2YYMA

Crystal structure of the mutant of hpab (t198i, a276g, and r466h) complexed with fad and 4-hydroxyphenylacetate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
476
structure length
476
Chain Sequence
ARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTYEEEGKRHGMSFLIPKTKEDLKRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPDPYIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSILLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLSSRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYGATGALNHMAHQVVALKTAKTEAFLGVAALMAEGIGADVYGHVQEKIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFLEKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIHAFLKESLKVFE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords 4-hydroxyphenylacetate-3-hydroxylase
publication title Crystal Structure of the Oxygenase Component (HpaB) of the 4-Hydroxyphenylacetate 3-Monooxygenase from Thermus thermophilus HB8
pubmed doi rcsb
source organism Thermus thermophilus
molecule tags Oxidoreductase
total genus 179
structure length 476
sequence length 476
ec nomenclature ec 1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase.
pdb deposition date 2007-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03241 HpaB 4-hydroxyphenylacetate 3-hydroxylase C terminal
A PF11794 HpaB_N 4-hydroxyphenylacetate 3-hydroxylase N terminal
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3140.10 Mainly Alpha Orthogonal Bundle 4-hydroxybutyryl-coa dehydratase, domain 1 4-hydroxybutyryl-coa dehydratase, domain 1 2yymA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 2yymA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 2yymA02
3MXLA 5K3HA 3BNHA 4L38A 3FCJA 4ZYJA 3D9DA 3MPJA 3D9FA 2D29A 2ZO5A 1RX0A 3BNGA 4M9AA 3P4TA 1FS7A 2R0NA 1UDYA 3PFDA 3TTBA 4L1FA 1EGEA 4Q1OA 4RM7A 1T9GA 3L1TA 4HR3A 4N5FA 2E80A 3TORA 5K3JA 3D9GA 3II9A 3GM6A 4L3XA 3R7KA 2UXWA 4OO2A 3OIBA 3OWMA 2IX6A 1QDBA 3SF6A 2REHA 3GQTA 1FS9A 2YYLA 2OR0A 1EGDA 3D6BA 3HWCA 4JEKA 3D1IA 3EONA 4Q0TA 3X0YA 3F29A 2YYIA 2ZAFA 3LG1A 4KTOA 2DDHA 2CX9A 3X0XA 1SIRA 5K3GA 2YYKA 2JBRA 3AFEA 4IRNA 3UBRA 1IVHA 2YYGA 4L3YA 3D9EA 1SIQA 3RKHA 2RF7A 2RFQA 4IV6A 4Q5BA 3GNCA 2RDZA 3SCEA 2JBSA 2OT4A 1WS9A 2IX5A 2R0MA 2PG0A 2YYMA 1EGCA 1R2JA 2C0UA 1U8VA 2WBIA 1UKWA 1OAHA 