1SIQA

The crystal structure and mechanism of human glutaryl-coa dehydrogenase
Total Genus 151
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
390
structure length
390
Chain Sequence
b'EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Glutaryl-CoA dehydrogenase
publication title Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions
pubmed doi rcsb
molecule tags Oxidoreductase
total genus 151
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2004-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1siqA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1siqA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1siqA02
1OAHA 3UU9A 2YYLA 4IRNA 4L3YA 2OR0A 2E80A 1U8VA 4Q5CA 1IS2A 2A1TA 4N5FA 3FO3A 4HR3A 3SCEA 4JEKA 1EGCA 1UKWA 4ZYJA 1SIQA 1JQIA 3X0YA 2ZAFA 4Q17A 3HWCA 1QDBA 3EONA 3D9GA 4M9AA 2E81A 4W9UA 3MDDA 4X28A 4KTOA 2R0NA 3B96A 3MKHA 2RFQA 3EOMA 4X28C 3MMOA 3MPJA 1FS7A 1BUCA 3BNHA 2JBSA 1UDYA 4Q4UA 5K3HA 3MPIA 3OIBA 2EBAA 2CX9A 3F29A 1T9GA 3R7KA 1GU6A 4O5MA 2J7AA 3LGQA 4KCFA 3NF4A 1R2JA 4XVXA 1FS9A 3BNGA 4OO2A 2DDHA 5K3IA 2RDZA 3D1IA 1EGDA 2R0MA 4Q1OA 3TTBA 3AFFA 3AFEA 2IX5A 3GM6A 4P13A 3OWAA 2VR0A 2VIGA 3M9VA 2IX6A 3UBRA 4IV6A 3LG1A 2WBIA 2YYKA 4Q0TA 4Q5BA 2YYJA 2PG0A 3SWOA 4ZXVA 2UXWA 3GNCA 1EGEA 3MXLA 3TORA 2REHA 3D6BA 4WJYA 4L1FA 5K3GA 2D29A 2C0UA 3PFDA 4NXLA 4L3ZA 3S7WA 2JBTA 4DOYA 3X0XA 1FS8A 3OWMA 2JBRA 3L1TA 2YYMA 4U83A 3RKHA 3FCJA 1IVHA 3D9FA 2ZO5A 4G5EA 4RM7A 1RX0A 3D9DA 3MDEA 3P4TA 2YYIA 3GQTA 3II9A 4L3XA 2DVLA 1W07A 2C12A 5K3JA 2JIFA 3SF6A 3BNFA 2OT4A 1WS9A 4L38A 2FONA 1SIRA 3SXQA 2RF7A 3BNJA 3D9EA 2Z1QA 2YYGA
chains in the Genus database with same CATH superfamily
2ZDXA 4E02A 1OAHA 3UU9A 3TZ5A 2YYLA 4FZ4A 4IRNA 4L3YA 3VADA 2OR0A 4MPEA 2EBHX 3Q23A 2E80A 2OEVA 1U8VA 3VKHA 4Q5CA 1IS2A 2A1TA 4N5FA 2R05A 4HR3A 3FO3A 3SCEA 4F0XA 4JEKA 2PNRA 4MPCA 1EGCA 1UKWA 4ZYJA 1JM6A 4HKSA 1K90A 4FF2A 1SIQA 1JQIA 3X0YA 2CJ8A 4V26A 2ZAFA 4Q17A 4E00A 5M4PA 3HWCA 4KS9A 1XFWA 1PI1A 1QDBA 3EONA 3D9GA 4M9AA 4J1VA 2Q8IA 3C2PA 2CJ4A 2E81A 4W9UA 1Y0VA 1S26A 3MDDA 4X28A 1XFYA 4AKIA 4KTOA 