1LVCA

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 2' deoxy, 3' anthraniloyl atp
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
507
structure length
485
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords calmodulin-sensitive adenylate cyclase
publication title Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
pubmed doi rcsb
source organism Bacillus anthracis
molecule tags Lyase
total genus 134
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2002-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1lvcA03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1lvcA02
1SK6A 1XFXA 1Y0VA 2COLA 1K93A 1YRTA 1XFUA 1XFYA 1ZOTA 1S26A 1XFVA 1YRUA 1K8TA 1K90A 1XFZA 1PK0A 1LVCA 1XFWA
chains in the Genus database with same CATH superfamily
2CJ8A 1GJVA 2R0NA 2RDZA 1IS2A 2RFQA 3D9GA 4MPEA 4XVXA 3VKHA 5M4NA 3OWAA 3SXQA 2CJ7A 5M4KA 3R7KA 4G97A 1FS8A 4IV6A 3TORA 3X0YA 4Q5BA 3II9A 4OO2A 4Q4UA 2DVLA 2EBHX 4MPNA 1GU6A 2FP1A 3TZ2A 4DOYA 1SIRA 4FZ4A 1RJ1A 3OIBA 2Q8IA 2COLA 4E00A 1EGEA 1SC5A 3CRLA 1T9GA 2E80A 3B96A 4FF3A 1BUCA 3KMLA 3VADA 4L3XA 5BRMA 1RP3A 1FS9A 2CJ6A 2YYLA 2JBSA 4HR3A 2GBBA 2PNRA 4HKSA 4LQSB 4X28C 2Q8GA 3MDEA 3TTBA 3MPJA 1SK6A 4Q17A 3D9FA 3SF6A 3Q23A 3MDDA 4O5MA 3TZ0A 1U8VA 2FONA 4AKIA 4J1VA 1X8ZA 3GM6A 1S26A 4FF4A 3Q0AA 3S7WA 1XFZA 1PK0A 1Y8PA 2J7AA 1Y8NA 2OEVA 4QICA 4X28A 5GJWE 2REHA 2BTZA 1PI1A 1X91A 2R0MA 3SWOA 4AKGA 1UKWA 1EGDA 1UDYA 1WS9A 2R05A 1YRTA 4ZYJA 2OT4A 1K90A 1GKZA 2R02A 3F29A 5B5WA 1JM6A 4L3ZA 3EONA 2FP2A 3P4TA 2ZDYA 4IRNA 2PG0A 4MP7A 1XFUA 2OJQA 2R03A 3MXLA 1GKXA 4KTOA 2VR0A 2RF7A 2VF1A 2XS1A 1FS7A 3BNFA 5GJVE 2F6LA 5J6AA 3N0RA 2YYGA 4RM7A 4AKHA 3CRKA 3OWMA 4FF2A 2EBFX 3D6BA 3EOMA 4JIOA 2Q8FA 5BRKA 1K8TA 2YYKA 1YRUA 1LVCA 2UXWA 3D9EA 2BU6A 2AZEA 1R2JA 3HWCA 4W9UA 1QDBA 3RKHA 3AFFA 3SCEA 5K3IA 3Q24A 2CJ5A 4JEKA 4WJYA 2C12A 3Q22A 1RJ4A 3PFDA 3MKHA 4E02A 4DZYA 2ZDXA 2ZAFA 4L1FA 2BU2A 2OEXA 3D2RA 2YYJA 2YYMA 1IVHA 3TZ5A 1Y8OA 2HJNA 2OR0A 2QR4A 4LQQB 2WBIA 1SIQA 3BNHA 4JIZA 3LGQA 2BU7A 4KSFA 3C46A 4MP2A 1X90A 2A1TA 3FCJA 3VKGA 2IX5A 2YYIA 4M9AA 1ZOTA 2BU5A 2C0UA 3X0XA 4F0XA 2EBAA 1JQIA 2XS8A 5B5VA 2ZO5A 2CX9A 3BNJA 3AFEA 2IX6A 2JIFA 4FF1A 4H7QA 2VIGA 4P79A 2XQRB 4L38A 1OAHA 5K3GA 2JBTA 1RX0A 3D9DA 3NF4A 4G5EA 4MPCA 1K93A 2LFWA 3UU9A 4Q0TA 2E0AA 2YGWA 3D1IA 3L1TA 4KS9A 5M4MA 4AI6A 3MMOA 4NXLA 2BU8A 2DDHA 1R3BA 2Z1QA 3M9VA 5B6BA 3X29A 5M4PA 4H85A 1XFYA 1XFVA 2CJ4A 4N5FA 2AO2A 5K3JA 5J71A 2Q8HA 4U83A 1XG2B 1XFXA 3MPIA 4Q5CA 4E01A 1EGCA 2D29A 3LG1A 2PO4A 3UBRA 3CE2A 3C3LA 4KCFA 4V26A 4P13A 3GNCA 4L3YA 1Y0VA 4V25A 3TZ4A 1XFWA 3BNGA 1W07A 3C2PA 2EC5A 3FO3A 2JBRA 4Q1OA 4H81A 4ZXVA 3GQTA 4HKRA 5K3HA 4KSAA 2ZKJA 2E81A
