1SIRA

The crystal structure and mechanism of human glutaryl-coa dehydrogenase
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
390
structure length
390
Chain Sequence
b'EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutaryl-CoA dehydrogenase
publication title Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions
pubmed doi rcsb
molecule tags Oxidoreductase
total genus 151
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2004-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1sirA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1sirA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1sirA02
3BNFA 4X28C 3D9GA 1OAHA 1SIRA 2YYIA 4X28A 4L1FA 2E81A 4HR3A 2FONA 3D9DA 4ZXVA 4M9AA 2YYMA 3M9VA 5K3GA 2DDHA 3NF4A 4ZYJA 3BNHA 4OO2A 2EBAA 1RX0A 3MPJA 4Q4UA 3SF6A 4WJYA 4Q17A 3MPIA 4O5MA 1FS8A 4W9UA 4L3YA 2J7AA 2OT4A 1WS9A 4DOYA 2OR0A 2Z1QA 4IRNA 5K3JA 3GQTA 3AFFA 3P4TA 3LGQA 3RKHA 3D1IA 2YYKA 3MDEA 3R7KA 3D6BA 2RFQA 3GNCA 4P13A 2C0UA 2REHA 4N5FA 2R0NA 2JBTA 3D9FA 4L38A 1EGDA 1W07A 3BNJA 3MMOA 2IX5A 3L1TA 2C12A 2IX6A 2YYGA 3MXLA 3EONA 4XVXA 3X0YA 3MDDA 2JIFA 2VR0A 3AFEA 4NXLA 3SWOA 1FS7A 3X0XA 3II9A 3HWCA 4L3XA 2WBIA 3LG1A 3TTBA 1R2JA 5K3IA 1GU6A 1EGCA 3BNGA 4L3ZA 3OIBA 3B96A 4U83A 3PFDA 4RM7A 2RDZA 2RF7A 3FO3A 4Q1OA 1UDYA 3UBRA 2YYLA 3MKHA 3TORA 2YYJA 1JQIA 3D9EA 2PG0A 2ZAFA 2UXWA 3SCEA 2A1TA 3OWAA 4G5EA 4Q0TA 4KCFA 3GM6A 1BUCA 2E80A 1U8VA 2VIGA 4JEKA 4KTOA 3F29A 5K3HA 3OWMA 1SIQA 2D29A 3FCJA 3S7WA 1FS9A 4Q5BA 1IS2A 2ZO5A 4IV6A 3UU9A 3EOMA 1IVHA 1T9GA 1EGEA 2DVLA 1QDBA 2R0MA 4Q5CA 2JBSA 3SXQA 2CX9A 1UKWA 2JBRA
chains in the Genus database with same CATH superfamily
3BNFA 1XFZA 4X28C 2R03A 3D9GA 2YGWA 1OAHA 2GBBA 2ZDXA 3Q23A 1SIRA 2YYIA 4E01A 3DJLA 1RJ1A 4X28A 4F0XA 5J6AA 4L1FA 4MPEA 5B5VA 2E81A 4HR3A 4FF3A 5GJVE 2FONA 3D9DA 4ZXVA 1LVCA 1XFUA 5GJWE 2CJ4A 3TZ0A 4FF1A 4M9AA 3U33A 2R05A 2YYMA 4MP2A 4V26A 4HKSA 3M9VA 4FF2A 5K3GA 2DDHA 3NF4A 4ZYJA 3BNHA 4OO2A 2EBAA 1RX0A 3MPJA 4LQSB 4Q4UA 3SF6A 2Q8IA 2CJ6A 2BU2A 4WJYA 4Q17A 3MPIA 4O5MA 4AI6A 1FS8A 4W9UA 2CJ5A 2OEVA 4L3YA 3Q24A 4AKGA 2J7AA 