1SIRA

The crystal structure and mechanism of human glutaryl-coa dehydrogenase
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
390
structure length
390
Chain Sequence
EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutaryl-CoA dehydrogenase
publication title Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions
pubmed doi rcsb
molecule tags Oxidoreductase
total genus 151
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2004-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1sirA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1sirA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1sirA02
3BNHA 4IV6A 3F29A 2PG0A 1FS8A 3MKHA 1RX0A 4M9AA 4RM7A 2JBTA 1FS9A 4Q0TA 3GM6A 2EBAA 5K3HA 1SIRA 3M9VA 2VR0A 1UKWA 2YYGA 2R0MA 4X28C 2YYKA 4L3YA 2DDHA 1JQIA 3L1TA 2FONA 3D9EA 3X0YA 3B96A 3SWOA 1EGEA 3EOMA 4ZYJA 3BNFA 4HR3A 1IVHA 2UXWA 3D1IA 3FCJA 2OR0A 2CX9A 4DOYA 4W9UA 3S7WA 2ZAFA 1R2JA 2J7AA 1UDYA 4Q5CA 4ZXVA 2RF7A 4NXLA 4O5MA 3HWCA 4X28A 1SIQA 3SCEA 3EONA 3LGQA 2R0NA 3PFDA 1OAHA 2JBSA 5K3JA 3TORA 3R7KA 4KTOA 4KCFA 3OWAA 5K3GA 2OT4A 5K3IA 3MDDA 2REHA 1EGDA 1BUCA 4L38A 2JIFA 3SF6A 2JBRA 3UBRA 3MPJA 3OIBA 3BNJA 4L1FA 3OWMA 3II9A 4L3ZA 4Q17A 2A1TA 3AFFA 3D9DA 3LG1A 3P4TA 2ZO5A 4L3XA 2D29A 4G5EA 2WBIA 4Q1OA 3SXQA 2C12A 2VIGA 2Z1QA 1W07A 1WS9A 3FO3A 2YYJA 3GNCA 3D9GA 2E81A 3TTBA 4IRNA 3D9FA 1IS2A 1EGCA 2RFQA 2YYLA 4N5FA 3X0XA 4Q5BA 3RKHA 2DVLA 3GQTA 3AFEA 3MPIA 4JEKA 3BNGA 3NF4A 1FS7A 4WJYA 2E80A 3D6BA 2IX5A 2YYIA 1QDBA 2C0UA 1GU6A 1T9GA 3MMOA 2YYMA 2RDZA 4XVXA 4P13A 1U8VA 3MXLA 2IX6A 4Q4UA 4OO2A 3MDEA 4U83A 3UU9A
chains in the Genus database with same CATH superfamily
4H85A 3BNHA 4IV6A 3F29A 2PG0A 1FS8A 2EC5A 2PNRA 3MKHA 4KS9A 3CRLA 1K93A 1RX0A 4M9AA 4RM7A 2JBTA 2EBFX 4E02A 1FS9A 5M4PA 5GJVE 4Q0TA 3Q23A 2FP2A 3GM6A 2EBAA 5K3HA 1S26A 1SIRA 3M9VA 2E0AA 1RJ4A 2VR0A 1UKWA 1XFZA 4V26A 2YYGA 5J6AA 2R0MA 4X28C 4FZ4A 2YYKA 2F6LA 2DDHA 4H7QA 4L3YA 2ZKJA 1JQIA 3L1TA 2FONA 3D9EA 1SK6A 2PO4A 3X0YA 3B96A 3SWOA 4AI6A 1EGEA 2R05A 3EOMA 4LQQB 1RP3A 4DZYA 4ZYJA 2CJ4A 3BNFA 2Q8HA 4HR3A 3DJLA 5B5VA 1IVHA 