4X28A

Crystal structure of the chse4-chse5 complex from mycobacterium tuberculosis
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
399
structure length
386
Chain Sequence
MRISYTPQQEELRRELRSYFATLMTPERREALSSVNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDVRVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLARVHAKAEVLKLINWELASSQGPSPADASAAKVFGTELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Acyl-CoA dehydrogenase
publication title Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha 2 beta 2 Acyl-CoA Dehydrogenase Initiates beta-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain atcc 25618 / h37rv)
total genus 129
structure length 386
sequence length 399
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-11-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 4x28A01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 4x28A03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 4x28A02
3MPJA 2RF7A 1QDBA 3MKHA 1UKWA 3UU9A 2CX9A 1R2JA 2IX5A 1BUCA 4KTOA 1EGCA 1W07A 4NXLA 2E81A 3D9GA 2YYMA 3LG1A 1SIQA 2YYGA 4M9AA 3D1IA 4ZYJA 3OIBA 2Z1QA 3L1TA 3GM6A 3BNHA 3MDDA 1WS9A 4P13A 3FCJA 3MMOA 2JIFA 1RX0A 4IRNA 4HR3A 3HWCA 3TTBA 2DDHA 5K3JA 2ZAFA 3MDEA 3F29A 2VR0A 3PFDA 3X0XA 3D9FA 4WJYA 2YYIA 3LGQA 2JBRA 1U8VA 3R7KA 3D6BA 1GU6A 1IS2A 2IX6A 4Q1OA 1FS8A 2JBSA 2VIGA 2OT4A 3RKHA 2WBIA 4JEKA 2RFQA 3B96A 3OWAA 3SXQA 3EOMA 1SIRA 2YYJA 4Q5CA 4L3YA 3BNJA 2ZO5A 2DVLA 4L3XA 4IV6A 2J7AA 2R0MA 5K3IA 2A1TA 3OWMA 2E80A 3AFFA 3D9DA 4Q5BA 4X28A 4OO2A 2JBTA 2FONA 3D9EA 3II9A 4KCFA 3SWOA 4W9UA 4XVXA 3X0YA 3BNGA 4G5EA 5K3GA 2R0NA 4DOYA 3M9VA 2EBAA 3SCEA 2C0UA 2D29A 1UDYA 4L38A 1JQIA 3BNFA 3NF4A 4Q4UA 2YYLA 4Q17A 4RM7A 4O5MA 1EGDA 4X28C 4U83A 3EONA 3S7WA 2C12A 1FS9A 4L3ZA 4ZXVA 4Q0TA 3AFEA 3SF6A 1OAHA 3UBRA 2RDZA 2YYKA 2PG0A 3FO3A 1FS7A 4N5FA 1IVHA 2UXWA 3P4TA 4L1FA 2REHA 5K3HA 2OR0A 3GQTA 3TORA 1EGEA 3GNCA 1T9GA 3MPIA 3MXLA
chains in the Genus database with same CATH superfamily
