1EGDA

Structure of t255e, e376g mutant of human medium chain acyl-coa dehydrogenase
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
387
structure length
387
Chain Sequence
LGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKERPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYGGTSQIQRLIVAREHIDKYKN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
pubmed doi rcsb
molecule tags Electron transfer
source organism Homo sapiens
molecule keywords MEDIUM CHAIN ACYL-COA DEHYDROGENASE
total genus 148
structure length 387
sequence length 387
chains with identical sequence B, C, D
ec nomenclature ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date 1996-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1egdA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1egdA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1egdA02
3EONA 3MPJA 2E80A 4L3XA 4Q17A 3BNJA 1UKWA 3M9VA 2UXWA 2YYJA 3LG1A 2JBSA 1IS2A 3OIBA 2VR0A 1JQIA 2YYKA 2REHA 2YYLA 4Q5BA 3SCEA 1EGEA 3PFDA 3BNFA 4IRNA 4L1FA 2IX6A 3D9FA 1FS8A 2OT4A 5K3HA 4L3ZA 2YYMA 4Q4UA 3UBRA 4U83A 4N5FA 4L3YA 1RX0A 2R0NA 3D6BA 3NF4A 4DOYA 2E81A 3FO3A 1EGCA 4X28A 3GM6A 2RDZA 1SIRA 3D9EA 1BUCA 4OO2A 4M9AA 4RM7A 3MXLA 4G5EA 1FS9A 3AFEA 3P4TA 3LGQA 2RF7A 4HR3A 3GQTA 3BNGA 3HWCA 2DVLA 1IVHA 4KTOA 5K3IA 3D9DA 4Q5CA 2Z1QA 1U8VA 4L38A 3BNHA 3EOMA 3MMOA 3MDEA 2C12A 1UDYA 2YYGA 4ZXVA 3RKHA 3UU9A 2OR0A 5K3GA 1EGDA 1OAHA 3MPIA 2JBRA 2FONA 3D1IA 2A1TA 2JIFA 2C0UA 2R0MA 3X0XA 3X0YA 4ZYJA 2ZO5A 3B96A 2VIGA 3FCJA 3R7KA 1FS7A 3SF6A 1WS9A 2CX9A 1GU6A 2PG0A 4X28C 3OWAA 1QDBA 4WJYA 2RFQA 5K3JA 3TORA 3F29A 3MKHA 4P13A 2DDHA 1W07A 3MDDA 4W9UA 3OWMA 2IX5A 3TTBA 2JBTA 3SXQA 4NXLA 4XVXA 2WBIA 3D9GA 1SIQA 2ZAFA 4JEKA 3II9A 4Q1OA 3SWOA 3S7WA 4IV6A 2J7AA 1R2JA 1T9GA 2D29A 4KCFA 3AFFA 4O5MA 3L1TA 4Q0TA 2EBAA 3GNCA 2YYIA
chains in the Genus database with same CATH superfamily
