4P13A

Medium chain acyl-coa dehydrogenase, k304e mutant
Total Genus 146
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
146
sequence length
387
structure length
387
Chain Sequence
LGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMEVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
publication title Medium chain acyl-CoA dehydrogenase, K304E mutant
rcsb
source organism Homo sapiens
molecule tags Oxidoreductase
total genus 146
structure length 387
sequence length 387
chains with identical sequence B, C, D
ec nomenclature ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date 2014-02-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 4p13A01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 4p13A03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 4p13A02
3MDEA 3X0XA 3UBRA 3FCJA 3D9DA 2OT4A 3LG1A 3R7KA 1UDYA 3S7WA 3MPJA 2YYGA 3TTBA 3P4TA 1EGCA 2REHA 2R0NA 2DDHA 4L3XA 2YYLA 3EOMA 4XVXA 2JBSA 1U8VA 2JBRA 4L38A 5K3HA 4L1FA 3B96A 2VIGA 1FS8A 2E80A 3SF6A 1UKWA 3MXLA 4Q4UA 4L3ZA 2R0MA 1SIRA 4RM7A 4KTOA 2YYJA 3BNJA 4WJYA 2VR0A 3MKHA 3MMOA 2IX5A 2UXWA 3MDDA 1BUCA 1W07A 3TORA 2DVLA 3MPIA 1FS7A 2RDZA 2EBAA 4ZXVA 4ZYJA 3D1IA 4KCFA 3NF4A 5K3JA 4Q5BA 4W9UA 2A1TA 4Q0TA 2RF7A 2YYKA 4Q5CA 4IRNA 2IX6A 5K3IA 2CX9A 3LGQA 1EGEA 3M9VA 2E81A 3UU9A 1T9GA 4X28C 1R2JA 3OIBA 4Q17A 3BNFA 1SIQA 3OWAA 3GM6A 2PG0A 1JQIA 1RX0A 2FONA 3BNGA 4HR3A 4DOYA 4O5MA 2J7AA 1FS9A 4G5EA 4IV6A 3SWOA 2C12A 3SCEA 5K3GA 3BNHA 1IS2A 2ZAFA 4U83A 2JBTA 3EONA 1EGDA 1GU6A 3OWMA 4JEKA 3GQTA 2RFQA 1OAHA 2ZO5A 4N5FA 3HWCA 3II9A 4Q1OA 2D29A 4OO2A 3D9EA 3GNCA 2WBIA 3RKHA 3FO3A 4X28A 4P13A 3PFDA 4NXLA 2JIFA 4L3YA 3AFFA 2OR0A 2Z1QA 3D9FA 1IVHA 1QDBA 2YYMA 3F29A 3SXQA 2C0UA 3L1TA 3D6BA 2YYIA 1WS9A 3X0YA 3AFEA 3D9GA 4M9AA
chains in the Genus database with same CATH superfamily