4LQQB 5B5VA 3MPJA 2E0AA 1X90A 2RF7A 2OEVA 4AI6A 5BRMA 3KMLA 1QDBA 3N0RA 3CRLA 3MKHA 1UKWA 3UU9A 3VKHA 2CX9A 1R2JA 4MPNA 2VF1A 4J1VA 1K8TA 2IX5A 1BUCA 4KTOA 1EGCA 1W07A 4NXLA 1RJ1A 3D9GA 2E81A 1XFVA 2R03A 2YYMA 1R3BA 2EBHX 3CRKA 3LG1A 1XFUA 3VADA 2PNRA 1SIQA 4F0XA 5M4MA 2YYGA 4M9AA 3D1IA 1S26A 2Q8FA 5EZ3A 4ZYJA 3OIBA 2Z1QA 3L1TA 2BU6A 4HKRA 3DJLA 3GM6A 3BNHA 3C3LA 1XFXA 2AO2A 3MDDA 3X29A 5B5WA 3Q0AA 4JIZA 1WS9A 3TZ2A 2FP1A 4P13A 3FCJA 4MPCA 3MMOA 2JIFA 4FF1A 1RX0A 4IRNA 4HR3A 1XFWA 2ZDXA 3HWCA 3TTBA 2DDHA 5K3JA 2ZAFA 3MDEA 4G97A 3F29A 5J71A 4FF2A 1XFZA 2VR0A 3D2RA 3PFDA 3X0XA 3C2PA 3D9FA 4WJYA 4AKIA 4E01A 4MP7A 2YYIA 3LGQA 2JBRA 1U8VA 3R7KA 3D6BA 2FP2A 4QICA 4JIOA 3TZ5A 1GU6A 5BRKA 1IS2A 2QR4A 2R05A 1XG2B 2EC5A 4E00A 2IX6A 3CE2A 5M4KA 4Q1OA 1FS8A 2JBSA 2VIGA 1JM6A 4MPEA 2WBIA 4JEKA 2RFQA 3B96A 3OWAA 2OT4A 3RKHA 3SXQA 1Y8PA 3EOMA 2F6LA 2XS1A 1SIRA 2BU8A 2CJ6A 4AKHA 2YYJA 4H81A 4L3YA 4Q5CA 5M4PA 2Q8HA 3BNJA 2ZO5A 1GKXA 2R02A 2DVLA 4L3XA 4LQSB 4IV6A 2J7AA 2R0MA 5K3IA 2A1TA 3OWMA 5GJWE 3Q24A 1X91A 2E80A 3AFFA 4KSAA 3D9DA 4Q5BA 4X28A 4P79A 3Q23A 4OO2A 2OEXA 2JBTA 3VKGA 1RJ4A 2EBFX 1GKZA 2FONA 3D9EA 3II9A 2CJ7A 3C46A 4KCFA 3SWOA 5B6BA 4W9UA 2XS8A 3TZ4A 4XVXA 3X0YA 2CJ5A 3BNGA 2AZEA 5K3GA 2R0NA 2BU2A 4DOYA 1GJVA 4G5EA 3M9VA 4H85A 2ZDYA 2EBAA 1PI1A 1Y8NA 2OJQA 2ZKJA 3SCEA 5M4NA 2C0UA 4FF3A 3U33A 2D29A 4KS9A 1UDYA 4L38A 1JQIA 3BNFA 3NF4A 1XFYA 4Q4UA 2YYLA 4Q17A 4RM7A 2LFWA 2GBBA 4O5MA 2BTZA 4HKSA 4H7QA 1EGDA 2PO4A 1Y0VA 1K93A 4X28C 2CJ4A 4U83A 2YGWA 4V26A 3Q22A 1RP3A 4V25A 4FZ4A 2HJNA 5GJVE 3EONA 1X8ZA 3S7WA 4AKGA 2C12A 1FS9A 2Q8IA 4L3ZA 4ZXVA 4Q0TA 3TZ0A 1SC5A 3AFEA 3SF6A 4KSFA 1OAHA 3UBRA 2RDZA 2YYKA 2BU7A 2PG0A 2CJ8A 3FO3A 1FS7A 4N5FA 1IVHA 2UXWA 3P4TA 1K90A 4L1FA 1Y8OA 5J6AA 4FF4A 4MP2A 2REHA 1SK6A 1LVCA 4DZYA 5K3HA 2OR0A 1PK0A 4E02A 2BU5A 3GQTA 2XQRB 3TORA 1EGEA 3GNCA 1T9GA 3MPIA 2Q8GA 3MXLA
chains in the Genus database with same CATH topology
3MPJA 2RF7A 1QDBA 3MKHA 1UKWA 3UU9A 2CX9A 1R2JA 2IX5A 1BUCA 4KTOA 1EGCA 1W07A 4NXLA 2E81A 3D9GA 2YYMA 3LG1A 1SIQA 2YYGA 4M9AA 3D1IA 4ZYJA 3OIBA 2Z1QA 3L1TA 3GM6A 3BNHA 3MDDA 1WS9A 4P13A 3FCJA 3MMOA 2JIFA 1RX0A 4IRNA 4HR3A 3HWCA 3TTBA 2DDHA 5K3JA 2ZAFA 3MDEA 3F29A 2VR0A 3PFDA 3X0XA 3D9FA 4WJYA 2YYIA 3LGQA 2JBRA 1U8VA 3R7KA 3D6BA 1GU6A 1IS2A 2IX6A 4Q1OA 1FS8A 2JBSA 2VIGA 2OT4A 3RKHA 2WBIA 4JEKA 2RFQA 