1SK6A

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin, 3',5' cyclic amp (camp), and pyrophosphate
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
507
structure length
481
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin, lyase/metal binding protein
molecule keywords Calmodulin-sensitive adenylate cyclase
publication title Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
pubmed doi rcsb
source organism Bacillus anthracis
total genus 124
structure length 481
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2004-03-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1sk6A03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1sk6A02
1YRTA 1S26A 1K90A 2COLA 1K93A 1YRUA 1SK6A 1K8TA 1XFWA 1ZOTA 1XFXA 1PK0A 1XFVA 1LVCA 1XFZA 1Y0VA 1XFYA 1XFUA
chains in the Genus database with same CATH superfamily
3B96A 3MPIA 4J1VA 5GJWE 1OAHA 3TZ4A 2IX5A 2BU2A 2YGWA 2R05A 3LG1A 3P4TA 3M9VA 1EGCA 1XFUA 1W07A 2DDHA 2VIGA 2ZO5A 2OEXA 4KS9A 3CRLA 4IRNA 4KSFA 3BNFA 2J7AA 3D1IA 5K3GA 1K8TA 4L3YA 2E80A 4MPEA 4P79A 3VKGA 3II9A 1Y0VA 2RFQA 1Y8NA 5BRKA 2JBTA 2QR4A 1RJ4A 4JEKA 2Z1QA 3TTBA 2JBSA 5J71A 1XFZA 1U8VA 3N0RA 1K93A 2F6LA 1YRUA 3X29A 2PO4A 2ZDXA 4W9UA 5B5WA 1IS2A 1PK0A 1IVHA 4H7QA 4MP7A 1ZOTA 2CX9A 1JM6A 4IV6A 4Q0TA 1S26A 2D29A 4LQSB 3GM6A 3Q22A 2CJ7A 5K3JA 1RX0A 3CRKA 2A1TA 4X28C 1XFVA 3AFEA 2REHA 3X0YA 1K90A 4DZYA 5B6BA 3FO3A 4Q1OA 1X8ZA 3R7KA 3TZ5A 3D6BA 2YYIA 4H85A 4RM7A 4HKRA 3L1TA 1Y8OA 3TORA 1FS9A 1GJVA 4E02A 2E0AA 4AKGA 2OJQA 2EBFX 3SF6A 3HWCA 3OWMA 1XFXA 2AZEA 2CJ6A 2AO2A 1LVCA 2FONA 2FP2A 1XFYA 2CJ5A 4O5MA 3UBRA 3Q24A 3SXQA 4F0XA 1QDBA 1FS7A 2R0NA 2YYLA 2ZDYA 1FS8A 4Q4UA 3Q23A 2ZKJA 3VADA 5GJVE 3RKHA 4Q17A 2VF1A 5BRMA 4ZXVA 1GU6A 1EGEA 1R3BA 4AKHA 4Q5CA 3EOMA 4L3ZA 3D9FA 2HJNA 3VKHA 2DVLA 3S7WA 2XS1A 3EONA 2VR0A 2ZAFA 2Q8GA 4LQQB 5M4MA 4X28A 2JBRA 1GKZA 2Q8IA 2WBIA 3D9EA 4KSAA 4L38A 1EGDA 1YRTA 2XQRB 2XS8A 1UDYA 2RDZA 3MDDA 4P13A 3KMLA 4HR3A 3SWOA 3Q0AA 2BU6A 1SIQA 2R03A 3AFFA 4Q5BA 5B5VA 4AI6A 2COLA 4JIOA 2R02A 1Y8PA 3GNCA 1XG2B 2C12A 2FP1A 2YYJA 3MDEA 4WJYA 3F29A 4FF4A 1X90A 2Q8HA 3SCEA 2CJ4A 3TZ2A 2C0UA 2UXWA 3C46A 2BU5A 3BNJA 3MXLA 3PFDA 2BTZA 4L1FA 4MPNA 2CJ8A 1XFWA 3GQTA 3TZ0A 4U83A 2YYGA 4JIZA 5M4PA 4XVXA 5M4NA 1RP3A 3D9GA 3BNGA 2EC5A 1SK6A 2BU7A 2PNRA 4AKIA 2R0MA 3OWAA 4E01A 4OO2A 3D9DA 4G97A 1GKXA 1X91A 2E81A 4M9AA 4MPCA 1T9GA 