2R0MA

The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate
Total Genus 155
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
390
structure length
390
Chain Sequence
EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYDGTHDIHALILGRAITGIQAFTA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Oxidoreductase
molecule keywords Glutaryl-CoA dehydrogenase
publication title The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate.
pubmed doi rcsb
source organism Homo sapiens
total genus 155
structure length 390
sequence length 390
ec nomenclature ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date 2007-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 2r0mA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 2r0mA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 2r0mA02
3LG1A 1IVHA 3AFEA 3OWMA 1FS7A 2RDZA 1GU6A 2C12A 2J7AA 3MPJA 3OIBA 4DOYA 4L1FA 1BUCA 3B96A 1UDYA 2RFQA 3FCJA 3EONA 5K3GA 2JBTA 2OT4A 3MXLA 4N5FA 4XVXA 4OO2A 3RKHA 4KTOA 3OWAA 3R7KA 4ZYJA 3SF6A 3BNJA 2DDHA 4L3ZA 1FS8A 2YYJA 1W07A 3GQTA 4NXLA 3X0YA 3D9DA 1U8VA 3EOMA 3D9EA 3MKHA 3BNFA 3TTBA 2IX5A 3F29A 4M9AA 2EBAA 1R2JA 2JBSA 3D6BA 3D9FA 4RM7A 3D9GA 2YYLA 3MMOA 4Q0TA 4ZXVA 3GNCA 4L38A 4Q17A 2E80A 2WBIA 3BNHA 2Z1QA 3SWOA 1WS9A 4KCFA 3MDDA 3II9A 3TORA 3MDEA 4Q1OA 2UXWA 3LGQA 3UBRA 3BNGA 2JBRA 3P4TA 4IRNA 3AFFA 2DVLA 3MPIA 3HWCA 3M9VA 1EGEA 2YYMA 1T9GA 2ZAFA 2R0NA 4L3XA 3SXQA 1FS9A 3S7WA 5K3JA 4L3YA 4X28C 4Q5CA 3SCEA 2A1TA 4G5EA 2IX6A 4P13A 2YYIA 1IS2A 3D1IA 2RF7A 2FONA 2YYKA 1EGCA 1SIQA 1QDBA 4W9UA 2JIFA 4O5MA 3L1TA 2VR0A 4WJYA 4IV6A 2YYGA 2ZO5A 2PG0A 4Q5BA 1EGDA 2D29A 3NF4A 2C0UA 3PFDA 1SIRA 5K3IA 1OAHA 4JEKA 5K3HA 1JQIA 2VIGA 3FO3A 1RX0A 3UU9A 2CX9A 3X0XA 3GM6A 2REHA 2R0MA 4Q4UA 4HR3A 4U83A 1UKWA 2OR0A 4X28A 2E81A
chains in the Genus database with same CATH superfamily
