5BRMA

Structural basis for mob1-dependent activation of the core mst-lats kinase cascade in hippo signaling
Total Genus 52
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
160
structure length
154
Chain Sequence
DLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Transferase/signaling protein
source organism Homo sapiens
publication title Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
pubmed doi rcsb
molecule keywords MOB kinase activator 1A
total genus 52
structure length 154
sequence length 160
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2015-05-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.30 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 MOB kinase activator 5brmA00
5BRKA 5BRMA 4JIZA 1PI1A 4LQQB 2HJNA 5B5VA 4LQSB 5B5WA 1R3BA 4J1VA 5B6BA
chains in the Genus database with same CATH superfamily
3TZ4A 1SIQA 1W07A 1XFWA 2YYIA 1EGEA 4JIZA 3Q22A 2ZKJA 4MPEA 3TTBA 2EC5A 1RJ4A 4N5FA 3SCEA 2EBHX 1K93A 5M4PA 1XFVA 2JBSA 3D1IA 3D9DA 5K3IA 2LFWA 2BTZA 3BNGA 3VKGA 4XVXA 4LQQB 1FS9A 1R3BA 3GNCA 4Q4UA 5K3GA 3Q24A 1X91A 2R0NA 4Q0TA 3CRLA 2VIGA 4E01A 1RX0A 3X0XA 4KSFA 4L1FA 2RDZA 3EONA 3TZ5A 3C3LA 4FF4A 4JEKA 2FP1A 4V26A 4AKHA 2UXWA 4KTOA 3TORA 4V25A 4E00A 3AFFA 1SC5A 1Y0VA 1RP3A 2YYLA 3N0RA 1Y8PA 2Q8IA 3CE2A 4MP7A 4H81A 5GJWE 5B5VA 1T9GA 5BRMA 1SIRA 3VADA 3M9VA 2PG0A 4H85A 2JIFA 2D29A 2BU2A 2WBIA 3MXLA 2R0MA 3BNHA 5K3JA 2JBRA 2CJ6A 1FS8A 2IX6A 5J6AA 2E80A 3OWAA 2VF1A 5J71A 4JIOA 4IV6A 2EBFX 4Q5CA 3TZ0A 2ZAFA 3SXQA 4U83A 4M9AA 3VKHA 2PNRA 2YGWA 3EOMA 3MPIA 3SWOA 2E0AA 2XS1A 5M4MA 3PFDA 3P4TA 2BU5A 2YYGA 4HKSA 3BNJA 3RKHA 2AZEA 4L3XA 4G97A 3BNFA 2HJNA 5M4KA 1LVCA 2QR4A 4DOYA 3C46A 1UDYA 2XS8A 2PO4A 2CJ5A 2FP2A 4KS9A 4X28C 3X29A 1GKXA 1BUCA 3D2RA 1OAHA 1PK0A 3D9GA 2ZDYA 4KSAA 3C2PA 1PI1A 2BU7A 4P79A 2RFQA 1EGDA 2C0UA 3D9FA 4LQSB 2IX5A 5B5WA 3NF4A 4FF1A 2DDHA 3L1TA 3HWCA 1JQIA 2YYKA 3MPJA 1XG2B 4KCFA 3S7WA 3MDEA 2Q8FA 3TZ2A 3UU9A 2CJ4A 3GM6A 2GBBA 4H7QA 1RJ1A 3MKHA 2Z1QA 1R2JA 3D9EA 4OO2A 4Q17A 3X0YA 1GU6A 4L3YA 3Q0AA 4HKRA 2OR0A 4MPNA 1XFXA 2CX9A 4RM7A 4ZXVA 5M4NA 2RF7A 2R05A 5GJVE 4AKIA 2ZDXA 3KMLA 1IVHA 2OT4A 3B96A 2YYMA 1EGCA 2OEXA 1U8VA 1K90A 4MP2A 4X28A 2OJQA 3UBRA 2OEVA 1QDBA 1UKWA 1X90A 3LG1A 2EBAA 4HR3A 4L38A 4WJYA 4W9UA 2AO2A 5K3HA 4DZYA 2A1TA 3MMOA 3LGQA 4Q1OA 2J7AA 4J1VA 4MPCA 2FONA 4E02A 4ZYJA 1GKZA 1XFZA 2JBTA 5B6BA 5BRKA 1JM6A 2ZO5A 2REHA 4AI6A 2R03A 4QICA 4FF2A 4L3ZA 3F29A 4IRNA 3Q23A 3OIBA 4P13A 1Y8OA 3II9A 3D6BA 2E81A 3FCJA 2Q8GA 1S26A 2C12A 4Q5BA 2CJ8A 3FO3A 2DVLA 3AFEA 3GQTA 2VR0A 1WS9A 1FS7A 2BU8A 2BU6A 3R7KA 4FF3A 2R02A 1X8ZA 4F0XA 2CJ7A 3CRKA 1XFYA 1XFUA 4G5EA 3SF6A 4AKGA 4O5MA 2F6LA 4FZ4A 3MDDA 1Y8NA 1GJVA 1IS2A 3OWMA 2YYJA 1K8TA 2Q8HA 4NXLA 1SK6A 2XQRB
chains in the Genus database with same CATH topology
5BRKA 5BRMA 4JIZA 1PI1A 4LQQB 2HJNA 5B5VA 4LQSB 5B5WA 1R3BA 4J1VA 5B6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5BRK A;  5BRM A;  4JIZ A;  1PI1 A;  4LQQ B;  2HJN A;  5B5V A;  4LQS B;  5B5W A;  1R3B A;  4J1V A;  5B6B A; 
