1K90A

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 3' deoxy-atp
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
507
structure length
485
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords CALMODULIN-SENSITIVE ADENYLATE CYCLASE
publication title Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
pubmed doi rcsb
source organism Bacillus anthracis
molecule tags Toxin,lyase/metal binding protein
total genus 135
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2001-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1k90A03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1k90A02
2COLA 1ZOTA 1XFXA 1YRTA 1LVCA 1K93A 1SK6A 1PK0A 1Y0VA 1XFUA 1K90A 1XFVA 1YRUA 1XFZA 1XFWA 1K8TA 1S26A 1XFYA
chains in the Genus database with same CATH superfamily
3D9DA 4L1FA 3Q23A 2E80A 1RX0A 2BU8A 1SK6A 2Z1QA 3C2PA 1XFUA 2RF7A 4O5MA 1XFZA 3OWMA 4ZXVA 1PI1A 2EBHX 2EBFX 3MXLA 4MPEA 5BRMA 3P4TA 2VF1A 2IX6A 4MPCA 1QDBA 3D9FA 4G97A 4Q5CA 1ZOTA 4HKSA 4DOYA 1Y8NA 2BU2A 3C3LA 3LG1A 2R0MA 3VKHA 2QR4A 2XS8A 2ZKJA 2R0NA 2AO2A 2R03A 5K3HA 5GJVE 2J7AA 3D6BA 2XS1A 2F6LA 2LFWA 1SIRA 4F0XA 1X91A 1EGCA 2PG0A 2UXWA 3FCJA 4AKHA 3Q22A 1EGEA 2BU7A 2BU6A 4Q5BA 1XFXA 2DVLA 3D2RA 3GNCA 5GJWE 1LVCA 4Q17A 4WJYA 5B5WA 2OJQA 2YYGA 3NF4A 3MDDA 2PO4A 3B96A 4JEKA 1R2JA 2OEVA 4QICA 3X0YA 1UKWA 5M4MA 1WS9A 2OR0A 1IS2A 2DDHA 1XFVA 3CE2A 2CJ6A 1GKXA 1BUCA 1U8VA 2YYKA 4P13A 4HKRA 1XFYA 4JIOA 3CRKA 1JM6A 1Y8OA 4LQSB 1JQIA 4E00A 1YRTA 3OWAA 1PK0A 1Y0VA 3VADA 5M4KA 5B6BA 4JIZA 4MPNA 4FF4A 4H85A 4L38A 4L3ZA 4N5FA 1FS9A 3SXQA 5BRKA 1SC5A 5J6AA 4MP7A 3TZ5A 1XG2B 2R05A 2R02A 3M9VA 2JBRA 2Q8IA 5M4NA 4AKIA 2Q8FA 1RJ1A 3MDEA 4FF2A 1S26A 3EOMA 2E0AA 4NXLA 4G5EA 4AI6A 1GJVA 4J1VA 4MP2A 3BNJA 3TZ0A 3MMOA 3TZ4A 2VIGA 1K90A 2D29A 4E01A 3UBRA 2CJ5A 3MKHA 3PFDA 1Y8PA 3CRLA 4HR3A 5J71A 3AFFA 2C0UA 2YYLA 4FF3A 3GM6A 2A1TA 3F29A 1GU6A 1RJ4A 3TORA 2YYIA 3X29A 4E02A 1XFWA 1K8TA 1SIQA 2WBIA 2COLA 3BNHA 2RFQA 2ZAFA 1UDYA 2YYMA 1R3BA 2GBBA 4Q0TA 5B5VA 4V26A 3C46A 3LGQA 4H81A 3HWCA 1FS7A 1X90A 2CJ4A 4AKGA 3D9EA 4KSAA 2VR0A 5K3IA 2CJ7A 3VKGA 2BU5A 2CJ8A 1EGDA 2FP2A 4V25A 4FF1A 4IRNA 3GQTA 4H7QA 4X28C 1W07A 5K3GA 5M4PA 2FONA 2XQRB 3MPJA 4L3YA 2AZEA 4FZ4A 3TTBA 3X0XA 3SCEA 4U83A 2EBAA 3BNFA 2OT4A 3OIBA 1OAHA 1X8ZA 3MPIA 1T9GA 3D1IA 4IV6A 4X28A 2ZO5A 5K3JA 4DZYA 2REHA 2JBSA 3FO3A 3R7KA 4KTOA 4W9UA 2CX9A 3D9GA 1FS8A 2JBTA 4LQQB 4OO2A 2YGWA 3S7WA 4ZYJA 1YRUA 2ZDXA 4L3XA 2JIFA 4XVXA 2YYJA 3N0RA 4M9AA 3UU9A 3L1TA 1GKZA 2FP1A 3AFEA 4Q1OA 2PNRA 1IVHA 2BTZA 4KS9A 2IX5A 3EONA 2Q8HA 3SF6A 3Q24A 3Q0AA 3SWOA 2E81A 2OEXA 2C12A 3BNGA 4KCFA 2ZDYA 4KSFA 2EC5A 2Q8GA 3RKHA 3II9A 1K93A 3TZ2A 2RDZA 4RM7A 2HJNA 4P79A 4Q4UA 3KMLA 1RP3A