2UXWA 3D1IA 3FCJA 2Q8FA 2OR0A 2BU6A 2CX9A 4HKSA 1XFWA 1X90A 4DOYA 1X91A 1XFVA 2BU7A 4W9UA 5BRKA 5M4MA 4AKGA 3S7WA 2ZAFA 1GKXA 1R2JA 2J7AA 2AO2A 1UDYA 4Q5CA 4P79A 4ZXVA 2RF7A 4NXLA 4O5MA 2CJ5A 1XG2B 2ZDYA 2FP1A 3HWCA 1PK0A 4X28A 4FF2A 4JIOA 2YGWA 1SIQA 3Q0AA 1GJVA 3SCEA 1K8TA 3VKGA 3EONA 2BU8A 3LGQA 2R0NA 3PFDA 4QICA 2Q8IA 1OAHA 2JBSA 1RJ1A 4MP2A 5K3JA 3TORA 1X8ZA 2BTZA 3R7KA 2GBBA 2EBHX 4KTOA 3D2RA 4KCFA 4AKIA 4AKHA 1LVCA 3OWAA 5K3GA 1Y8NA 2OT4A 3VKHA 5K3IA 2OEVA 2XS8A 3MDDA 2REHA 4G97A 4MP7A 3Q24A 1EGDA 1BUCA 4L38A 2JIFA 1GKZA 3SF6A 4MPCA 4MPEA 2JBRA 2BU2A 4FF4A 2CJ8A 3UBRA 2R02A 2QR4A 3MPJA 3OIBA 3BNJA 4L1FA 3N0RA 1Y8PA 3TZ5A 3TZ2A 4FF1A 3OWMA 1PI1A 3CRKA 3II9A 4L3ZA 4FF3A 4KSFA 4Q17A 2A1TA 3AFFA 4LQSB 3D9DA 2HJNA 3LG1A 4V25A 3P4TA 2ZO5A 3VADA 3X29A 4L3XA 2D29A 2BU5A 4G5EA 2WBIA 1XFXA 2R03A 4Q1OA 3SXQA 2C12A 2VIGA 2Z1QA 1W07A 1WS9A 3FO3A 2YYJA 4E01A 3GNCA 2XS1A 3D9GA 3C46A 2AZEA 2E81A 3TTBA 4IRNA 3D9FA 4E00A 1IS2A 1EGCA 1SC5A 2XQRB 2VF1A 2RFQA 1Y0VA 2YYLA 3U33A 3TZ4A 3C3LA 3CE2A 4H81A 2OEXA 4N5FA 3X0XA 4F0XA 2ZDXA 4Q5BA 3RKHA 2DVLA 3GQTA 3AFEA 5BRMA 3MPIA 1XFUA 2CJ6A 5GJWE 4JEKA 3BNGA 5M4KA 5EZ3A 3NF4A 4HKRA 4MPNA 1FS7A 4WJYA 1JM6A 2E80A 3D6BA 3KMLA 4KSAA 1Y8OA 3TZ0A 5J71A 2LFWA 2IX5A 2YYIA 1QDBA 2C0UA 2CJ7A 1GU6A 4J1VA 4JIZA 1T9GA 3MMOA 1XFYA 2YYMA 2RDZA 2Q8GA 3Q22A 3C2PA 2OJQA 4XVXA 5B5WA 4P13A 1U8VA 3MXLA 5B6BA 1R3BA 2IX6A 4Q4UA 1K90A 4OO2A 3MDEA 5M4NA 4U83A 3UU9A
chains in the Genus database with same CATH topology
3BNHA 4IV6A 3F29A 2PG0A 1FS8A 3MKHA 1RX0A 4M9AA 4RM7A 2JBTA 1FS9A 4Q0TA 3GM6A 2EBAA 5K3HA 1SIRA 3M9VA 2VR0A 1UKWA 2YYGA 2R0MA 4X28C 2YYKA 4L3YA 2DDHA 1JQIA 3L1TA 2FONA 3D9EA 3X0YA 3B96A 3SWOA 1EGEA 3EOMA 4ZYJA 3BNFA 4HR3A 1IVHA 2UXWA 3D1IA 3FCJA 2OR0A 2CX9A 4DOYA 4W9UA 3S7WA 2ZAFA 1R2JA 2J7AA 1UDYA 4Q5CA 4ZXVA 2RF7A 4NXLA 4O5MA 3HWCA 4X28A 1SIQA 3SCEA 3EONA 3LGQA 2R0NA 3PFDA 1OAHA 2JBSA 5K3JA 3TORA 3R7KA 4KTOA 4KCFA 3OWAA 5K3GA 2OT4A 5K3IA 3MDDA 2REHA 1EGDA 1BUCA 4L38A 2JIFA 3SF6A 2JBRA 3UBRA 3MPJA 3OIBA 3BNJA 4L1FA 3OWMA 3II9A 4L3ZA 4Q17A 2A1TA 3AFFA 3D9DA 3LG1A 3P4TA 2ZO5A 4L3XA 