2OT4A 1WS9A 4DOYA 2LFWA 2CJ7A 1SC5A 2FP2A 2EC5A 2OR0A 2Z1QA 2XS8A 3KMLA 4G97A 4IRNA 5K3JA 1K90A 2F6LA 3C3LA 3C46A 4AKHA 3GQTA 3AFFA 3P4TA 4KSAA 1XFYA 4MPCA 3LGQA 3RKHA 3D1IA 2YYKA 5B5WA 3MDEA 3R7KA 4V25A 3D6BA 1JM6A 2RFQA 3GNCA 4P13A 2C0UA 5B6BA 2REHA 4N5FA 2R0NA 2JBTA 3D9FA 3CRLA 4L38A 1EGDA 1W07A 2BU5A 3BNJA 3MMOA 2IX5A 3L1TA 5EZ3A 4FZ4A 2C12A 1SK6A 2IX6A 2VF1A 4KS9A 4MP7A 3VADA 2YYGA 5M4MA 3MXLA 3Q22A 3EONA 4XVXA 4H85A 3X0YA 1K8TA 3MDDA 2JIFA 2VR0A 3AFEA 4NXLA 3SWOA 1FS7A 5BRMA 3X0XA 5J71A 4AKIA 3II9A 3HWCA 3CRKA 3TZ5A 1PK0A 4L3XA 2WBIA 3LG1A 5M4KA 2E0AA 3TTBA 1R2JA 5K3IA 1GU6A 1EGCA 3BNGA 4L3ZA 3OIBA 2OEXA 3B96A 4U83A 3PFDA 4RM7A 2AZEA 2RDZA 2RF7A 3FO3A 4E02A 4KSFA 4Q1OA 3VKGA 1UDYA 1GJVA 1Y8OA 3Q0AA 2OJQA 3X29A 3UBRA 2AO2A 2YYLA 3CE2A 3MKHA 3VKHA 2HJNA 4P79A 3TORA 2YYJA 1JQIA 3D9EA 4FF4A 2PG0A 2ZKJA 2ZAFA 4LQQB 2CJ8A 1Y0VA 3N0RA 1GKZA 1K93A 1GKXA 1RP3A 2UXWA 1S26A 2Q8HA 2A1TA 3OWAA 1XFWA 3SCEA 2EBFX 2BU7A 2XQRB 4KCFA 3GM6A 2EBHX 4G5EA 4Q0TA 3TZ2A 3TZ4A 1BUCA 2E80A 2Q8GA 1U8VA 2VIGA 4JEKA 4KTOA 4QICA 2R02A 3F29A 1PI1A 5K3HA 3D2RA 3OWMA 4E00A 1SIQA 4DZYA 2D29A 1XG2B 3FCJA 1Y8NA 2PO4A 3S7WA 5BRKA 1FS9A 1XFXA 5M4NA 4Q5BA 1X91A 1X90A 2ZDYA 4JIOA 4HKRA 3C2PA 1X8ZA 1Y8PA 1IS2A 2QR4A 4H7QA 2ZO5A 2FP1A 4IV6A 3UU9A 3EOMA 2XS1A 1IVHA 5M4PA 1T9GA 1EGEA 2DVLA 1QDBA 4J1VA 2R0MA 2BU8A 4Q5CA 2JBSA 2BTZA 3SXQA 4MPNA 2PNRA 2BU6A 2CX9A 4H81A 1UKWA 1XFVA 2JBRA 4JIZA 1RJ4A 1R3BA 2Q8FA
chains in the Genus database with same CATH topology
3BNFA 4X28C 3D9GA 1OAHA 1SIRA 2YYIA 4X28A 4L1FA 2E81A 4HR3A 2FONA 3D9DA 4ZXVA 4M9AA 2YYMA 3M9VA 5K3GA 2DDHA 3NF4A 4ZYJA 3BNHA 4OO2A 2EBAA 1RX0A 3MPJA 4Q4UA 3SF6A 4WJYA 4Q17A 3MPIA 4O5MA 1FS8A 4W9UA 4L3YA 2J7AA 2OT4A 1WS9A 4DOYA 2OR0A 2Z1QA 4IRNA 5K3JA 3GQTA 3AFFA 3P4TA 3LGQA 3RKHA 3D1IA 2YYKA 3MDEA 3R7KA 3D6BA 2RFQA 3GNCA 4P13A 2C0UA 2REHA 4N5FA 2R0NA 2JBTA 3D9FA 4L38A 1EGDA 1W07A 3BNJA 3MMOA 2IX5A 3L1TA 2C12A 2IX6A 2YYGA 3MXLA 3EONA 4XVXA 3X0YA 3MDDA 2JIFA 2VR0A 3AFEA 4NXLA 3SWOA 1FS7A 3X0XA 3II9A 3HWCA 4L3XA 2WBIA 3LG1A 3TTBA 1R2JA 5K3IA 1GU6A 1EGCA 3BNGA 4L3ZA 3OIBA 3B96A 4U83A 