3NF4A

Crystal structure of acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to flavin adenine dinucleotide
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
378
structure length
369
Chain Sequence
MAVDRLLPSQEAAELIELTREIADKVLDPIVDRHEKDETYPEGVFEQLGAAGLLSLPQPEEWGGGGQPYEVYLQVLEEIAARWASVAVAVSVHSLSSHPLLVFGTEEQKKRWLPGMLSGEQIGAYSLSEPQAGSDAAALRCAATPTDGGYVINGSKSWITHGGKADFYTLFARTGSRGVSCFLVPADQPGLSFGKPEEKMGLHAVPTTSAFYDNARIDADRRIGEEGQGLQIAFSALDSGRLGIAAVATGLAQAALDEAVAYANEKIIDHGLGFLLADMAAAVATARATYLDAARRRDQGRPYSQQASIAKLTATDAAMKVTTDAVQVFGGVGYTRDYRVERYMREAKIMQIFEGTNQIQRLVIARGLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords acyl-CoA dehydrogenase
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium thermoresistibile
total genus 127
structure length 369
sequence length 378
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 3nf4A01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3nf4A03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 3nf4A02
2VR0A 2R0MA 2ZAFA 4ZYJA 3BNHA 3BNJA 3D9EA 3FO3A 3BNFA 3MDEA 3AFEA 3LGQA 3TTBA 5K3GA 1FS8A 4U83A 3B96A 3P4TA 3HWCA 2YYGA 3SWOA 1T9GA 1U8VA 1JQIA 3OWAA 1SIRA 2J7AA 2REHA 3D9DA 2IX5A 3EONA 1OAHA 2RF7A 4Q1OA 2C12A 3SXQA 3SF6A 2IX6A 2WBIA 2VIGA 4Q0TA 3RKHA 3D1IA 4L3ZA 4O5MA 1FS7A 4IRNA 1BUCA 2EBAA 4X28A 4L1FA 2YYJA 4NXLA 4JEKA 1EGDA 4XVXA 3LG1A 2YYLA 3FCJA 3OIBA 1GU6A 2C0UA 4KCFA 3M9VA 2DDHA 4L3YA 1UDYA 4W9UA 3BNGA 1RX0A 2CX9A 2FONA 3D9GA 3S7WA 3NF4A 2A1TA 3PFDA 2JBRA 2PG0A 2E81A 3MPJA 3EOMA 4RM7A 4X28C 4OO2A 2RDZA 1IS2A 2UXWA 1W07A 4P13A 2DVLA 3GQTA 5K3JA 3MMOA 4KTOA 1QDBA 2ZO5A 1FS9A 3GNCA 2RFQA 3GM6A 4Q5CA 2OR0A 4N5FA 4M9AA 2YYIA 3X0XA 3D9FA 3R7KA 3L1TA 2YYMA 3OWMA 4L3XA 3MDDA 2E80A 3AFFA 3MXLA 2JBTA 2OT4A 3SCEA 2R0NA 5K3IA 3X0YA 1WS9A 4Q17A 3UU9A 1IVHA 3TORA 4L38A 4ZXVA 3D6BA 1R2JA 2D29A 4HR3A 4Q4UA 4DOYA 4G5EA 1UKWA 2JIFA 3MKHA 3F29A 2YYKA 2JBSA 5K3HA 3MPIA 1EGEA 4IV6A 4WJYA 2Z1QA 4Q5BA 3II9A 3UBRA 1SIQA 1EGCA
chains in the Genus database with same CATH superfamily
