1EGDA

Structure of t255e, e376g mutant of human medium chain acyl-coa dehydrogenase
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
387
structure length
387
Chain Sequence
LGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKERPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYGGTSQIQRLIVAREHIDKYKN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Electron transfer
molecule keywords MEDIUM CHAIN ACYL-COA DEHYDROGENASE
publication title Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
pubmed doi rcsb
source organism Homo sapiens
total genus 148
structure length 387
sequence length 387
chains with identical sequence B, C, D
ec nomenclature ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date 1996-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1egdA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1egdA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1egdA02
4Q17A 4ZXVA 2PG0A 3D6BA 3B96A 2DDHA 4P13A 3BNFA 2FONA 2C0UA 2WBIA 3RKHA 5K3HA 4JEKA 3UBRA 1FS9A 1IVHA 4KCFA 2JBSA 1EGEA 1GU6A 3D9EA 1U8VA 3X0XA 4U83A 2E81A 2RFQA 4O5MA 3GM6A 3GNCA 3MMOA 1FS8A 2OR0A 2YYGA 4WJYA 3BNHA 4L38A 2A1TA 1EGCA 3OWAA 2YYKA 4Q4UA 4OO2A 1JQIA 4W9UA 4L3YA 3GQTA 1EGDA 3MPJA 2ZO5A 3P4TA 2RF7A 3D9DA 1RX0A 2REHA 4IV6A 3MKHA 2RDZA 3L1TA 2J7AA 3TTBA 2JIFA 3NF4A 4X28C 3MPIA 3SXQA 2VR0A 4IRNA 1QDBA 5K3GA 3OWMA 4Q1OA 4L1FA 4X28A 2D29A 3D9FA 3AFFA 4HR3A 4N5FA 2YYIA 3BNGA 4L3ZA 4XVXA 3D9GA 3X0YA 2JBRA 3M9VA 3FCJA 3MXLA 3LGQA 2C12A 3AFEA 4G5EA 1IS2A 2E80A 1SIQA 2OT4A 2DVLA 3HWCA 3R7KA 5K3IA 3EONA 2VIGA 1OAHA 3MDDA 1R2JA 3TORA 2YYJA 3FO3A 2ZAFA 3II9A 3SF6A 2R0NA 3SWOA 4ZYJA 3F29A 2EBAA 4M9AA 1WS9A 4RM7A 3BNJA 2YYMA 2CX9A 4Q5BA 2UXWA 1BUCA 2Z1QA 3EOMA 4Q5CA 3S7WA 1UDYA 2R0MA 3OIBA 4KTOA 3UU9A 3SCEA 4Q0TA 4DOYA 2JBTA 4NXLA 2IX5A 3PFDA 1UKWA 5K3JA 2YYLA 2IX6A 3D1IA 3MDEA 4L3XA 1SIRA 1W07A 1T9GA 1FS7A 3LG1A
chains in the Genus database with same CATH superfamily