#chains in the Genus database with same CATH topology
 3TZ4 A;  1SIQ A;  1W07 A;  1XFW A;  2YYI A;  1EGE A;  4JIZ A;  3Q22 A;  2ZKJ A;  4MPE A;  3TTB A;  2EC5 A;  1RJ4 A;  4N5F A;  3SCE A;  2EBH X;  1K93 A;  5M4P A;  1XFV A;  2JBS A;  3D1I A;  3D9D A;  5K3I A;  2LFW A;  2BTZ A;  3BNG A;  3VKG A;  4XVX A;  4LQQ B;  1FS9 A;  1R3B A;  3GNC A;  4Q4U A;  5K3G A;  3Q24 A;  1X91 A;  2R0N A;  4Q0T A;  3CRL A;  2VIG A;  4E01 A;  1RX0 A;  3X0X A;  4KSF A;  4L1F A;  2RDZ A;  3EON A;  3TZ5 A;  3C3L A;  4FF4 A;  4JEK A;  2FP1 A;  4V26 A;  4AKH A;  2UXW A;  4KTO A;  3TOR A;  4V25 A;  4E00 A;  3AFF A;  1SC5 A;  1Y0V A;  1RP3 A;  2YYL A;  3N0R A;  1Y8P A;  2Q8I A;  3CE2 A;  4MP7 A;  4H81 A;  5GJW E;  5B5V A;  1T9G A;  5BRM A;  1SIR A;  3VAD A;  3M9V A;  2PG0 A;  4H85 A;  2JIF A;  2D29 A;  2BU2 A;  2WBI A;  3MXL A;  2R0M A;  3BNH A;  5K3J A;  2JBR A;  2CJ6 A;  1FS8 A;  2IX6 A;  5J6A A;  2E80 A;  3OWA A;  2VF1 A;  5J71 A;  4JIO A;  4IV6 A;  2EBF X;  4Q5C A;  3TZ0 A;  2ZAF A;  3SXQ A;  4U83 A;  4M9A A;  3VKH A;  2PNR A;  2YGW A;  3EOM A;  3MPI A;  3SWO A;  2E0A A;  2XS1 A;  5M4M A;  3PFD A;  3P4T A;  2BU5 A;  2YYG A;  4HKS A;  3BNJ A;  3RKH A;  2AZE A;  4L3X A;  4G97 A;  3BNF A;  2HJN A;  5M4K A;  1LVC A;  2QR4 A;  4DOY A;  3C46 A;  1UDY A;  2XS8 A;  2PO4 A;  2CJ5 A;  2FP2 A;  4KS9 A;  4X28 C;  3X29 A;  1GKX A;  1BUC A;  3D2R A;  1OAH A;  1PK0 A;  3D9G A;  2ZDY A;  4KSA A;  3C2P A;  1PI1 A;  2BU7 A;  4P79 A;  2RFQ A;  1EGD A;  2C0U A;  3D9F A;  4LQS B;  2IX5 A;  5B5W A;  3NF4 A;  4FF1 A;  2DDH A;  3L1T A;  3HWC A;  1JQI A;  2YYK A;  3MPJ A;  1XG2 B;  4KCF A;  3S7W A;  3MDE A;  2Q8F A;  3TZ2 A;  3UU9 A;  2CJ4 A;  3GM6 A;  2GBB A;  4H7Q A;  1RJ1 A;  3MKH A;  2Z1Q A;  1R2J A;  3D9E A;  4OO2 A;  4Q17 A;  3X0Y A;  1GU6 A;  4L3Y A;  3Q0A A;  4HKR A;  2OR0 A;  4MPN A;  1XFX A;  2CX9 A;  4RM7 A;  4ZXV A;  5M4N A;  2RF7 A;  2R05 A;  5GJV E;  4AKI A;  2ZDX A;  3KML A;  1IVH A;  2OT4 A;  3B96 A;  2YYM A;  1EGC A;  2OEX A;  1U8V A;  1K90 A;  4MP2 A;  4X28 A;  2OJQ A;  3UBR A;  2OEV A;  1QDB A;  1UKW A;  1X90 A;  3LG1 A;  2EBA A;  4HR3 A;  4L38 A;  4WJY A;  4W9U A;  2AO2 A;  5K3H A;  4DZY A;  2A1T A;  3MMO A;  3LGQ A;  4Q1O A;  2J7A A;  4J1V A;  4MPC A;  2FON A;  4E02 A;  4ZYJ A;  1GKZ A;  1XFZ A;  2JBT A;  5B6B A;  5BRK A;  1JM6 A;  2ZO5 A;  2REH A;  4AI6 A;  2R03 A;  4QIC A;  4FF2 A;  4L3Z A;  3F29 A;  4IRN A;  3Q23 A;  3OIB A;  4P13 A;  1Y8O A;  3II9 A;  3D6B A;  2E81 A;  3FCJ A;  2Q8G A;  1S26 A;  2C12 A;  4Q5B A;  2CJ8 A;  3FO3 A;  2DVL A;  3AFE A;  3GQT A;  2VR0 A;  1WS9 A;  1FS7 A;  2BU8 A;  2BU6 A;  3R7K A;  4FF3 A;  2R02 A;  1X8Z A;  4F0X A;  2CJ7 A;  3CRK A;  1XFY A;  1XFU A;  4G5E A;  3SF6 A;  4AKG A;  4O5M A;  2F6L A;  4FZ4 A;  3MDD A;  1Y8N A;  1GJV A;  1IS2 A;  3OWM A;  2YYJ A;  1K8T A;  2Q8H A;  4NXL A;  1SK6 A;  2XQR B; 
#chains in the Genus database with same CATH homology
 5BRK A;  5BRM A;  4JIZ A;  1PI1 A;  4LQQ B;  2HJN A;  5B5V A;  4LQS B;  5B5W A;  1R3B A;  4J1V A;  5B6B A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...