3AFEA

Crystal structure of the hsaa monooxygenase from m.tuberculosis
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
388
structure length
384
Chain Sequence
RDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPTMV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Hydroxylase, putative
publication title A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 144
structure length 384
sequence length 388
chains with identical sequence B, C, D
ec nomenclature ec 1.14.14.12: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
pdb deposition date 2010-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08028 Acyl-CoA_dh_2 Acyl-CoA dehydrogenase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 3afeA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3afeA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 3afeA02
2JIFA 4ZYJA 3SCEA 1UDYA 3X0YA 1JQIA 4Q1OA 4WJYA 2IX6A 2UXWA 2DVLA 2E80A 4Q5CA 3R7KA 2JBRA 2J7AA 4L3ZA 3HWCA 4X28A 2ZAFA 4M9AA 3BNJA 3D9FA 3SF6A 2YYKA 3UU9A 3B96A 5K3IA 2R0MA 5K3GA 3D1IA 3MDEA 4O5MA 3FO3A 4Q4UA 3SWOA 3D9DA 3II9A 2YYIA 3F29A 2C0UA 2RFQA 2ZO5A 2RF7A 1FS8A 2E81A 4X28C 4Q0TA 2RDZA 4L1FA 1OAHA 4KTOA 4N5FA 3PFDA 3SXQA 3TTBA 4G5EA 4W9UA 3M9VA 5K3JA 3BNHA 3OIBA 2EBAA 3TORA 3GNCA 3BNGA 4NXLA 4Q17A 2C12A 2JBSA 3EONA 3MPJA 1W07A 1U8VA 2YYMA 1WS9A 2REHA 2YYJA 2YYLA 3P4TA 4HR3A 5K3HA 2Z1QA 3MPIA 2OR0A 2DDHA 3D6BA 3BNFA 3L1TA 3MMOA 2A1TA 3LG1A 1T9GA 3LGQA 4RM7A 2WBIA 2CX9A 1IS2A 3MXLA 1FS7A 4Q5BA 3GM6A 1BUCA 2OT4A 1IVHA 1GU6A 1UKWA 1FS9A 3FCJA 4ZXVA 3AFFA 4IV6A 4OO2A 4U83A 1SIRA 1SIQA 4JEKA 2R0NA 1EGDA 3UBRA 3GQTA 2VR0A 2FONA 1EGCA 3OWAA 1QDBA 3MDDA 2PG0A 3D9EA 3S7WA 4XVXA 2IX5A 2YYGA 2VIGA 3EOMA 3MKHA 2D29A 1R2JA 2JBTA 3X0XA 3D9GA 3NF4A 4DOYA 4P13A 3RKHA 1RX0A 4IRNA 4L3YA 3OWMA 3AFEA 4L3XA 1EGEA 4KCFA 4L38A
chains in the Genus database with same CATH superfamily
