1R2JA

Fkbi for biosynthesis of methoxymalonyl extender unit of fk520 polyketide immunosuppresant
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
363
structure length
353
Chain Sequence
ERDALLTDLVGDRAAEWDTSGELPRDLLVRLGADGLLCAEVAAEHGGLGLGSRENGEFTAHVGSLCSSLRSVMTSQGMAAWTVQRLGDAGQRATFLKELTSGLAAVGFSERQAGSDLSAMRTRVRLDGDTAVVDGHKVWTTAAAYADHLVVFGLQEDGSGAVVVVPADTPGVRVERVPKPSGCRAAGHADLHLDQVRVPAGAVLAGSGASLPMLVAASLAYGRKSVAWGCVGILRACRTAAVAHARTREQFGRPLGDHQLVAGHIADLWTAEQIAARVCEYASDHMVPATILAKHVAAERAAAGAATAAQVLASAGAGHVVERAYRDAKLMEIIEGSSEMCRVMLAQHALALP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis
pubmed doi rcsb
molecule keywords protein FkbI
molecule tags Oxidoreductase
source organism Streptomyces hygroscopicus
total genus 127
structure length 353
sequence length 363
ec nomenclature
pdb deposition date 2003-09-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1r2jA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1r2jA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1r2jA02
4L38A 1W07A 2C0UA 3F29A 3LGQA 3GM6A 2YYIA 3BNHA 3B96A 2EBAA 1SIRA 1EGDA 3HWCA 2R0NA 2D29A 3D9GA 1SIQA 3FO3A 3FCJA 3OWAA 2REHA 3OWMA 4X28A 1UDYA 3R7KA 4IV6A 4DOYA 2OR0A 3X0YA 2ZO5A 4M9AA 2VR0A 1GU6A 3MKHA 3BNFA 1IVHA 2IX6A 2YYGA 3GQTA 4O5MA 1EGEA 4NXLA 2DVLA 4ZXVA 3AFEA 3BNGA 4Q1OA 2C12A 3SXQA 3TORA 3II9A 3D9FA 4N5FA 4P13A 3MPJA 3TTBA 1FS7A 4L1FA 1UKWA 3SCEA 2RFQA 3PFDA 4OO2A 1RX0A 3MDEA 3EONA 2R0MA 2E81A 3MMOA 3X0XA 2A1TA 3LG1A 3OIBA 1R2JA 1BUCA 4IRNA 3GNCA 2JBRA 4RM7A 3EOMA 4Q5CA 3MXLA 1IS2A 2UXWA 2OT4A 4KCFA 3M9VA 4WJYA 3NF4A 2YYLA 4KTOA 1T9GA 4W9UA 4U83A 2E80A 3AFFA 3SWOA 4Q5BA 5K3HA 1OAHA 2YYMA 1EGCA 4L3XA 4Q0TA 3UBRA 2PG0A 3UU9A 2VIGA 4Q17A 2J7AA 4X28C 2YYJA 4Q4UA 4L3YA 3L1TA 3S7WA 2CX9A 1U8VA 3RKHA 3BNJA 4ZYJA 5K3GA 3D9EA 4L3ZA 2YYKA 2FONA 1JQIA 5K3IA 2Z1QA 2JIFA 3MDDA 3P4TA 2JBSA 4JEKA 2WBIA 1FS8A 4HR3A 2JBTA 2RF7A 4XVXA 3D9DA 1QDBA 3D1IA 3D6BA 3SF6A 3MPIA 2IX5A 2RDZA 4G5EA 2ZAFA 1WS9A 1FS9A 5K3JA 2DDHA
chains in the Genus database with same CATH superfamily
