1IVHA

Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
387
structure length
387
Chain Sequence
VDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNAD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOVALERYL-COA DEHYDROGENASE
publication title Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.
pubmed doi rcsb
source organism Homo sapiens
total genus 149
structure length 387
sequence length 387
chains with identical sequence B, C, D
ec nomenclature ec 1.3.8.4: Isovaleryl-CoA dehydrogenase.
pdb deposition date 1997-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1ivhA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1ivhA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1ivhA02
3B96A 4Q0TA 2D29A 3D9DA 3BNFA 2EBAA 2R0NA 4L3YA 3GQTA 4JEKA 4ZXVA 1JQIA 1BUCA 4NXLA 3OIBA 3D9FA 3X0XA 1T9GA 3GNCA 3FO3A 3NF4A 2FONA 3L1TA 3R7KA 2UXWA 3MDDA 3SWOA 2JBSA 3EONA 3AFEA 4P13A 4L1FA 1FS7A 4M9AA 4KCFA 2C12A 1R2JA 3LG1A 4Q17A 4OO2A 4HR3A 3HWCA 1IVHA 2YYGA 2VR0A 2VIGA 3X0YA 1EGEA 3OWAA 4N5FA 1U8VA 3EOMA 3M9VA 1SIRA 5K3HA 1OAHA 3LGQA 3BNJA 2IX6A 2JBTA 2A1TA 2DDHA 3MPIA 2YYJA 3S7WA 1UKWA 4L3XA 2RFQA 1SIQA 3SCEA 1UDYA 5K3JA 1GU6A 4Q1OA 2JBRA 4DOYA 1EGCA 1FS9A 3TORA 2RDZA 4Q5CA 3II9A 2Z1QA 3UBRA 3UU9A 3MXLA 3D6BA 2OT4A 2OR0A 4O5MA 3D9EA 2C0UA 2IX5A 2ZAFA 4Q4UA 3FCJA 3MKHA 4IV6A 4L38A 4RM7A 3MDEA 4L3ZA 4X28C 3MMOA 2R0MA 4KTOA 3TTBA 2YYKA 2CX9A 5K3GA 1EGDA 4Q5BA 3D9GA 3MPJA 2WBIA 1FS8A 3RKHA 4U83A 3SXQA 4IRNA 2YYIA 3BNGA 2REHA 4G5EA 4WJYA 1W07A 3D1IA 2J7AA 3AFFA 2DVLA 2E81A 5K3IA 3GM6A 3PFDA 3BNHA 2E80A 4W9UA 2YYMA 3F29A 4ZYJA 2JIFA 3SF6A 2ZO5A 4XVXA 1IS2A 2RF7A 2PG0A 4X28A 2YYLA 3P4TA 1WS9A 3OWMA 1RX0A 1QDBA
chains in the Genus database with same CATH superfamily
2Q8HA 3B96A 4KS9A 4Q0TA 2D29A 3D9DA 3BNFA 4JIOA 4F0XA 4G97A 2EBAA 2R0NA 2XS8A 4L3YA 4FF1A 3GQTA 4JEKA 4ZXVA 1JQIA 2PO4A 1GKZA 4AI6A 1BUCA 4NXLA 1GJVA 4MPCA 5BRKA 5M4KA 3OIBA 3D9FA 3X0XA 3SCEA 1T9GA 3GNCA 2BU5A 3NF4A 3FO3A 2BTZA 2FONA 3L1TA 3R7KA 2UXWA 3MDDA 3SWOA 4P79A 2JBSA 2R03A 3EONA 3AFEA 2BU8A 2FP2A 4HKSA 1SK6A 4P13A 4L1FA 1FS7A 5GJVE 4M9AA 5M4PA 4KCFA 