4X28A

Crystal structure of the chse4-chse5 complex from mycobacterium tuberculosis
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
399
structure length
386
Chain Sequence
MRISYTPQQEELRRELRSYFATLMTPERREALSSVNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDVRVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLARVHAKAEVLKLINWELASSQGPSPADASAAKVFGTELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRAN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Acyl-CoA dehydrogenase
publication title Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha 2 beta 2 Acyl-CoA Dehydrogenase Initiates beta-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain atcc 25618 / h37rv)
molecule tags Oxidoreductase
total genus 129
structure length 386
sequence length 399
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-11-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 4x28A01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 4x28A03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 4x28A02
2IX6A 1OAHA 2JBRA 1U8VA 2YYIA 1IVHA 3AFFA 3GQTA 2A1TA 3UBRA 1W07A 3D6BA 2VIGA 4G5EA 2OR0A 2R0NA 3M9VA 4P13A 1UDYA 2REHA 4Q1OA 4Q5BA 1FS7A 4Q4UA 3MDDA 1EGCA 2VR0A 3GNCA 2R0MA 3SF6A 2WBIA 1JQIA 3FCJA 4JEKA 2C0UA 4WJYA 2JIFA 4IV6A 3TORA 1GU6A 3D9DA 2UXWA 2YYKA 2EBAA 3HWCA 3LG1A 3MXLA 3GM6A 2FONA 3S7WA 3UU9A 2E80A 2DVLA 1EGEA 3AFEA 3OWMA 3TTBA 5K3IA 2OT4A 3SXQA 2C12A 5K3JA 2ZAFA 4L3XA 2YYMA 4N5FA 3LGQA 3BNFA 3NF4A 4IRNA 3II9A 1T9GA 4L3ZA 4RM7A 1IS2A 1UKWA 4L3YA 4DOYA 4O5MA 4KTOA 3OIBA 2RFQA 3X0XA 4L38A 1RX0A 3P4TA 3MPJA 2YYJA 3RKHA 3D9EA 4U83A 3B96A 3SCEA 1SIQA 2JBTA 1BUCA 4Q17A 4ZXVA 2J7AA 3BNGA 3F29A 3EONA 3EOMA 3MDEA 3MPIA 2RF7A 4ZYJA 2JBSA 3D9GA 3FO3A 1SIRA 3R7KA 2PG0A 3MMOA 1EGDA 2IX5A 2E81A 2D29A 2CX9A 3D1IA 4Q0TA 3SWOA 4X28C 4OO2A 1FS8A 3D9FA 3MKHA 3BNJA 1R2JA 2ZO5A 3OWAA 1QDBA 3BNHA 4KCFA 2YYLA 5K3HA 3X0YA 4XVXA 1WS9A 5K3GA 3PFDA 4HR3A 2YYGA 4X28A 4M9AA 2Z1QA 3L1TA 1FS9A 2DDHA 2RDZA 4Q5CA 4W9UA 4L1FA 4NXLA
chains in the Genus database with same CATH superfamily
