3MDEA

Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate
Total Genus 150
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
150
sequence length
385
structure length
385
Chain Sequence
GFSFELTEQQKEFQATARKFAREEIIPVAAEYDRTGEYPVPLLKRAWELGLMNTHIPESFGGLGLGIIDSCLITEELAYGCTGVQTAIEANTLGQVPLIIGGNYQQQKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPASKAFTGFIVEADTPGVQIGRKEINMGQRCSDTRGIVFEDVRVPKENVLTGEGAGFKIAMGTFDKTRPPVAAGAVGLAQRALDEATKYALERKTFGKLLAEHQGISFLLADMAMKVELARLSYQRAAWEIDSGRRNTYYASIAKAYAADIANQLATDAVQVFGGNGFNTEYPVEKLMRDAKIYQIYEGTAQIQRIIIAREHIGRYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords MEDIUM CHAIN ACYL-COA DEHYDROGENASE
publication title Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.
pubmed doi rcsb
source organism Sus scrofa
total genus 150
structure length 385
sequence length 385
chains with identical sequence B
ec nomenclature ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date 1994-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 3mdeA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 3mdeA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 3mdeA02
4WJYA 3MDDA 5K3GA 2JBRA 3UBRA 3L1TA 3TTBA 1BUCA 4L3YA 1T9GA 3EOMA 4OO2A 2YYJA 4G5EA 1UDYA 3D9FA 2YYIA 3D1IA 2E80A 4X28C 3FCJA 2YYMA 1QDBA 4L3ZA 1GU6A 3RKHA 1FS7A 5K3HA 1RX0A 3P4TA 2OR0A 3SCEA 3MPJA 2JIFA 1EGCA 4M9AA 3OWAA 4IRNA 3D9EA 1W07A 4ZYJA 3HWCA 2FONA 3D6BA 1FS8A 4Q0TA 2R0MA 2EBAA 2ZAFA 2J7AA 1IVHA 3BNHA 3AFFA 3NF4A 4L1FA 2RFQA 3SXQA 1U8VA 3D9GA 2OT4A 4N5FA 2D29A 2YYKA 3MKHA 3B96A 4P13A 2JBSA 2YYGA 2JBTA 3BNGA 2YYLA 2IX6A 1EGDA 3AFEA 3TORA 2R0NA 2RDZA 2DVLA 3LGQA 3BNJA 1SIQA 4Q17A 3SWOA 4JEKA 4L38A 2C0UA 4XVXA 3X0YA 2IX5A 3UU9A 4KTOA 4DOYA 1FS9A 3PFDA 3MMOA 3GNCA 4Q5BA 2E81A 4IV6A 3D9DA 4HR3A 2A1TA 2CX9A 4Q4UA 3MDEA 4W9UA 3FO3A 3OIBA 2REHA 1UKWA 2PG0A 3S7WA 5K3JA 4X28A 2VR0A 2ZO5A 1R2JA 4NXLA 2WBIA 4L3XA 1JQIA 1OAHA 1SIRA 5K3IA 3SF6A 3BNFA 3GM6A 1IS2A 2C12A 3II9A 3M9VA 3LG1A 4ZXVA 3F29A 3GQTA 4U83A 3X0XA 2UXWA 4KCFA 3OWMA 3MXLA 2VIGA 3R7KA 4RM7A 4O5MA 3EONA 2DDHA 1EGEA 3MPIA 4Q1OA 2Z1QA 4Q5CA 1WS9A 2RF7A
chains in the Genus database with same CATH superfamily
