1SIQA

The crystal structure and mechanism of human glutaryl-coa dehydrogenase
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
390
structure length
390
Chain Sequence
EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutaryl-CoA dehydrogenase
publication title Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions
pubmed doi rcsb
molecule tags Oxidoreductase
total genus 151
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2004-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1siqA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1siqA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1siqA02
1JQIA 3R7KA 2C0UA 2J7AA 2ZO5A 2YYMA 4G5EA 3TORA 3SF6A 3FCJA 2D29A 1RX0A 1W07A 4O5MA 3EOMA 4ZYJA 4L38A 3AFFA 3P4TA 3M9VA 4L3XA 3OWMA 1GU6A 5K3HA 2YYLA 2JBTA 4Q17A 3D6BA 4U83A 4KTOA 2IX6A 2Z1QA 5K3JA 3UBRA 2E81A 3BNGA 2UXWA 2RFQA 1T9GA 3AFEA 3SCEA 3D9EA 3OIBA 3GM6A 3S7WA 1EGDA 2JBSA 5K3GA 1QDBA 4Q4UA 3LG1A 1FS8A 4Q1OA 3TTBA 3D9FA 2CX9A 2PG0A 2VR0A 2DDHA 3BNJA 2JBRA 3HWCA 2R0NA 4NXLA 4P13A 1WS9A 4L3YA 3D9DA 3SXQA 3MPIA 3X0XA 4Q0TA 1SIQA 1FS7A 3MKHA 1BUCA 3OWAA 4L1FA 1OAHA 4DOYA 2YYKA 2DVLA 4ZXVA 2EBAA 3B96A 3EONA 4OO2A 1EGCA 3D9GA 2VIGA 3NF4A 2REHA 3MXLA 1IS2A 3MPJA 2ZAFA 3GNCA 4Q5BA 4IV6A 4WJYA 4M9AA 1R2JA 3D1IA 2IX5A 4RM7A 3F29A 4W9UA 4X28A 1SIRA 2OR0A 3RKHA 2E80A 4HR3A 4JEKA 3GQTA 4X28C 3BNHA 3X0YA 1UDYA 5K3IA 3L1TA 3MDDA 1UKWA 3II9A 3LGQA 4Q5CA 2C12A 3MDEA 2RF7A 4KCFA 3MMOA 2WBIA 2YYIA 4N5FA 2R0MA 3FO3A 4L3ZA 1FS9A 4IRNA 2FONA 2YYJA 1EGEA 4XVXA 3UU9A 1IVHA 2YYGA 2JIFA 1U8VA 2OT4A 3SWOA 2A1TA 3PFDA 3BNFA 2RDZA
chains in the Genus database with same CATH superfamily
1JQIA 1XFYA 2OEXA 4DZYA 3R7KA 1XFVA 4E00A 5M4KA 5B5WA 2C0UA 2ZDXA 2J7AA 2ZO5A 4HKSA 3VKGA 2YYMA 4G5EA 3TORA 3SF6A 4MPEA 4E01A 1Y8NA 3FCJA 1XFXA 2D29A 1RX0A 2FP1A 1W07A 4O5MA 3EOMA 4ZYJA 2ZDYA 3AFFA 4H7QA 4L38A 2Q8FA 3P4TA 2OJQA 3M9VA 2PNRA 4L3XA 2VF1A 3OWMA 1GU6A 4MP7A 3TZ5A 1GJVA 4FF1A 5K3HA 4AKHA 5EZ3A 2YYLA 2EBHX 1R3BA 2ZKJA 4KS9A 3DJLA 2JBTA 3Q22A 4Q17A 3D6BA 4U83A 4KTOA 3CRKA 3Q23A 2IX6A 2CJ4A 2Z1QA 5K3JA 3UBRA 2E81A 