chains in the Genus database with same CATH topology
3Q23A 4FF3A 3C2PA 1SK6A 1XFUA 1XFVA 3CE2A 1XFZA 3X29A 1XFWA 1K8TA 2EBHX 2EBFX 4HKRA 2COLA 1XFYA 2VF1A 4G97A 1ZOTA 4HKSA 2YGWA 1YRTA 1PK0A 1Y0VA 2GBBA 3C46A 3C3LA 4FF4A 1YRUA 3VKHA 3N0RA 2QR4A 2AO2A 2FP1A 1SC5A 4AKGA 5GJVE 4KS9A 3Q24A 4KSAA 2F6LA 3VKGA 2LFWA 3Q0AA 4F0XA 4AKIA 4FF2A 1S26A 2FP2A 4AKHA 3Q22A 4FF1A 4AI6A 4KSFA 2EC5A 1XFXA 5GJWE 1LVCA 1K93A 1K90A 2AZEA 4FZ4A 2PO4A 4P79A 4QICA 3KMLA 1RP3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2COL A;  1ZOT A;  1XFX A;  1YRT A;  1LVC A;  1K93 A;  1SK6 A;  1PK0 A;  1Y0V A;  1XFU A;  1K90 A;  1XFV A;  1YRU A;  1XFZ A;  1XFW A;  1K8T A;  1S26 A;  1XFY A; 
#chains in the Genus database with same CATH topology
 3D9D A;  4L1F A;  3Q23 A;  2E80 A;  1RX0 A;  2BU8 A;  1SK6 A;  2Z1Q A;  3C2P A;  1XFU A;  2RF7 A;  4O5M A;  1XFZ A;  3OWM A;  4ZXV A;  1PI1 A;  2EBH X;  2EBF X;  3MXL A;  4MPE A;  5BRM A;  3P4T A;  2VF1 A;  2IX6 A;  4MPC A;  1QDB A;  3D9F A;  4G97 A;  4Q5C A;  1ZOT A;  4HKS A;  4DOY A;  1Y8N A;  2BU2 A;  3C3L A;  3LG1 A;  2R0M A;  3VKH A;  2QR4 A;  2XS8 A;  2ZKJ A;  2R0N A;  2AO2 A;  2R03 A;  5K3H A;  5GJV E;  2J7A A;  3D6B A;  2XS1 A;  2F6L A;  2LFW A;  1SIR A;  4F0X A;  1X91 A;  1EGC A;  2PG0 A;  2UXW A;  3FCJ A;  4AKH A;  3Q22 A;  1EGE A;  2BU7 A;  2BU6 A;  4Q5B A;  1XFX A;  2DVL A;  3D2R A;  3GNC A;  5GJW E;  1LVC A;  4Q17 A;  4WJY A;  5B5W A;  2OJQ A;  2YYG A;  3NF4 A;  3MDD A;  2PO4 A;  3B96 A;  4JEK A;  1R2J A;  2OEV A;  4QIC A;  3X0Y A;  1UKW A;  5M4M A;  1WS9 A;  2OR0 A;  1IS2 A;  2DDH A;  1XFV A;  3CE2 A;  2CJ6 A;  1GKX A;  1BUC A;  1U8V A;  2YYK A;  4P13 A;  4HKR A;  1XFY A;  4JIO A;  3CRK A;  1JM6 A;  1Y8O A;  4LQS B;  1JQI A;  4E00 A;  1YRT A;  3OWA A;  1PK0 A;  1Y0V A;  3VAD A;  5M4K A;  5B6B A;  4JIZ A;  4MPN A;  4FF4 A;  4H85 A;  4L38 A;  4L3Z A;  4N5F A;  1FS9 A;  3SXQ A;  5BRK A;  1SC5 A;  5J6A A;  4MP7 A;  3TZ5 A;  1XG2 B;  2R05 A;  2R02 A;  3M9V A;  2JBR A;  2Q8I A;  5M4N A;  4AKI