4P13A

Medium chain acyl-coa dehydrogenase, k304e mutant
Total Genus 146
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
146
sequence length
387
structure length
387
Chain Sequence
LGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMEVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
publication title Medium chain acyl-CoA dehydrogenase, K304E mutant
rcsb
source organism Homo sapiens
molecule tags Oxidoreductase
total genus 146
structure length 387
sequence length 387
chains with identical sequence B, C, D
ec nomenclature ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date 2014-02-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 4p13A01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 4p13A03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 4p13A02
3MDEA 4IV6A 3EONA 1FS7A 3EOMA 1R2JA 2EBAA 1IS2A 3R7KA 1UKWA 4RM7A 2RFQA 3MDDA 2JBTA 3SF6A 3FO3A 3SXQA 2PG0A 2J7AA 5K3IA 2CX9A 3GNCA 3MXLA 3P4TA 1FS8A 2Z1QA 2WBIA 3X0XA 1SIQA 1RX0A 2ZO5A 3GQTA 1EGCA 4NXLA 3D6BA 3D9GA 3S7WA 3MKHA 2R0NA 2OR0A 4W9UA 2DVLA 1FS9A 3D9EA 2YYKA 4L38A 2DDHA 4M9AA 4KTOA 4P13A 4HR3A 4L3ZA 3MPIA 5K3HA 2E80A 3F29A 3HWCA 4L1FA 3MMOA 3UU9A 1T9GA 3AFFA 4Q0TA 2VIGA 4L3YA 3TTBA 3OWMA 2OT4A 3UBRA 3BNJA 3GM6A 4DOYA 3NF4A 3SWOA 3D9FA 3FCJA 3X0YA 2YYGA 1SIRA 2A1TA 1IVHA 2JBRA 2UXWA 4XVXA 1UDYA 1EGEA 2E81A 3OWAA 4Q5BA 1BUCA 2JIFA 3LG1A 4Q17A 3RKHA 2RF7A 4O5MA 2YYJA 3B96A 3OIBA 3MPJA 2R0MA 4Q4UA 3D1IA 4KCFA 2JBSA 2YYIA 5K3GA 3D9DA 1JQIA 4OO2A 2ZAFA 4ZYJA 1U8VA 3PFDA 2RDZA 1W07A 4X28A 4JEKA 2IX6A 3II9A 4IRNA 2C0UA 2VR0A 1EGDA 4N5FA 4L3XA 1OAHA 3M9VA 1QDBA 3TORA 4X28C 3L1TA 4Q1OA 2IX5A 4WJYA 3LGQA 3SCEA 2C12A 3BNFA 2FONA 3BNGA 3AFEA 4ZXVA 2YYLA 2YYMA 2REHA 3BNHA 1WS9A 1GU6A 4U83A 5K3JA 4G5EA 4Q5CA 2D29A
chains in the Genus database with same CATH superfamily