3BNGA 2UXWA 2RFQA 1T9GA 3AFEA 1RP3A 3SCEA 4FF4A 3D9EA 3X29A 4FZ4A 4KSAA 3OIBA 2CJ5A 3GM6A 3S7WA 1EGDA 2R05A 2JBSA 4QICA 5K3GA 2YGWA 1QDBA 2OEVA 4Q4UA 3LG1A 1SK6A 1FS8A 1LVCA 2QR4A 4Q1OA 3D9FA 3TTBA 3C3LA 1XFZA 3VKHA 3U33A 1GKZA 2CX9A 2PG0A 2VR0A 2CJ6A 3Q0AA 2DDHA 4JIZA 5B5VA 3BNJA 2JBRA 1RJ1A 2R0NA 3HWCA 4NXLA 4P13A 1WS9A 4L3YA 3D9DA 1S26A 3SXQA 2HJNA 4KSFA 3MPIA 3X0XA 2CJ7A 2FP2A 5M4PA 4Q0TA 5J71A 4FF3A 1SIQA 1X90A 2LFWA 4E02A 1FS7A 3MKHA 1BUCA 3OWAA 5GJVE 4L1FA 1OAHA 4DOYA 3TZ4A 2YYKA 1K8TA 1K90A 4F0XA 2DVLA 4MP2A 1GKXA 4ZXVA 2EBAA 3B96A 3EONA 1Y8PA 2BU8A 2XS1A 3KMLA 1EGCA 4OO2A 3D9GA 2VIGA 3NF4A 4FF2A 2REHA 2Q8GA 3MXLA 3TZ2A 2Q8IA 4H81A 1IS2A 3MPJA 2ZAFA 2BTZA 1K93A 3C2PA 3C46A 3GNCA 4Q5BA 4IV6A 2AZEA 4WJYA 2R02A 4M9AA 1R2JA 3D1IA 4AKGA 4G97A 2IX5A 4RM7A 3F29A 4W9UA 2CJ8A 2EC5A 2R03A 4X28A 1SIRA 2XS8A 4HKRA 1PI1A 2OR0A 1SC5A 2BU2A 3CE2A 4J1VA 4MPCA 1PK0A 3RKHA 3VADA 4H85A 4V26A 2E80A 4LQSB 4HR3A 4JEKA 3Q24A 3GQTA 5BRKA 4AI6A 4X28C 3BNHA 4MPNA 2BU6A 3X0YA 1UDYA 5K3IA 3L1TA 1XG2B 3MDDA 4JIOA 1UKWA 3TZ0A 3II9A 5B6BA 3LGQA 4Q5CA 2C12A 2BU5A 5M4NA 3MDEA 5GJWE 1X8ZA 2RF7A 2PO4A 4KCFA 1XFWA 2E0AA 3MMOA 3N0RA 2BU7A 4V25A 2WBIA 4AKIA 2YYIA 3D2RA 4N5FA 1JM6A 5M4MA 2R0MA 3CRLA 3FO3A 1FS9A 1RJ4A 4IRNA 1XFUA 4L3ZA 1Y8OA 4P79A 5J6AA 2FONA 1X91A 2YYJA 1EGEA 4XVXA 2F6LA 4LQQB 2Q8HA 3UU9A 2GBBA 1IVHA 2YYGA 2EBFX 2JIFA 1U8VA 2XQRB 2OT4A 3SWOA 5BRMA 1Y0VA 2A1TA 3PFDA 2AO2A 3BNFA 2RDZA
chains in the Genus database with same CATH topology
1JQIA 3R7KA 2C0UA 2J7AA 2ZO5A 2YYMA 4G5EA 3TORA 3SF6A 3FCJA 2D29A 1RX0A 1W07A 4O5MA 3EOMA 4ZYJA 4L38A 3AFFA 3P4TA 3M9VA 4L3XA 3OWMA 1GU6A 5K3HA 2YYLA 2JBTA 4Q17A 3D6BA 4U83A 4KTOA 2IX6A 2Z1QA 5K3JA 3UBRA 2E81A 3BNGA 2UXWA 2RFQA 1T9GA 3AFEA 3SCEA 3D9EA 3OIBA 3GM6A 3S7WA 1EGDA 2JBSA 5K3GA 1QDBA 4Q4UA 3LG1A 1FS8A 4Q1OA 3TTBA 3D9FA 2CX9A 2PG0A 2VR0A 2DDHA 3BNJA 2JBRA 3HWCA 2R0NA 4NXLA 4P13A 1WS9A 4L3YA 3D9DA 3SXQA 3MPIA 3X0XA 4Q0TA 1SIQA 1FS7A 3MKHA 1BUCA 3OWAA 4L1FA 1OAHA 4DOYA 2YYKA 2DVLA 4ZXVA 2EBAA 3B96A 3EONA 4OO2A 1EGCA 3D9GA 2VIGA 3NF4A 2REHA 3MXLA 1IS2A 3MPJA 2ZAFA 3GNCA 4Q5BA 