3PFDA 4RM7A 2RDZA 2RF7A 3FO3A 4Q1OA 1UDYA 3UBRA 2YYLA 3MKHA 3TORA 2YYJA 1JQIA 3D9EA 2PG0A 2ZAFA 2UXWA 3SCEA 2A1TA 3OWAA 4G5EA 4Q0TA 4KCFA 3GM6A 1BUCA 2E80A 1U8VA 2VIGA 4JEKA 4KTOA 3F29A 5K3HA 3OWMA 1SIQA 2D29A 3FCJA 3S7WA 1FS9A 4Q5BA 1IS2A 2ZO5A 4IV6A 3UU9A 3EOMA 1IVHA 1T9GA 1EGEA 2DVLA 1QDBA 2R0MA 4Q5CA 2JBSA 3SXQA 2CX9A 1UKWA 2JBRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BNF A;  4X28 C;  3D9G A;  1OAH A;  1SIR A;  2YYI A;  4X28 A;  4L1F A;  2E81 A;  4HR3 A;  2FON A;  3D9D A;  4ZXV A;  4M9A A;  2YYM A;  3M9V A;  5K3G A;  2DDH A;  3NF4 A;  4ZYJ A;  3BNH A;  4OO2 A;  2EBA A;  1RX0 A;  3MPJ A;  4Q4U A;  3SF6 A;  4WJY A;  4Q17 A;  3MPI A;  4O5M A;  1FS8 A;  4W9U A;  4L3Y A;  2J7A A;  2OT4 A;  1WS9 A;  4DOY A;  2OR0 A;  2Z1Q A;  4IRN A;  5K3J A;  3GQT A;  3AFF A;  3P4T A;  3LGQ A;  3RKH A;  3D1I A;  2YYK A;  3MDE A;  3R7K A;  3D6B A;  2RFQ A;  3GNC A;  4P13 A;  2C0U A;  2REH A;  4N5F A;  2R0N A;  2JBT A;  3D9F A;  4L38 A;  1EGD A;  1W07 A;  3BNJ A;  3MMO A;  2IX5 A;  3L1T A;  2C12 A;  2IX6 A;  2YYG A;  3MXL A;  3EON A;  4XVX A;  3X0Y A;  3MDD A;  2JIF A;  2VR0 A;  3AFE A;  4NXL A;  3SWO A;  1FS7 A;  3X0X A;  3II9 A;  3HWC A;  4L3X A;  2WBI A;  3LG1 A;  3TTB A;  1R2J A;  5K3I A;  1GU6 A;  1EGC A;  3BNG A;  4L3Z A;  3OIB A;  3B96 A;  4U83 A;  3PFD A;  4RM7 A;  2RDZ A;  2RF7 A;  3FO3 A;  4Q1O A;  1UDY A;  3UBR A;  2YYL A;  3MKH A;  3TOR A;  2YYJ A;  1JQI A;  3D9E A;  2PG0 A;  2ZAF A;  2UXW A;  3SCE A;  2A1T A;  3OWA A;  4G5E A;  4Q0T A;  4KCF A;  3GM6 A;  1BUC A;  2E80 A;  1U8V A;  2VIG A;  4JEK A;  4KTO A;  3F29 A;  5K3H A;  3OWM A;  1SIQ A;  2D29 A;  3FCJ A;  3S7W A;  1FS9 A;  4Q5B A;  1IS2 A;  2ZO5 A;  4IV6 A;  3UU9 A;  3EOM A;  1IVH A;  1T9G A;  1EGE A;  2DVL A;  1QDB A;  2R0M A;  4Q5C A;  2JBS A;  3SXQ A;  2CX9 A;  1UKW A;  2JBR A; 
#chains in the Genus database with same CATH topology
