2YYJA

Crystal structure of the oxygenase component (hpab) of 4-hydroxyphenylacetate 3-monooxygenase complexed with fad and 4-hydroxyphenylacetate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
476
structure length
476
Chain Sequence
ARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTYEEEGKRHGMSFLIPKTKEDLKRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPDPYIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSTLLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLSSRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFLGVAALMAEGIGADVYGHVQEKIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFLEKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIRAFLKESLKVFE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords 4-hydroxyphenylacetate-3-hydroxylase
publication title Crystal Structure of the Oxygenase Component (HpaB) of the 4-Hydroxyphenylacetate 3-Monooxygenase from Thermus thermophilus HB8
pubmed doi rcsb
source organism Thermus thermophilus
molecule tags Oxidoreductase
total genus 178
structure length 476
sequence length 476
ec nomenclature ec 1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase.
pdb deposition date 2007-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03241 HpaB 4-hydroxyphenylacetate 3-hydroxylase C terminal
A PF11794 HpaB_N 4-hydroxyphenylacetate 3-hydroxylase N terminal
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3140.10 Mainly Alpha Orthogonal Bundle 4-hydroxybutyryl-coa dehydratase, domain 1 4-hydroxybutyryl-coa dehydratase, domain 1 2yyjA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 2yyjA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 2yyjA02
1BUCA 3MDEA 3OIBA 2WBIA 2A1TA 1R2JA 2IX5A 4L3YA 3R7KA 3PFDA 4DOYA 2R0MA 2D29A 3D9FA 3NF4A 2YYLA 1JQIA 2C12A 3MPJA 5K3IA 3X0XA 4G5EA 4N5FA 1U8VA 3II9A 3MPIA 2JBRA 4HR3A 2OR0A 4M9AA 3EOMA 5K3HA 1SIQA 4Q0TA 1QDBA 1OAHA 3S7WA 3LG1A 4ZYJA 2YYJA 1EGDA 3UBRA 3M9VA 1WS9A 3F29A 1FS7A 4W9UA 2E80A 2JBTA 4OO2A 2FONA 3AFEA 2C0UA 3BNHA 3MXLA 1W07A 4X28C 4KCFA 3D9EA 2JIFA 3TORA 4P13A 2R0NA 1UDYA 1EGEA 3GNCA 2RFQA 2ZO5A 2DDHA 2OT4A 2YYIA 3EONA 3BNJA 3GQTA 4WJYA 1FS9A 2RDZA 2ZAFA 4IRNA 4IV6A 4L38A 1SIRA 3BNGA 3B96A 3MMOA 2JBSA 1FS8A 4XVXA 4L1FA 4O5MA 2PG0A 4Q17A 2Z1QA 5K3JA 4KTOA 2J7AA 3X0YA 