3B96A

Structural basis for substrate fatty-acyl chain specificity: crystal structure of human very-long-chain acyl-coa dehydrogenase
Total Genus 211
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
211
sequence length
587
structure length
554
Chain Sequence
ESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDKGKELSLSLSGLVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Very long-chain specific acyl-CoA dehydrogenase
publication title Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Oxidoreductase
total genus 211
structure length 554
sequence length 587
ec nomenclature ec 1.3.8.9: Very-long-chain acyl-CoA dehydrogenase.
pdb deposition date 2007-11-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 3b96A02
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3b96A04
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3b96A01
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 3b96A03
3RKHA 4Q1OA 4WJYA 2ZO5A 2C0UA 2C12A 2RFQA 3SF6A 3UU9A 4Q5BA 3L1TA 3MMOA 5K3GA 2E80A 3LGQA 1SIQA 3FO3A 3NF4A 3FCJA 4M9AA 3P4TA 1R2JA 2WBIA 3GQTA 2JBRA 3R7KA 1FS9A 3SWOA 2IX6A 4X28C 4KTOA 3HWCA 3S7WA 4HR3A 3X0XA 2Z1QA 2DVLA 2FONA 4L38A 3SXQA 2J7AA 1JQIA 1FS7A 4Q4UA 2PG0A 4Q0TA 3TORA 3UBRA 2RF7A 2JBSA 3D6BA 4XVXA 4Q5CA 3EONA 4JEKA 2YYMA 3D9FA 3II9A 4L3YA 1IS2A 1EGCA 2ZAFA 4P13A 4NXLA 3X0YA 2EBAA 1RX0A 3OWAA 2D29A 4IRNA 4X28A 2JIFA 4KCFA 2CX9A 3D1IA 3GM6A 2YYIA 2R0NA 2YYLA 1EGEA 2UXWA 3D9GA 5K3IA 2RDZA 4L1FA 1UDYA 3D9EA 4N5FA 3MPJA 4ZYJA 3TTBA 2E81A 1GU6A 3MDDA 3AFEA 3B96A 3BNJA 2IX5A 4IV6A 5K3HA 4OO2A 4L3XA 3MXLA 1BUCA 1U8VA 3MDEA 3OWMA 1W07A 3F29A 3MKHA 2OR0A 2YYGA 4W9UA 2OT4A 3EOMA 3LG1A 3BNHA 3M9VA 3BNGA 2JBTA 4RM7A 1FS8A 1EGDA 5K3JA 2YYKA 2YYJA 3SCEA 1QDBA 3GNCA 4L3ZA 2REHA 1SIRA 1WS9A 1IVHA 3MPIA 3OIBA 4DOYA 2VR0A 1OAHA 4Q17A 2R0MA 4U83A 1UKWA 2A1TA 2DDHA 2VIGA 1T9GA 3D9DA 4O5MA 4ZXVA 3BNFA 3PFDA 4G5EA 3AFFA
chains in the Genus database with same CATH superfamily
