1K90A

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 3' deoxy-atp
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
507
structure length
485
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin,lyase/metal binding protein
molecule keywords CALMODULIN-SENSITIVE ADENYLATE CYCLASE
publication title Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
pubmed doi rcsb
source organism Bacillus anthracis
total genus 135
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2001-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1k90A03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1k90A02
2COLA 1YRUA 1XFWA 1XFUA 1LVCA 1K93A 1XFZA 1SK6A 1XFYA 1S26A 1K90A 1K8TA 1XFXA 1Y0VA 1YRTA 1ZOTA 1XFVA 1PK0A
chains in the Genus database with same CATH superfamily
2Q8FA 4FF2A 3OWMA 2RF7A 3M9VA 3OIBA 2PG0A 5M4MA 4HKRA 2AZEA 2BU6A 2EC5A 2OEXA 2RDZA 5J6AA 1R2JA 2YYIA 3X0YA 3C46A 3SCEA 1JQIA 3SWOA 1XFZA 2E81A 2WBIA 3CE2A 3UBRA 3Q23A 5B5VA 2ZDXA 2Q8HA 4L3ZA 1R3BA 1Y8PA 3MDDA 4L3YA 4MPNA 4Q17A 4W9UA 4WJYA 3N0RA 5J71A 5B6BA 5K3IA 4KSAA 2YYMA 4H7QA 4FF1A 3RKHA 1XFXA 5K3HA 3C3LA 1W07A 3TZ2A 3SF6A 3BNHA 2R03A 3MPIA 4JIZA 2BU8A 4KSFA 2JBSA 3LGQA 1YRTA 2BU7A 2PO4A 4KCFA 1FS9A 3FO3A 2CJ5A 4HKSA 2VF1A 4AKIA 5M4PA 3D6BA 2JIFA 2EBHX 3TZ5A 2R0MA 3X0XA 1XFYA 2IX5A 2ZO5A 4JIOA 4P79A 4IV6A 2FP2A 1EGEA 2OJQA 1RJ4A 3X29A 2QR4A 2VIGA 2C12A 3OWAA 4V25A 5GJWE 4F0XA 4MP7A 2ZAFA 3TZ4A 2OT4A 3Q24A 3MMOA 2J7AA 1EGDA 3B96A 2XS1A 2E0AA 1T9GA 3BNGA 1EGCA 2BU2A 4IRNA 2FONA 3GM6A 3C2PA 1GKZA 3D9FA 4FF4A 2BU5A 1FS7A 2FP1A 2LFWA 4RM7A 4ZXVA 4AKHA 3D9DA 4O5MA 3BNFA 2Q8IA 1SK6A 2ZDYA 3L1TA 3S7WA 4V26A 3VADA 1GJVA 1IS2A 1GU6A 2EBAA 3GNCA 4Q1OA 3SXQA 1SIQA 4E00A 2F6LA 3AFFA 1QDBA 2JBTA 1X8ZA 2YYJA 2Z1QA 4E02A 1GKXA 4ZYJA 1U8VA 3VKGA 1Y8OA 3MXLA 4J1VA 4LQSB 3LG1A 5B5WA 3NF4A 1XFVA 2E80A 2XS8A 4Q0TA 2UXWA 4G5EA 3II9A 4OO2A 3Q22A 2CJ8A 3D2RA 2OR0A 4G97A 3CRLA 4Q4UA 1ZOTA 4M9AA 4X28A 3VKHA 2VR0A 4L38A 3TORA 2D29A 3MDEA 4NXLA 2AO2A 5M4KA 3MKHA 4KS9A 2BTZA 2YYLA 4HR3A 4MPCA 4MPEA 2Q8GA 1K90A 1SIRA 4MP2A 4L1FA 3P4TA 5GJVE 1IVHA 1WS9A 1X91A 1Y8NA 2IX6A 2R02A 4XVXA 1RP3A 1SC5A 1XFWA 2XQRB 2ZKJA 5BRMA 1XFUA 3GQTA 4H85A 4Q5BA 4Q5CA 2CJ7A 2RFQA 4AI6A 1BUCA 3EONA 1JM6A 1UDYA 2YGWA 4DZYA 3PFDA 4P13A 1RJ1A 1FS8A 4FF3A 2EBFX 2CX9A 4JEKA 2GBBA 4DOYA 3UU9A 1K8TA 3MPJA 3FCJA 1UKWA 2DVLA 3HWCA 4QICA 3KMLA 2YYKA 2HJNA 1PI1A 5K3GA 3BNJA 1YRUA 4U83A 3D1IA 3Q0AA 2CJ6A 1LVCA 3D9GA 1K93A 1Y0VA 2DDHA 1XG2B 2R0NA 3D9EA 2C0UA 4LQQB 5K3JA 3CRKA 3EOMA 2REHA 3TTBA 2YYGA 4E01A 3R7KA 4AKGA 2CJ4A 1OAHA 1S26A 2R05A 1X90A 2OEVA 2PNRA 5BRKA 2A1TA 3AFEA 5M4NA 4L3XA 3TZ0A 2COLA 1RX0A 3F29A 4H81A 4KTOA 4N5FA 2JBRA 4X28C 4FZ4A 1PK0A