3MDEA 1RJ4A 1X91A 1RP3A 3X29A 1S26A 4IV6A 3EONA 1FS7A 2BTZA 3EOMA 2XS1A 1R2JA 2EBAA 1SK6A 2OEVA 1IS2A 3R7KA 1UKWA 2FP2A 3DJLA 2CJ7A 4RM7A 2BU5A 2RFQA 2R03A 3MDDA 2JBTA 3SF6A 4FF3A 3FO3A 3SXQA 4AKHA 2PG0A 1GKZA 1XFZA 2J7AA 5K3IA 2EBHX 2CX9A 3GNCA 3CE2A 3MXLA 3P4TA 5B5VA 3TZ0A 2Q8FA 1JM6A 1FS8A 4MPCA 2ZDXA 4MP2A 2Z1QA 2WBIA 3X0XA 1SIQA 1RX0A 2ZKJA 2ZO5A 3GQTA 1EGCA 4G97A 4NXLA 3D6BA 3Q23A 3TZ5A 3D9GA 2Q8GA 5M4NA 3S7WA 3MKHA 1GKXA 1Y8PA 2XS8A 4MP7A 2R0NA 1LVCA 1PI1A 4LQQB 2OR0A 4HKSA 1XFYA 4W9UA 5B5WA 2BU2A 1XFVA 2DVLA 1R3BA 4AKIA 1FS9A 2BU7A 3KMLA 3D9EA 4Q5CA 2YYKA 5J71A 1Y8OA 4J1VA 4H7QA 4L38A 4JIZA 2Q8HA 2DDHA 4V26A 4M9AA 4KTOA 4P13A 4MPEA 1PK0A 4HR3A 3C46A 4L3ZA 3MPIA 2FP1A 2GBBA 5K3HA 4QICA 2E80A 3D2RA 3F29A 3TZ2A 1K93A 3HWCA 4HKRA 4L1FA 3MMOA 5GJVE 3UU9A 1XFUA 1T9GA 1RJ1A 2BU8A 3AFFA 4KS9A 2VIGA 4L3YA 4Q0TA 3TTBA 3OWMA 2OT4A 3UBRA 4DZYA 3BNJA 3GM6A 4DOYA 3NF4A 3SWOA 3D9FA 3FCJA 3X0YA 1XFWA 2QR4A 2YYGA 1SIRA 2A1TA 1IVHA 2E0AA 1GJVA 1XG2B 2AZEA 2JBRA 2UXWA 4XVXA 5M4KA 3N0RA 1K8TA 4KSFA 4FF2A 2OEXA 3CRKA 2Q8IA 1UDYA 2HJNA 1EGEA 2E81A 3OWAA 5M4PA 4Q5BA 4KSAA 1BUCA 2JIFA 3C2PA 2AO2A 3LG1A 2LFWA 4Q17A 3VADA 3RKHA 2RF7A 2CJ8A 4O5MA 3TZ4A 4AI6A 3CRLA 1X8ZA 2YYJA 5EZ3A 4F0XA 5M4MA 2XQRB 3VKHA 2EC5A 1K90A 3B96A 1SC5A 1Y8NA 2R02A 3OIBA 3Q24A 3MPJA 2R0MA 4H85A 2OJQA 3U33A 4JIOA 2CJ4A 4Q4UA 3D1IA 4KCFA 2JBSA 2YYIA 5BRMA 1X90A 5K3GA 2YGWA 3D9DA 1JQIA 4H81A 4OO2A 4AKGA 2PNRA 2ZAFA 4ZYJA 1U8VA 4P79A 3PFDA 5GJWE 2RDZA 5BRKA 1W07A 4X28A 2BU6A 4JEKA 2IX6A 4FZ4A 3II9A 3Q0AA 2PO4A 2ZDYA 4IRNA 2C0UA 1Y0VA 2VR0A 1EGDA 4FF4A 2R05A 4N5FA 2CJ6A 2VF1A 3VKGA 4L3XA 1OAHA 3M9VA 1QDBA 3TORA 4X28C 5J6AA 3C3LA 3L1TA 4Q1OA 4V25A 2IX5A 4E02A 4WJYA 3LGQA 3SCEA 4E01A 2C12A 3BNFA 4MPNA 2FONA 1XFXA 3BNGA 3AFEA 4LQSB 4ZXVA 2YYLA 2YYMA 3Q22A 4E00A 2REHA 2CJ5A 2F6LA 3BNHA 1WS9A 1GU6A 4U83A 5K3JA 2EBFX 4G5EA 2D29A 4FF1A 5B6BA
chains in the Genus database with same CATH topology
3MDEA 4IV6A 3EONA 1FS7A 3EOMA 1R2JA 2EBAA 1IS2A 3R7KA 1UKWA 4RM7A 2RFQA 3MDDA 2JBTA 3SF6A 3FO3A 3SXQA 2PG0A 2J7AA 5K3IA 2CX9A 3GNCA 3MXLA 3P4TA 1FS8A 2Z1QA 2WBIA 3X0XA 1SIQA 1RX0A 2ZO5A 3GQTA 1EGCA 4NXLA 3D6BA 3D9GA 3S7WA 3MKHA 2R0NA 2OR0A 4W9UA 2DVLA 1FS9A 3D9EA 2YYKA 4L38A 2DDHA 4M9AA 4KTOA 4P13A 4HR3A 4L3ZA 3MPIA 5K3HA 2E80A 3F29A 3HWCA 4L1FA 3MMOA 3UU9A 1T9GA 3AFFA 4Q0TA 2VIGA 4L3YA 3TTBA 3OWMA 2OT4A 3UBRA 3BNJA 3GM6A 4DOYA 3NF4A 3SWOA 3D9FA 3FCJA 3X0YA 2YYGA 1SIRA 2A1TA 1IVHA 