A;  2R2D A;  2ZWR A;  1YCH A;  3TP9 A;  4ZNB A;  4UWP B;  4NQ2 A;  1JJE A;  2FHX A;  5LCA A;  1HLK A;  2ZZI A;  3BC2 A;  4ZO2 A;  5EHT A;  4Z67 A;  2H6A A;  2BTN A;  4NQ6 A;  4EYB A;  4Z5Y A;  3IEK A;  3ZWF A;  2WRS A;  2YNT A;  3PY5 A;  3IOG A;  3Q6V A;  2WYL A;  2BFZ A;  2FK6 A;  4HL1 A;  4PVO A;  1SML A;  4J5F A;  1WUP A;  3X2Y A;  2M5C A;  4NQ4 A;  2BR6 A;  5EH9 A;  3I13 A;  2DOO A;  4C1D A;  4EYL A;  2NYP A;  3IE0 A;  2GCU A;  2AZ4 A;  4U4L A;  2YCB A;  2I7V A;  2FM6 A;  5AEB A;  4F6Z A;  5ACQ A;  2GFJ A;  5A23 A;  2P97 A;  3RKK A;  3SPU A;  3A4Y A;  3KL7 A;  1KR3 A;  4BZ3 A;  2GFK A;  4XWT A;  2DKF A;  2Y87 A;  3IEL A;  5HIQ A;  1WUO A;  4RL2 A;  3ADR A;  2Q42 A;  1M2X A;  5ACU A;  3G1P A;  2CBN A;  4PVT A;  2QED A;  4D1V A;  5EWA A;  2QIN A;  3AF6 A;  5AXR A;  5HH5 A;  4GYU A;  3X30 A;  2BMI A;  4XWW A;  2YHE A;  4TZB A;  3JXP A;  1ZKP A;  2QDS A;  1VGN A;  2CFU A;  4C1C A;  2ZNB A;  3I15 A;  3I0V A;  3FCZ A;  4Z6X A;  5ACV A;  5K0W A;  5A5Z A;  5AHR A;  4D1T A;  2CG2 A;  4FSB A;  4AD9 A;  3SFP A;  4C09 A;  3MD7 A;  5LS3 A;  4EXY A;  3QH8 A; 
#chains in the Genus database with same CATH homology
 5EVB A;  2WYM A;  2NZF A;  3IE2 A;  2FU9 A;  4V0H A;  4RM5 A;  4DIL A;  5KIK A;  4D1U A;  1VME A;  2P18 A;  5AXO A;  1QH3 A;  2FU8 A;  4J5H A;  1WRA A;  5K4K A;  1JJT A;  3IEM A;  2OHH A;  3WXC A;  1BVT A;  4RBS A;  2BC2 A;  4XUK A;  5FQA A;  1KO2 A;  2QDT A;  3RPC A;  5AHO A;  4YSL A;  2M5D A;  4UAM A;  4C1G A;  2Q9U A;  3H3E A;  5KIL A;  3DHC A;  5LLD A;  1BC2 A;  4DIK A;  2BG8 A;  4UWO B;  2BG7 A;  2BG2 A;  4O98 A;  5EV8 A;  2YNV A;  2YZ3 A;  3BV6 A;  4UWR B;  1YCG A;  4C1F A;  3IE1 A;  5A0T A;  3PG4 A;  3T3N A;  2E7Y A;  4EY2 A;  3L6N A;  2NZE A;  5ACW A;  3VQZ A;  4CHL A;  2XR1 A;  3PY6 A;  2BG6 A;  1Y44 A;  3I14 A;  3T9M A;  5AYA A;  1L9Y A;  2WYM C;  5ACX A;  5K4N A;  3LVZ A;  2GKL A;  3VPE A;  4BP0 A;  4FR7 A;  5B15 A;  3SRX A;  2NXA A;  2Q0J A;  2I7T A;  1XTO A;  2FHX B;  4H0D A;  1WW1 A;  4KEP A;  5B3R A;  5DPX A;  4TZE A;  5K4M A;  1YCF A;  5LMC A;  1X8H A;  3S0Z A;  2HB9 A;  2YNU A;  2YNT B;  4C1H A;  5HH6 A;  1XM8 A;  4F6H A;  4GYQ A;  4NQ5 A;  5IQK A;  2BFZ B;  2Y8A A;  4P62 A;  5HIP A;  5FQC A;  3X2Z A;  5HH4 A;  2BGA A;  3DHB A;  2BFK A;  3X2X A;  2Y8B