4MP2A 1PI1A 4HKSA 2LFWA 2GBBA 2YYKA 5J6AA 3OIBA 4G5EA 4FF3A 3X0XA 2OT4A 2IX6A 3C2PA 4H81A 3C3LA 3NF4A 1SC5A 2YYMA 4E00A 1WS9A 2BU8A 2RF7A 3UU9A 4FF2A 2OR0A 3FCJA 4KTOA 3MMOA 4QICA 5K3IA 5K3HA 1JQIA 4KCFA 1UKWA 2EBAA 2EBHX 3CE2A 1BUCA 3LGQA 4FZ4A 4N5FA 1R2JA 1SIRA 3MKHA 4V26A 4DOYA 1RJ1A 4FF1A 2JIFA 4V25A 4ZYJA 5M4KA 2PG0A 3MPJA 2OEVA 3BNHA 3D2RA 4L3XA 2Q8FA 4NXLA
chains in the Genus database with same CATH topology
1S26A 1RP3A 3Q22A 2EC5A 5GJWE 3VKHA 1SK6A 2YGWA 4AKIA 1XFVA 4G97A 1XFUA 4KS9A 4KSFA 4KSAA 1K90A 1YRTA 1K8TA 4HKSA 2LFWA 4P79A 2GBBA 3KMLA 3VKGA 3Q0AA 4FF3A 1Y0VA 4AI6A 4HKRA 3C2PA 2COLA 3C3LA 4AKGA 2FP1A 2EBFX 1SC5A 2QR4A 4FF2A 4FF4A 4QICA 1XFXA 2AZEA 2AO2A 1LVCA 1XFZA 2FP2A 1XFYA 3Q24A 2EBHX 3CE2A 3N0RA 3C46A 4AKHA 4F0XA 4FZ4A 4FF1A 1K93A 2F6LA 1YRUA 3X29A 1XFWA 2PO4A 3Q23A 5GJVE 1PK0A 1ZOTA 2VF1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YRT A;  1S26 A;  1K90 A;  2COL A;  1K93 A;  1YRU A;  1SK6 A;  1K8T A;  1XFW A;  1ZOT A;  1XFX A;  1PK0 A;  1XFV A;  1LVC A;  1XFZ A;  1Y0V A;  1XFY A;  1XFU A; 
#chains in the Genus database with same CATH topology
 3B96 A;  3MPI A;  4J1V A;  5GJW E;  1OAH A;  3TZ4 A;  2IX5 A;  2BU2 A;  2YGW A;  2R05 A;  3LG1 A;  3P4T A;  3M9V A;  1EGC A;  1XFU A;  1W07 A;  2DDH A;  2VIG A;  2ZO5 A;  2OEX A;  4KS9 A;  3CRL A;  4IRN A;  4KSF A;  3BNF A;  2J7A A;  3D1I A;  5K3G A;  1K8T A;  4L3Y A;  2E80 A;  4MPE A;  4P79 A;  3VKG A;  3II9 A;  1Y0V A;  2RFQ A;  1Y8N A;  5BRK A;  2JBT A;  2QR4 A;  1RJ4 A;  4JEK A;  2Z1Q A;  3TTB A;  2JBS A;  5J71 A;  1XFZ A;  1U8V A;  3N0R A;  1K93 A;  2F6L A;  1YRU A;  3X29 A;  2PO4 A;  2ZDX A;  4W9U A;  5B5W A;  1IS2 A;  1PK0 A;  1IVH A;  4H7Q A;  4MP7 A;  1ZOT A;  2CX9 A;  1JM6 A;  4IV6 A;  4Q0T A;  1S26 A;  2D29 A;  4LQS B;  3GM6 A;  3Q22 A;  2CJ7 A;  5K3J A;  1RX0 A;  3CRK A;  2A1T A;  4X28 C;  1XFV A;  3AFE A;  2REH A;  3X0Y A;  1K90 A;  4DZY A;  5B6B A;  3FO3 A;  4Q1O A;  1X8Z A;  3R7K A;  3TZ5 A;  3D6B A;  2YYI A;  4H85 A;  4RM7 A;  4HKR A;  3L1T A;  1Y8O A;  3TOR A;  1FS9 A;  1GJV A;  4E02 A;  2E0A A;  4AKG A;  2OJQ A;  2EBF X;  3SF6 A;  3HWC A;  3OWM A;  1XFX A;  2AZE A;  2CJ6 A;  2AO2 A;  1LVC A;  2FON A;  2FP2 A;  1XFY A;  2CJ5 A;  4O5M A;  3UBR A;  3Q24 A;  3SXQ A;  4F0X A;  1QDB A;  1FS7 A;  2R0N A;  2YYL A;  2ZDY A;  1FS8 A;  4Q4U A;  3Q23 A;  2ZKJ A;  3VAD A;  5GJV E;  