2JBRA 2UXWA 4XVXA 1UDYA 1EGEA 2E81A 3OWAA 4Q5BA 1BUCA 2JIFA 3LG1A 4Q17A 3RKHA 2RF7A 4O5MA 2YYJA 3B96A 3OIBA 3MPJA 2R0MA 4Q4UA 3D1IA 4KCFA 2JBSA 2YYIA 5K3GA 3D9DA 1JQIA 4OO2A 2ZAFA 4ZYJA 1U8VA 3PFDA 2RDZA 1W07A 4X28A 4JEKA 2IX6A 3II9A 4IRNA 2C0UA 2VR0A 1EGDA 4N5FA 4L3XA 1OAHA 3M9VA 1QDBA 3TORA 4X28C 3L1TA 4Q1OA 2IX5A 4WJYA 3LGQA 3SCEA 2C12A 3BNFA 2FONA 3BNGA 3AFEA 4ZXVA 2YYLA 2YYMA 2REHA 3BNHA 1WS9A 1GU6A 4U83A 5K3JA 4G5EA 4Q5CA 2D29A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MDE A;  4IV6 A;  3EON A;  1FS7 A;  3EOM A;  1R2J A;  2EBA A;  1IS2 A;  3R7K A;  1UKW A;  4RM7 A;  2RFQ A;  3MDD A;  2JBT A;  3SF6 A;  3FO3 A;  3SXQ A;  2PG0 A;  2J7A A;  5K3I A;  2CX9 A;  3GNC A;  3MXL A;  3P4T A;  1FS8 A;  2Z1Q A;  2WBI A;  3X0X A;  1SIQ A;  1RX0 A;  2ZO5 A;  3GQT A;  1EGC A;  4NXL A;  3D6B A;  3D9G A;  3S7W A;  3MKH A;  2R0N A;  2OR0 A;  4W9U A;  2DVL A;  1FS9 A;  3D9E A;  2YYK A;  4L38 A;  2DDH A;  4M9A A;  4KTO A;  4P13 A;  4HR3 A;  4L3Z A;  3MPI A;  5K3H A;  2E80 A;  3F29 A;  3HWC A;  4L1F A;  3MMO A;  3UU9 A;  1T9G A;  3AFF A;  4Q0T A;  2VIG A;  4L3Y A;  3TTB A;  3OWM A;  2OT4 A;  3UBR A;  3BNJ A;  3GM6 A;  4DOY A;  3NF4 A;  3SWO A;  3D9F A;  3FCJ A;  3X0Y A;  2YYG A;  1SIR A;  2A1T A;  1IVH A;  2JBR A;  2UXW A;  4XVX A;  1UDY A;  1EGE A;  2E81 A;  3OWA A;  4Q5B A;  1BUC A;  2JIF A;  3LG1 A;  4Q17 A;  3RKH A;  2RF7 A;  4O5M A;  2YYJ A;  3B96 A;  3OIB A;  3MPJ A;  2R0M A;  4Q4U A;  3D1I A;  4KCF A;  2JBS A;  2YYI A;  5K3G A;  3D9D A;  1JQI A;  4OO2 A;  2ZAF A;  4ZYJ A;  1U8V A;  3PFD A;  2RDZ A;  1W07 A;  4X28 A;  4JEK A;  2IX6 A;  3II9 A;  4IRN A;  2C0U A;  2VR0 A;  1EGD A;  4N5F A;  4L3X A;  1OAH A;  3M9V A;  1QDB A;  3TOR A;  4X28 C;  3L1T A;  4Q1O A;  2IX5 A;  4WJY A;  3LGQ A;  3SCE A;  2C12 A;  3BNF A;  2FON A;  3BNG A;  3AFE A;  4ZXV A;  2YYL A;  2YYM A;  2REH A;  3BNH A;  1WS9 A;  1GU6 A;  4U83 A;  5K3J A;  4G5E A;  4Q5C A;  2D29 A; 
#chains in the Genus database with same CATH topology