A;  3ZR9 A;  4UA4 A;  4TZ9 A;  1VJN A;  2P4Z A;  3FAI A;  4EYF A;  4TZF A;  5EVK A;  2UYX A;  5EVD A;  2FU7 A;  4D1W A;  5A87 A;  4HKY A;  3R2U A;  1P9E A;  4AWZ A;  5LE1 A;  3BK1 A;  4Z7R A;  3RKJ A;  4LE6 A;  5HIO A;  1JT1 A;  2OHJ A;  4JO0 A;  4EXS A;  3F9O A;  2FU6 A;  2WHG A;  3DH8 A;  4RAM A;  4ZEJ A;  2BFL A;  4GCW A;  1DD6 A;  4UBQ A;  3ZNB A;  2GMN A;  1A8T A;  5ACR A;  3IDZ A;  1ZNB A;  4RL0 A;  1A7T A;  1X8G A;  1X8I A;  3IOF A;  2QJS A;  3KNR A;  2ZO4 A;  4AWY B;  4D02 A;  4KEQ A;  1BMC A;  5LSC A;  3DHA A;  4RAW A;  1DDK A;  2VW8 A;  4C1E A;  4WD6 A;  3SBL A;  5LCH A;  2Q0I A;  5FQB A;  4UWS B;  2BIB A;  5ACS A;  2XF4 A;  3I11 A;  1ZTC A;  5HIS A;  2YNW A;  1MQO A;  1DXK A;  3SW3 A;  4YSK A;  5EV6 A;  5LM6 A;  3ZQ4 A;  3AJ3 A;  4B87 A;  5ACP A;  3SD9 A;  4Z5Z A;  3T3O A;  4TYT A;  2BG8 B;  2P1E A;  4FEK A;  5ACT A;  2I7X A;  1QH5 A;  4YSB A;  3BK2 A;  4AX0 B;  5A0V A;  3KNS A;  2AIO A;  1KO3 A;  3AF5 A;  4Z60 A;  1K07 A;  2YNV B;  5B1U A;  3ESH A;  5EW0 A;  4AX1 B;  4EFZ A;  4ZO3 A;  4TYF A;  2A7M A;  1E5D A;  3P2U A;  4HL2 A;  5LCF A;  2OHI A;  2R2D A;  2ZWR A;  1YCH A;  3TP9 A;  4ZNB A;  4UWP B;  4NQ2 A;  1JJE A;  2FHX A;  5LCA A;  1HLK A;  2ZZI A;  3BC2 A;  4ZO2 A;  5EHT A;  4Z67 A;  2H6A A;  2BTN A;  4NQ6 A;  4EYB A;  4Z5Y A;  3IEK A;  3ZWF A;  2WRS A;  2YNT A;  3PY5 A;  3IOG A;  3Q6V A;  2WYL A;  2BFZ A;  2FK6 A;  4HL1 A;  4PVO A;  1SML A;  4J5F A;  1WUP A;  3X2Y A;  2M5C A;  4NQ4 A;  2BR6 A;  5EH9 A;  3I13 A;  2DOO A;  4C1D A;  4EYL A;  2NYP A;  3IE0 A;  2GCU A;  2AZ4 A;  4U4L A;  2YCB A;  2I7V A;  2FM6 A;  5AEB A;  4F6Z A;  5ACQ A;  2GFJ A;  2P97 A;  3RKK A;  3SPU A;  3A4Y A;  3KL7 A;  1KR3 A;  4BZ3 A;  2GFK A;  4XWT A;  2DKF A;  2Y87 A;  3IEL A;  5HIQ A;  1WUO A;  4RL2 A;  3ADR A;  2Q42 A;  1M2X A;  5ACU A;  3G1P A;  2CBN A;  4PVT A;  2QED A;  4D1V A;  5EWA A;  2QIN A;  3AF6 A;  5AXR A;  5HH5 A;  4GYU A;  3X30 A;  2BMI A;  4XWW A;  4TZB A;  3JXP A;  1ZKP A;  2QDS A;  1VGN A;  4C1C A;  2ZNB A;  3I15 A;  3I0V A;  3FCZ A;  4Z6X A;  5ACV A;  5K0W A;  5A5Z A;  5AHR A;  4D1T A;  4FSB A;  4AD9 A;  3SFP A;  4C09 A;  3MD7 A;  5LS3 A;  4EXY A;  3QH8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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