1K90A

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 3' deoxy-atp
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
507
structure length
485
Chain Sequence
b'RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords CALMODULIN-SENSITIVE ADENYLATE CYCLASE
publication title Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
pubmed doi rcsb
source organism Bacillus anthracis
molecule tags Toxin,lyase/metal binding protein
total genus 135
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2001-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1k90A03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1k90A02
1XFZA 1YRUA 1K90A 1PK0A 1XFYA 1ZOTA 1S26A 1SK6A 1XFXA 1K8TA 1XFWA 1XFVA 2COLA 1YRTA 1XFUA 1LVCA 1K93A 1Y0VA
chains in the Genus database with same CATH superfamily
2R05A 4P79A 2D29A 2YGWA 4G97A 2R0MA 3L1TA 1XFWA 2VIGA 3KMLA 1BUCA 3SWOA 2Q8IA 2C0UA 4N5FA 1YRUA 1EGCA 3MPJA 4J1VA 3LGQA 4KS9A 3LG1A 4E01A 4F0XA 5BRKA 3C2PA 4AKGA 3SXQA 2YYJA 3TZ5A 1RP3A 2ZDXA 2YYIA 2CJ8A 2ZAFA 4FF4A 2EBFX 1K8TA 2A1TA 3TORA 3R7KA 2FP2A 2YYLA 3VKHA 2COLA 4NXLA 2OEVA 2OJQA 3EONA 3P4TA 1X90A 4JIOA 3NF4A 4Q1OA 3MKHA 5GJVE 3D9DA 3C46A 2JIFA 2J7AA 2ZDYA 4KCFA 1SIRA 2BU8A 2VR0A 2XQRB 3BNFA 5J6AA 3FCJA 1X8ZA 4IV6A 1GKXA 4AKHA 5M4KA 4LQQB 4QICA 4L3ZA 1SK6A 2OR0A 3CE2A 4P13A 4WJYA 1LVCA 1IVHA 1RJ4A 2BU7A 2DVLA 4H7QA 5M4NA 3VKGA 4G5EA 3C3LA 1ZOTA 1QDBA 5K3GA 2E80A 2UXWA 2XS8A 3BNJA 3MPIA 4HKRA 2EBAA 2RF7A 2EBHX 4OO2A 4DZYA 1Y8PA 2CJ5A 1K93A 1JQIA 2FP1A 3F29A 1GJVA 3OIBA 4MPEA 4ZYJA 3MDDA 1GKZA 4E02A 3TZ4A 1FS9A 3UBRA 3UU9A 5B5VA 4DOYA 4RM7A 2BTZA 2FONA 3N0RA 3PFDA 3RKHA 1SC5A 2R0NA 4V26A 1GU6A 2BU6A 2EC5A 2CJ6A 4H81A 2PG0A 2YYKA 4Q5CA 2Q8FA 5K3HA 1UDYA 2AZEA 3GNCA 4KSAA 1R3BA 3OWMA 2VF1A 2E81A 3SF6A 1Y8OA 1WS9A 2IX5A 2R02A 3Q0AA 1XFYA 3AFEA 3B96A 4L3YA 3MMOA 4L3XA 1YRTA 3CRLA 4H85A 4FF3A 1XFUA 2QR4A 3AFFA 2JBTA 3FO3A 1Y8NA 1S26A 4X28A 1UKWA 4HR3A 3Q23A 2CJ7A 4O5MA 3TZ0A 3SCEA 4XVXA 3D1IA 2E0AA 4AKIA 2YYMA 3II9A 1XFZA 2CJ4A 2ZO5A 3TTBA 1XG2B 2IX6A 1XFXA 2PNRA 3BNHA 4KSFA 3Q22A 2HJNA 4L38A 3D2RA 4Q5BA 3S7WA 3GM6A 3TZ2A 5B5WA 4AI6A 1PK0A 4V25A 2BU5A 3X0XA 3X0YA 4JIZA 1RX0A 4ZXVA 1FS8A 2PO4A 3D6BA 3X29A 5J71A 2BU2A 4FZ4A 3D9FA 1R2JA 1T9GA 3EOMA 1JM6A 3D9EA 2RDZA 4MPCA 4Q4UA 2WBIA 2Q8GA 2XS1A 2OEXA 1PI1A 1XFVA 3OWAA 4MP2A 4FF2A 2AO2A 4E00A 3Q24A 1SIQA 1W07A 3CRKA 5M4PA 1FS7A 2LFWA 3HWCA 4Q17A 2F6LA 2C12A 2Q8HA 1IS2A 2OT4A 3BNGA 3M9VA 1Y0VA 3GQTA 2GBBA 1EGDA 3MDEA 4LQSB 1K90A 2RFQA 1X91A 3D9GA 2DDHA 5GJWE 4X28C 1U8VA 4L1FA 4IRNA 3MXLA 2REHA 4HKSA 5K3IA 1RJ1A 4FF1A 2Z1QA 2JBRA 2ZKJA 5K3JA 4JEKA 2JBSA 4Q0TA 1OAHA 2YYGA 4KTOA 4M9AA 4U83A 2R03A 4W9UA 1EGEA 5BRMA 5B6BA 4MPNA 5M4MA 2CX9A 3VADA 4MP7A