 3MDE A;  1RJ4 A;  1X91 A;  1RP3 A;  3X29 A;  1S26 A;  4IV6 A;  3EON A;  1FS7 A;  2BTZ A;  3EOM A;  2XS1 A;  1R2J A;  2EBA A;  1SK6 A;  2OEV A;  1IS2 A;  3R7K A;  1UKW A;  2FP2 A;  3DJL A;  2CJ7 A;  4RM7 A;  2BU5 A;  2RFQ A;  2R03 A;  3MDD A;  2JBT A;  3SF6 A;  4FF3 A;  3FO3 A;  3SXQ A;  4AKH A;  2PG0 A;  1GKZ A;  1XFZ A;  2J7A A;  5K3I A;  2EBH X;  2CX9 A;  3GNC A;  3CE2 A;  3MXL A;  3P4T A;  5B5V A;  3TZ0 A;  2Q8F A;  1JM6 A;  1FS8 A;  4MPC A;  2ZDX A;  4MP2 A;  2Z1Q A;  2WBI A;  3X0X A;  1SIQ A;  1RX0 A;  2ZKJ A;  2ZO5 A;  3GQT A;  1EGC A;  4G97 A;  4NXL A;  3D6B A;  3Q23 A;  3TZ5 A;  3D9G A;  2Q8G A;  5M4N A;  3S7W A;  3MKH A;  1GKX A;  1Y8P A;  2XS8 A;  4MP7 A;  2R0N A;  1LVC A;  1PI1 A;  4LQQ B;  2OR0 A;  4HKS A;  1XFY A;  4W9U A;  5B5W A;  2BU2 A;  1XFV A;  2DVL A;  1R3B A;  4AKI A;  1FS9 A;  2BU7 A;  3KML A;  3D9E A;  4Q5C A;  2YYK A;  5J71 A;  1Y8O A;  4J1V A;  4H7Q A;  4L38 A;  4JIZ A;  2Q8H A;  2DDH A;  4V26 A;  4M9A A;  4KTO A;  4P13 A;  4MPE A;  1PK0 A;  4HR3 A;  3C46 A;  4L3Z A;  3MPI A;  2FP1 A;  2GBB A;  5K3H A;  4QIC A;  2E80 A;  3D2R A;  3F29 A;  3TZ2 A;  1K93 A;  3HWC A;  4HKR A;  4L1F A;  3MMO A;  5GJV E;  3UU9 A;  1XFU A;  1T9G A;  1RJ1 A;  2BU8 A;  3AFF A;  4KS9 A;  2VIG A;  4L3Y A;  4Q0T A;  3TTB A;  3OWM A;  2OT4 A;  3UBR A;  4DZY A;  3BNJ A;  3GM6 A;  4DOY A;  3NF4 A;  3SWO A;  3D9F A;  3FCJ A;  3X0Y A;  1XFW A;  2QR4 A;  2YYG A;  1SIR A;  2A1T A;  1IVH A;  2E0A A;  1GJV A;  1XG2 B;  2AZE A;  2JBR A;  2UXW A;  4XVX A;  5M4K A;  3N0R A;  1K8T A;  4KSF A;  4FF2 A;  2OEX A;  3CRK A;  2Q8I A;  1UDY A;  2HJN A;  1EGE A;  2E81 A;  3OWA A;  5M4P A;  4Q5B A;  4KSA A;  1BUC A;  2JIF A;  3C2P A;  2AO2 A;  3LG1 A;  2LFW A;  4Q17 A;  3VAD A;  3RKH A;  2RF7 A;  2CJ8 A;  4O5M A;  3TZ4 A;  4AI6 A;  3CRL A;  1X8Z A;  2YYJ A;  5EZ3 A;  4F0X A;  5M4M A;  2XQR B;  3VKH A;  2EC5 A;  1K90 A;  3B96 A;  1SC5 A;  1Y8N A;  2R02 A;  3OIB A;  3Q24 A;  3MPJ A;  2R0M A;  4H85 A;  2OJQ A;  3U33 A;  4JIO A;  2CJ4 A;  4Q4U A;  3D1I A;  4KCF A;  2JBS A;  2YYI A;  5BRM A;  1X90 A;  5K3G A;  2YGW A;  3D9D A;  1JQI A;  4H81 A;  4OO2 A;  4AKG A;  2PNR A;  2ZAF A;  4ZYJ A;  1U8V A;  4P79 A;  3PFD A;  5GJW E;  2RDZ A;  5BRK A;  1W07 A;  4X28 A;  2BU6 A;  4JEK A;  2IX6 A;  4FZ4 A;  