4L38A 1XFVA 1W07A 2C0UA 3F29A 3LGQA 3GM6A 2YYIA 1XFXA 1PI1A 2XQRB 2Q8HA 2LFWA 1Y8NA 1PK0A 2AO2A 2VF1A 3BNHA 4G97A 3B96A 3TZ5A 2EBAA 1SIRA 1EGDA 2FP1A 3HWCA 2R0NA 5GJWE 2D29A 3D9GA 4KSFA 2BTZA 1SIQA 1XFYA 3DJLA 3C3LA 4FF1A 1SK6A 3FO3A 4AKHA 3FCJA 3VKGA 3OWAA 2OEXA 3U33A 2REHA 3OWMA 4X28A 1UDYA 3R7KA 4IV6A 2R03A 4DOYA 4E01A 2OR0A 2ZDYA 3X0YA 2ZDXA 5M4NA 3C46A 5M4PA 2EBHX 2HJNA 2ZO5A 2QR4A 4M9AA 2VR0A 1GU6A 4MP7A 2CJ8A 3CE2A 1GKZA 2PO4A 3MKHA 2F6LA 2CJ6A 2R02A 2BU6A 3BNFA 1IVHA 2IX6A 2E0AA 3TZ0A 4FF4A 2YYGA 3GQTA 1X91A 4LQSB 4O5MA 1SC5A 3Q22A 1EGEA 4NXLA 2CJ5A 1K90A 5B5WA 2DVLA 4ZXVA 2R05A 3AFEA 1X8ZA 3BNGA 2OEVA 1XFZA 4Q1OA 2C12A 3SXQA 3TORA 5J6AA 3Q0AA 5BRMA 3II9A 3D9FA 4N5FA 4P13A 4V25A 4AKIA 4MPCA 1Y0VA 2BU7A 3MPJA 3TTBA 1FS7A 3X29A 5M4KA 4L1FA 3VKHA 1UKWA 3SCEA 2RFQA 2BU5A 1GKXA 3PFDA 4HKRA 3TZ2A 4F0XA 5EZ3A 4OO2A 1RX0A 3C2PA 3MDEA 2Q8IA 4DZYA 3EONA 1GJVA 2R0MA 2E81A 3KMLA 3MMOA 4JIOA 3X0XA 2A1TA 3LG1A 3OIBA 1R2JA 2EC5A 4H7QA 1BUCA 3CRKA 5BRKA 5M4MA 4IRNA 4P79A 3GNCA 2JBRA 4RM7A 3EOMA 3CRLA 4Q5CA 1RJ1A 2OJQA 3MXLA 3Q23A 1IS2A 2UXWA 2OT4A 3N0RA 4KCFA 3M9VA 2ZKJA 4FF2A 4WJYA 2FP2A 3NF4A 2YYLA 4KTOA 4V26A 1T9GA 2YGWA 4W9UA 4H85A 4U83A 2E80A 2Q8GA 3AFFA 3SWOA 4MP2A 4Q5BA 5K3HA 1OAHA 4HKSA 4E02A 2YYMA 1EGCA 4L3XA 4Q0TA 3VADA 1XFWA 3UBRA 3TZ4A 2PG0A 1X90A 4MPEA 1XFUA 5B5VA 2VIGA 2XS1A 3UU9A 4Q17A 2J7AA 2GBBA 1RJ4A 4X28C 1LVCA 1XG2B 2BU2A 2YYJA 4Q4UA 1S26A 4L3YA 3L1TA 3S7WA 2CX9A 1U8VA 4MPNA 3RKHA 3BNJA 5B6BA 4FF3A 4AKGA 4ZYJA 5K3GA 1K93A 3D9EA 1Y8OA 4JIZA 4L3ZA 2YYKA 2Q8FA 5GJVE 1Y8PA 1K8TA 1JM6A 2FONA 1JQIA 5K3IA 4FZ4A 2Z1QA 2JIFA 3MDDA 3P4TA 2AZEA 1R3BA 2BU8A 2JBSA 4JEKA 4LQQB 2CJ4A 4J1VA 2WBIA 1FS8A 4HR3A 4QICA 2JBTA 2RF7A 4H81A 4E00A 4XVXA 3D9DA 1QDBA 3D2RA 4AI6A 2PNRA 2XS8A 2CJ7A 3D1IA 2EBFX 3D6BA 3SF6A 3MPIA 4KSAA 3Q24A 2IX5A 2RDZA 4G5EA 4KS9A 2ZAFA 1WS9A 1FS9A 5J71A 5K3JA 1RP3A 2DDHA
chains in the Genus database with same CATH topology
4L38A 1W07A 2C0UA 3F29A 3LGQA 3GM6A 2YYIA 3BNHA 3B96A 2EBAA 1SIRA 1EGDA 3HWCA 2R0NA 2D29A 3D9GA 1SIQA 3FO3A 3FCJA 3OWAA 2REHA 3OWMA 4X28A 1UDYA 3R7KA 4IV6A 4DOYA 2OR0A 3X0YA 2ZO5A 4M9AA 2VR0A 1GU6A 3MKHA 3BNFA 1IVHA 2IX6A 2YYGA 3GQTA 4O5MA 1EGEA 4NXLA 2DVLA 4ZXVA 3AFEA 3BNGA 4Q1OA 2C12A 3SXQA 3TORA 3II9A 3D9FA 4N5FA 4P13A 3MPJA 3TTBA 1FS7A 4L1FA 1UKWA 3SCEA 2RFQA 