1LVCA

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 2' deoxy, 3' anthraniloyl atp
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
507
structure length
485
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords calmodulin-sensitive adenylate cyclase
publication title Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
pubmed doi rcsb
source organism Bacillus anthracis
total genus 134
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2002-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1lvcA03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1lvcA02
1K90A 1XFUA 1XFZA 1LVCA 1ZOTA 1XFYA 1XFXA 1K93A 1Y0VA 1YRTA 2COLA 1PK0A 1SK6A 1XFVA 1S26A 1XFWA 1K8TA 1YRUA
chains in the Genus database with same CATH superfamily
2VF1A 2EBAA 3TORA 3TZ0A 2JIFA 3MMOA 3C2PA 3MPIA 3M9VA 2YYMA 4E00A 2C12A 2J7AA 4Q17A 4M9AA 1FS8A 2EBHX 2QR4A 2A1TA 3MXLA 1RP3A 2UXWA 4FF1A 2YYKA 2R05A 3D9EA 1GKXA 1Y0VA 3OIBA 3BNJA 2BU5A 4QICA 1XFVA 1JM6A 1S26A 4Q5BA 1K93A 5J71A 4Q4UA 4AI6A 2R0MA 2YYJA 1GKZA 2RFQA 2Q8IA 4LQSB 2AO2A 2PNRA 2FP1A 4FF3A 3X29A 2YYIA 4G97A 4MP7A 4N5FA 1UDYA 1GU6A 1T9GA 2JBSA 3D9FA 4KTOA 3MPJA 3MDEA 4ZYJA 1U8VA 1X91A 4H7QA 1YRUA 4J1VA 3F29A 3GM6A 5M4NA 1ZOTA 2AZEA 3S7WA 2BTZA 1SC5A 3FO3A 1SIQA 2CJ7A 2F6LA 1PI1A 1SK6A 1XG2B 2OJQA 2EBFX 3BNHA 3CE2A 2CJ5A 2CX9A 1RJ1A 1IVHA 2GBBA 1LVCA 2ZKJA 3AFFA 3D2RA 4L3XA 4L3ZA 3LGQA 3UU9A 3Q22A 2LFWA 4H81A 1EGDA 4MPNA 4JEKA 1X8ZA 1PK0A 2DVLA 3X0XA 5BRMA 2VR0A 1XFUA 1Y8OA 1RX0A 4HKSA 2R03A 4IRNA 2CJ8A 4F0XA 2D29A 2DDHA 2OEXA 3II9A 5GJVE 2FONA 3GNCA 5B5VA 2BU8A 4O5MA 2ZDXA 3UBRA 1XFYA 2R02A 3KMLA 1UKWA 2CJ6A 2HJNA 1WS9A 2YGWA 2VIGA 3SXQA 2IX5A 4V26A 3TTBA 4Q5CA 2ZAFA 4E01A 4RM7A 4KSAA 4L1FA 1X90A 2JBRA 1FS9A 4OO2A 4Q0TA 2Q8HA 5BRKA 2IX6A 2YYLA 3L1TA 3GQTA 4HKRA 3CRLA 4P13A 5B5WA 2PG0A 3TZ4A 4MPEA 4XVXA 1K90A 4H85A 1XFZA 2Z1QA 2ZDYA 4HR3A 4DOYA 5M4PA 1BUCA 5K3HA 4NXLA 1EGCA 4KCFA 5K3JA 2YYGA 3OWAA 4FF2A 1JQIA 2JBTA 3NF4A 2PO4A 4IV6A 2EC5A 3SF6A 5B6BA 2REHA 4AKHA 1FS7A 5K3GA 5M4KA 3C46A 3VADA 5K3IA 4G5EA 4V25A 2BU2A 3MDDA 2XS8A 3D9DA 1K8TA 1GJVA 4U83A 5GJWE 3D1IA 4LQQB 2E0AA 4ZXVA 2ZO5A 4Q1OA 4JIZA 2OT4A 2OR0A 1W07A 3B96A 3MKHA 3Q0AA 2BU7A 4MP2A 1Y8NA 4W9UA 4MPCA 4DZYA 3C3LA 3BNFA 3EOMA 2Q8FA 3VKGA 3N0RA 4KS9A 2XS1A 4X28A 3RKHA 1QDBA 3OWMA 3FCJA 2RF7A 1OAHA 1EGEA 4E02A 2CJ4A 4FZ4A 3BNGA 3HWCA 3AFEA 4X28C 1YRTA 2XQRB 3VKHA 1Y8PA 2BU6A 3LG1A 4JIOA 4KSFA 3Q23A 2Q8GA 1RJ4A 1SIRA 1R3BA 2C0UA 3CRKA 3R7KA 1R2JA 2E80A 1IS2A 3SCEA 4AKGA 2RDZA 3TZ2A 3P4TA 4P79A 5M4MA 3D9GA 2COLA 1XFWA 2FP2A 3D6BA 4L3YA 4WJYA 3X0YA 1XFXA 3Q24A 3SWOA 2OEVA 3TZ5A 2E81A 2R0NA 3PFDA 2WBIA 4AKIA 3EONA 5J6AA 4L38A 4FF4A