3II9 A;  3Q0A A;  2PO4 A;  2ZDY A;  4IRN A;  2C0U A;  1Y0V A;  2VR0 A;  1EGD A;  4FF4 A;  2R05 A;  4N5F A;  2CJ6 A;  2VF1 A;  3VKG A;  4L3X A;  1OAH A;  3M9V A;  1QDB A;  3TOR A;  4X28 C;  5J6A A;  3C3L A;  3L1T A;  4Q1O A;  4V25 A;  2IX5 A;  4E02 A;  4WJY A;  3LGQ A;  3SCE A;  4E01 A;  2C12 A;  3BNF A;  4MPN A;  2FON A;  1XFX A;  3BNG A;  3AFE A;  4LQS B;  4ZXV A;  2YYL A;  2YYM A;  3Q22 A;  4E00 A;  2REH A;  2CJ5 A;  2F6L A;  3BNH A;  1WS9 A;  1GU6 A;  4U83 A;  5K3J A;  2EBF X;  4G5E A;  2D29 A;  4FF1 A;  5B6B A; 
#chains in the Genus database with same CATH homology
 3MDE A;  4IV6 A;  3EON A;  1FS7 A;  3EOM A;  1R2J A;  2EBA A;  1IS2 A;  3R7K A;  1UKW A;  4RM7 A;  2RFQ A;  3MDD A;  2JBT A;  3SF6 A;  3FO3 A;  3SXQ A;  2PG0 A;  2J7A A;  5K3I A;  2CX9 A;  3GNC A;  3MXL A;  3P4T A;  1FS8 A;  2Z1Q A;  2WBI A;  3X0X A;  1SIQ A;  1RX0 A;  2ZO5 A;  3GQT A;  1EGC A;  4NXL A;  3D6B A;  3D9G A;  3S7W A;  3MKH A;  2R0N A;  2OR0 A;  4W9U A;  2DVL A;  1FS9 A;  3D9E A;  2YYK A;  4L38 A;  2DDH A;  4M9A A;  4KTO A;  4P13 A;  4HR3 A;  4L3Z A;  3MPI A;  5K3H A;  2E80 A;  3F29 A;  3HWC A;  4L1F A;  3MMO A;  3UU9 A;  1T9G A;  3AFF A;  4Q0T A;  2VIG A;  4L3Y A;  3TTB A;  3OWM A;  2OT4 A;  3UBR A;  3BNJ A;  3GM6 A;  4DOY A;  3NF4 A;  3SWO A;  3D9F A;  3FCJ A;  3X0Y A;  2YYG A;  1SIR A;  2A1T A;  1IVH A;  2JBR A;  2UXW A;  4XVX A;  1UDY A;  1EGE A;  2E81 A;  3OWA A;  4Q5B A;  1BUC A;  2JIF A;  3LG1 A;  4Q17 A;  3RKH A;  2RF7 A;  4O5M A;  2YYJ A;  3B96 A;  3OIB A;  3MPJ A;  2R0M A;  4Q4U A;  3D1I A;  4KCF A;  2JBS A;  2YYI A;  5K3G A;  3D9D A;  1JQI A;  4OO2 A;  2ZAF A;  4ZYJ A;  1U8V A;  3PFD A;  2RDZ A;  1W07 A;  4X28 A;  4JEK A;  2IX6 A;  3II9 A;  4IRN A;  2C0U A;  2VR0 A;  1EGD A;  4N5F A;  4L3X A;  1OAH A;  3M9V A;  1QDB A;  3TOR A;  4X28 C;  3L1T A;  4Q1O A;  2IX5 A;  4WJY A;  3LGQ A;  3SCE A;  2C12 A;  3BNF A;  2FON A;  3BNG A;  3AFE A;  4ZXV A;  2YYL A;  2YYM A;  2REH A;  3BNH A;  1WS9 A;  1GU6 A;  4U83 A;  5K3J A;  4G5E A;  4Q5C A;  2D29 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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