1SIRA

The crystal structure and mechanism of human glutaryl-coa dehydrogenase
Total Genus 151
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
390
structure length
390
Chain Sequence
EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Oxidoreductase
molecule keywords Glutaryl-CoA dehydrogenase
publication title Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions
pubmed doi rcsb
total genus 151
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2004-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1sirA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1sirA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1sirA02
2C0UA 1RX0A 4HR3A 4L1FA 2YYKA 4Q4UA 2E80A 2J7AA 3II9A 2A1TA 4KTOA 3TTBA 4Q0TA 4ZYJA 3OWAA 2PG0A 3D9DA 4G5EA 5K3HA 4XVXA 1FS9A 2CX9A 2C12A 2OT4A 3S7WA 1IVHA 4O5MA 3MPJA 2DVLA 5K3GA 3D9FA 5K3JA 2D29A 3FCJA 3R7KA 4L3ZA 2RF7A 3HWCA 2YYLA 4IRNA 3AFEA 3X0XA 4RM7A 2RDZA 4L38A 2FONA 2E81A 2VR0A 3D9EA 1GU6A 4Q17A 2JBRA 3TORA 4OO2A 3MMOA 2REHA 2YYMA 1EGDA 1JQIA 2RFQA 2ZAFA 4X28C 4Q1OA 4WJYA 2UXWA 1EGEA 2OR0A 3OWMA 4M9AA 1BUCA 2YYJA 2WBIA 1FS7A 3LGQA 1U8VA 1R2JA 3GM6A 2YYIA 3D6BA 3D9GA 2R0NA 3EOMA 3BNHA 3FO3A 4IV6A 3NF4A 1UKWA 3F29A 2IX5A 2IX6A 3AFFA 3LG1A 2YYGA 4N5FA 3UBRA 4P13A 3X0YA 3BNFA 4NXLA 4Q5CA 3L1TA 3GQTA 1OAHA 3BNJA 4L3XA 2JIFA 3B96A 3P4TA 3GNCA 2VIGA 1IS2A 3SXQA 3D1IA 2ZO5A 4DOYA 1SIQA 3MDEA 4W9UA 2JBTA 3UU9A 3MKHA 1W07A 4L3YA 3EONA 1T9GA 2R0MA 1FS8A 3MDDA 4U83A 3RKHA 1EGCA 3M9VA 3PFDA 4KCFA 3MPIA 3MXLA 2EBAA 3OIBA 3SF6A 1UDYA 4X28A 3BNGA 4Q5BA 5K3IA 2DDHA 4JEKA 3SWOA 3SCEA 2JBSA 1QDBA 2Z1QA 1SIRA 4ZXVA 1WS9A
chains in the Genus database with same CATH superfamily
1K8TA 3N0RA 2C0UA 1RX0A 3VKGA 3TZ5A 4HR3A 4L1FA 2YYKA 4Q4UA 4FF1A 1X90A 2R03A 5M4MA 1Y8PA 4MP7A 2ZDYA 2E80A 2J7AA 3II9A 4F0XA 2A1TA 2OEXA 4KTOA 3CRKA 3Q24A 2ZDXA 3TTBA 1XFXA 2R02A 2CJ7A 4Q0TA 2CJ4A 4ZYJA 3C2PA 5GJVE 2Q8HA 3OWAA 3CE2A 2BU8A 4FZ4A 5B5WA 2PG0A 3D9DA 4G5EA 5K3HA 4XVXA 1FS9A 2CX9A 2C12A 4AKHA 2OT4A 3S7WA 1Y8NA 4MPCA 4JIZA 1IVHA 4O5MA 1GKZA 3MPJA 2DVLA 2BU5A 2Q8IA 2AZEA 2BTZA 2E0AA 4V25A 