4IV6A

X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis
Total Genus 150
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
150
sequence length
382
structure length
382
Chain Sequence
LTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEELIETMKEIGIFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGHTVVSKLLLLFGTEEQKQKYLPRMATGELRATMALTEPGGGSDLQAMRTVARRDGDDYVINGSKTWISNARRSDLVALMCKTDPDAQPAHKGVSILLVEKVPGFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLGDDEGRGFAQMMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSVGNMLADMGTKLYAARSLLLSAAEKFDAGQRCDMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGGLDI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Acyl-CoA dehydrogenase FadE3
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium smegmatis
total genus 150
structure length 382
sequence length 382
chains with identical sequence B
ec nomenclature ec 1.3.8.1: Short-chain acyl-CoA dehydrogenase.
pdb deposition date 2013-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 4iv6A01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 4iv6A03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 4iv6A02
1WS9A 5K3HA 3NF4A 2OR0A 2UXWA 3SXQA 1IVHA 3X0YA 2E80A 3D9GA 4N5FA 1FS7A 1SIQA 2PG0A 2Z1QA 1FS9A 2A1TA 1T9GA 3EOMA 1IS2A 4KCFA 2R0MA 3RKHA 4RM7A 3BNHA 2FONA 2JIFA 4L1FA 1BUCA 2ZAFA 3GQTA 2IX6A 1RX0A 4O5MA 4WJYA 3UBRA 1QDBA 3MDEA 2JBSA 4KTOA 4X28A 5K3JA 1GU6A 4M9AA 1W07A 2RDZA 4XVXA 4L3XA 3OWMA 3AFFA 3D9DA 3S7WA 2VIGA 3PFDA 2J7AA 3BNFA 3MPIA 2YYLA 2E81A 2EBAA 3MPJA 3SF6A 2IX5A 3R7KA 2C12A 3II9A 2C0UA 3SCEA 3LG1A 4Q5BA 4L38A 3D9FA 3EONA 3D9EA 5K3GA 2YYMA 4L3ZA 4G5EA 3D1IA 3M9VA 4L3YA 3MKHA 4IRNA 1EGDA 1JQIA 4DOYA 2D29A 2YYKA 4U83A 2R0NA 3OIBA 3GM6A 1R2JA 2YYIA 1UDYA 4ZYJA 2REHA 2YYJA 3MXLA 3AFEA 4W9UA 2RF7A 4P13A 3X0XA 3P4TA 1FS8A 1SIRA 3MMOA 3FCJA 3F29A 2DVLA 4X28C 4ZXVA 3OWAA 2CX9A 4IV6A 1OAHA 1EGEA 3LGQA 3HWCA 3BNJA 2RFQA 4Q1OA 3D6BA 3SWOA 4NXLA 4Q5CA 2DDHA 3BNGA 4Q4UA 2OT4A 3MDDA 1EGCA 4HR3A 3TTBA 3B96A 1U8VA 3UU9A 2VR0A 2JBTA 4JEKA 3TORA 2WBIA 2JBRA 2ZO5A 4OO2A 1UKWA 5K3IA 3L1TA 3FO3A 4Q17A 2YYGA 3GNCA 4Q0TA
chains in the Genus database with same CATH superfamily