chains in the Genus database with same CATH topology
2F6LA 4FF3A 2EBHX 4FF2A 2EBFX 3VKGA 2GBBA 1XFYA 4P79A 1K8TA 4HKRA 2VF1A 4QICA 2FP2A 2AZEA 2EC5A 1XFVA 3KMLA 3C46A 3X29A 1YRUA 2QR4A 3Q0AA 5GJWE 1LVCA 3Q22A 1K93A 1XFZA 1Y0VA 3CE2A 4G97A 4F0XA 3Q23A 1ZOTA 3Q24A 3VKHA 4AKIA 4AKGA 2AO2A 4KS9A 3N0RA 1S26A 1K90A 4KSAA 5GJVE 4FF1A 3C2PA 4FF4A 1RP3A 1SC5A 1XFWA 1XFXA 2FP1A 2LFWA 3C3LA 4AKHA 2COLA 1XFUA 1SK6A 4AI6A 4KSFA 1YRTA 2PO4A 2YGWA 4FZ4A 4HKSA 1PK0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2COL A;  1YRU A;  1XFW A;  1XFU A;  1LVC A;  1K93 A;  1XFZ A;  1SK6 A;  1XFY A;  1S26 A;  1K90 A;  1K8T A;  1XFX A;  1Y0V A;  1YRT A;  1ZOT A;  1XFV A;  1PK0 A; 
#chains in the Genus database with same CATH topology
 2Q8F A;  4FF2 A;  3OWM A;  2RF7 A;  3M9V A;  3OIB A;  2PG0 A;  5M4M A;  4HKR A;  2AZE A;  2BU6 A;  2EC5 A;  2OEX A;  2RDZ A;  5J6A A;  1R2J A;  2YYI A;  3X0Y A;  3C46 A;  3SCE A;  1JQI A;  3SWO A;  1XFZ A;  2E81 A;  2WBI A;  3CE2 A;  3UBR A;  3Q23 A;  5B5V A;  2ZDX A;  2Q8H A;  4L3Z A;  1R3B A;  1Y8P A;  3MDD A;  4L3Y A;  4MPN A;  4Q17 A;  4W9U A;  4WJY A;  3N0R A;  5J71 A;  5B6B A;  5K3I A;  4KSA A;  2YYM A;  4H7Q A;  4FF1 A;  3RKH A;  1XFX A;  5K3H A;  3C3L A;  1W07 A;  3TZ2 A;  3SF6 A;  3BNH A;  2R03 A;  3MPI A;  4JIZ A;  2BU8 A;  4KSF A;  2JBS A;  3LGQ A;  1YRT A;  2BU7 A;  2PO4 A;  4KCF A;  1FS9 A;  3FO3 A;  2CJ5 A;  4HKS A;  2VF1 A;  4AKI A;  5M4P A;  3D6B A;  2JIF A;  2EBH X;  3TZ5 A;  2R0M A;  3X0X A;  1XFY A;  2IX5 A;  2ZO5 A;  4JIO A;  4P79 A;  4IV6 A;  2FP2 A;  1EGE A;  2OJQ A;  1RJ4 A;  3X29 A;  2QR4 A;  2VIG A;  2C12 A;  3OWA A;  4V25 A;  5GJW E;  4F0X A;  4MP7 A;  2ZAF A;  3TZ4 A;  2OT4 A;  3Q24 A;  3MMO A;  2J7A A;  1EGD A;  3B96 A;  2XS1 A;  2E0A A;  1T9G A;  3BNG A;  1EGC A;  2BU2 A;  4IRN A;  2FON A;  3GM6 A;  3C2P A;  1GKZ A;  3D9F A;  4FF4 A;  2BU5 A;  1FS7 A;  2FP1 A;  2LFW A;  4RM7 A;  4ZXV A;  4AKH A;  3D9D A;  4O5M A;  3BNF A;  2Q8I A;  1SK6 A;  2ZDY A;  3L1T A;  3S7W A;  4V26 A;  