1SIQA

The crystal structure and mechanism of human glutaryl-coa dehydrogenase
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
390
structure length
390
Chain Sequence
EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Glutaryl-CoA dehydrogenase
publication title Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions
pubmed doi rcsb
total genus 151
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2004-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1siqA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1siqA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1siqA02
4M9AA 4ZXVA 3D9FA 3LG1A 2WBIA 1FS7A 1EGEA 4DOYA 4O5MA 3BNGA 3RKHA 2IX5A 1IS2A 2ZAFA 3SF6A 2UXWA 3MPIA 4L3YA 4X28C 2J7AA 2OR0A 5K3JA 4G5EA 5K3IA 3D9DA 4N5FA 4Q5BA 2JBTA 3MDDA 2YYGA 4OO2A 2JBRA 4W9UA 3OIBA 3BNFA 4NXLA 4L38A 2IX6A 2R0MA 1U8VA 2YYIA 1QDBA 4Q1OA 2CX9A 2VIGA 1R2JA 2OT4A 1BUCA 2REHA 4L1FA 1T9GA 2JIFA 1SIRA 3TTBA 2E81A 3P4TA 3MPJA 3SWOA 1UKWA 3SCEA 3S7WA 1JQIA 3AFFA 3D1IA 3X0YA 4Q5CA 3MKHA 5K3HA 4RM7A 2FONA 4Q4UA 3MXLA 2D29A 3II9A 3GNCA 1WS9A 2A1TA 1W07A 2YYMA 3UU9A 2RF7A 1UDYA 2Z1QA 4IV6A 4IRNA 2YYLA 4P13A 1GU6A 2EBAA 3NF4A 4KTOA 4Q0TA 4ZYJA 2ZO5A 4XVXA 3LGQA 3SXQA 3UBRA 2C12A 1EGDA 3D9EA 1SIQA 3M9VA 3D9GA 3OWAA 3PFDA 3GQTA 4HR3A 2DDHA 3BNHA 3MMOA 3X0XA 3EONA 2RFQA 3BNJA 5K3GA 3R7KA 2YYJA 3TORA 3F29A 4Q17A 4KCFA 1FS9A 3EOMA 4L3ZA 4WJYA 2RDZA 1EGCA 4L3XA 3AFEA 2YYKA 1RX0A 3MDEA 4X28A 3OWMA 3GM6A 2PG0A 1OAHA 3D6BA 2C0UA 4JEKA 2JBSA 3FO3A 2VR0A 3L1TA 3B96A 2E80A 2DVLA 3HWCA 3FCJA 4U83A 1FS8A 2R0NA 1IVHA
chains in the Genus database with same CATH superfamily
2YGWA 4M9AA 3N0RA 1GKZA 2R02A 4ZXVA 3D9FA 4LQSB 4F0XA 5EZ3A 3LG1A 2WBIA 2ZDYA 1FS7A 1Y8PA 2BU5A 1EGEA 4DOYA 4V25A 4O5MA 2EC5A 3Q24A 4J1VA 4H7QA 5M4MA 3BNGA 3CRKA 2AZEA 4P79A 4FF1A 5BRKA 4KS9A 3RKHA 2IX5A 4E01A 1IS2A 1K93A 2CJ4A 2OEVA 3C46A 2ZAFA 2BU6A 3SF6A 2EBHX 2XQRB 2BU7A 3VADA 2UXWA 3MPIA 1XFVA 4X28C 1K8TA 2OR0A 2J7AA 5K3JA 2BTZA 2LFWA 1GKXA 3KMLA 4E02A 4FF2A 4G5EA 5K3IA 5J71A 3D9DA 4N5FA 1XFZA 4Q5BA 3Q0AA 4H81A 2CJ6A 2JBTA 1K90A 3MDDA 2YYGA 