2D29A 4G5EA 2WBIA 4Q1OA 3SXQA 2C12A 2VIGA 2Z1QA 1W07A 1WS9A 3FO3A 2YYJA 3GNCA 3D9GA 2E81A 3TTBA 4IRNA 3D9FA 1IS2A 1EGCA 2RFQA 2YYLA 4N5FA 3X0XA 4Q5BA 3RKHA 2DVLA 3GQTA 3AFEA 3MPIA 4JEKA 3BNGA 3NF4A 1FS7A 4WJYA 2E80A 3D6BA 2IX5A 2YYIA 1QDBA 2C0UA 1GU6A 1T9GA 3MMOA 2YYMA 2RDZA 4XVXA 4P13A 1U8VA 3MXLA 2IX6A 4Q4UA 4OO2A 3MDEA 4U83A 3UU9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BNH A;  4IV6 A;  3F29 A;  2PG0 A;  1FS8 A;  3MKH A;  1RX0 A;  4M9A A;  4RM7 A;  2JBT A;  1FS9 A;  4Q0T A;  3GM6 A;  2EBA A;  5K3H A;  1SIR A;  3M9V A;  2VR0 A;  1UKW A;  2YYG A;  2R0M A;  4X28 C;  2YYK A;  4L3Y A;  2DDH A;  1JQI A;  3L1T A;  2FON A;  3D9E A;  3X0Y A;  3B96 A;  3SWO A;  1EGE A;  3EOM A;  4ZYJ A;  3BNF A;  4HR3 A;  1IVH A;  2UXW A;  3D1I A;  3FCJ A;  2OR0 A;  2CX9 A;  4DOY A;  4W9U A;  3S7W A;  2ZAF A;  1R2J A;  2J7A A;  1UDY A;  4Q5C A;  4ZXV A;  2RF7 A;  4NXL A;  4O5M A;  3HWC A;  4X28 A;  1SIQ A;  3SCE A;  3EON A;  3LGQ A;  2R0N A;  3PFD A;  1OAH A;  2JBS A;  5K3J A;  3TOR A;  3R7K A;  4KTO A;  4KCF A;  3OWA A;  5K3G A;  2OT4 A;  5K3I A;  3MDD A;  2REH A;  1EGD A;  1BUC A;  4L38 A;  2JIF A;  3SF6 A;  2JBR A;  3UBR A;  3MPJ A;  3OIB A;  3BNJ A;  4L1F A;  3OWM A;  3II9 A;  4L3Z A;  4Q17 A;  2A1T A;  3AFF A;  3D9D A;  3LG1 A;  3P4T A;  2ZO5 A;  4L3X A;  2D29 A;  4G5E A;  2WBI A;  4Q1O A;  3SXQ A;  2C12 A;  2VIG A;  2Z1Q A;  1W07 A;  1WS9 A;  3FO3 A;  2YYJ A;  3GNC A;  3D9G A;  2E81 A;  3TTB A;  4IRN A;  3D9F A;  1IS2 A;  1EGC A;  2RFQ A;  2YYL A;  4N5F A;  3X0X A;  4Q5B A;  3RKH A;  2DVL A;  3GQT A;  3AFE A;  3MPI A;  4JEK A;  3BNG A;  3NF4 A;  1FS7 A;  4WJY A;  2E80 A;  3D6B A;  2IX5 A;  2YYI A;  1QDB A;  2C0U A;  1GU6 A;  1T9G A;  3MMO A;  2YYM A;  2RDZ A;  4XVX A;  4P13 A;  1U8V A;  3MXL A;  2IX6 A;  4Q4U A;  4OO2 A;  3MDE A;  4U83 A;  3UU9 A; 
#chains in the Genus database with same CATH topology