2QR4A 1K93A 2R0MA 2ZAFA 2PNRA 2VR0A 4ZYJA 1SC5A 5M4PA 2FP1A 3BNHA 4FF3A 3BNJA 1XFYA 2CJ4A 3D9EA 4E01A 3FO3A 1PI1A 2XS8A 5B5VA 3BNFA 3MDEA 3AFEA 3LGQA 3TTBA 5K3GA 1FS8A 2BTZA 1RJ4A 2YGWA 3Q0AA 2AO2A 1X91A 4U83A 3B96A 2CJ5A 1GKZA 3P4TA 2OEVA 3HWCA 3TZ5A 4FZ4A 2YYGA 3SWOA 1T9GA 1U8VA 4KSFA 1JQIA 3OWAA 1SIRA 2J7AA 2REHA 3D9DA 2IX5A 3EONA 1OAHA 2RF7A 4Q1OA 2C12A 3SXQA 4G97A 3SF6A 1JM6A 4LQSB 2IX6A 2WBIA 2VIGA 2R02A 1Y0VA 4Q0TA 1Y8PA 2XS1A 3D2RA 4V26A 2Q8IA 3RKHA 2CJ8A 1XG2B 3D1IA 4L3ZA 4P79A 2R03A 4QICA 4O5MA 1FS7A 4IRNA 1BUCA 2EBAA 2EBHX 4X28A 4H81A 4KS9A 2Q8HA 5J71A 4L1FA 1GJVA 2YYJA 4NXLA 3DJLA 2LFWA 5M4MA 3Q24A 4MPCA 4JEKA 1EGDA 4XVXA 4V25A 4DZYA 1XFVA 3LG1A 2YYLA 4LQQB 3FCJA 2Q8GA 3C2PA 4FF4A 3OIBA 1GU6A 2OJQA 2C0UA 4KCFA 3M9VA 2DDHA 2BU7A 2ZDXA 4L3YA 2VF1A 5GJVE 4E00A 5GJWE 1UDYA 4W9UA 4AKIA 3BNGA 1RX0A 2CX9A 2FONA 3D9GA 2OEXA 3NF4A 3S7WA 2A1TA 2CJ6A 3X29A 2BU2A 3PFDA 4J1VA 5BRKA 2JBRA 2PG0A 2E81A 2HJNA 2GBBA 3CE2A 3MPJA 3EOMA 5M4NA 4RM7A 4X28C 4OO2A 4H85A 2RDZA 1IS2A 2UXWA 1W07A 4P13A 2DVLA 3GQTA 5K3JA 3MMOA 2BU8A 2ZDYA 2BU5A 3C46A 4KTOA 3CRLA 5B6BA 3U33A 1QDBA 2BU6A 2ZO5A 3TZ4A 2CJ7A 1FS9A 3N0RA 3GNCA 3Q23A 4HKRA 2RFQA 3GM6A 4Q5CA 1X8ZA 1XFZA 2OR0A 1PK0A 3KMLA 1K8TA 2FP2A 4KSAA 1XFWA 4N5FA 1XFXA 2EBFX 3CRKA 4MPNA 4M9AA 2Q8FA 2YYIA 3X0XA 3D9FA 3R7KA 3L1TA 2YYMA 3OWMA 4HKSA 4L3XA 3VADA 1R3BA 5J6AA 5EZ3A 3MDDA 2E80A 5M4KA 3AFFA 3MXLA 1X90A 4E02A 2JBTA 2OT4A 3SCEA 2R0NA 2ZKJA 5K3IA 2XQRB 3X0YA 2F6LA 1WS9A 4Q17A 1Y8OA 3UU9A 2AZEA 4FF1A 1IVHA 3TORA 4L38A 4AKGA 4ZXVA 3D6BA 3TZ0A 1XFUA 1R2JA 2D29A 4HR3A 4Q4UA 4DOYA 1SK6A 4G5EA 4JIZA 1Y8NA 1UKWA 2JIFA 3MKHA 3F29A 4AKHA 2R05A 3Q22A 4MP7A 2YYKA 1RJ1A 1GKXA 4AI6A 4MP2A 1K90A 4MPEA 5BRMA 2JBSA 4JIOA 3VKGA 3TZ2A 2PO4A 5K3HA 2EC5A 5B5WA 3MPIA 1EGEA 4IV6A 1LVCA 4WJYA 2E0AA 2Z1QA 4Q5BA 3VKHA 3II9A 3UBRA 4F0XA 1SIQA 4H7QA 4FF2A 1RP3A 3C3LA 1S26A 1EGCA
chains in the Genus database with same CATH topology
2VR0A 2R0MA 2ZAFA 4ZYJA 3BNHA 3BNJA 3D9EA 3FO3A 3BNFA 3MDEA 3AFEA 3LGQA 3TTBA 5K3GA 1FS8A 4U83A 3B96A 3P4TA 3HWCA 2YYGA 3SWOA 1T9GA 1U8VA 1JQIA 3OWAA 1SIRA 2J7AA 2REHA 3D9DA 2IX5A 3EONA 1OAHA 2RF7A 4Q1OA 2C12A 3SXQA 3SF6A 2IX6A 2WBIA 2VIGA 4Q0TA 3RKHA 3D1IA 4L3ZA 4O5MA 1FS7A 4IRNA 1BUCA 2EBAA 4X28A 4L1FA 2YYJA 4NXLA 4JEKA 1EGDA 4XVXA 3LG1A 2YYLA 3FCJA 3OIBA 1GU6A 2C0UA 4KCFA 