3B96A

Structural basis for substrate fatty-acyl chain specificity: crystal structure of human very-long-chain acyl-coa dehydrogenase
Total Genus 211
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
211
sequence length
587
structure length
554
Chain Sequence
b'ESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDKGKELSLSLSGLVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Very long-chain specific acyl-CoA dehydrogenase
publication title Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Oxidoreductase
total genus 211
structure length 554
sequence length 587
ec nomenclature ec 1.3.8.9: Very-long-chain acyl-CoA dehydrogenase.
pdb deposition date 2007-11-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 3b96A02
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3b96A04
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3b96A01
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 3b96A03
2E80A 2ZAFA 4N5FA 2E81A 4KCFA 3F29A 3GQTA 2C0UA 2OT4A 1IVHA 1OAHA 4L3YA 5K3IA 3SF6A 1JQIA 2RFQA 3AFEA 4Q5BA 4RM7A 1RX0A 3D9DA 4W9UA 4X28A 2C12A 2REHA 4U83A 3BNHA 3II9A 3BNJA 3FO3A 2JBTA 4WJYA 1FS7A 3SXQA 3BNFA 4L3XA 5K3HA 3EOMA 2Z1QA 2OR0A 2YYLA 3S7WA 1FS9A 2YYKA 4Q5CA 3B96A 3OWAA 3MPIA 2DVLA 2R0MA 3D9FA 4L1FA 3MMOA 2RF7A 1UKWA 4ZXVA 4HR3A 1T9GA 2JBRA 3MDDA 3RKHA 2D29A 4G5EA 2VIGA 3OWMA 1EGCA 3TTBA 3UBRA 3D9GA 2WBIA 3SCEA 4OO2A 2J7AA 2JIFA 3LG1A 2ZO5A 3MDEA 3GNCA 4NXLA 2PG0A 2RDZA 3GM6A 4IRNA 3LGQA 4IV6A 3MPJA 2YYGA 2A1TA 4P13A 2EBAA 3P4TA 3TORA 4Q17A 4M9AA 3SWOA 2YYMA 3M9VA 3R7KA 4L38A 3BNGA 3PFDA 3HWCA 3D9EA 3X0XA 4KTOA 1UDYA 1IS2A 4O5MA 1EGEA 2R0NA 2VR0A 2JBSA 2YYJA 5K3JA 1FS8A 3D6BA 1QDBA 4Q0TA 2IX5A 2FONA 2IX6A 3UU9A 3FCJA 3EONA 1BUCA 4ZYJA 1SIQA 3NF4A 1SIRA 4DOYA 3OIBA 2UXWA 1W07A 4X28C 4XVXA 2DDHA 1EGDA 3AFFA 3D1IA 3L1TA 2YYIA 3MKHA 1GU6A 1WS9A 1U8VA 4Q1OA 5K3GA 3MXLA 3X0YA 1R2JA 4L3ZA 2CX9A 4JEKA 4Q4UA
chains in the Genus database with same CATH superfamily