 4H85 A;  3BNH A;  4IV6 A;  3F29 A;  2PG0 A;  1FS8 A;  2EC5 A;  2PNR A;  3MKH A;  4KS9 A;  3CRL A;  1K93 A;  1RX0 A;  4M9A A;  4RM7 A;  2JBT A;  2EBF X;  4E02 A;  1FS9 A;  5M4P A;  5GJV E;  4Q0T A;  3Q23 A;  2FP2 A;  3GM6 A;  2EBA A;  5K3H A;  1S26 A;  1SIR A;  3M9V A;  2E0A A;  1RJ4 A;  2VR0 A;  1UKW A;  1XFZ A;  4V26 A;  2YYG A;  5J6A A;  2R0M A;  4X28 C;  4FZ4 A;  2YYK A;  2F6L A;  2DDH A;  4H7Q A;  4L3Y A;  2ZKJ A;  1JQI A;  3L1T A;  2FON A;  3D9E A;  1SK6 A;  2PO4 A;  3X0Y A;  3B96 A;  3SWO A;  4AI6 A;  1EGE A;  2R05 A;  3EOM A;  4LQQ B;  1RP3 A;  4DZY A;  4ZYJ A;  2CJ4 A;  3BNF A;  2Q8H A;  4HR3 A;  3DJL A;  5B5V A;  1IVH A;  2UXW A;  3D1I A;  3FCJ A;  2Q8F A;  2OR0 A;  2BU6 A;  2CX9 A;  4HKS A;  1XFW A;  1X90 A;  4DOY A;  1X91 A;  1XFV A;  2BU7 A;  4W9U A;  5BRK A;  5M4M A;  4AKG A;  3S7W A;  2ZAF A;  1GKX A;  1R2J A;  2J7A A;  2AO2 A;  1UDY A;  4Q5C A;  4P79 A;  4ZXV A;  2RF7 A;  4NXL A;  4O5M A;  2CJ5 A;  1XG2 B;  2ZDY A;  2FP1 A;  3HWC A;  1PK0 A;  4X28 A;  4FF2 A;  4JIO A;  2YGW A;  1SIQ A;  3Q0A A;  1GJV A;  3SCE A;  1K8T A;  3VKG A;  3EON A;  2BU8 A;  3LGQ A;  2R0N A;  3PFD A;  4QIC A;  2Q8I A;  1OAH A;  2JBS A;  1RJ1 A;  4MP2 A;  5K3J A;  3TOR A;  1X8Z A;  2BTZ A;  3R7K A;  2GBB A;  2EBH X;  4KTO A;  3D2R A;  4KCF A;  4AKI A;  4AKH A;  1LVC A;  3OWA A;  5K3G A;  1Y8N A;  2OT4 A;  3VKH A;  5K3I A;  2OEV A;  2XS8 A;  3MDD A;  2REH A;  4G97 A;  4MP7 A;  3Q24 A;  1EGD A;  1BUC A;  4L38 A;  2JIF A;  1GKZ A;  3SF6 A;  4MPC A;  4MPE A;  2JBR A;  2BU2 A;  4FF4 A;  2CJ8 A;  3UBR A;  2R02 A;  2QR4 A;  3MPJ A;  3OIB A;  3BNJ A;  4L1F A;  3N0R A;  1Y8P A;  3TZ5 A;  3TZ2 A;  4FF1 A;  3OWM A;  1PI1 A;  3CRK A;  3II9 A;  4L3Z A;  4FF3 A;  4KSF A;  4Q17 A;  2A1T A;  3AFF A;  4LQS B;  3D9D A;  2HJN A;  3LG1 A;  4V25 A;  3P4T A;  2ZO5 A;  3VAD A;  3X29 A;  4L3X A;  2D29 A;  2BU5 A;  4G5E A;  2WBI A;  1XFX A;  2R03 A;  4Q1O A;  3SXQ A;  2C12 A;  2VIG A;  2Z1Q A;  1W07 A;  1WS9 A;  3FO3 A;  2YYJ A;  4E01 A;  3GNC A;  2XS1 A;  3D9G A;  3C46 A;  2AZE A;  2E81 A;  3TTB A;  4IRN A;  3D9F A;  4E00 A;  1IS2 A;  1EGC A;  1SC5 A;  2XQR B;  2VF1 A;  2RFQ A;  1Y0V A;  2YYL A;  3U33 A;  3TZ4 A;  3C3L A;  3CE2 A;  4H81 A;  2OEX A;  4N5F A;  3X0X A;  4F0X A;  2ZDX A;  4Q5B A;  3RKH A;  2DVL A;  3GQT A;  3AFE A;  5BRM