4WJYA 5BRKA 3MDDA 5K3GA 2BU2A 1RP3A 2JBRA 3C2PA 2XS8A 3TZ0A 2VF1A 1Y0VA 3L1TA 2OEXA 2OEVA 3UBRA 1LVCA 2Q8GA 3TTBA 1BUCA 5J71A 4L3YA 1Y8PA 2AO2A 3VKGA 4E01A 1T9GA 3EOMA 4AKHA 4J1VA 4OO2A 2YYJA 1XFWA 2BU8A 2BU5A 4G5EA 1UDYA 4F0XA 3D9FA 2YYIA 3D1IA 5GJWE 3TZ4A 2E80A 2Q8IA 4X28C 5M4PA 2EBHX 3FCJA 5GJVE 2YYMA 2R05A 4H85A 2EBFX 1QDBA 4L3ZA 1GU6A 2ZKJA 3RKHA 1FS7A 1SC5A 5B6BA 5K3HA 4G97A 1RX0A 3P4TA 2OR0A 3SCEA 3Q24A 1GJVA 3MPJA 2JIFA 1EGCA 2CJ4A 4M9AA 3OWAA 1PI1A 2QR4A 4IRNA 3D9EA 1W07A 4ZYJA 3HWCA 4AI6A 1Y8OA 3CRLA 2AZEA 3KMLA 2R03A 2CJ8A 2FONA 3D6BA 1FS8A 4Q0TA 2R0MA 2EBAA 2ZAFA 2J7AA 1RJ4A 1X91A 1IVHA 3BNHA 3AFFA 4MPCA 3NF4A 3Q0AA 4L1FA 4FF3A 2RFQA 4V26A 3SXQA 1U8VA 3D9GA 4HKRA 2OT4A 4N5FA 2D29A 2GBBA 3MKHA 1PK0A 2YYKA 3B96A 4P13A 2YGWA 1XFZA 4H81A 2JBSA 4DZYA 2F6LA 5M4KA 1XFYA 4AKIA 3TZ5A 2YYGA 4AKGA 4HKSA 4LQQB 1X8ZA 2BU7A 2JBTA 3BNGA 1Y8NA 2YYLA 3C46A 2IX6A 1EGDA 2ZDYA 3Q22A 4H7QA 5M4MA 3AFEA 1K8TA 2R0NA 2RDZA 2DVLA 2HJNA 2OJQA 3LGQA 3TORA 4E02A 2Q8HA 3BNJA 5EZ3A 1SIQA 4MP2A 2E0AA 4Q17A 3SWOA 2FP2A 4JEKA 4L38A 3S7WA 5B5WA 3C3LA 3U33A 2C0UA 4XVXA 3X0YA 2IX5A 2CJ6A 4KTOA 2PO4A 3UU9A 4DOYA 4KS9A 3X29A 1FS9A 3PFDA 3MMOA 1XFVA 4V25A 2Q8FA 3GNCA 2CJ5A 4Q5BA 4QICA 2E81A 3D2RA 4JIOA 4IV6A 4LQSB 4MPEA 3D9DA 4HR3A 1GKXA 2A1TA 2LFWA 2CX9A 4Q4UA 2R02A 3MDEA 1SK6A 1XG2B 2XS1A 4MPNA 5M4NA 4W9UA 3CE2A 3FO3A 3OIBA 4KSAA 2REHA 1UKWA 2PG0A 1JM6A 2PNRA 5K3JA 4X28A 2VR0A 2XQRB 2ZO5A 1RJ1A 2ZDXA 3CRKA 1R2JA 4NXLA 3TZ2A 3VADA 2WBIA 4L3XA 4P79A 1JQIA 1K90A 1XFUA 2BU6A 1OAHA 1SIRA 5K3IA 3SF6A 1K93A 3BNFA 3GM6A 1IS2A 4KSFA 5B5VA 2C12A 3II9A 3M9VA 3LG1A 5J6AA 5BRMA 4ZXVA 3F29A 2CJ7A 4FF1A 3VKHA 3GQTA 4FF2A 4JIZA 4U83A 1R3BA 3Q23A 4FF4A 3X0XA 2UXWA 4KCFA 3OWMA 1S26A 1XFXA 3MXLA 2VIGA 3R7KA 3N0RA 4RM7A 2FP1A 4O5MA 3EONA 2DDHA 1GKZA 1EGEA 3MPIA 4FZ4A 4E00A 4Q1OA 2Z1QA 2BTZA 1X90A 2EC5A 4Q5CA 1WS9A 3DJLA 2RF7A 4MP7A
chains in the Genus database with same CATH topology