1XFWA 3CRLA 1SC5A 2JBRA 4OO2A 5GJVE 2XS1A 4W9UA 4FF4A 5BRMA 3OIBA 3BNFA 4NXLA 4L38A 4H85A 4AKGA 2IX6A 2R0MA 1U8VA 1Y8NA 4KSAA 3C2PA 2YYIA 1QDBA 2CJ5A 4Q1OA 2CX9A 2VIGA 1R2JA 2OT4A 1BUCA 2REHA 1LVCA 4L1FA 4AKHA 3DJLA 1T9GA 2JIFA 1SIRA 3TTBA 2E81A 3P4TA 2CJ8A 3MPJA 3SWOA 2BU8A 1UKWA 3SCEA 3S7WA 1JQIA 3AFFA 3D1IA 1RP3A 4QICA 2CJ7A 3X0YA 2EBFX 2R03A 4Q5CA 3MKHA 5K3HA 2PNRA 5M4NA 4RM7A 2FONA 1PI1A 2FP2A 2ZKJA 4Q4UA 4MPEA 3MXLA 2D29A 3II9A 3GNCA 1WS9A 2A1TA 1W07A 2YYMA 3CE2A 2RF7A 3UU9A 1UDYA 2Z1QA 4IV6A 4MP2A 4IRNA 2YYLA 4KSFA 4P13A 2Q8GA 1GU6A 2EBAA 2OJQA 3NF4A 4KTOA 4Q0TA 4ZYJA 1XG2B 2ZO5A 4G97A 4XVXA 3D2RA 1SK6A 3LGQA 4DZYA 3Q22A 2VF1A 3SXQA 3UBRA 2C12A 1EGDA 3D9EA 1SIQA 3TZ5A 3VKHA 3M9VA 3D9GA 3X29A 3OWAA 2XS8A 1XFYA 3PFDA 2BU2A 4MP7A 3GQTA 4HR3A 4HKRA 2DDHA 2GBBA 3BNHA 3MMOA 4V26A 3X0XA 4E00A 4L3YA 4JIZA 3EONA 1X90A 1XFXA 2PO4A 5J6AA 2RFQA 1Y8OA 4AI6A 3BNJA 5GJWE 5K3GA 3R7KA 2YYJA 3TORA 1RJ4A 3TZ4A 2E0AA 3F29A 4AKIA 2HJNA 4Q17A 4MPNA 5M4PA 4KCFA 1FS9A 3EOMA 4L3ZA 4WJYA 3TZ2A 2RDZA 3C3LA 1EGCA 4L3XA 4LQQB 3AFEA 1GJVA 2YYKA 4MPCA 5B6BA 3TZ0A 1PK0A 2F6LA 2QR4A 1R3BA 1RX0A 2ZDXA 4FZ4A 3MDEA 4X28A 3OWMA 4JIOA 3GM6A 2PG0A 1OAHA 1JM6A 2Q8IA 4FF3A 1X8ZA 3VKGA 2Q8HA 3D6BA 2C0UA 4JEKA 2JBSA 1RJ1A 1S26A 1XFUA 2FP1A 3FO3A 2VR0A 3L1TA 3Q23A 3B96A 5B5WA 2OEXA 1Y0VA 2E80A 5B5VA 4HKSA 2R05A 2Q8FA 2DVLA 3HWCA 5M4KA 3U33A 3FCJA 4U83A 1FS8A 2R0NA 1X91A 2AO2A 1IVHA
chains in the Genus database with same CATH topology
4M9AA 4ZXVA 3D9FA 3LG1A 2WBIA 1FS7A 1EGEA 4DOYA 4O5MA 3BNGA 3RKHA 2IX5A 1IS2A 2ZAFA 3SF6A 2UXWA 3MPIA 4L3YA 4X28C 2J7AA 2OR0A 5K3JA 4G5EA 5K3IA 3D9DA 4N5FA 4Q5BA 2JBTA 3MDDA 2YYGA 4OO2A 2JBRA 4W9UA 3OIBA 3BNFA 4NXLA 4L38A 2IX6A 2R0MA 1U8VA 2YYIA 1QDBA 4Q1OA 2CX9A 2VIGA 1R2JA 2OT4A 1BUCA 2REHA 4L1FA 1T9GA 2JIFA 1SIRA 3TTBA 2E81A 3P4TA 3MPJA 3SWOA 1UKWA 3SCEA 3S7WA 1JQIA 3AFFA 3D1IA 3X0YA 4Q5CA 3MKHA 5K3HA 4RM7A 2FONA 4Q4UA 3MXLA 2D29A 3II9A 3GNCA 1WS9A 2A1TA 1W07A 2YYMA 3UU9A 2RF7A 1UDYA 2Z1QA 4IV6A 4IRNA 2YYLA 4P13A 1GU6A 2EBAA 3NF4A 4KTOA 4Q0TA 4ZYJA 2ZO5A 4XVXA 3LGQA 3SXQA 3UBRA 2C12A 1EGDA 3D9EA 