2YYMA

Crystal structure of the mutant of hpab (t198i, a276g, and r466h) complexed with fad and 4-hydroxyphenylacetate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
476
structure length
476
Chain Sequence
ARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTYEEEGKRHGMSFLIPKTKEDLKRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPDPYIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSILLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLSSRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYGATGALNHMAHQVVALKTAKTEAFLGVAALMAEGIGADVYGHVQEKIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFLEKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIHAFLKESLKVFE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords 4-hydroxyphenylacetate-3-hydroxylase
publication title Crystal Structure of the Oxygenase Component (HpaB) of the 4-Hydroxyphenylacetate 3-Monooxygenase from Thermus thermophilus HB8
pubmed doi rcsb
source organism Thermus thermophilus
total genus 179
structure length 476
sequence length 476
ec nomenclature ec 1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase.
pdb deposition date 2007-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03241 HpaB 4-hydroxyphenylacetate 3-hydroxylase C terminal
A PF11794 HpaB_N 4-hydroxyphenylacetate 3-hydroxylase N terminal
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3140.10 Mainly Alpha Orthogonal Bundle 4-hydroxybutyryl-coa dehydratase, domain 1 4-hydroxybutyryl-coa dehydratase, domain 1 2yymA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 2yymA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 2yymA02
1RX0A 2OR0A 4RM7A 2VIGA 4Q0TA 2WBIA 3MKHA 1EGCA 1SIQA 2R0NA 3BNFA 4Q1OA 3S7WA 3TTBA 4NXLA 4L3ZA 3MDEA 2REHA 2YYGA 1BUCA 2UXWA 4X28A 3SCEA 4X28C 2E81A 4O5MA 2OT4A 3HWCA 3LG1A 4HR3A 2A1TA 3BNGA 3SF6A 1UKWA 2JIFA 3D1IA 4OO2A 3TORA 4KCFA 2ZO5A 1FS7A 1SIRA 4P13A 3FCJA 3PFDA 4L3XA 4W9UA 1QDBA 2RFQA 3UU9A 3D9GA 3P4TA 3SXQA 2ZAFA 3BNJA 2DVLA 3D9DA 4IV6A 2D29A 2FONA 2RDZA 3X0YA 3AFFA 3F29A 3AFEA 1IVHA 3B96A 3MMOA 3M9VA 3OWMA 5K3IA 3RKHA 3L1TA 3MPIA 4ZXVA 3D6BA 4L3YA 2YYLA 1WS9A 2IX5A 4L1FA 3MPJA 4Q5BA 5K3GA 2E80A 4ZYJA 3GNCA 4M9AA 4JEKA 4L38A 4G5EA 2C12A 2J7AA 3MDDA 2EBAA 1T9GA 3GM6A 3D9EA 4U83A 4DOYA 2YYJA 1FS9A 2Z1QA 3SWOA 1GU6A 3II9A 3NF4A 4KTOA 2IX6A 3BNHA 2JBTA 3LGQA 4XVXA 5K3HA 1FS8A 3R7KA 4Q5CA 2PG0A 1IS2A 4N5FA 2RF7A 4IRNA 2C0UA 1OAHA 3OIBA 2VR0A 2YYKA 3EONA 4Q17A 5K3JA 2JBRA 2DDHA 1EGEA 4WJYA 2JBSA 3GQTA 3OWAA 1R2JA 1U8VA 1EGDA 2YYMA 2YYIA 3EOMA 1W07A 1JQIA 3UBRA 1UDYA 3D9FA 3X0XA 3MXLA 4Q4UA 3FO3A 2CX9A 2R0MA
