1K93A

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
507
structure length
485
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin,lyase/metal binding protein
molecule keywords CALMODULIN-SENSITIVE ADENYLATE CYCLASE
publication title Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
pubmed doi rcsb
source organism Bacillus anthracis
total genus 141
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2001-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1k93A03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1k93A02
1SK6A 1S26A 1XFZA 1Y0VA 1K93A 1YRTA 1YRUA 1LVCA 1XFXA 1PK0A 1ZOTA 1K90A 1XFUA 2COLA 1XFWA 1XFYA 1XFVA 1K8TA
chains in the Genus database with same CATH superfamily
3OWMA 2AZEA 3Q0AA 5M4NA 2YYIA 4MP7A 3MPJA 4P79A 2PG0A 3PFDA 2JBTA 1XG2B 2EBHX 2OT4A 3X29A 4AKGA 2FP1A 2YYKA 4L1FA 3NF4A 2R0MA 3Q23A 4FF4A 3KMLA 1ZOTA 3UBRA 3TZ4A 5B6BA 2DVLA 4JIOA 2JIFA 3OWAA 2BU5A 5K3JA 2Q8HA 2BU8A 4E01A 1YRTA 4Q1OA 4DOYA 1FS9A 4MP2A 2FP2A 2CJ4A 3MMOA 1PK0A 1W07A 3D9EA 3C3LA 4G5EA 3MDDA 4V26A 4P13A 2CJ6A 1XFYA 2ZO5A 3AFEA 3EOMA 3D9FA 1X91A 3BNHA 3C2PA 1IVHA 4HR3A 1BUCA 1GU6A 4LQQB 4U83A 2XS8A 3GQTA 4ZYJA 1Y8OA 3TZ2A 5BRKA 1K8TA 2ZAFA 3D2RA 4O5MA 1Y0VA 4KSFA 3TORA 1XFXA 4AKIA 2RDZA 2EC5A 3F29A 3SWOA 3BNJA 1R2JA 2YYLA 3CRKA 4L3XA 3D9GA 2VIGA 4LQSB 3D1IA 2BU7A 5K3GA 3II9A 4Q5CA 2YYGA 2VF1A 3BNGA 3C46A 3MPIA 2ZDXA 4FF3A 4AKHA 2PNRA 1PI1A 2C0UA 4L3ZA 2Q8FA 1GKZA 3MKHA 1S26A 1EGCA 1U8VA 1K93A 2QR4A 5K3IA 5M4MA 4FF2A 2R03A 1X90A 2YGWA 2R02A 3GM6A 4KSAA 3UU9A 1SIQA 2DDHA 2OEVA 4NXLA 3VKGA 4HKSA 1RJ4A 1UKWA 4OO2A 1Y8NA 5B5WA 5M4PA 2CJ8A 1LVCA 2HJNA 5GJVE 3OIBA 4FZ4A 3LGQA 2IX5A 3TZ0A 2J7AA 3CRLA 3N0RA 4Q17A 2JBRA 2R0NA 4JIZA 4DZYA 3SF6A 4MPNA 3TTBA 1GJVA 2R05A 2JBSA 2XQRB 3L1TA 2F6LA 1FS8A 3R7KA 5B5VA 2UXWA 3CE2A 4HKRA 4MPCA 4JEKA 4W9UA 2WBIA 4H81A 5J71A 2IX6A 2E80A 2REHA 2EBAA 1GKXA 1EGDA 3RKHA 2YYJA 1YRUA 2XS1A 4X28C 3HWCA 2Q8GA 3X0XA 4H7QA 2ZDYA 2CX9A 5GJWE 4H85A 3FO3A 2OEXA 1T9GA 1EGEA 3MXLA 4L3YA 4MPEA 4QICA 5BRMA 4M9AA 1IS2A 2AO2A 2OJQA 3D6BA 1SC5A 2C12A 2CJ7A 5J6AA 4KCFA 4Q4UA 3VKHA 2GBBA 4WJYA 4X28A 5M4KA 2Q8IA 1Y8PA 1OAHA 2BU6A 3X0YA 2D29A 4Q0TA 4FF1A 2LFWA 1SIRA 4KS9A 1K90A 1UDYA 2RFQA 1RJ1A 1XFWA 2BTZA 3BNFA 1XFVA 3D9DA 3GNCA 1SK6A 4KTOA 1WS9A 1XFZA 3SXQA 1R3BA 2E81A 4L38A 3P4TA 1JM6A 3TZ5A 4E02A 4IV6A 1RX0A 1RP3A 2Z1QA 3Q22A 4Q5BA 2ZKJA 4XVXA 1XFUA 4G97A 2COLA 1X8ZA 2RF7A 3MDEA 4E00A 1QDBA 3M9VA 3VADA 2A1TA 4AI6A 1JQIA 3EONA 3AFFA 4J1VA 2VR0A 2PO4A 3SCEA 2E0AA 3B96A 3LG1A 4RM7A 4F0XA 4IRNA 4V25A 3Q24A 2FONA 4N5FA 5K3HA 4ZXVA 2BU2A 3FCJA 2CJ5A 2EBFX 1FS7A 2YYMA 3S7WA 2OR0A