4G97A 4E00A 5K3GA 2GBBA 3D9FA 4HKSA 3C46A 5K3JA 2HJNA 4AKGA 2D29A 3DJLA 3FCJA 3R7KA 3Q23A 2AO2A 4L3ZA 2RF7A 3HWCA 2YYLA 4IRNA 1JM6A 3AFEA 4MPEA 3X0XA 2OEVA 4FF3A 1Y0VA 3VKHA 4RM7A 2RDZA 2R05A 3KMLA 4L38A 2FONA 1Y8OA 2E81A 3D9EA 2QR4A 1GU6A 2VR0A 4KSAA 3CRLA 4Q17A 2JBRA 3TORA 2BU6A 3U33A 4OO2A 3MMOA 4H81A 2REHA 5J6AA 2YYMA 1EGDA 1JQIA 2RFQA 2ZAFA 4X28C 2EBFX 4Q1OA 4WJYA 2UXWA 1EGEA 2OR0A 3OWMA 4M9AA 1BUCA 1SK6A 2YYJA 2WBIA 1K93A 1X91A 1FS7A 2BU7A 3LGQA 1U8VA 1R2JA 3GM6A 4DZYA 2YYIA 3D6BA 5B6BA 3D9GA 2R0NA 2XQRB 3EOMA 4E01A 3BNHA 2CJ5A 2PNRA 1K90A 2ZKJA 4H7QA 3FO3A 4IV6A 1RP3A 3NF4A 1XFVA 1XG2B 4JIOA 1UKWA 4P79A 3F29A 4AI6A 2IX5A 3C3LA 5M4NA 4FF4A 1GJVA 4LQQB 4E02A 5J71A 2IX6A 3TZ4A 3AFFA 3LG1A 2YYGA 4MPNA 5M4KA 1XFYA 4N5FA 4KSFA 3UBRA 1LVCA 4P13A 1RJ4A 1PI1A 3D2RA 3X0YA 2FP1A 3BNFA 4NXLA 4KS9A 2CJ6A 3L1TA 2BU2A 2VF1A 4J1VA 4Q5CA 2Q8GA 3Q0AA 3GQTA 1OAHA 3BNJA 4FF2A 4L3XA 2Q8FA 2JIFA 1R3BA 3B96A 3P4TA 2XS1A 3GNCA 4AKIA 2VIGA 5BRMA 1IS2A 3SXQA 1XFZA 2ZO5A 2EBHX 4DOYA 3D1IA 1SIQA 3MDEA 4W9UA 1S26A 1X8ZA 2JBTA 2XS8A 2YGWA 1GKXA 3UU9A 3MKHA 3Q22A 4MP2A 1W07A 4L3YA 3EONA 1RJ1A 5GJWE 5EZ3A 4HKRA 2CJ8A 2OJQA 1T9GA 2R0MA 1FS8A 3MDDA 3TZ2A 4U83A 3RKHA 1EGCA 3TZ0A 3M9VA 3PFDA 2EC5A 4KCFA 2PO4A 2F6LA 4QICA 5B5VA 3X29A 3MPIA 3MXLA 2EBAA 3OIBA 3SF6A 1UDYA 4X28A 1XFWA 1SC5A 3BNGA 4Q5BA 5K3IA 4LQSB 3VADA 5BRKA 2DDHA 4JEKA 3SWOA 4V26A 3SCEA 2JBSA 1PK0A 1QDBA 2LFWA 1XFUA 2FP2A 2Z1QA 1SIRA 5M4PA 4ZXVA 4H85A 1WS9A
chains in the Genus database with same CATH topology
2C0UA 1RX0A 4HR3A 4L1FA 2YYKA 4Q4UA 2E80A 2J7AA 3II9A 2A1TA 4KTOA 3TTBA 4Q0TA 4ZYJA 3OWAA 2PG0A 3D9DA 4G5EA 5K3HA 4XVXA 1FS9A 2CX9A 2C12A 2OT4A 3S7WA 1IVHA 4O5MA 3MPJA 2DVLA 5K3GA 3D9FA 5K3JA 2D29A 3FCJA 3R7KA 4L3ZA 2RF7A 3HWCA 2YYLA 4IRNA 3AFEA 3X0XA 4RM7A 2RDZA 4L38A 2FONA 2E81A 2VR0A 3D9EA 1GU6A 4Q17A 2JBRA 3TORA 4OO2A 3MMOA 2REHA 2YYMA 1EGDA 1JQIA 2RFQA 2ZAFA 4X28C 4Q1OA 4WJYA 2UXWA 1EGEA 2OR0A 3OWMA 4M9AA 1BUCA 2YYJA 2WBIA 1FS7A 3LGQA 1U8VA 1R2JA 3GM6A 2YYIA 3D6BA 3D9GA 2R0NA 3EOMA 3BNHA 3FO3A 4IV6A 3NF4A 1UKWA 3F29A 2IX5A 2IX6A 3AFFA 3LG1A 2YYGA 