1U8VA

Crystal structure of 4-hydroxybutyryl-coa dehydratase from clostridium aminobutyricum: radical catalysis involving a [4fe-4s] cluster and flavin
Total Genus 194
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
194
sequence length
490
structure length
490
Chain Sequence
MLMTAEQYIESLRKLNTRVYMFGEKIENWVDHPMIRPSINCVRMTYELAQDPQYADLMTTKSNLIGKTINRFANLHQSTDDLRKKVKMQRLLGQKTASCFQRCVGMDAFNAVFSTTYEIDQKYGTNYHKNFTEYLKYIQENDLIVDGAMTDPKGDRGLAPSAQKDPDLFLRIVEKREDGIVVRGAKAHQTGSINSHEHIIMPTIAMTEADKDYAVSFACPSDADGLFMIYGRQSCDTRKMEEGADIDLGNKQFGGQEALVVFDNVFIPNDRIFLCQEYDFAGMMVERFAGYHRQSYGGCKVGVGDVVIGAAALAADYNGAQKASHVKDKLIEMTHLNETLYCCGIACSAEGYPTAAGNYQIDLLLANVCKQNITRFPYEIVRLAEDIAGGLMVTMPSEADFKSETVVGRDGETIGDFCNKFFAAAPTCTTEERMRVLRFLENICLGASAVGYRTESMHGAGSPQAQRIMIARQGNINAKKELAKAIAGIK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase, isomerase
molecule keywords Gamma-aminobutyrate metabolism dehydratase/isomerase
publication title Crystal structure of 4-hydroxybutyryl-CoA dehydratase: radical catalysis involving a [4Fe-4S] cluster and flavin.
pubmed doi rcsb
total genus 194
structure length 490
sequence length 490
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.120: 4-hydroxybutanoyl-CoA dehydratase.
pdb deposition date 2004-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03241 HpaB 4-hydroxyphenylacetate 3-hydroxylase C terminal
A PF11794 HpaB_N 4-hydroxyphenylacetate 3-hydroxylase N terminal
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3140.10 Mainly Alpha Orthogonal Bundle 4-hydroxybutyryl-coa dehydratase, domain 1 4-hydroxybutyryl-coa dehydratase, domain 1 1u8vA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1u8vA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1u8vA02
3II9A 2UXWA 3UU9A 5K3IA 2JIFA 2REHA 2FONA 1FS9A 4HR3A 2YYGA 4IRNA 3OWAA 4ZYJA 2OT4A 3OWMA 2EBAA 3MXLA 2PG0A 1IS2A 3D6BA 4Q0TA 3FCJA 3BNFA 4U83A 3MKHA 3AFFA 3D9GA 3SWOA 3M9VA 2E80A 4XVXA 3TTBA 4L1FA 2RFQA 4M9AA 1UKWA 2JBSA 2IX6A 3D9FA 3MPIA 3EONA 3SCEA 2R0MA 2VR0A 1WS9A 1T9GA 2YYJA 4ZXVA 2R0NA 3L1TA 3PFDA 4W9UA 1EGEA 1IVHA 4L38A 3FO3A 1UDYA 3X0XA 4L3YA 3SF6A 4JEKA 2YYIA 3MDDA 3D9DA 2J7AA 1EGCA 2YYLA 2DDHA 4P13A 2VIGA 2YYKA 3RKHA 3TORA 2CX9A 2Z1QA 4IV6A 2DVLA 1U8VA 2RF7A 3BNJA 3F29A 3GQTA 4Q1OA 1W07A 2RDZA 3OIBA 4KCFA 5K3HA 1OAHA 3B96A 4Q17A 3R7KA 