3M9VA 2DDHA 4L3YA 1UDYA 4W9UA 3BNGA 1RX0A 2CX9A 2FONA 3D9GA 3S7WA 3NF4A 2A1TA 3PFDA 2JBRA 2PG0A 2E81A 3MPJA 3EOMA 4RM7A 4X28C 4OO2A 2RDZA 1IS2A 2UXWA 1W07A 4P13A 2DVLA 3GQTA 5K3JA 3MMOA 4KTOA 1QDBA 2ZO5A 1FS9A 3GNCA 2RFQA 3GM6A 4Q5CA 2OR0A 4N5FA 4M9AA 2YYIA 3X0XA 3D9FA 3R7KA 3L1TA 2YYMA 3OWMA 4L3XA 3MDDA 2E80A 3AFFA 3MXLA 2JBTA 2OT4A 3SCEA 2R0NA 5K3IA 3X0YA 1WS9A 4Q17A 3UU9A 1IVHA 3TORA 4L38A 4ZXVA 3D6BA 1R2JA 2D29A 4HR3A 4Q4UA 4DOYA 4G5EA 1UKWA 2JIFA 3MKHA 3F29A 2YYKA 2JBSA 5K3HA 3MPIA 1EGEA 4IV6A 4WJYA 2Z1QA 4Q5BA 3II9A 3UBRA 1SIQA 1EGCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VR0 A;  2R0M A;  2ZAF A;  4ZYJ A;  3BNH A;  3BNJ A;  3D9E A;  3FO3 A;  3BNF A;  3MDE A;  3AFE A;  3LGQ A;  3TTB A;  5K3G A;  1FS8 A;  4U83 A;  3B96 A;  3P4T A;  3HWC A;  2YYG A;  3SWO A;  1T9G A;  1U8V A;  1JQI A;  3OWA A;  1SIR A;  2J7A A;  2REH A;  3D9D A;  2IX5 A;  3EON A;  1OAH A;  2RF7 A;  4Q1O A;  2C12 A;  3SXQ A;  3SF6 A;  2IX6 A;  2WBI A;  2VIG A;  4Q0T A;  3RKH A;  3D1I A;  4L3Z A;  4O5M A;  1FS7 A;  4IRN A;  1BUC A;  2EBA A;  4X28 A;  4L1F A;  2YYJ A;  4NXL A;  4JEK A;  1EGD A;  4XVX A;  3LG1 A;  2YYL A;  3FCJ A;  3OIB A;  1GU6 A;  2C0U A;  4KCF A;  3M9V A;  2DDH A;  4L3Y A;  1UDY A;  4W9U A;  3BNG A;  1RX0 A;  2CX9 A;  2FON A;  3D9G A;  3S7W A;  3NF4 A;  2A1T A;  3PFD A;  2JBR A;  2PG0 A;  2E81 A;  3MPJ A;  3EOM A;  4RM7 A;  4X28 C;  4OO2 A;  2RDZ A;  1IS2 A;  2UXW A;  1W07 A;  4P13 A;  2DVL A;  3GQT A;  5K3J A;  3MMO A;  4KTO A;  1QDB A;  2ZO5 A;  1FS9 A;  3GNC A;  2RFQ A;  3GM6 A;  4Q5C A;  2OR0 A;  4N5F A;  4M9A A;  2YYI A;  3X0X A;  3D9F A;  3R7K A;  3L1T A;  2YYM A;  3OWM A;  4L3X A;  3MDD A;  2E80 A;  3AFF A;  3MXL A;  2JBT A;  2OT4 A;  3SCE A;  2R0N A;  5K3I A;  3X0Y A;  1WS9 A;  4Q17 A;  3UU9 A;  1IVH A;  3TOR A;  4L38 A;  4ZXV A;  3D6B A;  1R2J A;  2D29 A;  4HR3 A;  4Q4U A;  4DOY A;  4G5E A;  1UKW A;  2JIF A;  3MKH A;  3F29 A;  2YYK A;  2JBS A;  5K3H A;  3MPI A;  1EGE A;  4IV6 A;  4WJY A;  2Z1Q A;  4Q5B A;  3II9 A;  3UBR A;  1SIQ A;  1EGC A; 
#chains in the Genus database with same CATH topology