3EONA 1SC5A 3DJLA 3MPJA 2E80A 4L3XA 4Q17A 2R02A 1UKWA 3M9VA 3BNJA 2LFWA 2QR4A 1RP3A 1S26A 2EBHX 2UXWA 2YYJA 2ZDXA 2JBSA 1IS2A 3OIBA 2VR0A 1JQIA 1R3BA 2REHA 2YYKA 3KMLA 4JIOA 3C46A 4FF3A 3D2RA 2YYLA 2ZKJA 4Q5BA 3SCEA 1EGEA 3PFDA 3BNFA 2CJ5A 4H7QA 4IRNA 4L1FA 4HKSA 2CJ7A 2IX6A 3D9FA 1FS8A 2EC5A 2OT4A 5K3HA 2XQRB 2XS1A 1Y8NA 4L3ZA 4KSFA 2YYMA 4Q4UA 3UBRA 1PK0A 4MPNA 4U83A 4FF1A 4N5FA 4L3YA 1RX0A 2R0NA 3D6BA 3NF4A 4DOYA 2E81A 2BU8A 4F0XA 1RJ4A 3FO3A 1EGCA 5BRKA 4X28A 4H81A 3GM6A 2RDZA 1SIRA 2E0AA 4DZYA 3D9EA 2BU6A 1BUCA 4OO2A 1PI1A 4M9AA 2PO4A 4RM7A 4KSAA 3Q23A 3MXLA 4G5EA 1FS9A 3VADA 2OEXA 4G97A 3LG1A 3AFEA 3P4TA 1X90A 3LGQA 2BU7A 2RF7A 2BU2A 2FP1A 1SK6A 3TZ4A 5M4MA 4HR3A 3GQTA 3BNGA 3HWCA 2DVLA 4LQQB 4E01A 1X91A 3Q24A 1IVHA 4KTOA 5K3IA 4E02A 3D9DA 4MPCA 4AKHA 2CJ6A 3VKGA 1K8TA 4MPEA 2FP2A 1XFVA 4Q5CA 2BU5A 4JIZA 3C2PA 2Z1QA 1U8VA 2F6LA 3VKHA 4L38A 3BNHA 3EOMA 3MMOA 4H85A 3Q0AA 2BTZA 3MDEA 2CJ8A 4QICA 3Q22A 4AKIA 1Y8PA 4FF2A 5M4NA 2C12A 2AZEA 3CE2A 1UDYA 5GJVE 2OJQA 2YYGA 4ZXVA 1GKZA 4MP2A 3RKHA 2OR0A 4KS9A 3UU9A 5K3GA 1EGDA 2GBBA 4FZ4A 3X29A 1OAHA 3MPIA 2EBFX 1JM6A 3CRLA 2CJ4A 3TORA 3TZ0A 5EZ3A 2JBRA 2FONA 3D1IA 1XFYA 2A1TA 2JIFA 2C0UA 2Q8IA 2R0MA 3X0XA 3X0YA 2ZDYA 2OEVA 5J6AA 4ZYJA 4V25A 1GJVA 2ZO5A 2Q8FA 4AKGA 4LQSB 3B96A 2VIGA 4V26A 2Q8HA 3FCJA 3R7KA 4MP7A 3TZ5A 1FS7A 5J71A 3SF6A 1WS9A 2CX9A 1K93A 1GU6A 2PG0A 4X28C 1Y0VA 4HKRA 4J1VA 3OWAA 1QDBA 5M4KA 4WJYA 3CRKA 2RFQA 3C3LA 2AO2A 1GKXA 1XFXA 4E00A 2R03A 5K3JA 3U33A 1XFUA 1LVCA 3F29A 3MKHA 4P13A 2DDHA 1W07A 3MDDA 1K90A 4W9UA 1RJ1A 2R05A 1Y8OA 2YGWA 2IX5A 3OWMA 2Q8GA 3TTBA 3TZ2A 4AI6A 1X8ZA 2JBTA 3SXQA 4NXLA 4XVXA 5B6BA 2WBIA 2XS8A 3D9GA 1XFWA 2VF1A 1SIQA 2ZAFA 4JEKA 3II9A 2HJNA 3SWOA 2PNRA 4Q1OA 3S7WA 5B5WA 5BRMA 5M4PA 4IV6A 1XG2B 2J7AA 1R2JA 1T9GA 2D29A 4KCFA 3AFFA 4O5MA 3L1TA 3N0RA 2EBAA 3GNCA 4Q0TA 5B5VA 4FF4A 1XFZA 5GJWE 2YYIA 4P79A
chains in the Genus database with same CATH topology
3EONA 3MPJA 2E80A 4L3XA 4Q17A 3BNJA 1UKWA 3M9VA 2UXWA 2YYJA 3LG1A 2JBSA 1IS2A 3OIBA 2VR0A 1JQIA 2YYKA 2REHA 2YYLA 4Q5BA 3SCEA 1EGEA 3PFDA 3BNFA 4IRNA 4L1FA 2IX6A 3D9FA 1FS8A 2OT4A 5K3HA 4L3ZA 2YYMA 4Q4UA 3UBRA 4U83A 4N5FA 4L3YA 1RX0A 2R0NA 3D6BA 3NF4A 4DOYA 2E81A 3FO3A 1EGCA 4X28A 3GM6A 2RDZA 1SIRA 3D9EA 1BUCA 4OO2A 4M9AA 4RM7A 3MXLA 4G5EA 1FS9A 3AFEA 3P4TA 3LGQA 2RF7A 4HR3A 3GQTA 3BNGA 3HWCA 2DVLA 1IVHA 4KTOA 5K3IA 3D9DA 4Q5CA 2Z1QA 1U8VA 4L38A 