3PFDA 4OO2A 1RX0A 3MDEA 3EONA 2R0MA 2E81A 3MMOA 3X0XA 2A1TA 3LG1A 3OIBA 1R2JA 1BUCA 4IRNA 3GNCA 2JBRA 4RM7A 3EOMA 4Q5CA 3MXLA 1IS2A 2UXWA 2OT4A 4KCFA 3M9VA 4WJYA 3NF4A 2YYLA 4KTOA 1T9GA 4W9UA 4U83A 2E80A 3AFFA 3SWOA 4Q5BA 5K3HA 1OAHA 2YYMA 1EGCA 4L3XA 4Q0TA 3UBRA 2PG0A 3UU9A 2VIGA 4Q17A 2J7AA 4X28C 2YYJA 4Q4UA 4L3YA 3L1TA 3S7WA 2CX9A 1U8VA 3RKHA 3BNJA 4ZYJA 5K3GA 3D9EA 4L3ZA 2YYKA 2FONA 1JQIA 5K3IA 2Z1QA 2JIFA 3MDDA 3P4TA 2JBSA 4JEKA 2WBIA 1FS8A 4HR3A 2JBTA 2RF7A 4XVXA 3D9DA 1QDBA 3D1IA 3D6BA 3SF6A 3MPIA 2IX5A 2RDZA 4G5EA 2ZAFA 1WS9A 1FS9A 5K3JA 2DDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L38 A;  1W07 A;  2C0U A;  3F29 A;  3LGQ A;  3GM6 A;  2YYI A;  3BNH A;  3B96 A;  2EBA A;  1SIR A;  1EGD A;  3HWC A;  2R0N A;  2D29 A;  3D9G A;  1SIQ A;  3FO3 A;  3FCJ A;  3OWA A;  2REH A;  3OWM A;  4X28 A;  1UDY A;  3R7K A;  4IV6 A;  4DOY A;  2OR0 A;  3X0Y A;  2ZO5 A;  4M9A A;  2VR0 A;  1GU6 A;  3MKH A;  3BNF A;  1IVH A;  2IX6 A;  2YYG A;  3GQT A;  4O5M A;  1EGE A;  4NXL A;  2DVL A;  4ZXV A;  3AFE A;  3BNG A;  4Q1O A;  2C12 A;  3SXQ A;  3TOR A;  3II9 A;  3D9F A;  4N5F A;  4P13 A;  3MPJ A;  3TTB A;  1FS7 A;  4L1F A;  1UKW A;  3SCE A;  2RFQ A;  3PFD A;  4OO2 A;  1RX0 A;  3MDE A;  3EON A;  2R0M A;  2E81 A;  3MMO A;  3X0X A;  2A1T A;  3LG1 A;  3OIB A;  1R2J A;  1BUC A;  4IRN A;  3GNC A;  2JBR A;  4RM7 A;  3EOM A;  4Q5C A;  3MXL A;  1IS2 A;  2UXW A;  2OT4 A;  4KCF A;  3M9V A;  4WJY A;  3NF4 A;  2YYL A;  4KTO A;  1T9G A;  4W9U A;  4U83 A;  2E80 A;  3AFF A;  3SWO A;  4Q5B A;  5K3H A;  1OAH A;  2YYM A;  1EGC A;  4L3X A;  4Q0T A;  3UBR A;  2PG0 A;  3UU9 A;  2VIG A;  4Q17 A;  2J7A A;  4X28 C;  2YYJ A;  4Q4U A;  4L3Y A;  3L1T A;  3S7W A;  2CX9 A;  1U8V A;  3RKH A;  3BNJ A;  4ZYJ A;  5K3G A;  3D9E A;  4L3Z A;  2YYK A;  2FON A;  1JQI A;  5K3I A;  2Z1Q A;  2JIF A;  3MDD A;  3P4T A;  2JBS A;  4JEK A;  2WBI A;  1FS8 A;  4HR3 A;  2JBT A;  2RF7 A;  4XVX A;  3D9D A;  1QDB A;  3D1I A;  3D6B A;  3SF6 A;  3MPI A;  2IX5 A;  2RDZ A;  4G5E A;  2ZAF A;  1WS9 A;  1FS9 A;  5K3J A;  2DDH A; 
#chains in the Genus database with same CATH topology