3B96A 3OWAA 3SXQA 3EOMA 1SIRA 2YYJA 4Q5CA 4L3YA 3BNJA 2ZO5A 2DVLA 4L3XA 4IV6A 2J7AA 2R0MA 5K3IA 2A1TA 3OWMA 2E80A 3AFFA 3D9DA 4Q5BA 4X28A 4OO2A 2JBTA 2FONA 3D9EA 3II9A 4KCFA 3SWOA 4W9UA 4XVXA 3X0YA 3BNGA 4G5EA 5K3GA 2R0NA 4DOYA 3M9VA 2EBAA 3SCEA 2C0UA 2D29A 1UDYA 4L38A 1JQIA 3BNFA 3NF4A 4Q4UA 2YYLA 4Q17A 4RM7A 4O5MA 1EGDA 4X28C 4U83A 3EONA 3S7WA 2C12A 1FS9A 4L3ZA 4ZXVA 4Q0TA 3AFEA 3SF6A 1OAHA 3UBRA 2RDZA 2YYKA 2PG0A 3FO3A 1FS7A 4N5FA 1IVHA 2UXWA 3P4TA 4L1FA 2REHA 5K3HA 2OR0A 3GQTA 3TORA 1EGEA 3GNCA 1T9GA 3MPIA 3MXLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MPJ A;  2RF7 A;  1QDB A;  3MKH A;  1UKW A;  3UU9 A;  2CX9 A;  1R2J A;  2IX5 A;  1BUC A;  4KTO A;  1EGC A;  1W07 A;  4NXL A;  2E81 A;  3D9G A;  2YYM A;  3LG1 A;  1SIQ A;  2YYG A;  4M9A A;  3D1I A;  4ZYJ A;  3OIB A;  2Z1Q A;  3L1T A;  3GM6 A;  3BNH A;  3MDD A;  1WS9 A;  4P13 A;  3FCJ A;  3MMO A;  2JIF A;  1RX0 A;  4IRN A;  4HR3 A;  3HWC A;  3TTB A;  2DDH A;  5K3J A;  2ZAF A;  3MDE A;  3F29 A;  2VR0 A;  3PFD A;  3X0X A;  3D9F A;  4WJY A;  2YYI A;  3LGQ A;  2JBR A;  1U8V A;  3R7K A;  3D6B A;  1GU6 A;  1IS2 A;  2IX6 A;  4Q1O A;  1FS8 A;  2JBS A;  2VIG A;  2OT4 A;  3RKH A;  2WBI A;  4JEK A;  2RFQ A;  3B96 A;  3OWA A;  3SXQ A;  3EOM A;  1SIR A;  2YYJ A;  4Q5C A;  4L3Y A;  3BNJ A;  2ZO5 A;  2DVL A;  4L3X A;  4IV6 A;  2J7A A;  2R0M A;  5K3I A;  2A1T A;  3OWM A;  2E80 A;  3AFF A;  3D9D A;  4Q5B A;  4X28 A;  4OO2 A;  2JBT A;  2FON A;  3D9E A;  3II9 A;  4KCF A;  3SWO A;  4W9U A;  4XVX A;  3X0Y A;  3BNG A;  4G5E A;  5K3G A;  2R0N A;  4DOY A;  3M9V A;  2EBA A;  3SCE A;  2C0U A;  2D29 A;  1UDY A;  4L38 A;  1JQI A;  3BNF A;  3NF4 A;  4Q4U A;  2YYL A;  4Q17 A;  4RM7 A;  4O5M A;  1EGD A;  4X28 C;  4U83 A;  3EON A;  3S7W A;  2C12 A;  1FS9 A;  4L3Z A;  4ZXV A;  4Q0T A;  3AFE A;  3SF6 A;  1OAH A;  3UBR A;  2RDZ A;  2YYK A;  2PG0 A;  3FO3 A;  1FS7 A;  4N5F A;  1IVH A;  2UXW A;  3P4T A;  4L1F A;  2REH A;  5K3H A;  2OR0 A;  3GQT A;  3TOR A;  1EGE A;  3GNC A;  1T9G A;  3MPI A;  3MXL A; 
#chains in the Genus database with same CATH topology