chains in the Genus database with same CATH topology
2VF1A 4KSAA 1ZOTA 2AZEA 3C3LA 1SC5A 3C2PA 4HKRA 2F6LA 3VKGA 1SK6A 3N0RA 4KS9A 3CE2A 2EBFX 2EBHX 2QR4A 1K90A 2GBBA 1XFZA 1LVCA 1RP3A 3Q22A 4FF1A 4FZ4A 2LFWA 1Y0VA 1YRTA 4FF2A 4QICA 3VKHA 1PK0A 1XFVA 1S26A 2EC5A 2PO4A 1K93A 4KSFA 3Q23A 1XFUA 4AKHA 4AKGA 4HKSA 3C46A 4AI6A 4F0XA 5GJVE 2AO2A 4P79A 2COLA 2FP1A 4FF3A 3X29A 1XFWA 1K8TA 4G97A 2FP2A 5GJWE 1XFYA 1XFXA 3KMLA 3Q24A 2YGWA 4AKIA 3Q0AA 1YRUA 4FF4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K90 A;  1XFU A;  1XFZ A;  1LVC A;  1ZOT A;  1XFY A;  1XFX A;  1K93 A;  1Y0V A;  1YRT A;  2COL A;  1PK0 A;  1SK6 A;  1XFV A;  1S26 A;  1XFW A;  1K8T A;  1YRU A; 
#chains in the Genus database with same CATH topology
 2VF1 A;  2EBA A;  3TOR A;  3TZ0 A;  2JIF A;  3MMO A;  3C2P A;  3MPI A;  3M9V A;  2YYM A;  4E00 A;  2C12 A;  2J7A A;  4Q17 A;  4M9A A;  1FS8 A;  2EBH X;  2QR4 A;  2A1T A;  3MXL A;  1RP3 A;  2UXW A;  4FF1 A;  2YYK A;  2R05 A;  3D9E A;  1GKX A;  1Y0V A;  3OIB A;  3BNJ A;  2BU5 A;  4QIC A;  1XFV A;  1JM6 A;  1S26 A;  4Q5B A;  1K93 A;  5J71 A;  4Q4U A;  4AI6 A;  2R0M A;  2YYJ A;  1GKZ A;  2RFQ A;  2Q8I A;  4LQS B;  2AO2 A;  2PNR A;  2FP1 A;  4FF3 A;  3X29 A;  2YYI A;  4G97 A;  4MP7 A;  4N5F A;  1UDY A;  1GU6 A;  1T9G A;  2JBS A;  3D9F A;  4KTO A;  3MPJ A;  3MDE A;  4ZYJ A;  1U8V A;  1X91 A;  4H7Q A;  1YRU A;  4J1V A;  3F29 A;  3GM6 A;  5M4N A;  1ZOT A;  2AZE A;  3S7W A;  2BTZ A;  1SC5 A;  3FO3 A;  1SIQ A;  2CJ7 A;  2F6L A;  1PI1 A;  1SK6 A;  1XG2 B;  2OJQ A;  2EBF X;  3BNH A;  3CE2 A;  2CJ5 A;  2CX9 A;  1RJ1 A;  1IVH A;  2GBB A;  1LVC A;  2ZKJ A;  3AFF A;  3D2R A;  4L3X A;  4L3Z A;  3LGQ A;  3UU9 A;  3Q22 A;  2LFW A;  4H81 A;  1EGD A;  4MPN A;  4JEK A;  1X8Z A;  1PK0 A;  2DVL A;  3X0X A;  5BRM A;  2VR0 A;  1XFU A;  1Y8O A;  1RX0 A;  4HKS A;  2R03 A;  4IRN A;  2CJ8 A;  4F0X A;  2D29 A;  2DDH A;  2OEX A;  3II9 A;  5GJV E;  2FON A;  3GNC A;  5B5V A;  2BU8 A;  4O5M A;  2ZDX A;  3UBR A;  1XFY A;  2R02 A;  3KML A;  1UKW A;  