2E80A 2ZAFA 2ZDYA 4N5FA 1X90A 2E81A 1RP3A 2Q8FA 4KCFA 1XG2B 3CRKA 4AI6A 1X8ZA 3F29A 3GQTA 3TZ2A 2C0UA 1XFXA 3X29A 2OT4A 4HKRA 2BU7A 1Y8PA 2BU8A 3C46A 1IVHA 3TZ4A 4AKIA 2BU6A 3C2PA 2CJ7A 5EZ3A 2CJ5A 1GKZA 3CE2A 5B6BA 1OAHA 4L3YA 1SC5A 2OJQA 5K3IA 3CRLA 3SF6A 1JQIA 2RFQA 3AFEA 4Q5BA 4RM7A 3VADA 4AKGA 2OEVA 1RX0A 3D9DA 4W9UA 4X28A 1SK6A 4MP7A 2C12A 2REHA 4U83A 1GJVA 3BNHA 3II9A 5GJWE 3BNJA 3FO3A 2ZKJA 2JBTA 4WJYA 1FS7A 3SXQA 2CJ6A 3BNFA 4KSAA 1XFZA 4L3XA 5B5WA 5BRKA 1XFVA 4MP2A 5K3HA 3EOMA 2Z1QA 2OR0A 2OEXA 2GBBA 2YYLA 3S7WA 1FS9A 3VKGA 2YYKA 1X91A 4MPNA 4Q5CA 3B96A 3OWAA 3C3LA 3MPIA 5J71A 3Q23A 5B5VA 4E01A 2DVLA 2R0MA 3D9FA 4L1FA 1S26A 2QR4A 3MMOA 4H81A 2CJ4A 2RF7A 2EBHX 2Q8GA 1K8TA 1XFYA 2BTZA 1UKWA 4G97A 4ZXVA 2CJ8A 4HR3A 4F0XA 2PNRA 4LQQB 1T9GA 2JBRA 3MDDA 3RKHA 2FP2A 2Q8HA 2D29A 3D2RA 4FF3A 4G5EA 2VIGA 3OWMA 5M4MA 2AZEA 1EGCA 3TTBA 3TZ5A 3UBRA 3D9GA 2WBIA 2YGWA 3SCEA 4OO2A 4QICA 2J7AA 5BRMA 2JIFA 3LG1A 1XFWA 4E00A 1R3BA 1Y8OA 2ZO5A 3MDEA 3GNCA 2BU5A 4NXLA 4KS9A 2PG0A 1Y8NA 2RDZA 3GM6A 4IRNA 1K93A 4IV6A 2ZDXA 3LGQA 4FZ4A 4H7QA 4MPEA 3MPJA 2XQRB 2YYGA 4P79A 2HJNA 4AKHA 2R02A 2A1TA 4JIOA 4P13A 2EBAA 2EC5A 2F6LA 5M4PA 3P4TA 4E02A 1Y0VA 1GKXA 4Q17A 3TORA 4M9AA 3SWOA 2YYMA 2AO2A 3M9VA 2R05A 3R7KA 4L38A 3BNGA 3PFDA 2BU2A 3HWCA 3D9EA 3X0XA 3Q22A 4V26A 4J1VA 4KTOA 4FF1A 1PK0A 1UDYA 1XFUA 2PO4A 1IS2A 4O5MA 5M4KA 1EGEA 2R0NA 2VR0A 2JBSA 2YYJA 5K3JA 1FS8A 3DJLA 3D6BA 1QDBA 3TZ0A 4Q0TA 2IX5A 2FONA 2IX6A 2EBFX 3FCJA 3EONA 2R03A 5GJVE 3UU9A 1BUCA 4ZYJA 4DZYA 1SIQA 5J6AA 3VKHA 2LFWA 1K90A 1LVCA 1JM6A 3NF4A 1SIRA 4DOYA 4FF2A 2FP1A 2E0AA 4MPCA 3OIBA 4FF4A 2UXWA 1W07A 2XS1A 2XS8A 4X28C 4XVXA 3N0RA 4JIZA 5M4NA 1PI1A 3KMLA 2DDHA 1EGDA 1RJ4A 3AFFA 4HKSA 3D1IA 3L1TA 2YYIA 3Q24A 3MKHA 1GU6A 1WS9A 1U8VA 4KSFA 4LQSB 5K3GA 4Q1OA 2Q8IA 3MXLA 1RJ1A 3Q0AA 4H85A 3X0YA 1R2JA 4V25A 4L3ZA 2CX9A 2VF1A 3U33A 4JEKA 4Q4UA
chains in the Genus database with same CATH topology
2E80A 2ZAFA 4N5FA 2E81A 4KCFA 3F29A 3GQTA 2C0UA 2OT4A 1IVHA 1OAHA 4L3YA 5K3IA 3SF6A 1JQIA 2RFQA 3AFEA 4Q5BA 4RM7A 1RX0A 3D9DA 4W9UA 4X28A 2C12A 2REHA 4U83A 3BNHA 3II9A 3BNJA 3FO3A 2JBTA 4WJYA 1FS7A 3SXQA 3BNFA 4L3XA 5K3HA 3EOMA 2Z1QA 2OR0A 2YYLA 3S7WA 1FS9A 2YYKA 4Q5CA 3B96A 3OWAA 3MPIA 2DVLA 2R0MA 3D9FA 4L1FA 3MMOA 2RF7A 1UKWA 4ZXVA 4HR3A 1T9GA 2JBRA 3MDDA 3RKHA 2D29A 4G5EA 2VIGA 3OWMA 1EGCA 3TTBA 3UBRA 3D9GA 2WBIA 3SCEA 4OO2A 2J7AA 