2JBRA 4Q4UA 2JBTA 1SIQA 4O5MA 1GU6A 3UBRA 2E81A 2ZO5A 5K3JA 2C12A 3NF4A 3LG1A 4WJYA 1BUCA 3MMOA 3HWCA 3S7WA 2D29A 3LGQA 1RX0A 4OO2A 4X28A 1JQIA 4DOYA 3D9EA 1EGDA 4X28C 2C0UA 3EOMA 3GM6A 2A1TA 3MDEA 3GNCA 1R2JA 5K3GA 2IX5A 2WBIA 1FS8A 3P4TA 3D1IA 4L3ZA 4NXLA 4Q5BA 3SXQA 4RM7A 2OR0A 4N5FA 3BNGA 1QDBA 1SIRA 4G5EA 2YYMA 4L3XA 3X0YA 4KTOA 2ZAFA 4Q5CA 1FS7A 3MPJA 3BNHA 3AFEA
chains in the Genus database with same CATH superfamily
3II9A 2UXWA 2Q8IA 3UU9A 5K3IA 2JIFA 2REHA 2FONA 1FS9A 2EBHX 2YYGA 4HR3A 1PK0A 4IRNA 5J6AA 2HJNA 3OWAA 2BU5A 4ZYJA 2OT4A 2OEVA 3OWMA 2BTZA 2EBAA 4HKSA 3MXLA 5B5WA 2PG0A 2FP2A 2ZKJA 5M4KA 1IS2A 4P79A 4AKGA 2BU6A 1XG2B 3D6BA 4Q0TA 4E01A 4DZYA 1X91A 3FCJA 3BNFA 4U83A 4MPNA 3MKHA 4HKRA 1K8TA 2AZEA 3AFFA 3D9GA 3SWOA 3M9VA 2E80A 3C3LA 4XVXA 3VKGA 4KS9A 3TTBA 1RJ4A 4L1FA 2BU2A 2Q8HA 2RFQA 4M9AA 1XFZA 3U33A 4JIZA 1UKWA 2JBSA 2IX6A 4V26A 3D9FA 3MPIA 4V25A 1GKZA 1JM6A 3EONA 4JIOA 3SCEA 2R0MA 1K90A 2VR0A 2ZDYA 1WS9A 1T9GA 2YYJA 3CRLA 4G97A 4ZXVA 3Q23A 2BU8A 2R0NA 3L1TA 3PFDA 4W9UA 1EGEA 3R7KA 5J71A 1IVHA 4L38A 5GJVE 4FF2A 3FO3A 1GJVA 1UDYA 3X0XA 3VKHA 3D2RA 1R3BA 4L3YA 3SF6A 4JEKA 4E00A 2YYIA 1Y0VA 2CJ6A 3MDDA 4F0XA 5M4PA 3D9DA 2J7AA 1EGCA 5K3HA 4AKHA 2YYLA 2DDHA 2LFWA 2XS8A 4P13A 4QICA 2VIGA 2YYKA 3RKHA 3TORA 4AI6A 2CX9A 2F6LA 2Z1QA 4IV6A 3TZ0A 2DVLA 1U8VA 2RF7A 3TZ5A 3BNJA 3F29A 3GQTA 1SK6A 4Q1OA 2CJ8A 1W07A 2RDZA 3OIBA 3CRKA 4KCFA 1SC5A 1OAHA 2E0AA 3B96A 4H85A 1RP3A 1Y8PA 2JBRA 2R02A 4MP2A 2XS1A 4Q4UA 1XFUA 2CJ7A 1SIQA 2JBTA 2ZDXA 4FZ4A 5B5VA 4Q17A 3Q24A 5M4NA 1XFVA 2Q8FA 3N0RA 1XFXA 4O5MA 2OEXA 1GU6A 3UBRA 1GKXA 2E81A 2ZO5A 5K3JA 2C12A 3Q0AA 3NF4A 3LG1A 2YGWA 4WJYA 1BUCA 2AO2A 3MMOA 4H81A 4KSAA 3C46A 3HWCA 3S7WA 2EC5A 3CE2A 2D29A 4H7QA 3LGQA 1Y8OA 1RX0A 5GJWE 4OO2A 4E02A 4X28A 4AKIA 2VF1A 5BRMA 4J1VA 2CJ5A 2QR4A 2PO4A 1JQIA 3KMLA 4MPEA 1K93A 4DOYA 3D9EA 1EGDA 1RJ1A 1S26A 2R05A 2PNRA 4X28C 2C0UA 1LVCA 3EOMA 3GM6A 2EBFX 2A1TA 5EZ3A 3MDEA 4MP7A 3GNCA 3VADA 4FF4A 3Q22A 1R2JA 5K3GA 2IX5A 3C2PA 2WBIA 2BU7A 1FS8A 3P4TA 3TZ2A 4FF1A 3D1IA 4L3ZA 2Q8GA 4NXLA 4Q5BA 2GBBA 3BNHA 2CJ4A 2FP1A 1PI1A 3SXQA 1Y8NA 1X90A 5BRKA 2R03A 4RM7A 2OR0A 3TZ4A 4KSFA 4N5FA 3BNGA 1QDBA 1SIRA 4FF3A 4G5EA 4MPCA 3X29A 2YYMA 2OJQA 4LQQB 4L3XA 3DJLA 3X0YA 4LQSB 4KTOA 2ZAFA 2XQRB 4Q5CA 1FS7A 5M4MA 1X8ZA 1XFYA 5B6BA 3MPJA 1XFWA 3AFEA