chains in the Genus database with same CATH topology
2AZEA 1Y0VA 4KSFA 3Q0AA 4FF1A 1XFXA 4AKIA 2LFWA 4P79A 4KS9A 2EC5A 2F6LA 1K90A 3CE2A 4HKRA 1XFWA 3X29A 1XFVA 2EBHX 1SK6A 4AKGA 1XFZA 2FP1A 4FF4A 2VF1A 3Q23A 3KMLA 3C46A 1RP3A 1ZOTA 3Q22A 1XFUA 4G97A 2COLA 1YRTA 1S26A 2QR4A 1K93A 4FF2A 1YRUA 2FP2A 4AI6A 2YGWA 1PK0A 3C3LA 4KSAA 2PO4A 5GJWE 3VKGA 1XFYA 4F0XA 4HKSA 3Q24A 4QICA 1LVCA 3C2PA 2AO2A 4AKHA 3VKHA 1SC5A 5GJVE 4FZ4A 2EBFX 4FF3A 3N0RA 2GBBA 1K8TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SK6 A;  1S26 A;  1XFZ A;  1Y0V A;  1K93 A;  1YRT A;  1YRU A;  1LVC A;  1XFX A;  1PK0 A;  1ZOT A;  1K90 A;  1XFU A;  2COL A;  1XFW A;  1XFY A;  1XFV A;  1K8T A; 
#chains in the Genus database with same CATH topology
 3OWM A;  2AZE A;  3Q0A A;  5M4N A;  2YYI A;  4MP7 A;  3MPJ A;  4P79 A;  2PG0 A;  3PFD A;  2JBT A;  1XG2 B;  2EBH X;  2OT4 A;  3X29 A;  4AKG A;  2FP1 A;  2YYK A;  4L1F A;  3NF4 A;  2R0M A;  3Q23 A;  4FF4 A;  3KML A;  1ZOT A;  3UBR A;  3TZ4 A;  5B6B A;  2DVL A;  4JIO A;  2JIF A;  3OWA A;  2BU5 A;  5K3J A;  2Q8H A;  2BU8 A;  4E01 A;  1YRT A;  4Q1O A;  4DOY A;  1FS9 A;  4MP2 A;  2FP2 A;  2CJ4 A;  3MMO A;  1PK0 A;  1W07 A;  3D9E A;  3C3L A;  4G5E A;  3MDD A;  4V26 A;  4P13 A;  2CJ6 A;  1XFY A;  2ZO5 A;  3AFE A;  3EOM A;  3D9F A;  1X91 A;  3BNH A;  3C2P A;  1IVH A;  4HR3 A;  1BUC A;  1GU6 A;  4LQQ B;  4U83 A;  2XS8 A;  3GQT A;  4ZYJ A;  1Y8O A;  3TZ2 A;  5BRK A;  1K8T A;  2ZAF A;  3D2R A;  4O5M A;  1Y0V A;  4KSF A;  3TOR A;  1XFX A;  4AKI A;  2RDZ A;  2EC5 A;  3F29 A;  3SWO A;  3BNJ A;  1R2J A;  2YYL A;  3CRK A;  4L3X A;  3D9G A;  2VIG A;  4LQS B;  3D1I A;  2BU7 A;  5K3G A;  3II9 A;  4Q5C A;  2YYG A;  2VF1 A;  3BNG A;  3C46 A;  3MPI A;  2ZDX A;  4FF3 A;  4AKH A;  2PNR A;  1PI1 A;  2C0U A;  4L3Z A;  2Q8F A;  1GKZ A;  3MKH A;  1S26 A;  1EGC A;  1U8V A;  1K93 A;  2QR4 A;  5K3I A;  5M4M A;  4FF2 A;  2R03 A;  1X90 A;  2YGW A;  2R02 A;  3GM6 A;  4KSA A;  3UU9 A;  1SIQ A;  2DDH A;  2OEV A;  4NXL A;  3VKG A;  4HKS A;  1RJ4 A;  1UKW A;  4OO2 