4HKSA

Calcium release-activated calcium (crac) channel orai, k163w mutant
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
191
structure length
165
Chain Sequence
TYLSWRKLQLSRAKLKASSWTSALLSGFAMVAMVEVQMLIAFAICTTLLVAVHMLALMISTCILPNPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSRRAAWSATVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQDHLEHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the calcium release-activated calcium channel Orai.
pubmed doi rcsb
molecule tags Transport protein
source organism Drosophila melanogaster
molecule keywords Calcium release-activated calcium channel protein 1
total genus 65
structure length 165
sequence length 191
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-10-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07856 Orai-1 Mediator of CRAC channel activity
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.140 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 4hksA00
4HKRA 4HKSA
chains in the Genus database with same CATH superfamily
3D2RA 2ZDXA 2RDZA 1RP3A 2XS8A 2BU6A 3AFFA 3NF4A 4DZYA 2QR4A 2ZKJA 3Q24A 4Q17A 3MDDA 3Q22A 1PI1A 2XS1A 3N0RA 3TORA 2RF7A 4J1VA 4QICA 1BUCA 3OWMA 2EBHX 1Y8OA 1RJ4A 3KMLA 3PFDA 3X0XA 4W9UA 1GJVA 5B5VA 3TZ2A 2R02A 3GM6A 3Q0AA 1WS9A 1RJ1A 2ZDYA 1GKZA 3LG1A 4P13A 5B5WA 1W07A 4WJYA 4AKGA 2PG0A 4MPNA 5BRMA 2PO4A 1RX0A 1X8ZA 4HKSA 4L1FA 2R0NA 2FP2A 2Z1QA 1IS2A 3CRLA 2Q8FA 2CX9A 3X0YA 1Y8NA 3EOMA 1LVCA 4L3ZA 2EBFX 4M9AA 3B96A 3CE2A 2R0MA 2C0UA 2Q8IA 3BNHA 2AZEA 4H81A 4KSFA 4U83A 4FF3A 3TZ5A 1XG2B 1FS8A 3SWOA 4O5MA 1K90A 1XFVA 1XFWA 2EBAA 3D9FA 3F29A 4FF2A 2EC5A 2YYMA 2ZAFA 1R3BA 4JIOA 5J71A 4ZXVA 1K93A 2OR0A 4LQSB 4AKIA 4Q5BA 3LGQA 3AFEA 2HJNA 5K3GA 3D1IA 2OJQA 5GJVE 1EGDA 2DDHA 1T9GA 3UBRA 4E02A 4HKRA 2CJ5A 4AI6A 4XVXA 5J6AA 3RKHA 2IX5A 4P79A 1OAHA 2A1TA 2BTZA 2E0AA 3BNFA 3MPIA 5BRKA 3HWCA 2XQRB 2RFQA 4G5EA 2REHA 1SC5A 3GNCA 2Q8GA 3FO3A 2FONA 1K8TA 4LQQB 3C2PA 2VF1A 1JM6A 1XFUA 3FCJA 3BNGA 3D9DA 1UDYA 1Y0VA 2PNRA 1SIQA 1SK6A 1QDBA 2YGWA 2YYJA 3D9EA 3OWAA 4G97A 4X28A 4L3XA 2E81A 4KCFA 4FZ4A 1GKXA 1IVHA 2JBTA 3MXLA 2OT4A 2C12A 1FS9A 3MDEA 3EONA 4MP7A 4E00A 4ZYJA 5M4KA 5M4PA 4FF1A 2YYLA 1GU6A 3P4TA 4FF4A 3SCEA 4E01A 4IV6A 1U8VA 1FS7A 3VKHA 2VIGA 2E80A 1XFXA 1Y8PA 3C46A 3M9VA 2VR0A 1X91A 4IRNA 3MMOA 5K3HA 4F0XA 3C3LA 4Q0TA 