chains in the Genus database with same CATH topology
3II9A 2UXWA 3UU9A 5K3IA 2JIFA 2REHA 2FONA 1FS9A 4HR3A 2YYGA 4IRNA 3OWAA 4ZYJA 2OT4A 3OWMA 2EBAA 3MXLA 2PG0A 1IS2A 3D6BA 4Q0TA 3FCJA 3BNFA 4U83A 3MKHA 3AFFA 3D9GA 3SWOA 3M9VA 2E80A 4XVXA 3TTBA 4L1FA 2RFQA 4M9AA 1UKWA 2JBSA 2IX6A 3D9FA 3MPIA 3EONA 3SCEA 2R0MA 2VR0A 1WS9A 1T9GA 2YYJA 4ZXVA 2R0NA 3L1TA 3PFDA 4W9UA 1EGEA 1IVHA 4L38A 3FO3A 1UDYA 3X0XA 4L3YA 3SF6A 4JEKA 2YYIA 3MDDA 3D9DA 2J7AA 1EGCA 2YYLA 2DDHA 4P13A 2VIGA 2YYKA 3RKHA 3TORA 2CX9A 2Z1QA 4IV6A 2DVLA 1U8VA 2RF7A 3BNJA 3F29A 3GQTA 4Q1OA 1W07A 2RDZA 3OIBA 4KCFA 5K3HA 1OAHA 3B96A 4Q17A 3R7KA 2JBRA 4Q4UA 2JBTA 1SIQA 4O5MA 1GU6A 3UBRA 2E81A 2ZO5A 5K3JA 2C12A 3NF4A 3LG1A 4WJYA 1BUCA 3MMOA 3HWCA 3S7WA 2D29A 3LGQA 1RX0A 4OO2A 4X28A 1JQIA 4DOYA 3D9EA 1EGDA 4X28C 2C0UA 3EOMA 3GM6A 2A1TA 3MDEA 3GNCA 1R2JA 5K3GA 2IX5A 2WBIA 1FS8A 3P4TA 3D1IA 4L3ZA 4NXLA 4Q5BA 3SXQA 4RM7A 2OR0A 4N5FA 3BNGA 1QDBA 1SIRA 4G5EA 2YYMA 4L3XA 3X0YA 4KTOA 2ZAFA 4Q5CA 1FS7A 3MPJA 3BNHA 3AFEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3II9 A;  2UXW A;  3UU9 A;  5K3I A;  2JIF A;  2REH A;  2FON A;  1FS9 A;  4HR3 A;  2YYG A;  4IRN A;  3OWA A;  4ZYJ A;  2OT4 A;  3OWM A;  2EBA A;  3MXL A;  2PG0 A;  1IS2 A;  3D6B A;  4Q0T A;  3FCJ A;  3BNF A;  4U83 A;  3MKH A;  3AFF A;  3D9G A;  3SWO A;  3M9V A;  2E80 A;  4XVX A;  3TTB A;  4L1F A;  2RFQ A;  4M9A A;  1UKW A;  2JBS A;  2IX6 A;  3D9F A;  3MPI A;  3EON A;  3SCE A;  2R0M A;  2VR0 A;  1WS9 A;  1T9G A;  2YYJ A;  4ZXV A;  2R0N A;  3L1T A;  3PFD A;  4W9U A;  1EGE A;  1IVH A;  4L38 A;  3FO3 A;  1UDY A;  3X0X A;  4L3Y A;  3SF6 A;  4JEK A;  2YYI A;  3MDD A;  3D9D A;  2J7A A;  1EGC A;  2YYL A;  2DDH A;  4P13 A;  2VIG A;  2YYK A;  3RKH A;  3TOR A;  2CX9 A;  2Z1Q A;  4IV6 A;  2DVL A;  1U8V A;  2RF7 A;  3BNJ A;  3F29 A;  3GQT A;  4Q1O A;  1W07 A;  2RDZ A;  3OIB A;  4KCF A;  5K3H A;  1OAH A;  3B96 A;  4Q17 A;  3R7K A;  2JBR A;  4Q4U A;  2JBT A;  1SIQ A;  4O5M A;  1GU6 A;  3UBR A;  2E81 A;  2ZO5 A;  5K3J A;  2C12 A;  3NF4 A;  3LG1 A;  4WJY A;  1BUC A;  3MMO A;  3HWC A;  3S7W A;  2D29 A;  3LGQ A;  1RX0 A;  4OO2 A;  4X28 A;  1JQI A;  4DOY A;  3D9E A;  1EGD A;  4X28 C;  2C0U A;  3EOM A;  3GM6 A;  2A1T A;  3MDE A;  3GNC A;  1R2J A;  5K3G A;  2IX5 A;  2WBI A;  1FS8 A;  3P4T A;  3D1I A;  4L3Z A;  4NXL A;  4Q5B A;  3SXQ A;  4RM7 A;  2OR0 A;  4N5F A;  3BNG A;  1QDB A;  1SIR A;  4G5E A;  2YYM A;  4L3X A;  3X0Y A;  4KTO A;  2ZAF A;  4Q5C A;  1FS7 A;  3MPJ A;  3BNH A;  3AFE A; 
