5BRMA

Structural basis for mob1-dependent activation of the core mst-lats kinase cascade in hippo signaling
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
160
structure length
154
Chain Sequence
DLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
pubmed doi rcsb
molecule tags Transferase/signaling protein
source organism Homo sapiens
molecule keywords MOB kinase activator 1A
total genus 52
structure length 154
sequence length 160
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2015-05-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.30 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 MOB kinase activator 5brmA00
5B5WA 2HJNA 4LQQB 5BRKA 4LQSB 5BRMA 4JIZA 5B5VA 4J1VA 1R3BA 1PI1A 5B6BA
chains in the Genus database with same CATH superfamily
4G97A 1SC5A 4V25A 3VKGA 1SK6A 1XFUA 2Q8HA 2E0AA 2JBSA 1LVCA 1EGDA 1Y8OA 2BTZA 1GKXA 4DOYA 2YYLA 4MP2A 1PI1A 5B5WA 2J7AA 3EONA 4M9AA 5K3JA 4Q5BA 3D6BA 2YYKA 2YYIA 2CJ8A 3II9A 4DZYA 2HJNA 3GQTA 1Y8NA 4QICA 2ZKJA 3BNJA 3D9GA 3X0XA 2R0NA 5K3HA 3Q23A 1FS9A 1BUCA 1RP3A 3CE2A 5M4MA 2ZDYA 1RJ4A 2LFWA 1Y8PA 2PNRA 1GU6A 2REHA 4F0XA 3MXLA 3OIBA 1UKWA 2A1TA 1XFWA 4Q1OA 2RDZA 3TZ2A 4WJYA 3C46A 4AKHA 1UDYA 5M4KA 3LGQA 3TZ5A 3KMLA 5BRKA 2ZAFA 3SF6A 2XS8A 2UXWA 2JBRA 4NXLA 3FO3A 4X28C 4AKIA 4AKGA 1XFXA 2OR0A 2RF7A 3MKHA 3OWAA 1EGEA 1PK0A 2VIGA 3D9FA 4Q0TA 2PO4A 2ZO5A 2BU2A 2Z1QA 4HKRA 3RKHA 5B6BA 4L1FA 3S7WA 3LG1A 1JQIA 3BNFA 3Q22A 3C3LA 2BU8A 3F29A 2CJ4A 3AFEA 1R3BA 2CJ6A 2R03A 4MPNA 3C2PA 2XS1A 2C0UA 2YYMA 1S26A 1XFZA 2AO2A 1T9GA 1XFVA 2E80A 5M4NA 2EBHX 4KSAA 2YYJA 1K8TA 2GBBA 3FCJA 4IV6A 4MPEA 4E02A 2Q8GA 4E00A 2AZEA 2BU5A 3MPIA 3VKHA 2ZDXA 3SXQA 3OWMA 3MPJA 2BU7A 2XQRB 1R2JA 2IX6A 1GJVA 3X0YA 2CX9A 4G5EA 3D9DA 4KSFA 1X90A 2JBTA 3D1IA 4IRNA 4LQSB 5K3GA 4L3XA 2WBIA 2YYGA 1XG2B 3MDEA 4J1VA 1FS7A 2VR0A 4L3YA 4U83A 4FF3A 2DDHA 2BU6A 3MDDA 2FP2A 4P13A 2E81A 1IVHA 2PG0A 4Q4UA 3TTBA 3UU9A 3D9EA 4O5MA 3EOMA 4JIZA 4E01A 2Q8IA 4KCFA 1RJ1A 4ZXVA 3GM6A 2OEVA 4KS9A 4Q17A 1U8VA 3TORA 1FS8A 1Y0VA 1K93A 3X29A 2CJ7A 2JIFA 4Q5CA 1GKZA 4FF1A 2R05A 4KTOA 3SWOA 2DVLA 4L3ZA 4FF2A 1SIRA 1W07A 4RM7A 3MMOA 4FF4A 1JM6A 1X8ZA 4P79A 4HR3A 2R02A 2D29A 3NF4A 2EBAA 3TZ0A 3GNCA 2F6LA 3HWCA 3R7KA 1X91A 4H81A 4JEKA 1EGCA 2QR4A 2EBFX 3CRLA 3TZ4A 3VADA 5K3IA 4ZYJA 5J6AA 2OEXA 1OAHA 3BNHA 4W9UA 3Q0AA 3Q24A 4OO2A 2EC5A 2RFQA 3UBRA 2R0MA 2OJQA 2CJ5A 4X28A 3AFFA 2C12A 5M4PA 4L38A 4H85A 5B5VA 2Q8FA 1SIQA 3L1TA 1K90A 2VF1A 3M9VA 5GJWE 4HKSA 2OT4A 4FZ4A 3P4TA 4MPCA 4N5FA 4AI6A 4MP7A 3N0RA 3B96A 4XVXA 5J71A 3PFDA 1WS9A 5BRMA 1IS2A 1QDBA 3BNGA 2FP1A 4H7QA 3CRKA 3D2RA 2IX5A 5GJVE 4LQQB 3SCEA 4JIOA 2FONA 1XFYA 1RX0A 2YGWA 4V26A