2CJ6 A;  2HJN A;  1WS9 A;  2YGW A;  2VIG A;  3SXQ A;  2IX5 A;  4V26 A;  3TTB A;  4Q5C A;  2ZAF A;  4E01 A;  4RM7 A;  4KSA A;  4L1F A;  1X90 A;  2JBR A;  1FS9 A;  4OO2 A;  4Q0T A;  2Q8H A;  5BRK A;  2IX6 A;  2YYL A;  3L1T A;  3GQT A;  4HKR A;  3CRL A;  4P13 A;  5B5W A;  2PG0 A;  3TZ4 A;  4MPE A;  4XVX A;  1K90 A;  4H85 A;  1XFZ A;  2Z1Q A;  2ZDY A;  4HR3 A;  4DOY A;  5M4P A;  1BUC A;  5K3H A;  4NXL A;  1EGC A;  4KCF A;  5K3J A;  2YYG A;  3OWA A;  4FF2 A;  1JQI A;  2JBT A;  3NF4 A;  2PO4 A;  4IV6 A;  2EC5 A;  3SF6 A;  5B6B A;  2REH A;  4AKH A;  1FS7 A;  5K3G A;  5M4K A;  3C46 A;  3VAD A;  5K3I A;  4G5E A;  4V25 A;  2BU2 A;  3MDD A;  2XS8 A;  3D9D A;  1K8T A;  1GJV A;  4U83 A;  5GJW E;  3D1I A;  4LQQ B;  2E0A A;  4ZXV A;  2ZO5 A;  4Q1O A;  4JIZ A;  2OT4 A;  2OR0 A;  1W07 A;  3B96 A;  3MKH A;  3Q0A A;  2BU7 A;  4MP2 A;  1Y8N A;  4W9U A;  4MPC A;  4DZY A;  3C3L A;  3BNF A;  3EOM A;  2Q8F A;  3VKG A;  3N0R A;  4KS9 A;  2XS1 A;  4X28 A;  3RKH A;  1QDB A;  3OWM A;  3FCJ A;  2RF7 A;  1OAH A;  1EGE A;  4E02 A;  2CJ4 A;  4FZ4 A;  3BNG A;  3HWC A;  3AFE A;  4X28 C;  1YRT A;  2XQR B;  3VKH A;  1Y8P A;  2BU6 A;  3LG1 A;  4JIO A;  4KSF A;  3Q23 A;  2Q8G A;  1RJ4 A;  1SIR A;  1R3B A;  2C0U A;  3CRK A;  3R7K A;  1R2J A;  2E80 A;  1IS2 A;  3SCE A;  4AKG A;  2RDZ A;  3TZ2 A;  3P4T A;  4P79 A;  5M4M A;  3D9G A;  2COL A;  1XFW A;  2FP2 A;  3D6B A;  4L3Y A;  4WJY A;  3X0Y A;  1XFX A;  3Q24 A;  3SWO A;  2OEV A;  3TZ5 A;  2E81 A;  2R0N A;  3PFD A;  2WBI A;  4AKI A;  3EON A;  5J6A A;  4L38 A;  4FF4 A; 
#chains in the Genus database with same CATH homology
 2VF1 A;  4KSA A;  1ZOT A;  2AZE A;  3C3L A;  1SC5 A;  3C2P A;  4HKR A;  2F6L A;  3VKG A;  1SK6 A;  3N0R A;  4KS9 A;  3CE2 A;  2EBF X;  2EBH X;  2QR4 A;  1K90 A;  2GBB A;  1XFZ A;  1LVC A;  1RP3 A;  3Q22 A;  4FF1 A;  4FZ4 A;  2LFW A;  1Y0V A;  1YRT A;  4FF2 A;  4QIC A;  3VKH A;  1PK0 A;  1XFV A;  1S26 A;  2EC5 A;  2PO4 A;  1K93 A;  4KSF A;  3Q23 A;  1XFU A;  4AKH A;  4AKG A;  4HKS A;  3C46 A;  4AI6 A;  4F0X A;  5GJV E;  2AO2 A;  4P79 A;  2COL A;  2FP1 A;  4FF3 A;  3X29 A;  1XFW A;  1K8T A;  4G97 A;  2FP2 A;  5GJW E;  1XFY A;  1XFX A;  3KML A;  3Q24 A;  2YGW A;  4AKI A;  3Q0A A;  1YRU A;  4FF4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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