#chains in the Genus database with same CATH topology
 3II9 A;  2UXW A;  2Q8I A;  3UU9 A;  5K3I A;  2JIF A;  2REH A;  2FON A;  1FS9 A;  2EBH X;  2YYG A;  4HR3 A;  1PK0 A;  4IRN A;  5J6A A;  2HJN A;  3OWA A;  2BU5 A;  4ZYJ A;  2OT4 A;  2OEV A;  3OWM A;  2BTZ A;  2EBA A;  4HKS A;  3MXL A;  5B5W A;  2PG0 A;  2FP2 A;  2ZKJ A;  5M4K A;  1IS2 A;  4P79 A;  4AKG A;  2BU6 A;  1XG2 B;  3D6B A;  4Q0T A;  4E01 A;  4DZY A;  1X91 A;  3FCJ A;  3BNF A;  4U83 A;  4MPN A;  3MKH A;  4HKR A;  1K8T A;  2AZE A;  3AFF A;  3D9G A;  3SWO A;  3M9V A;  2E80 A;  3C3L A;  4XVX A;  3VKG A;  4KS9 A;  3TTB A;  1RJ4 A;  4L1F A;  2BU2 A;  2Q8H A;  2RFQ A;  4M9A A;  1XFZ A;  3U33 A;  4JIZ A;  1UKW A;  2JBS A;  2IX6 A;  4V26 A;  3D9F A;  3MPI A;  4V25 A;  1GKZ A;  1JM6 A;  3EON A;  4JIO A;  3SCE A;  2R0M A;  1K90 A;  2VR0 A;  2ZDY A;  1WS9 A;  1T9G A;  2YYJ A;  3CRL A;  4G97 A;  4ZXV A;  3Q23 A;  2BU8 A;  2R0N A;  3L1T A;  3PFD A;  4W9U A;  1EGE A;  3R7K A;  5J71 A;  1IVH A;  4L38 A;  5GJV E;  4FF2 A;  3FO3 A;  1GJV A;  1UDY A;  3X0X A;  3VKH A;  3D2R A;  1R3B A;  4L3Y A;  3SF6 A;  4JEK A;  4E00 A;  2YYI A;  1Y0V A;  2CJ6 A;  3MDD A;  4F0X A;  5M4P A;  3D9D A;  2J7A A;  1EGC A;  5K3H A;  4AKH A;  2YYL A;  2DDH A;  2LFW A;  2XS8 A;  4P13 A;  4QIC A;  2VIG A;  2YYK A;  3RKH A;  3TOR A;  4AI6 A;  2CX9 A;  2F6L A;  2Z1Q A;  4IV6 A;  3TZ0 A;  2DVL A;  1U8V A;  2RF7 A;  3TZ5 A;  3BNJ A;  3F29 A;  3GQT A;  1SK6 A;  4Q1O A;  2CJ8 A;  1W07 A;  2RDZ A;  3OIB A;  3CRK A;  4KCF A;  1SC5 A;  1OAH A;  2E0A A;  3B96 A;  4H85 A;  1RP3 A;  1Y8P A;  2JBR A;  2R02 A;  4MP2 A;  2XS1 A;  4Q4U A;  1XFU A;  2CJ7 A;  1SIQ A;  2JBT A;  2ZDX A;  4FZ4 A;  5B5V A;  4Q17 A;  3Q24 A;  5M4N A;  1XFV A;  2Q8F A;  3N0R A;  1XFX A;  4O5M A;  2OEX A;  1GU6 A;  3UBR A;  1GKX A;  2E81 A;  2ZO5 A;  5K3J A;  2C12 A;  3Q0A A;  3NF4 A;  3LG1 A;  2YGW A;  4WJY A;  1BUC A;  2AO2 A;  3MMO A;  4H81 A;  4KSA A;  3C46 A;  3HWC A;  3S7W A;  2EC5 A;  3CE2 A;  2D29 A;  4H7Q A;  3LGQ A;  1Y8O A;  1RX0 A;  5GJW E;  4OO2 A;  4E02 A;  4X28 A;  4AKI A;  2VF1 A;  5BRM A;  4J1V A;  2CJ5 A;  2QR4 A;  2PO4 A;  1JQI A;  3KML A;  4MPE A;  1K93 A;  4DOY A;  3D9E A;  1EGD A;  1RJ1 A;  1S26 