3LG1A 1IVHA 3AFEA 3TZ5A 2EBHX 3CRLA 2ZDXA 1FS7A 2PO4A 2RDZA 3OWMA 3Q0AA 1GU6A 2C12A 2J7AA 3MPJA 1GKZA 2R03A 3OIBA 4DOYA 4L1FA 1Y8PA 4AI6A 2BU6A 3U33A 1BUCA 3B96A 1UDYA 1XG2B 2LFWA 2RFQA 3FCJA 3EONA 5K3GA 4LQQB 2CJ6A 4HKSA 4JIZA 1Y8OA 2YGWA 2JBTA 1XFYA 4V26A 2OT4A 3MXLA 4N5FA 4XVXA 3KMLA 4OO2A 3RKHA 5M4MA 4KTOA 3OWAA 5GJVE 2GBBA 1RJ4A 5BRMA 3R7KA 4ZYJA 2QR4A 2Q8FA 4F0XA 3SF6A 4DZYA 5GJWE 3BNJA 2DDHA 4L3ZA 3D2RA 1S26A 1FS8A 2YYJA 3N0RA 1W07A 4G97A 3GQTA 5J6AA 3Q22A 4NXLA 1XFWA 2R02A 3C3LA 4FF3A 5B6BA 3X0YA 3D9DA 1U8VA 2BU5A 3EOMA 4P79A 5EZ3A 3D9EA 4H7QA 3MKHA 3BNFA 3TTBA 2IX5A 2CJ5A 4J1VA 3F29A 4FZ4A 4M9AA 2EBAA 1R2JA 2JBSA 3D6BA 3D9FA 4RM7A 3D9GA 2XQRB 2YYLA 4KSFA 4V25A 3DJLA 2AZEA 3MMOA 4Q0TA 4MPCA 4ZXVA 3GNCA 4L38A 4Q17A 2CJ8A 2E80A 2WBIA 2BTZA 3BNHA 2Z1QA 3SWOA 1WS9A 4KCFA 1K8TA 2ZKJA 3MDDA 3II9A 1RJ1A 2BU2A 3TORA 3MDEA 1PI1A 3VADA 4FF1A 3VKHA 4Q1OA 2UXWA 3LGQA 3UBRA 2R05A 1XFXA 2XS8A 3BNGA 2JBRA 2HJNA 3P4TA 4IRNA 2CJ7A 2ZDYA 3AFFA 1X91A 5M4KA 4MPNA 2DVLA 3MPIA 4KS9A 3HWCA 2AO2A 3M9VA 1K93A 1EGEA 2YYMA 4FF2A 1T9GA 2ZAFA 5B5WA 2R0NA 4L3XA 1X90A 3SXQA 1FS9A 5BRKA 3X29A 3S7WA 5M4NA 4LQSB 4QICA 1GKXA 5K3JA 1Y8NA 4L3YA 2Q8IA 5M4PA 3C46A 1SK6A 1XFZA 4X28C 1XFUA 2OJQA 3CE2A 4Q5CA 2A1TA 3SCEA 1SC5A 2E0AA 3TZ4A 4AKGA 4G5EA 4MPEA 2IX6A 2EC5A 4P13A 1PK0A 2YYIA 3CRKA 1IS2A 3D1IA 3VKGA 2RF7A 2FONA 4HKRA 1JM6A 3Q24A 2BU8A 4E02A 2YYKA 1XFVA 1EGCA 3Q23A 1SIQA 4MP2A 1QDBA 4W9UA 1X8ZA 4FF4A 4H81A 1RP3A 2JIFA 4O5MA 3L1TA 4JIOA 4MP7A 2VR0A 3TZ0A 4WJYA 4IV6A 2YYGA 2ZO5A 4KSAA 2PG0A 4Q5BA 2BU7A 3TZ2A 4E00A 1EGDA 2XS1A 2VF1A 1GJVA 2D29A 3NF4A 2C0UA 2FP1A 4E01A 3PFDA 2CJ4A 1SIRA 5K3IA 1OAHA 4AKIA 4JEKA 5K3HA 1JQIA 4AKHA 2VIGA 2F6LA 1R3BA 2PNRA 3FO3A 1RX0A 2EBFX 3UU9A 2CX9A 3X0XA 1K90A 2FP2A 4H85A 3GM6A 2Q8HA 5J71A 1LVCA 2OEXA 2REHA 2Q8GA 2R0MA 5B5VA 4Q4UA 4HR3A 4U83A 1Y0VA 1UKWA 2OR0A 2OEVA 3C2PA 4X28A 2E81A
chains in the Genus database with same CATH topology
3LG1A 1IVHA 3AFEA 3OWMA 1FS7A 2RDZA 1GU6A 2C12A 2J7AA 3MPJA 3OIBA 4DOYA 4L1FA 1BUCA 3B96A 1UDYA 2RFQA 3FCJA 3EONA 5K3GA 2JBTA 2OT4A 3MXLA 4N5FA 4XVXA 4OO2A 3RKHA 4KTOA 3OWAA 3R7KA 4ZYJA 3SF6A 3BNJA 2DDHA 4L3ZA 1FS8A 2YYJA 1W07A 3GQTA 4NXLA 3X0YA 3D9DA 1U8VA 3EOMA 3D9EA 3MKHA 3BNFA 3TTBA 2IX5A 3F29A 4M9AA 2EBAA 1R2JA 2JBSA 3D6BA 3D9FA 4RM7A 3D9GA 2YYLA 3MMOA 4Q0TA 4ZXVA 3GNCA 4L38A 4Q17A 2E80A 2WBIA 3BNHA 2Z1QA 3SWOA 1WS9A 4KCFA 3MDDA 3II9A 3TORA 3MDEA 