 4L38 A;  1XFV A;  1W07 A;  2C0U A;  3F29 A;  3LGQ A;  3GM6 A;  2YYI A;  1XFX A;  1PI1 A;  2XQR B;  2Q8H A;  2LFW A;  1Y8N A;  1PK0 A;  2AO2 A;  2VF1 A;  3BNH A;  4G97 A;  3B96 A;  3TZ5 A;  2EBA A;  1SIR A;  1EGD A;  2FP1 A;  3HWC A;  2R0N A;  5GJW E;  2D29 A;  3D9G A;  4KSF A;  2BTZ A;  1SIQ A;  1XFY A;  3DJL A;  3C3L A;  4FF1 A;  1SK6 A;  3FO3 A;  4AKH A;  3FCJ A;  3VKG A;  3OWA A;  2OEX A;  3U33 A;  2REH A;  3OWM A;  4X28 A;  1UDY A;  3R7K A;  4IV6 A;  2R03 A;  4DOY A;  4E01 A;  2OR0 A;  2ZDY A;  3X0Y A;  2ZDX A;  5M4N A;  3C46 A;  5M4P A;  2EBH X;  2HJN A;  2ZO5 A;  2QR4 A;  4M9A A;  2VR0 A;  1GU6 A;  4MP7 A;  2CJ8 A;  3CE2 A;  1GKZ A;  2PO4 A;  3MKH A;  2F6L A;  2CJ6 A;  2R02 A;  2BU6 A;  3BNF A;  1IVH A;  2IX6 A;  2E0A A;  3TZ0 A;  4FF4 A;  2YYG A;  3GQT A;  1X91 A;  4LQS B;  4O5M A;  1SC5 A;  3Q22 A;  1EGE A;  4NXL A;  2CJ5 A;  1K90 A;  5B5W A;  2DVL A;  4ZXV A;  2R05 A;  3AFE A;  1X8Z A;  3BNG A;  2OEV A;  1XFZ A;  4Q1O A;  2C12 A;  3SXQ A;  3TOR A;  5J6A A;  3Q0A A;  5BRM A;  3II9 A;  3D9F A;  4N5F A;  4P13 A;  4V25 A;  4AKI A;  4MPC A;  1Y0V A;  2BU7 A;  3MPJ A;  3TTB A;  1FS7 A;  3X29 A;  5M4K A;  4L1F A;  3VKH A;  1UKW A;  3SCE A;  2RFQ A;  2BU5 A;  1GKX A;  3PFD A;  4HKR A;  3TZ2 A;  4F0X A;  5EZ3 A;  4OO2 A;  1RX0 A;  3C2P A;  3MDE A;  2Q8I A;  4DZY A;  3EON A;  1GJV A;  2R0M A;  2E81 A;  3KML A;  3MMO A;  4JIO A;  3X0X A;  2A1T A;  3LG1 A;  3OIB A;  1R2J A;  2EC5 A;  4H7Q A;  1BUC A;  3CRK A;  5BRK A;  5M4M A;  4IRN A;  4P79 A;  3GNC A;  2JBR A;  4RM7 A;  3EOM A;  3CRL A;  4Q5C A;  1RJ1 A;  2OJQ A;  3MXL A;  3Q23 A;  1IS2 A;  2UXW A;  2OT4 A;  3N0R A;  4KCF A;  3M9V A;  2ZKJ A;  4FF2 A;  4WJY A;  2FP2 A;  3NF4 A;  2YYL A;  4KTO A;  4V26 A;  1T9G A;  2YGW A;  4W9U A;  4H85 A;  4U83 A;  2E80 A;  2Q8G A;  3AFF A;  3SWO A;  4MP2 A;  4Q5B A;  5K3H A;  1OAH A;  4HKS A;  4E02 A;  2YYM A;  1EGC A;  4L3X A;  4Q0T A;  3VAD A;  1XFW A;  3UBR A;  3TZ4 A;  2PG0 A;  1X90 A;  4MPE A;  1XFU A;  5B5V A;  2VIG A;  2XS1 A;  3UU9 A;  4Q17 A;  2J7A A;  2GBB A;  1RJ4 A;  4X28 C;  1LVC A;  1XG2 B;  2BU2 A;  2YYJ A;  4Q4U A;  1S26 A;  4L3Y A;  3L1T A;  3S7W A;  2CX9 A;  1U8V A;  4MPN A;  3RKH A;  3BNJ A;  5B6B A;  4FF3 A;  4AKG A;  