4HKSA 3RKHA 4Q1OA 1X90A 4WJYA 3TZ4A 2EBFX 2ZO5A 2EBHX 2C0UA 2ZDYA 3CE2A 2C12A 1XFVA 1LVCA 2RFQA 2BU8A 3SF6A 3UU9A 4Q5BA 3L1TA 2ZDXA 3MMOA 4V25A 5K3GA 2OJQA 3Q22A 2E80A 1R3BA 2R05A 3LGQA 1SIQA 2PO4A 3NF4A 3FO3A 3VKHA 3FCJA 4M9AA 3P4TA 1R2JA 2WBIA 1XFUA 4FF2A 3GQTA 2HJNA 2JBRA 3R7KA 1Y8PA 1FS9A 1SK6A 3SWOA 2IX6A 4H7QA 2OEVA 4X28C 4KTOA 5M4NA 5BRKA 3HWCA 2Q8GA 3S7WA 3TZ0A 4HR3A 4E02A 1XFZA 2BU7A 3X0XA 2Z1QA 2DVLA 2FONA 2OEXA 4L38A 3SXQA 3X29A 2J7AA 4MPEA 1Y8OA 4MPNA 1JQIA 1FS7A 2BU5A 4Q4UA 5BRMA 2PG0A 2VF1A 4MPCA 2E0AA 4FF4A 1RJ4A 4Q0TA 1XFWA 5GJWE 3TORA 3UBRA 2RF7A 2JBSA 3D6BA 4MP7A 4XVXA 4JIOA 2Q8HA 4Q5CA 1PI1A 5EZ3A 4G97A 3EONA 4AKGA 4JEKA 2FP2A 2YYMA 3D9FA 2BU6A 3II9A 1JM6A 4L3YA 1IS2A 1EGCA 2ZAFA 4P13A 4H85A 4NXLA 3X0YA 1K93A 2EBAA 3D2RA 4KS9A 3DJLA 1RX0A 1GJVA 5B5WA 3OWAA 4LQSB 1SC5A 4FF1A 2D29A 2XS1A 5B5VA 4AKIA 5J71A 2AO2A 4IRNA 4X28A 1RP3A 2JIFA 3VADA 4KCFA 2CX9A 3D1IA 3GM6A 4FZ4A 5M4KA 2YYIA 5GJVE 2R0NA 2PNRA 2YYLA 1EGEA 2UXWA 1GKZA 3D9GA 4JIZA 1XFYA 5K3IA 4V26A 2Q8IA 4DZYA 4E01A 1XG2B 3KMLA 2RDZA 4L1FA 3TZ5A 2CJ7A 1S26A 4MP2A 1UDYA 3D9EA 2BU2A 4N5FA 3MPJA 4ZYJA 2CJ6A 3Q0AA 3TTBA 2E81A 1GU6A 3MDDA 1RJ1A 3AFEA 3CRKA 2FP1A 3N0RA 3B96A 1Y0VA 3BNJA 4KSFA 2IX5A 4IV6A 5K3HA 2GBBA 2YGWA 3MXLA 4L3XA 4OO2A 3C3LA 1BUCA 3CRLA 2BTZA 1U8VA 3MDEA 3OWMA 4KSAA 2CJ4A 4J1VA 4F0XA 1W07A 2QR4A 3MKHA 2OR0A 3F29A 4H81A 1K90A 2YYGA 4W9UA 2OT4A 3Q23A 3EOMA 3U33A 3LG1A 2R02A 3BNHA 3TZ2A 2F6LA 3M9VA 3BNGA 2JBTA 2R03A 2XS8A 4HKRA 4RM7A 1FS8A 1EGDA 5K3JA 3VKGA 1XFXA 2YYKA 2YYJA 3SCEA 2XQRB 1QDBA 1X8ZA 3GNCA 2LFWA 3Q24A 4L3ZA 1PK0A 2REHA 3C2PA 1SIRA 5M4MA 1WS9A 1IVHA 5J6AA 3MPIA 3OIBA 4DOYA 2AZEA 4AKHA 5M4PA 2ZKJA 2VR0A 1OAHA 4Q17A 2Q8FA 4E00A 2R0MA 4U83A 1X91A 2CJ5A 4FF3A 4AI6A 2EC5A 5B6BA 1UKWA 2A1TA 3C46A 2DDHA 2VIGA 1T9GA 3D9DA 4O5MA 4ZXVA 2CJ8A 3BNFA 4LQQB 4QICA 4P79A 3PFDA 1GKXA 1Y8NA 4G5EA 1K8TA 3AFFA
chains in the Genus database with same CATH topology
3RKHA 4Q1OA 4WJYA 2ZO5A 2C0UA 2C12A 2RFQA 3SF6A 3UU9A 4Q5BA 3L1TA 3MMOA 5K3GA 2E80A 3LGQA 1SIQA 3FO3A 3NF4A 3FCJA 4M9AA 3P4TA 1R2JA 2WBIA 3GQTA 2JBRA 3R7KA 1FS9A 3SWOA 2IX6A 4X28C 4KTOA 3HWCA 3S7WA 4HR3A 3X0XA 2Z1QA 2DVLA 2FONA 4L38A 3SXQA 2J7AA 1JQIA 1FS7A 4Q4UA 2PG0A 4Q0TA 3TORA 3UBRA 2RF7A 2JBSA 3D6BA 4XVXA 4Q5CA 3EONA 4JEKA 2YYMA 3D9FA 3II9A 4L3YA 1IS2A 1EGCA 2ZAFA 4P13A 4NXLA 3X0YA 2EBAA 1RX0A 3OWAA 2D29A 4IRNA 4X28A 2JIFA 4KCFA 