3VAD A;  1GJV A;  1IS2 A;  1GU6 A;  2EBA A;  3GNC A;  4Q1O A;  3SXQ A;  1SIQ A;  4E00 A;  2F6L A;  3AFF A;  1QDB A;  2JBT A;  1X8Z A;  2YYJ A;  2Z1Q A;  4E02 A;  1GKX A;  4ZYJ A;  1U8V A;  3VKG A;  1Y8O A;  3MXL A;  4J1V A;  4LQS B;  3LG1 A;  5B5W A;  3NF4 A;  1XFV A;  2E80 A;  2XS8 A;  4Q0T A;  2UXW A;  4G5E A;  3II9 A;  4OO2 A;  3Q22 A;  2CJ8 A;  3D2R A;  2OR0 A;  4G97 A;  3CRL A;  4Q4U A;  1ZOT A;  4M9A A;  4X28 A;  3VKH A;  2VR0 A;  4L38 A;  3TOR A;  2D29 A;  3MDE A;  4NXL A;  2AO2 A;  5M4K A;  3MKH A;  4KS9 A;  2BTZ A;  2YYL A;  4HR3 A;  4MPC A;  4MPE A;  2Q8G A;  1K90 A;  1SIR A;  4MP2 A;  4L1F A;  3P4T A;  5GJV E;  1IVH A;  1WS9 A;  1X91 A;  1Y8N A;  2IX6 A;  2R02 A;  4XVX A;  1RP3 A;  1SC5 A;  1XFW A;  2XQR B;  2ZKJ A;  5BRM A;  1XFU A;  3GQT A;  4H85 A;  4Q5B A;  4Q5C A;  2CJ7 A;  2RFQ A;  4AI6 A;  1BUC A;  3EON A;  1JM6 A;  1UDY A;  2YGW A;  4DZY A;  3PFD A;  4P13 A;  1RJ1 A;  1FS8 A;  4FF3 A;  2EBF X;  2CX9 A;  4JEK A;  2GBB A;  4DOY A;  3UU9 A;  1K8T A;  3MPJ A;  3FCJ A;  1UKW A;  2DVL A;  3HWC A;  4QIC A;  3KML A;  2YYK A;  2HJN A;  1PI1 A;  5K3G A;  3BNJ A;  1YRU A;  4U83 A;  3D1I A;  3Q0A A;  2CJ6 A;  1LVC A;  3D9G A;  1K93 A;  1Y0V A;  2DDH A;  1XG2 B;  2R0N A;  3D9E A;  2C0U A;  4LQQ B;  5K3J A;  3CRK A;  3EOM A;  2REH A;  3TTB A;  2YYG A;  4E01 A;  3R7K A;  4AKG A;  2CJ4 A;  1OAH A;  1S26 A;  2R05 A;  1X90 A;  2OEV A;  2PNR A;  5BRK A;  2A1T A;  3AFE A;  5M4N A;  4L3X A;  3TZ0 A;  2COL A;  1RX0 A;  3F29 A;  4H81 A;  4KTO A;  4N5F A;  2JBR A;  4X28 C;  4FZ4 A;  1PK0 A; 
#chains in the Genus database with same CATH homology
 2F6L A;  4FF3 A;  2EBH X;  4FF2 A;  2EBF X;  3VKG A;  2GBB A;  1XFY A;  4P79 A;  1K8T A;  4HKR A;  2VF1 A;  4QIC A;  2FP2 A;  2AZE A;  2EC5 A;  1XFV A;  3KML A;  3C46 A;  3X29 A;  1YRU A;  2QR4 A;  3Q0A A;  5GJW E;  1LVC A;  3Q22 A;  1K93 A;  1XFZ A;  1Y0V A;  3CE2 A;  4G97 A;  4F0X A;  3Q23 A;  1ZOT A;  3Q24 A;  3VKH A;  4AKI A;  4AKG A;  2AO2 A;  4KS9 A;  3N0R A;  1S26 A;  1K90 A;  4KSA A;  5GJV E;  4FF1 A;  3C2P A;  4FF4 A;  1RP3 A;  1SC5 A;  1XFW A;  1XFX A;  2FP1 A;  2LFW A;  3C3L A;  4AKH A;  2COL A;  1XFU A;  1SK6 A;  4AI6 A;  4KSF A;  1YRT A;  2PO4 A;  2YGW A;  4FZ4 A;  4HKS A;  1PK0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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