3MDEA 4H81A 4E02A 2CJ6A 3X0XA 1K90A 3UBRA 3X29A 2EC5A 3FCJA 2FP1A 3D9DA 2OT4A 3LG1A 2Q8IA 2R03A 3R7KA 4FF1A 4AKGA 4KS9A 1UDYA 2GBBA 3S7WA 3Q22A 4FF2A 3MPJA 2YYGA 5M4MA 4H7QA 4HKRA 4MPNA 3TTBA 3P4TA 2ZDYA 3KMLA 4JIZA 5J71A 1K93A 1EGCA 2REHA 2R0NA 4MP2A 2CJ7A 5J6AA 2DDHA 2Q8GA 2QR4A 4LQQB 2BU7A 2CJ8A 4L3XA 2YYLA 3EOMA 4XVXA 1Y8OA 2JBSA 5GJWE 3TZ4A 4JIOA 1U8VA 2BU5A 4QICA 2JBRA 1RP3A 4L38A 5K3HA 4L1FA 3B96A 2VIGA 1FS8A 2E80A 3SF6A 2YGWA 4G97A 1UKWA 3MXLA 4Q4UA 5BRKA 4L3ZA 2R0MA 4DZYA 5M4PA 1SIRA 5GJVE 4RM7A 1PI1A 1RJ4A 1X8ZA 4KTOA 2OJQA 2YYJA 3BNJA 1S26A 4H85A 4WJYA 3C3LA 1Y0VA 2HJNA 2VR0A 3D2RA 3MKHA 3MMOA 4KSAA 2IX5A 2UXWA 3MDDA 1LVCA 1BUCA 1W07A 1XG2B 3TORA 1XFVA 2XS8A 3DJLA 2DVLA 5B5VA 2BTZA 3MPIA 1K8TA 1FS7A 2XS1A 4FF4A 2RDZA 2EBAA 1GKZA 1SK6A 2VF1A 1R3BA 4AKHA 4ZXVA 4ZYJA 3D1IA 4KCFA 3NF4A 5K3JA 2AO2A 1XFZA 4Q5BA 2Q8HA 4W9UA 2A1TA 4FZ4A 4F0XA 4Q0TA 2RF7A 3VKGA 4J1VA 2YYKA 1JM6A 4Q5CA 4MPEA 4IRNA 2IX6A 5K3IA 1GJVA 1GKXA 2CX9A 4E00A 4MPCA 2LFWA 3LGQA 1EGEA 3M9VA 2E81A 3UU9A 1T9GA 5EZ3A 4X28C 1R2JA 3OIBA 4Q17A 3BNFA 4KSFA 1SIQA 2PO4A 2ZDXA 3VKHA 3OWAA 1XFUA 3GM6A 2PG0A 1Y8NA 1JQIA 1RX0A 2FONA 2EBFX 2OEXA 3BNGA 1PK0A 2BU6A 2F6LA 4HR3A 4P79A 3CRKA 4DOYA 4O5MA 5B5WA 2J7AA 4FF3A 1FS9A 4G5EA 2PNRA 1Y8PA 4IV6A 3SWOA 2R05A 2C12A 3SCEA 2EBHX 3U33A 5K3GA 2FP2A 3BNHA 1XFXA 1IS2A 3TZ0A 2ZAFA 4U83A 2JBTA 3EONA 4AKIA 5B6BA 4LQSB 1EGDA 1RJ1A 2XQRB 1GU6A 3OWMA 4JEKA 4AI6A 3GQTA 1X90A 3VADA 1XFYA 2RFQA 1OAHA 2ZO5A 5M4NA 4N5FA 3HWCA 2R02A 3II9A 2CJ5A 2D29A 4OO2A 2ZKJA 3D9EA 3GNCA 4Q1OA 3Q0AA 2Q8FA 2OEVA 2WBIA 3RKHA 3CRLA 3CE2A 3FO3A 4X28A 2BU8A 4P13A 1XFWA 3PFDA 4NXLA 2JIFA 4L3YA 3AFFA 3TZ5A 3N0RA 4E01A 2OR0A 3Q24A 2Z1QA 3D9FA 1IVHA 1QDBA 2CJ4A 2YYMA 3F29A 3SXQA 2C0UA 5M4KA 3L1TA 3C46A 3D6BA 3TZ2A 2BU2A 3Q23A 1X91A 2YYIA 1SC5A 2E0AA 2AZEA 4V25A 1WS9A 3C2PA 3X0YA 3AFEA 3D9GA 4V26A 5BRMA 4M9AA 4MP7A 4HKSA
chains in the Genus database with same CATH topology
3MDEA 3X0XA 3UBRA 3FCJA 3D9DA 2OT4A 3LG1A 3R7KA 1UDYA 3S7WA 3MPJA 2YYGA 3TTBA 3P4TA 1EGCA 2REHA 2R0NA 2DDHA 4L3XA 2YYLA 3EOMA 4XVXA 2JBSA 1U8VA 2JBRA 4L38A 5K3HA 4L1FA 3B96A 2VIGA 1FS8A 2E80A 3SF6A 1UKWA 3MXLA 4Q4UA 4L3ZA 2R0MA 1SIRA 4RM7A 4KTOA 2YYJA 3BNJA 4WJYA 2VR0A 3MKHA 3MMOA 2IX5A 2UXWA 3MDDA 1BUCA 1W07A 3TORA 2DVLA 3MPIA 1FS7A 2RDZA 2EBAA 4ZXVA 4ZYJA 3D1IA 4KCFA 3NF4A 5K3JA 4Q5BA 4W9UA 2A1TA 4Q0TA 2RF7A 2YYKA 4Q5CA 4IRNA 2IX6A 5K3IA 2CX9A 3LGQA 1EGEA 3M9VA 2E81A 3UU9A 1T9GA 