A;  3MPI A;  1XFU A;  2CJ6 A;  5GJW E;  4JEK A;  3BNG A;  5M4K A;  5EZ3 A;  3NF4 A;  4HKR A;  4MPN A;  1FS7 A;  4WJY A;  1JM6 A;  2E80 A;  3D6B A;  3KML A;  4KSA A;  1Y8O A;  3TZ0 A;  5J71 A;  2LFW A;  2IX5 A;  2YYI A;  1QDB A;  2C0U A;  2CJ7 A;  1GU6 A;  4J1V A;  4JIZ A;  1T9G A;  3MMO A;  1XFY A;  2YYM A;  2RDZ A;  2Q8G A;  3Q22 A;  3C2P A;  2OJQ A;  4XVX A;  5B5W A;  4P13 A;  1U8V A;  3MXL A;  5B6B A;  1R3B A;  2IX6 A;  4Q4U A;  1K90 A;  4OO2 A;  3MDE A;  5M4N A;  4U83 A;  3UU9 A; 
#chains in the Genus database with same CATH homology
 3BNH A;  4IV6 A;  3F29 A;  2PG0 A;  1FS8 A;  3MKH A;  1RX0 A;  4M9A A;  4RM7 A;  2JBT A;  1FS9 A;  4Q0T A;  3GM6 A;  2EBA A;  5K3H A;  1SIR A;  3M9V A;  2VR0 A;  1UKW A;  2YYG A;  2R0M A;  4X28 C;  2YYK A;  4L3Y A;  2DDH A;  1JQI A;  3L1T A;  2FON A;  3D9E A;  3X0Y A;  3B96 A;  3SWO A;  1EGE A;  3EOM A;  4ZYJ A;  3BNF A;  4HR3 A;  1IVH A;  2UXW A;  3D1I A;  3FCJ A;  2OR0 A;  2CX9 A;  4DOY A;  4W9U A;  3S7W A;  2ZAF A;  1R2J A;  2J7A A;  1UDY A;  4Q5C A;  4ZXV A;  2RF7 A;  4NXL A;  4O5M A;  3HWC A;  4X28 A;  1SIQ A;  3SCE A;  3EON A;  3LGQ A;  2R0N A;  3PFD A;  1OAH A;  2JBS A;  5K3J A;  3TOR A;  3R7K A;  4KTO A;  4KCF A;  3OWA A;  5K3G A;  2OT4 A;  5K3I A;  3MDD A;  2REH A;  1EGD A;  1BUC A;  4L38 A;  2JIF A;  3SF6 A;  2JBR A;  3UBR A;  3MPJ A;  3OIB A;  3BNJ A;  4L1F A;  3OWM A;  3II9 A;  4L3Z A;  4Q17 A;  2A1T A;  3AFF A;  3D9D A;  3LG1 A;  3P4T A;  2ZO5 A;  4L3X A;  2D29 A;  4G5E A;  2WBI A;  4Q1O A;  3SXQ A;  2C12 A;  2VIG A;  2Z1Q A;  1W07 A;  1WS9 A;  3FO3 A;  2YYJ A;  3GNC A;  3D9G A;  2E81 A;  3TTB A;  4IRN A;  3D9F A;  1IS2 A;  1EGC A;  2RFQ A;  2YYL A;  4N5F A;  3X0X A;  4Q5B A;  3RKH A;  2DVL A;  3GQT A;  3AFE A;  3MPI A;  4JEK A;  3BNG A;  3NF4 A;  1FS7 A;  4WJY A;  2E80 A;  3D6B A;  2IX5 A;  2YYI A;  1QDB A;  2C0U A;  1GU6 A;  1T9G A;  3MMO A;  2YYM A;  2RDZ A;  4XVX A;  4P13 A;  1U8V A;  3MXL A;  2IX6 A;  4Q4U A;  4OO2 A;  3MDE A;  4U83 A;  3UU9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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