2CX9A 3D1IA 3GM6A 2YYIA 2R0NA 2YYLA 1EGEA 2UXWA 3D9GA 5K3IA 2RDZA 4L1FA 1UDYA 3D9EA 4N5FA 3MPJA 4ZYJA 3TTBA 2E81A 1GU6A 3MDDA 3AFEA 3B96A 3BNJA 2IX5A 4IV6A 5K3HA 4OO2A 4L3XA 3MXLA 1BUCA 1U8VA 3MDEA 3OWMA 1W07A 3F29A 3MKHA 2OR0A 2YYGA 4W9UA 2OT4A 3EOMA 3LG1A 3BNHA 3M9VA 3BNGA 2JBTA 4RM7A 1FS8A 1EGDA 5K3JA 2YYKA 2YYJA 3SCEA 1QDBA 3GNCA 4L3ZA 2REHA 1SIRA 1WS9A 1IVHA 3MPIA 3OIBA 4DOYA 2VR0A 1OAHA 4Q17A 2R0MA 4U83A 1UKWA 2A1TA 2DDHA 2VIGA 1T9GA 3D9DA 4O5MA 4ZXVA 3BNFA 3PFDA 4G5EA 3AFFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RKH A;  4Q1O A;  4WJY A;  2ZO5 A;  2C0U A;  2C12 A;  2RFQ A;  3SF6 A;  3UU9 A;  4Q5B A;  3L1T A;  3MMO A;  5K3G A;  2E80 A;  3LGQ A;  1SIQ A;  3FO3 A;  3NF4 A;  3FCJ A;  4M9A A;  3P4T A;  1R2J A;  2WBI A;  3GQT A;  2JBR A;  3R7K A;  1FS9 A;  3SWO A;  2IX6 A;  4X28 C;  4KTO A;  3HWC A;  3S7W A;  4HR3 A;  3X0X A;  2Z1Q A;  2DVL A;  2FON A;  4L38 A;  3SXQ A;  2J7A A;  1JQI A;  1FS7 A;  4Q4U A;  2PG0 A;  4Q0T A;  3TOR A;  3UBR A;  2RF7 A;  2JBS A;  3D6B A;  4XVX A;  4Q5C A;  3EON A;  4JEK A;  2YYM A;  3D9F A;  3II9 A;  4L3Y A;  1IS2 A;  1EGC A;  2ZAF A;  4P13 A;  4NXL A;  3X0Y A;  2EBA A;  1RX0 A;  3OWA A;  2D29 A;  4IRN A;  4X28 A;  2JIF A;  4KCF A;  2CX9 A;  3D1I A;  3GM6 A;  2YYI A;  2R0N A;  2YYL A;  1EGE A;  2UXW A;  3D9G A;  5K3I A;  2RDZ A;  4L1F A;  1UDY A;  3D9E A;  4N5F A;  3MPJ A;  4ZYJ A;  3TTB A;  2E81 A;  1GU6 A;  3MDD A;  3AFE A;  3B96 A;  3BNJ A;  2IX5 A;  4IV6 A;  5K3H A;  4OO2 A;  4L3X A;  3MXL A;  1BUC A;  1U8V A;  3MDE A;  3OWM A;  1W07 A;  3F29 A;  3MKH A;  2OR0 A;  2YYG A;  4W9U A;  2OT4 A;  3EOM A;  3LG1 A;  3BNH A;  3M9V A;  3BNG A;  2JBT A;  4RM7 A;  1FS8 A;  1EGD A;  5K3J A;  2YYK A;  2YYJ A;  3SCE A;  1QDB A;  3GNC A;  4L3Z A;  2REH A;  1SIR A;  1WS9 A;  1IVH A;  3MPI A;  3OIB A;  4DOY A;  2VR0 A;  1OAH A;  4Q17 A;  2R0M A;  4U83 A;  1UKW A;  2A1T A;  2DDH A;  2VIG A;  1T9G A;  3D9D A;  4O5M A;  4ZXV A;  3BNF A;  3PFD A;  4G5E A;  3AFF A; 
#chains in the Genus database with same CATH topology