2XS1A 2JIFA 4ZYJA 3SCEA 1UDYA 3X0YA 3CRKA 1JQIA 4Q1OA 4WJYA 3C46A 4V25A 2IX6A 1PI1A 2UXWA 2EC5A 2DVLA 4JIOA 2E80A 4Q5CA 4H85A 4HKRA 3R7KA 2JBRA 1XFZA 3CRLA 2J7AA 2ZKJA 4L3ZA 1X8ZA 4X28A 3HWCA 3KMLA 4J1VA 4JIZA 2ZAFA 4G97A 2R05A 4AKHA 4M9AA 4FZ4A 3BNJA 3D9FA 3SF6A 2YYKA 3TZ4A 3UU9A 5J71A 2QR4A 3B96A 3X29A 4AKGA 5K3IA 2R0MA 2HJNA 1XFVA 5K3GA 5B5VA 1S26A 3D1IA 4P79A 2BU7A 3MDEA 4O5MA 3FO3A 4Q4UA 2E0AA 3DJLA 2Q8GA 3SWOA 1RJ4A 3D9DA 1XG2B 1PK0A 4HKSA 3II9A 2YYIA 5EZ3A 3F29A 1GJVA 2C0UA 2OJQA 2RFQA 2VF1A 2GBBA 2ZO5A 2RF7A 1Y8PA 5BRMA 1FS8A 3Q23A 2E81A 4X28C 2CJ8A 5J6AA 2BU2A 4Q0TA 3C2PA 2RDZA 3CE2A 4L1FA 1OAHA 5GJVE 4KTOA 2BU5A 2Q8HA 4E02A 2PO4A 4N5FA 1SC5A 3PFDA 2EBHX 2OEXA 3SXQA 3TTBA 1JM6A 1XFUA 4W9UA 4G5EA 3M9VA 4MPCA 5K3JA 3BNHA 4KS9A 3OIBA 4FF1A 4FF3A 3N0RA 3Q0AA 2EBAA 3TORA 3GNCA 2YGWA 3VKHA 4F0XA 3BNGA 2XS8A 4NXLA 4Q17A 2C12A 2JBSA 4MP7A 3EONA 3MPJA 1W07A 1RJ1A 1SK6A 2FP1A 2LFWA 2Q8IA 4AKIA 2CJ7A 3TZ5A 1Y0VA 2BU8A 3TZ0A 1U8VA 2YYMA 1WS9A 1XFWA 2REHA 3VKGA 4AI6A 2YYJA 2BTZA 4FF2A 2YYLA 3P4TA 4HR3A 2R03A 5K3HA 5M4PA 4KSAA 2Z1QA 3MPIA 2AO2A 2BU6A 2OR0A 2DDHA 3D6BA 3BNFA 3L1TA 2PNRA 2A1TA 3MMOA 4H81A 3LG1A 1T9GA 3LGQA 4MP2A 5GJWE 2Q8FA 3TZ2A 4RM7A 2WBIA 5B6BA 2CX9A 3C3LA 1IS2A 3MXLA 4LQQB 1X90A 2OEVA 1FS7A 3Q22A 4Q5BA 1Y8NA 5B5WA 3GM6A 4FF4A 1BUCA 1K90A 2OT4A 1IVHA 1GU6A 1UKWA 3VADA 1FS9A 2R02A 4E01A 4QICA 3FCJA 4ZXVA 5M4KA 3AFFA 1RP3A 1R3BA 4DZYA 2F6LA 4IV6A 4OO2A 4U83A 1SIRA 1SIQA 4JEKA 2R0NA 2CJ4A 4V26A 1EGDA 3UBRA 3GQTA 4H7QA 2VR0A 4MPNA 1X91A 1GKZA 2FONA 1XFXA 1EGCA 3OWAA 1QDBA 3MDDA 2PG0A 3D9EA 2AZEA 1Y8OA 2FP2A 3S7WA 4XVXA 2IX5A 2YYGA 5BRKA 1GKXA 2VIGA 3U33A 3EOMA 1LVCA 4E00A 3Q24A 3MKHA 2D29A 4LQSB 1R2JA 2JBTA 2CJ6A 3X0XA 2CJ5A 3D9GA 3D2RA 2ZDYA 5M4NA 4MPEA 3NF4A 2ZDXA 1XFYA 4DOYA 4P13A 4KSFA 3RKHA 1RX0A 1K93A 5M4MA 4IRNA 1K8TA 2XQRB 4L3YA 3OWMA 2EBFX 3AFEA 4L3XA 1EGEA 4KCFA 4L38A
chains in the Genus database with same CATH topology
2JIFA 4ZYJA 3SCEA 1UDYA 3X0YA 1JQIA 4Q1OA 4WJYA 2IX6A 2UXWA 2DVLA 2E80A 4Q5CA 3R7KA 2JBRA 2J7AA 4L3ZA 3HWCA 4X28A 2ZAFA 4M9AA 3BNJA 3D9FA 3SF6A 2YYKA 3UU9A 3B96A 5K3IA 2R0MA 5K3GA 3D1IA 3MDEA 4O5MA 3FO3A 4Q4UA 3SWOA 3D9DA 3II9A 2YYIA 3F29A 2C0UA 2RFQA 2ZO5A 2RF7A 1FS8A 2E81A 4X28C 4Q0TA 2RDZA 4L1FA 1OAHA 4KTOA 4N5FA 3PFDA 3SXQA 3TTBA 4G5EA 4W9UA 3M9VA 5K3JA 3BNHA 3OIBA 2EBAA 3TORA 3GNCA 3BNGA 4NXLA 4Q17A 2C12A 2JBSA 3EONA 3MPJA 1W07A 1U8VA 2YYMA 1WS9A 2REHA 