4Q1OA 3MKHA 3HWCA 3AFFA 3GM6A 3D9GA 1IVHA 3BNFA 3D9DA 4Q5BA 4Q5CA 2VIGA 3SWOA 1RX0A 3UU9A 3LGQA 4X28A 2E81A 3OWAA 4JEKA 3OWMA 2VR0A 1EGCA 3L1TA 5K3GA 2YYMA 2IX6A 4L3XA 3D6BA 3FCJA 2REHA 2EBAA 3SCEA 3D1IA 4ZXVA 4Q4UA 1T9GA 4U83A 1IS2A 1GU6A 3SXQA 1UKWA 2CX9A 3TTBA 4NXLA 4RM7A 4L3ZA 2DVLA 3RKHA 2YYKA 2RF7A 3SF6A 2UXWA 3P4TA 3MDDA 2YYGA 3FO3A
chains in the Genus database with same CATH superfamily
2EC5A 1BUCA 3MDEA 3OIBA 1Y8PA 2A1TA 1R2JA 2IX5A 2WBIA 4L3YA 3PFDA 3R7KA 4DOYA 2R0MA 2D29A 2BU5A 2PO4A 3D9FA 3NF4A 5M4PA 2YYLA 1JQIA 2C12A 3MPJA 4LQQB 2R03A 5K3IA 2YGWA 1GKXA 3X0XA 2BU6A 2CJ6A 4G5EA 4N5FA 1K93A 1XFWA 4AKHA 5EZ3A 4MPCA 5BRKA 1GJVA 4LQSB 1U8VA 3U33A 2QR4A 4MP7A 4E02A 1SK6A 3KMLA 3II9A 1XFYA 3MPIA 4FF4A 1K8TA 2FP1A 1RJ1A 1XFXA 2JBRA 4HR3A 2OR0A 4M9AA 2OEVA 3EOMA 1SIQA 5K3HA 4Q0TA 1QDBA 3X29A 1XFZA 2XS1A 1OAHA 5B6BA 3S7WA 5M4MA 3LG1A 4AI6A 4ZYJA 2YYJA 1EGDA 3UBRA 1JM6A 2EBHX 1WS9A 3M9VA 2E0AA 3F29A 4FF1A 1FS7A 4W9UA 1Y8OA 2E80A 2JBTA 1XFVA 2AZEA 2CJ8A 2FONA 2ZDXA 3AFEA 4JIZA 4OO2A 2C0UA 3BNHA 3MXLA 1W07A 4X28C 4E01A 5J71A 4KCFA 4MPEA 3D9EA 3Q23A 2JIFA 2FP2A 3TORA 4P13A 2XQRB 1X8ZA 2R0NA 1UDYA 1EGEA 3GNCA 2RFQA 4J1VA 1R3BA 1PI1A 4MPNA 2Q8HA 2ZO5A 2DDHA 2OT4A 3VKGA 2BU7A 2OEXA 2YYIA 2VF1A 3BNJA 1SC5A 3EONA 1RJ4A 3GQTA 4WJYA 1FS9A 4H85A 4FZ4A 2RDZA 2ZAFA 2XS8A 4IRNA 4IV6A 3TZ2A 5J6AA 4G97A 4L38A 1SIRA 3Q0AA 3BNGA 4H81A 2ZKJA 3B96A 2PNRA 2Q8GA 3MMOA 4QICA 5M4NA 2JBSA 1FS8A 2CJ7A 5BRMA 4XVXA 2Q8IA 5M4KA 4L1FA 4O5MA 3Q24A 2PG0A 4Q17A 4F0XA 2Z1QA 5K3JA 4KTOA 2J7AA 1GKZA 2LFWA 3C3LA 3X0YA 1Y0VA 4E00A 4H7QA 4Q1OA 3MKHA 3HWCA 2GBBA 3C46A 2F6LA 3N0RA 4V26A 3AFFA 3GM6A 3D9GA 1S26A 2BU8A 3CRLA 1IVHA 2BU2A 3BNFA 4HKSA 3TZ0A 3D9DA 4Q5BA 1PK0A 4P79A 1XG2B 3TZ4A 5GJVE 4Q5CA 2VIGA 1X91A 4FF2A 3SWOA 1RX0A 3D2RA 4MP2A 3UU9A 4AKIA 3LGQA 4X28A 2E81A 5B5WA 3VKHA 2AO2A 3Q22A 3OWAA 4JEKA 3CRKA 3OWMA 1X90A 2VR0A 1EGCA 2HJNA 3L1TA 5K3GA 2YYMA 2ZDYA 2IX6A 4L3XA 4KSAA 2BTZA 2CJ4A 1Y8NA 2REHA 3D6BA 2R02A 2EBAA 3FCJA 5B5VA 3SCEA 3D1IA 4KSFA 4ZXVA 4Q4UA 3VADA 1T9GA 4U83A 2R05A 1RP3A 1IS2A 1GU6A 2OJQA 4V25A 2Q8FA 1UKWA 2CX9A 3SXQA 3TTBA 4FF3A 4KS9A 4NXLA 2CJ5A 1K90A 1LVCA 1XFUA 4RM7A 3TZ5A 3DJLA 4L3ZA 2DVLA 3CE2A 3RKHA 2YYKA 2RF7A 4DZYA 3SF6A 2UXWA 3P4TA 4JIOA 2EBFX 3MDDA 3C2PA 4HKRA 2YYGA 3FO3A 4AKGA 5GJWE