2XS1A 1PI1A 5J71A 2F6LA 2IX6A 2BU5A 1OAHA 2JBRA 4LQQB 2Q8IA 1U8VA 4FF1A 2YYIA 1SC5A 1IVHA 1GJVA 3AFFA 3GQTA 1XFXA 2A1TA 2CJ8A 2CJ7A 2R02A 3UBRA 1W07A 3D6BA 5M4PA 1RJ1A 4JIZA 3VKGA 2VIGA 5B5VA 2Q8HA 4G5EA 4KSFA 2OR0A 2FP2A 1SK6A 2R0NA 1X90A 3M9VA 4P13A 1UDYA 2REHA 4MP2A 4Q1OA 1K8TA 1XFYA 1Y8OA 2PNRA 4Q5BA 1FS7A 4Q4UA 3MDDA 2BU7A 1EGCA 4QICA 2VR0A 3GNCA 2R0MA 4E01A 3SF6A 2WBIA 1JQIA 1XG2B 2BU8A 3Q22A 3FCJA 4AKGA 4JEKA 2C0UA 1GKZA 4V25A 4WJYA 5B6BA 2JIFA 4IV6A 4F0XA 4MPEA 2CJ4A 3TORA 1GU6A 3TZ2A 2ZKJA 4LQSB 4KS9A 3TZ5A 4AI6A 3Q24A 3D9DA 2UXWA 2YYKA 2EBAA 3HWCA 3LG1A 4AKHA 3MXLA 3GM6A 3KMLA 2FONA 4H81A 3S7WA 3UU9A 1XFUA 2E80A 2DVLA 2PO4A 1EGEA 3AFEA 1X91A 3CE2A 3D2RA 3OWMA 5BRMA 4E00A 3TTBA 2GBBA 5M4MA 2FP1A 5K3IA 2OT4A 3SXQA 3C46A 2AZEA 2C12A 5K3JA 2ZAFA 4L3XA 3N0RA 1Y8PA 2EBHX 1RP3A 2YYMA 4N5FA 3LGQA 4FF4A 3BNFA 3NF4A 4IRNA 3II9A 1PK0A 1X8ZA 4G97A 4MP7A 1T9GA 2YGWA 5B5WA 4H85A 4L3ZA 1R3BA 4RM7A 3TZ4A 3VADA 1IS2A 1UKWA 1Y8NA 4L3YA 4V26A 4MPCA 4DOYA 2XS8A 2Q8GA 5EZ3A 4O5MA 4KTOA 3OIBA 2EC5A 2AO2A 4FF2A 2RFQA 3Q0AA 4JIOA 3X0XA 1LVCA 4L38A 2BU6A 1RX0A 3P4TA 3MPJA 3VKHA 2YYJA 3RKHA 3D9EA 5M4KA 4HKRA 4U83A 1K90A 2LFWA 3B96A 5BRKA 2OEVA 2CJ6A 1Y0VA 3SCEA 1SIQA 2JBTA 2E0AA 2QR4A 4J1VA 4P79A 1BUCA 3C3LA 4Q17A 4H7QA 4ZXVA 2OEXA 2BTZA 2J7AA 3Q23A 3TZ0A 4KSAA 3BNGA 2BU2A 2R05A 3F29A 4AKIA 3EONA 3EOMA 3MDEA 3MPIA 1XFVA 1RJ4A 4ZYJA 2RF7A 2JBSA 3D9GA 4FZ4A 4E02A 2CJ5A 3FO3A 3X29A 5M4NA 4HKSA 1SIRA 3R7KA 2Q8FA 2PG0A 2ZDXA 1S26A 2VF1A 3MMOA 1EGDA 4MPNA 4FF3A 2IX5A 2E81A 2D29A 2EBFX 2CX9A 3D1IA 4Q0TA 3SWOA 4X28C 1GKXA 3C2PA 4OO2A 1FS8A 3D9FA 3MKHA 3BNJA 1R2JA 2ZO5A 3OWAA 1QDBA 3BNHA 4KCFA 4DZYA 5J6AA 2YYLA 5K3HA 1JM6A 3X0YA 4XVXA 1WS9A 3U33A 5K3GA 3PFDA 4HR3A 2YYGA 4X28A 4M9AA 3CRKA 5GJVE 1XFWA 2Z1QA 3DJLA 3L1TA 1FS9A 2DDHA 5GJWE 1K93A 2OJQA 2RDZA 2XQRB 2HJNA 4Q5CA 4W9UA 2R03A 3CRLA 2ZDYA 1XFZA 4L1FA 4NXLA
chains in the Genus database with same CATH topology
2IX6A 1OAHA 2JBRA 1U8VA 2YYIA 1IVHA 3AFFA 3GQTA 2A1TA 3UBRA 1W07A 3D6BA 2VIGA 4G5EA 2OR0A 2R0NA 3M9VA 4P13A 1UDYA 2REHA 4Q1OA 4Q5BA 1FS7A 4Q4UA 3MDDA 1EGCA 2VR0A 3GNCA 2R0MA 3SF6A 2WBIA 1JQIA 3FCJA 4JEKA 2C0UA 4WJYA 2JIFA 4IV6A 3TORA 1GU6A 3D9DA 2UXWA 2YYKA 2EBAA 3HWCA 3LG1A 3MXLA 3GM6A 2FONA 3S7WA 3UU9A 2E80A 2DVLA 1EGEA 3AFEA 3OWMA 3TTBA 5K3IA 2OT4A 3SXQA 2C12A 5K3JA 2ZAFA 4L3XA 2YYMA 4N5FA 3LGQA 3BNFA 3NF4A 4IRNA 3II9A 1T9GA 4L3ZA 4RM7A 1IS2A 1UKWA 4L3YA 4DOYA 4O5MA 4KTOA 3OIBA 2RFQA 3X0XA 4L38A 1RX0A 3P4TA 3MPJA 2YYJA 3RKHA 3D9EA 4U83A 3B96A 3SCEA 1SIQA 2JBTA 1BUCA 4Q17A 4ZXVA 2J7AA 3BNGA 3F29A 3EONA 3EOMA 3MDEA 3MPIA 2RF7A 4ZYJA 2JBSA 3D9GA 3FO3A 1SIRA 3R7KA 2PG0A 3MMOA 1EGDA 2IX5A 2E81A 2D29A 2CX9A 3D1IA 4Q0TA 3SWOA 4X28C 4OO2A 1FS8A 3D9FA 3MKHA 3BNJA 1R2JA 2ZO5A 3OWAA 1QDBA 3BNHA 4KCFA 2YYLA 5K3HA 3X0YA 4XVXA 1WS9A 5K3GA 3PFDA 4HR3A 2YYGA 4X28A 4M9AA 2Z1QA 3L1TA 1FS9A 2DDHA 2RDZA 4Q5CA 4W9UA 4L1FA 4NXLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IX6 A;  1OAH A;  2JBR A;  1U8V A;  2YYI A;  1IVH A;  3AFF A;  3GQT A;  2A1T A;  3UBR A;  1W07 A;  3D6B A;  2VIG A;  4G5E A;  2OR0 A;  2R0N A;  3M9V A;  4P13 A;  1UDY A;  2REH A;  4Q1O A;  4Q5B A;  1FS7 A;  4Q4U A;  3MDD A;  1EGC A;  2VR0 A;  3GNC A;  2R0M A;  3SF6 A;  2WBI A;  1JQI A;  3FCJ A;  4JEK A;  2C0U A;  4WJY A;  2JIF A;  4IV6 A;  3TOR A;  1GU6 A;  3D9D A;  2UXW A;  2YYK A;  2EBA A;  3HWC A;  3LG1 A;  3MXL A;  3GM6 A;  2FON A;  3S7W A;  3UU9 A;  2E80 A;  2DVL A;  1EGE A;  3AFE A;  3OWM A;  3TTB A;  5K3I A;  2OT4 A;  3SXQ A;  2C12 A;  5K3J A;  2ZAF A;  4L3X A;  2YYM A;  4N5F A;  3LGQ A;  3BNF A;  3NF4 A;  4IRN A;  3II9 A;  1T9G A;  4L3Z A;  4RM7 A;  1IS2 A;  1UKW A;  4L3Y A;  4DOY A;  4O5M A;  4KTO A;  3OIB A;  2RFQ A;  3X0X A;  4L38 A;  1RX0 A;  3P4T A;  3MPJ A;  2YYJ A;  3RKH A;  3D9E A;  4U83 A;  3B96 A;  3SCE A;  1SIQ A;  2JBT A;  1BUC A;  4Q17 A;  4ZXV A;  2J7A A;  3BNG A;  3F29 A;  3EON A;  3EOM A;  3MDE A;  3MPI A;  2RF7 A;  4ZYJ A;  2JBS A;  3D9G A;  3FO3 A;  1SIR A;  3R7K A;  2PG0 A;  3MMO A;  1EGD A;  2IX5 A;  2E81 A;  2D29 A;  2CX9 A;  3D1I A;  4Q0T A;  3SWO A;  4X28 C;  4OO2 A;  1FS8 A;  3D9F A;  3MKH A;  3BNJ A;  1R2J A;  2ZO5 A;  3OWA A;  1QDB A;  3BNH A;  4KCF A;  2YYL A;  5K3H A;  3X0Y A;  4XVX A;  1WS9 A;  5K3G A;  3PFD A;  4HR3 A;  2YYG A;  4X28 A;  4M9A A;  2Z1Q A;  3L1T A;  1FS9 A;  2DDH A;  2RDZ A;  4Q5C A;  4W9U A;  4L1F A;  4NXL A; 
#chains in the Genus database with same CATH topology