2FP2A 1WS9A 5K3HA 2BTZA 3NF4A 2OR0A 2UXWA 2F6LA 3SXQA 1IVHA 3X0YA 2E80A 4F0XA 3D9GA 1RJ1A 4LQSB 4N5FA 1FS7A 4V25A 1SIQA 1X91A 5BRMA 3C46A 2PG0A 1K93A 3Q24A 1XFUA 4MP7A 2Z1QA 3N0RA 1FS9A 2A1TA 2CJ7A 2Q8GA 3TZ2A 5M4KA 1T9GA 3EOMA 1IS2A 4MPEA 3VKHA 3Q0AA 4H81A 2AO2A 4H7QA 4KCFA 2EBFX 3X29A 4AKIA 2R0MA 3CRLA 3RKHA 2EC5A 4RM7A 3CE2A 1Y0VA 3Q22A 3BNHA 2FONA 2JIFA 4AI6A 4L1FA 2YGWA 1BUCA 3Q23A 3VKGA 2CJ5A 1R3BA 2ZAFA 3GQTA 2IX6A 1RX0A 4O5MA 1RP3A 1LVCA 4WJYA 1QDBA 3TZ5A 3UBRA 4AKGA 3MDEA 2JBSA 4KTOA 4X28A 4JIZA 5K3JA 1GU6A 1XFWA 2BU2A 4P79A 4M9AA 1W07A 4AKHA 2RDZA 4XVXA 1Y8OA 4L3XA 3VADA 2GBBA 1GKZA 3AFFA 2LFWA 3D9DA 3OWMA 4KS9A 2BU8A 4QICA 2VIGA 3PFDA 2J7AA 3BNFA 3S7WA 3DJLA 4MPNA 3MPIA 2XS1A 2YYLA 2E81A 1JM6A 4V26A 2EBAA 3MPJA 3SF6A 4G97A 2IX5A 3U33A 1GJVA 2XS8A 2R03A 2QR4A 3R7KA 2C12A 3II9A 2BU6A 5J6AA 4FF1A 2C0UA 4FZ4A 3CRKA 1XFVA 3SCEA 3LG1A 4Q5BA 4L38A 4E00A 3D9FA 3EONA 3D9EA 5K3GA 2E0AA 1S26A 2YYMA 5B5VA 2FP1A 1Y8PA 4G5EA 3D1IA 3M9VA 2XQRB 3KMLA 4L3YA 4L3ZA 4JIOA 3MKHA 2OJQA 2VF1A 4IRNA 1EGDA 1JQIA 3TZ4A 2ZDYA 5M4MA 4DOYA 4E02A 2D29A 2YYKA 2CJ8A 4U83A 2BU7A 5BRKA 2R0NA 4KSFA 3OIBA 3GM6A 2CJ4A 1X8ZA 4MPCA 4FF2A 1R2JA 1XFYA 2YYIA 1UDYA 2Q8FA 5EZ3A 4ZYJA 2R02A 2REHA 2EBHX 2Q8HA 2YYJA 1XFXA 3MXLA 3AFEA 4W9UA 2RF7A 4FF3A 4P13A 3D2RA 3X0XA 1K8TA 4FF4A 1RJ4A 3P4TA 2AZEA 1FS8A 4J1VA 1SIRA 1SC5A 1GKXA 5GJWE 3MMOA 3FCJA 1XG2B 2DVLA 4X28C 4ZXVA 1X90A 3F29A 4H85A 5B6BA 2ZKJA 5M4PA 3OWAA 4E01A 2CX9A 2R05A 4IV6A 1SK6A 1OAHA 1EGEA 3LGQA 5B5WA 3HWCA 3C2PA 3BNJA 1Y8NA 2OEVA 4LQQB 2PNRA 3TZ0A 5J71A 2RFQA 4MP2A 3D6BA 4Q1OA 3SWOA 2ZDXA 1PK0A 1PI1A 4HKSA 4NXLA 2CJ6A 4Q5CA 2DDHA 3C3LA 4DZYA 3BNGA 4KSAA 1K90A 4Q4UA 2OT4A 3MDDA 2BU5A 1EGCA 2Q8IA 4HR3A 3TTBA 5M4NA 3B96A 1U8VA 5GJVE 2OEXA 1XFZA 3UU9A 2HJNA 2PO4A 2VR0A 2JBTA 4JEKA 3TORA 2WBIA 2JBRA 2ZO5A 4HKRA 1UKWA 5K3IA 3L1TA 3FO3A 4OO2A 4Q17A 2YYGA 3GNCA 4Q0TA
chains in the Genus database with same CATH topology