2EC5A 2OJQA 2Q8HA 2R0NA 3B96A 1Y8OA 3MKHA 2AO2A 4V25A 1XFXA 2RFQA 3EOMA 1SC5A 2OEXA 4X28C 2ZKJA 3MMOA 2VF1A 3TZ4A 3MPJA 2GBBA 1R3BA 1FS7A 1Y8NA 1BUCA 3BNHA 3U33A 2JBSA 2R03A 1UDYA 4Q4UA 1GKXA 3Q22A 5K3HA 1SK6A 3MPIA 3OIBA 2E0AA 2LFWA 3C46A 4H81A 2EBAA 2Q8GA 5B6BA 4MP2A 1RJ4A 2CX9A 2BU2A 3F29A 1T9GA 3R7KA 1GU6A 4O5MA 2J7AA 5B5VA 5BRKA 5EZ3A 2EBFX 3LGQA 1XFUA 4KCFA 3NF4A 4JIOA 1R2JA 4AKGA 4XVXA 1FS9A 2XS1A 3BNGA 2HJNA 2AZEA 2DDHA 5K3IA 2RDZA 4OO2A 2BU6A 3VKGA 3DJLA 2BTZA 3D1IA 3CE2A 1EGDA 2R0MA 4Q1OA 3TTBA 3AFFA 3AFEA 2IX5A 2CJ6A 3D2RA 4P13A 3OWAA 3GM6A 1RP3A 1XFVA 2VR0A 4HKRA 2VIGA 3M9VA 1X91A 2IX6A 1XFZA 1GKZA 2YGWA 3UBRA 3Q0AA 1X90A 4IV6A 1PK0A 2F6LA 3LG1A 4H7QA 4LQQB 2WBIA 1X8ZA 2YYKA 4Q0TA 4Q5BA 4QICA 2CJ7A 2BU8A 2YYJA 2PG0A 5M4NA 3SWOA 4ZXVA 2Q8FA 1Y8PA 2UXWA 3GNCA 1EGEA 2PO4A 4FF4A 3MXLA 4G97A 4H85A 3TORA 2REHA 3D6BA 1GJVA 1K93A 4L1FA 5K3GA 2FP1A 2D29A 4WJYA 2C0UA 3PFDA 4NXLA 3X29A 4L3ZA 3TZ0A 4AI6A 3S7WA 4AKHA 2JBTA 4DOYA 3X0XA 1FS8A 2R02A 3OWMA 2JBRA 3L1TA 2YYMA 4P79A 5GJWE 4U83A 3RKHA 4DZYA 2BU5A 4FF3A 2BU7A 3FCJA 5J6AA 1IVHA 2QR4A 5BRMA 3N0RA 2XS8A 3D9FA 2ZO5A 4G5EA 4RM7A 1RX0A 3D9DA 3MDEA 1RJ1A 4KSAA 3P4TA 5B5WA 1LVCA 3Q24A 2YYIA 4JIZA 3GQTA 3II9A 4LQSB 4L3XA 2DVLA 1W07A 2C12A 5K3JA 2CJ5A 3CRKA 4KSFA 2JIFA 3SF6A 3BNFA 1XG2B 4MP7A 2OT4A 3TZ2A 2ZDYA 5J71A 5M4MA 1WS9A 5GJVE 4L38A 2FONA 1SIRA 3CRLA 3SXQA 4FF1A 2FP2A 2RF7A 3KMLA 3BNJA 3C3LA 2XQRB 4MPNA 4E01A 5M4KA 3D9EA 2Z1QA 2YYGA 1K8TA
chains in the Genus database with same CATH topology
1OAHA 3UU9A 2YYLA 4IRNA 4L3YA 2OR0A 2E80A 1U8VA 4Q5CA 1IS2A 2A1TA 4N5FA 3FO3A 4HR3A 3SCEA 4JEKA 1EGCA 1UKWA 4ZYJA 1SIQA 1JQIA 3X0YA 2ZAFA 4Q17A 3HWCA 1QDBA 3EONA 3D9GA 4M9AA 2E81A 4W9UA 3MDDA 4X28A 4KTOA 2R0NA 3B96A 3MKHA 2RFQA 3EOMA 4X28C 3MMOA 3MPJA 1FS7A 1BUCA 3BNHA 2JBSA 1UDYA 4Q4UA 5K3HA 3MPIA 3OIBA 2EBAA 2CX9A 3F29A 1T9GA 3R7KA 1GU6A 4O5MA 2J7AA 3LGQA 4KCFA 3NF4A 1R2JA 4XVXA 1FS9A 3BNGA 4OO2A 2DDHA 5K3IA 2RDZA 3D1IA 1EGDA 2R0MA 4Q1OA 3TTBA 3AFFA 3AFEA 2IX5A 3GM6A 4P13A 3OWAA 2VR0A 2VIGA 3M9VA 2IX6A 3UBRA 4IV6A 3LG1A 2WBIA 2YYKA 4Q0TA 4Q5BA 2YYJA 