chains in the Genus database with same CATH topology
4P79A 4AKHA 4QICA 1XFYA 2YGWA 4G97A 1SK6A 3CE2A 1XFWA 1XFVA 4FF2A 1YRTA 3KMLA 4FF3A 2AO2A 1XFUA 1LVCA 2QR4A 3Q24A 3VKGA 1YRUA 2LFWA 4KS9A 3C2PA 2F6LA 3C3LA 1S26A 4F0XA 4AKGA 1ZOTA 4HKRA 3Q23A 2EBHX 4AKIA 2FP1A 1K93A 1Y0VA 2GBBA 1RP3A 1XFZA 1K90A 5GJWE 1XFXA 2EBFX 1K8TA 4FF4A 3VKHA 2FP2A 4HKSA 4KSFA 3Q22A 2COLA 4FF1A 3N0RA 3C46A 4AI6A 1SC5A 1PK0A 5GJVE 2EC5A 3Q0AA 3X29A 2PO4A 4FZ4A 2AZEA 4KSAA 2VF1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XFZ A;  1YRU A;  1K90 A;  1PK0 A;  1XFY A;  1ZOT A;  1S26 A;  1SK6 A;  1XFX A;  1K8T A;  1XFW A;  1XFV A;  2COL A;  1YRT A;  1XFU A;  1LVC A;  1K93 A;  1Y0V A; 
#chains in the Genus database with same CATH topology
 2R05 A;  4P79 A;  2D29 A;  2YGW A;  4G97 A;  2R0M A;  3L1T A;  1XFW A;  2VIG A;  3KML A;  1BUC A;  3SWO A;  2Q8I A;  2C0U A;  4N5F A;  1YRU A;  1EGC A;  3MPJ A;  4J1V A;  3LGQ A;  4KS9 A;  3LG1 A;  4E01 A;  4F0X A;  5BRK A;  3C2P A;  4AKG A;  3SXQ A;  2YYJ A;  3TZ5 A;  1RP3 A;  2ZDX A;  2YYI A;  2CJ8 A;  2ZAF A;  4FF4 A;  2EBF X;  1K8T A;  2A1T A;  3TOR A;  3R7K A;  2FP2 A;  2YYL A;  3VKH A;  2COL A;  4NXL A;  2OEV A;  2OJQ A;  3EON A;  3P4T A;  1X90 A;  4JIO A;  3NF4 A;  4Q1O A;  3MKH A;  5GJV E;  3D9D A;  3C46 A;  2JIF A;  2J7A A;  2ZDY A;  4KCF A;  1SIR A;  2BU8 A;  2VR0 A;  2XQR B;  3BNF A;  5J6A A;  3FCJ A;  1X8Z A;  4IV6 A;  1GKX A;  4AKH A;  5M4K A;  4LQQ B;  4QIC A;  4L3Z A;  1SK6 A;  2OR0 A;  3CE2 A;  4P13 A;  4WJY A;  1LVC A;  1IVH A;  1RJ4 A;  2BU7 A;  2DVL A;  4H7Q A;  5M4N A;  3VKG A;  4G5E A;  3C3L A;  1ZOT A;  1QDB A;  5K3G A;  2E80 A;  2UXW A;  2XS8 A;  3BNJ A;  3MPI A;  4HKR A;  2EBA A;  2RF7 A;  2EBH X;  4OO2 A;  4DZY A;  1Y8P A;  2CJ5 A;  1K93 A;  1JQI A;  2FP1 A;  3F29 A;  1GJV A;  3OIB A;  4MPE A;  4ZYJ A;  3MDD A;  1GKZ A;  4E02 A;  3TZ4 A;  1FS9 A;  3UBR A;  3UU9 A;  5B5V A;  4DOY A;  4RM7 A;  2BTZ A;  2FON A;  3N0R A;  3PFD A;  3RKH A;  1SC5 A;  2R0N A;  4V26 A;  1GU6 A;  