chains in the Genus database with same CATH topology
1BUCA 3MDEA 3OIBA 2WBIA 2A1TA 1R2JA 2IX5A 4L3YA 3R7KA 3PFDA 4DOYA 2R0MA 2D29A 3D9FA 3NF4A 2YYLA 1JQIA 2C12A 3MPJA 5K3IA 3X0XA 4G5EA 4N5FA 1U8VA 3II9A 3MPIA 2JBRA 4HR3A 2OR0A 4M9AA 3EOMA 5K3HA 1SIQA 4Q0TA 1QDBA 1OAHA 3S7WA 3LG1A 4ZYJA 2YYJA 1EGDA 3UBRA 3M9VA 1WS9A 3F29A 1FS7A 4W9UA 2E80A 2JBTA 4OO2A 2FONA 3AFEA 2C0UA 3BNHA 3MXLA 1W07A 4X28C 4KCFA 3D9EA 2JIFA 3TORA 4P13A 2R0NA 1UDYA 1EGEA 3GNCA 2RFQA 2ZO5A 2DDHA 2OT4A 2YYIA 3EONA 3BNJA 3GQTA 4WJYA 1FS9A 2RDZA 2ZAFA 4IRNA 4IV6A 4L38A 1SIRA 3BNGA 3B96A 3MMOA 2JBSA 1FS8A 4XVXA 4L1FA 4O5MA 2PG0A 4Q17A 2Z1QA 5K3JA 4KTOA 2J7AA 3X0YA 4Q1OA 3MKHA 3HWCA 3AFFA 3GM6A 3D9GA 1IVHA 3BNFA 3D9DA 4Q5BA 4Q5CA 2VIGA 3SWOA 1RX0A 3UU9A 3LGQA 4X28A 2E81A 3OWAA 4JEKA 3OWMA 2VR0A 1EGCA 3L1TA 5K3GA 2YYMA 2IX6A 4L3XA 3D6BA 3FCJA 2REHA 2EBAA 3SCEA 3D1IA 4ZXVA 4Q4UA 1T9GA 4U83A 1IS2A 1GU6A 3SXQA 1UKWA 2CX9A 3TTBA 4NXLA 4RM7A 4L3ZA 2DVLA 3RKHA 2YYKA 2RF7A 3SF6A 2UXWA 3P4TA 3MDDA 2YYGA 3FO3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BUC A;  3MDE A;  3OIB A;  2WBI A;  2A1T A;  1R2J A;  2IX5 A;  4L3Y A;  3R7K A;  3PFD A;  4DOY A;  2R0M A;  2D29 A;  3D9F A;  3NF4 A;  2YYL A;  1JQI A;  2C12 A;  3MPJ A;  5K3I A;  3X0X A;  4G5E A;  4N5F A;  1U8V A;  3II9 A;  3MPI A;  2JBR A;  4HR3 A;  2OR0 A;  4M9A A;  3EOM A;  5K3H A;  1SIQ A;  4Q0T A;  1QDB A;  1OAH A;  3S7W A;  3LG1 A;  4ZYJ A;  2YYJ A;  1EGD A;  3UBR A;  3M9V A;  1WS9 A;  3F29 A;  1FS7 A;  4W9U A;  2E80 A;  2JBT A;  4OO2 A;  2FON A;  3AFE A;  2C0U A;  3BNH A;  3MXL A;  1W07 A;  4X28 C;  4KCF A;  3D9E A;  2JIF A;  3TOR A;  4P13 A;  2R0N A;  1UDY A;  1EGE A;  3GNC A;  2RFQ A;  2ZO5 A;  2DDH A;  2OT4 A;  2YYI A;  3EON A;  3BNJ A;  3GQT A;  4WJY A;  1FS9 A;  2RDZ A;  2ZAF A;  4IRN A;  4IV6 A;  4L38 A;  1SIR A;  3BNG A;  3B96 A;  3MMO A;  2JBS A;  1FS8 A;  4XVX A;  4L1F A;  4O5M A;  2PG0 A;  4Q17 A;  2Z1Q A;  5K3J A;  4KTO A;  2J7A A;  3X0Y A;  4Q1O A;  3MKH A;  3HWC A;  3AFF A;  3GM6 A;  3D9G A;  1IVH A;  3BNF A;  3D9D A;  4Q5B A;  4Q5C A;  2VIG A;  3SWO A;  1RX0 A;  3UU9 A;  3LGQ A;  4X28 A;  2E81 A;  3OWA A;  4JEK A;  3OWM A;  2VR0 A;  1EGC A;  3L1T A;  5K3G A;  2YYM A;  2IX6 A;  4L3X A;  3D6B A;  3FCJ A;  2REH A;  2EBA A;  3SCE A;  3D1I A;  4ZXV A;  4Q4U A;  1T9G A;  4U83 A;  1IS2 A;  1GU6 A;  3SXQ A;  1UKW A;  2CX9 A;  3TTB A;  4NXL A;  4RM7 A;  4L3Z A;  2DVL A;  3RKH A;  2YYK A;  2RF7 A;  3SF6 A;  2UXW A;  3P4T A;  3MDD A;  2YYG A;  3FO3 A; 