2PG0A 3SWOA 4ZXVA 2UXWA 3GNCA 1EGEA 3MXLA 3TORA 2REHA 3D6BA 4WJYA 4L1FA 5K3GA 2D29A 2C0UA 3PFDA 4NXLA 4L3ZA 3S7WA 2JBTA 4DOYA 3X0XA 1FS8A 3OWMA 2JBRA 3L1TA 2YYMA 4U83A 3RKHA 3FCJA 1IVHA 3D9FA 2ZO5A 4G5EA 4RM7A 1RX0A 3D9DA 3MDEA 3P4TA 2YYIA 3GQTA 3II9A 4L3XA 2DVLA 1W07A 2C12A 5K3JA 2JIFA 3SF6A 3BNFA 2OT4A 1WS9A 4L38A 2FONA 1SIRA 3SXQA 2RF7A 3BNJA 3D9EA 2Z1QA 2YYGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OAH A;  3UU9 A;  2YYL A;  4IRN A;  4L3Y A;  2OR0 A;  2E80 A;  1U8V A;  4Q5C A;  1IS2 A;  2A1T A;  4N5F A;  3FO3 A;  4HR3 A;  3SCE A;  4JEK A;  1EGC A;  1UKW A;  4ZYJ A;  1SIQ A;  1JQI A;  3X0Y A;  2ZAF A;  4Q17 A;  3HWC A;  1QDB A;  3EON A;  3D9G A;  4M9A A;  2E81 A;  4W9U A;  3MDD A;  4X28 A;  4KTO A;  2R0N A;  3B96 A;  3MKH A;  2RFQ A;  3EOM A;  4X28 C;  3MMO A;  3MPJ A;  1FS7 A;  1BUC A;  3BNH A;  2JBS A;  1UDY A;  4Q4U A;  5K3H A;  3MPI A;  3OIB A;  2EBA A;  2CX9 A;  3F29 A;  1T9G A;  3R7K A;  1GU6 A;  4O5M A;  2J7A A;  3LGQ A;  4KCF A;  3NF4 A;  1R2J A;  4XVX A;  1FS9 A;  3BNG A;  4OO2 A;  2DDH A;  5K3I A;  2RDZ A;  3D1I A;  1EGD A;  2R0M A;  4Q1O A;  3TTB A;  3AFF A;  3AFE A;  2IX5 A;  3GM6 A;  4P13 A;  3OWA A;  2VR0 A;  2VIG A;  3M9V A;  2IX6 A;  3UBR A;  4IV6 A;  3LG1 A;  2WBI A;  2YYK A;  4Q0T A;  4Q5B A;  2YYJ A;  2PG0 A;  3SWO A;  4ZXV A;  2UXW A;  3GNC A;  1EGE A;  3MXL A;  3TOR A;  2REH A;  3D6B A;  4WJY A;  4L1F A;  5K3G A;  2D29 A;  2C0U A;  3PFD A;  4NXL A;  4L3Z A;  3S7W A;  2JBT A;  4DOY A;  3X0X A;  1FS8 A;  3OWM A;  2JBR A;  3L1T A;  2YYM A;  4U83 A;  3RKH A;  3FCJ A;  1IVH A;  3D9F A;  2ZO5 A;  4G5E A;  4RM7 A;  1RX0 A;  3D9D A;  3MDE A;  3P4T A;  2YYI A;  3GQT A;  3II9 A;  4L3X A;  2DVL A;  1W07 A;  2C12 A;  5K3J A;  2JIF A;  3SF6 A;  3BNF A;  2OT4 A;  1WS9 A;  4L38 A;  2FON A;  1SIR A;  3SXQ A;  2RF7 A;  3BNJ A;  3D9E A;  2Z1Q A;  2YYG A; 
#chains in the Genus database with same CATH topology