 4HKS A;  3RKH A;  4Q1O A;  1X90 A;  4WJY A;  3TZ4 A;  2EBF X;  2ZO5 A;  2EBH X;  2C0U A;  2ZDY A;  3CE2 A;  2C12 A;  1XFV A;  1LVC A;  2RFQ A;  2BU8 A;  3SF6 A;  3UU9 A;  4Q5B A;  3L1T A;  2ZDX A;  3MMO A;  4V25 A;  5K3G A;  2OJQ A;  3Q22 A;  2E80 A;  1R3B A;  2R05 A;  3LGQ A;  1SIQ A;  2PO4 A;  3NF4 A;  3FO3 A;  3VKH A;  3FCJ A;  4M9A A;  3P4T A;  1R2J A;  2WBI A;  1XFU A;  4FF2 A;  3GQT A;  2HJN A;  2JBR A;  3R7K A;  1Y8P A;  1FS9 A;  1SK6 A;  3SWO A;  2IX6 A;  4H7Q A;  2OEV A;  4X28 C;  4KTO A;  5M4N A;  5BRK A;  3HWC A;  2Q8G A;  3S7W A;  3TZ0 A;  4HR3 A;  4E02 A;  1XFZ A;  2BU7 A;  3X0X A;  2Z1Q A;  2DVL A;  2FON A;  2OEX A;  4L38 A;  3SXQ A;  3X29 A;  2J7A A;  4MPE A;  1Y8O A;  4MPN A;  1JQI A;  1FS7 A;  2BU5 A;  4Q4U A;  5BRM A;  2PG0 A;  2VF1 A;  4MPC A;  2E0A A;  4FF4 A;  1RJ4 A;  4Q0T A;  1XFW A;  5GJW E;  3TOR A;  3UBR A;  2RF7 A;  2JBS A;  3D6B A;  4MP7 A;  4XVX A;  4JIO A;  2Q8H A;  4Q5C A;  1PI1 A;  5EZ3 A;  4G97 A;  3EON A;  4AKG A;  4JEK A;  2FP2 A;  2YYM A;  3D9F A;  2BU6 A;  3II9 A;  1JM6 A;  4L3Y A;  1IS2 A;  1EGC A;  2ZAF A;  4P13 A;  4H85 A;  4NXL A;  3X0Y A;  1K93 A;  2EBA A;  3D2R A;  4KS9 A;  3DJL A;  1RX0 A;  1GJV A;  5B5W A;  3OWA A;  4LQS B;  1SC5 A;  4FF1 A;  2D29 A;  2XS1 A;  5B5V A;  4AKI A;  5J71 A;  2AO2 A;  4IRN A;  4X28 A;  1RP3 A;  2JIF A;  3VAD A;  4KCF A;  2CX9 A;  3D1I A;  3GM6 A;  4FZ4 A;  5M4K A;  2YYI A;  5GJV E;  2R0N A;  2PNR A;  2YYL A;  1EGE A;  2UXW A;  1GKZ A;  3D9G A;  4JIZ A;  1XFY A;  5K3I A;  4V26 A;  2Q8I A;  4DZY A;  4E01 A;  1XG2 B;  3KML A;  2RDZ A;  4L1F A;  3TZ5 A;  2CJ7 A;  1S26 A;  4MP2 A;  1UDY A;  3D9E A;  2BU2 A;  4N5F A;  3MPJ A;  4ZYJ A;  2CJ6 A;  3Q0A A;  3TTB A;  2E81 A;  1GU6 A;  3MDD A;  1RJ1 A;  3AFE A;  3CRK A;  2FP1 A;  3N0R A;  3B96 A;  1Y0V A;  3BNJ A;  4KSF A;  2IX5 A;  4IV6 A;  5K3H A;  2GBB A;  2YGW A;  3MXL A;  4L3X A;  4OO2 A;  3C3L A;  1BUC A;  3CRL A;  2BTZ A;  1U8V A;  3MDE A;  3OWM A;  4KSA A;  2CJ4 A;  4J1V A;  4F0X A;  1W07 A;  2QR4 A;  3MKH A;  2OR0 A;  3F29 A;  4H81 A;  1K90 A;  2YYG A;  4W9U A;  2OT4 A;  3Q23 A;  3EOM A;  3U33 A;  3LG1 A;  2R02 A;  3BNH A;  3TZ2 A;  2F6L A;  3M9V A;  3BNG A;  2JBT A;  2R03 A;  2XS8 A;  4HKR A;  4RM7 A;  1FS8 A;  1EGD A;  5K3J A;  3VKG A;  1XFX A;  2YYK A;  2YYJ A;  3SCE A;  