1K93A

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
507
structure length
485
Chain Sequence
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords CALMODULIN-SENSITIVE ADENYLATE CYCLASE
publication title Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
pubmed doi rcsb
source organism Bacillus anthracis
molecule tags Toxin,lyase/metal binding protein
total genus 141
structure length 485
sequence length 507
chains with identical sequence B, C
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2001-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1k93A03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1k93A02
1K90A 1SK6A 1XFXA 1LVCA 1YRTA 1XFYA 1YRUA 2COLA 1XFUA 1S26A 1PK0A 1XFVA 1Y0VA 1K8TA 1ZOTA 1XFWA 1XFZA 1K93A
chains in the Genus database with same CATH superfamily
3MDEA 1RJ4A 1X91A 1RP3A 3X29A 1S26A 4IV6A 3EONA 1FS7A 2BTZA 3EOMA 2XS1A 1R2JA 2EBAA 1SK6A 2OEVA 1IS2A 2FP2A 1UKWA 3R7KA 2CJ7A 4RM7A 2BU5A 2RFQA 2R03A 3MDDA 2JBTA 3SF6A 4FF3A 3FO3A 3SXQA 4AKHA 1GKZA 2J7AA 1XFZA 2PG0A 5K3IA 2EBHX 2CX9A 3GNCA 3CE2A 3MXLA 3P4TA 5B5VA 3TZ0A 2Q8FA 1JM6A 1FS8A 4MPCA 2ZDXA 4MP2A 2Z1QA 2WBIA 2ZKJA 1RX0A 1SIQA 2ZO5A 3X0XA 3GQTA 1EGCA 4G97A 4NXLA 3D6BA 3Q23A 3TZ5A 3D9GA 2Q8GA 5M4NA 3S7WA 2XS8A 1GKXA 1Y8PA 3MKHA 4MP7A 2R0NA 1YRTA 1LVCA 1PI1A 4LQQB 2OR0A 4HKSA 1XFYA 4W9UA 5B5WA 2BU2A 1XFVA 2DVLA 1R3BA 4AKIA 1FS9A 2BU7A 3KMLA 3D9EA 5J71A 2YYKA 1Y8OA 4J1VA 4H7QA 4L38A 4JIZA 2Q8HA 2DDHA 4V26A 4M9AA 4KTOA 4P13A 4FF1A 4MPEA 1PK0A 4HR3A 3C46A 4L3ZA 3MPIA 2FP1A 2GBBA 4QICA 3TZ2A 2E80A 3D2RA 3F29A 5K3HA 1K93A 3HWCA 4HKRA 4L1FA 3MMOA 5GJVE 3UU9A 1XFUA 1T9GA 1ZOTA 1RJ1A 2BU8A 3AFFA 4KS9A 2VIGA 4L3YA 4Q0TA 3TTBA 3OWMA 2OT4A 3UBRA 4DZYA 3BNJA 3GM6A 4DOYA 3NF4A 3SWOA 3D9FA 2QR4A 2YYGA 1XFWA 3FCJA 3X0YA 2A1TA 1SIRA 1IVHA 2E0AA 1GJVA 1XG2B 2AZEA 2JBRA 2UXWA 4XVXA 1YRUA 5M4KA 3N0RA 1K8TA 4KSFA 4FF2A 2OEXA 3CRKA 2Q8IA 1UDYA 2HJNA 1EGEA 2E81A 3OWAA 5M4PA 4Q5BA 4KSAA 1BUCA 2JIFA 3C2PA 2AO2A 3LG1A 2LFWA 4Q17A 3VADA 3RKHA 2RF7A 2CJ8A 4O5MA 3TZ4A 4AI6A 3CRLA 1X8ZA 2YYJA 4F0XA 5M4MA 2XQRB 3VKHA 2EC5A 1K90A 3B96A 1SC5A 1Y8NA 2R02A 3OIBA 3Q24A 3MPJA 2R0MA 4H85A 2OJQA 4JIOA 2CJ4A 4Q4UA 3D1IA 2YYIA 2JBSA 4KCFA 5BRMA 1X90A 2YGWA 4H81A 3D9DA 1JQIA 4OO2A 5K3GA 4AKGA 2PNRA 2ZAFA 4ZYJA 1U8VA 4P79A 3PFDA 5GJWE 2RDZA 5BRKA 1W07A 4X28A 2BU6A 4JEKA 2IX6A 4FZ4A 3II9A 