4Q17A 5J71A 2Q8IA 4ZXVA 4FF1A 2PG0A 1PI1A 2Q8GA 3D6BA 3B96A 2QR4A 2DDHA 5M4NA 4P13A 3BNFA 2FONA 2C0UA 2WBIA 3RKHA 4JIOA 3Q24A 5K3HA 2OEXA 4JEKA 4F0XA 3UBRA 4AKGA 2GBBA 4MP2A 1FS9A 1IVHA 4FZ4A 4KCFA 2JBSA 1GJVA 1EGEA 1K93A 1GU6A 3D9EA 1U8VA 2CJ7A 2E0AA 4AKIA 1XFVA 5M4PA 3X0XA 2CJ4A 4U83A 1Y8NA 2ZDYA 3CE2A 4FF3A 2E81A 3Q22A 4H81A 2BU5A 3C3LA 2RFQA 4O5MA 3GM6A 3GNCA 3X29A 1SC5A 1K8TA 3MMOA 1FS8A 1XFUA 2OR0A 2ZKJA 2YYGA 2R03A 2BU2A 4WJYA 3VADA 3VKHA 4E00A 3BNHA 2XS1A 4L38A 4DZYA 2A1TA 1EGCA 3OWAA 1Y8PA 2YYKA 5J6AA 2EBHX 4Q4UA 4OO2A 1JQIA 2HJNA 4W9UA 3CRKA 3GQTA 4KS9A 1EGDA 4L3YA 3MPJA 2ZO5A 4V26A 3P4TA 2PO4A 4FF4A 2RF7A 3TZ0A 2YGWA 2OEVA 4H7QA 3D9DA 4G97A 1RX0A 2REHA 4IV6A 4J1VA 2BTZA 2VF1A 3MKHA 2FP1A 2R02A 2RDZA 5GJVE 3L1TA 2J7AA 4LQSB 1XG2B 4HKSA 2JIFA 1RP3A 3NF4A 3TTBA 5B5WA 4X28C 3MPIA 3SXQA 2VR0A 4IRNA 4FF2A 1S26A 1QDBA 1R3BA 5K3GA 3OWMA 4Q1OA 1X8ZA 4L1FA 4X28A 2D29A 3D9FA 2BU8A 5M4KA 3AFFA 4HR3A 4N5FA 2YYIA 3BNGA 4L3ZA 1RJ4A 2ZDXA 1JM6A 1K90A 2R05A 4XVXA 3VKGA 5EZ3A 2BU7A 3D9GA 4AKHA 3X0YA 2XS8A 4P79A 5M4MA 2JBRA 3M9VA 4V25A 4MPNA 3FCJA 5BRMA 3N0RA 3MXLA 3LGQA 2C12A 3AFEA 4G5EA 1IS2A 2E80A 3C2PA 1SIQA 2CJ8A 4H85A 1PK0A 1XFXA 2F6LA 2DVLA 2LFWA 2OT4A 4AI6A 3HWCA 3R7KA 2Q8FA 4LQQB 5K3IA 3EONA 2AZEA 2VIGA 1OAHA 1X91A 1XFYA 2XQRB 3MDDA 1R2JA 3TORA 2AO2A 2YYJA 3FO3A 2ZAFA 3C46A 3II9A 1GKZA 4MPEA 3CRLA 3SF6A 4QICA 4E02A 3U33A 2R0NA 2Q8HA 3SWOA 2PNRA 3TZ4A 1Y8OA 4ZYJA 1LVCA 2CJ6A 3F29A 5BRKA 2EBAA 4MP7A 4M9AA 1XFWA 4MPCA 2FP2A 1SK6A 1WS9A 4JIZA 4RM7A 2BU6A 3BNJA 1XFZA 2YYMA 1X90A 2CX9A 5B6BA 3Q0AA 4Q5BA 3D2RA 4E01A 1RJ1A 2UXWA 1BUCA 2Z1QA 3EOMA 4Q5CA 5GJWE 2OJQA 3S7WA 1UDYA 2EBFX 2R0MA 3OIBA 4KSFA 3DJLA 4KTOA 3UU9A 3SCEA 4Q0TA 4DOYA 2JBTA 4NXLA 4HKRA 3TZ5A 1Y0VA 2IX5A 3PFDA 1UKWA 5K3JA 2YYLA 1GKXA 2IX6A 3D1IA 2EC5A 5B5VA 3MDEA 3TZ2A 4KSAA 1SIRA 4L3XA 3Q23A 2CJ5A 1W07A 1T9GA 1FS7A 3KMLA 3LG1A
chains in the Genus database with same CATH topology
4Q17A 4ZXVA 2PG0A 3D6BA 3B96A 2DDHA 4P13A 3BNFA 2FONA 2C0UA 2WBIA 3RKHA 5K3HA 4JEKA 3UBRA 1FS9A 1IVHA 4KCFA 2JBSA 1EGEA 1GU6A 3D9EA 1U8VA 3X0XA 4U83A 2E81A 2RFQA 4O5MA 3GM6A 3GNCA 3MMOA 1FS8A 2OR0A 2YYGA 4WJYA 3BNHA 4L38A 2A1TA 1EGCA 3OWAA 2YYKA 4Q4UA 4OO2A 1JQIA 4W9UA 4L3YA 3GQTA 1EGDA 3MPJA 2ZO5A 3P4TA 2RF7A 3D9DA 1RX0A 2REHA 4IV6A 3MKHA 2RDZA 3L1TA 2J7AA 3TTBA 2JIFA 3NF4A 4X28C 3MPIA 3SXQA 2VR0A 4IRNA 1QDBA 5K3GA 