4Q1OA 2UXWA 3LGQA 3UBRA 3BNGA 2JBRA 3P4TA 4IRNA 3AFFA 2DVLA 3MPIA 3HWCA 3M9VA 1EGEA 2YYMA 1T9GA 2ZAFA 2R0NA 4L3XA 3SXQA 1FS9A 3S7WA 5K3JA 4L3YA 4X28C 4Q5CA 3SCEA 2A1TA 4G5EA 2IX6A 4P13A 2YYIA 1IS2A 3D1IA 2RF7A 2FONA 2YYKA 1EGCA 1SIQA 1QDBA 4W9UA 2JIFA 4O5MA 3L1TA 2VR0A 4WJYA 4IV6A 2YYGA 2ZO5A 2PG0A 4Q5BA 1EGDA 2D29A 3NF4A 2C0UA 3PFDA 1SIRA 5K3IA 1OAHA 4JEKA 5K3HA 1JQIA 2VIGA 3FO3A 1RX0A 3UU9A 2CX9A 3X0XA 3GM6A 2REHA 2R0MA 4Q4UA 4HR3A 4U83A 1UKWA 2OR0A 4X28A 2E81A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LG1 A;  1IVH A;  3AFE A;  3OWM A;  1FS7 A;  2RDZ A;  1GU6 A;  2C12 A;  2J7A A;  3MPJ A;  3OIB A;  4DOY A;  4L1F A;  1BUC A;  3B96 A;  1UDY A;  2RFQ A;  3FCJ A;  3EON A;  5K3G A;  2JBT A;  2OT4 A;  3MXL A;  4N5F A;  4XVX A;  4OO2 A;  3RKH A;  4KTO A;  3OWA A;  3R7K A;  4ZYJ A;  3SF6 A;  3BNJ A;  2DDH A;  4L3Z A;  1FS8 A;  2YYJ A;  1W07 A;  3GQT A;  4NXL A;  3X0Y A;  3D9D A;  1U8V A;  3EOM A;  3D9E A;  3MKH A;  3BNF A;  3TTB A;  2IX5 A;  3F29 A;  4M9A A;  2EBA A;  1R2J A;  2JBS A;  3D6B A;  3D9F A;  4RM7 A;  3D9G A;  2YYL A;  3MMO A;  4Q0T A;  4ZXV A;  3GNC A;  4L38 A;  4Q17 A;  2E80 A;  2WBI A;  3BNH A;  2Z1Q A;  3SWO A;  1WS9 A;  4KCF A;  3MDD A;  3II9 A;  3TOR A;  3MDE A;  4Q1O A;  2UXW A;  3LGQ A;  3UBR A;  3BNG A;  2JBR A;  3P4T A;  4IRN A;  3AFF A;  2DVL A;  3MPI A;  3HWC A;  3M9V A;  1EGE A;  2YYM A;  1T9G A;  2ZAF A;  2R0N A;  4L3X A;  3SXQ A;  1FS9 A;  3S7W A;  5K3J A;  4L3Y A;  4X28 C;  4Q5C A;  3SCE A;  2A1T A;  4G5E A;  2IX6 A;  4P13 A;  2YYI A;  1IS2 A;  3D1I A;  2RF7 A;  2FON A;  2YYK A;  1EGC A;  1SIQ A;  1QDB A;  4W9U A;  2JIF A;  4O5M A;  3L1T A;  2VR0 A;  4WJY A;  4IV6 A;  2YYG A;  2ZO5 A;  2PG0 A;  4Q5B A;  1EGD A;  2D29 A;  3NF4 A;  2C0U A;  3PFD A;  1SIR A;  5K3I A;  1OAH A;  4JEK A;  5K3H A;  1JQI A;  2VIG A;  3FO3 A;  1RX0 A;  3UU9 A;  2CX9 A;  3X0X A;  3GM6 A;  2REH A;  2R0M A;  4Q4U A;  4HR3 A;  4U83 A;  1UKW A;  2OR0 A;  4X28 A;  2E81 A; 
#chains in the Genus database with same CATH topology