1SIQA 3M9VA 3D9GA 3OWAA 3PFDA 3GQTA 4HR3A 2DDHA 3BNHA 3MMOA 3X0XA 3EONA 2RFQA 3BNJA 5K3GA 3R7KA 2YYJA 3TORA 3F29A 4Q17A 4KCFA 1FS9A 3EOMA 4L3ZA 4WJYA 2RDZA 1EGCA 4L3XA 3AFEA 2YYKA 1RX0A 3MDEA 4X28A 3OWMA 3GM6A 2PG0A 1OAHA 3D6BA 2C0UA 4JEKA 2JBSA 3FO3A 2VR0A 3L1TA 3B96A 2E80A 2DVLA 3HWCA 3FCJA 4U83A 1FS8A 2R0NA 1IVHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M9A A;  4ZXV A;  3D9F A;  3LG1 A;  2WBI A;  1FS7 A;  1EGE A;  4DOY A;  4O5M A;  3BNG A;  3RKH A;  2IX5 A;  1IS2 A;  2ZAF A;  3SF6 A;  2UXW A;  3MPI A;  4L3Y A;  4X28 C;  2J7A A;  2OR0 A;  5K3J A;  4G5E A;  5K3I A;  3D9D A;  4N5F A;  4Q5B A;  2JBT A;  3MDD A;  2YYG A;  4OO2 A;  2JBR A;  4W9U A;  3OIB A;  3BNF A;  4NXL A;  4L38 A;  2IX6 A;  2R0M A;  1U8V A;  2YYI A;  1QDB A;  4Q1O A;  2CX9 A;  2VIG A;  1R2J A;  2OT4 A;  1BUC A;  2REH A;  4L1F A;  1T9G A;  2JIF A;  1SIR A;  3TTB A;  2E81 A;  3P4T A;  3MPJ A;  3SWO A;  1UKW A;  3SCE A;  3S7W A;  1JQI A;  3AFF A;  3D1I A;  3X0Y A;  4Q5C A;  3MKH A;  5K3H A;  4RM7 A;  2FON A;  4Q4U A;  3MXL A;  2D29 A;  3II9 A;  3GNC A;  1WS9 A;  2A1T A;  1W07 A;  2YYM A;  3UU9 A;  2RF7 A;  1UDY A;  2Z1Q A;  4IV6 A;  4IRN A;  2YYL A;  4P13 A;  1GU6 A;  2EBA A;  3NF4 A;  4KTO A;  4Q0T A;  4ZYJ A;  2ZO5 A;  4XVX A;  3LGQ A;  3SXQ A;  3UBR A;  2C12 A;  1EGD A;  3D9E A;  1SIQ A;  3M9V A;  3D9G A;  3OWA A;  3PFD A;  3GQT A;  4HR3 A;  2DDH A;  3BNH A;  3MMO A;  3X0X A;  3EON A;  2RFQ A;  3BNJ A;  5K3G A;  3R7K A;  2YYJ A;  3TOR A;  3F29 A;  4Q17 A;  4KCF A;  1FS9 A;  3EOM A;  4L3Z A;  4WJY A;  2RDZ A;  1EGC A;  4L3X A;  3AFE A;  2YYK A;  1RX0 A;  3MDE A;  4X28 A;  3OWM A;  3GM6 A;  2PG0 A;  1OAH A;  3D6B A;  2C0U A;  4JEK A;  2JBS A;  3FO3 A;  2VR0 A;  3L1T A;  3B96 A;  2E80 A;  2DVL A;  3HWC A;  3FCJ A;  4U83 A;  1FS8 A;  2R0N A;  1IVH A; 
#chains in the Genus database with same CATH topology