 2XS1 A;  1PI1 A;  5J71 A;  2F6L A;  2IX6 A;  2BU5 A;  1OAH A;  2JBR A;  4LQQ B;  2Q8I A;  1U8V A;  4FF1 A;  2YYI A;  1SC5 A;  1IVH A;  1GJV A;  3AFF A;  3GQT A;  1XFX A;  2A1T A;  2CJ8 A;  2CJ7 A;  2R02 A;  3UBR A;  1W07 A;  3D6B A;  5M4P A;  1RJ1 A;  4JIZ A;  3VKG A;  2VIG A;  5B5V A;  2Q8H A;  4G5E A;  4KSF A;  2OR0 A;  2FP2 A;  1SK6 A;  2R0N A;  1X90 A;  3M9V A;  4P13 A;  1UDY A;  2REH A;  4MP2 A;  4Q1O A;  1K8T A;  1XFY A;  1Y8O A;  2PNR A;  4Q5B A;  1FS7 A;  4Q4U A;  3MDD A;  2BU7 A;  1EGC A;  4QIC A;  2VR0 A;  3GNC A;  2R0M A;  4E01 A;  3SF6 A;  2WBI A;  1JQI A;  1XG2 B;  2BU8 A;  3Q22 A;  3FCJ A;  4AKG A;  4JEK A;  2C0U A;  1GKZ A;  4V25 A;  4WJY A;  5B6B A;  2JIF A;  4IV6 A;  4F0X A;  4MPE A;  2CJ4 A;  3TOR A;  1GU6 A;  3TZ2 A;  2ZKJ A;  4LQS B;  4KS9 A;  3TZ5 A;  4AI6 A;  3Q24 A;  3D9D A;  2UXW A;  2YYK A;  2EBA A;  3HWC A;  3LG1 A;  4AKH A;  3MXL A;  3GM6 A;  3KML A;  2FON A;  4H81 A;  3S7W A;  3UU9 A;  1XFU A;  2E80 A;  2DVL A;  2PO4 A;  1EGE A;  3AFE A;  1X91 A;  3CE2 A;  3D2R A;  3OWM A;  5BRM A;  4E00 A;  3TTB A;  2GBB A;  5M4M A;  2FP1 A;  5K3I A;  2OT4 A;  3SXQ A;  3C46 A;  2AZE A;  2C12 A;  5K3J A;  2ZAF A;  4L3X A;  3N0R A;  1Y8P A;  2EBH X;  1RP3 A;  2YYM A;  4N5F A;  3LGQ A;  4FF4 A;  3BNF A;  3NF4 A;  4IRN A;  3II9 A;  1PK0 A;  1X8Z A;  4G97 A;  4MP7 A;  1T9G A;  2YGW A;  5B5W A;  4H85 A;  4L3Z A;  1R3B A;  4RM7 A;  3TZ4 A;  3VAD A;  1IS2 A;  1UKW A;  1Y8N A;  4L3Y A;  4V26 A;  4MPC A;  4DOY A;  2XS8 A;  2Q8G A;  5EZ3 A;  4O5M A;  4KTO A;  3OIB A;  2EC5 A;  2AO2 A;  4FF2 A;  2RFQ A;  3Q0A A;  4JIO A;  3X0X A;  1LVC A;  4L38 A;  2BU6 A;  1RX0 A;  3P4T A;  3MPJ A;  3VKH A;  2YYJ A;  3RKH A;  3D9E A;  5M4K A;  4HKR A;  4U83 A;  1K90 A;  2LFW A;  3B96 A;  5BRK A;  2OEV A;  2CJ6 A;  1Y0V A;  3SCE A;  1SIQ A;  2JBT A;  2E0A A;  2QR4 A;  4J1V A;  4P79 A;  1BUC A;  3C3L A;  4Q17 A;  4H7Q A;  4ZXV A;  2OEX A;  2BTZ A;  2J7A A;  3Q23 A;  3TZ0 A;  4KSA A;  3BNG A;  2BU2 A;  2R05 A;  3F29 A;  4AKI A;  3EON A;  3EOM A;  3MDE A;  3MPI A;  1XFV A;  1RJ4 A;  4ZYJ A;  2RF7 A;  2JBS A;  3D9G A;  4FZ4 A;  4E02 A;  2CJ5 A;  3FO3 A;  3X29 A;  5M4N A;  4HKS A;  1SIR A;  3R7K A;  2Q8F A;  2PG0 A;  2ZDX A;  1S26 A;  2VF1 A;  