 2QR4 A;  1K93 A;  2R0M A;  2ZAF A;  2PNR A;  2VR0 A;  4ZYJ A;  1SC5 A;  5M4P A;  2FP1 A;  3BNH A;  4FF3 A;  3BNJ A;  1XFY A;  2CJ4 A;  3D9E A;  4E01 A;  3FO3 A;  1PI1 A;  2XS8 A;  5B5V A;  3BNF A;  3MDE A;  3AFE A;  3LGQ A;  3TTB A;  5K3G A;  1FS8 A;  2BTZ A;  1RJ4 A;  2YGW A;  3Q0A A;  2AO2 A;  1X91 A;  4U83 A;  3B96 A;  2CJ5 A;  1GKZ A;  3P4T A;  2OEV A;  3HWC A;  3TZ5 A;  4FZ4 A;  2YYG A;  3SWO A;  1T9G A;  1U8V A;  4KSF A;  1JQI A;  3OWA A;  1SIR A;  2J7A A;  2REH A;  3D9D A;  2IX5 A;  3EON A;  1OAH A;  2RF7 A;  4Q1O A;  2C12 A;  3SXQ A;  4G97 A;  3SF6 A;  1JM6 A;  4LQS B;  2IX6 A;  2WBI A;  2VIG A;  2R02 A;  1Y0V A;  4Q0T A;  1Y8P A;  2XS1 A;  3D2R A;  4V26 A;  2Q8I A;  3RKH A;  2CJ8 A;  1XG2 B;  3D1I A;  4L3Z A;  4P79 A;  2R03 A;  4QIC A;  4O5M A;  1FS7 A;  4IRN A;  1BUC A;  2EBA A;  2EBH X;  4X28 A;  4H81 A;  4KS9 A;  2Q8H A;  5J71 A;  4L1F A;  1GJV A;  2YYJ A;  4NXL A;  3DJL A;  2LFW A;  5M4M A;  3Q24 A;  4MPC A;  4JEK A;  1EGD A;  4XVX A;  4V25 A;  4DZY A;  1XFV A;  3LG1 A;  2YYL A;  4LQQ B;  3FCJ A;  2Q8G A;  3C2P A;  4FF4 A;  3OIB A;  1GU6 A;  2OJQ A;  2C0U A;  4KCF A;  3M9V A;  2DDH A;  2BU7 A;  2ZDX A;  4L3Y A;  2VF1 A;  5GJV E;  4E00 A;  5GJW E;  1UDY A;  4W9U A;  4AKI A;  3BNG A;  1RX0 A;  2CX9 A;  2FON A;  3D9G A;  2OEX A;  3NF4 A;  3S7W A;  2A1T A;  2CJ6 A;  3X29 A;  2BU2 A;  3PFD A;  4J1V A;  5BRK A;  2JBR A;  2PG0 A;  2E81 A;  2HJN A;  2GBB A;  3CE2 A;  3MPJ A;  3EOM A;  5M4N A;  4RM7 A;  4X28 C;  4OO2 A;  4H85 A;  2RDZ A;  1IS2 A;  2UXW A;  1W07 A;  4P13 A;  2DVL A;  3GQT A;  5K3J A;  3MMO A;  2BU8 A;  2ZDY A;  2BU5 A;  3C46 A;  4KTO A;  3CRL A;  5B6B A;  3U33 A;  1QDB A;  2BU6 A;  2ZO5 A;  3TZ4 A;  2CJ7 A;  1FS9 A;  3N0R A;  3GNC A;  3Q23 A;  4HKR A;  2RFQ A;  3GM6 A;  4Q5C A;  1X8Z A;  1XFZ A;  2OR0 A;  1PK0 A;  3KML A;  1K8T A;  2FP2 A;  4KSA A;  1XFW A;  4N5F A;  1XFX A;  2EBF X;  3CRK A;  4MPN A;  4M9A A;  2Q8F A;  2YYI A;  3X0X A;  3D9F A;  3R7K A;  3L1T A;  2YYM A;  3OWM A;  4HKS A;  4L3X A;  3VAD A;  1R3B A;  5J6A A;  5EZ3 A;  3MDD A;  2E80 A;  5M4K A;  3AFF A;  3MXL A;  1X90 A;  4E02 A;  2JBT A;  2OT4 A;  3SCE A;  2R0N A;  2ZKJ A;  5K3I A;  2XQR B;  3X0Y A;  2F6L A;  1WS9 A;  4Q17 A;  1Y8O A;  3UU9 A;  