4X28C 1R2JA 3OIBA 4Q17A 3BNFA 1SIQA 3OWAA 3GM6A 2PG0A 1JQIA 1RX0A 2FONA 3BNGA 4HR3A 4DOYA 4O5MA 2J7AA 1FS9A 4G5EA 4IV6A 3SWOA 2C12A 3SCEA 5K3GA 3BNHA 1IS2A 2ZAFA 4U83A 2JBTA 3EONA 1EGDA 1GU6A 3OWMA 4JEKA 3GQTA 2RFQA 1OAHA 2ZO5A 4N5FA 3HWCA 3II9A 4Q1OA 2D29A 4OO2A 3D9EA 3GNCA 2WBIA 3RKHA 3FO3A 4X28A 4P13A 3PFDA 4NXLA 2JIFA 4L3YA 3AFFA 2OR0A 2Z1QA 3D9FA 1IVHA 1QDBA 2YYMA 3F29A 3SXQA 2C0UA 3L1TA 3D6BA 2YYIA 1WS9A 3X0YA 3AFEA 3D9GA 4M9AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MDE A;  3X0X A;  3UBR A;  3FCJ A;  3D9D A;  2OT4 A;  3LG1 A;  3R7K A;  1UDY A;  3S7W A;  3MPJ A;  2YYG A;  3TTB A;  3P4T A;  1EGC A;  2REH A;  2R0N A;  2DDH A;  4L3X A;  2YYL A;  3EOM A;  4XVX A;  2JBS A;  1U8V A;  2JBR A;  4L38 A;  5K3H A;  4L1F A;  3B96 A;  2VIG A;  1FS8 A;  2E80 A;  3SF6 A;  1UKW A;  3MXL A;  4Q4U A;  4L3Z A;  2R0M A;  1SIR A;  4RM7 A;  4KTO A;  2YYJ A;  3BNJ A;  4WJY A;  2VR0 A;  3MKH A;  3MMO A;  2IX5 A;  2UXW A;  3MDD A;  1BUC A;  1W07 A;  3TOR A;  2DVL A;  3MPI A;  1FS7 A;  2RDZ A;  2EBA A;  4ZXV A;  4ZYJ A;  3D1I A;  4KCF A;  3NF4 A;  5K3J A;  4Q5B A;  4W9U A;  2A1T A;  4Q0T A;  2RF7 A;  2YYK A;  4Q5C A;  4IRN A;  2IX6 A;  5K3I A;  2CX9 A;  3LGQ A;  1EGE A;  3M9V A;  2E81 A;  3UU9 A;  1T9G A;  4X28 C;  1R2J A;  3OIB A;  4Q17 A;  3BNF A;  1SIQ A;  3OWA A;  3GM6 A;  2PG0 A;  1JQI A;  1RX0 A;  2FON A;  3BNG A;  4HR3 A;  4DOY A;  4O5M A;  2J7A A;  1FS9 A;  4G5E A;  4IV6 A;  3SWO A;  2C12 A;  3SCE A;  5K3G A;  3BNH A;  1IS2 A;  2ZAF A;  4U83 A;  2JBT A;  3EON A;  1EGD A;  1GU6 A;  3OWM A;  4JEK A;  3GQT A;  2RFQ A;  1OAH A;  2ZO5 A;  4N5F A;  3HWC A;  3II9 A;  4Q1O A;  2D29 A;  4OO2 A;  3D9E A;  3GNC A;  2WBI A;  3RKH A;  3FO3 A;  4X28 A;  4P13 A;  3PFD A;  4NXL A;  2JIF A;  4L3Y A;  3AFF A;  2OR0 A;  2Z1Q A;  3D9F A;  1IVH A;  1QDB A;  2YYM A;  3F29 A;  3SXQ A;  2C0U A;  3L1T A;  3D6B A;  2YYI A;  1WS9 A;  3X0Y A;  3AFE A;  3D9G A;  4M9A A; 
#chains in the Genus database with same CATH topology