1WS9A 5K3HA 3NF4A 2OR0A 2UXWA 3SXQA 1IVHA 3X0YA 2E80A 3D9GA 4N5FA 1FS7A 1SIQA 2PG0A 2Z1QA 1FS9A 2A1TA 1T9GA 3EOMA 1IS2A 4KCFA 2R0MA 3RKHA 4RM7A 3BNHA 2FONA 2JIFA 4L1FA 1BUCA 2ZAFA 3GQTA 2IX6A 1RX0A 4O5MA 4WJYA 3UBRA 1QDBA 3MDEA 2JBSA 4KTOA 4X28A 5K3JA 1GU6A 4M9AA 1W07A 2RDZA 4XVXA 4L3XA 3OWMA 3AFFA 3D9DA 3S7WA 2VIGA 3PFDA 2J7AA 3BNFA 3MPIA 2YYLA 2E81A 2EBAA 3MPJA 3SF6A 2IX5A 3R7KA 2C12A 3II9A 2C0UA 3SCEA 3LG1A 4Q5BA 4L38A 3D9FA 3EONA 3D9EA 5K3GA 2YYMA 4L3ZA 4G5EA 3D1IA 3M9VA 4L3YA 3MKHA 4IRNA 1EGDA 1JQIA 4DOYA 2D29A 2YYKA 4U83A 2R0NA 3OIBA 3GM6A 1R2JA 2YYIA 1UDYA 4ZYJA 2REHA 2YYJA 3MXLA 3AFEA 4W9UA 2RF7A 4P13A 3X0XA 3P4TA 1FS8A 1SIRA 3MMOA 3FCJA 3F29A 2DVLA 4X28C 4ZXVA 3OWAA 2CX9A 4IV6A 1OAHA 1EGEA 3LGQA 3HWCA 3BNJA 2RFQA 4Q1OA 3D6BA 3SWOA 4NXLA 4Q5CA 2DDHA 3BNGA 4Q4UA 2OT4A 3MDDA 1EGCA 4HR3A 3TTBA 3B96A 1U8VA 3UU9A 2VR0A 2JBTA 4JEKA 3TORA 2WBIA 2JBRA 2ZO5A 4OO2A 1UKWA 5K3IA 3L1TA 3FO3A 4Q17A 2YYGA 3GNCA 4Q0TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WS9 A;  5K3H A;  3NF4 A;  2OR0 A;  2UXW A;  3SXQ A;  1IVH A;  3X0Y A;  2E80 A;  3D9G A;  4N5F A;  1FS7 A;  1SIQ A;  2PG0 A;  2Z1Q A;  1FS9 A;  2A1T A;  1T9G A;  3EOM A;  1IS2 A;  4KCF A;  2R0M A;  3RKH A;  4RM7 A;  3BNH A;  2FON A;  2JIF A;  4L1F A;  1BUC A;  2ZAF A;  3GQT A;  2IX6 A;  1RX0 A;  4O5M A;  4WJY A;  3UBR A;  1QDB A;  3MDE A;  2JBS A;  4KTO A;  4X28 A;  5K3J A;  1GU6 A;  4M9A A;  1W07 A;  2RDZ A;  4XVX A;  4L3X A;  3OWM A;  3AFF A;  3D9D A;  3S7W A;  2VIG A;  3PFD A;  2J7A A;  3BNF A;  3MPI A;  2YYL A;  2E81 A;  2EBA A;  3MPJ A;  3SF6 A;  2IX5 A;  3R7K A;  2C12 A;  3II9 A;  2C0U A;  3SCE A;  3LG1 A;  4Q5B A;  4L38 A;  3D9F A;  3EON A;  3D9E A;  5K3G A;  2YYM A;  4L3Z A;  4G5E A;  3D1I A;  3M9V A;  4L3Y A;  3MKH A;  4IRN A;  1EGD A;  1JQI A;  4DOY A;  2D29 A;  2YYK A;  4U83 A;  2R0N A;  3OIB A;  3GM6 A;  1R2J A;  2YYI A;  1UDY A;  4ZYJ A;  2REH A;  2YYJ A;  3MXL A;  3AFE A;  4W9U A;  2RF7 A;  4P13 A;  3X0X A;  3P4T A;  1FS8 A;  1SIR A;  3MMO A;  3FCJ A;  3F29 A;  2DVL A;  4X28 C;  4ZXV A;  3OWA A;  2CX9 A;  4IV6 A;  1OAH A;  1EGE A;  3LGQ A;  3HWC A;  3BNJ A;  2RFQ A;  4Q1O A;  3D6B A;  3SWO A;  4NXL A;  4Q5C A;  2DDH A;  3BNG A;  4Q4U A;  2OT4 A;  3MDD A;  1EGC A;  4HR3 A;  3TTB A;  3B96 A;  1U8V A;  3UU9 A;  2VR0 A;  2JBT A;  4JEK A;  3TOR A;  2WBI A;  2JBR A;  2ZO5 A;  4OO2 A;  1UKW A;  5K3I A;  3L1T A;  3FO3 A;  4Q17 A;  2YYG A;  3GNC A;  4Q0T A; 
#chains in the Genus database with same CATH topology