2AZE A;  4FF1 A;  1IVH A;  3TOR A;  4L38 A;  4AKG A;  4ZXV A;  3D6B A;  3TZ0 A;  1XFU A;  1R2J A;  2D29 A;  4HR3 A;  4Q4U A;  4DOY A;  1SK6 A;  4G5E A;  4JIZ A;  1Y8N A;  1UKW A;  2JIF A;  3MKH A;  3F29 A;  4AKH A;  2R05 A;  3Q22 A;  4MP7 A;  2YYK A;  1RJ1 A;  1GKX A;  4AI6 A;  4MP2 A;  1K90 A;  4MPE A;  5BRM A;  2JBS A;  4JIO A;  3VKG A;  3TZ2 A;  2PO4 A;  5K3H A;  2EC5 A;  5B5W A;  3MPI A;  1EGE A;  4IV6 A;  1LVC A;  4WJY A;  2E0A A;  2Z1Q A;  4Q5B A;  3VKH A;  3II9 A;  3UBR A;  4F0X A;  1SIQ A;  4H7Q A;  4FF2 A;  1RP3 A;  3C3L A;  1S26 A;  1EGC A; 
#chains in the Genus database with same CATH homology
 2VR0 A;  2R0M A;  2ZAF A;  4ZYJ A;  3BNH A;  3BNJ A;  3D9E A;  3FO3 A;  3BNF A;  3MDE A;  3AFE A;  3LGQ A;  3TTB A;  5K3G A;  1FS8 A;  4U83 A;  3B96 A;  3P4T A;  3HWC A;  2YYG A;  3SWO A;  1T9G A;  1U8V A;  1JQI A;  3OWA A;  1SIR A;  2J7A A;  2REH A;  3D9D A;  2IX5 A;  3EON A;  1OAH A;  2RF7 A;  4Q1O A;  2C12 A;  3SXQ A;  3SF6 A;  2IX6 A;  2WBI A;  2VIG A;  4Q0T A;  3RKH A;  3D1I A;  4L3Z A;  4O5M A;  1FS7 A;  4IRN A;  1BUC A;  2EBA A;  4X28 A;  4L1F A;  2YYJ A;  4NXL A;  4JEK A;  1EGD A;  4XVX A;  3LG1 A;  2YYL A;  3FCJ A;  3OIB A;  1GU6 A;  2C0U A;  4KCF A;  3M9V A;  2DDH A;  4L3Y A;  1UDY A;  4W9U A;  3BNG A;  1RX0 A;  2CX9 A;  2FON A;  3D9G A;  3S7W A;  3NF4 A;  2A1T A;  3PFD A;  2JBR A;  2PG0 A;  2E81 A;  3MPJ A;  3EOM A;  4RM7 A;  4X28 C;  4OO2 A;  2RDZ A;  1IS2 A;  2UXW A;  1W07 A;  4P13 A;  2DVL A;  3GQT A;  5K3J A;  3MMO A;  4KTO A;  1QDB A;  2ZO5 A;  1FS9 A;  3GNC A;  2RFQ A;  3GM6 A;  4Q5C A;  2OR0 A;  4N5F A;  4M9A A;  2YYI A;  3X0X A;  3D9F A;  3R7K A;  3L1T A;  2YYM A;  3OWM A;  4L3X A;  3MDD A;  2E80 A;  3AFF A;  3MXL A;  2JBT A;  2OT4 A;  3SCE A;  2R0N A;  5K3I A;  3X0Y A;  1WS9 A;  4Q17 A;  3UU9 A;  1IVH A;  3TOR A;  4L38 A;  4ZXV A;  3D6B A;  1R2J A;  2D29 A;  4HR3 A;  4Q4U A;  4DOY A;  4G5E A;  1UKW A;  2JIF A;  3MKH A;  3F29 A;  2YYK A;  2JBS A;  5K3H A;  3MPI A;  1EGE A;  4IV6 A;  4WJY A;  2Z1Q A;  4Q5B A;  3II9 A;  3UBR A;  1SIQ A;  1EGC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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