2JIFA 3LG1A 2ZO5A 3MDEA 3GNCA 4NXLA 2PG0A 2RDZA 3GM6A 4IRNA 3LGQA 4IV6A 3MPJA 2YYGA 2A1TA 4P13A 2EBAA 3P4TA 3TORA 4Q17A 4M9AA 3SWOA 2YYMA 3M9VA 3R7KA 4L38A 3BNGA 3PFDA 3HWCA 3D9EA 3X0XA 4KTOA 1UDYA 1IS2A 4O5MA 1EGEA 2R0NA 2VR0A 2JBSA 2YYJA 5K3JA 1FS8A 3D6BA 1QDBA 4Q0TA 2IX5A 2FONA 2IX6A 3UU9A 3FCJA 3EONA 1BUCA 4ZYJA 1SIQA 3NF4A 1SIRA 4DOYA 3OIBA 2UXWA 1W07A 4X28C 4XVXA 2DDHA 1EGDA 3AFFA 3D1IA 3L1TA 2YYIA 3MKHA 1GU6A 1WS9A 1U8VA 4Q1OA 5K3GA 3MXLA 3X0YA 1R2JA 4L3ZA 2CX9A 4JEKA 4Q4UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E80 A;  2ZAF A;  4N5F A;  2E81 A;  4KCF A;  3F29 A;  3GQT A;  2C0U A;  2OT4 A;  1IVH A;  1OAH A;  4L3Y A;  5K3I A;  3SF6 A;  1JQI A;  2RFQ A;  3AFE A;  4Q5B A;  4RM7 A;  1RX0 A;  3D9D A;  4W9U A;  4X28 A;  2C12 A;  2REH A;  4U83 A;  3BNH A;  3II9 A;  3BNJ A;  3FO3 A;  2JBT A;  4WJY A;  1FS7 A;  3SXQ A;  3BNF A;  4L3X A;  5K3H A;  3EOM A;  2Z1Q A;  2OR0 A;  2YYL A;  3S7W A;  1FS9 A;  2YYK A;  4Q5C A;  3B96 A;  3OWA A;  3MPI A;  2DVL A;  2R0M A;  3D9F A;  4L1F A;  3MMO A;  2RF7 A;  1UKW A;  4ZXV A;  4HR3 A;  1T9G A;  2JBR A;  3MDD A;  3RKH A;  2D29 A;  4G5E A;  2VIG A;  3OWM A;  1EGC A;  3TTB A;  3UBR A;  3D9G A;  2WBI A;  3SCE A;  4OO2 A;  2J7A A;  2JIF A;  3LG1 A;  2ZO5 A;  3MDE A;  3GNC A;  4NXL A;  2PG0 A;  2RDZ A;  3GM6 A;  4IRN A;  3LGQ A;  4IV6 A;  3MPJ A;  2YYG A;  2A1T A;  4P13 A;  2EBA A;  3P4T A;  3TOR A;  4Q17 A;  4M9A A;  3SWO A;  2YYM A;  3M9V A;  3R7K A;  4L38 A;  3BNG A;  3PFD A;  3HWC A;  3D9E A;  3X0X A;  4KTO A;  1UDY A;  1IS2 A;  4O5M A;  1EGE A;  2R0N A;  2VR0 A;  2JBS A;  2YYJ A;  5K3J A;  1FS8 A;  3D6B A;  1QDB A;  4Q0T A;  2IX5 A;  2FON A;  2IX6 A;  3UU9 A;  3FCJ A;  3EON A;  1BUC A;  4ZYJ A;  1SIQ A;  3NF4 A;  1SIR A;  4DOY A;  3OIB A;  2UXW A;  1W07 A;  4X28 C;  4XVX A;  2DDH A;  1EGD A;  3AFF A;  3D1I A;  3L1T A;  2YYI A;  3MKH A;  1GU6 A;  1WS9 A;  1U8V A;  4Q1O A;  5K3G A;  3MXL A;  3X0Y A;  1R2J A;  4L3Z A;  2CX9 A;  4JEK A;  4Q4U A; 
#chains in the Genus database with same CATH topology