 4LQQ B;  5B5V A;  3MPJ A;  2E0A A;  1X90 A;  2RF7 A;  2OEV A;  4AI6 A;  5BRM A;  3KML A;  1QDB A;  3N0R A;  3CRL A;  3MKH A;  1UKW A;  3UU9 A;  3VKH A;  2CX9 A;  1R2J A;  4MPN A;  2VF1 A;  4J1V A;  1K8T A;  2IX5 A;  1BUC A;  4KTO A;  1EGC A;  1W07 A;  4NXL A;  1RJ1 A;  3D9G A;  2E81 A;  1XFV A;  2R03 A;  2YYM A;  1R3B A;  2EBH X;  3CRK A;  3LG1 A;  1XFU A;  3VAD A;  2PNR A;  1SIQ A;  4F0X A;  5M4M A;  2YYG A;  4M9A A;  3D1I A;  1S26 A;  2Q8F A;  5EZ3 A;  4ZYJ A;  3OIB A;  2Z1Q A;  3L1T A;  2BU6 A;  4HKR A;  3DJL A;  3GM6 A;  3BNH A;  3C3L A;  1XFX A;  2AO2 A;  3MDD A;  3X29 A;  5B5W A;  3Q0A A;  4JIZ A;  1WS9 A;  3TZ2 A;  2FP1 A;  4P13 A;  3FCJ A;  4MPC A;  3MMO A;  2JIF A;  4FF1 A;  1RX0 A;  4IRN A;  4HR3 A;  1XFW A;  2ZDX A;  3HWC A;  3TTB A;  2DDH A;  5K3J A;  2ZAF A;  3MDE A;  4G97 A;  3F29 A;  5J71 A;  4FF2 A;  1XFZ A;  2VR0 A;  3D2R A;  3PFD A;  3X0X A;  3C2P A;  3D9F A;  4WJY A;  4AKI A;  4E01 A;  4MP7 A;  2YYI A;  3LGQ A;  2JBR A;  1U8V A;  3R7K A;  3D6B A;  2FP2 A;  4QIC A;  4JIO A;  3TZ5 A;  1GU6 A;  5BRK A;  1IS2 A;  2QR4 A;  2R05 A;  1XG2 B;  2EC5 A;  4E00 A;  2IX6 A;  3CE2 A;  5M4K A;  4Q1O A;  1FS8 A;  2JBS A;  2VIG A;  1JM6 A;  4MPE A;  2WBI A;  4JEK A;  2RFQ A;  3B96 A;  3OWA A;  2OT4 A;  3RKH A;  3SXQ A;  1Y8P A;  3EOM A;  2F6L A;  2XS1 A;  1SIR A;  2BU8 A;  2CJ6 A;  4AKH A;  2YYJ A;  4H81 A;  4L3Y A;  4Q5C A;  5M4P A;  2Q8H A;  3BNJ A;  2ZO5 A;  1GKX A;  2R02 A;  2DVL A;  4L3X A;  4LQS B;  4IV6 A;  2J7A A;  2R0M A;  5K3I A;  2A1T A;  3OWM A;  5GJW E;  3Q24 A;  1X91 A;  2E80 A;  3AFF A;  4KSA A;  3D9D A;  4Q5B A;  4X28 A;  4P79 A;  3Q23 A;  4OO2 A;  2OEX A;  2JBT A;  3VKG A;  1RJ4 A;  2EBF X;  1GKZ A;  2FON A;  3D9E A;  3II9 A;  2CJ7 A;  3C46 A;  4KCF A;  3SWO A;  5B6B A;  4W9U A;  2XS8 A;  3TZ4 A;  4XVX A;  3X0Y A;  2CJ5 A;  3BNG A;  2AZE A;  5K3G A;  2R0N A;  2BU2 A;  4DOY A;  1GJV A;  4G5E A;  3M9V A;  4H85 A;  2ZDY A;  2EBA A;  1PI1 A;  1Y8N A;  2OJQ A;  2ZKJ A;  3SCE A;  5M4N A;  2C0U A;  4FF3 A;  3U33 A;  2D29 A;  4KS9 A;  1UDY A;  4L38 A;  1JQI A;  3BNF A;  3NF4 A;  1XFY A;  4Q4U A;  2YYL A;  4Q17 A;  4RM7 A;  2LFW A;  2GBB A;  4O5M A;  2BTZ A;  4HKS A;  4H7Q A;  1EGD A;  2PO4 A;  1Y0V A;  1K93 A;  4X28 C;  2CJ4 