 2FP2 A;  1WS9 A;  5K3H A;  2BTZ A;  3NF4 A;  2OR0 A;  2UXW A;  2F6L A;  3SXQ A;  1IVH A;  3X0Y A;  2E80 A;  4F0X A;  3D9G A;  1RJ1 A;  4LQS B;  4N5F A;  1FS7 A;  4V25 A;  1SIQ A;  1X91 A;  5BRM A;  3C46 A;  2PG0 A;  1K93 A;  3Q24 A;  1XFU A;  4MP7 A;  2Z1Q A;  3N0R A;  1FS9 A;  2A1T A;  2CJ7 A;  2Q8G A;  3TZ2 A;  5M4K A;  1T9G A;  3EOM A;  1IS2 A;  4MPE A;  3VKH A;  3Q0A A;  4H81 A;  2AO2 A;  4H7Q A;  4KCF A;  2EBF X;  3X29 A;  4AKI A;  2R0M A;  3CRL A;  3RKH A;  2EC5 A;  4RM7 A;  3CE2 A;  1Y0V A;  3Q22 A;  3BNH A;  2FON A;  2JIF A;  4AI6 A;  4L1F A;  2YGW A;  1BUC A;  3Q23 A;  3VKG A;  2CJ5 A;  1R3B A;  2ZAF A;  3GQT A;  2IX6 A;  1RX0 A;  4O5M A;  1RP3 A;  1LVC A;  4WJY A;  1QDB A;  3TZ5 A;  3UBR A;  4AKG A;  3MDE A;  2JBS A;  4KTO A;  4X28 A;  4JIZ A;  5K3J A;  1GU6 A;  1XFW A;  2BU2 A;  4P79 A;  4M9A A;  1W07 A;  4AKH A;  2RDZ A;  4XVX A;  1Y8O A;  4L3X A;  3VAD A;  2GBB A;  1GKZ A;  3AFF A;  2LFW A;  3D9D A;  3OWM A;  4KS9 A;  2BU8 A;  4QIC A;  2VIG A;  3PFD A;  2J7A A;  3BNF A;  3S7W A;  3DJL A;  4MPN A;  3MPI A;  2XS1 A;  2YYL A;  2E81 A;  1JM6 A;  4V26 A;  2EBA A;  3MPJ A;  3SF6 A;  4G97 A;  2IX5 A;  3U33 A;  1GJV A;  2XS8 A;  2R03 A;  2QR4 A;  3R7K A;  2C12 A;  3II9 A;  2BU6 A;  5J6A A;  4FF1 A;  2C0U A;  4FZ4 A;  3CRK A;  1XFV A;  3SCE A;  3LG1 A;  4Q5B A;  4L38 A;  4E00 A;  3D9F A;  3EON A;  3D9E A;  5K3G A;  2E0A A;  1S26 A;  2YYM A;  5B5V A;  2FP1 A;  1Y8P A;  4G5E A;  3D1I A;  3M9V A;  2XQR B;  3KML A;  4L3Y A;  4L3Z A;  4JIO A;  3MKH A;  2OJQ A;  2VF1 A;  4IRN A;  1EGD A;  1JQI A;  3TZ4 A;  2ZDY A;  5M4M A;  4DOY A;  4E02 A;  2D29 A;  2YYK A;  2CJ8 A;  4U83 A;  2BU7 A;  5BRK A;  2R0N A;  4KSF A;  3OIB A;  3GM6 A;  2CJ4 A;  1X8Z A;  4MPC A;  4FF2 A;  1R2J A;  1XFY A;  2YYI A;  1UDY A;  2Q8F A;  5EZ3 A;  4ZYJ A;  2R02 A;  2REH A;  2EBH X;  2Q8H A;  2YYJ A;  1XFX A;  3MXL A;  3AFE A;  4W9U A;  2RF7 A;  4FF3 A;  4P13 A;  3D2R A;  3X0X A;  1K8T A;  4FF4 A;  1RJ4 A;  3P4T A;  2AZE A;  1FS8 A;  4J1V A;  1SIR A;  1SC5 A;  1GKX A;  5GJW E;  3MMO A;  3FCJ A;  1XG2 B;  2DVL A;  4X28 C;  4ZXV A;  1X90 A;  3F29 A;  4H85 A;  5B6B A;  2ZKJ A;  5M4P A;  3OWA A;  4E01 A;  2CX9 A;  2R05 A;  4IV6 A;  