#chains in the Genus database with same CATH topology
 2EC5 A;  1BUC A;  3MDE A;  3OIB A;  1Y8P A;  2A1T A;  1R2J A;  2IX5 A;  2WBI A;  4L3Y A;  3PFD A;  3R7K A;  4DOY A;  2R0M A;  2D29 A;  2BU5 A;  2PO4 A;  3D9F A;  3NF4 A;  5M4P A;  2YYL A;  1JQI A;  2C12 A;  3MPJ A;  4LQQ B;  2R03 A;  5K3I A;  2YGW A;  1GKX A;  3X0X A;  2BU6 A;  2CJ6 A;  4G5E A;  4N5F A;  1K93 A;  1XFW A;  4AKH A;  5EZ3 A;  4MPC A;  5BRK A;  1GJV A;  4LQS B;  1U8V A;  3U33 A;  2QR4 A;  4MP7 A;  4E02 A;  1SK6 A;  3KML A;  3II9 A;  1XFY A;  3MPI A;  4FF4 A;  1K8T A;  2FP1 A;  1RJ1 A;  1XFX A;  2JBR A;  4HR3 A;  2OR0 A;  4M9A A;  2OEV A;  3EOM A;  1SIQ A;  5K3H A;  4Q0T A;  1QDB A;  3X29 A;  1XFZ A;  2XS1 A;  1OAH A;  5B6B A;  3S7W A;  5M4M A;  3LG1 A;  4AI6 A;  4ZYJ A;  2YYJ A;  1EGD A;  3UBR A;  1JM6 A;  2EBH X;  1WS9 A;  3M9V A;  2E0A A;  3F29 A;  4FF1 A;  1FS7 A;  4W9U A;  1Y8O A;  2E80 A;  2JBT A;  1XFV A;  2AZE A;  2CJ8 A;  2FON A;  2ZDX A;  3AFE A;  4JIZ A;  4OO2 A;  2C0U A;  3BNH A;  3MXL A;  1W07 A;  4X28 C;  4E01 A;  5J71 A;  4KCF A;  4MPE A;  3D9E A;  3Q23 A;  2JIF A;  2FP2 A;  3TOR A;  4P13 A;  2XQR B;  1X8Z A;  2R0N A;  1UDY A;  1EGE A;  3GNC A;  2RFQ A;  4J1V A;  1R3B A;  1PI1 A;  4MPN A;  2Q8H A;  2ZO5 A;  2DDH A;  2OT4 A;  3VKG A;  2BU7 A;  2OEX A;  2YYI A;  2VF1 A;  3BNJ A;  1SC5 A;  3EON A;  1RJ4 A;  3GQT A;  4WJY A;  1FS9 A;  4H85 A;  4FZ4 A;  2RDZ A;  2ZAF A;  2XS8 A;  4IRN A;  4IV6 A;  3TZ2 A;  5J6A A;  4G97 A;  4L38 A;  1SIR A;  3Q0A A;  3BNG A;  4H81 A;  2ZKJ A;  3B96 A;  2PNR A;  2Q8G A;  3MMO A;  4QIC A;  5M4N A;  2JBS A;  1FS8 A;  2CJ7 A;  5BRM A;  4XVX A;  2Q8I A;  5M4K A;  4L1F A;  4O5M A;  3Q24 A;  2PG0 A;  4Q17 A;  4F0X A;  2Z1Q A;  5K3J A;  4KTO A;  2J7A A;  1GKZ A;  2LFW A;  3C3L A;  3X0Y A;  1Y0V A;  4E00 A;  4H7Q A;  4Q1O A;  3MKH A;  3HWC A;  2GBB A;  3C46 A;  2F6L A;  3N0R A;  4V26 A;  3AFF A;  3GM6 A;  3D9G A;  1S26 A;  2BU8 A;  3CRL A;  1IVH A;  2BU2 A;  3BNF A;  4HKS A;  3TZ0 A;  3D9D A;  4Q5B A;  1PK0 A;  4P79 A;  1XG2 B;  3TZ4 A;  5GJV E;  4Q5C A;  2VIG A;  1X91 A;  4FF2 A;  3SWO A;  1RX0 A;  3D2R A;  4MP2 A;  3UU9 A;  4AKI A;  3LGQ A;  4X28 