A;  1Y8N A;  5B5W A;  5M4P A;  2CJ8 A;  1LVC A;  2HJN A;  5GJV E;  3OIB A;  4FZ4 A;  3LGQ A;  2IX5 A;  3TZ0 A;  2J7A A;  3CRL A;  3N0R A;  4Q17 A;  2JBR A;  2R0N A;  4JIZ A;  4DZY A;  3SF6 A;  4MPN A;  3TTB A;  1GJV A;  2R05 A;  2JBS A;  2XQR B;  3L1T A;  2F6L A;  1FS8 A;  3R7K A;  5B5V A;  2UXW A;  3CE2 A;  4HKR A;  4MPC A;  4JEK A;  4W9U A;  2WBI A;  4H81 A;  5J71 A;  2IX6 A;  2E80 A;  2REH A;  2EBA A;  1GKX A;  1EGD A;  3RKH A;  2YYJ A;  1YRU A;  2XS1 A;  4X28 C;  3HWC A;  2Q8G A;  3X0X A;  4H7Q A;  2ZDY A;  2CX9 A;  5GJW E;  4H85 A;  3FO3 A;  2OEX A;  1T9G A;  1EGE A;  3MXL A;  4L3Y A;  4MPE A;  4QIC A;  5BRM A;  4M9A A;  1IS2 A;  2AO2 A;  2OJQ A;  3D6B A;  1SC5 A;  2C12 A;  2CJ7 A;  5J6A A;  4KCF A;  4Q4U A;  3VKH A;  2GBB A;  4WJY A;  4X28 A;  5M4K A;  2Q8I A;  1Y8P A;  1OAH A;  2BU6 A;  3X0Y A;  2D29 A;  4Q0T A;  4FF1 A;  2LFW A;  1SIR A;  4KS9 A;  1K90 A;  1UDY A;  2RFQ A;  1RJ1 A;  1XFW A;  2BTZ A;  3BNF A;  1XFV A;  3D9D A;  3GNC A;  1SK6 A;  4KTO A;  1WS9 A;  1XFZ A;  3SXQ A;  1R3B A;  2E81 A;  4L38 A;  3P4T A;  1JM6 A;  3TZ5 A;  4E02 A;  4IV6 A;  1RX0 A;  1RP3 A;  2Z1Q A;  3Q22 A;  4Q5B A;  2ZKJ A;  4XVX A;  1XFU A;  4G97 A;  2COL A;  1X8Z A;  2RF7 A;  3MDE A;  4E00 A;  1QDB A;  3M9V A;  3VAD A;  2A1T A;  4AI6 A;  1JQI A;  3EON A;  3AFF A;  4J1V A;  2VR0 A;  2PO4 A;  3SCE A;  2E0A A;  3B96 A;  3LG1 A;  4RM7 A;  4F0X A;  4IRN A;  4V25 A;  3Q24 A;  2FON A;  4N5F A;  5K3H A;  4ZXV A;  2BU2 A;  3FCJ A;  2CJ5 A;  2EBF X;  1FS7 A;  2YYM A;  3S7W A;  2OR0 A; 
#chains in the Genus database with same CATH homology
 2AZE A;  1Y0V A;  4KSF A;  3Q0A A;  4FF1 A;  1XFX A;  4AKI A;  2LFW A;  4P79 A;  4KS9 A;  2EC5 A;  2F6L A;  1K90 A;  3CE2 A;  4HKR A;  1XFW A;  3X29 A;  1XFV A;  2EBH X;  1SK6 A;  4AKG A;  1XFZ A;  2FP1 A;  4FF4 A;  2VF1 A;  3Q23 A;  3KML A;  3C46 A;  1RP3 A;  1ZOT A;  3Q22 A;  1XFU A;  4G97 A;  2COL A;  1YRT A;  1S26 A;  2QR4 A;  1K93 A;  4FF2 A;  1YRU A;  2FP2 A;  4AI6 A;  2YGW A;  1PK0 A;  3C3L A;  4KSA A;  2PO4 A;  5GJW E;  3VKG A;  1XFY A;  4F0X A;  4HKS A;  3Q24 A;  4QIC A;  1LVC A;  3C2P A;  2AO2 A;  4AKH A;  3VKH A;  1SC5 A;  5GJV E;  4FZ4 A;  2EBF X;  4FF3 A;  3N0R A;  2GBB A;  1K8T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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