2XQR B;  1QDB A;  1X8Z A;  3GNC A;  2LFW A;  3Q24 A;  4L3Z A;  1PK0 A;  2REH A;  3C2P A;  1SIR A;  5M4M A;  1WS9 A;  1IVH A;  5J6A A;  3MPI A;  3OIB A;  4DOY A;  2AZE A;  4AKH A;  5M4P A;  2ZKJ A;  2VR0 A;  1OAH A;  4Q17 A;  2Q8F A;  4E00 A;  2R0M A;  4U83 A;  1X91 A;  2CJ5 A;  4FF3 A;  4AI6 A;  2EC5 A;  5B6B A;  1UKW A;  2A1T A;  3C46 A;  2DDH A;  2VIG A;  1T9G A;  3D9D A;  4O5M A;  4ZXV A;  2CJ8 A;  3BNF A;  4LQQ B;  4QIC A;  4P79 A;  3PFD A;  1GKX A;  1Y8N A;  4G5E A;  1K8T A;  3AFF A; 
#chains in the Genus database with same CATH homology
 3RKH A;  4Q1O A;  4WJY A;  2ZO5 A;  2C0U A;  2C12 A;  2RFQ A;  3SF6 A;  3UU9 A;  4Q5B A;  3L1T A;  3MMO A;  5K3G A;  2E80 A;  3LGQ A;  1SIQ A;  3FO3 A;  3NF4 A;  3FCJ A;  4M9A A;  3P4T A;  1R2J A;  2WBI A;  3GQT A;  2JBR A;  3R7K A;  1FS9 A;  3SWO A;  2IX6 A;  4X28 C;  4KTO A;  3HWC A;  3S7W A;  4HR3 A;  3X0X A;  2Z1Q A;  2DVL A;  2FON A;  4L38 A;  3SXQ A;  2J7A A;  1JQI A;  1FS7 A;  4Q4U A;  2PG0 A;  4Q0T A;  3TOR A;  3UBR A;  2RF7 A;  2JBS A;  3D6B A;  4XVX A;  4Q5C A;  3EON A;  4JEK A;  2YYM A;  3D9F A;  3II9 A;  4L3Y A;  1IS2 A;  1EGC A;  2ZAF A;  4P13 A;  4NXL A;  3X0Y A;  2EBA A;  1RX0 A;  3OWA A;  2D29 A;  4IRN A;  4X28 A;  2JIF A;  4KCF A;  2CX9 A;  3D1I A;  3GM6 A;  2YYI A;  2R0N A;  2YYL A;  1EGE A;  2UXW A;  3D9G A;  5K3I A;  2RDZ A;  4L1F A;  1UDY A;  3D9E A;  4N5F A;  3MPJ A;  4ZYJ A;  3TTB A;  2E81 A;  1GU6 A;  3MDD A;  3AFE A;  3B96 A;  3BNJ A;  2IX5 A;  4IV6 A;  5K3H A;  4OO2 A;  4L3X A;  3MXL A;  1BUC A;  1U8V A;  3MDE A;  3OWM A;  1W07 A;  3F29 A;  3MKH A;  2OR0 A;  2YYG A;  4W9U A;  2OT4 A;  3EOM A;  3LG1 A;  3BNH A;  3M9V A;  3BNG A;  2JBT A;  4RM7 A;  1FS8 A;  1EGD A;  5K3J A;  2YYK A;  2YYJ A;  3SCE A;  1QDB A;  3GNC A;  4L3Z A;  2REH A;  1SIR A;  1WS9 A;  1IVH A;  3MPI A;  3OIB A;  4DOY A;  2VR0 A;  1OAH A;  4Q17 A;  2R0M A;  4U83 A;  1UKW A;  2A1T A;  2DDH A;  2VIG A;  1T9G A;  3D9D A;  4O5M A;  4ZXV A;  3BNF A;  3PFD A;  4G5E A;  3AFF A; 
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similar chains in the Genus database (?% sequence similarity)
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