5BRMA

Structural basis for mob1-dependent activation of the core mst-lats kinase cascade in hippo signaling
Total Genus 52
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
160
structure length
154
Chain Sequence
DLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Transferase/signaling protein
source organism Homo sapiens
publication title Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
pubmed doi rcsb
molecule keywords MOB kinase activator 1A
total genus 52
structure length 154
sequence length 160
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2015-05-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.30 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 MOB kinase activator 5brmA00
5B6BA 5B5VA 4LQQB 1R3BA 1PI1A 4J1VA 5B5WA 4LQSB 5BRMA 2HJNA 4JIZA 5BRKA
chains in the Genus database with same CATH superfamily
3X0YA 4Q1OA 1X90A 4FF2A 1S26A 2OJQA 2XS1A 3LGQA 1PI1A 2YYLA 4P79A 3TTBA 4IRNA 4MPNA 2OT4A 3TORA 4JEKA 3NF4A 4WJYA 2A1TA 5B5VA 3R7KA 2OEVA 2UXWA 3B96A 5M4KA 3PFDA 1UDYA 1JM6A 4JIOA 4U83A 4M9AA 4V26A 1JQIA 2DDHA 4LQSB 1EGCA 4RM7A 2OR0A 4G97A 1SK6A 2J7AA 4L38A 4AKIA 2PNRA 2BU8A 3P4TA 5J71A 5J6AA 4MP7A 3FO3A 5BRMA 2C0UA 1Y8NA 3GQTA 4G5EA 1EGDA 2WBIA 4L3XA 2R02A 4ZXVA 2Q8HA 1OAHA 2E80A 5K3IA 2CJ8A 3Q22A 4HR3A 3VADA 4X28A 4J1VA 2AZEA 1XG2B 2FP2A 2LFWA 2VIGA 2Z1QA 3TZ5A 4W9UA 4L3YA 4AKGA 3SXQA 2BTZA 5K3GA 3SWOA 5GJWE 2EBHX 2YYJA 1UKWA 1RX0A 2F6LA 3MDDA 2FP1A 4KSAA 4MPEA 3UBRA 4DOYA 4OO2A 3F29A 4KCFA 3D1IA 2IX6A 2OEXA 3C2PA 1K93A 2VF1A 4HKSA 3D9FA 2Q8GA 4V25A 4E02A 1RJ1A 2EBFX 3D9DA 2R05A 3FCJA 3X29A 4Q5BA 3SF6A 4XVXA 1XFYA 3AFFA 1QDBA 1R3BA 2XQRB 4MP2A 4QICA 2GBBA 4DZYA 1BUCA 1XFUA 2ZDYA 4ZYJA 1FS8A 1T9GA 1SIQA 1W07A 3D2RA 3CE2A 3RKHA 3D9GA 2BU2A 3II9A 2YGWA 2C12A 1Y8OA 2BU7A 2JBTA 3AFEA 2ZKJA 4KTOA 3OWAA 4Q0TA 4Q17A 3BNHA 4L1FA 3TZ0A 3TZ4A 3BNGA 2BU6A 4FZ4A 2ZAFA 4P13A 5B5WA 5M4NA 4H7QA 3CRKA 4FF4A 2CJ4A 1K90A 2E0AA 2YYGA 3SCEA 2YYIA 2DVLA 3L1TA 4NXLA 2R0MA 3HWCA 2CJ5A 3OIBA 2JBRA 2CJ7A 3S7WA 2VR0A 2XS8A 1RP3A 4LQQB 4MPCA 3UU9A 4KS9A 3D9EA 3Q0AA 5M4MA 2YYMA 4N5FA 1FS7A 1X8ZA 1XFVA 4X28C 2BU5A 3N0RA 5GJVE 1SIRA 5BRKA 5B6BA 1EGEA 2PO4A 3EONA 2PG0A 4FF1A 3Q24A 1PK0A 4KSFA 1GJVA 3MKHA 4H81A 5K3JA 3MPJA 5K3HA 1RJ4A 4JIZA 2R03A 4E00A 1XFZA 1WS9A 2Q8IA 3D6BA 1Y0VA 2R0NA 3EOMA 3KMLA 3MXLA 1LVCA 1Y8PA 3Q23A 2IX5A 3C46A 2E81A 4L3ZA 3MMOA 3CRLA 4Q5CA 4HKRA 4IV6A 2ZO5A 1XFWA 3LG1A 2CJ6A 4Q4UA 3GM6A 4FF3A 2AO2A 1GKZA 1IVHA 4H85A 4AI6A 2FONA 2RF7A 2ZDXA 1FS9A 3BNJA 2HJNA 2JIFA 1R2JA 1GU6A 2RDZA 1SC5A 4AKHA 1X91A 4E01A 1U8VA 3TZ2A 2QR4A 3BNFA 2JBSA 3C3LA 4O5MA 3MDEA 3X0XA 4F0XA 5M4PA 1K8TA 2Q8FA 2RFQA 2REHA 2YYKA 3GNCA 3M9VA 2EC5A 1XFXA 3OWMA 2D29A 1IS2A 3VKGA 3VKHA 2EBAA 3MPIA 1GKXA 2CX9A
chains in the Genus database with same CATH topology
5B6BA 5B5VA 4LQQB 1R3BA 1PI1A 4J1VA 5B5WA 4LQSB 5BRMA 2HJNA 4JIZA 5BRKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5B6B A;  5B5V A;  4LQQ B;  1R3B A;  1PI1 A;  4J1V A;  5B5W A;  4LQS B;  5BRM A;  2HJN A;  4JIZ A;  5BRK A; 