3BNHA 3EOMA 3MMOA 3MDEA 2C12A 1UDYA 2YYGA 4ZXVA 3RKHA 3UU9A 2OR0A 5K3GA 1EGDA 1OAHA 3MPIA 2JBRA 2FONA 3D1IA 2A1TA 2JIFA 2C0UA 2R0MA 3X0XA 3X0YA 4ZYJA 2ZO5A 3B96A 2VIGA 3FCJA 3R7KA 1FS7A 3SF6A 1WS9A 2CX9A 1GU6A 2PG0A 4X28C 3OWAA 1QDBA 4WJYA 2RFQA 5K3JA 3TORA 3F29A 3MKHA 4P13A 2DDHA 1W07A 3MDDA 4W9UA 3OWMA 2IX5A 3TTBA 2JBTA 3SXQA 4NXLA 4XVXA 2WBIA 3D9GA 1SIQA 2ZAFA 4JEKA 3II9A 4Q1OA 3SWOA 3S7WA 4IV6A 2J7AA 1R2JA 1T9GA 2D29A 4KCFA 3AFFA 4O5MA 3L1TA 4Q0TA 2EBAA 3GNCA 2YYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EON A;  3MPJ A;  2E80 A;  4L3X A;  4Q17 A;  3BNJ A;  1UKW A;  3M9V A;  2UXW A;  2YYJ A;  3LG1 A;  2JBS A;  1IS2 A;  3OIB A;  2VR0 A;  1JQI A;  2YYK A;  2REH A;  2YYL A;  4Q5B A;  3SCE A;  1EGE A;  3PFD A;  3BNF A;  4IRN A;  4L1F A;  2IX6 A;  3D9F A;  1FS8 A;  2OT4 A;  5K3H A;  4L3Z A;  2YYM A;  4Q4U A;  3UBR A;  4U83 A;  4N5F A;  4L3Y A;  1RX0 A;  2R0N A;  3D6B A;  3NF4 A;  4DOY A;  2E81 A;  3FO3 A;  1EGC A;  4X28 A;  3GM6 A;  2RDZ A;  1SIR A;  3D9E A;  1BUC A;  4OO2 A;  4M9A A;  4RM7 A;  3MXL A;  4G5E A;  1FS9 A;  3AFE A;  3P4T A;  3LGQ A;  2RF7 A;  4HR3 A;  3GQT A;  3BNG A;  3HWC A;  2DVL A;  1IVH A;  4KTO A;  5K3I A;  3D9D A;  4Q5C A;  2Z1Q A;  1U8V A;  4L38 A;  3BNH A;  3EOM A;  3MMO A;  3MDE A;  2C12 A;  1UDY A;  2YYG A;  4ZXV A;  3RKH A;  3UU9 A;  2OR0 A;  5K3G A;  1EGD A;  1OAH A;  3MPI A;  2JBR A;  2FON A;  3D1I A;  2A1T A;  2JIF A;  2C0U A;  2R0M A;  3X0X A;  3X0Y A;  4ZYJ A;  2ZO5 A;  3B96 A;  2VIG A;  3FCJ A;  3R7K A;  1FS7 A;  3SF6 A;  1WS9 A;  2CX9 A;  1GU6 A;  2PG0 A;  4X28 C;  3OWA A;  1QDB A;  4WJY A;  2RFQ A;  5K3J A;  3TOR A;  3F29 A;  3MKH A;  4P13 A;  2DDH A;  1W07 A;  3MDD A;  4W9U A;  3OWM A;  2IX5 A;  3TTB A;  2JBT A;  3SXQ A;  4NXL A;  4XVX A;  2WBI A;  3D9G A;  1SIQ A;  2ZAF A;  4JEK A;  3II9 A;  4Q1O A;  3SWO A;  3S7W A;  4IV6 A;  2J7A A;  1R2J A;  1T9G A;  2D29 A;  4KCF A;  3AFF A;  4O5M A;  3L1T A;  4Q0T A;  2EBA A;  3GNC A;  2YYI A; 
#chains in the Genus database with same CATH topology