1SK6 A;  1OAH A;  1EGE A;  3LGQ A;  5B5W A;  3HWC A;  3C2P A;  3BNJ A;  1Y8N A;  2OEV A;  4LQQ B;  2PNR A;  3TZ0 A;  5J71 A;  2RFQ A;  4MP2 A;  3D6B A;  4Q1O A;  3SWO A;  2ZDX A;  1PK0 A;  1PI1 A;  4HKS A;  4NXL A;  2CJ6 A;  4Q5C A;  2DDH A;  3C3L A;  4DZY A;  3BNG A;  4KSA A;  1K90 A;  4Q4U A;  2OT4 A;  3MDD A;  2BU5 A;  1EGC A;  2Q8I A;  4HR3 A;  3TTB A;  5M4N A;  3B96 A;  1U8V A;  5GJV E;  2OEX A;  1XFZ A;  3UU9 A;  2HJN A;  2PO4 A;  2VR0 A;  2JBT A;  4JEK A;  3TOR A;  2WBI A;  2JBR A;  2ZO5 A;  4HKR A;  1UKW A;  5K3I A;  3L1T A;  3FO3 A;  4OO2 A;  4Q17 A;  2YYG A;  3GNC A;  4Q0T A; 
#chains in the Genus database with same CATH homology
 1WS9 A;  5K3H A;  3NF4 A;  2OR0 A;  2UXW A;  3SXQ A;  1IVH A;  3X0Y A;  2E80 A;  3D9G A;  4N5F A;  1FS7 A;  1SIQ A;  2PG0 A;  2Z1Q A;  1FS9 A;  2A1T A;  1T9G A;  3EOM A;  1IS2 A;  4KCF A;  2R0M A;  3RKH A;  4RM7 A;  3BNH A;  2FON A;  2JIF A;  4L1F A;  1BUC A;  2ZAF A;  3GQT A;  2IX6 A;  1RX0 A;  4O5M A;  4WJY A;  3UBR A;  1QDB A;  3MDE A;  2JBS A;  4KTO A;  4X28 A;  5K3J A;  1GU6 A;  4M9A A;  1W07 A;  2RDZ A;  4XVX A;  4L3X A;  3OWM A;  3AFF A;  3D9D A;  3S7W A;  2VIG A;  3PFD A;  2J7A A;  3BNF A;  3MPI A;  2YYL A;  2E81 A;  2EBA A;  3MPJ A;  3SF6 A;  2IX5 A;  3R7K A;  2C12 A;  3II9 A;  2C0U A;  3SCE A;  3LG1 A;  4Q5B A;  4L38 A;  3D9F A;  3EON A;  3D9E A;  5K3G A;  2YYM A;  4L3Z A;  4G5E A;  3D1I A;  3M9V A;  4L3Y A;  3MKH A;  4IRN A;  1EGD A;  1JQI A;  4DOY A;  2D29 A;  2YYK A;  4U83 A;  2R0N A;  3OIB A;  3GM6 A;  1R2J A;  2YYI A;  1UDY A;  4ZYJ A;  2REH A;  2YYJ A;  3MXL A;  3AFE A;  4W9U A;  2RF7 A;  4P13 A;  3X0X A;  3P4T A;  1FS8 A;  1SIR A;  3MMO A;  3FCJ A;  3F29 A;  2DVL A;  4X28 C;  4ZXV A;  3OWA A;  2CX9 A;  4IV6 A;  1OAH A;  1EGE A;  3LGQ A;  3HWC A;  3BNJ A;  2RFQ A;  4Q1O A;  3D6B A;  3SWO A;  4NXL A;  4Q5C A;  2DDH A;  3BNG A;  4Q4U A;  2OT4 A;  3MDD A;  1EGC A;  4HR3 A;  3TTB A;  3B96 A;  1U8V A;  3UU9 A;  2VR0 A;  2JBT A;  4JEK A;  3TOR A;  2WBI A;  2JBR A;  2ZO5 A;  4OO2 A;  1UKW A;  5K3I A;  3L1T A;  3FO3 A;  4Q17 A;  2YYG A;  3GNC A;  4Q0T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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