chains in the Genus database with same CATH topology
1SK6A 3Q24A 3Q23A 3Q22A 1K93A 2LFWA 4AKIA 3VKHA 4KS9A 2YGWA 4FF4A 1S26A 4AI6A 3Q0AA 1XFZA 1PK0A 4G97A 4QICA 5GJWE 2QR4A 3X29A 4AKGA 1YRTA 2EBHX 1XFYA 1XFVA 2AO2A 2FP1A 1K90A 4KSFA 3C46A 1XFXA 2FP2A 4FZ4A 3VKGA 2COLA 2PO4A 4HKSA 3CE2A 3C3LA 1XFUA 1ZOTA 1SC5A 4F0XA 2VF1A 1Y0VA 5GJVE 3C2PA 1XFWA 2F6LA 4FF3A 2EC5A 3N0RA 4AKHA 3KMLA 4FF2A 1RP3A 4FF1A 2EBFX 4HKRA 2GBBA 1YRUA 1K8TA 4KSAA 4P79A 1LVCA 2AZEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SK6 A;  1XFX A;  1Y0V A;  2COL A;  1K93 A;  1YRT A;  1XFU A;  1XFY A;  1ZOT A;  1S26 A;  1XFV A;  1YRU A;  1K8T A;  1K90 A;  1XFZ A;  1PK0 A;  1LVC A;  1XFW A; 
#chains in the Genus database with same CATH topology
 2CJ8 A;  1GJV A;  2R0N A;  2RDZ A;  1IS2 A;  2RFQ A;  3D9G A;  4MPE A;  4XVX A;  3VKH A;  5M4N A;  3OWA A;  3SXQ A;  2CJ7 A;  5M4K A;  3R7K A;  4G97 A;  1FS8 A;  4IV6 A;  3TOR A;  3X0Y A;  4Q5B A;  3II9 A;  4OO2 A;  4Q4U A;  2DVL A;  2EBH X;  4MPN A;  1GU6 A;  2FP1 A;  3TZ2 A;  4DOY A;  1SIR A;  4FZ4 A;  1RJ1 A;  3OIB A;  2Q8I A;  2COL A;  4E00 A;  1EGE A;  1SC5 A;  3CRL A;  1T9G A;  2E80 A;  3B96 A;  4FF3 A;  1BUC A;  3KML A;  3VAD A;  4L3X A;  5BRM A;  1RP3 A;  1FS9 A;  2CJ6 A;  2YYL A;  2JBS A;  4HR3 A;  2GBB A;  2PNR A;  4HKS A;  4LQS B;  4X28 C;  2Q8G A;  3MDE A;  3TTB A;  3MPJ A;  1SK6 A;  4Q17 A;  3D9F A;  3SF6 A;  3Q23 A;  3MDD A;  4O5M A;  3TZ0 A;  1U8V A;  2FON A;  4AKI A;  4J1V A;  1X8Z A;  3GM6 A;  1S26 A;  4FF4 A;  3Q0A A;  3S7W A;  1XFZ A;  1PK0 A;  1Y8P A;  2J7A A;  1Y8N A;  2OEV A;  4QIC A;  4X28 A;  5GJW E;  2REH A;  2BTZ A;  1PI1 A;  1X91 A;  2R0M A;  3SWO A;  4AKG A;  1UKW A;  1EGD A;  1UDY A;  1WS9 A;  2R05 A;  1YRT A;  4ZYJ A;  2OT4 A;  1K90 A;  1GKZ A;  2R02 A;  3F29 A;  5B5W A;  1JM6 A;  4L3Z A;  3EON A;  2FP2 A;  3P4T A;  2ZDY A;  4IRN A;  2PG0 A;  4MP7 A;  1XFU A;  2OJQ A;  2R03 A;  3MXL A;  1GKX A;  4KTO A;  2VR0 A;  2RF7 A;  2VF1 A;  2XS1 A;  1FS7 A;  3BNF A;  5GJV E;  2F6L A;  