4ZYJ A;  5K3G A;  1K93 A;  3D9E A;  1Y8O A;  4JIZ A;  4L3Z A;  2YYK A;  2Q8F A;  5GJV E;  1Y8P A;  1K8T A;  1JM6 A;  2FON A;  1JQI A;  5K3I A;  4FZ4 A;  2Z1Q A;  2JIF A;  3MDD A;  3P4T A;  2AZE A;  1R3B A;  2BU8 A;  2JBS A;  4JEK A;  4LQQ B;  2CJ4 A;  4J1V A;  2WBI A;  1FS8 A;  4HR3 A;  4QIC A;  2JBT A;  2RF7 A;  4H81 A;  4E00 A;  4XVX A;  3D9D A;  1QDB A;  3D2R A;  4AI6 A;  2PNR A;  2XS8 A;  2CJ7 A;  3D1I A;  2EBF X;  3D6B A;  3SF6 A;  3MPI A;  4KSA A;  3Q24 A;  2IX5 A;  2RDZ A;  4G5E A;  4KS9 A;  2ZAF A;  1WS9 A;  1FS9 A;  5J71 A;  5K3J A;  1RP3 A;  2DDH A; 
#chains in the Genus database with same CATH homology
 4L38 A;  1W07 A;  2C0U A;  3F29 A;  3LGQ A;  3GM6 A;  2YYI A;  3BNH A;  3B96 A;  2EBA A;  1SIR A;  1EGD A;  3HWC A;  2R0N A;  2D29 A;  3D9G A;  1SIQ A;  3FO3 A;  3FCJ A;  3OWA A;  2REH A;  3OWM A;  4X28 A;  1UDY A;  3R7K A;  4IV6 A;  4DOY A;  2OR0 A;  3X0Y A;  2ZO5 A;  4M9A A;  2VR0 A;  1GU6 A;  3MKH A;  3BNF A;  1IVH A;  2IX6 A;  2YYG A;  3GQT A;  4O5M A;  1EGE A;  4NXL A;  2DVL A;  4ZXV A;  3AFE A;  3BNG A;  4Q1O A;  2C12 A;  3SXQ A;  3TOR A;  3II9 A;  3D9F A;  4N5F A;  4P13 A;  3MPJ A;  3TTB A;  1FS7 A;  4L1F A;  1UKW A;  3SCE A;  2RFQ A;  3PFD A;  4OO2 A;  1RX0 A;  3MDE A;  3EON A;  2R0M A;  2E81 A;  3MMO A;  3X0X A;  2A1T A;  3LG1 A;  3OIB A;  1R2J A;  1BUC A;  4IRN A;  3GNC A;  2JBR A;  4RM7 A;  3EOM A;  4Q5C A;  3MXL A;  1IS2 A;  2UXW A;  2OT4 A;  4KCF A;  3M9V A;  4WJY A;  3NF4 A;  2YYL A;  4KTO A;  1T9G A;  4W9U A;  4U83 A;  2E80 A;  3AFF A;  3SWO A;  4Q5B A;  5K3H A;  1OAH A;  2YYM A;  1EGC A;  4L3X A;  4Q0T A;  3UBR A;  2PG0 A;  3UU9 A;  2VIG A;  4Q17 A;  2J7A A;  4X28 C;  2YYJ A;  4Q4U A;  4L3Y A;  3L1T A;  3S7W A;  2CX9 A;  1U8V A;  3RKH A;  3BNJ A;  4ZYJ A;  5K3G A;  3D9E A;  4L3Z A;  2YYK A;  2FON A;  1JQI A;  5K3I A;  2Z1Q A;  2JIF A;  3MDD A;  3P4T A;  2JBS A;  4JEK A;  2WBI A;  1FS8 A;  4HR3 A;  2JBT A;  2RF7 A;  4XVX A;  3D9D A;  1QDB A;  3D1I A;  3D6B A;  3SF6 A;  3MPI A;  2IX5 A;  2RDZ A;  4G5E A;  2ZAF A;  1WS9 A;  1FS9 A;  5K3J A;  2DDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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