2EBHX 2C12A 2HJNA 3U33A 2QR4A 1R2JA 3LG1A 1GKXA 4Q17A 4OO2A 1XFZA 4HR3A 3VADA 4E00A 4MPEA 4DZYA 3HWCA 4MP2A 2CJ5A 1Y8NA 1IVHA 3Q22A 1XFYA 2XQRB 2YYGA 1LVCA 2VIGA 3X0YA 2VR0A 4FZ4A 4LQQB 4MPNA 3Q0AA 1EGEA 3OWAA 4N5FA 1U8VA 2OEXA 4FF4A 1X90A 3EOMA 3M9VA 4J1VA 1SIRA 5K3HA 1JM6A 1OAHA 2F6LA 3LGQA 2CJ6A 3BNJA 1K93A 5GJWE 2IX6A 3TZ5A 2JBTA 2A1TA 2BU2A 4QICA 2DDHA 1K8TA 3MPIA 2FP1A 1SC5A 2YYJA 1UKWA 3S7WA 4L3XA 3CRKA 2RFQA 1SIQA 1X8ZA 1UDYA 5K3JA 1GU6A 2AZEA 2JBRA 4H7QA 4DOYA 3KMLA 4Q1OA 1EGCA 2CJ8A 4HKRA 1FS9A 4V25A 3TZ4A 5BRMA 3TORA 2RDZA 4Q5CA 1PI1A 4E01A 1Y0VA 3II9A 2Z1QA 3VKGA 3UBRA 3N0RA 3UU9A 3MXLA 2OJQA 4H85A 3C46A 2AO2A 3D6BA 1Y8OA 2BU7A 2EBFX 2OT4A 2CJ7A 2Q8IA 2OR0A 4AKHA 4O5MA 3D9EA 2Q8GA 2C0UA 1Y8PA 5B5VA 4AKGA 2IX5A 2ZAFA 2GBBA 4Q4UA 3FCJA 2XS1A 5EZ3A 3MKHA 4IV6A 4KSAA 4L38A 2VF1A 4RM7A 3MDEA 1XFWA 4X28C 1XFUA 4L3ZA 3MMOA 2R0MA 4KTOA 3TTBA 3DJLA 2YYKA 2ZKJA 1RJ1A 2CX9A 5K3GA 1EGDA 4Q5BA 3D9GA 3MPJA 1XG2B 4AKIA 2WBIA 1FS8A 3RKHA 3C2PA 1X91A 3TZ0A 4U83A 3SXQA 4IRNA 2YYIA 4H81A 2CJ4A 2BU6A 2OEVA 1R3BA 2REHA 3BNGA 4G5EA 4WJYA 1W07A 3D1IA 5B6BA 3Q23A 2J7AA 3AFFA 2ZDYA 2DVLA 2E81A 1S26A 5K3IA 4JIZA 3GM6A 1K90A 5J6AA 4V26A 3Q24A 3CE2A 3PFDA 1XFXA 2ZDXA 3X29A 4KSFA 3D2RA 4MP7A 3C3LA 3TZ2A 2LFWA 4FF3A 3BNHA 1PK0A 2E80A 4W9UA 2EC5A 1RJ4A 2PNRA 2R05A 2YYMA 3F29A 4LQSB 2Q8FA 4ZYJA 2E0AA 2JIFA 3SF6A 5J71A 2ZO5A 4XVXA 5B5WA 4FF2A 1IS2A 1RP3A 2RF7A 3CRLA 2R02A 2PG0A 4E02A 1XFVA 3VKHA 4X28A 2YYLA 3P4TA 1WS9A 3OWMA 5M4NA 5M4MA 1RX0A 2YGWA 1QDBA
chains in the Genus database with same CATH topology
3B96A 4Q0TA 2D29A 3D9DA 3BNFA 2EBAA 2R0NA 4L3YA 3GQTA 4JEKA 4ZXVA 1JQIA 1BUCA 4NXLA 3OIBA 3D9FA 3X0XA 1T9GA 3GNCA 3FO3A 3NF4A 2FONA 3L1TA 3R7KA 2UXWA 3MDDA 3SWOA 2JBSA 3EONA 3AFEA 4P13A 4L1FA 1FS7A 4M9AA 4KCFA 2C12A 1R2JA 3LG1A 4Q17A 4OO2A 4HR3A 3HWCA 1IVHA 2YYGA 2VR0A 2VIGA 3X0YA 1EGEA 3OWAA 4N5FA 1U8VA 3EOMA 3M9VA 1SIRA 5K3HA 1OAHA 3LGQA 3BNJA 2IX6A 2JBTA 2A1TA 2DDHA 3MPIA 2YYJA 3S7WA 1UKWA 4L3XA 2RFQA 1SIQA 3SCEA 1UDYA 5K3JA 1GU6A 4Q1OA 2JBRA 4DOYA 1EGCA 1FS9A 3TORA 2RDZA 4Q5CA 3II9A 2Z1QA 3UBRA 3UU9A 3MXLA 3D6BA 2OT4A 2OR0A 