4WJYA 3MDDA 5K3GA 2JBRA 3UBRA 3L1TA 3TTBA 1BUCA 4L3YA 1T9GA 3EOMA 4OO2A 2YYJA 4G5EA 1UDYA 3D9FA 2YYIA 3D1IA 2E80A 4X28C 3FCJA 2YYMA 1QDBA 4L3ZA 1GU6A 3RKHA 1FS7A 5K3HA 1RX0A 3P4TA 2OR0A 3SCEA 3MPJA 2JIFA 1EGCA 4M9AA 3OWAA 4IRNA 3D9EA 1W07A 4ZYJA 3HWCA 2FONA 3D6BA 1FS8A 4Q0TA 2R0MA 2EBAA 2ZAFA 2J7AA 1IVHA 3BNHA 3AFFA 3NF4A 4L1FA 2RFQA 3SXQA 1U8VA 3D9GA 2OT4A 4N5FA 2D29A 2YYKA 3MKHA 3B96A 4P13A 2JBSA 2YYGA 2JBTA 3BNGA 2YYLA 2IX6A 1EGDA 3AFEA 3TORA 2R0NA 2RDZA 2DVLA 3LGQA 3BNJA 1SIQA 4Q17A 3SWOA 4JEKA 4L38A 2C0UA 4XVXA 3X0YA 2IX5A 3UU9A 4KTOA 4DOYA 1FS9A 3PFDA 3MMOA 3GNCA 4Q5BA 2E81A 4IV6A 3D9DA 4HR3A 2A1TA 2CX9A 4Q4UA 3MDEA 4W9UA 3FO3A 3OIBA 2REHA 1UKWA 2PG0A 3S7WA 5K3JA 4X28A 2VR0A 2ZO5A 1R2JA 4NXLA 2WBIA 4L3XA 1JQIA 1OAHA 1SIRA 5K3IA 3SF6A 3BNFA 3GM6A 1IS2A 2C12A 3II9A 3M9VA 3LG1A 4ZXVA 3F29A 3GQTA 4U83A 3X0XA 2UXWA 4KCFA 3OWMA 3MXLA 2VIGA 3R7KA 4RM7A 4O5MA 3EONA 2DDHA 1EGEA 3MPIA 4Q1OA 2Z1QA 4Q5CA 1WS9A 2RF7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WJY A;  3MDD A;  5K3G A;  2JBR A;  3UBR A;  3L1T A;  3TTB A;  1BUC A;  4L3Y A;  1T9G A;  3EOM A;  4OO2 A;  2YYJ A;  4G5E A;  1UDY A;  3D9F A;  2YYI A;  3D1I A;  2E80 A;  4X28 C;  3FCJ A;  2YYM A;  1QDB A;  4L3Z A;  1GU6 A;  3RKH A;  1FS7 A;  5K3H A;  1RX0 A;  3P4T A;  2OR0 A;  3SCE A;  3MPJ A;  2JIF A;  1EGC A;  4M9A A;  3OWA A;  4IRN A;  3D9E A;  1W07 A;  4ZYJ A;  3HWC A;  2FON A;  3D6B A;  1FS8 A;  4Q0T A;  2R0M A;  2EBA A;  2ZAF A;  2J7A A;  1IVH A;  3BNH A;  3AFF A;  3NF4 A;  4L1F A;  2RFQ A;  3SXQ A;  1U8V A;  3D9G A;  2OT4 A;  4N5F A;  2D29 A;  2YYK A;  3MKH A;  3B96 A;  4P13 A;  2JBS A;  2YYG A;  2JBT A;  3BNG A;  2YYL A;  2IX6 A;  1EGD A;  3AFE A;  3TOR A;  2R0N A;  2RDZ A;  2DVL A;  3LGQ A;  3BNJ A;  1SIQ A;  4Q17 A;  3SWO A;  4JEK A;  4L38 A;  2C0U A;  4XVX A;  3X0Y A;  2IX5 A;  3UU9 A;  4KTO A;  4DOY A;  1FS9 A;  3PFD A;  3MMO A;  3GNC A;  4Q5B A;  2E81 A;  4IV6 A;  3D9D A;  4HR3 A;  2A1T A;  2CX9 A;  4Q4U A;  3MDE A;  4W9U A;  3FO3 A;  3OIB A;  2REH A;  1UKW A;  2PG0 A;  3S7W A;  5K3J A;  4X28 A;  2VR0 A;  2ZO5 A;  1R2J A;  4NXL A;  2WBI A;  4L3X A;  1JQI A;  1OAH A;  1SIR A;  5K3I A;  3SF6 A;  3BNF A;  3GM6 A;  1IS2 A;  2C12 A;  3II9 A;  3M9V A;  3LG1 A;  4ZXV A;  3F29 A;  3GQT A;  4U83 A;  3X0X A;  2UXW A;  4KCF A;  3OWM A;  3MXL A;  2VIG A;  3R7K A;  4RM7 A;  4O5M A;  3EON A;  2DDH A;  1EGE A;  3MPI A;  4Q1O A;  2Z1Q A;  4Q5C A;  1WS9 A;  2RF7 A; 
#chains in the Genus database with same CATH topology