4IV6A 4WJYA 4M9AA 1R2JA 3D1IA 2IX5A 4RM7A 3F29A 4W9UA 4X28A 1SIRA 2OR0A 3RKHA 2E80A 4HR3A 4JEKA 3GQTA 4X28C 3BNHA 3X0YA 1UDYA 5K3IA 3L1TA 3MDDA 1UKWA 3II9A 3LGQA 4Q5CA 2C12A 3MDEA 2RF7A 4KCFA 3MMOA 2WBIA 2YYIA 4N5FA 2R0MA 3FO3A 4L3ZA 1FS9A 4IRNA 2FONA 2YYJA 1EGEA 4XVXA 3UU9A 1IVHA 2YYGA 2JIFA 1U8VA 2OT4A 3SWOA 2A1TA 3PFDA 3BNFA 2RDZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JQI A;  3R7K A;  2C0U A;  2J7A A;  2ZO5 A;  2YYM A;  4G5E A;  3TOR A;  3SF6 A;  3FCJ A;  2D29 A;  1RX0 A;  1W07 A;  4O5M A;  3EOM A;  4ZYJ A;  4L38 A;  3AFF A;  3P4T A;  3M9V A;  4L3X A;  3OWM A;  1GU6 A;  5K3H A;  2YYL A;  2JBT A;  4Q17 A;  3D6B A;  4U83 A;  4KTO A;  2IX6 A;  2Z1Q A;  5K3J A;  3UBR A;  2E81 A;  3BNG A;  2UXW A;  2RFQ A;  1T9G A;  3AFE A;  3SCE A;  3D9E A;  3OIB A;  3GM6 A;  3S7W A;  1EGD A;  2JBS A;  5K3G A;  1QDB A;  4Q4U A;  3LG1 A;  1FS8 A;  4Q1O A;  3TTB A;  3D9F A;  2CX9 A;  2PG0 A;  2VR0 A;  2DDH A;  3BNJ A;  2JBR A;  3HWC A;  2R0N A;  4NXL A;  4P13 A;  1WS9 A;  4L3Y A;  3D9D A;  3SXQ A;  3MPI A;  3X0X A;  4Q0T A;  1SIQ A;  1FS7 A;  3MKH A;  1BUC A;  3OWA A;  4L1F A;  1OAH A;  4DOY A;  2YYK A;  2DVL A;  4ZXV A;  2EBA A;  3B96 A;  3EON A;  4OO2 A;  1EGC A;  3D9G A;  2VIG A;  3NF4 A;  2REH A;  3MXL A;  1IS2 A;  3MPJ A;  2ZAF A;  3GNC A;  4Q5B A;  4IV6 A;  4WJY A;  4M9A A;  1R2J A;  3D1I A;  2IX5 A;  4RM7 A;  3F29 A;  4W9U A;  4X28 A;  1SIR A;  2OR0 A;  3RKH A;  2E80 A;  4HR3 A;  4JEK A;  3GQT A;  4X28 C;  3BNH A;  3X0Y A;  1UDY A;  5K3I A;  3L1T A;  3MDD A;  1UKW A;  3II9 A;  3LGQ A;  4Q5C A;  2C12 A;  3MDE A;  2RF7 A;  4KCF A;  3MMO A;  2WBI A;  2YYI A;  4N5F A;  2R0M A;  3FO3 A;  4L3Z A;  1FS9 A;  4IRN A;  2FON A;  2YYJ A;  1EGE A;  4XVX A;  3UU9 A;  1IVH A;  2YYG A;  2JIF A;  1U8V A;  2OT4 A;  3SWO A;  2A1T A;  3PFD A;  3BNF A;  2RDZ A; 
#chains in the Genus database with same CATH topology