A;  2E81 A;  5B5W A;  3VKH A;  2AO2 A;  3Q22 A;  3OWA A;  4JEK A;  3CRK A;  3OWM A;  1X90 A;  2VR0 A;  1EGC A;  2HJN A;  3L1T A;  5K3G A;  2YYM A;  2ZDY A;  2IX6 A;  4L3X A;  4KSA A;  2BTZ A;  2CJ4 A;  1Y8N A;  2REH A;  3D6B A;  2R02 A;  2EBA A;  3FCJ A;  5B5V A;  3SCE A;  3D1I A;  4KSF A;  4ZXV A;  4Q4U A;  3VAD A;  1T9G A;  4U83 A;  2R05 A;  1RP3 A;  1IS2 A;  1GU6 A;  2OJQ A;  4V25 A;  2Q8F A;  1UKW A;  2CX9 A;  3SXQ A;  3TTB A;  4FF3 A;  4KS9 A;  4NXL A;  2CJ5 A;  1K90 A;  1LVC A;  1XFU A;  4RM7 A;  3TZ5 A;  3DJL A;  4L3Z A;  2DVL A;  3CE2 A;  3RKH A;  2YYK A;  2RF7 A;  4DZY A;  3SF6 A;  2UXW A;  3P4T A;  4JIO A;  2EBF X;  3MDD A;  3C2P A;  4HKR A;  2YYG A;  3FO3 A;  4AKG A;  5GJW E; 
#chains in the Genus database with same CATH homology
 1BUC A;  3MDE A;  3OIB A;  2WBI A;  2A1T A;  1R2J A;  2IX5 A;  4L3Y A;  3R7K A;  3PFD A;  4DOY A;  2R0M A;  2D29 A;  3D9F A;  3NF4 A;  2YYL A;  1JQI A;  2C12 A;  3MPJ A;  5K3I A;  3X0X A;  4G5E A;  4N5F A;  1U8V A;  3II9 A;  3MPI A;  2JBR A;  4HR3 A;  2OR0 A;  4M9A A;  3EOM A;  5K3H A;  1SIQ A;  4Q0T A;  1QDB A;  1OAH A;  3S7W A;  3LG1 A;  4ZYJ A;  2YYJ A;  1EGD A;  3UBR A;  3M9V A;  1WS9 A;  3F29 A;  1FS7 A;  4W9U A;  2E80 A;  2JBT A;  4OO2 A;  2FON A;  3AFE A;  2C0U A;  3BNH A;  3MXL A;  1W07 A;  4X28 C;  4KCF A;  3D9E A;  2JIF A;  3TOR A;  4P13 A;  2R0N A;  1UDY A;  1EGE A;  3GNC A;  2RFQ A;  2ZO5 A;  2DDH A;  2OT4 A;  2YYI A;  3EON A;  3BNJ A;  3GQT A;  4WJY A;  1FS9 A;  2RDZ A;  2ZAF A;  4IRN A;  4IV6 A;  4L38 A;  1SIR A;  3BNG A;  3B96 A;  3MMO A;  2JBS A;  1FS8 A;  4XVX A;  4L1F A;  4O5M A;  2PG0 A;  4Q17 A;  2Z1Q A;  5K3J A;  4KTO A;  2J7A A;  3X0Y A;  4Q1O A;  3MKH A;  3HWC A;  3AFF A;  3GM6 A;  3D9G A;  1IVH A;  3BNF A;  3D9D A;  4Q5B A;  4Q5C A;  2VIG A;  3SWO A;  1RX0 A;  3UU9 A;  3LGQ A;  4X28 A;  2E81 A;  3OWA A;  4JEK A;  3OWM A;  2VR0 A;  1EGC A;  3L1T A;  5K3G A;  2YYM A;  2IX6 A;  4L3X A;  3D6B A;  3FCJ A;  2REH A;  2EBA A;  3SCE A;  3D1I A;  4ZXV A;  4Q4U A;  1T9G A;  4U83 A;  1IS2 A;  1GU6 A;  3SXQ A;  1UKW A;  2CX9 A;  3TTB A;  4NXL A;  4RM7 A;  4L3Z A;  2DVL A;  3RKH A;  2YYK A;  2RF7 A;  3SF6 A;  2UXW A;  3P4T A;  3MDD A;  2YYG A;  3FO3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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