 4WJY A;  5BRK A;  3MDD A;  5K3G A;  2BU2 A;  1RP3 A;  2JBR A;  3C2P A;  2XS8 A;  3TZ0 A;  2VF1 A;  1Y0V A;  3L1T A;  2OEX A;  2OEV A;  3UBR A;  1LVC A;  2Q8G A;  3TTB A;  1BUC A;  5J71 A;  4L3Y A;  1Y8P A;  2AO2 A;  3VKG A;  4E01 A;  1T9G A;  3EOM A;  4AKH A;  4J1V A;  4OO2 A;  2YYJ A;  1XFW A;  2BU8 A;  2BU5 A;  4G5E A;  1UDY A;  4F0X A;  3D9F A;  2YYI A;  3D1I A;  5GJW E;  3TZ4 A;  2E80 A;  2Q8I A;  4X28 C;  5M4P A;  2EBH X;  3FCJ A;  5GJV E;  2YYM A;  2R05 A;  4H85 A;  2EBF X;  1QDB A;  4L3Z A;  1GU6 A;  2ZKJ A;  3RKH A;  1FS7 A;  1SC5 A;  5B6B A;  5K3H A;  4G97 A;  1RX0 A;  3P4T A;  2OR0 A;  3SCE A;  3Q24 A;  1GJV A;  3MPJ A;  2JIF A;  1EGC A;  2CJ4 A;  4M9A A;  3OWA A;  1PI1 A;  2QR4 A;  4IRN A;  3D9E A;  1W07 A;  4ZYJ A;  3HWC A;  4AI6 A;  1Y8O A;  3CRL A;  2AZE A;  3KML A;  2R03 A;  2CJ8 A;  2FON A;  3D6B A;  1FS8 A;  4Q0T A;  2R0M A;  2EBA A;  2ZAF A;  2J7A A;  1RJ4 A;  1X91 A;  1IVH A;  3BNH A;  3AFF A;  4MPC A;  3NF4 A;  3Q0A A;  4L1F A;  4FF3 A;  2RFQ A;  4V26 A;  3SXQ A;  1U8V A;  3D9G A;  4HKR A;  2OT4 A;  4N5F A;  2D29 A;  2GBB A;  3MKH A;  1PK0 A;  2YYK A;  3B96 A;  4P13 A;  2YGW A;  1XFZ A;  4H81 A;  2JBS A;  4DZY A;  2F6L A;  5M4K A;  1XFY A;  4AKI A;  3TZ5 A;  2YYG A;  4AKG A;  4HKS A;  4LQQ B;  1X8Z A;  2BU7 A;  2JBT A;  3BNG A;  1Y8N A;  2YYL A;  3C46 A;  2IX6 A;  1EGD A;  2ZDY A;  3Q22 A;  4H7Q A;  5M4M A;  3AFE A;  1K8T A;  2R0N A;  2RDZ A;  2DVL A;  2HJN A;  2OJQ A;  3LGQ A;  3TOR A;  4E02 A;  2Q8H A;  3BNJ A;  5EZ3 A;  1SIQ A;  4MP2 A;  2E0A A;  4Q17 A;  3SWO A;  2FP2 A;  4JEK A;  4L38 A;  3S7W A;  5B5W A;  3C3L A;  3U33 A;  2C0U A;  4XVX A;  3X0Y A;  2IX5 A;  2CJ6 A;  4KTO A;  2PO4 A;  3UU9 A;  4DOY A;  4KS9 A;  3X29 A;  1FS9 A;  3PFD A;  3MMO A;  1XFV A;  4V25 A;  2Q8F A;  3GNC A;  2CJ5 A;  4Q5B A;  4QIC A;  2E81 A;  3D2R A;  4JIO A;  4IV6 A;  4LQS B;  4MPE A;  3D9D A;  4HR3 A;  1GKX A;  2A1T A;  2LFW A;  2CX9 A;  4Q4U A;  2R02 A;  3MDE A;  1SK6 A;  1XG2 B;  2XS1 A;  4MPN A;  5M4N A;  4W9U A;  3CE2 A;  3FO3 A;  3OIB A;  4KSA A;  2REH A;  1UKW A;  2PG0 A;  1JM6 A;  2PNR A;  5K3J A;  4X28 A;  2VR0 A;  2XQR B;  2ZO5 A;  1RJ1 A;  2ZDX A;  3CRK A;  1R2J A;  4NXL A;  3TZ2 A;  3VAD