 3BNF A;  1XFZ A;  4X28 C;  2R03 A;  3D9G A;  2YGW A;  1OAH A;  2GBB A;  2ZDX A;  3Q23 A;  1SIR A;  2YYI A;  4E01 A;  3DJL A;  1RJ1 A;  4X28 A;  4F0X A;  5J6A A;  4L1F A;  4MPE A;  5B5V A;  2E81 A;  4HR3 A;  4FF3 A;  5GJV E;  2FON A;  3D9D A;  4ZXV A;  1LVC A;  1XFU A;  5GJW E;  2CJ4 A;  3TZ0 A;  4FF1 A;  4M9A A;  3U33 A;  2R05 A;  2YYM A;  4MP2 A;  4V26 A;  4HKS A;  3M9V A;  4FF2 A;  5K3G A;  2DDH A;  3NF4 A;  4ZYJ A;  3BNH A;  4OO2 A;  2EBA A;  1RX0 A;  3MPJ A;  4LQS B;  4Q4U A;  3SF6 A;  2Q8I A;  2CJ6 A;  2BU2 A;  4WJY A;  4Q17 A;  3MPI A;  4O5M A;  4AI6 A;  1FS8 A;  4W9U A;  2CJ5 A;  2OEV A;  4L3Y A;  3Q24 A;  4AKG A;  2J7A A;  2OT4 A;  1WS9 A;  4DOY A;  2LFW A;  2CJ7 A;  1SC5 A;  2FP2 A;  2EC5 A;  2OR0 A;  2Z1Q A;  2XS8 A;  3KML A;  4G97 A;  4IRN A;  5K3J A;  1K90 A;  2F6L A;  3C3L A;  3C46 A;  4AKH A;  3GQT A;  3AFF A;  3P4T A;  4KSA A;  1XFY A;  4MPC A;  3LGQ A;  3RKH A;  3D1I A;  2YYK A;  5B5W A;  3MDE A;  3R7K A;  4V25 A;  3D6B A;  1JM6 A;  2RFQ A;  3GNC A;  4P13 A;  2C0U A;  5B6B A;  2REH A;  4N5F A;  2R0N A;  2JBT A;  3D9F A;  3CRL A;  4L38 A;  1EGD A;  1W07 A;  2BU5 A;  3BNJ A;  3MMO A;  2IX5 A;  3L1T A;  5EZ3 A;  4FZ4 A;  2C12 A;  1SK6 A;  2IX6 A;  2VF1 A;  4KS9 A;  4MP7 A;  3VAD A;  2YYG A;  5M4M A;  3MXL A;  3Q22 A;  3EON A;  4XVX A;  4H85 A;  3X0Y A;  1K8T A;  3MDD A;  2JIF A;  2VR0 A;  3AFE A;  4NXL A;  3SWO A;  1FS7 A;  5BRM A;  3X0X A;  5J71 A;  4AKI A;  3II9 A;  3HWC A;  3CRK A;  3TZ5 A;  1PK0 A;  4L3X A;  2WBI A;  3LG1 A;  5M4K A;  2E0A A;  3TTB A;  1R2J A;  5K3I A;  1GU6 A;  1EGC A;  3BNG A;  4L3Z A;  3OIB A;  2OEX A;  3B96 A;  4U83 A;  3PFD A;  4RM7 A;  2AZE A;  2RDZ A;  2RF7 A;  3FO3 A;  4E02 A;  4KSF A;  4Q1O A;  3VKG A;  1UDY A;  1GJV A;  1Y8O A;  3Q0A A;  2OJQ A;  3X29 A;  3UBR A;  2AO2 A;  2YYL A;  3CE2 A;  3MKH A;  3VKH A;  2HJN A;  4P79 A;  3TOR A;  2YYJ A;  1JQI A;  3D9E A;  4FF4 A;  2PG0 A;  2ZKJ A;  2ZAF A;  4LQQ B;  2CJ8 A;  1Y0V A;  3N0R A;  1GKZ A;  1K93 A;  1GKX A;  1RP3 A;  2UXW A;  1S26 A;  2Q8H A;  2A1T A;  3OWA A;  1XFW A;  3SCE A;  2EBF X;  2BU7 A;  2XQR B;  4KCF A;  3GM6 A;  2EBH X;  4G5E A;  4Q0T A;  3TZ2 A;  3TZ4 A;  1BUC A;  2E80 A;  2Q8G A;  1U8V A;  2VIG A;  4JEK A;  4KTO A;  4QIC A;  2R02 A;  3F29 A;  1PI1 A;  5K3H A;  3D2R A;  3OWM A;  4E00 A;  1SIQ A;  4DZY A;  2D29 A;  1XG2 B;  3FCJ A;  1Y8N A;  2PO4 A;  3S7W A;  5BRK A;  1FS9 A;  1XFX A;  5M4N A;  4Q5B A;  1X91 A;  1X90 A;  2ZDY A;  4JIO A;  4HKR A;  3C2P A;  1X8Z A;  1Y8P A;  1IS2 A;  2QR4 A;  4H7Q A;  2ZO5 A;  2FP1 A;  4IV6 A;  3UU9 A;  3EOM A;  2XS1 A;  1IVH A;  5M4P A;  1T9G A;  1EGE A;  2DVL A;  1QDB A;  4J1V A;  2R0M A;  2BU8 A;  4Q5C A;  2JBS A;  2BTZ A;  3SXQ A;  4MPN A;  2PNR A;  2BU6 A;  2CX9 A;  4H81 A;  1UKW A;  1XFV A;  2JBR A;  4JIZ A;  1RJ4 A;  1R3B A;  2Q8F A; 
#chains in the Genus database with same CATH homology
 3BNF A;  4X28 C;  3D9G A;  1OAH A;  1SIR A;  2YYI A;  4X28 A;  4L1F A;  2E81 A;  4HR3 A;  2FON A;  3D9D A;  4ZXV A;  4M9A A;  2YYM A;  3M9V A;  5K3G A;  2DDH A;  3NF4 A;  4ZYJ A;  3BNH A;  4OO2 A;  2EBA A;  1RX0 A;  3MPJ A;  4Q4U A;  3SF6 A;  4WJY A;  4Q17 A;  3MPI A;  4O5M A;  1FS8 A;  4W9U A;  4L3Y A;  2J7A A;  2OT4 A;  1WS9 A;  4DOY A;  2OR0 A;  2Z1Q A;  4IRN A;  5K3J A;  3GQT A;  3AFF A;  3P4T A;  3LGQ A;  3RKH A;  3D1I A;  2YYK A;  3MDE A;  3R7K A;  3D6B A;  2RFQ A;  3GNC A;  4P13 A;  2C0U A;  2REH A;  4N5F A;  2R0N A;  2JBT A;  3D9F A;  4L38 A;  1EGD A;  1W07 A;  3BNJ A;  3MMO A;  2IX5 A;  3L1T A;  2C12 A;  2IX6 A;  2YYG A;  3MXL A;  3EON A;  4XVX A;  3X0Y A;  3MDD A;  2JIF A;  2VR0 A;  3AFE A;  4NXL A;  3SWO A;  1FS7 A;  3X0X A;  3II9 A;  3HWC A;  4L3X A;  2WBI A;  3LG1 A;  3TTB A;  1R2J A;  5K3I A;  1GU6 A;  1EGC A;  3BNG A;  4L3Z A;  3OIB A;  3B96 A;  4U83 A;  3PFD A;  4RM7 A;  2RDZ A;  2RF7 A;  3FO3 A;  4Q1O A;  1UDY A;  3UBR A;  2YYL A;  3MKH A;  3TOR A;  2YYJ A;  1JQI A;  3D9E A;  2PG0 A;  2ZAF A;  2UXW A;  3SCE A;  2A1T A;  3OWA A;  4G5E A;  4Q0T A;  4KCF A;  3GM6 A;  1BUC A;  2E80 A;  1U8V A;  2VIG A;  4JEK A;  4KTO A;  3F29 A;  5K3H A;  3OWM A;  1SIQ A;  2D29 A;  3FCJ A;  3S7W A;  1FS9 A;  4Q5B A;  1IS2 A;  2ZO5 A;  4IV6 A;  3UU9 A;  3EOM A;  1IVH A;  1T9G A;  1EGE A;  2DVL A;  1QDB A;  2R0M A;  4Q5C A;  2JBS A;  3SXQ A;  2CX9 A;  1UKW A;  2JBR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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