3OWMA 4Q1OA 4L1FA 4X28A 2D29A 3D9FA 3AFFA 4HR3A 4N5FA 2YYIA 3BNGA 4L3ZA 4XVXA 3D9GA 3X0YA 2JBRA 3M9VA 3FCJA 3MXLA 3LGQA 2C12A 3AFEA 4G5EA 1IS2A 2E80A 1SIQA 2OT4A 2DVLA 3HWCA 3R7KA 5K3IA 3EONA 2VIGA 1OAHA 3MDDA 1R2JA 3TORA 2YYJA 3FO3A 2ZAFA 3II9A 3SF6A 2R0NA 3SWOA 4ZYJA 3F29A 2EBAA 4M9AA 1WS9A 4RM7A 3BNJA 2YYMA 2CX9A 4Q5BA 2UXWA 1BUCA 2Z1QA 3EOMA 4Q5CA 3S7WA 1UDYA 2R0MA 3OIBA 4KTOA 3UU9A 3SCEA 4Q0TA 4DOYA 2JBTA 4NXLA 2IX5A 3PFDA 1UKWA 5K3JA 2YYLA 2IX6A 3D1IA 3MDEA 4L3XA 1SIRA 1W07A 1T9GA 1FS7A 3LG1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q17 A;  4ZXV A;  2PG0 A;  3D6B A;  3B96 A;  2DDH A;  4P13 A;  3BNF A;  2FON A;  2C0U A;  2WBI A;  3RKH A;  5K3H A;  4JEK A;  3UBR A;  1FS9 A;  1IVH A;  4KCF A;  2JBS A;  1EGE A;  1GU6 A;  3D9E A;  1U8V A;  3X0X A;  4U83 A;  2E81 A;  2RFQ A;  4O5M A;  3GM6 A;  3GNC A;  3MMO A;  1FS8 A;  2OR0 A;  2YYG A;  4WJY A;  3BNH A;  4L38 A;  2A1T A;  1EGC A;  3OWA A;  2YYK A;  4Q4U A;  4OO2 A;  1JQI A;  4W9U A;  4L3Y A;  3GQT A;  1EGD A;  3MPJ A;  2ZO5 A;  3P4T A;  2RF7 A;  3D9D A;  1RX0 A;  2REH A;  4IV6 A;  3MKH A;  2RDZ A;  3L1T A;  2J7A A;  3TTB A;  2JIF A;  3NF4 A;  4X28 C;  3MPI A;  3SXQ A;  2VR0 A;  4IRN A;  1QDB A;  5K3G A;  3OWM A;  4Q1O A;  4L1F A;  4X28 A;  2D29 A;  3D9F A;  3AFF A;  4HR3 A;  4N5F A;  2YYI A;  3BNG A;  4L3Z A;  4XVX A;  3D9G A;  3X0Y A;  2JBR A;  3M9V A;  3FCJ A;  3MXL A;  3LGQ A;  2C12 A;  3AFE A;  4G5E A;  1IS2 A;  2E80 A;  1SIQ A;  2OT4 A;  2DVL A;  3HWC A;  3R7K A;  5K3I A;  3EON A;  2VIG A;  1OAH A;  3MDD A;  1R2J A;  3TOR A;  2YYJ A;  3FO3 A;  2ZAF A;  3II9 A;  3SF6 A;  2R0N A;  3SWO A;  4ZYJ A;  3F29 A;  2EBA A;  4M9A A;  1WS9 A;  4RM7 A;  3BNJ A;  2YYM A;  2CX9 A;  4Q5B A;  2UXW A;  1BUC A;  2Z1Q A;  3EOM A;  4Q5C A;  3S7W A;  1UDY A;  2R0M A;  3OIB A;  4KTO A;  3UU9 A;  3SCE A;  4Q0T A;  4DOY A;  2JBT A;  4NXL A;  2IX5 A;  3PFD A;  1UKW A;  5K3J A;  2YYL A;  2IX6 A;  3D1I A;  3MDE A;  4L3X A;  1SIR A;  1W07 A;  1T9G A;  1FS7 A;  3LG1 A; 
#chains in the Genus database with same CATH topology