4O5MA 3D9EA 2C0UA 2IX5A 2ZAFA 4Q4UA 3FCJA 3MKHA 4IV6A 4L38A 4RM7A 3MDEA 4L3ZA 4X28C 3MMOA 2R0MA 4KTOA 3TTBA 2YYKA 2CX9A 5K3GA 1EGDA 4Q5BA 3D9GA 3MPJA 2WBIA 1FS8A 3RKHA 4U83A 3SXQA 4IRNA 2YYIA 3BNGA 2REHA 4G5EA 4WJYA 1W07A 3D1IA 2J7AA 3AFFA 2DVLA 2E81A 5K3IA 3GM6A 3PFDA 3BNHA 2E80A 4W9UA 2YYMA 3F29A 4ZYJA 2JIFA 3SF6A 2ZO5A 4XVXA 1IS2A 2RF7A 2PG0A 4X28A 2YYLA 3P4TA 1WS9A 3OWMA 1RX0A 1QDBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B96 A;  4Q0T A;  2D29 A;  3D9D A;  3BNF A;  2EBA A;  2R0N A;  4L3Y A;  3GQT A;  4JEK A;  4ZXV A;  1JQI A;  1BUC A;  4NXL A;  3OIB A;  3D9F A;  3X0X A;  1T9G A;  3GNC A;  3FO3 A;  3NF4 A;  2FON A;  3L1T A;  3R7K A;  2UXW A;  3MDD A;  3SWO A;  2JBS A;  3EON A;  3AFE A;  4P13 A;  4L1F A;  1FS7 A;  4M9A A;  4KCF A;  2C12 A;  1R2J A;  3LG1 A;  4Q17 A;  4OO2 A;  4HR3 A;  3HWC A;  1IVH A;  2YYG A;  2VR0 A;  2VIG A;  3X0Y A;  1EGE A;  3OWA A;  4N5F A;  1U8V A;  3EOM A;  3M9V A;  1SIR A;  5K3H A;  1OAH A;  3LGQ A;  3BNJ A;  2IX6 A;  2JBT A;  2A1T A;  2DDH A;  3MPI A;  2YYJ A;  3S7W A;  1UKW A;  4L3X A;  2RFQ A;  1SIQ A;  3SCE A;  1UDY A;  5K3J A;  1GU6 A;  4Q1O A;  2JBR A;  4DOY A;  1EGC A;  1FS9 A;  3TOR A;  2RDZ A;  4Q5C A;  3II9 A;  2Z1Q A;  3UBR A;  3UU9 A;  3MXL A;  3D6B A;  2OT4 A;  2OR0 A;  4O5M A;  3D9E A;  2C0U A;  2IX5 A;  2ZAF A;  4Q4U A;  3FCJ A;  3MKH A;  4IV6 A;  4L38 A;  4RM7 A;  3MDE A;  4L3Z A;  4X28 C;  3MMO A;  2R0M A;  4KTO A;  3TTB A;  2YYK A;  2CX9 A;  5K3G A;  1EGD A;  4Q5B A;  3D9G A;  3MPJ A;  2WBI A;  1FS8 A;  3RKH A;  4U83 A;  3SXQ A;  4IRN A;  2YYI A;  3BNG A;  2REH A;  4G5E A;  4WJY A;  1W07 A;  3D1I A;  2J7A A;  3AFF A;  2DVL A;  2E81 A;  5K3I A;  3GM6 A;  3PFD A;  3BNH A;  2E80 A;  4W9U A;  2YYM A;  3F29 A;  4ZYJ A;  2JIF A;  3SF6 A;  2ZO5 A;  4XVX A;  1IS2 A;  2RF7 A;  2PG0 A;  4X28 A;  2YYL A;  3P4T A;  1WS9 A;  3OWM A;  1RX0 A;  1QDB A; 
#chains in the Genus database with same CATH topology