A;  4U83 A;  2YGW A;  4V26 A;  3Q22 A;  1RP3 A;  4V25 A;  4FZ4 A;  2HJN A;  5GJV E;  3EON A;  1X8Z A;  3S7W A;  4AKG A;  2C12 A;  1FS9 A;  2Q8I A;  4L3Z A;  4ZXV A;  4Q0T A;  3TZ0 A;  1SC5 A;  3AFE A;  3SF6 A;  4KSF A;  1OAH A;  3UBR A;  2RDZ A;  2YYK A;  2BU7 A;  2PG0 A;  2CJ8 A;  3FO3 A;  1FS7 A;  4N5F A;  1IVH A;  2UXW A;  3P4T A;  1K90 A;  4L1F A;  1Y8O A;  5J6A A;  4FF4 A;  4MP2 A;  2REH A;  1SK6 A;  1LVC A;  4DZY A;  5K3H A;  2OR0 A;  1PK0 A;  4E02 A;  2BU5 A;  3GQT A;  2XQR B;  3TOR A;  1EGE A;  3GNC A;  1T9G A;  3MPI A;  2Q8G A;  3MXL A; 
#chains in the Genus database with same CATH homology
 3MPJ A;  2RF7 A;  1QDB A;  3MKH A;  1UKW A;  3UU9 A;  2CX9 A;  1R2J A;  2IX5 A;  1BUC A;  4KTO A;  1EGC A;  1W07 A;  4NXL A;  2E81 A;  3D9G A;  2YYM A;  3LG1 A;  1SIQ A;  2YYG A;  4M9A A;  3D1I A;  4ZYJ A;  3OIB A;  2Z1Q A;  3L1T A;  3GM6 A;  3BNH A;  3MDD A;  1WS9 A;  4P13 A;  3FCJ A;  3MMO A;  2JIF A;  1RX0 A;  4IRN A;  4HR3 A;  3HWC A;  3TTB A;  2DDH A;  5K3J A;  2ZAF A;  3MDE A;  3F29 A;  2VR0 A;  3PFD A;  3X0X A;  3D9F A;  4WJY A;  2YYI A;  3LGQ A;  2JBR A;  1U8V A;  3R7K A;  3D6B A;  1GU6 A;  1IS2 A;  2IX6 A;  4Q1O A;  1FS8 A;  2JBS A;  2VIG A;  2OT4 A;  3RKH A;  2WBI A;  4JEK A;  2RFQ A;  3B96 A;  3OWA A;  3SXQ A;  3EOM A;  1SIR A;  2YYJ A;  4Q5C A;  4L3Y A;  3BNJ A;  2ZO5 A;  2DVL A;  4L3X A;  4IV6 A;  2J7A A;  2R0M A;  5K3I A;  2A1T A;  3OWM A;  2E80 A;  3AFF A;  3D9D A;  4Q5B A;  4X28 A;  4OO2 A;  2JBT A;  2FON A;  3D9E A;  3II9 A;  4KCF A;  3SWO A;  4W9U A;  4XVX A;  3X0Y A;  3BNG A;  4G5E A;  5K3G A;  2R0N A;  4DOY A;  3M9V A;  2EBA A;  3SCE A;  2C0U A;  2D29 A;  1UDY A;  4L38 A;  1JQI A;  3BNF A;  3NF4 A;  4Q4U A;  2YYL A;  4Q17 A;  4RM7 A;  4O5M A;  1EGD A;  4X28 C;  4U83 A;  3EON A;  3S7W A;  2C12 A;  1FS9 A;  4L3Z A;  4ZXV A;  4Q0T A;  3AFE A;  3SF6 A;  1OAH A;  3UBR A;  2RDZ A;  2YYK A;  2PG0 A;  3FO3 A;  1FS7 A;  4N5F A;  1IVH A;  2UXW A;  3P4T A;  4L1F A;  2REH A;  5K3H A;  2OR0 A;  3GQT A;  3TOR A;  1EGE A;  3GNC A;  1T9G A;  3MPI A;  3MXL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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