A;  2WBI A;  4L3X A;  4P79 A;  1JQI A;  1K90 A;  1XFU A;  2BU6 A;  1OAH A;  1SIR A;  5K3I A;  3SF6 A;  1K93 A;  3BNF A;  3GM6 A;  1IS2 A;  4KSF A;  5B5V A;  2C12 A;  3II9 A;  3M9V A;  3LG1 A;  5J6A A;  5BRM A;  4ZXV A;  3F29 A;  2CJ7 A;  4FF1 A;  3VKH A;  3GQT A;  4FF2 A;  4JIZ A;  4U83 A;  1R3B A;  3Q23 A;  4FF4 A;  3X0X A;  2UXW A;  4KCF A;  3OWM A;  1S26 A;  1XFX A;  3MXL A;  2VIG A;  3R7K A;  3N0R A;  4RM7 A;  2FP1 A;  4O5M A;  3EON A;  2DDH A;  1GKZ A;  1EGE A;  3MPI A;  4FZ4 A;  4E00 A;  4Q1O A;  2Z1Q A;  2BTZ A;  1X90 A;  2EC5 A;  4Q5C A;  1WS9 A;  3DJL A;  2RF7 A;  4MP7 A; 
#chains in the Genus database with same CATH homology
 4WJY A;  3MDD A;  5K3G A;  2JBR A;  3UBR A;  3L1T A;  3TTB A;  1BUC A;  4L3Y A;  1T9G A;  3EOM A;  4OO2 A;  2YYJ A;  4G5E A;  1UDY A;  3D9F A;  2YYI A;  3D1I A;  2E80 A;  4X28 C;  3FCJ A;  2YYM A;  1QDB A;  4L3Z A;  1GU6 A;  3RKH A;  1FS7 A;  5K3H A;  1RX0 A;  3P4T A;  2OR0 A;  3SCE A;  3MPJ A;  2JIF A;  1EGC A;  4M9A A;  3OWA A;  4IRN A;  3D9E A;  1W07 A;  4ZYJ A;  3HWC A;  2FON A;  3D6B A;  1FS8 A;  4Q0T A;  2R0M A;  2EBA A;  2ZAF A;  2J7A A;  1IVH A;  3BNH A;  3AFF A;  3NF4 A;  4L1F A;  2RFQ A;  3SXQ A;  1U8V A;  3D9G A;  2OT4 A;  4N5F A;  2D29 A;  2YYK A;  3MKH A;  3B96 A;  4P13 A;  2JBS A;  2YYG A;  2JBT A;  3BNG A;  2YYL A;  2IX6 A;  1EGD A;  3AFE A;  3TOR A;  2R0N A;  2RDZ A;  2DVL A;  3LGQ A;  3BNJ A;  1SIQ A;  4Q17 A;  3SWO A;  4JEK A;  4L38 A;  2C0U A;  4XVX A;  3X0Y A;  2IX5 A;  3UU9 A;  4KTO A;  4DOY A;  1FS9 A;  3PFD A;  3MMO A;  3GNC A;  4Q5B A;  2E81 A;  4IV6 A;  3D9D A;  4HR3 A;  2A1T A;  2CX9 A;  4Q4U A;  3MDE A;  4W9U A;  3FO3 A;  3OIB A;  2REH A;  1UKW A;  2PG0 A;  3S7W A;  5K3J A;  4X28 A;  2VR0 A;  2ZO5 A;  1R2J A;  4NXL A;  2WBI A;  4L3X A;  1JQI A;  1OAH A;  1SIR A;  5K3I A;  3SF6 A;  3BNF A;  3GM6 A;  1IS2 A;  2C12 A;  3II9 A;  3M9V A;  3LG1 A;  4ZXV A;  3F29 A;  3GQT A;  4U83 A;  3X0X A;  2UXW A;  4KCF A;  3OWM A;  3MXL A;  2VIG A;  3R7K A;  4RM7 A;  4O5M A;  3EON A;  2DDH A;  1EGE A;  3MPI A;  4Q1O A;  2Z1Q A;  4Q5C A;  1WS9 A;  2RF7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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