 2Q8H A;  3B96 A;  4KS9 A;  4Q0T A;  2D29 A;  3D9D A;  3BNF A;  4JIO A;  4F0X A;  4G97 A;  2EBA A;  2R0N A;  2XS8 A;  4L3Y A;  4FF1 A;  3GQT A;  4JEK A;  4ZXV A;  1JQI A;  2PO4 A;  1GKZ A;  4AI6 A;  1BUC A;  4NXL A;  1GJV A;  4MPC A;  5BRK A;  5M4K A;  3OIB A;  3D9F A;  3X0X A;  3SCE A;  1T9G A;  3GNC A;  2BU5 A;  3NF4 A;  3FO3 A;  2BTZ A;  2FON A;  3L1T A;  3R7K A;  2UXW A;  3MDD A;  3SWO A;  4P79 A;  2JBS A;  2R03 A;  3EON A;  3AFE A;  2BU8 A;  2FP2 A;  4HKS A;  1SK6 A;  4P13 A;  4L1F A;  1FS7 A;  5GJV E;  4M9A A;  5M4P A;  4KCF A;  2EBH X;  2C12 A;  2HJN A;  3U33 A;  2QR4 A;  1R2J A;  3LG1 A;  1GKX A;  4Q17 A;  4OO2 A;  1XFZ A;  4HR3 A;  3VAD A;  4E00 A;  4MPE A;  4DZY A;  3HWC A;  4MP2 A;  2CJ5 A;  1Y8N A;  1IVH A;  3Q22 A;  1XFY A;  2XQR B;  2YYG A;  1LVC A;  2VIG A;  3X0Y A;  2VR0 A;  4FZ4 A;  4LQQ B;  4MPN A;  3Q0A A;  1EGE A;  3OWA A;  4N5F A;  1U8V A;  2OEX A;  4FF4 A;  1X90 A;  3EOM A;  3M9V A;  4J1V A;  1SIR A;  5K3H A;  1JM6 A;  1OAH A;  2F6L A;  3LGQ A;  2CJ6 A;  3BNJ A;  1K93 A;  5GJW E;  2IX6 A;  3TZ5 A;  2JBT A;  2A1T A;  2BU2 A;  4QIC A;  2DDH A;  1K8T A;  3MPI A;  2FP1 A;  1SC5 A;  2YYJ A;  1UKW A;  3S7W A;  4L3X A;  3CRK A;  2RFQ A;  1SIQ A;  1X8Z A;  1UDY A;  5K3J A;  1GU6 A;  2AZE A;  2JBR A;  4H7Q A;  4DOY A;  3KML A;  4Q1O A;  1EGC A;  2CJ8 A;  4HKR A;  1FS9 A;  4V25 A;  3TZ4 A;  5BRM A;  3TOR A;  2RDZ A;  4Q5C A;  1PI1 A;  4E01 A;  1Y0V A;  3II9 A;  2Z1Q A;  3VKG A;  3UBR A;  3N0R A;  3UU9 A;  3MXL A;  2OJQ A;  4H85 A;  3C46 A;  2AO2 A;  3D6B A;  1Y8O A;  2BU7 A;  2EBF X;  2OT4 A;  2CJ7 A;  2Q8I A;  2OR0 A;  4AKH A;  4O5M A;  3D9E A;  2Q8G A;  2C0U A;  1Y8P A;  5B5V A;  4AKG A;  2IX5 A;  2ZAF A;  2GBB A;  4Q4U A;  3FCJ A;  2XS1 A;  5EZ3 A;  3MKH A;  4IV6 A;  4KSA A;  4L38 A;  2VF1 A;  4RM7 A;  3MDE A;  1XFW A;  4X28 C;  1XFU A;  4L3Z A;  3MMO A;  2R0M A;  4KTO A;  3TTB A;  3DJL A;  2YYK A;  2ZKJ A;  1RJ1 A;  2CX9 A;  5K3G A;  1EGD A;  4Q5B A;  3D9G A;  3MPJ A;  1XG2 B;  4AKI A;  2WBI A;  1FS8 A;  3RKH A;  3C2P A;  1X91 A;  3TZ0 A;  4U83 A;  3SXQ A;  4IRN A;  2YYI A;  4H81 A;  2CJ4 A;  2BU6 A;  2OEV A;  1R3B A;  2REH A;  3BNG A;  4G5E A;  4WJY A;  1W07 A;  3D1I A;  5B6B A;  3Q23 A;  2J7A A;  3AFF A;  2ZDY A;  2DVL A;  2E81 A;  1S26 A;  5K3I A;  4JIZ A;  3GM6 