 2E80 A;  2ZAF A;  2ZDY A;  4N5F A;  1X90 A;  2E81 A;  1RP3 A;  2Q8F A;  4KCF A;  1XG2 B;  3CRK A;  4AI6 A;  1X8Z A;  3F29 A;  3GQT A;  3TZ2 A;  2C0U A;  1XFX A;  3X29 A;  2OT4 A;  4HKR A;  2BU7 A;  1Y8P A;  2BU8 A;  3C46 A;  1IVH A;  3TZ4 A;  4AKI A;  2BU6 A;  3C2P A;  2CJ7 A;  5EZ3 A;  2CJ5 A;  1GKZ A;  3CE2 A;  5B6B A;  1OAH A;  4L3Y A;  1SC5 A;  2OJQ A;  5K3I A;  3CRL A;  3SF6 A;  1JQI A;  2RFQ A;  3AFE A;  4Q5B A;  4RM7 A;  3VAD A;  4AKG A;  2OEV A;  1RX0 A;  3D9D A;  4W9U A;  4X28 A;  1SK6 A;  4MP7 A;  2C12 A;  2REH A;  4U83 A;  1GJV A;  3BNH A;  3II9 A;  5GJW E;  3BNJ A;  3FO3 A;  2ZKJ A;  2JBT A;  4WJY A;  1FS7 A;  3SXQ A;  2CJ6 A;  3BNF A;  4KSA A;  1XFZ A;  4L3X A;  5B5W A;  5BRK A;  1XFV A;  4MP2 A;  5K3H A;  3EOM A;  2Z1Q A;  2OR0 A;  2OEX A;  2GBB A;  2YYL A;  3S7W A;  1FS9 A;  3VKG A;  2YYK A;  1X91 A;  4MPN A;  4Q5C A;  3B96 A;  3OWA A;  3C3L A;  3MPI A;  5J71 A;  3Q23 A;  5B5V A;  4E01 A;  2DVL A;  2R0M A;  3D9F A;  4L1F A;  1S26 A;  2QR4 A;  3MMO A;  4H81 A;  2CJ4 A;  2RF7 A;  2EBH X;  2Q8G A;  1K8T A;  1XFY A;  2BTZ A;  1UKW A;  4G97 A;  4ZXV A;  2CJ8 A;  4HR3 A;  4F0X A;  2PNR A;  4LQQ B;  1T9G A;  2JBR A;  3MDD A;  3RKH A;  2FP2 A;  2Q8H A;  2D29 A;  3D2R A;  4FF3 A;  4G5E A;  2VIG A;  3OWM A;  5M4M A;  2AZE A;  1EGC A;  3TTB A;  3TZ5 A;  3UBR A;  3D9G A;  2WBI A;  2YGW A;  3SCE A;  4OO2 A;  4QIC A;  2J7A A;  5BRM A;  2JIF A;  3LG1 A;  1XFW A;  4E00 A;  1R3B A;  1Y8O A;  2ZO5 A;  3MDE A;  3GNC A;  2BU5 A;  4NXL A;  4KS9 A;  2PG0 A;  1Y8N A;  2RDZ A;  3GM6 A;  4IRN A;  1K93 A;  4IV6 A;  2ZDX A;  3LGQ A;  4FZ4 A;  4H7Q A;  4MPE A;  3MPJ A;  2XQR B;  2YYG A;  4P79 A;  2HJN A;  4AKH A;  2R02 A;  2A1T A;  4JIO A;  4P13 A;  2EBA A;  2EC5 A;  2F6L A;  5M4P A;  3P4T A;  4E02 A;  1Y0V A;  1GKX A;  4Q17 A;  3TOR A;  4M9A A;  3SWO A;  2YYM A;  2AO2 A;  3M9V A;  2R05 A;  3R7K A;  4L38 A;  3BNG A;  3PFD A;  2BU2 A;  3HWC A;  3D9E A;  3X0X A;  3Q22 A;  4V26 A;  4J1V A;  4KTO A;  4FF1 A;  1PK0 A;  1UDY A;  1XFU A;  2PO4 A;  1IS2 A;  4O5M A;  5M4K A;  1EGE A;  2R0N A;  2VR0 A;  2JBS A;  2YYJ A;  5K3J A;  1FS8 A;  3DJL A;  3D6B A;  1QDB A;  3TZ0 A;  4Q0T A;  2IX5 A;  2FON A;  2IX6 A;  2EBF X;  3FCJ A;  3EON A;  2R03 A;  5GJV E;  3UU9 A;  1BUC A;  4ZYJ A;  4DZY A;  1SIQ A;  5J6A A;  3VKH A;  