 2ZDX A;  4E02 A;  1OAH A;  3UU9 A;  3TZ5 A;  2YYL A;  4FZ4 A;  4IRN A;  4L3Y A;  3VAD A;  2OR0 A;  4MPE A;  2EBH X;  3Q23 A;  2E80 A;  2OEV A;  1U8V A;  3VKH A;  4Q5C A;  1IS2 A;  2A1T A;  4N5F A;  2R05 A;  4HR3 A;  3FO3 A;  3SCE A;  4F0X A;  4JEK A;  2PNR A;  4MPC A;  1EGC A;  1UKW A;  4ZYJ A;  1JM6 A;  4HKS A;  1K90 A;  4FF2 A;  1SIQ A;  1JQI A;  3X0Y A;  2CJ8 A;  4V26 A;  2ZAF A;  4Q17 A;  4E00 A;  5M4P A;  3HWC A;  4KS9 A;  1XFW A;  1PI1 A;  1QDB A;  3EON A;  3D9G A;  4M9A A;  4J1V A;  2Q8I A;  3C2P A;  2CJ4 A;  2E81 A;  4W9U A;  1Y0V A;  1S26 A;  3MDD A;  4X28 A;  1XFY A;  4AKI A;  4KTO A;  2EC5 A;  2OJQ A;  2Q8H A;  2R0N A;  3B96 A;  1Y8O A;  3MKH A;  2AO2 A;  4V25 A;  1XFX A;  2RFQ A;  3EOM A;  1SC5 A;  2OEX A;  4X28 C;  2ZKJ A;  3MMO A;  2VF1 A;  3TZ4 A;  3MPJ A;  2GBB A;  1R3B A;  1FS7 A;  1Y8N A;  1BUC A;  3BNH A;  3U33 A;  2JBS A;  2R03 A;  1UDY A;  4Q4U A;  1GKX A;  3Q22 A;  5K3H A;  1SK6 A;  3MPI A;  3OIB A;  2E0A A;  2LFW A;  3C46 A;  4H81 A;  2EBA A;  2Q8G A;  5B6B A;  4MP2 A;  1RJ4 A;  2CX9 A;  2BU2 A;  3F29 A;  1T9G A;  3R7K A;  1GU6 A;  4O5M A;  2J7A A;  5B5V A;  5BRK A;  5EZ3 A;  2EBF X;  3LGQ A;  1XFU A;  4KCF A;  3NF4 A;  4JIO A;  1R2J A;  4AKG A;  4XVX A;  1FS9 A;  2XS1 A;  3BNG A;  2HJN A;  2AZE A;  2DDH A;  5K3I A;  2RDZ A;  4OO2 A;  2BU6 A;  3VKG A;  3DJL A;  2BTZ A;  3D1I A;  3CE2 A;  1EGD A;  2R0M A;  4Q1O A;  3TTB A;  3AFF A;  3AFE A;  2IX5 A;  2CJ6 A;  3D2R A;  4P13 A;  3OWA A;  3GM6 A;  1RP3 A;  1XFV A;  2VR0 A;  4HKR A;  2VIG A;  3M9V A;  1X91 A;  2IX6 A;  1XFZ A;  1GKZ A;  2YGW A;  3UBR A;  3Q0A A;  1X90 A;  4IV6 A;  1PK0 A;  2F6L A;  3LG1 A;  4H7Q A;  4LQQ B;  2WBI A;  1X8Z A;  2YYK A;  4Q0T A;  4Q5B A;  4QIC A;  2CJ7 A;  2BU8 A;  2YYJ A;  2PG0 A;  5M4N A;  3SWO A;  4ZXV A;  2Q8F A;  1Y8P A;  2UXW A;  3GNC A;  1EGE A;  2PO4 A;  4FF4 A;  3MXL A;  4G97 A;  4H85 A;  3TOR A;  2REH A;  3D6B A;  1GJV A;  1K93 A;  4L1F A;  5K3G A;  2FP1 A;  2D29 A;  4WJY A;  2C0U A;  3PFD A;  4NXL A;  3X29 A;  4L3Z A;  3TZ0 A;  4AI6 A;  3S7W A;  4AKH A;  2JBT A;  4DOY A;  3X0X A;  1FS8 A;  2R02 A;  3OWM A;  2JBR A;  3L1T A;  2YYM A;  4P79 A;  5GJW E;  4U83 A;  3RKH A;  4DZY A;  2BU5 A;  4FF3 A;  2BU7 A;  3FCJ A;  5J6A A;  1IVH A;  2QR4 A;  5BRM A;  