5J6A A;  3N0R A;  2YYG A;  4RM7 A;  4AKH A;  3CRK A;  3OWM A;  4FF2 A;  2EBF X;  3D6B A;  3EOM A;  4JIO A;  2Q8F A;  5BRK A;  1K8T A;  2YYK A;  1YRU A;  1LVC A;  2UXW A;  3D9E A;  2BU6 A;  2AZE A;  1R2J A;  3HWC A;  4W9U A;  1QDB A;  3RKH A;  3AFF A;  3SCE A;  5K3I A;  3Q24 A;  2CJ5 A;  4JEK A;  4WJY A;  2C12 A;  3Q22 A;  1RJ4 A;  3PFD A;  3MKH A;  4E02 A;  4DZY A;  2ZDX A;  2ZAF A;  4L1F A;  2BU2 A;  2OEX A;  3D2R A;  2YYJ A;  2YYM A;  1IVH A;  3TZ5 A;  1Y8O A;  2HJN A;  2OR0 A;  2QR4 A;  4LQQ B;  2WBI A;  1SIQ A;  3BNH A;  4JIZ A;  3LGQ A;  2BU7 A;  4KSF A;  3C46 A;  4MP2 A;  1X90 A;  2A1T A;  3FCJ A;  3VKG A;  2IX5 A;  2YYI A;  4M9A A;  1ZOT A;  2BU5 A;  2C0U A;  3X0X A;  4F0X A;  2EBA A;  1JQI A;  2XS8 A;  5B5V A;  2ZO5 A;  2CX9 A;  3BNJ A;  3AFE A;  2IX6 A;  2JIF A;  4FF1 A;  4H7Q A;  2VIG A;  4P79 A;  2XQR B;  4L38 A;  1OAH A;  5K3G A;  2JBT A;  1RX0 A;  3D9D A;  3NF4 A;  4G5E A;  4MPC A;  1K93 A;  2LFW A;  3UU9 A;  4Q0T A;  2E0A A;  2YGW A;  3D1I A;  3L1T A;  4KS9 A;  5M4M A;  4AI6 A;  3MMO A;  4NXL A;  2BU8 A;  2DDH A;  1R3B A;  2Z1Q A;  3M9V A;  5B6B A;  3X29 A;  5M4P A;  4H85 A;  1XFY A;  1XFV A;  2CJ4 A;  4N5F A;  2AO2 A;  5K3J A;  5J71 A;  2Q8H A;  4U83 A;  1XG2 B;  1XFX A;  3MPI A;  4Q5C A;  4E01 A;  1EGC A;  2D29 A;  3LG1 A;  2PO4 A;  3UBR A;  3CE2 A;  3C3L A;  4KCF A;  4V26 A;  4P13 A;  3GNC A;  4L3Y A;  1Y0V A;  4V25 A;  3TZ4 A;  1XFW A;  3BNG A;  1W07 A;  3C2P A;  2EC5 A;  3FO3 A;  2JBR A;  4Q1O A;  4H81 A;  4ZXV A;  3GQT A;  4HKR A;  5K3H A;  4KSA A;  2ZKJ A;  2E81 A; 
#chains in the Genus database with same CATH homology
 1SK6 A;  3Q24 A;  3Q23 A;  3Q22 A;  1K93 A;  2LFW A;  4AKI A;  3VKH A;  4KS9 A;  2YGW A;  4FF4 A;  1S26 A;  4AI6 A;  3Q0A A;  1XFZ A;  1PK0 A;  4G97 A;  4QIC A;  5GJW E;  2QR4 A;  3X29 A;  4AKG A;  1YRT A;  2EBH X;  1XFY A;  1XFV A;  2AO2 A;  2FP1 A;  1K90 A;  4KSF A;  3C46 A;  1XFX A;  2FP2 A;  4FZ4 A;  3VKG A;  2COL A;  2PO4 A;  4HKS A;  3CE2 A;  3C3L A;  1XFU A;  1ZOT A;  1SC5 A;  4F0X A;  2VF1 A;  1Y0V A;  5GJV E;  3C2P A;  1XFW A;  2F6L A;  4FF3 A;  2EC5 A;  3N0R A;  4AKH A;  3KML A;  4FF2 A;  1RP3 A;  4FF1 A;  2EBF X;  4HKR A;  2GBB A;  1YRU A;  1K8T A;  4KSA A;  4P79 A;  1LVC A;  2AZE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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