 1JQI A;  1XFY A;  2OEX A;  4DZY A;  3R7K A;  1XFV A;  4E00 A;  5M4K A;  5B5W A;  2C0U A;  2ZDX A;  2J7A A;  2ZO5 A;  4HKS A;  3VKG A;  2YYM A;  4G5E A;  3TOR A;  3SF6 A;  4MPE A;  4E01 A;  1Y8N A;  3FCJ A;  1XFX A;  2D29 A;  1RX0 A;  2FP1 A;  1W07 A;  4O5M A;  3EOM A;  4ZYJ A;  2ZDY A;  3AFF A;  4H7Q A;  4L38 A;  2Q8F A;  3P4T A;  2OJQ A;  3M9V A;  2PNR A;  4L3X A;  2VF1 A;  3OWM A;  1GU6 A;  4MP7 A;  3TZ5 A;  1GJV A;  4FF1 A;  5K3H A;  4AKH A;  5EZ3 A;  2YYL A;  2EBH X;  1R3B A;  2ZKJ A;  4KS9 A;  3DJL A;  2JBT A;  3Q22 A;  4Q17 A;  3D6B A;  4U83 A;  4KTO A;  3CRK A;  3Q23 A;  2IX6 A;  2CJ4 A;  2Z1Q A;  5K3J A;  3UBR A;  2E81 A;  3BNG A;  2UXW A;  2RFQ A;  1T9G A;  3AFE A;  1RP3 A;  3SCE A;  4FF4 A;  3D9E A;  3X29 A;  4FZ4 A;  4KSA A;  3OIB A;  2CJ5 A;  3GM6 A;  3S7W A;  1EGD A;  2R05 A;  2JBS A;  4QIC A;  5K3G A;  2YGW A;  1QDB A;  2OEV A;  4Q4U A;  3LG1 A;  1SK6 A;  1FS8 A;  1LVC A;  2QR4 A;  4Q1O A;  3D9F A;  3TTB A;  3C3L A;  1XFZ A;  3VKH A;  3U33 A;  1GKZ A;  2CX9 A;  2PG0 A;  2VR0 A;  2CJ6 A;  3Q0A A;  2DDH A;  4JIZ A;  5B5V A;  3BNJ A;  2JBR A;  1RJ1 A;  2R0N A;  3HWC A;  4NXL A;  4P13 A;  1WS9 A;  4L3Y A;  3D9D A;  1S26 A;  3SXQ A;  2HJN A;  4KSF A;  3MPI A;  3X0X A;  2CJ7 A;  2FP2 A;  5M4P A;  4Q0T A;  5J71 A;  4FF3 A;  1SIQ A;  1X90 A;  2LFW A;  4E02 A;  1FS7 A;  3MKH A;  1BUC A;  3OWA A;  5GJV E;  4L1F A;  1OAH A;  4DOY A;  3TZ4 A;  2YYK A;  1K8T A;  1K90 A;  4F0X A;  2DVL A;  4MP2 A;  1GKX A;  4ZXV A;  2EBA A;  3B96 A;  3EON A;  1Y8P A;  2BU8 A;  2XS1 A;  3KML A;  1EGC A;  4OO2 A;  3D9G A;  2VIG A;  3NF4 A;  4FF2 A;  2REH A;  2Q8G A;  3MXL A;  3TZ2 A;  2Q8I A;  4H81 A;  1IS2 A;  3MPJ A;  2ZAF A;  2BTZ A;  1K93 A;  3C2P A;  3C46 A;  3GNC A;  4Q5B A;  4IV6 A;  2AZE A;  4WJY A;  2R02 A;  4M9A A;  1R2J A;  3D1I A;  4AKG A;  4G97 A;  2IX5 A;  4RM7 A;  3F29 A;  4W9U A;  2CJ8 A;  2EC5 A;  2R03 A;  4X28 A;  1SIR A;  2XS8 A;  4HKR A;  1PI1 A;  2OR0 A;  1SC5 A;  2BU2 A;  3CE2 A;  4J1V A;  4MPC A;  1PK0 A;  3RKH A;  3VAD A;  4H85 A;  4V26 A;  2E80 A;  4LQS B;  4HR3 A;  4JEK A;  3Q24 A;  3GQT A;  5BRK A;  4AI6 A;  4X28 C;  3BNH A;  4MPN A;  2BU6 A;  3X0Y A;  1UDY A;  5K3I A;  3L1T A;  1XG2 B;  3MDD A;  4JIO A;  1UKW A;  3TZ0 A;  3II9 A;  5B6B A;  3LGQ A;  4Q5C A;  2C12 A;  2BU5 A;  5M4N A;  3MDE