2YYJA 2YYLA 3P4TA 4HR3A 5K3HA 2Z1QA 3MPIA 2OR0A 2DDHA 3D6BA 3BNFA 3L1TA 3MMOA 2A1TA 3LG1A 1T9GA 3LGQA 4RM7A 2WBIA 2CX9A 1IS2A 3MXLA 1FS7A 4Q5BA 3GM6A 1BUCA 2OT4A 1IVHA 1GU6A 1UKWA 1FS9A 3FCJA 4ZXVA 3AFFA 4IV6A 4OO2A 4U83A 1SIRA 1SIQA 4JEKA 2R0NA 1EGDA 3UBRA 3GQTA 2VR0A 2FONA 1EGCA 3OWAA 1QDBA 3MDDA 2PG0A 3D9EA 3S7WA 4XVXA 2IX5A 2YYGA 2VIGA 3EOMA 3MKHA 2D29A 1R2JA 2JBTA 3X0XA 3D9GA 3NF4A 4DOYA 4P13A 3RKHA 1RX0A 4IRNA 4L3YA 3OWMA 3AFEA 4L3XA 1EGEA 4KCFA 4L38A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JIF A;  4ZYJ A;  3SCE A;  1UDY A;  3X0Y A;  1JQI A;  4Q1O A;  4WJY A;  2IX6 A;  2UXW A;  2DVL A;  2E80 A;  4Q5C A;  3R7K A;  2JBR A;  2J7A A;  4L3Z A;  3HWC A;  4X28 A;  2ZAF A;  4M9A A;  3BNJ A;  3D9F A;  3SF6 A;  2YYK A;  3UU9 A;  3B96 A;  5K3I A;  2R0M A;  5K3G A;  3D1I A;  3MDE A;  4O5M A;  3FO3 A;  4Q4U A;  3SWO A;  3D9D A;  3II9 A;  2YYI A;  3F29 A;  2C0U A;  2RFQ A;  2ZO5 A;  2RF7 A;  1FS8 A;  2E81 A;  4X28 C;  4Q0T A;  2RDZ A;  4L1F A;  1OAH A;  4KTO A;  4N5F A;  3PFD A;  3SXQ A;  3TTB A;  4G5E A;  4W9U A;  3M9V A;  5K3J A;  3BNH A;  3OIB A;  2EBA A;  3TOR A;  3GNC A;  3BNG A;  4NXL A;  4Q17 A;  2C12 A;  2JBS A;  3EON A;  3MPJ A;  1W07 A;  1U8V A;  2YYM A;  1WS9 A;  2REH A;  2YYJ A;  2YYL A;  3P4T A;  4HR3 A;  5K3H A;  2Z1Q A;  3MPI A;  2OR0 A;  2DDH A;  3D6B A;  3BNF A;  3L1T A;  3MMO A;  2A1T A;  3LG1 A;  1T9G A;  3LGQ A;  4RM7 A;  2WBI A;  2CX9 A;  1IS2 A;  3MXL A;  1FS7 A;  4Q5B A;  3GM6 A;  1BUC A;  2OT4 A;  1IVH A;  1GU6 A;  1UKW A;  1FS9 A;  3FCJ A;  4ZXV A;  3AFF A;  4IV6 A;  4OO2 A;  4U83 A;  1SIR A;  1SIQ A;  4JEK A;  2R0N A;  1EGD A;  3UBR A;  3GQT A;  2VR0 A;  2FON A;  1EGC A;  3OWA A;  1QDB A;  3MDD A;  2PG0 A;  3D9E A;  3S7W A;  4XVX A;  2IX5 A;  2YYG A;  2VIG A;  3EOM A;  3MKH A;  2D29 A;  1R2J A;  2JBT A;  3X0X A;  3D9G A;  3NF4 A;  4DOY A;  4P13 A;  3RKH A;  1RX0 A;  4IRN A;  4L3Y A;  3OWM A;  3AFE A;  4L3X A;  1EGE A;  4KCF A;  4L38 A; 
#chains in the Genus database with same CATH topology