2BU6 A;  2EC5 A;  2CJ6 A;  4H81 A;  2PG0 A;  2YYK A;  4Q5C A;  2Q8F A;  5K3H A;  1UDY A;  2AZE A;  3GNC A;  4KSA A;  1R3B A;  3OWM A;  2VF1 A;  2E81 A;  3SF6 A;  1Y8O A;  1WS9 A;  2IX5 A;  2R02 A;  3Q0A A;  1XFY A;  3AFE A;  3B96 A;  4L3Y A;  3MMO A;  4L3X A;  1YRT A;  3CRL A;  4H85 A;  4FF3 A;  1XFU A;  2QR4 A;  3AFF A;  2JBT A;  3FO3 A;  1Y8N A;  1S26 A;  4X28 A;  1UKW A;  4HR3 A;  3Q23 A;  2CJ7 A;  4O5M A;  3TZ0 A;  3SCE A;  4XVX A;  3D1I A;  2E0A A;  4AKI A;  2YYM A;  3II9 A;  1XFZ A;  2CJ4 A;  2ZO5 A;  3TTB A;  1XG2 B;  2IX6 A;  1XFX A;  2PNR A;  3BNH A;  4KSF A;  3Q22 A;  2HJN A;  4L38 A;  3D2R A;  4Q5B A;  3S7W A;  3GM6 A;  3TZ2 A;  5B5W A;  4AI6 A;  1PK0 A;  4V25 A;  2BU5 A;  3X0X A;  3X0Y A;  4JIZ A;  1RX0 A;  4ZXV A;  1FS8 A;  2PO4 A;  3D6B A;  3X29 A;  5J71 A;  2BU2 A;  4FZ4 A;  3D9F A;  1R2J A;  1T9G A;  3EOM A;  1JM6 A;  3D9E A;  2RDZ A;  4MPC A;  4Q4U A;  2WBI A;  2Q8G A;  2XS1 A;  2OEX A;  1PI1 A;  1XFV A;  3OWA A;  4MP2 A;  4FF2 A;  2AO2 A;  4E00 A;  3Q24 A;  1SIQ A;  1W07 A;  3CRK A;  5M4P A;  1FS7 A;  2LFW A;  3HWC A;  4Q17 A;  2F6L A;  2C12 A;  2Q8H A;  1IS2 A;  2OT4 A;  3BNG A;  3M9V A;  1Y0V A;  3GQT A;  2GBB A;  1EGD A;  3MDE A;  4LQS B;  1K90 A;  2RFQ A;  1X91 A;  3D9G A;  2DDH A;  5GJW E;  4X28 C;  1U8V A;  4L1F A;  4IRN A;  3MXL A;  2REH A;  4HKS A;  5K3I A;  1RJ1 A;  4FF1 A;  2Z1Q A;  2JBR A;  2ZKJ A;  5K3J A;  4JEK A;  2JBS A;  4Q0T A;  1OAH A;  2YYG A;  4KTO A;  4M9A A;  4U83 A;  2R03 A;  4W9U A;  1EGE A;  5BRM A;  5B6B A;  4MPN A;  5M4M A;  2CX9 A;  3VAD A;  4MP7 A; 
#chains in the Genus database with same CATH homology
 4P79 A;  4AKH A;  4QIC A;  1XFY A;  2YGW A;  4G97 A;  1SK6 A;  3CE2 A;  1XFW A;  1XFV A;  4FF2 A;  1YRT A;  3KML A;  4FF3 A;  2AO2 A;  1XFU A;  1LVC A;  2QR4 A;  3Q24 A;  3VKG A;  1YRU A;  2LFW A;  4KS9 A;  3C2P A;  2F6L A;  3C3L A;  1S26 A;  4F0X A;  4AKG A;  1ZOT A;  4HKR A;  3Q23 A;  2EBH X;  4AKI A;  2FP1 A;  1K93 A;  1Y0V A;  2GBB A;  1RP3 A;  1XFZ A;  1K90 A;  5GJW E;  1XFX A;  2EBF X;  1K8T A;  4FF4 A;  3VKH A;  2FP2 A;  4HKS A;  4KSF A;  3Q22 A;  2COL A;  4FF1 A;  3N0R A;  3C46 A;  4AI6 A;  1SC5 A;  1PK0 A;  5GJV E;  2EC5 A;  3Q0A A;  3X29 A;  2PO4 A;  4FZ4 A;  2AZE A;  4KSA A;  2VF1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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