4HKSA

Calcium release-activated calcium (crac) channel orai, k163w mutant
Total Genus 65
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
191
structure length
165
Chain Sequence
TYLSWRKLQLSRAKLKASSWTSALLSGFAMVAMVEVQMLIAFAICTTLLVAVHMLALMISTCILPNPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSRRAAWSATVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQDHLEHH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Crystal structure of the calcium release-activated calcium channel Orai.
pubmed doi rcsb
molecule tags Transport protein
source organism Drosophila melanogaster
molecule keywords Calcium release-activated calcium channel protein 1
total genus 65
structure length 165
sequence length 191
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-10-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07856 Orai-1 Mediator of CRAC channel activity
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.140 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 4hksA00
4HKSA 4HKRA
chains in the Genus database with same CATH superfamily
2UXWA 4JIZA 4AKIA 4Q5CA 1X91A 3TTBA 3P4TA 3MMOA 2C12A 5M4MA 3D9FA 1U8VA 3C3LA 2CJ8A 5GJVE 3S7WA 1FS8A 3BNGA 2EC5A 1LVCA 2QR4A 3D9EA 3MDEA 4IRNA 4JEKA 3EOMA 4MPCA 5J71A 1SIQA 2OEVA 2IX6A 3SF6A 3VKHA 4Q1OA 4Q4UA 5B5VA 4H7QA 1EGDA 2A1TA 4ZYJA 4AI6A 4KSFA 1FS9A 1GKXA 1UKWA 1FS7A 3R7KA 2AZEA 2Z1QA 2JIFA 2ZDXA 3LGQA 4KCFA 4NXLA 4Q5BA 4RM7A 5BRKA 3N0RA 4DZYA 2R0NA 4P79A 2E81A 3UU9A 2E80A 1PI1A 3LG1A 3FCJA 3AFEA 3MXLA 4AKGA 4G97A 4L38A 4LQQB 3AFFA 2ZDYA 2VR0A 1K90A 3BNHA 2F6LA 3GNCA 1RJ1A 2CJ4A 4Q0TA 3GQTA 4J1VA 1RP3A 2DVLA 4E01A 4U83A 3TZ4A 1PK0A 1RX0A 4MPEA 2OJQA 2REHA 2Q8HA 5BRMA 2E0AA 3C46A 3Q24A 3OWAA 1BUCA 4WJYA 2EBAA 2VIGA 4OO2A 2JBRA 2YYJA 1K8TA 3NF4A 1GJVA 1K93A 2BTZA 3D2RA 3FO3A 4X28C 2Q8IA 3TZ0A 5K3JA 1W07A 1X8ZA 1WS9A 2YGWA 5B6BA 2BU8A 2OR0A 2R0MA 3D9GA 2FONA 1QDBA 3F29A 4L3YA 3X0YA 4O5MA 1OAHA 3Q22A 2RFQA 4FF1A 2RF7A 2R03A 1R2JA 4KSAA 4JIOA 2FP2A 2YYGA 3B96A 1XFWA 4HR3A 2GBBA 3TZ2A 5M4NA 3EONA 2XQRB 4E02A 3D9DA 1X90A 3HWCA 3CRKA 4G5EA 1GU6A 1XG2B 2ZAFA 3C2PA 1JM6A 3X29A 2YYLA 1Y0VA 2PNRA 2CJ7A 2R02A 4KTOA 3SWOA 3SXQA 3MPJA 5K3HA 2JBSA 3X0XA 4L3XA 1SIRA 4XVXA 4H81A 4KS9A 4FF2A 4W9UA 2BU5A 4HKSA 1EGEA 1XFYA 2ZKJA 3D6BA 4Q17A 2Q8GA 4E00A 2CX9A 1Y8PA 2AO2A 4FF4A 4L1FA 4L3ZA 5M4KA 1IS2A 