chains in the Genus database with same CATH superfamily
1RX0A 2OR0A 4RM7A 4FF4A 2VIGA 4JIOA 2EBFX 4Q0TA 2WBIA 3MKHA 1EGCA 1SIQA 2R0NA 3BNFA 4Q1OA 3S7WA 3TTBA 4J1VA 4NXLA 3C46A 3DJLA 1PK0A 2R05A 4L3ZA 5M4KA 3MDEA 5BRKA 2LFWA 2REHA 1RJ1A 2YYGA 1BUCA 2AZEA 2UXWA 4MP2A 4X28A 1XFZA 2CJ7A 3SCEA 3N0RA 1PI1A 4X28C 2BU5A 2E81A 4O5MA 2OT4A 3TZ2A 3HWCA 3LG1A 4HR3A 1XFYA 2A1TA 2Q8FA 3BNGA 3SF6A 1UKWA 1K93A 3U33A 3C2PA 4G97A 2JIFA 3D1IA 4OO2A 4FF3A 2CJ5A 3TORA 4KCFA 2ZO5A 1FS7A 1SIRA 4KSFA 4P13A 3X29A 4E00A 5B6BA 2PNRA 1R3BA 4LQQB 2OEXA 1K90A 4KS9A 4MPCA 5GJWE 3FCJA 2R03A 3KMLA 3PFDA 4L3XA 2Q8HA 5B5WA 4AKGA 4W9UA 2BTZA 1QDBA 1JM6A 2RFQA 4FF1A 5BRMA 3UU9A 4DZYA 4F0XA 5EZ3A 4WJYA 3D9GA 3P4TA 3SXQA 2ZAFA 4QICA 3BNJA 2DVLA 3D9DA 2GBBA 2CJ8A 2BU8A 4IV6A 4V26A 2D29A 4JIZA 2FONA 2RDZA 3X0YA 3AFFA 3F29A 4V25A 3AFEA 5M4MA 1IVHA 3B96A 3MMOA 2CJ6A 3C3LA 1X8ZA 3M9VA 4AKIA 2R02A 1S26A 3OWMA 4E01A 5K3IA 3Q0AA 3RKHA 2EC5A 3L1TA 3MPIA 4ZXVA 3D6BA 4L3YA 1SK6A 1GJVA 3Q24A 1Y8OA 4HKRA 2YYLA 2ZKJA 1WS9A 2IX5A 4L1FA 2HJNA 3MPJA 4Q5BA 5K3GA 2E80A 4ZYJA 3GNCA 4M9AA 4JEKA 4L38A 4G5EA 4MPEA 2C12A 2OJQA 4E02A 4FF2A 4FZ4A 2J7AA 4MP7A 3MDDA 2EBAA 1T9GA 2XS1A 3GM6A 5GJVE 5M4PA 3D9EA 4U83A 2F6LA 4DOYA 2YYJA 1FS9A 2Z1QA 3SWOA 1Y0VA 1GU6A 3II9A 2CJ4A 4HKSA 3NF4A 3VADA 3VKHA 4KTOA 2IX6A 3BNHA 1LVCA 2JBTA 2XS8A 3LGQA 4XVXA 5K3HA 1FS8A 2AO2A 3CRKA 3R7KA 5J6AA 4Q5CA 2PG0A 1XG2B 1IS2A 4N5FA 2BU6A 3CRLA 5J71A 2RF7A 4IRNA 3Q23A 2C0UA 1SC5A 1OAHA 3OIBA 2VR0A 2YYKA 2FP1A 2ZDXA 3EONA 2ZDYA 5B5VA 4Q17A 1XFXA 2JBRA 5K3JA 2DDHA 1RP3A 5M4NA 4AKHA 1EGEA 4H81A 4H85A 4P79A 1Y8PA 1GKXA 2VF1A 2JBSA 1RJ4A 3GQTA 4MPNA 2Q8GA 2XQRB 3OWAA 1XFWA 1R2JA 1U8VA 1GKZA 1K8TA 2EBHX 1EGDA 4LQSB 2E0AA 2YYMA 2Q8IA 2YYIA 3EOMA 4KSAA 1W07A 4H7QA 3D2RA 1JQIA 2BU7A 3Q22A 3VKGA 4AI6A 3CE2A 1UDYA 1X90A 2PO4A 3D9FA 3TZ5A 3UBRA 3X0XA 3TZ4A 3MXLA 1X91A 1Y8NA 2OEVA 1XFVA 3FO3A 4Q4UA 2CX9A 2YGWA 2BU2A 2FP2A 2QR4A 2R0MA 3TZ0A 1XFUA
chains in the Genus database with same CATH topology