3MMO A;  1EGD A;  4MPN A;  4FF3 A;  2IX5 A;  2E81 A;  2D29 A;  2EBF X;  2CX9 A;  3D1I A;  4Q0T A;  3SWO A;  4X28 C;  1GKX A;  3C2P A;  4OO2 A;  1FS8 A;  3D9F A;  3MKH A;  3BNJ A;  1R2J A;  2ZO5 A;  3OWA A;  1QDB A;  3BNH A;  4KCF A;  4DZY A;  5J6A A;  2YYL A;  5K3H A;  1JM6 A;  3X0Y A;  4XVX A;  1WS9 A;  3U33 A;  5K3G A;  3PFD A;  4HR3 A;  2YYG A;  4X28 A;  4M9A A;  3CRK A;  5GJV E;  1XFW A;  2Z1Q A;  3DJL A;  3L1T A;  1FS9 A;  2DDH A;  5GJW E;  1K93 A;  2OJQ A;  2RDZ A;  2XQR B;  2HJN A;  4Q5C A;  4W9U A;  2R03 A;  3CRL A;  2ZDY A;  1XFZ A;  4L1F A;  4NXL A; 
#chains in the Genus database with same CATH homology
 2IX6 A;  1OAH A;  2JBR A;  1U8V A;  2YYI A;  1IVH A;  3AFF A;  3GQT A;  2A1T A;  3UBR A;  1W07 A;  3D6B A;  2VIG A;  4G5E A;  2OR0 A;  2R0N A;  3M9V A;  4P13 A;  1UDY A;  2REH A;  4Q1O A;  4Q5B A;  1FS7 A;  4Q4U A;  3MDD A;  1EGC A;  2VR0 A;  3GNC A;  2R0M A;  3SF6 A;  2WBI A;  1JQI A;  3FCJ A;  4JEK A;  2C0U A;  4WJY A;  2JIF A;  4IV6 A;  3TOR A;  1GU6 A;  3D9D A;  2UXW A;  2YYK A;  2EBA A;  3HWC A;  3LG1 A;  3MXL A;  3GM6 A;  2FON A;  3S7W A;  3UU9 A;  2E80 A;  2DVL A;  1EGE A;  3AFE A;  3OWM A;  3TTB A;  5K3I A;  2OT4 A;  3SXQ A;  2C12 A;  5K3J A;  2ZAF A;  4L3X A;  2YYM A;  4N5F A;  3LGQ A;  3BNF A;  3NF4 A;  4IRN A;  3II9 A;  1T9G A;  4L3Z A;  4RM7 A;  1IS2 A;  1UKW A;  4L3Y A;  4DOY A;  4O5M A;  4KTO A;  3OIB A;  2RFQ A;  3X0X A;  4L38 A;  1RX0 A;  3P4T A;  3MPJ A;  2YYJ A;  3RKH A;  3D9E A;  4U83 A;  3B96 A;  3SCE A;  1SIQ A;  2JBT A;  1BUC A;  4Q17 A;  4ZXV A;  2J7A A;  3BNG A;  3F29 A;  3EON A;  3EOM A;  3MDE A;  3MPI A;  2RF7 A;  4ZYJ A;  2JBS A;  3D9G A;  3FO3 A;  1SIR A;  3R7K A;  2PG0 A;  3MMO A;  1EGD A;  2IX5 A;  2E81 A;  2D29 A;  2CX9 A;  3D1I A;  4Q0T A;  3SWO A;  4X28 C;  4OO2 A;  1FS8 A;  3D9F A;  3MKH A;  3BNJ A;  1R2J A;  2ZO5 A;  3OWA A;  1QDB A;  3BNH A;  4KCF A;  2YYL A;  5K3H A;  3X0Y A;  4XVX A;  1WS9 A;  5K3G A;  3PFD A;  4HR3 A;  2YYG A;  4X28 A;  4M9A A;  2Z1Q A;  3L1T A;  1FS9 A;  2DDH A;  2RDZ A;  4Q5C A;  4W9U A;  4L1F A;  4NXL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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