 2XS1 A;  2JIF A;  4ZYJ A;  3SCE A;  1UDY A;  3X0Y A;  3CRK A;  1JQI A;  4Q1O A;  4WJY A;  3C46 A;  4V25 A;  2IX6 A;  1PI1 A;  2UXW A;  2EC5 A;  2DVL A;  4JIO A;  2E80 A;  4Q5C A;  4H85 A;  4HKR A;  3R7K A;  2JBR A;  1XFZ A;  3CRL A;  2J7A A;  2ZKJ A;  4L3Z A;  1X8Z A;  4X28 A;  3HWC A;  3KML A;  4J1V A;  4JIZ A;  2ZAF A;  4G97 A;  2R05 A;  4AKH A;  4M9A A;  4FZ4 A;  3BNJ A;  3D9F A;  3SF6 A;  2YYK A;  3TZ4 A;  3UU9 A;  5J71 A;  2QR4 A;  3B96 A;  3X29 A;  4AKG A;  5K3I A;  2R0M A;  2HJN A;  1XFV A;  5K3G A;  5B5V A;  1S26 A;  3D1I A;  4P79 A;  2BU7 A;  3MDE A;  4O5M A;  3FO3 A;  4Q4U A;  2E0A A;  3DJL A;  2Q8G A;  3SWO A;  1RJ4 A;  3D9D A;  1XG2 B;  1PK0 A;  4HKS A;  3II9 A;  2YYI A;  5EZ3 A;  3F29 A;  1GJV A;  2C0U A;  2OJQ A;  2RFQ A;  2VF1 A;  2GBB A;  2ZO5 A;  2RF7 A;  1Y8P A;  5BRM A;  1FS8 A;  3Q23 A;  2E81 A;  4X28 C;  2CJ8 A;  5J6A A;  2BU2 A;  4Q0T A;  3C2P A;  2RDZ A;  3CE2 A;  4L1F A;  1OAH A;  5GJV E;  4KTO A;  2BU5 A;  2Q8H A;  4E02 A;  2PO4 A;  4N5F A;  1SC5 A;  3PFD A;  2EBH X;  2OEX A;  3SXQ A;  3TTB A;  1JM6 A;  1XFU A;  4W9U A;  4G5E A;  3M9V A;  4MPC A;  5K3J A;  3BNH A;  4KS9 A;  3OIB A;  4FF1 A;  4FF3 A;  3N0R A;  3Q0A A;  2EBA A;  3TOR A;  3GNC A;  2YGW A;  3VKH A;  4F0X A;  3BNG A;  2XS8 A;  4NXL A;  4Q17 A;  2C12 A;  2JBS A;  4MP7 A;  3EON A;  3MPJ A;  1W07 A;  1RJ1 A;  1SK6 A;  2FP1 A;  2LFW A;  2Q8I A;  4AKI A;  2CJ7 A;  3TZ5 A;  1Y0V A;  2BU8 A;  3TZ0 A;  1U8V A;  2YYM A;  1WS9 A;  1XFW A;  2REH A;  3VKG A;  4AI6 A;  2YYJ A;  2BTZ A;  4FF2 A;  2YYL A;  3P4T A;  4HR3 A;  2R03 A;  5K3H A;  5M4P A;  4KSA A;  2Z1Q A;  3MPI A;  2AO2 A;  2BU6 A;  2OR0 A;  2DDH A;  3D6B A;  3BNF A;  3L1T A;  2PNR A;  2A1T A;  3MMO A;  4H81 A;  3LG1 A;  1T9G A;  3LGQ A;  4MP2 A;  5GJW E;  2Q8F A;  3TZ2 A;  4RM7 A;  2WBI A;  5B6B A;  2CX9 A;  3C3L A;  1IS2 A;  3MXL A;  4LQQ B;  1X90 A;  2OEV A;  1FS7 A;  3Q22 A;  4Q5B A;  1Y8N A;  5B5W A;  3GM6 A;  4FF4 A;  1BUC A;  1K90 A;  2OT4 A;  1IVH A;  1GU6 A;  1UKW A;  3VAD A;  1FS9 A;  2R02 A;  4E01 A;  4QIC A;  3FCJ A;  4ZXV A;  5M4K A;  3AFF A;  1RP3 A;  1R3B A;  4DZY A;  2F6L A;  4IV6 A;  4OO2 A;  4U83 A;  1SIR A;  1SIQ A;  4JEK A;  2R0N A;  2CJ4 A;  4V26 A;  1EGD A;  3UBR A;  3GQT A;  4H7Q A;  2VR0 A;  4MPN A;  