 3MDE A;  4H81 A;  4E02 A;  2CJ6 A;  3X0X A;  1K90 A;  3UBR A;  3X29 A;  2EC5 A;  3FCJ A;  2FP1 A;  3D9D A;  2OT4 A;  3LG1 A;  2Q8I A;  2R03 A;  3R7K A;  4FF1 A;  4AKG A;  4KS9 A;  1UDY A;  2GBB A;  3S7W A;  3Q22 A;  4FF2 A;  3MPJ A;  2YYG A;  5M4M A;  4H7Q A;  4HKR A;  4MPN A;  3TTB A;  3P4T A;  2ZDY A;  3KML A;  4JIZ A;  5J71 A;  1K93 A;  1EGC A;  2REH A;  2R0N A;  4MP2 A;  2CJ7 A;  5J6A A;  2DDH A;  2Q8G A;  2QR4 A;  4LQQ B;  2BU7 A;  2CJ8 A;  4L3X A;  2YYL A;  3EOM A;  4XVX A;  1Y8O A;  2JBS A;  5GJW E;  3TZ4 A;  4JIO A;  1U8V A;  2BU5 A;  4QIC A;  2JBR A;  1RP3 A;  4L38 A;  5K3H A;  4L1F A;  3B96 A;  2VIG A;  1FS8 A;  2E80 A;  3SF6 A;  2YGW A;  4G97 A;  1UKW A;  3MXL A;  4Q4U A;  5BRK A;  4L3Z A;  2R0M A;  4DZY A;  5M4P A;  1SIR A;  5GJV E;  4RM7 A;  1PI1 A;  1RJ4 A;  1X8Z A;  4KTO A;  2OJQ A;  2YYJ A;  3BNJ A;  1S26 A;  4H85 A;  4WJY A;  3C3L A;  1Y0V A;  2HJN A;  2VR0 A;  3D2R A;  3MKH A;  3MMO A;  4KSA A;  2IX5 A;  2UXW A;  3MDD A;  1LVC A;  1BUC A;  1W07 A;  1XG2 B;  3TOR A;  1XFV A;  2XS8 A;  3DJL A;  2DVL A;  5B5V A;  2BTZ A;  3MPI A;  1K8T A;  1FS7 A;  2XS1 A;  4FF4 A;  2RDZ A;  2EBA A;  1GKZ A;  1SK6 A;  2VF1 A;  1R3B A;  4AKH A;  4ZXV A;  4ZYJ A;  3D1I A;  4KCF A;  3NF4 A;  5K3J A;  2AO2 A;  1XFZ A;  4Q5B A;  2Q8H A;  4W9U A;  2A1T A;  4FZ4 A;  4F0X A;  4Q0T A;  2RF7 A;  3VKG A;  4J1V A;  2YYK A;  1JM6 A;  4Q5C A;  4MPE A;  4IRN A;  2IX6 A;  5K3I A;  1GJV A;  1GKX A;  2CX9 A;  4E00 A;  4MPC A;  2LFW A;  3LGQ A;  1EGE A;  3M9V A;  2E81 A;  3UU9 A;  1T9G A;  5EZ3 A;  4X28 C;  1R2J A;  3OIB A;  4Q17 A;  3BNF A;  4KSF A;  1SIQ A;  2PO4 A;  2ZDX A;  3VKH A;  3OWA A;  1XFU A;  3GM6 A;  2PG0 A;  1Y8N A;  1JQI A;  1RX0 A;  2FON A;  2EBF X;  2OEX A;  3BNG A;  1PK0 A;  2BU6 A;  2F6L A;  4HR3 A;  4P79 A;  3CRK A;  4DOY A;  4O5M A;  5B5W A;  2J7A A;  4FF3 A;  1FS9 A;  4G5E A;  2PNR A;  1Y8P A;  4IV6 A;  3SWO A;  2R05 A;  2C12 A;  3SCE A;  2EBH X;  3U33 A;  5K3G A;  2FP2 A;  3BNH A;  1XFX A;  1IS2 A;  3TZ0 A;  2ZAF A;  4U83 A;  2JBT A;  3EON A;  4AKI A;  5B6B A;  4LQS B;  1EGD A;  1RJ1 A;  2XQR B;  1GU6 A;  3OWM A;  4JEK A;  4AI6 A;  3GQT A;  1X90 A;  3VAD A;  1XFY A;  2RFQ A;  1OAH A;  2ZO5 A;  5M4N A;  4N5F A;  3HWC A;  2R02 A;  3II9 A;  2CJ5 A;  2D29 A;  4OO2 A;  