3N0R A;  2XS8 A;  3D9F A;  2ZO5 A;  4G5E A;  4RM7 A;  1RX0 A;  3D9D A;  3MDE A;  1RJ1 A;  4KSA A;  3P4T A;  5B5W A;  1LVC A;  3Q24 A;  2YYI A;  4JIZ A;  3GQT A;  3II9 A;  4LQS B;  4L3X A;  2DVL A;  1W07 A;  2C12 A;  5K3J A;  2CJ5 A;  3CRK A;  4KSF A;  2JIF A;  3SF6 A;  3BNF A;  1XG2 B;  4MP7 A;  2OT4 A;  3TZ2 A;  2ZDY A;  5J71 A;  5M4M A;  1WS9 A;  5GJV E;  4L38 A;  2FON A;  1SIR A;  3CRL A;  3SXQ A;  4FF1 A;  2FP2 A;  2RF7 A;  3KML A;  3BNJ A;  3C3L A;  2XQR B;  4MPN A;  4E01 A;  5M4K A;  3D9E A;  2Z1Q A;  2YYG A;  1K8T A; 
#chains in the Genus database with same CATH homology
 1OAH A;  3UU9 A;  2YYL A;  4IRN A;  4L3Y A;  2OR0 A;  2E80 A;  1U8V A;  4Q5C A;  1IS2 A;  2A1T A;  4N5F A;  3FO3 A;  4HR3 A;  3SCE A;  4JEK A;  1EGC A;  1UKW A;  4ZYJ A;  1SIQ A;  1JQI A;  3X0Y A;  2ZAF A;  4Q17 A;  3HWC A;  1QDB A;  3EON A;  3D9G A;  4M9A A;  2E81 A;  4W9U A;  3MDD A;  4X28 A;  4KTO A;  2R0N A;  3B96 A;  3MKH A;  2RFQ A;  3EOM A;  4X28 C;  3MMO A;  3MPJ A;  1FS7 A;  1BUC A;  3BNH A;  2JBS A;  1UDY A;  4Q4U A;  5K3H A;  3MPI A;  3OIB A;  2EBA A;  2CX9 A;  3F29 A;  1T9G A;  3R7K A;  1GU6 A;  4O5M A;  2J7A A;  3LGQ A;  4KCF A;  3NF4 A;  1R2J A;  4XVX A;  1FS9 A;  3BNG A;  4OO2 A;  2DDH A;  5K3I A;  2RDZ A;  3D1I A;  1EGD A;  2R0M A;  4Q1O A;  3TTB A;  3AFF A;  3AFE A;  2IX5 A;  3GM6 A;  4P13 A;  3OWA A;  2VR0 A;  2VIG A;  3M9V A;  2IX6 A;  3UBR A;  4IV6 A;  3LG1 A;  2WBI A;  2YYK A;  4Q0T A;  4Q5B A;  2YYJ A;  2PG0 A;  3SWO A;  4ZXV A;  2UXW A;  3GNC A;  1EGE A;  3MXL A;  3TOR A;  2REH A;  3D6B A;  4WJY A;  4L1F A;  5K3G A;  2D29 A;  2C0U A;  3PFD A;  4NXL A;  4L3Z A;  3S7W A;  2JBT A;  4DOY A;  3X0X A;  1FS8 A;  3OWM A;  2JBR A;  3L1T A;  2YYM A;  4U83 A;  3RKH A;  3FCJ A;  1IVH A;  3D9F A;  2ZO5 A;  4G5E A;  4RM7 A;  1RX0 A;  3D9D A;  3MDE A;  3P4T A;  2YYI A;  3GQT A;  3II9 A;  4L3X A;  2DVL A;  1W07 A;  2C12 A;  5K3J A;  2JIF A;  3SF6 A;  3BNF A;  2OT4 A;  1WS9 A;  4L38 A;  2FON A;  1SIR A;  3SXQ A;  2RF7 A;  3BNJ A;  3D9E A;  2Z1Q A;  2YYG A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...