 2YGW A;  4M9A A;  3N0R A;  1GKZ A;  2R02 A;  4ZXV A;  3D9F A;  4LQS B;  4F0X A;  5EZ3 A;  3LG1 A;  2WBI A;  2ZDY A;  1FS7 A;  1Y8P A;  2BU5 A;  1EGE A;  4DOY A;  4V25 A;  4O5M A;  2EC5 A;  3Q24 A;  4J1V A;  4H7Q A;  5M4M A;  3BNG A;  3CRK A;  2AZE A;  4P79 A;  4FF1 A;  5BRK A;  4KS9 A;  3RKH A;  2IX5 A;  4E01 A;  1IS2 A;  1K93 A;  2CJ4 A;  2OEV A;  3C46 A;  2ZAF A;  2BU6 A;  3SF6 A;  2EBH X;  2XQR B;  2BU7 A;  3VAD A;  2UXW A;  3MPI A;  1XFV A;  4X28 C;  1K8T A;  2OR0 A;  2J7A A;  5K3J A;  2BTZ A;  2LFW A;  1GKX A;  3KML A;  4E02 A;  4FF2 A;  4G5E A;  5K3I A;  5J71 A;  3D9D A;  4N5F A;  1XFZ A;  4Q5B A;  3Q0A A;  4H81 A;  2CJ6 A;  2JBT A;  1K90 A;  3MDD A;  2YYG A;  1XFW A;  3CRL A;  1SC5 A;  2JBR A;  4OO2 A;  5GJV E;  2XS1 A;  4W9U A;  4FF4 A;  5BRM A;  3OIB A;  3BNF A;  4NXL A;  4L38 A;  4H85 A;  4AKG A;  2IX6 A;  2R0M A;  1U8V A;  1Y8N A;  4KSA A;  3C2P A;  2YYI A;  1QDB A;  2CJ5 A;  4Q1O A;  2CX9 A;  2VIG A;  1R2J A;  2OT4 A;  1BUC A;  2REH A;  1LVC A;  4L1F A;  4AKH A;  3DJL A;  1T9G A;  2JIF A;  1SIR A;  3TTB A;  2E81 A;  3P4T A;  2CJ8 A;  3MPJ A;  3SWO A;  2BU8 A;  1UKW A;  3SCE A;  3S7W A;  1JQI A;  3AFF A;  3D1I A;  1RP3 A;  4QIC A;  2CJ7 A;  3X0Y A;  2EBF X;  2R03 A;  4Q5C A;  3MKH A;  5K3H A;  2PNR A;  5M4N A;  4RM7 A;  2FON A;  1PI1 A;  2FP2 A;  2ZKJ A;  4Q4U A;  4MPE A;  3MXL A;  2D29 A;  3II9 A;  3GNC A;  1WS9 A;  2A1T A;  1W07 A;  2YYM A;  3CE2 A;  2RF7 A;  3UU9 A;  1UDY A;  2Z1Q A;  4IV6 A;  4MP2 A;  4IRN A;  2YYL A;  4KSF A;  4P13 A;  2Q8G A;  1GU6 A;  2EBA A;  2OJQ A;  3NF4 A;  4KTO A;  4Q0T A;  4ZYJ A;  1XG2 B;  2ZO5 A;  4G97 A;  4XVX A;  3D2R A;  1SK6 A;  3LGQ A;  4DZY A;  3Q22 A;  2VF1 A;  3SXQ A;  3UBR A;  2C12 A;  1EGD A;  3D9E A;  1SIQ A;  3TZ5 A;  3VKH A;  3M9V A;  3D9G A;  3X29 A;  3OWA A;  2XS8 A;  1XFY A;  3PFD A;  2BU2 A;  4MP7 A;  3GQT A;  4HR3 A;  4HKR A;  2DDH A;  2GBB A;  3BNH A;  3MMO A;  4V26 A;  3X0X A;  4E00 A;  4L3Y A;  4JIZ A;  3EON A;  1X90 A;  1XFX A;  2PO4 A;  5J6A A;  2RFQ A;  1Y8O A;  4AI6 A;  3BNJ A;  5GJW E;  5K3G A;  3R7K A;  2YYJ A;  3TOR A;  1RJ4 A;  3TZ4 A;  2E0A A;  3F29 A;  4AKI A;  2HJN A;  4Q17 A;  4MPN A;  5M4P A;  4KCF A;  1FS9 A;  3EOM A;  4L3Z A;  4WJY A;  3TZ2 A;  2RDZ A;  3C3L A;  1EGC A;  4L3X A;  4LQQ B;  3AFE A;  1GJV A;  2YYK A;  4MPC A;  