4V25A 1SIRA 4HR3A 3BNJA 3D9GA 2YYIA 1EGCA 2YYKA 4V26A 2OEXA 5K3IA 1PK0A 4DOYA 2CJ4A 2BU8A 4NXLA 3CRKA 2CJ8A 3TTBA 3VKGA 2JBRA 3D6BA 3II9A 3L1TA 4RM7A 2AO2A 1XFYA 4L3YA 1JQIA 2CJ6A 3VADA 2WBIA 2BU7A 4H7QA 3SF6A 4Q1OA 3X29A 2BU5A 2D29A 4MPCA 2UXWA 4KTOA 5GJWE 3TZ0A 1R2JA 5K3JA 3SXQA 1EGEA 4H85A 4KS9A 5M4NA 1S26A 3MKHA 2JBSA 2JIFA 3MPJA 2R05A 2FP1A 4JEKA 3UU9A 2CJ7A 2F6LA 2R03A 3R7KA 1X90A 4KSAA 3Q23A 4MP2A 1UKWA 3S7WA 4MPEA 2LFWA 5B6BA 4L38A 4Q4UA 3TZ4A 2IX6A 4Q5CA 2J7AA 4JIZA 2BU2A 2Q8HA 2DVLA 2YYGA 1XFZA 2ZO5A 4AKHA 3GQTA 4N5FA 4X28C 5M4MA 2GBBA 4OO2A 2OEVA 3OIBA
chains in the Genus database with same CATH topology
4FZ4A 1K90A 1XFVA 1XFWA 1RP3A 4FF2A 2EC5A 1XFYA 2QR4A 1K93A 3X29A 3Q24A 2YGWA 4FF1A 4AKIA 3Q22A 5GJWE 3N0RA 4FF4A 4QICA 3VKHA 4KS9A 1S26A 5GJVE 1XFXA 2EBHX 3KMLA 3C46A 2FP1A 2F6LA 4HKRA 4KSAA 3Q0AA 3Q23A 3C3LA 4AI6A 4P79A 2LFWA 4AKGA 1PK0A 2PO4A 4HKSA 1SC5A 2FP2A 1K8TA 4AKHA 3C2PA 1XFZA 2VF1A 1LVCA 1XFUA 2EBFX 3VKGA 3CE2A 1Y0VA 2GBBA 4F0XA 1SK6A 4G97A 2AZEA 4KSFA 2AO2A 4FF3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HKR A;  4HKS A; 
#chains in the Genus database with same CATH topology
 3D2R A;  2ZDX A;  2RDZ A;  1RP3 A;  2XS8 A;  2BU6 A;  3AFF A;  3NF4 A;  4DZY A;  2QR4 A;  2ZKJ A;  3Q24 A;  4Q17 A;  3MDD A;  3Q22 A;  1PI1 A;  2XS1 A;  3N0R A;  3TOR A;  2RF7 A;  4J1V A;  4QIC A;  1BUC A;  3OWM A;  2EBH X;  1Y8O A;  1RJ4 A;  3KML A;  3PFD A;  3X0X A;  4W9U A;  1GJV A;  5B5V A;  3TZ2 A;  2R02 A;  3GM6 A;  3Q0A A;  1WS9 A;  1RJ1 A;  2ZDY A;  1GKZ A;  3LG1 A;  4P13 A;  5B5W A;  1W07 A;  4WJY A;  4AKG A;  2PG0 A;  4MPN A;  5BRM A;  2PO4 A;  1RX0 A;  1X8Z A;  4HKS A;  4L1F A;  2R0N A;  2FP2 A;  2Z1Q A;  1IS2 A;  3CRL A;  2Q8F A;  2CX9 A;  3X0Y A;  1Y8N A;  3EOM A;  1LVC A;  4L3Z A;  2EBF X;  4M9A A;  3B96 A;  3CE2 A;  2R0M A;  2C0U A;  2Q8I A;  3BNH A;  2AZE A;  4H81 A;  4KSF A;  4U83 A;  4FF3 A;  3TZ5 A;  1XG2 B;  1FS8 A;  3SWO A;  4O5M A;  1K90 A;  1XFV A;  1XFW A;  2EBA A;  3D9F A;  3F29 A;  4FF2 A;  2EC5 A;  2YYM A;  2ZAF A;  1R3B A;  4JIO A;  5J71 A;  4ZXV A;  1K93 A;  2OR0 A;  4LQS B;  4AKI A;  4Q5B A;  3LGQ A;  3AFE A;  2HJN A;  5K3G A;  3D1I A;  2OJQ A;  5GJV E;  1EGD A;  2DDH A;  1T9G A;  3UBR A;  4E02 A;  4HKR A;  2CJ5 A;  4AI6 A;  4XVX A;  5J6A A;  3RKH A;  2IX5 A;  4P79 A;  1OAH A;  