2LFW A;  1K90 A;  1LVC A;  1JM6 A;  3NF4 A;  1SIR A;  4DOY A;  4FF2 A;  2FP1 A;  2E0A A;  4MPC A;  3OIB A;  4FF4 A;  2UXW A;  1W07 A;  2XS1 A;  2XS8 A;  4X28 C;  4XVX A;  3N0R A;  4JIZ A;  5M4N A;  1PI1 A;  3KML A;  2DDH A;  1EGD A;  1RJ4 A;  3AFF A;  4HKS A;  3D1I A;  3L1T A;  2YYI A;  3Q24 A;  3MKH A;  1GU6 A;  1WS9 A;  1U8V A;  4KSF A;  4LQS B;  5K3G A;  4Q1O A;  2Q8I A;  3MXL A;  1RJ1 A;  3Q0A A;  4H85 A;  3X0Y A;  1R2J A;  4V25 A;  4L3Z A;  2CX9 A;  2VF1 A;  3U33 A;  4JEK A;  4Q4U A; 
#chains in the Genus database with same CATH homology
 2E80 A;  2ZAF A;  4N5F A;  2E81 A;  4KCF A;  3F29 A;  3GQT A;  2C0U A;  2OT4 A;  1IVH A;  1OAH A;  4L3Y A;  5K3I A;  3SF6 A;  1JQI A;  2RFQ A;  3AFE A;  4Q5B A;  4RM7 A;  1RX0 A;  3D9D A;  4W9U A;  4X28 A;  2C12 A;  2REH A;  4U83 A;  3BNH A;  3II9 A;  3BNJ A;  3FO3 A;  2JBT A;  4WJY A;  1FS7 A;  3SXQ A;  3BNF A;  4L3X A;  5K3H A;  3EOM A;  2Z1Q A;  2OR0 A;  2YYL A;  3S7W A;  1FS9 A;  2YYK A;  4Q5C A;  3B96 A;  3OWA A;  3MPI A;  2DVL A;  2R0M A;  3D9F A;  4L1F A;  3MMO A;  2RF7 A;  1UKW A;  4ZXV A;  4HR3 A;  1T9G A;  2JBR A;  3MDD A;  3RKH A;  2D29 A;  4G5E A;  2VIG A;  3OWM A;  1EGC A;  3TTB A;  3UBR A;  3D9G A;  2WBI A;  3SCE A;  4OO2 A;  2J7A A;  2JIF A;  3LG1 A;  2ZO5 A;  3MDE A;  3GNC A;  4NXL A;  2PG0 A;  2RDZ A;  3GM6 A;  4IRN A;  3LGQ A;  4IV6 A;  3MPJ A;  2YYG A;  2A1T A;  4P13 A;  2EBA A;  3P4T A;  3TOR A;  4Q17 A;  4M9A A;  3SWO A;  2YYM A;  3M9V A;  3R7K A;  4L38 A;  3BNG A;  3PFD A;  3HWC A;  3D9E A;  3X0X A;  4KTO A;  1UDY A;  1IS2 A;  4O5M A;  1EGE A;  2R0N A;  2VR0 A;  2JBS A;  2YYJ A;  5K3J A;  1FS8 A;  3D6B A;  1QDB A;  4Q0T A;  2IX5 A;  2FON A;  2IX6 A;  3UU9 A;  3FCJ A;  3EON A;  1BUC A;  4ZYJ A;  1SIQ A;  3NF4 A;  1SIR A;  4DOY A;  3OIB A;  2UXW A;  1W07 A;  4X28 C;  4XVX A;  2DDH A;  1EGD A;  3AFF A;  3D1I A;  3L1T A;  2YYI A;  3MKH A;  1GU6 A;  1WS9 A;  1U8V A;  4Q1O A;  5K3G A;  3MXL A;  3X0Y A;  1R2J A;  4L3Z A;  2CX9 A;  4JEK A;  4Q4U A; 
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similar chains in the Genus database (?% sequence similarity)
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