 4Q17 A;  5J71 A;  2Q8I A;  4ZXV A;  4FF1 A;  2PG0 A;  1PI1 A;  2Q8G A;  3D6B A;  3B96 A;  2QR4 A;  2DDH A;  5M4N A;  4P13 A;  3BNF A;  2FON A;  2C0U A;  2WBI A;  3RKH A;  4JIO A;  3Q24 A;  5K3H A;  2OEX A;  4JEK A;  4F0X A;  3UBR A;  4AKG A;  2GBB A;  4MP2 A;  1FS9 A;  1IVH A;  4FZ4 A;  4KCF A;  2JBS A;  1GJV A;  1EGE A;  1K93 A;  1GU6 A;  3D9E A;  1U8V A;  2CJ7 A;  2E0A A;  4AKI A;  1XFV A;  5M4P A;  3X0X A;  2CJ4 A;  4U83 A;  1Y8N A;  2ZDY A;  3CE2 A;  4FF3 A;  2E81 A;  3Q22 A;  4H81 A;  2BU5 A;  3C3L A;  2RFQ A;  4O5M A;  3GM6 A;  3GNC A;  3X29 A;  1SC5 A;  1K8T A;  3MMO A;  1FS8 A;  1XFU A;  2OR0 A;  2ZKJ A;  2YYG A;  2R03 A;  2BU2 A;  4WJY A;  3VAD A;  3VKH A;  4E00 A;  3BNH A;  2XS1 A;  4L38 A;  4DZY A;  2A1T A;  1EGC A;  3OWA A;  1Y8P A;  2YYK A;  5J6A A;  2EBH X;  4Q4U A;  4OO2 A;  1JQI A;  2HJN A;  4W9U A;  3CRK A;  3GQT A;  4KS9 A;  1EGD A;  4L3Y A;  3MPJ A;  2ZO5 A;  4V26 A;  3P4T A;  2PO4 A;  4FF4 A;  2RF7 A;  3TZ0 A;  2YGW A;  2OEV A;  4H7Q A;  3D9D A;  4G97 A;  1RX0 A;  2REH A;  4IV6 A;  4J1V A;  2BTZ A;  2VF1 A;  3MKH A;  2FP1 A;  2R02 A;  2RDZ A;  5GJV E;  3L1T A;  2J7A A;  4LQS B;  1XG2 B;  4HKS A;  2JIF A;  1RP3 A;  3NF4 A;  3TTB A;  5B5W A;  4X28 C;  3MPI A;  3SXQ A;  2VR0 A;  4IRN A;  4FF2 A;  1S26 A;  1QDB A;  1R3B A;  5K3G A;  3OWM A;  4Q1O A;  1X8Z A;  4L1F A;  4X28 A;  2D29 A;  3D9F A;  2BU8 A;  5M4K A;  3AFF A;  4HR3 A;  4N5F A;  2YYI A;  3BNG A;  4L3Z A;  1RJ4 A;  2ZDX A;  1JM6 A;  1K90 A;  2R05 A;  4XVX A;  3VKG A;  5EZ3 A;  2BU7 A;  3D9G A;  4AKH A;  3X0Y A;  2XS8 A;  4P79 A;  5M4M A;  2JBR A;  3M9V A;  4V25 A;  4MPN A;  3FCJ A;  5BRM A;  3N0R A;  3MXL A;  3LGQ A;  2C12 A;  3AFE A;  4G5E A;  1IS2 A;  2E80 A;  3C2P A;  1SIQ A;  2CJ8 A;  4H85 A;  1PK0 A;  1XFX A;  2F6L A;  2DVL A;  2LFW A;  2OT4 A;  4AI6 A;  3HWC A;  3R7K A;  2Q8F A;  4LQQ B;  5K3I A;  3EON A;  2AZE A;  2VIG A;  1OAH A;  1X91 A;  1XFY A;  2XQR B;  3MDD A;  1R2J A;  3TOR A;  2AO2 A;  2YYJ A;  3FO3 A;  2ZAF A;  3C46 A;  3II9 A;  1GKZ A;  4MPE A;  3CRL A;  3SF6 A;  4QIC A;  4E02 A;  3U33 A;  2R0N A;  2Q8H A;  3SWO A;  2PNR A;  3TZ4 A;  1Y8O A;  4ZYJ A;  1LVC A;  2CJ6 A;  3F29 A;  5BRK A;  2EBA A;  4MP7 A;  4M9A A;  1XFW A;  4MPC A;  2FP2 A;  1SK6 A;  1WS9 