A;  1K90 A;  5J6A A;  4V26 A;  3Q24 A;  3CE2 A;  3PFD A;  1XFX A;  2ZDX A;  3X29 A;  4KSF A;  3D2R A;  4MP7 A;  3C3L A;  3TZ2 A;  2LFW A;  4FF3 A;  3BNH A;  1PK0 A;  2E80 A;  4W9U A;  2EC5 A;  1RJ4 A;  2PNR A;  2R05 A;  2YYM A;  3F29 A;  4LQS B;  2Q8F A;  4ZYJ A;  2E0A A;  2JIF A;  3SF6 A;  5J71 A;  2ZO5 A;  4XVX A;  5B5W A;  4FF2 A;  1IS2 A;  1RP3 A;  2RF7 A;  3CRL A;  2R02 A;  2PG0 A;  4E02 A;  1XFV A;  3VKH A;  4X28 A;  2YYL A;  3P4T A;  1WS9 A;  3OWM A;  5M4N A;  5M4M A;  1RX0 A;  2YGW A;  1QDB A; 
#chains in the Genus database with same CATH homology
 3B96 A;  4Q0T A;  2D29 A;  3D9D A;  3BNF A;  2EBA A;  2R0N A;  4L3Y A;  3GQT A;  4JEK A;  4ZXV A;  1JQI A;  1BUC A;  4NXL A;  3OIB A;  3D9F A;  3X0X A;  1T9G A;  3GNC A;  3FO3 A;  3NF4 A;  2FON A;  3L1T A;  3R7K A;  2UXW A;  3MDD A;  3SWO A;  2JBS A;  3EON A;  3AFE A;  4P13 A;  4L1F A;  1FS7 A;  4M9A A;  4KCF A;  2C12 A;  1R2J A;  3LG1 A;  4Q17 A;  4OO2 A;  4HR3 A;  3HWC A;  1IVH A;  2YYG A;  2VR0 A;  2VIG A;  3X0Y A;  1EGE A;  3OWA A;  4N5F A;  1U8V A;  3EOM A;  3M9V A;  1SIR A;  5K3H A;  1OAH A;  3LGQ A;  3BNJ A;  2IX6 A;  2JBT A;  2A1T A;  2DDH A;  3MPI A;  2YYJ A;  3S7W A;  1UKW A;  4L3X A;  2RFQ A;  1SIQ A;  3SCE A;  1UDY A;  5K3J A;  1GU6 A;  4Q1O A;  2JBR A;  4DOY A;  1EGC A;  1FS9 A;  3TOR A;  2RDZ A;  4Q5C A;  3II9 A;  2Z1Q A;  3UBR A;  3UU9 A;  3MXL A;  3D6B A;  2OT4 A;  2OR0 A;  4O5M A;  3D9E A;  2C0U A;  2IX5 A;  2ZAF A;  4Q4U A;  3FCJ A;  3MKH A;  4IV6 A;  4L38 A;  4RM7 A;  3MDE A;  4L3Z A;  4X28 C;  3MMO A;  2R0M A;  4KTO A;  3TTB A;  2YYK A;  2CX9 A;  5K3G A;  1EGD A;  4Q5B A;  3D9G A;  3MPJ A;  2WBI A;  1FS8 A;  3RKH A;  4U83 A;  3SXQ A;  4IRN A;  2YYI A;  3BNG A;  2REH A;  4G5E A;  4WJY A;  1W07 A;  3D1I A;  2J7A A;  3AFF A;  2DVL A;  2E81 A;  5K3I A;  3GM6 A;  3PFD A;  3BNH A;  2E80 A;  4W9U A;  2YYM A;  3F29 A;  4ZYJ A;  2JIF A;  3SF6 A;  2ZO5 A;  4XVX A;  1IS2 A;  2RF7 A;  2PG0 A;  4X28 A;  2YYL A;  3P4T A;  1WS9 A;  3OWM A;  1RX0 A;  1QDB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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