2A1T A;  2BTZ A;  2E0A A;  3BNF A;  3MPI A;  5BRK A;  3HWC A;  2XQR B;  2RFQ A;  4G5E A;  2REH A;  1SC5 A;  3GNC A;  2Q8G A;  3FO3 A;  2FON A;  1K8T A;  4LQQ B;  3C2P A;  2VF1 A;  1JM6 A;  1XFU A;  3FCJ A;  3BNG A;  3D9D A;  1UDY A;  1Y0V A;  2PNR A;  1SIQ A;  1SK6 A;  1QDB A;  2YGW A;  2YYJ A;  3D9E A;  3OWA A;  4G97 A;  4X28 A;  4L3X A;  2E81 A;  4KCF A;  4FZ4 A;  1GKX A;  1IVH A;  2JBT A;  3MXL A;  2OT4 A;  2C12 A;  1FS9 A;  3MDE A;  3EON A;  4MP7 A;  4E00 A;  4ZYJ A;  5M4K A;  5M4P A;  4FF1 A;  2YYL A;  1GU6 A;  3P4T A;  4FF4 A;  3SCE A;  4E01 A;  4IV6 A;  1U8V A;  1FS7 A;  3VKH A;  2VIG A;  2E80 A;  1XFX A;  1Y8P A;  3C46 A;  3M9V A;  2VR0 A;  1X91 A;  4IRN A;  3MMO A;  5K3H A;  4F0X A;  3C3L A;  4Q0T A;  4V25 A;  1SIR A;  4HR3 A;  3BNJ A;  3D9G A;  2YYI A;  1EGC A;  2YYK A;  4V26 A;  2OEX A;  5K3I A;  1PK0 A;  4DOY A;  2CJ4 A;  2BU8 A;  4NXL A;  3CRK A;  2CJ8 A;  3TTB A;  3VKG A;  2JBR A;  3D6B A;  3II9 A;  3L1T A;  4RM7 A;  2AO2 A;  1XFY A;  4L3Y A;  1JQI A;  2CJ6 A;  3VAD A;  2WBI A;  2BU7 A;  4H7Q A;  3SF6 A;  4Q1O A;  3X29 A;  2BU5 A;  2D29 A;  4MPC A;  2UXW A;  4KTO A;  5GJW E;  3TZ0 A;  1R2J A;  5K3J A;  3SXQ A;  1EGE A;  4H85 A;  4KS9 A;  5M4N A;  1S26 A;  3MKH A;  2JBS A;  2JIF A;  3MPJ A;  2R05 A;  2FP1 A;  4JEK A;  3UU9 A;  2CJ7 A;  2F6L A;  2R03 A;  3R7K A;  1X90 A;  4KSA A;  3Q23 A;  4MP2 A;  1UKW A;  3S7W A;  4MPE A;  2LFW A;  5B6B A;  4L38 A;  4Q4U A;  3TZ4 A;  2IX6 A;  4Q5C A;  2J7A A;  4JIZ A;  2BU2 A;  2Q8H A;  2DVL A;  2YYG A;  1XFZ A;  2ZO5 A;  4AKH A;  3GQT A;  4N5F A;  4X28 C;  5M4M A;  2GBB A;  4OO2 A;  2OEV A;  3OIB A; 
#chains in the Genus database with same CATH homology
 4FZ4 A;  1K90 A;  1XFV A;  1XFW A;  1RP3 A;  4FF2 A;  2EC5 A;  1XFY A;  2QR4 A;  1K93 A;  3X29 A;  3Q24 A;  2YGW A;  4FF1 A;  4AKI A;  3Q22 A;  5GJW E;  3N0R A;  4FF4 A;  4QIC A;  3VKH A;  4KS9 A;  1S26 A;  5GJV E;  1XFX A;  2EBH X;  3KML A;  3C46 A;  2FP1 A;  2F6L A;  4HKR A;  4KSA A;  3Q0A A;  3Q23 A;  3C3L A;  4AI6 A;  4P79 A;  2LFW A;  4AKG A;  1PK0 A;  2PO4 A;  4HKS A;  1SC5 A;  2FP2 A;  1K8T A;  4AKH A;  3C2P A;  1XFZ A;  2VF1 A;  1LVC A;  1XFU A;  2EBF X;  3VKG A;  3CE2 A;  1Y0V A;  2GBB A;  4F0X A;  1SK6 A;  4G97 A;  2AZE A;  4KSF A;  2AO2 A;  4FF3 A; 
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