4W9UA 2Z1QA 3FO3A 3OWAA 2EBAA 3SWOA 3M9VA 3BNJA 5K3IA 3LGQA 3MPIA 2JBTA 3NF4A 4P13A 3EOMA 2FONA 2J7AA 2A1TA 3UU9A 2JIFA 1FS8A 4Q4UA 1JQIA 2DVLA 4KCFA 3SXQA 2YYJA 3B96A 4NXLA 4X28A 4G5EA 4X28C 4XVXA 3BNFA 3S7WA 3MKHA 4O5MA 3MDEA 2E81A 1IS2A 3MMOA 1BUCA 2VR0A 4ZXVA 4DOYA 2C12A 3AFFA 3MDDA 4WJYA 1W07A 2VIGA 1GU6A 4U83A 4L3ZA 4Q5CA 4Q17A
chains in the Genus database with same CATH superfamily
3MXLA 5K3HA 3BNHA 4L38A 3FCJA 3VADA 4ZYJA 1X91A 4FF3A 4AKIA 1LVCA 1PK0A 3D9DA 3MPJA 3D9FA 2D29A 2ZO5A 2BU7A 1RX0A 1RP3A 3BNGA 4FZ4A 4M9AA 1K90A 1R3BA 1FS7A 2CJ6A 2R0NA 1UDYA 3P4TA 4DZYA 3PFDA 1GKZA 4L1FA 3TTBA 1EGEA 3DJLA 4Q1OA 4MPNA 4F0XA 4RM7A 3C46A 1T9GA 2BU8A 4H81A 3Q24A 3L1TA 4HR3A 4N5FA 2E80A 1K8TA 1XG2B 3TORA 2R05A 5K3JA 3D9GA 3II9A 3GM6A 3N0RA 4L3XA 1K93A 3R7KA 2UXWA 2ZDXA 2BTZA 4OO2A 4AKHA 3OIBA 1GKXA 3OWMA 2IX6A 1QDBA 3SF6A 2REHA 3GQTA 5J71A 1RJ1A 1FS9A 2YGWA 2GBBA 2YYLA 2OR0A 3KMLA 1EGDA 4JIZA 1GJVA 3D6BA 4E02A 2E0AA 2R03A 2XS1A 4FF1A 4AKGA 3HWCA 3VKHA 4JEKA 5J6AA 3D1IA 3EONA 4Q0TA 3TZ5A 3X0YA 3F29A 2YYIA 2ZAFA 3D2RA 3LG1A 4KTOA 2DDHA 4E01A 4LQSB 2CX9A 3TZ2A 2BU2A 2CJ8A 2XS8A 1SIRA 3X0XA 2OJQA 5K3GA 2YYKA 2JBRA 3AFEA 4IRNA 1JM6A 3UBRA 3CE2A 3U33A 1IVHA 1XFVA 4KS9A 2YYGA 4L3YA 3D9EA 1SIQA 4G97A 2RF7A 3RKHA 3Q22A 5B5WA 3CRLA 2RFQA 4H7QA 5GJWE 4IV6A 4Q5BA 2EBFX 2Q8IA 3GNCA 5GJVE 2AZEA 1XFXA 2RDZA 1PI1A 3SCEA 2JBSA 2OT4A 1WS9A 1XFZA 3TZ4A 4FF4A 2IX5A 2R0MA 2PG0A 4MPEA 2YYMA 2FP2A 1XFWA 1EGCA 1R2JA 2C0UA 2XQRB 1U8VA 2WBIA 1UKWA 1OAHA 2FP1A 4W9UA 2Z1QA 3Q23A 1X8ZA 2CJ7A 4LQQB 1SK6A 4HKRA 2BU5A 3FO3A 5M4PA 2VF1A 4KSAA 3TZ0A 3OWAA 2EBAA 3SWOA 3M9VA 3BNJA 1XFYA 4MP2A 5K3IA 3LGQA 4HKSA 3X29A 2CJ5A 3MPIA 5BRMA 2F6LA 2HJNA 4MPCA 2BU6A 2JBTA 5M4MA 3Q0AA 1Y8NA 3NF4A 4JIOA 4MP7A 4P13A 3EOMA 2FONA 2J7AA 2A1TA 3UU9A 1FS8A 2JIFA 2ZDYA 3CRKA 4Q4UA 4V25A 2Q8FA 1JQIA 4QICA 2DVLA 2ZKJA 1XFUA 4KCFA 4FF2A 5M4KA 3SXQA 2OEXA 2YYJA 3B96A 2EBHX 4NXLA 2CJ4A 4X28A 4G5EA 4X28C 1Y8PA 3BNFA 4XVXA 3S7WA 2OEVA 3MKHA 2AO2A 1Y8OA 4O5MA 4V26A 2EC5A 1RJ4A 4KSFA 2PO4A 1Y0VA 2E81A 3MDEA 4J1VA 1IS2A 5EZ3A 5BRKA 3MMOA 2Q8HA 3VKGA 1BUCA 4H85A 2Q8GA 2VR0A 4ZXVA 3C3LA 4DOYA 4AI6A 2C12A 2LFWA 4P79A 5B6BA 3AFFA 3MDDA 4WJYA 5B5VA 2QR4A 1W07A 2PNRA 2VIGA 1GU6A 4U83A 1S26A 2R02A 4L3ZA 4Q5CA 1SC5A 4E00A 4Q17A 5M4NA 1X90A 3C2PA