3Q0AA 2PO4A 2ZDYA 2VR0A 2C0UA 1Y0VA 4IRNA 1EGDA 4FF4A 2R05A 2VF1A 2CJ6A 4N5FA 3VKGA 4L3XA 1OAHA 1QDBA 3M9VA 3TORA 4X28C 5J6AA 3C3LA 3L1TA 4Q1OA 4V25A 2IX5A 4E02A 4WJYA 3LGQA 3SCEA 4E01A 2C12A 3BNFA 4MPNA 2FONA 1XFXA 3BNGA 3AFEA 4LQSB 2YYLA 2YYMA 4ZXVA 3Q22A 4E00A 2COLA 2CJ5A 2REHA 2F6LA 3BNHA 1GU6A 1WS9A 4G5EA 4U83A 2EBFX 4Q5CA 2D29A 5K3JA 5B6BA
chains in the Genus database with same CATH topology
2AZEA 1YRTA 1LVCA 2YGWA 4HKSA 1RP3A 1XFYA 3X29A 1YRUA 1S26A 4AKGA 1XFVA 3N0RA 4AKIA 1K8TA 4KSFA 4FF2A 4P79A 5GJWE 3KMLA 1SK6A 2FP2A 4FZ4A 3Q0AA 2PO4A 4KSAA 1PK0A 1Y0VA 3C46A 4FF3A 4QICA 2FP1A 2GBBA 4FF4A 4AKHA 2VF1A 3C2PA 2AO2A 1XFZA 1K93A 2LFWA 3VKGA 2EBHX 4HKRA 3CE2A 5GJVE 3C3LA 1XFUA 4AI6A 1ZOTA 4F0XA 4KS9A 3VKHA 2EC5A 1K90A 1XFXA 3Q22A 4G97A 1SC5A 3Q23A 3Q24A 2COLA 2F6LA 4FF1A 2QR4A 1XFWA 2EBFX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K90 A;  1SK6 A;  1XFX A;  1LVC A;  1YRT A;  1XFY A;  1YRU A;  2COL A;  1XFU A;  1S26 A;  1PK0 A;  1XFV A;  1Y0V A;  1K8T A;  1ZOT A;  1XFW A;  1XFZ A;  1K93 A; 
#chains in the Genus database with same CATH topology
 3MDE A;  1RJ4 A;  1X91 A;  1RP3 A;  3X29 A;  1S26 A;  4IV6 A;  3EON A;  1FS7 A;  2BTZ A;  3EOM A;  2XS1 A;  1R2J A;  2EBA A;  1SK6 A;  2OEV A;  1IS2 A;  2FP2 A;  1UKW A;  3R7K A;  2CJ7 A;  4RM7 A;  2BU5 A;  2RFQ A;  2R03 A;  3MDD A;  2JBT A;  3SF6 A;  4FF3 A;  3FO3 A;  3SXQ A;  4AKH A;  1GKZ A;  2J7A A;  1XFZ A;  2PG0 A;  5K3I A;  2EBH X;  2CX9 A;  3GNC A;  3CE2 A;  3MXL A;  3P4T A;  5B5V A;  3TZ0 A;  2Q8F A;  1JM6 A;  1FS8 A;  4MPC A;  2ZDX A;  4MP2 A;  2Z1Q A;  2WBI A;  2ZKJ A;  1RX0 A;  1SIQ A;  2ZO5 A;  3X0X A;  3GQT A;  1EGC A;  4G97 A;  4NXL A;  3D6B A;  3Q23 A;  3TZ5 A;  3D9G A;  2Q8G A;  5M4N A;  3S7W A;  2XS8 A;  1GKX A;  1Y8P A;  3MKH A;  4MP7 A;  2R0N A;  1YRT A;  1LVC A;  1PI1 A;  4LQQ B;  2OR0 A;  4HKS A;  1XFY A;  4W9U A;  5B5W A;  2BU2 A;  1XFV A;  2DVL A;  1R3B A;  4AKI A;  1FS9 A;  2BU7 A;  3KML A;  3D9E A;  5J71 A;  2YYK A;  1Y8O A;  4J1V A;  4H7Q A;  4L38 A;  4JIZ A;  2Q8H A;  2DDH A;  4V26 A;  4M9A A;  4KTO A;  4P13 A;  4FF1 A;  4MPE A;  1PK0 A;  4HR3 A;  3C46 A;  4L3Z A;  3MPI A;  2FP1 A;  2GBB A;  4QIC A;  3TZ2 A;  2E80 A;  3D2R A;  3F29 A;  5K3H A;  1K93 A;  3HWC A;  4HKR A;  4L1F A;  3MMO A;  5GJV E;  3UU9 A;  1XFU A;  1T9G A;  1ZOT A;  1RJ1 A;  2BU8 A;  3AFF A;  4KS9 A;  