2DDHA 3BNFA 4MP2A 2XS1A 4P13A 4HKRA 5M4PA 2WBIA 2YYIA 2PG0A 2LFWA 3BNJA 1SC5A 3CE2A 3L1TA 3UBRA 3MKHA 4MPNA 1GKZA 4FF3A 1UDYA 2VF1A 5J6AA 3II9A 4X28A 4V26A 3RKHA 2IX5A 1XFZA 1XFUA 2CJ5A 4IV6A 3MPIA 2D29A 2YYMA 3CRLA 3MDDA 1Y8OA 2JBTA 4LQSB 3TORA 4ZXVA 3VADA 3Q0AA 2EBFX 3GM6A 4V25A 1Y8NA 1RJ4A 2XS8A 3D1IA 3VKGA 3Q23A 2C0UA 3TZ5A 5K3IA 1R3BA 4H85A 4N5FA 2Q8FA 3OWMA 1JQIA 2FP1A 5B5WA 2OT4A 3PFDA 4F0XA 1T9GA 2RDZA 2R05A 1IVHA 1S26A 4FZ4A 2PO4A 3KMLA 4AKHA 2CJ6A 2BU6A 1XFXA 2EBHX 2BU7A 2HJNA 2YYKA 1XFVA 3OIBA 4M9AA 3SCEA 1SK6A 4QICA 5K3GA 2ZO5A 5GJWE 4DOYA 2OEXA 2BU2A 3M9VA 4MP7A 2J7AA 1EGCA
chains in the Genus database with same CATH topology
4AKIA 4G97A 4FF3A 4AKGA 1K90A 2VF1A 2F6LA 3C2PA 3C3LA 3X29A 1XFZA 1XFUA 1Y0VA 1RP3A 5GJVE 1PK0A 2EC5A 1LVCA 2QR4A 3Q0AA 3C46A 4FF2A 2EBFX 3VKGA 3Q24A 3Q23A 3VKHA 4KS9A 1K8TA 4HKSA 1K93A 2FP1A 1XFYA 4AI6A 4KSFA 4F0XA 2AZEA 2AO2A 4FZ4A 1S26A 2YGWA 4FF4A 2PO4A 3KMLA 4AKHA 1XFXA 2EBHX 3N0RA 3Q22A 4FF1A 1XFVA 1SK6A 4HKRA 4P79A 4KSAA 4QICA 5GJWE 2FP2A 2LFWA 3CE2A 1SC5A 1XFWA 2GBBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HKS A;  4HKR A; 
#chains in the Genus database with same CATH topology
 2UXW A;  4JIZ A;  4AKI A;  4Q5C A;  1X91 A;  3TTB A;  3P4T A;  3MMO A;  2C12 A;  5M4M A;  3D9F A;  1U8V A;  3C3L A;  2CJ8 A;  5GJV E;  3S7W A;  1FS8 A;  3BNG A;  2EC5 A;  1LVC A;  2QR4 A;  3D9E A;  3MDE A;  4IRN A;  4JEK A;  3EOM A;  4MPC A;  5J71 A;  1SIQ A;  2OEV A;  2IX6 A;  3SF6 A;  3VKH A;  4Q1O A;  4Q4U A;  5B5V A;  4H7Q A;  1EGD A;  2A1T A;  4ZYJ A;  4AI6 A;  4KSF A;  1FS9 A;  1GKX A;  1UKW A;  1FS7 A;  3R7K A;  2AZE A;  2Z1Q A;  2JIF A;  2ZDX A;  3LGQ A;  4KCF A;  4NXL A;  4Q5B A;  4RM7 A;  5BRK A;  3N0R A;  4DZY A;  2R0N A;  4P79 A;  2E81 A;  3UU9 A;  2E80 A;  1PI1 A;  3LG1 A;  3FCJ A;  3AFE A;  3MXL A;  4AKG A;  4G97 A;  4L38 A;  4LQQ B;  3AFF A;  2ZDY A;  2VR0 A;  1K90 A;  3BNH A;  2F6L A;  3GNC A;  1RJ1 A;  2CJ4 A;  4Q0T A;  3GQT A;  4J1V A;  1RP3 A;  2DVL A;  4E01 A;  4U83 A;  3TZ4 A;  1PK0 A;  1RX0 A;  4MPE A;  2OJQ A;  2REH A;  2Q8H A;  5BRM A;  2E0A A;  3C46 A;  3Q24 A;  3OWA A;  1BUC A;  4WJY A;  2EBA A;  2VIG A;  4OO2 A;  2JBR A;  2YYJ A;  1K8T A;  3NF4 A;  1GJV A;  1K93 A;  2BTZ A;  3D2R A;  3FO3 A;  4X28 C;  2Q8I A;  3TZ0 A;  5K3J A;  1W07 A;  1X8Z A;  1WS9 A;  2YGW A;  5B6B