chains in the Genus database with same CATH topology
3MXLA 5K3HA 3BNHA 4L38A 3FCJA 4ZYJA 3D9DA 3MPJA 3D9FA 2D29A 2ZO5A 1RX0A 3BNGA 4M9AA 3P4TA 1FS7A 2R0NA 1UDYA 3PFDA 3TTBA 4L1FA 1EGEA 4Q1OA 4RM7A 1T9GA 3L1TA 4HR3A 4N5FA 2E80A 3TORA 5K3JA 3D9GA 3II9A 3GM6A 4L3XA 3R7KA 2UXWA 4OO2A 3OIBA 3OWMA 2IX6A 1QDBA 3SF6A 2REHA 3GQTA 1FS9A 2YYLA 2OR0A 1EGDA 3D6BA 3HWCA 4JEKA 3D1IA 3EONA 4Q0TA 3X0YA 3F29A 2YYIA 2ZAFA 3LG1A 4KTOA 2DDHA 2CX9A 3X0XA 1SIRA 5K3GA 2YYKA 2JBRA 3AFEA 4IRNA 3UBRA 1IVHA 2YYGA 4L3YA 3D9EA 1SIQA 3RKHA 2RF7A 2RFQA 4IV6A 4Q5BA 3GNCA 2RDZA 3SCEA 2JBSA 2OT4A 1WS9A 2IX5A 2R0MA 2PG0A 2YYMA 1EGCA 1R2JA 2C0UA 1U8VA 2WBIA 1UKWA 1OAHA 4W9UA 2Z1QA 3FO3A 3OWAA 2EBAA 3SWOA 3M9VA 3BNJA 5K3IA 3LGQA 3MPIA 2JBTA 3NF4A 4P13A 3EOMA 2FONA 2J7AA 2A1TA 3UU9A 2JIFA 1FS8A 4Q4UA 1JQIA 2DVLA 4KCFA 3SXQA 2YYJA 3B96A 4NXLA 4X28A 4G5EA 4X28C 4XVXA 3BNFA 3S7WA 3MKHA 4O5MA 3MDEA 2E81A 1IS2A 3MMOA 1BUCA 2VR0A 4ZXVA 4DOYA 2C12A 3AFFA 3MDDA 4WJYA 1W07A 2VIGA 1GU6A 4U83A 4L3ZA 4Q5CA 4Q17A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MXL A;  5K3H A;  3BNH A;  4L38 A;  3FCJ A;  4ZYJ A;  3D9D A;  3MPJ A;  3D9F A;  2D29 A;  2ZO5 A;  1RX0 A;  3BNG A;  4M9A A;  3P4T A;  1FS7 A;  2R0N A;  1UDY A;  3PFD A;  3TTB A;  4L1F A;  1EGE A;  4Q1O A;  4RM7 A;  1T9G A;  3L1T A;  4HR3 A;  4N5F A;  2E80 A;  3TOR A;  5K3J A;  3D9G A;  3II9 A;  3GM6 A;  4L3X A;  3R7K A;  2UXW A;  4OO2 A;  3OIB A;  3OWM A;  2IX6 A;  1QDB A;  3SF6 A;  2REH A;  3GQT A;  1FS9 A;  2YYL A;  2OR0 A;  1EGD A;  3D6B A;  3HWC A;  4JEK A;  3D1I A;  3EON A;  4Q0T A;  3X0Y A;  3F29 A;  2YYI A;  2ZAF A;  3LG1 A;  4KTO A;  2DDH A;  2CX9 A;  3X0X A;  1SIR A;  5K3G A;  2YYK A;  2JBR A;  3AFE A;  4IRN A;  3UBR A;  1IVH A;  2YYG A;  4L3Y A;  3D9E A;  1SIQ A;  3RKH A;  2RF7 A;  2RFQ A;  4IV6 A;  4Q5B A;  3GNC A;  2RDZ A;  3SCE A;  2JBS A;  2OT4 A;  1WS9 A;  2IX5 A;  2R0M A;  2PG0 A;  2YYM A;  1EGC A;  1R2J A;  2C0U A;  1U8V A;  2WBI A;  1UKW A;  1OAH A;  4W9U A;  2Z1Q A;  3FO3 A;  3OWA A;  2EBA A;  3SWO A;  3M9V A;  3BNJ A;  5K3I A;  3LGQ A;  3MPI A;  2JBT A;  3NF4 A;  4P13 A;  3EOM A;  2FON A;  2J7A A;  2A1T A;  3UU9 A;  2JIF A;  1FS8 A;  4Q4U A;  1JQI A;  2DVL A;  4KCF A;  3SXQ A;  2YYJ A;  3B96 A;  4NXL A;  4X28 A;  4G5E A;  4X28 C;  4XVX A;  3BNF A;  3S7W A;  3MKH A;  4O5M A;  3MDE A;  2E81 A;  1IS2 A;  3MMO A;  1BUC A;  2VR0 A;  4ZXV A;  4DOY A;  2C12 A;  3AFF A;  3MDD A;  4WJY A;  1W07 A;  2VIG A;  1GU6 A;  4U83 A;  4L3Z A;  4Q5C A;  4Q17 A; 