4N5FA 3UBRA 4P13A 3X0YA 3BNFA 4NXLA 4Q5CA 3L1TA 3GQTA 1OAHA 3BNJA 4L3XA 2JIFA 3B96A 3P4TA 3GNCA 2VIGA 1IS2A 3SXQA 3D1IA 2ZO5A 4DOYA 1SIQA 3MDEA 4W9UA 2JBTA 3UU9A 3MKHA 1W07A 4L3YA 3EONA 1T9GA 2R0MA 1FS8A 3MDDA 4U83A 3RKHA 1EGCA 3M9VA 3PFDA 4KCFA 3MPIA 3MXLA 2EBAA 3OIBA 3SF6A 1UDYA 4X28A 3BNGA 4Q5BA 5K3IA 2DDHA 4JEKA 3SWOA 3SCEA 2JBSA 1QDBA 2Z1QA 1SIRA 4ZXVA 1WS9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C0U A;  1RX0 A;  4HR3 A;  4L1F A;  2YYK A;  4Q4U A;  2E80 A;  2J7A A;  3II9 A;  2A1T A;  4KTO A;  3TTB A;  4Q0T A;  4ZYJ A;  3OWA A;  2PG0 A;  3D9D A;  4G5E A;  5K3H A;  4XVX A;  1FS9 A;  2CX9 A;  2C12 A;  2OT4 A;  3S7W A;  1IVH A;  4O5M A;  3MPJ A;  2DVL A;  5K3G A;  3D9F A;  5K3J A;  2D29 A;  3FCJ A;  3R7K A;  4L3Z A;  2RF7 A;  3HWC A;  2YYL A;  4IRN A;  3AFE A;  3X0X A;  4RM7 A;  2RDZ A;  4L38 A;  2FON A;  2E81 A;  2VR0 A;  3D9E A;  1GU6 A;  4Q17 A;  2JBR A;  3TOR A;  4OO2 A;  3MMO A;  2REH A;  2YYM A;  1EGD A;  1JQI A;  2RFQ A;  2ZAF A;  4X28 C;  4Q1O A;  4WJY A;  2UXW A;  1EGE A;  2OR0 A;  3OWM A;  4M9A A;  1BUC A;  2YYJ A;  2WBI A;  1FS7 A;  3LGQ A;  1U8V A;  1R2J A;  3GM6 A;  2YYI A;  3D6B A;  3D9G A;  2R0N A;  3EOM A;  3BNH A;  3FO3 A;  4IV6 A;  3NF4 A;  1UKW A;  3F29 A;  2IX5 A;  2IX6 A;  3AFF A;  3LG1 A;  2YYG A;  4N5F A;  3UBR A;  4P13 A;  3X0Y A;  3BNF A;  4NXL A;  4Q5C A;  3L1T A;  3GQT A;  1OAH A;  3BNJ A;  4L3X A;  2JIF A;  3B96 A;  3P4T A;  3GNC A;  2VIG A;  1IS2 A;  3SXQ A;  3D1I A;  2ZO5 A;  4DOY A;  1SIQ A;  3MDE A;  4W9U A;  2JBT A;  3UU9 A;  3MKH A;  1W07 A;  4L3Y A;  3EON A;  1T9G A;  2R0M A;  1FS8 A;  3MDD A;  4U83 A;  3RKH A;  1EGC A;  3M9V A;  3PFD A;  4KCF A;  3MPI A;  3MXL A;  2EBA A;  3OIB A;  3SF6 A;  1UDY A;  4X28 A;  3BNG A;  4Q5B A;  5K3I A;  2DDH A;  4JEK A;  3SWO A;  3SCE A;  2JBS A;  1QDB A;  2Z1Q A;  1SIR A;  4ZXV A;  1WS9 A; 
#chains in the Genus database with same CATH topology