 3EON A;  1SC5 A;  3DJL A;  3MPJ A;  2E80 A;  4L3X A;  4Q17 A;  2R02 A;  1UKW A;  3M9V A;  3BNJ A;  2LFW A;  2QR4 A;  1RP3 A;  1S26 A;  2EBH X;  2UXW A;  2YYJ A;  2ZDX A;  2JBS A;  1IS2 A;  3OIB A;  2VR0 A;  1JQI A;  1R3B A;  2REH A;  2YYK A;  3KML A;  4JIO A;  3C46 A;  4FF3 A;  3D2R A;  2YYL A;  2ZKJ A;  4Q5B A;  3SCE A;  1EGE A;  3PFD A;  3BNF A;  2CJ5 A;  4H7Q A;  4IRN A;  4L1F A;  4HKS A;  2CJ7 A;  2IX6 A;  3D9F A;  1FS8 A;  2EC5 A;  2OT4 A;  5K3H A;  2XQR B;  2XS1 A;  1Y8N A;  4L3Z A;  4KSF A;  2YYM A;  4Q4U A;  3UBR A;  1PK0 A;  4MPN A;  4U83 A;  4FF1 A;  4N5F A;  4L3Y A;  1RX0 A;  2R0N A;  3D6B A;  3NF4 A;  4DOY A;  2E81 A;  2BU8 A;  4F0X A;  1RJ4 A;  3FO3 A;  1EGC A;  5BRK A;  4X28 A;  4H81 A;  3GM6 A;  2RDZ A;  1SIR A;  2E0A A;  4DZY A;  3D9E A;  2BU6 A;  1BUC A;  4OO2 A;  1PI1 A;  4M9A A;  2PO4 A;  4RM7 A;  4KSA A;  3Q23 A;  3MXL A;  4G5E A;  1FS9 A;  3VAD A;  2OEX A;  4G97 A;  3LG1 A;  3AFE A;  3P4T A;  1X90 A;  3LGQ A;  2BU7 A;  2RF7 A;  2BU2 A;  2FP1 A;  1SK6 A;  3TZ4 A;  5M4M A;  4HR3 A;  3GQT A;  3BNG A;  3HWC A;  2DVL A;  4LQQ B;  4E01 A;  1X91 A;  3Q24 A;  1IVH A;  4KTO A;  5K3I A;  4E02 A;  3D9D A;  4MPC A;  4AKH A;  2CJ6 A;  3VKG A;  1K8T A;  4MPE A;  2FP2 A;  1XFV A;  4Q5C A;  2BU5 A;  4JIZ A;  3C2P A;  2Z1Q A;  1U8V A;  2F6L A;  3VKH A;  4L38 A;  3BNH A;  3EOM A;  3MMO A;  4H85 A;  3Q0A A;  2BTZ A;  3MDE A;  2CJ8 A;  4QIC A;  3Q22 A;  4AKI A;  1Y8P A;  4FF2 A;  5M4N A;  2C12 A;  2AZE A;  3CE2 A;  1UDY A;  5GJV E;  2OJQ A;  2YYG A;  4ZXV A;  1GKZ A;  4MP2 A;  3RKH A;  2OR0 A;  4KS9 A;  3UU9 A;  5K3G A;  1EGD A;  2GBB A;  4FZ4 A;  3X29 A;  1OAH A;  3MPI A;  2EBF X;  1JM6 A;  3CRL A;  2CJ4 A;  3TOR A;  3TZ0 A;  5EZ3 A;  2JBR A;  2FON A;  3D1I A;  1XFY A;  2A1T A;  2JIF A;  2C0U A;  2Q8I A;  2R0M A;  3X0X A;  3X0Y A;  2ZDY A;  2OEV A;  5J6A A;  4ZYJ A;  4V25 A;  1GJV A;  2ZO5 A;  2Q8F A;  4AKG A;  4LQS B;  3B96 A;  2VIG A;  4V26 A;  2Q8H A;  3FCJ A;  3R7K A;  4MP7 A;  3TZ5 A;  1FS7 A;  5J71 A;  3SF6 A;  1WS9 A;  2CX9 A;  1K93 A;  1GU6 A;  2PG0 A;  4X28 C;  1Y0V A;  4HKR A;  4J1V A;  3OWA A;  1QDB A;  5M4K A;  4WJY A;  3CRK A;  2RFQ A;  3C3L A;  2AO2 A;  1GKX A;  1XFX A;  4E00 A;  2R03 A;  5K3J A;  3U33 A;  1XFU A;  1LVC A;  3F29 A;  3MKH