A;  2BU8 A;  2OR0 A;  2R0M A;  3D9G A;  2FON A;  1QDB A;  3F29 A;  4L3Y A;  3X0Y A;  4O5M A;  1OAH A;  3Q22 A;  2RFQ A;  4FF1 A;  2RF7 A;  2R03 A;  1R2J A;  4KSA A;  4JIO A;  2FP2 A;  2YYG A;  3B96 A;  1XFW A;  4HR3 A;  2GBB A;  3TZ2 A;  5M4N A;  3EON A;  2XQR B;  4E02 A;  3D9D A;  1X90 A;  3HWC A;  3CRK A;  4G5E A;  1GU6 A;  1XG2 B;  2ZAF A;  3C2P A;  1JM6 A;  3X29 A;  2YYL A;  1Y0V A;  2PNR A;  2CJ7 A;  2R02 A;  4KTO A;  3SWO A;  3SXQ A;  3MPJ A;  5K3H A;  2JBS A;  3X0X A;  4L3X A;  1SIR A;  4XVX A;  4H81 A;  4KS9 A;  4FF2 A;  4W9U A;  2BU5 A;  4HKS A;  1EGE A;  1XFY A;  2ZKJ A;  3D6B A;  4Q17 A;  2Q8G A;  4E00 A;  2CX9 A;  1Y8P A;  2AO2 A;  4FF4 A;  4L1F A;  4L3Z A;  5M4K A;  1IS2 A;  2DDH A;  3BNF A;  4MP2 A;  2XS1 A;  4P13 A;  4HKR A;  5M4P A;  2WBI A;  2YYI A;  2PG0 A;  2LFW A;  3BNJ A;  1SC5 A;  3CE2 A;  3L1T A;  3UBR A;  3MKH A;  4MPN A;  1GKZ A;  4FF3 A;  1UDY A;  2VF1 A;  5J6A A;  3II9 A;  4X28 A;  4V26 A;  3RKH A;  2IX5 A;  1XFZ A;  1XFU A;  2CJ5 A;  4IV6 A;  3MPI A;  2D29 A;  2YYM A;  3CRL A;  3MDD A;  1Y8O A;  2JBT A;  4LQS B;  3TOR A;  4ZXV A;  3VAD A;  3Q0A A;  2EBF X;  3GM6 A;  4V25 A;  1Y8N A;  1RJ4 A;  2XS8 A;  3D1I A;  3VKG A;  3Q23 A;  2C0U A;  3TZ5 A;  5K3I A;  1R3B A;  4H85 A;  4N5F A;  2Q8F A;  3OWM A;  1JQI A;  2FP1 A;  5B5W A;  2OT4 A;  3PFD A;  4F0X A;  1T9G A;  2RDZ A;  2R05 A;  1IVH A;  1S26 A;  4FZ4 A;  2PO4 A;  3KML A;  4AKH A;  2CJ6 A;  2BU6 A;  1XFX A;  2EBH X;  2BU7 A;  2HJN A;  2YYK A;  1XFV A;  3OIB A;  4M9A A;  3SCE A;  1SK6 A;  4QIC A;  5K3G A;  2ZO5 A;  5GJW E;  4DOY A;  2OEX A;  2BU2 A;  3M9V A;  4MP7 A;  2J7A A;  1EGC A; 
#chains in the Genus database with same CATH homology
 4AKI A;  4G97 A;  4FF3 A;  4AKG A;  1K90 A;  2VF1 A;  2F6L A;  3C2P A;  3C3L A;  3X29 A;  1XFZ A;  1XFU A;  1Y0V A;  1RP3 A;  5GJV E;  1PK0 A;  2EC5 A;  1LVC A;  2QR4 A;  3Q0A A;  3C46 A;  4FF2 A;  2EBF X;  3VKG A;  3Q24 A;  3Q23 A;  3VKH A;  4KS9 A;  1K8T A;  4HKS A;  1K93 A;  2FP1 A;  1XFY A;  4AI6 A;  4KSF A;  4F0X A;  2AZE A;  2AO2 A;  4FZ4 A;  1S26 A;  2YGW A;  4FF4 A;  2PO4 A;  3KML A;  4AKH A;  1XFX A;  2EBH X;  3N0R A;  3Q22 A;  4FF1 A;  1XFV A;  1SK6 A;  4HKR A;  4P79 A;  4KSA A;  4QIC A;  5GJW E;  2FP2 A;  2LFW A;  3CE2 A;  1SC5 A;  1XFW A;  2GBB A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...