1RX0A 2OR0A 4RM7A 2VIGA 4Q0TA 2WBIA 3MKHA 1EGCA 1SIQA 2R0NA 3BNFA 4Q1OA 3S7WA 3TTBA 4NXLA 4L3ZA 3MDEA 2REHA 2YYGA 1BUCA 2UXWA 4X28A 3SCEA 4X28C 2E81A 4O5MA 2OT4A 3HWCA 3LG1A 4HR3A 2A1TA 3BNGA 3SF6A 1UKWA 2JIFA 3D1IA 4OO2A 3TORA 4KCFA 2ZO5A 1FS7A 1SIRA 4P13A 3FCJA 3PFDA 4L3XA 4W9UA 1QDBA 2RFQA 3UU9A 3D9GA 3P4TA 3SXQA 2ZAFA 3BNJA 2DVLA 3D9DA 4IV6A 2D29A 2FONA 2RDZA 3X0YA 3AFFA 3F29A 3AFEA 1IVHA 3B96A 3MMOA 3M9VA 3OWMA 5K3IA 3RKHA 3L1TA 3MPIA 4ZXVA 3D6BA 4L3YA 2YYLA 1WS9A 2IX5A 4L1FA 3MPJA 4Q5BA 5K3GA 2E80A 4ZYJA 3GNCA 4M9AA 4JEKA 4L38A 4G5EA 2C12A 2J7AA 3MDDA 2EBAA 1T9GA 3GM6A 3D9EA 4U83A 4DOYA 2YYJA 1FS9A 2Z1QA 3SWOA 1GU6A 3II9A 3NF4A 4KTOA 2IX6A 3BNHA 2JBTA 3LGQA 4XVXA 5K3HA 1FS8A 3R7KA 4Q5CA 2PG0A 1IS2A 4N5FA 2RF7A 4IRNA 2C0UA 1OAHA 3OIBA 2VR0A 2YYKA 3EONA 4Q17A 5K3JA 2JBRA 2DDHA 1EGEA 4WJYA 2JBSA 3GQTA 3OWAA 1R2JA 1U8VA 1EGDA 2YYMA 2YYIA 3EOMA 1W07A 1JQIA 3UBRA 1UDYA 3D9FA 3X0XA 3MXLA 4Q4UA 3FO3A 2CX9A 2R0MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RX0 A;  2OR0 A;  4RM7 A;  2VIG A;  4Q0T A;  2WBI A;  3MKH A;  1EGC A;  1SIQ A;  2R0N A;  3BNF A;  4Q1O A;  3S7W A;  3TTB A;  4NXL A;  4L3Z A;  3MDE A;  2REH A;  2YYG A;  1BUC A;  2UXW A;  4X28 A;  3SCE A;  4X28 C;  2E81 A;  4O5M A;  2OT4 A;  3HWC A;  3LG1 A;  4HR3 A;  2A1T A;  3BNG A;  3SF6 A;  1UKW A;  2JIF A;  3D1I A;  4OO2 A;  3TOR A;  4KCF A;  2ZO5 A;  1FS7 A;  1SIR A;  4P13 A;  3FCJ A;  3PFD A;  4L3X A;  4W9U A;  1QDB A;  2RFQ A;  3UU9 A;  3D9G A;  3P4T A;  3SXQ A;  2ZAF A;  3BNJ A;  2DVL A;  3D9D A;  4IV6 A;  2D29 A;  2FON A;  2RDZ A;  3X0Y A;  3AFF A;  3F29 A;  3AFE A;  1IVH A;  3B96 A;  3MMO A;  3M9V A;  3OWM A;  5K3I A;  3RKH A;  3L1T A;  3MPI A;  4ZXV A;  3D6B A;  4L3Y A;  2YYL A;  1WS9 A;  2IX5 A;  4L1F A;  3MPJ A;  4Q5B A;  5K3G A;  2E80 A;  4ZYJ A;  3GNC A;  4M9A A;  4JEK A;  4L38 A;  4G5E A;  2C12 A;  2J7A A;  3MDD A;  2EBA A;  1T9G A;  3GM6 A;  3D9E A;  4U83 A;  4DOY A;  2YYJ A;  1FS9 A;  2Z1Q A;  3SWO A;  1GU6 A;  3II9 A;  3NF4 A;  4KTO A;  2IX6 A;  3BNH A;  2JBT A;  3LGQ A;  4XVX A;  5K3H A;  1FS8 A;  3R7K A;  4Q5C A;  2PG0 A;  1IS2 A;  4N5F A;  2RF7 A;  4IRN A;  2C0U A;  1OAH A;  3OIB A;  2VR0 A;  2YYK A;  3EON A;  4Q17 A;  5K3J A;  2JBR A;  2DDH A;  1EGE A;  4WJY A;  2JBS A;  3GQT A;  3OWA A;  1R2J A;  1U8V A;  1EGD A;  2YYM A;  2YYI A;  3EOM A;  1W07 A;  1JQI A;  3UBR A;  1UDY A;  3D9F A;  3X0X A;  3MXL A;  4Q4U A;  3FO3 A;  2CX9 A;  2R0M A; 