3RKH A;  4Q17 A;  2VF1 A;  5BRM A;  4ZXV A;  1GU6 A;  1EGE A;  1R3B A;  4AKH A;  4Q5C A;  3EOM A;  4L3Z A;  3D9F A;  2HJN A;  3VKH A;  2DVL A;  3S7W A;  2XS1 A;  3EON A;  2VR0 A;  2ZAF A;  2Q8G A;  4LQQ B;  5M4M A;  4X28 A;  2JBR A;  1GKZ A;  2Q8I A;  2WBI A;  3D9E A;  4KSA A;  4L38 A;  1EGD A;  1YRT A;  2XQR B;  2XS8 A;  1UDY A;  2RDZ A;  3MDD A;  4P13 A;  3KML A;  4HR3 A;  3SWO A;  3Q0A A;  2BU6 A;  1SIQ A;  2R03 A;  3AFF A;  4Q5B A;  5B5V A;  4AI6 A;  2COL A;  4JIO A;  2R02 A;  1Y8P A;  3GNC A;  1XG2 B;  2C12 A;  2FP1 A;  2YYJ A;  3MDE A;  4WJY A;  3F29 A;  4FF4 A;  1X90 A;  2Q8H A;  3SCE A;  2CJ4 A;  3TZ2 A;  2C0U A;  2UXW A;  3C46 A;  2BU5 A;  3BNJ A;  3MXL A;  3PFD A;  2BTZ A;  4L1F A;  4MPN A;  2CJ8 A;  1XFW A;  3GQT A;  3TZ0 A;  4U83 A;  2YYG A;  4JIZ A;  5M4P A;  4XVX A;  5M4N A;  1RP3 A;  3D9G A;  3BNG A;  2EC5 A;  1SK6 A;  2BU7 A;  2PNR A;  4AKI A;  2R0M A;  3OWA A;  4E01 A;  4OO2 A;  3D9D A;  4G97 A;  1GKX A;  1X91 A;  2E81 A;  4M9A A;  4MPC A;  1T9G A;  4MP2 A;  1PI1 A;  4HKS A;  2LFW A;  2GBB A;  2YYK A;  5J6A A;  3OIB A;  4G5E A;  4FF3 A;  3X0X A;  2OT4 A;  2IX6 A;  3C2P A;  4H81 A;  3C3L A;  3NF4 A;  1SC5 A;  2YYM A;  4E00 A;  1WS9 A;  2BU8 A;  2RF7 A;  3UU9 A;  4FF2 A;  2OR0 A;  3FCJ A;  4KTO A;  3MMO A;  4QIC A;  5K3I A;  5K3H A;  1JQI A;  4KCF A;  1UKW A;  2EBA A;  2EBH X;  3CE2 A;  1BUC A;  3LGQ A;  4FZ4 A;  4N5F A;  1R2J A;  1SIR A;  3MKH A;  4V26 A;  4DOY A;  1RJ1 A;  4FF1 A;  2JIF A;  4V25 A;  4ZYJ A;  5M4K A;  2PG0 A;  3MPJ A;  2OEV A;  3BNH A;  3D2R A;  4L3X A;  2Q8F A;  4NXL A; 
#chains in the Genus database with same CATH homology
 1S26 A;  1RP3 A;  3Q22 A;  2EC5 A;  5GJW E;  3VKH A;  1SK6 A;  2YGW A;  4AKI A;  1XFV A;  4G97 A;  1XFU A;  4KS9 A;  4KSF A;  4KSA A;  1K90 A;  1YRT A;  1K8T A;  4HKS A;  2LFW A;  4P79 A;  2GBB A;  3KML A;  3VKG A;  3Q0A A;  4FF3 A;  1Y0V A;  4AI6 A;  4HKR A;  3C2P A;  2COL A;  3C3L A;  4AKG A;  2FP1 A;  2EBF X;  1SC5 A;  2QR4 A;  4FF2 A;  4FF4 A;  4QIC A;  1XFX A;  2AZE A;  2AO2 A;  1LVC A;  1XFZ A;  2FP2 A;  1XFY A;  3Q24 A;  2EBH X;  3CE2 A;  3N0R A;  3C46 A;  4AKH A;  4F0X A;  4FZ4 A;  4FF1 A;  1K93 A;  2F6L A;  1YRU A;  3X29 A;  1XFW A;  2PO4 A;  3Q23 A;  5GJV E;  1PK0 A;  1ZOT A;  2VF1 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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