 3LG1 A;  1IVH A;  3AFE A;  3TZ5 A;  2EBH X;  3CRL A;  2ZDX A;  1FS7 A;  2PO4 A;  2RDZ A;  3OWM A;  3Q0A A;  1GU6 A;  2C12 A;  2J7A A;  3MPJ A;  1GKZ A;  2R03 A;  3OIB A;  4DOY A;  4L1F A;  1Y8P A;  4AI6 A;  2BU6 A;  3U33 A;  1BUC A;  3B96 A;  1UDY A;  1XG2 B;  2LFW A;  2RFQ A;  3FCJ A;  3EON A;  5K3G A;  4LQQ B;  2CJ6 A;  4HKS A;  4JIZ A;  1Y8O A;  2YGW A;  2JBT A;  1XFY A;  4V26 A;  2OT4 A;  3MXL A;  4N5F A;  4XVX A;  3KML A;  4OO2 A;  3RKH A;  5M4M A;  4KTO A;  3OWA A;  5GJV E;  2GBB A;  1RJ4 A;  5BRM A;  3R7K A;  4ZYJ A;  2QR4 A;  2Q8F A;  4F0X A;  3SF6 A;  4DZY A;  5GJW E;  3BNJ A;  2DDH A;  4L3Z A;  3D2R A;  1S26 A;  1FS8 A;  2YYJ A;  3N0R A;  1W07 A;  4G97 A;  3GQT A;  5J6A A;  3Q22 A;  4NXL A;  1XFW A;  2R02 A;  3C3L A;  4FF3 A;  5B6B A;  3X0Y A;  3D9D A;  1U8V A;  2BU5 A;  3EOM A;  4P79 A;  5EZ3 A;  3D9E A;  4H7Q A;  3MKH A;  3BNF A;  3TTB A;  2IX5 A;  2CJ5 A;  4J1V A;  3F29 A;  4FZ4 A;  4M9A A;  2EBA A;  1R2J A;  2JBS A;  3D6B A;  3D9F A;  4RM7 A;  3D9G A;  2XQR B;  2YYL A;  4KSF A;  4V25 A;  3DJL A;  2AZE A;  3MMO A;  4Q0T A;  4MPC A;  4ZXV A;  3GNC A;  4L38 A;  4Q17 A;  2CJ8 A;  2E80 A;  2WBI A;  2BTZ A;  3BNH A;  2Z1Q A;  3SWO A;  1WS9 A;  4KCF A;  1K8T A;  2ZKJ A;  3MDD A;  3II9 A;  1RJ1 A;  2BU2 A;  3TOR A;  3MDE A;  1PI1 A;  3VAD A;  4FF1 A;  3VKH A;  4Q1O A;  2UXW A;  3LGQ A;  3UBR A;  2R05 A;  1XFX A;  2XS8 A;  3BNG A;  2JBR A;  2HJN A;  3P4T A;  4IRN A;  2CJ7 A;  2ZDY A;  3AFF A;  1X91 A;  5M4K A;  4MPN A;  2DVL A;  3MPI A;  4KS9 A;  3HWC A;  2AO2 A;  3M9V A;  1K93 A;  1EGE A;  2YYM A;  4FF2 A;  1T9G A;  2ZAF A;  5B5W A;  2R0N A;  4L3X A;  1X90 A;  3SXQ A;  1FS9 A;  5BRK A;  3X29 A;  3S7W A;  5M4N A;  4LQS B;  4QIC A;  1GKX A;  5K3J A;  1Y8N A;  4L3Y A;  2Q8I A;  5M4P A;  3C46 A;  1SK6 A;  1XFZ A;  4X28 C;  1XFU A;  2OJQ A;  3CE2 A;  4Q5C A;  2A1T A;  3SCE A;  1SC5 A;  2E0A A;  3TZ4 A;  4AKG A;  4G5E A;  4MPE A;  2IX6 A;  2EC5 A;  4P13 A;  1PK0 A;  2YYI A;  3CRK A;  1IS2 A;  3D1I A;  3VKG A;  2RF7 A;  2FON A;  4HKR A;  1JM6 A;  3Q24 A;  2BU8 A;  4E02 A;  2YYK A;  1XFV A;  1EGC A;  3Q23 A;  1SIQ A;  4MP2 A;  1QDB A;  4W9U A;  1X8Z A;  4FF4 A;  4H81 A;  1RP3 A;  2JIF A;  4O5M A;  3L1T A;  4JIO A;  4MP7 A;  