A;  4JIZ A;  4RM7 A;  2BU6 A;  3BNJ A;  1XFZ A;  2YYM A;  1X90 A;  2CX9 A;  5B6B A;  3Q0A A;  4Q5B A;  3D2R A;  4E01 A;  1RJ1 A;  2UXW A;  1BUC A;  2Z1Q A;  3EOM A;  4Q5C A;  5GJW E;  2OJQ A;  3S7W A;  1UDY A;  2EBF X;  2R0M A;  3OIB A;  4KSF A;  3DJL A;  4KTO A;  3UU9 A;  3SCE A;  4Q0T A;  4DOY A;  2JBT A;  4NXL A;  4HKR A;  3TZ5 A;  1Y0V A;  2IX5 A;  3PFD A;  1UKW A;  5K3J A;  2YYL A;  1GKX A;  2IX6 A;  3D1I A;  2EC5 A;  5B5V A;  3MDE A;  3TZ2 A;  4KSA A;  1SIR A;  4L3X A;  3Q23 A;  2CJ5 A;  1W07 A;  1T9G A;  1FS7 A;  3KML A;  3LG1 A; 
#chains in the Genus database with same CATH homology
 4Q17 A;  4ZXV A;  2PG0 A;  3D6B A;  3B96 A;  2DDH A;  4P13 A;  3BNF A;  2FON A;  2C0U A;  2WBI A;  3RKH A;  5K3H A;  4JEK A;  3UBR A;  1FS9 A;  1IVH A;  4KCF A;  2JBS A;  1EGE A;  1GU6 A;  3D9E A;  1U8V A;  3X0X A;  4U83 A;  2E81 A;  2RFQ A;  4O5M A;  3GM6 A;  3GNC A;  3MMO A;  1FS8 A;  2OR0 A;  2YYG A;  4WJY A;  3BNH A;  4L38 A;  2A1T A;  1EGC A;  3OWA A;  2YYK A;  4Q4U A;  4OO2 A;  1JQI A;  4W9U A;  4L3Y A;  3GQT A;  1EGD A;  3MPJ A;  2ZO5 A;  3P4T A;  2RF7 A;  3D9D A;  1RX0 A;  2REH A;  4IV6 A;  3MKH A;  2RDZ A;  3L1T A;  2J7A A;  3TTB A;  2JIF A;  3NF4 A;  4X28 C;  3MPI A;  3SXQ A;  2VR0 A;  4IRN A;  1QDB A;  5K3G A;  3OWM A;  4Q1O A;  4L1F A;  4X28 A;  2D29 A;  3D9F A;  3AFF A;  4HR3 A;  4N5F A;  2YYI A;  3BNG A;  4L3Z A;  4XVX A;  3D9G A;  3X0Y A;  2JBR A;  3M9V A;  3FCJ A;  3MXL A;  3LGQ A;  2C12 A;  3AFE A;  4G5E A;  1IS2 A;  2E80 A;  1SIQ A;  2OT4 A;  2DVL A;  3HWC A;  3R7K A;  5K3I A;  3EON A;  2VIG A;  1OAH A;  3MDD A;  1R2J A;  3TOR A;  2YYJ A;  3FO3 A;  2ZAF A;  3II9 A;  3SF6 A;  2R0N A;  3SWO A;  4ZYJ A;  3F29 A;  2EBA A;  4M9A A;  1WS9 A;  4RM7 A;  3BNJ A;  2YYM A;  2CX9 A;  4Q5B A;  2UXW A;  1BUC A;  2Z1Q A;  3EOM A;  4Q5C A;  3S7W A;  1UDY A;  2R0M A;  3OIB A;  4KTO A;  3UU9 A;  3SCE A;  4Q0T A;  4DOY A;  2JBT A;  4NXL A;  2IX5 A;  3PFD A;  1UKW A;  5K3J A;  2YYL A;  2IX6 A;  3D1I A;  3MDE A;  4L3X A;  1SIR A;  1W07 A;  1T9G A;  1FS7 A;  3LG1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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