#chains in the Genus database with same CATH topology
 1RX0 A;  2OR0 A;  4RM7 A;  4FF4 A;  2VIG A;  4JIO A;  2EBF X;  4Q0T A;  2WBI A;  3MKH A;  1EGC A;  1SIQ A;  2R0N A;  3BNF A;  4Q1O A;  3S7W A;  3TTB A;  4J1V A;  4NXL A;  3C46 A;  3DJL A;  1PK0 A;  2R05 A;  4L3Z A;  5M4K A;  3MDE A;  5BRK A;  2LFW A;  2REH A;  1RJ1 A;  2YYG A;  1BUC A;  2AZE A;  2UXW A;  4MP2 A;  4X28 A;  1XFZ A;  2CJ7 A;  3SCE A;  3N0R A;  1PI1 A;  4X28 C;  2BU5 A;  2E81 A;  4O5M A;  2OT4 A;  3TZ2 A;  3HWC A;  3LG1 A;  4HR3 A;  1XFY A;  2A1T A;  2Q8F A;  3BNG A;  3SF6 A;  1UKW A;  1K93 A;  3U33 A;  3C2P A;  4G97 A;  2JIF A;  3D1I A;  4OO2 A;  4FF3 A;  2CJ5 A;  3TOR A;  4KCF A;  2ZO5 A;  1FS7 A;  1SIR A;  4KSF A;  4P13 A;  3X29 A;  4E00 A;  5B6B A;  2PNR A;  1R3B A;  4LQQ B;  2OEX A;  1K90 A;  4KS9 A;  4MPC A;  5GJW E;  3FCJ A;  2R03 A;  3KML A;  3PFD A;  4L3X A;  2Q8H A;  5B5W A;  4AKG A;  4W9U A;  2BTZ A;  1QDB A;  1JM6 A;  2RFQ A;  4FF1 A;  5BRM A;  3UU9 A;  4DZY A;  4F0X A;  5EZ3 A;  4WJY A;  3D9G A;  3P4T A;  3SXQ A;  2ZAF A;  4QIC A;  3BNJ A;  2DVL A;  3D9D A;  2GBB A;  2CJ8 A;  2BU8 A;  4IV6 A;  4V26 A;  2D29 A;  4JIZ A;  2FON A;  2RDZ A;  3X0Y A;  3AFF A;  3F29 A;  4V25 A;  3AFE A;  5M4M A;  1IVH A;  3B96 A;  3MMO A;  2CJ6 A;  3C3L A;  1X8Z A;  3M9V A;  4AKI A;  2R02 A;  1S26 A;  3OWM A;  4E01 A;  5K3I A;  3Q0A A;  3RKH A;  2EC5 A;  3L1T A;  3MPI A;  4ZXV A;  3D6B A;  4L3Y A;  1SK6 A;  1GJV A;  3Q24 A;  1Y8O A;  4HKR A;  2YYL A;  2ZKJ A;  1WS9 A;  2IX5 A;  4L1F A;  2HJN A;  3MPJ A;  4Q5B A;  5K3G A;  2E80 A;  4ZYJ A;  3GNC A;  4M9A A;  4JEK A;  4L38 A;  4G5E A;  4MPE A;  2C12 A;  2OJQ A;  4E02 A;  4FF2 A;  4FZ4 A;  2J7A A;  4MP7 A;  3MDD A;  2EBA A;  1T9G A;  2XS1 A;  3GM6 A;  5GJV E;  5M4P A;  3D9E A;  4U83 A;  2F6L A;  4DOY A;  2YYJ A;  1FS9 A;  2Z1Q A;  3SWO A;  1Y0V A;  1GU6 A;  3II9 A;  2CJ4 A;  4HKS A;  3NF4 A;  3VAD A;  3VKH A;  4KTO A;  2IX6 A;  3BNH A;  1LVC A;  2JBT A;  2XS8 A;  3LGQ A;  4XVX A;  5K3H A;  1FS8 A;  2AO2 A;  3CRK A;  3R7K A;  5J6A A;  4Q5C A;  2PG0 A;  1XG2 B;  1IS2 A;  4N5F A;  2BU6 A;  3CRL A;  5J71 A;  2RF7 A;  4IRN A;  3Q23 A;  2C0U A;  1SC5 A;  1OAH