2VR0 A;  3TZ0 A;  4WJY A;  4IV6 A;  2YYG A;  2ZO5 A;  4KSA A;  2PG0 A;  4Q5B A;  2BU7 A;  3TZ2 A;  4E00 A;  1EGD A;  2XS1 A;  2VF1 A;  1GJV A;  2D29 A;  3NF4 A;  2C0U A;  2FP1 A;  4E01 A;  3PFD A;  2CJ4 A;  1SIR A;  5K3I A;  1OAH A;  4AKI A;  4JEK A;  5K3H A;  1JQI A;  4AKH A;  2VIG A;  2F6L A;  1R3B A;  2PNR A;  3FO3 A;  1RX0 A;  2EBF X;  3UU9 A;  2CX9 A;  3X0X A;  1K90 A;  2FP2 A;  4H85 A;  3GM6 A;  2Q8H A;  5J71 A;  1LVC A;  2OEX A;  2REH A;  2Q8G A;  2R0M A;  5B5V A;  4Q4U A;  4HR3 A;  4U83 A;  1Y0V A;  1UKW A;  2OR0 A;  2OEV A;  3C2P A;  4X28 A;  2E81 A; 
#chains in the Genus database with same CATH homology
 3LG1 A;  1IVH A;  3AFE A;  3OWM A;  1FS7 A;  2RDZ A;  1GU6 A;  2C12 A;  2J7A A;  3MPJ A;  3OIB A;  4DOY A;  4L1F A;  1BUC A;  3B96 A;  1UDY A;  2RFQ A;  3FCJ A;  3EON A;  5K3G A;  2JBT A;  2OT4 A;  3MXL A;  4N5F A;  4XVX A;  4OO2 A;  3RKH A;  4KTO A;  3OWA A;  3R7K A;  4ZYJ A;  3SF6 A;  3BNJ A;  2DDH A;  4L3Z A;  1FS8 A;  2YYJ A;  1W07 A;  3GQT A;  4NXL A;  3X0Y A;  3D9D A;  1U8V A;  3EOM A;  3D9E A;  3MKH A;  3BNF A;  3TTB A;  2IX5 A;  3F29 A;  4M9A A;  2EBA A;  1R2J A;  2JBS A;  3D6B A;  3D9F A;  4RM7 A;  3D9G A;  2YYL A;  3MMO A;  4Q0T A;  4ZXV A;  3GNC A;  4L38 A;  4Q17 A;  2E80 A;  2WBI A;  3BNH A;  2Z1Q A;  3SWO A;  1WS9 A;  4KCF A;  3MDD A;  3II9 A;  3TOR A;  3MDE A;  4Q1O A;  2UXW A;  3LGQ A;  3UBR A;  3BNG A;  2JBR A;  3P4T A;  4IRN A;  3AFF A;  2DVL A;  3MPI A;  3HWC A;  3M9V A;  1EGE A;  2YYM A;  1T9G A;  2ZAF A;  2R0N A;  4L3X A;  3SXQ A;  1FS9 A;  3S7W A;  5K3J A;  4L3Y A;  4X28 C;  4Q5C A;  3SCE A;  2A1T A;  4G5E A;  2IX6 A;  4P13 A;  2YYI A;  1IS2 A;  3D1I A;  2RF7 A;  2FON A;  2YYK A;  1EGC A;  1SIQ A;  1QDB A;  4W9U A;  2JIF A;  4O5M A;  3L1T A;  2VR0 A;  4WJY A;  4IV6 A;  2YYG A;  2ZO5 A;  2PG0 A;  4Q5B A;  1EGD A;  2D29 A;  3NF4 A;  2C0U A;  3PFD A;  1SIR A;  5K3I A;  1OAH A;  4JEK A;  5K3H A;  1JQI A;  2VIG A;  3FO3 A;  1RX0 A;  3UU9 A;  2CX9 A;  3X0X A;  3GM6 A;  2REH A;  2R0M A;  4Q4U A;  4HR3 A;  4U83 A;  1UKW A;  2OR0 A;  4X28 A;  2E81 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...