#chains in the Genus database with same CATH topology
 3MXL A;  5K3H A;  3BNH A;  4L38 A;  3FCJ A;  3VAD A;  4ZYJ A;  1X91 A;  4FF3 A;  4AKI A;  1LVC A;  1PK0 A;  3D9D A;  3MPJ A;  3D9F A;  2D29 A;  2ZO5 A;  2BU7 A;  1RX0 A;  1RP3 A;  3BNG A;  4FZ4 A;  4M9A A;  1K90 A;  1R3B A;  1FS7 A;  2CJ6 A;  2R0N A;  1UDY A;  3P4T A;  4DZY A;  3PFD A;  1GKZ A;  4L1F A;  3TTB A;  1EGE A;  3DJL A;  4Q1O A;  4MPN A;  4F0X A;  4RM7 A;  3C46 A;  1T9G A;  2BU8 A;  4H81 A;  3Q24 A;  3L1T A;  4HR3 A;  4N5F A;  2E80 A;  1K8T A;  1XG2 B;  3TOR A;  2R05 A;  5K3J A;  3D9G A;  3II9 A;  3GM6 A;  3N0R A;  4L3X A;  1K93 A;  3R7K A;  2UXW A;  2ZDX A;  2BTZ A;  4OO2 A;  4AKH A;  3OIB A;  1GKX A;  3OWM A;  2IX6 A;  1QDB A;  3SF6 A;  2REH A;  3GQT A;  5J71 A;  1RJ1 A;  1FS9 A;  2YGW A;  2GBB A;  2YYL A;  2OR0 A;  3KML A;  1EGD A;  4JIZ A;  1GJV A;  3D6B A;  4E02 A;  2E0A A;  2R03 A;  2XS1 A;  4FF1 A;  4AKG A;  3HWC A;  3VKH A;  4JEK A;  5J6A A;  3D1I A;  3EON A;  4Q0T A;  3TZ5 A;  3X0Y A;  3F29 A;  2YYI A;  2ZAF A;  3D2R A;  3LG1 A;  4KTO A;  2DDH A;  4E01 A;  4LQS B;  2CX9 A;  3TZ2 A;  2BU2 A;  2CJ8 A;  2XS8 A;  1SIR A;  3X0X A;  2OJQ A;  5K3G A;  2YYK A;  2JBR A;  3AFE A;  4IRN A;  1JM6 A;  3UBR A;  3CE2 A;  3U33 A;  1IVH A;  1XFV A;  4KS9 A;  2YYG A;  4L3Y A;  3D9E A;  1SIQ A;  4G97 A;  2RF7 A;  3RKH A;  3Q22 A;  5B5W A;  3CRL A;  2RFQ A;  4H7Q A;  5GJW E;  4IV6 A;  4Q5B A;  2EBF X;  2Q8I A;  3GNC A;  5GJV E;  2AZE A;  1XFX A;  2RDZ A;  1PI1 A;  3SCE A;  2JBS A;  2OT4 A;  1WS9 A;  1XFZ A;  3TZ4 A;  4FF4 A;  2IX5 A;  2R0M A;  2PG0 A;  4MPE A;  2YYM A;  2FP2 A;  1XFW A;  1EGC A;  1R2J A;  2C0U A;  2XQR B;  1U8V A;  2WBI A;  1UKW A;  1OAH A;  2FP1 A;  4W9U A;  2Z1Q A;  3Q23 A;  1X8Z A;  2CJ7 A;  4LQQ B;  1SK6 A;  4HKR A;  2BU5 A;  3FO3 A;  5M4P A;  2VF1 A;  4KSA A;  3TZ0 A;  3OWA A;  2EBA A;  3SWO A;  3M9V A;  3BNJ A;  1XFY A;  4MP2 A;  5K3I A;  3LGQ A;  4HKS A;  3X29 A;  2CJ5 A;  3MPI A;  5BRM A;  2F6L A;  2HJN A;  4MPC A;  2BU6 A;  2JBT A;  5M4M A;  3Q0A A;  1Y8N A;  3NF4 A;  4JIO A;  4MP7 A;  4P13 A;  3EOM A;  2FON A;  2J7A A;  2A1T A;  3UU9 A;  1FS8 A;  2JIF A;  2ZDY A;  3CRK A;  