1X91 A;  1GKZ A;  2FON A;  1XFX A;  1EGC A;  3OWA A;  1QDB A;  3MDD A;  2PG0 A;  3D9E A;  2AZE A;  1Y8O A;  2FP2 A;  3S7W A;  4XVX A;  2IX5 A;  2YYG A;  5BRK A;  1GKX A;  2VIG A;  3U33 A;  3EOM A;  1LVC A;  4E00 A;  3Q24 A;  3MKH A;  2D29 A;  4LQS B;  1R2J A;  2JBT A;  2CJ6 A;  3X0X A;  2CJ5 A;  3D9G A;  3D2R A;  2ZDY A;  5M4N A;  4MPE A;  3NF4 A;  2ZDX A;  1XFY A;  4DOY A;  4P13 A;  4KSF A;  3RKH A;  1RX0 A;  1K93 A;  5M4M A;  4IRN A;  1K8T A;  2XQR B;  4L3Y A;  3OWM A;  2EBF X;  3AFE A;  4L3X A;  1EGE A;  4KCF A;  4L38 A; 
#chains in the Genus database with same CATH homology
 2JIF A;  4ZYJ A;  3SCE A;  1UDY A;  3X0Y A;  1JQI A;  4Q1O A;  4WJY A;  2IX6 A;  2UXW A;  2DVL A;  2E80 A;  4Q5C A;  3R7K A;  2JBR A;  2J7A A;  4L3Z A;  3HWC A;  4X28 A;  2ZAF A;  4M9A A;  3BNJ A;  3D9F A;  3SF6 A;  2YYK A;  3UU9 A;  3B96 A;  5K3I A;  2R0M A;  5K3G A;  3D1I A;  3MDE A;  4O5M A;  3FO3 A;  4Q4U A;  3SWO A;  3D9D A;  3II9 A;  2YYI A;  3F29 A;  2C0U A;  2RFQ A;  2ZO5 A;  2RF7 A;  1FS8 A;  2E81 A;  4X28 C;  4Q0T A;  2RDZ A;  4L1F A;  1OAH A;  4KTO A;  4N5F A;  3PFD A;  3SXQ A;  3TTB A;  4G5E A;  4W9U A;  3M9V A;  5K3J A;  3BNH A;  3OIB A;  2EBA A;  3TOR A;  3GNC A;  3BNG A;  4NXL A;  4Q17 A;  2C12 A;  2JBS A;  3EON A;  3MPJ A;  1W07 A;  1U8V A;  2YYM A;  1WS9 A;  2REH A;  2YYJ A;  2YYL A;  3P4T A;  4HR3 A;  5K3H A;  2Z1Q A;  3MPI A;  2OR0 A;  2DDH A;  3D6B A;  3BNF A;  3L1T A;  3MMO A;  2A1T A;  3LG1 A;  1T9G A;  3LGQ A;  4RM7 A;  2WBI A;  2CX9 A;  1IS2 A;  3MXL A;  1FS7 A;  4Q5B A;  3GM6 A;  1BUC A;  2OT4 A;  1IVH A;  1GU6 A;  1UKW A;  1FS9 A;  3FCJ A;  4ZXV A;  3AFF A;  4IV6 A;  4OO2 A;  4U83 A;  1SIR A;  1SIQ A;  4JEK A;  2R0N A;  1EGD A;  3UBR A;  3GQT A;  2VR0 A;  2FON A;  1EGC A;  3OWA A;  1QDB A;  3MDD A;  2PG0 A;  3D9E A;  3S7W A;  4XVX A;  2IX5 A;  2YYG A;  2VIG A;  3EOM A;  3MKH A;  2D29 A;  1R2J A;  2JBT A;  3X0X A;  3D9G A;  3NF4 A;  4DOY A;  4P13 A;  3RKH A;  1RX0 A;  4IRN A;  4L3Y A;  3OWM A;  3AFE A;  4L3X A;  1EGE A;  4KCF A;  4L38 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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