5B6B A;  3TZ0 A;  1PK0 A;  2F6L A;  2QR4 A;  1R3B A;  1RX0 A;  2ZDX A;  4FZ4 A;  3MDE A;  4X28 A;  3OWM A;  4JIO A;  3GM6 A;  2PG0 A;  1OAH A;  1JM6 A;  2Q8I A;  4FF3 A;  1X8Z A;  3VKG A;  2Q8H A;  3D6B A;  2C0U A;  4JEK A;  2JBS A;  1RJ1 A;  1S26 A;  1XFU A;  2FP1 A;  3FO3 A;  2VR0 A;  3L1T A;  3Q23 A;  3B96 A;  5B5W A;  2OEX A;  1Y0V A;  2E80 A;  5B5V A;  4HKS A;  2R05 A;  2Q8F A;  2DVL A;  3HWC A;  5M4K A;  3U33 A;  3FCJ A;  4U83 A;  1FS8 A;  2R0N A;  1X91 A;  2AO2 A;  1IVH A; 
#chains in the Genus database with same CATH homology
 4M9A A;  4ZXV A;  3D9F A;  3LG1 A;  2WBI A;  1FS7 A;  1EGE A;  4DOY A;  4O5M A;  3BNG A;  3RKH A;  2IX5 A;  1IS2 A;  2ZAF A;  3SF6 A;  2UXW A;  3MPI A;  4L3Y A;  4X28 C;  2J7A A;  2OR0 A;  5K3J A;  4G5E A;  5K3I A;  3D9D A;  4N5F A;  4Q5B A;  2JBT A;  3MDD A;  2YYG A;  4OO2 A;  2JBR A;  4W9U A;  3OIB A;  3BNF A;  4NXL A;  4L38 A;  2IX6 A;  2R0M A;  1U8V A;  2YYI A;  1QDB A;  4Q1O A;  2CX9 A;  2VIG A;  1R2J A;  2OT4 A;  1BUC A;  2REH A;  4L1F A;  1T9G A;  2JIF A;  1SIR A;  3TTB A;  2E81 A;  3P4T A;  3MPJ A;  3SWO A;  1UKW A;  3SCE A;  3S7W A;  1JQI A;  3AFF A;  3D1I A;  3X0Y A;  4Q5C A;  3MKH A;  5K3H A;  4RM7 A;  2FON A;  4Q4U A;  3MXL A;  2D29 A;  3II9 A;  3GNC A;  1WS9 A;  2A1T A;  1W07 A;  2YYM A;  3UU9 A;  2RF7 A;  1UDY A;  2Z1Q A;  4IV6 A;  4IRN A;  2YYL A;  4P13 A;  1GU6 A;  2EBA A;  3NF4 A;  4KTO A;  4Q0T A;  4ZYJ A;  2ZO5 A;  4XVX A;  3LGQ A;  3SXQ A;  3UBR A;  2C12 A;  1EGD A;  3D9E A;  1SIQ A;  3M9V A;  3D9G A;  3OWA A;  3PFD A;  3GQT A;  4HR3 A;  2DDH A;  3BNH A;  3MMO A;  3X0X A;  3EON A;  2RFQ A;  3BNJ A;  5K3G A;  3R7K A;  2YYJ A;  3TOR A;  3F29 A;  4Q17 A;  4KCF A;  1FS9 A;  3EOM A;  4L3Z A;  4WJY A;  2RDZ A;  1EGC A;  4L3X A;  3AFE A;  2YYK A;  1RX0 A;  3MDE A;  4X28 A;  3OWM A;  3GM6 A;  2PG0 A;  1OAH A;  3D6B A;  2C0U A;  4JEK A;  2JBS A;  3FO3 A;  2VR0 A;  3L1T A;  3B96 A;  2E80 A;  2DVL A;  3HWC A;  3FCJ A;  4U83 A;  1FS8 A;  2R0N A;  1IVH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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