4Q4U A;  4V25 A;  2Q8F A;  1JQI A;  4QIC A;  2DVL A;  2ZKJ A;  1XFU A;  4KCF A;  4FF2 A;  5M4K A;  3SXQ A;  2OEX A;  2YYJ A;  3B96 A;  2EBH X;  4NXL A;  2CJ4 A;  4X28 A;  4G5E A;  4X28 C;  1Y8P A;  3BNF A;  4XVX A;  3S7W A;  2OEV A;  3MKH A;  2AO2 A;  1Y8O A;  4O5M A;  4V26 A;  2EC5 A;  1RJ4 A;  4KSF A;  2PO4 A;  1Y0V A;  2E81 A;  3MDE A;  4J1V A;  1IS2 A;  5EZ3 A;  5BRK A;  3MMO A;  2Q8H A;  3VKG A;  1BUC A;  4H85 A;  2Q8G A;  2VR0 A;  4ZXV A;  3C3L A;  4DOY A;  4AI6 A;  2C12 A;  2LFW A;  4P79 A;  5B6B A;  3AFF A;  3MDD A;  4WJY A;  5B5V A;  2QR4 A;  1W07 A;  2PNR A;  2VIG A;  1GU6 A;  4U83 A;  1S26 A;  2R02 A;  4L3Z A;  4Q5C A;  1SC5 A;  4E00 A;  4Q17 A;  5M4N A;  1X90 A;  3C2P A; 
#chains in the Genus database with same CATH homology
 3MXL A;  5K3H A;  3BNH A;  4L38 A;  3FCJ A;  4ZYJ A;  3D9D A;  3MPJ A;  3D9F A;  2D29 A;  2ZO5 A;  1RX0 A;  3BNG A;  4M9A A;  3P4T A;  1FS7 A;  2R0N A;  1UDY A;  3PFD A;  3TTB A;  4L1F A;  1EGE A;  4Q1O A;  4RM7 A;  1T9G A;  3L1T A;  4HR3 A;  4N5F A;  2E80 A;  3TOR A;  5K3J A;  3D9G A;  3II9 A;  3GM6 A;  4L3X A;  3R7K A;  2UXW A;  4OO2 A;  3OIB A;  3OWM A;  2IX6 A;  1QDB A;  3SF6 A;  2REH A;  3GQT A;  1FS9 A;  2YYL A;  2OR0 A;  1EGD A;  3D6B A;  3HWC A;  4JEK A;  3D1I A;  3EON A;  4Q0T A;  3X0Y A;  3F29 A;  2YYI A;  2ZAF A;  3LG1 A;  4KTO A;  2DDH A;  2CX9 A;  3X0X A;  1SIR A;  5K3G A;  2YYK A;  2JBR A;  3AFE A;  4IRN A;  3UBR A;  1IVH A;  2YYG A;  4L3Y A;  3D9E A;  1SIQ A;  3RKH A;  2RF7 A;  2RFQ A;  4IV6 A;  4Q5B A;  3GNC A;  2RDZ A;  3SCE A;  2JBS A;  2OT4 A;  1WS9 A;  2IX5 A;  2R0M A;  2PG0 A;  2YYM A;  1EGC A;  1R2J A;  2C0U A;  1U8V A;  2WBI A;  1UKW A;  1OAH A;  4W9U A;  2Z1Q A;  3FO3 A;  3OWA A;  2EBA A;  3SWO A;  3M9V A;  3BNJ A;  5K3I A;  3LGQ A;  3MPI A;  2JBT A;  3NF4 A;  4P13 A;  3EOM A;  2FON A;  2J7A A;  2A1T A;  3UU9 A;  2JIF A;  1FS8 A;  4Q4U A;  1JQI A;  2DVL A;  4KCF A;  3SXQ A;  2YYJ A;  3B96 A;  4NXL A;  4X28 A;  4G5E A;  4X28 C;  4XVX A;  3BNF A;  3S7W A;  3MKH A;  4O5M A;  3MDE A;  2E81 A;  1IS2 A;  3MMO A;  1BUC A;  2VR0 A;  4ZXV A;  4DOY A;  2C12 A;  3AFF A;  3MDD A;  4WJY A;  1W07 A;  2VIG A;  1GU6 A;  4U83 A;  4L3Z A;  4Q5C A;  4Q17 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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