A;  4P13 A;  2DDH A;  1W07 A;  3MDD A;  1K90 A;  4W9U A;  1RJ1 A;  2R05 A;  1Y8O A;  2YGW A;  2IX5 A;  3OWM A;  2Q8G A;  3TTB A;  3TZ2 A;  4AI6 A;  1X8Z A;  2JBT A;  3SXQ A;  4NXL A;  4XVX A;  5B6B A;  2WBI A;  2XS8 A;  3D9G A;  1XFW A;  2VF1 A;  1SIQ A;  2ZAF A;  4JEK A;  3II9 A;  2HJN A;  3SWO A;  2PNR A;  4Q1O A;  3S7W A;  5B5W A;  5BRM A;  5M4P A;  4IV6 A;  1XG2 B;  2J7A A;  1R2J A;  1T9G A;  2D29 A;  4KCF A;  3AFF A;  4O5M A;  3L1T A;  3N0R A;  2EBA A;  3GNC A;  4Q0T A;  5B5V A;  4FF4 A;  1XFZ A;  5GJW E;  2YYI A;  4P79 A; 
#chains in the Genus database with same CATH homology
 3EON A;  3MPJ A;  2E80 A;  4L3X A;  4Q17 A;  3BNJ A;  1UKW A;  3M9V A;  2UXW A;  2YYJ A;  3LG1 A;  2JBS A;  1IS2 A;  3OIB A;  2VR0 A;  1JQI A;  2YYK A;  2REH A;  2YYL A;  4Q5B A;  3SCE A;  1EGE A;  3PFD A;  3BNF A;  4IRN A;  4L1F A;  2IX6 A;  3D9F A;  1FS8 A;  2OT4 A;  5K3H A;  4L3Z A;  2YYM A;  4Q4U A;  3UBR A;  4U83 A;  4N5F A;  4L3Y A;  1RX0 A;  2R0N A;  3D6B A;  3NF4 A;  4DOY A;  2E81 A;  3FO3 A;  1EGC A;  4X28 A;  3GM6 A;  2RDZ A;  1SIR A;  3D9E A;  1BUC A;  4OO2 A;  4M9A A;  4RM7 A;  3MXL A;  4G5E A;  1FS9 A;  3AFE A;  3P4T A;  3LGQ A;  2RF7 A;  4HR3 A;  3GQT A;  3BNG A;  3HWC A;  2DVL A;  1IVH A;  4KTO A;  5K3I A;  3D9D A;  4Q5C A;  2Z1Q A;  1U8V A;  4L38 A;  3BNH A;  3EOM A;  3MMO A;  3MDE A;  2C12 A;  1UDY A;  2YYG A;  4ZXV A;  3RKH A;  3UU9 A;  2OR0 A;  5K3G A;  1EGD A;  1OAH A;  3MPI A;  2JBR A;  2FON A;  3D1I A;  2A1T A;  2JIF A;  2C0U A;  2R0M A;  3X0X A;  3X0Y A;  4ZYJ A;  2ZO5 A;  3B96 A;  2VIG A;  3FCJ A;  3R7K A;  1FS7 A;  3SF6 A;  1WS9 A;  2CX9 A;  1GU6 A;  2PG0 A;  4X28 C;  3OWA A;  1QDB A;  4WJY A;  2RFQ A;  5K3J A;  3TOR A;  3F29 A;  3MKH A;  4P13 A;  2DDH A;  1W07 A;  3MDD A;  4W9U A;  3OWM A;  2IX5 A;  3TTB A;  2JBT A;  3SXQ A;  4NXL A;  4XVX A;  2WBI A;  3D9G A;  1SIQ A;  2ZAF A;  4JEK A;  3II9 A;  4Q1O A;  3SWO A;  3S7W A;  4IV6 A;  2J7A A;  1R2J A;  1T9G A;  2D29 A;  4KCF A;  3AFF A;  4O5M A;  3L1T A;  4Q0T A;  2EBA A;  3GNC A;  2YYI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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