2VIG A;  4L3Y A;  4Q0T A;  3TTB A;  3OWM A;  2OT4 A;  3UBR A;  4DZY A;  3BNJ A;  3GM6 A;  4DOY A;  3NF4 A;  3SWO A;  3D9F A;  2QR4 A;  2YYG A;  1XFW A;  3FCJ A;  3X0Y A;  2A1T A;  1SIR A;  1IVH A;  2E0A A;  1GJV A;  1XG2 B;  2AZE A;  2JBR A;  2UXW A;  4XVX A;  1YRU A;  5M4K A;  3N0R A;  1K8T A;  4KSF A;  4FF2 A;  2OEX A;  3CRK A;  2Q8I A;  1UDY A;  2HJN A;  1EGE A;  2E81 A;  3OWA A;  5M4P A;  4Q5B A;  4KSA A;  1BUC A;  2JIF A;  3C2P A;  2AO2 A;  3LG1 A;  2LFW A;  4Q17 A;  3VAD A;  3RKH A;  2RF7 A;  2CJ8 A;  4O5M A;  3TZ4 A;  4AI6 A;  3CRL A;  1X8Z A;  2YYJ A;  4F0X A;  5M4M A;  2XQR B;  3VKH A;  2EC5 A;  1K90 A;  3B96 A;  1SC5 A;  1Y8N A;  2R02 A;  3OIB A;  3Q24 A;  3MPJ A;  2R0M A;  4H85 A;  2OJQ A;  4JIO A;  2CJ4 A;  4Q4U A;  3D1I A;  2YYI A;  2JBS A;  4KCF A;  5BRM A;  1X90 A;  2YGW A;  4H81 A;  3D9D A;  1JQI A;  4OO2 A;  5K3G A;  4AKG A;  2PNR A;  2ZAF A;  4ZYJ A;  1U8V A;  4P79 A;  3PFD A;  5GJW E;  2RDZ A;  5BRK A;  1W07 A;  4X28 A;  2BU6 A;  4JEK A;  2IX6 A;  4FZ4 A;  3II9 A;  3Q0A A;  2PO4 A;  2ZDY A;  2VR0 A;  2C0U A;  1Y0V A;  4IRN A;  1EGD A;  4FF4 A;  2R05 A;  2VF1 A;  2CJ6 A;  4N5F A;  3VKG A;  4L3X A;  1OAH A;  1QDB A;  3M9V A;  3TOR A;  4X28 C;  5J6A A;  3C3L A;  3L1T A;  4Q1O A;  4V25 A;  2IX5 A;  4E02 A;  4WJY A;  3LGQ A;  3SCE A;  4E01 A;  2C12 A;  3BNF A;  4MPN A;  2FON A;  1XFX A;  3BNG A;  3AFE A;  4LQS B;  2YYL A;  2YYM A;  4ZXV A;  3Q22 A;  4E00 A;  2COL A;  2CJ5 A;  2REH A;  2F6L A;  3BNH A;  1GU6 A;  1WS9 A;  4G5E A;  4U83 A;  2EBF X;  4Q5C A;  2D29 A;  5K3J A;  5B6B A; 
#chains in the Genus database with same CATH homology
 2AZE A;  1YRT A;  1LVC A;  2YGW A;  4HKS A;  1RP3 A;  1XFY A;  3X29 A;  1YRU A;  1S26 A;  4AKG A;  1XFV A;  3N0R A;  4AKI A;  1K8T A;  4KSF A;  4FF2 A;  4P79 A;  5GJW E;  3KML A;  1SK6 A;  2FP2 A;  4FZ4 A;  3Q0A A;  2PO4 A;  4KSA A;  1PK0 A;  1Y0V A;  3C46 A;  4FF3 A;  4QIC A;  2FP1 A;  2GBB A;  4FF4 A;  4AKH A;  2VF1 A;  3C2P A;  2AO2 A;  1XFZ A;  1K93 A;  2LFW A;  3VKG A;  2EBH X;  4HKR A;  3CE2 A;  5GJV E;  3C3L A;  1XFU A;  4AI6 A;  1ZOT A;  4F0X A;  4KS9 A;  3VKH A;  2EC5 A;  1K90 A;  1XFX A;  3Q22 A;  4G97 A;  1SC5 A;  3Q23 A;  3Q24 A;  2COL A;  2F6L A;  4FF1 A;  2QR4 A;  1XFW A;  2EBF X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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