#chains in the Genus database with same CATH topology
 3X0Y A;  4Q1O A;  1X90 A;  4FF2 A;  1S26 A;  2OJQ A;  2XS1 A;  3LGQ A;  1PI1 A;  2YYL A;  4P79 A;  3TTB A;  4IRN A;  4MPN A;  2OT4 A;  3TOR A;  4JEK A;  3NF4 A;  4WJY A;  2A1T A;  5B5V A;  3R7K A;  2OEV A;  2UXW A;  3B96 A;  5M4K A;  3PFD A;  1UDY A;  1JM6 A;  4JIO A;  4U83 A;  4M9A A;  4V26 A;  1JQI A;  2DDH A;  4LQS B;  1EGC A;  4RM7 A;  2OR0 A;  4G97 A;  1SK6 A;  2J7A A;  4L38 A;  4AKI A;  2PNR A;  2BU8 A;  3P4T A;  5J71 A;  5J6A A;  4MP7 A;  3FO3 A;  5BRM A;  2C0U A;  1Y8N A;  3GQT A;  4G5E A;  1EGD A;  2WBI A;  4L3X A;  2R02 A;  4ZXV A;  2Q8H A;  1OAH A;  2E80 A;  5K3I A;  2CJ8 A;  3Q22 A;  4HR3 A;  3VAD A;  4X28 A;  4J1V A;  2AZE A;  1XG2 B;  2FP2 A;  2LFW A;  2VIG A;  2Z1Q A;  3TZ5 A;  4W9U A;  4L3Y A;  4AKG A;  3SXQ A;  2BTZ A;  5K3G A;  3SWO A;  5GJW E;  2EBH X;  2YYJ A;  1UKW A;  1RX0 A;  2F6L A;  3MDD A;  2FP1 A;  4KSA A;  4MPE A;  3UBR A;  4DOY A;  4OO2 A;  3F29 A;  4KCF A;  3D1I A;  2IX6 A;  2OEX A;  3C2P A;  1K93 A;  2VF1 A;  4HKS A;  3D9F A;  2Q8G A;  4V25 A;  4E02 A;  1RJ1 A;  2EBF X;  3D9D A;  2R05 A;  3FCJ A;  3X29 A;  4Q5B A;  3SF6 A;  4XVX A;  1XFY A;  3AFF A;  1QDB A;  1R3B A;  2XQR B;  4MP2 A;  4QIC A;  2GBB A;  4DZY A;  1BUC A;  1XFU A;  2ZDY A;  4ZYJ A;  1FS8 A;  1T9G A;  1SIQ A;  1W07 A;  3D2R A;  3CE2 A;  3RKH A;  3D9G A;  2BU2 A;  3II9 A;  2YGW A;  2C12 A;  1Y8O A;  2BU7 A;  2JBT A;  3AFE A;  2ZKJ A;  4KTO A;  3OWA A;  4Q0T A;  4Q17 A;  3BNH A;  4L1F A;  3TZ0 A;  3TZ4 A;  3BNG A;  2BU6 A;  4FZ4 A;  2ZAF A;  4P13 A;  5B5W A;  5M4N A;  4H7Q A;  3CRK A;  4FF4 A;  2CJ4 A;  1K90 A;  2E0A A;  2YYG A;  3SCE A;  2YYI A;  2DVL A;  3L1T A;  4NXL A;  2R0M A;  3HWC A;  2CJ5 A;  3OIB A;  2JBR A;  2CJ7 A;  3S7W A;  2VR0 A;  2XS8 A;  1RP3 A;  4LQQ B;  4MPC A;  3UU9 A;  4KS9 A;  3D9E A;  3Q0A A;  5M4M A;  2YYM A;  4N5F A;  1FS7 A;  1X8Z A;  1XFV A;  4X28 C;  2BU5 A;  3N0R A;  5GJV E;  1SIR A;  5BRK A;  5B6B A;  1EGE A;  2PO4 A;  3EON A;  2PG0 A;  4FF1 A;  3Q24 A;  1PK0 A;  4KSF A;  1GJV A;  3MKH A;  4H81 A;  5K3J A;  3MPJ A;  5K3H A;  1RJ4 A;  4JIZ A;  2R03 A;  4E00 A;  1XFZ A;  1WS9 A;  2Q8I A;  3D6B A;  1Y0V A;  2R0N A;  3EOM A;  3KML A;  3MXL A;  1LVC A;  1Y8P A;  3Q23 A;  2IX5 A;  3C46 A;  2E81 A;  4L3Z A;  3MMO A;  3CRL A;  4Q5C A;  4HKR A;  4IV6 A;  2ZO5 A;  1XFW A;  3LG1 A;  2CJ6 A;  4Q4U A;  3GM6 A;  4FF3 A;  2AO2 A;  1GKZ A;  1IVH A;  4H85 A;  4AI6 A;  2FON A;  2RF7 A;  2ZDX A;  1FS9 A;  3BNJ A;  2HJN A;  2JIF A;  1R2J A;  1GU6 A;  2RDZ A;  1SC5 A;  4AKH A;  1X91 A;  4E01 A;  1U8V A;  3TZ2 A;  2QR4 A;  3BNF A;  2JBS A;  3C3L A;  4O5M A;  3MDE A;  3X0X A;  4F0X A;  5M4P A;  1K8T A;  2Q8F A;  2RFQ A;  2REH A;  2YYK A;  3GNC A;  3M9V A;  2EC5 A;  1XFX A;  3OWM A;  2D29 A;  1IS2 A;  3VKG A;  3VKH A;  2EBA A;  3MPI A;  1GKX A;  2CX9 A; 
#chains in the Genus database with same CATH homology
 5B6B A;  5B5V A;  4LQQ B;  1R3B A;  1PI1 A;  4J1V A;  5B5W A;  4LQS B;  5BRM A;  2HJN A;  4JIZ A;  5BRK A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...