 1K8T A;  3N0R A;  2C0U A;  1RX0 A;  3VKG A;  3TZ5 A;  4HR3 A;  4L1F A;  2YYK A;  4Q4U A;  4FF1 A;  1X90 A;  2R03 A;  5M4M A;  1Y8P A;  4MP7 A;  2ZDY A;  2E80 A;  2J7A A;  3II9 A;  4F0X A;  2A1T A;  2OEX A;  4KTO A;  3CRK A;  3Q24 A;  2ZDX A;  3TTB A;  1XFX A;  2R02 A;  2CJ7 A;  4Q0T A;  2CJ4 A;  4ZYJ A;  3C2P A;  5GJV E;  2Q8H A;  3OWA A;  3CE2 A;  2BU8 A;  4FZ4 A;  5B5W A;  2PG0 A;  3D9D A;  4G5E A;  5K3H A;  4XVX A;  1FS9 A;  2CX9 A;  2C12 A;  4AKH A;  2OT4 A;  3S7W A;  1Y8N A;  4MPC A;  4JIZ A;  1IVH A;  4O5M A;  1GKZ A;  3MPJ A;  2DVL A;  2BU5 A;  2Q8I A;  2AZE A;  2BTZ A;  2E0A A;  4V25 A;  4G97 A;  4E00 A;  5K3G A;  2GBB A;  3D9F A;  4HKS A;  3C46 A;  5K3J A;  2HJN A;  4AKG A;  2D29 A;  3DJL A;  3FCJ A;  3R7K A;  3Q23 A;  2AO2 A;  4L3Z A;  2RF7 A;  3HWC A;  2YYL A;  4IRN A;  1JM6 A;  3AFE A;  4MPE A;  3X0X A;  2OEV A;  4FF3 A;  1Y0V A;  3VKH A;  4RM7 A;  2RDZ A;  2R05 A;  3KML A;  4L38 A;  2FON A;  1Y8O A;  2E81 A;  3D9E A;  2QR4 A;  1GU6 A;  2VR0 A;  4KSA A;  3CRL A;  4Q17 A;  2JBR A;  3TOR A;  2BU6 A;  3U33 A;  4OO2 A;  3MMO A;  4H81 A;  2REH A;  5J6A A;  2YYM A;  1EGD A;  1JQI A;  2RFQ A;  2ZAF A;  4X28 C;  2EBF X;  4Q1O A;  4WJY A;  2UXW A;  1EGE A;  2OR0 A;  3OWM A;  4M9A A;  1BUC A;  1SK6 A;  2YYJ A;  2WBI A;  1K93 A;  1X91 A;  1FS7 A;  2BU7 A;  3LGQ A;  1U8V A;  1R2J A;  3GM6 A;  4DZY A;  2YYI A;  3D6B A;  5B6B A;  3D9G A;  2R0N A;  2XQR B;  3EOM A;  4E01 A;  3BNH A;  2CJ5 A;  2PNR A;  1K90 A;  2ZKJ A;  4H7Q A;  3FO3 A;  4IV6 A;  1RP3 A;  3NF4 A;  1XFV A;  1XG2 B;  4JIO A;  1UKW A;  4P79 A;  3F29 A;  4AI6 A;  2IX5 A;  3C3L A;  5M4N A;  4FF4 A;  1GJV A;  4LQQ B;  4E02 A;  5J71 A;  2IX6 A;  3TZ4 A;  3AFF A;  3LG1 A;  2YYG A;  4MPN A;  5M4K A;  1XFY A;  4N5F A;  4KSF A;  3UBR A;  1LVC A;  4P13 A;  1RJ4 A;  1PI1 A;  3D2R A;  3X0Y A;  2FP1 A;  3BNF A;  4NXL A;  4KS9 A;  2CJ6 A;  3L1T A;  2BU2 A;  2VF1 A;  4J1V A;  4Q5C A;  2Q8G A;  3Q0A A;  3GQT A;  1OAH A;  3BNJ A;  4FF2 A;  4L3X A;  2Q8F A;  2JIF A;  1R3B A;  3B96 A;  3P4T A;  2XS1 A;  3GNC A;  4AKI A;  2VIG A;  5BRM A;  1IS2 A;  3SXQ A;  1XFZ A;  2ZO5 A;  2EBH X;  4DOY A;  3D1I A;  1SIQ A;  3MDE A;  4W9U A;  1S26 A;  1X8Z A;  2JBT A;  2XS8 A;  2YGW A;  1GKX A;  3UU9 A;  3MKH A;  3Q22 A;  4MP2 