2ZKJ A;  3D9E A;  3GNC A;  4Q1O A;  3Q0A A;  2Q8F A;  2OEV A;  2WBI A;  3RKH A;  3CRL A;  3CE2 A;  3FO3 A;  4X28 A;  2BU8 A;  4P13 A;  1XFW A;  3PFD A;  4NXL A;  2JIF A;  4L3Y A;  3AFF A;  3TZ5 A;  3N0R A;  4E01 A;  2OR0 A;  3Q24 A;  2Z1Q A;  3D9F A;  1IVH A;  1QDB A;  2CJ4 A;  2YYM A;  3F29 A;  3SXQ A;  2C0U A;  5M4K A;  3L1T A;  3C46 A;  3D6B A;  3TZ2 A;  2BU2 A;  3Q23 A;  1X91 A;  2YYI A;  1SC5 A;  2E0A A;  2AZE A;  4V25 A;  1WS9 A;  3C2P A;  3X0Y A;  3AFE A;  3D9G A;  4V26 A;  5BRM A;  4M9A A;  4MP7 A;  4HKS A; 
#chains in the Genus database with same CATH homology
 3MDE A;  3X0X A;  3UBR A;  3FCJ A;  3D9D A;  2OT4 A;  3LG1 A;  3R7K A;  1UDY A;  3S7W A;  3MPJ A;  2YYG A;  3TTB A;  3P4T A;  1EGC A;  2REH A;  2R0N A;  2DDH A;  4L3X A;  2YYL A;  3EOM A;  4XVX A;  2JBS A;  1U8V A;  2JBR A;  4L38 A;  5K3H A;  4L1F A;  3B96 A;  2VIG A;  1FS8 A;  2E80 A;  3SF6 A;  1UKW A;  3MXL A;  4Q4U A;  4L3Z A;  2R0M A;  1SIR A;  4RM7 A;  4KTO A;  2YYJ A;  3BNJ A;  4WJY A;  2VR0 A;  3MKH A;  3MMO A;  2IX5 A;  2UXW A;  3MDD A;  1BUC A;  1W07 A;  3TOR A;  2DVL A;  3MPI A;  1FS7 A;  2RDZ A;  2EBA A;  4ZXV A;  4ZYJ A;  3D1I A;  4KCF A;  3NF4 A;  5K3J A;  4Q5B A;  4W9U A;  2A1T A;  4Q0T A;  2RF7 A;  2YYK A;  4Q5C A;  4IRN A;  2IX6 A;  5K3I A;  2CX9 A;  3LGQ A;  1EGE A;  3M9V A;  2E81 A;  3UU9 A;  1T9G A;  4X28 C;  1R2J A;  3OIB A;  4Q17 A;  3BNF A;  1SIQ A;  3OWA A;  3GM6 A;  2PG0 A;  1JQI A;  1RX0 A;  2FON A;  3BNG A;  4HR3 A;  4DOY A;  4O5M A;  2J7A A;  1FS9 A;  4G5E A;  4IV6 A;  3SWO A;  2C12 A;  3SCE A;  5K3G A;  3BNH A;  1IS2 A;  2ZAF A;  4U83 A;  2JBT A;  3EON A;  1EGD A;  1GU6 A;  3OWM A;  4JEK A;  3GQT A;  2RFQ A;  1OAH A;  2ZO5 A;  4N5F A;  3HWC A;  3II9 A;  4Q1O A;  2D29 A;  4OO2 A;  3D9E A;  3GNC A;  2WBI A;  3RKH A;  3FO3 A;  4X28 A;  4P13 A;  3PFD A;  4NXL A;  2JIF A;  4L3Y A;  3AFF A;  2OR0 A;  2Z1Q A;  3D9F A;  1IVH A;  1QDB A;  2YYM A;  3F29 A;  3SXQ A;  2C0U A;  3L1T A;  3D6B A;  2YYI A;  1WS9 A;  3X0Y A;  3AFE A;  3D9G A;  4M9A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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