A;  5GJW E;  1X8Z A;  2RF7 A;  2PO4 A;  4KCF A;  1XFW A;  2E0A A;  3MMO A;  3N0R A;  2BU7 A;  4V25 A;  2WBI A;  4AKI A;  2YYI A;  3D2R A;  4N5F A;  1JM6 A;  5M4M A;  2R0M A;  3CRL A;  3FO3 A;  1FS9 A;  1RJ4 A;  4IRN A;  1XFU A;  4L3Z A;  1Y8O A;  4P79 A;  5J6A A;  2FON A;  1X91 A;  2YYJ A;  1EGE A;  4XVX A;  2F6L A;  4LQQ B;  2Q8H A;  3UU9 A;  2GBB A;  1IVH A;  2YYG A;  2EBF X;  2JIF A;  1U8V A;  2XQR B;  2OT4 A;  3SWO A;  5BRM A;  1Y0V A;  2A1T A;  3PFD A;  2AO2 A;  3BNF A;  2RDZ A; 
#chains in the Genus database with same CATH homology
 1JQI A;  3R7K A;  2C0U A;  2J7A A;  2ZO5 A;  2YYM A;  4G5E A;  3TOR A;  3SF6 A;  3FCJ A;  2D29 A;  1RX0 A;  1W07 A;  4O5M A;  3EOM A;  4ZYJ A;  4L38 A;  3AFF A;  3P4T A;  3M9V A;  4L3X A;  3OWM A;  1GU6 A;  5K3H A;  2YYL A;  2JBT A;  4Q17 A;  3D6B A;  4U83 A;  4KTO A;  2IX6 A;  2Z1Q A;  5K3J A;  3UBR A;  2E81 A;  3BNG A;  2UXW A;  2RFQ A;  1T9G A;  3AFE A;  3SCE A;  3D9E A;  3OIB A;  3GM6 A;  3S7W A;  1EGD A;  2JBS A;  5K3G A;  1QDB A;  4Q4U A;  3LG1 A;  1FS8 A;  4Q1O A;  3TTB A;  3D9F A;  2CX9 A;  2PG0 A;  2VR0 A;  2DDH A;  3BNJ A;  2JBR A;  3HWC A;  2R0N A;  4NXL A;  4P13 A;  1WS9 A;  4L3Y A;  3D9D A;  3SXQ A;  3MPI A;  3X0X A;  4Q0T A;  1SIQ A;  1FS7 A;  3MKH A;  1BUC A;  3OWA A;  4L1F A;  1OAH A;  4DOY A;  2YYK A;  2DVL A;  4ZXV A;  2EBA A;  3B96 A;  3EON A;  4OO2 A;  1EGC A;  3D9G A;  2VIG A;  3NF4 A;  2REH A;  3MXL A;  1IS2 A;  3MPJ A;  2ZAF A;  3GNC A;  4Q5B A;  4IV6 A;  4WJY A;  4M9A A;  1R2J A;  3D1I A;  2IX5 A;  4RM7 A;  3F29 A;  4W9U A;  4X28 A;  1SIR A;  2OR0 A;  3RKH A;  2E80 A;  4HR3 A;  4JEK A;  3GQT A;  4X28 C;  3BNH A;  3X0Y A;  1UDY A;  5K3I A;  3L1T A;  3MDD A;  1UKW A;  3II9 A;  3LGQ A;  4Q5C A;  2C12 A;  3MDE A;  2RF7 A;  4KCF A;  3MMO A;  2WBI A;  2YYI A;  4N5F A;  2R0M A;  3FO3 A;  4L3Z A;  1FS9 A;  4IRN A;  2FON A;  2YYJ A;  1EGE A;  4XVX A;  3UU9 A;  1IVH A;  2YYG A;  2JIF A;  1U8V A;  2OT4 A;  3SWO A;  2A1T A;  3PFD A;  3BNF A;  2RDZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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