A;  1W07 A;  4L3Y A;  3EON A;  1RJ1 A;  5GJW E;  5EZ3 A;  4HKR A;  2CJ8 A;  2OJQ A;  1T9G A;  2R0M A;  1FS8 A;  3MDD A;  3TZ2 A;  4U83 A;  3RKH A;  1EGC A;  3TZ0 A;  3M9V A;  3PFD A;  2EC5 A;  4KCF A;  2PO4 A;  2F6L A;  4QIC A;  5B5V A;  3X29 A;  3MPI A;  3MXL A;  2EBA A;  3OIB A;  3SF6 A;  1UDY A;  4X28 A;  1XFW A;  1SC5 A;  3BNG A;  4Q5B A;  5K3I A;  4LQS B;  3VAD A;  5BRK A;  2DDH A;  4JEK A;  3SWO A;  4V26 A;  3SCE A;  2JBS A;  1PK0 A;  1QDB A;  2LFW A;  1XFU A;  2FP2 A;  2Z1Q A;  1SIR A;  5M4P A;  4ZXV A;  4H85 A;  1WS9 A; 
#chains in the Genus database with same CATH homology
 2C0U A;  1RX0 A;  4HR3 A;  4L1F A;  2YYK A;  4Q4U A;  2E80 A;  2J7A A;  3II9 A;  2A1T A;  4KTO A;  3TTB A;  4Q0T A;  4ZYJ A;  3OWA A;  2PG0 A;  3D9D A;  4G5E A;  5K3H A;  4XVX A;  1FS9 A;  2CX9 A;  2C12 A;  2OT4 A;  3S7W A;  1IVH A;  4O5M A;  3MPJ A;  2DVL A;  5K3G A;  3D9F A;  5K3J A;  2D29 A;  3FCJ A;  3R7K A;  4L3Z A;  2RF7 A;  3HWC A;  2YYL A;  4IRN A;  3AFE A;  3X0X A;  4RM7 A;  2RDZ A;  4L38 A;  2FON A;  2E81 A;  2VR0 A;  3D9E A;  1GU6 A;  4Q17 A;  2JBR A;  3TOR A;  4OO2 A;  3MMO A;  2REH A;  2YYM A;  1EGD A;  1JQI A;  2RFQ A;  2ZAF A;  4X28 C;  4Q1O A;  4WJY A;  2UXW A;  1EGE A;  2OR0 A;  3OWM A;  4M9A A;  1BUC A;  2YYJ A;  2WBI A;  1FS7 A;  3LGQ A;  1U8V A;  1R2J A;  3GM6 A;  2YYI A;  3D6B A;  3D9G A;  2R0N A;  3EOM A;  3BNH A;  3FO3 A;  4IV6 A;  3NF4 A;  1UKW A;  3F29 A;  2IX5 A;  2IX6 A;  3AFF A;  3LG1 A;  2YYG A;  4N5F A;  3UBR A;  4P13 A;  3X0Y A;  3BNF A;  4NXL A;  4Q5C A;  3L1T A;  3GQT A;  1OAH A;  3BNJ A;  4L3X A;  2JIF A;  3B96 A;  3P4T A;  3GNC A;  2VIG A;  1IS2 A;  3SXQ A;  3D1I A;  2ZO5 A;  4DOY A;  1SIQ A;  3MDE A;  4W9U A;  2JBT A;  3UU9 A;  3MKH A;  1W07 A;  4L3Y A;  3EON A;  1T9G A;  2R0M A;  1FS8 A;  3MDD A;  4U83 A;  3RKH A;  1EGC A;  3M9V A;  3PFD A;  4KCF A;  3MPI A;  3MXL A;  2EBA A;  3OIB A;  3SF6 A;  1UDY A;  4X28 A;  3BNG A;  4Q5B A;  5K3I A;  2DDH A;  4JEK A;  3SWO A;  3SCE A;  2JBS A;  1QDB A;  2Z1Q A;  1SIR A;  4ZXV A;  1WS9 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...