A;  3OIB A;  2VR0 A;  2YYK A;  2FP1 A;  2ZDX A;  3EON A;  2ZDY A;  5B5V A;  4Q17 A;  1XFX A;  2JBR A;  5K3J A;  2DDH A;  1RP3 A;  5M4N A;  4AKH A;  1EGE A;  4H81 A;  4H85 A;  4P79 A;  1Y8P A;  1GKX A;  2VF1 A;  2JBS A;  1RJ4 A;  3GQT A;  4MPN A;  2Q8G A;  2XQR B;  3OWA A;  1XFW A;  1R2J A;  1U8V A;  1GKZ A;  1K8T A;  2EBH X;  1EGD A;  4LQS B;  2E0A A;  2YYM A;  2Q8I A;  2YYI A;  3EOM A;  4KSA A;  1W07 A;  4H7Q A;  3D2R A;  1JQI A;  2BU7 A;  3Q22 A;  3VKG A;  4AI6 A;  3CE2 A;  1UDY A;  1X90 A;  2PO4 A;  3D9F A;  3TZ5 A;  3UBR A;  3X0X A;  3TZ4 A;  3MXL A;  1X91 A;  1Y8N A;  2OEV A;  1XFV A;  3FO3 A;  4Q4U A;  2CX9 A;  2YGW A;  2BU2 A;  2FP2 A;  2QR4 A;  2R0M A;  3TZ0 A;  1XFU A; 
#chains in the Genus database with same CATH homology
 1RX0 A;  2OR0 A;  4RM7 A;  2VIG A;  4Q0T A;  2WBI A;  3MKH A;  1EGC A;  1SIQ A;  2R0N A;  3BNF A;  4Q1O A;  3S7W A;  3TTB A;  4NXL A;  4L3Z A;  3MDE A;  2REH A;  2YYG A;  1BUC A;  2UXW A;  4X28 A;  3SCE A;  4X28 C;  2E81 A;  4O5M A;  2OT4 A;  3HWC A;  3LG1 A;  4HR3 A;  2A1T A;  3BNG A;  3SF6 A;  1UKW A;  2JIF A;  3D1I A;  4OO2 A;  3TOR A;  4KCF A;  2ZO5 A;  1FS7 A;  1SIR A;  4P13 A;  3FCJ A;  3PFD A;  4L3X A;  4W9U A;  1QDB A;  2RFQ A;  3UU9 A;  3D9G A;  3P4T A;  3SXQ A;  2ZAF A;  3BNJ A;  2DVL A;  3D9D A;  4IV6 A;  2D29 A;  2FON A;  2RDZ A;  3X0Y A;  3AFF A;  3F29 A;  3AFE A;  1IVH A;  3B96 A;  3MMO A;  3M9V A;  3OWM A;  5K3I A;  3RKH A;  3L1T A;  3MPI A;  4ZXV A;  3D6B A;  4L3Y A;  2YYL A;  1WS9 A;  2IX5 A;  4L1F A;  3MPJ A;  4Q5B A;  5K3G A;  2E80 A;  4ZYJ A;  3GNC A;  4M9A A;  4JEK A;  4L38 A;  4G5E A;  2C12 A;  2J7A A;  3MDD A;  2EBA A;  1T9G A;  3GM6 A;  3D9E A;  4U83 A;  4DOY A;  2YYJ A;  1FS9 A;  2Z1Q A;  3SWO A;  1GU6 A;  3II9 A;  3NF4 A;  4KTO A;  2IX6 A;  3BNH A;  2JBT A;  3LGQ A;  4XVX A;  5K3H A;  1FS8 A;  3R7K A;  4Q5C A;  2PG0 A;  1IS2 A;  4N5F A;  2RF7 A;  4IRN A;  2C0U A;  1OAH A;  3OIB A;  2VR0 A;  2YYK A;  3EON A;  4Q17 A;  5K3J A;  2JBR A;  2DDH A;  1EGE A;  4WJY A;  2JBS A;  3GQT A;  3OWA A;  1R2J A;  1U8V A;  1EGD A;  2YYM A;  2YYI A;  3EOM A;  1W07 A;  1JQI A;  3UBR A;  1UDY A;  3D9F A;  3X0X A;  3MXL A;  4Q4U A;  3FO3 A;  2CX9 A;  2R0M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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