A;  2Q8F A;  1RJ1 A;  3MDE A;  4FF2 A;  1S26 A;  3EOM A;  2E0A A;  4NXL A;  4G5E A;  4AI6 A;  1GJV A;  4J1V A;  4MP2 A;  3BNJ A;  3TZ0 A;  3MMO A;  3TZ4 A;  2VIG A;  1K90 A;  2D29 A;  4E01 A;  3UBR A;  2CJ5 A;  3MKH A;  3PFD A;  1Y8P A;  3CRL A;  4HR3 A;  5J71 A;  3AFF A;  2C0U A;  2YYL A;  4FF3 A;  3GM6 A;  2A1T A;  3F29 A;  1GU6 A;  1RJ4 A;  3TOR A;  2YYI A;  3X29 A;  4E02 A;  1XFW A;  1K8T A;  1SIQ A;  2WBI A;  2COL A;  3BNH A;  2RFQ A;  2ZAF A;  1UDY A;  2YYM A;  1R3B A;  2GBB A;  4Q0T A;  5B5V A;  4V26 A;  3C46 A;  3LGQ A;  4H81 A;  3HWC A;  1FS7 A;  1X90 A;  2CJ4 A;  4AKG A;  3D9E A;  4KSA A;  2VR0 A;  5K3I A;  2CJ7 A;  3VKG A;  2BU5 A;  2CJ8 A;  1EGD A;  2FP2 A;  4V25 A;  4FF1 A;  4IRN A;  3GQT A;  4H7Q A;  4X28 C;  1W07 A;  5K3G A;  5M4P A;  2FON A;  2XQR B;  3MPJ A;  4L3Y A;  2AZE A;  4FZ4 A;  3TTB A;  3X0X A;  3SCE A;  4U83 A;  2EBA A;  3BNF A;  2OT4 A;  3OIB A;  1OAH A;  1X8Z A;  3MPI A;  1T9G A;  3D1I A;  4IV6 A;  4X28 A;  2ZO5 A;  5K3J A;  4DZY A;  2REH A;  2JBS A;  3FO3 A;  3R7K A;  4KTO A;  4W9U A;  2CX9 A;  3D9G A;  1FS8 A;  2JBT A;  4LQQ B;  4OO2 A;  2YGW A;  3S7W A;  4ZYJ A;  1YRU A;  2ZDX A;  4L3X A;  2JIF A;  4XVX A;  2YYJ A;  3N0R A;  4M9A A;  3UU9 A;  3L1T A;  1GKZ A;  2FP1 A;  3AFE A;  4Q1O A;  2PNR A;  1IVH A;  2BTZ A;  4KS9 A;  2IX5 A;  3EON A;  2Q8H A;  3SF6 A;  3Q24 A;  3Q0A A;  3SWO A;  2E81 A;  2OEX A;  2C12 A;  3BNG A;  4KCF A;  2ZDY A;  4KSF A;  2EC5 A;  2Q8G A;  3RKH A;  3II9 A;  1K93 A;  3TZ2 A;  2RDZ A;  4RM7 A;  2HJN A;  4P79 A;  4Q4U A;  3KML A;  1RP3 A; 
#chains in the Genus database with same CATH homology
 3Q23 A;  4FF3 A;  3C2P A;  1SK6 A;  1XFU A;  1XFV A;  3CE2 A;  1XFZ A;  3X29 A;  1XFW A;  1K8T A;  2EBH X;  2EBF X;  4HKR A;  2COL A;  1XFY A;  2VF1 A;  4G97 A;  1ZOT A;  4HKS A;  2YGW A;  1YRT A;  1PK0 A;  1Y0V A;  2GBB A;  3C46 A;  3C3L A;  4FF4 A;  1YRU A;  3VKH A;  3N0R A;  2QR4 A;  2AO2 A;  2FP1 A;  1SC5 A;  4AKG A;  5GJV E;  4KS9 A;  3Q24 A;  4KSA A;  2F6L A;  3VKG A;  2LFW A;  3Q0A A;  4F0X A;  4AKI A;  4FF2 A;  1S26 A;  2FP2 A;  4AKH A;  3Q22 A;  4FF1 A;  4AI6 A;  4KSF A;  2EC5 A;  1XFX A;  5GJW E;  1LVC A;  1K93 A;  1K90 A;  2AZE A;  4FZ4 A;  2PO4 A;  4P79 A;  4QIC A;  3KML A;  1RP3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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