A;  2R05 A;  2PNR A;  4X28 C;  2C0U A;  1LVC A;  3EOM A;  3GM6 A;  2EBF X;  2A1T A;  5EZ3 A;  3MDE A;  4MP7 A;  3GNC A;  3VAD A;  4FF4 A;  3Q22 A;  1R2J A;  5K3G A;  2IX5 A;  3C2P A;  2WBI A;  2BU7 A;  1FS8 A;  3P4T A;  3TZ2 A;  4FF1 A;  3D1I A;  4L3Z A;  2Q8G A;  4NXL A;  4Q5B A;  2GBB A;  3BNH A;  2CJ4 A;  2FP1 A;  1PI1 A;  3SXQ A;  1Y8N A;  1X90 A;  5BRK A;  2R03 A;  4RM7 A;  2OR0 A;  3TZ4 A;  4KSF A;  4N5F A;  3BNG A;  1QDB A;  1SIR A;  4FF3 A;  4G5E A;  4MPC A;  3X29 A;  2YYM A;  2OJQ A;  4LQQ B;  4L3X A;  3DJL A;  3X0Y A;  4LQS B;  4KTO A;  2ZAF A;  2XQR B;  4Q5C A;  1FS7 A;  5M4M A;  1X8Z A;  1XFY A;  5B6B A;  3MPJ A;  1XFW A;  3AFE A; 
#chains in the Genus database with same CATH homology
 3II9 A;  2UXW A;  3UU9 A;  5K3I A;  2JIF A;  2REH A;  2FON A;  1FS9 A;  4HR3 A;  2YYG A;  4IRN A;  3OWA A;  4ZYJ A;  2OT4 A;  3OWM A;  2EBA A;  3MXL A;  2PG0 A;  1IS2 A;  3D6B A;  4Q0T A;  3FCJ A;  3BNF A;  4U83 A;  3MKH A;  3AFF A;  3D9G A;  3SWO A;  3M9V A;  2E80 A;  4XVX A;  3TTB A;  4L1F A;  2RFQ A;  4M9A A;  1UKW A;  2JBS A;  2IX6 A;  3D9F A;  3MPI A;  3EON A;  3SCE A;  2R0M A;  2VR0 A;  1WS9 A;  1T9G A;  2YYJ A;  4ZXV A;  2R0N A;  3L1T A;  3PFD A;  4W9U A;  1EGE A;  1IVH A;  4L38 A;  3FO3 A;  1UDY A;  3X0X A;  4L3Y A;  3SF6 A;  4JEK A;  2YYI A;  3MDD A;  3D9D A;  2J7A A;  1EGC A;  2YYL A;  2DDH A;  4P13 A;  2VIG A;  2YYK A;  3RKH A;  3TOR A;  2CX9 A;  2Z1Q A;  4IV6 A;  2DVL A;  1U8V A;  2RF7 A;  3BNJ A;  3F29 A;  3GQT A;  4Q1O A;  1W07 A;  2RDZ A;  3OIB A;  4KCF A;  5K3H A;  1OAH A;  3B96 A;  4Q17 A;  3R7K A;  2JBR A;  4Q4U A;  2JBT A;  1SIQ A;  4O5M A;  1GU6 A;  3UBR A;  2E81 A;  2ZO5 A;  5K3J A;  2C12 A;  3NF4 A;  3LG1 A;  4WJY A;  1BUC A;  3MMO A;  3HWC A;  3S7W A;  2D29 A;  3LGQ A;  1RX0 A;  4OO2 A;  4X28 A;  1JQI A;  4DOY A;  3D9E A;  1EGD A;  4X28 C;  2C0U A;  3EOM A;  3GM6 A;  2A1T A;  3MDE A;  3GNC A;  1R2J A;  5K3G A;  2IX5 A;  2WBI A;  1FS8 A;  3P4T A;  3D1I A;  4L3Z A;  4NXL A;  4Q5B A;  3SXQ A;  4RM7 A;  2OR0 A;  4N5F A;  3BNG A;  1QDB A;  1SIR A;  4G5E A;  2YYM A;  4L3X A;  3X0Y A;  4KTO A;  2ZAF A;  4Q5C A;  1FS7 A;  3MPJ A;  3BNH A;  3AFE A; 
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similar chains in the Genus database (?% sequence similarity)
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