chains in the Genus database with same CATH topology
5B5WA 2HJNA 4LQQB 5BRKA 4LQSB 5BRMA 4JIZA 5B5VA 4J1VA 1R3BA 1PI1A 5B6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5B5W A;  2HJN A;  4LQQ B;  5BRK A;  4LQS B;  5BRM A;  4JIZ A;  5B5V A;  4J1V A;  1R3B A;  1PI1 A;  5B6B A; 
#chains in the Genus database with same CATH topology
 4G97 A;  1SC5 A;  4V25 A;  3VKG A;  1SK6 A;  1XFU A;  2Q8H A;  2E0A A;  2JBS A;  1LVC A;  1EGD A;  1Y8O A;  2BTZ A;  1GKX A;  4DOY A;  2YYL A;  4MP2 A;  1PI1 A;  5B5W A;  2J7A A;  3EON A;  4M9A A;  5K3J A;  4Q5B A;  3D6B A;  2YYK A;  2YYI A;  2CJ8 A;  3II9 A;  4DZY A;  2HJN A;  3GQT A;  1Y8N A;  4QIC A;  2ZKJ A;  3BNJ A;  3D9G A;  3X0X A;  2R0N A;  5K3H A;  3Q23 A;  1FS9 A;  1BUC A;  1RP3 A;  3CE2 A;  5M4M A;  2ZDY A;  1RJ4 A;  2LFW A;  1Y8P A;  2PNR A;  1GU6 A;  2REH A;  4F0X A;  3MXL A;  3OIB A;  1UKW A;  2A1T A;  1XFW A;  4Q1O A;  2RDZ A;  3TZ2 A;  4WJY A;  3C46 A;  4AKH A;  1UDY A;  5M4K A;  3LGQ A;  3TZ5 A;  3KML A;  5BRK A;  2ZAF A;  3SF6 A;  2XS8 A;  2UXW A;  2JBR A;  4NXL A;  3FO3 A;  4X28 C;  4AKI A;  4AKG A;  1XFX A;  2OR0 A;  2RF7 A;  3MKH A;  3OWA A;  1EGE A;  1PK0 A;  2VIG A;  3D9F A;  4Q0T A;  2PO4 A;  2ZO5 A;  2BU2 A;  2Z1Q A;  4HKR A;  3RKH A;  5B6B A;  4L1F A;  3S7W A;  3LG1 A;  1JQI A;  3BNF A;  3Q22 A;  3C3L A;  2BU8 A;  3F29 A;  2CJ4 A;  3AFE A;  1R3B A;  2CJ6 A;  2R03 A;  4MPN A;  3C2P A;  2XS1 A;  2C0U A;  2YYM A;  1S26 A;  1XFZ A;  2AO2 A;  1T9G A;  1XFV A;  2E80 A;  5M4N A;  2EBH X;  4KSA A;  2YYJ A;  1K8T A;  2GBB A;  3FCJ A;  4IV6 A;  4MPE A;  4E02 A;  2Q8G A;  4E00 A;  2AZE A;  2BU5 A;  3MPI A;  3VKH A;  2ZDX A;  3SXQ A;  3OWM A;  3MPJ A;  2BU7 A;  2XQR B;  1R2J A;  2IX6 A;  1GJV A;  3X0Y A;  2CX9 A;  4G5E A;  3D9D A;  4KSF A;  1X90 A;  2JBT A;  3D1I A;  4IRN A;  4LQS B;  5K3G A;  4L3X A;  2WBI A;  2YYG A;  1XG2 B;  3MDE A;  4J1V A;  1FS7 A;  2VR0 A;  4L3Y A;  4U83 A;  4FF3 A;  2DDH A;  2BU6 A;  3MDD A;  2FP2 A;  4P13 A;  2E81 A;  1IVH A;  2PG0 A;  4Q4U A;  3TTB A;  3UU9 A;  3D9E A;  4O5M A;  3EOM A;  4JIZ A;  4E01 A;  2Q8I A;  4KCF A;  1RJ1 A;  4ZXV A;  3GM6 A;  2OEV A;  4KS9 A;  4Q17 A;  1U8V A;  3TOR A;  1FS8 A;  1Y0V A;  1K93 A;  3X29 A;  2CJ7 A;  2JIF A;  4Q5C A;  1GKZ A;  4FF1 A;  2R05 A;  4KTO A;  3SWO A;  2DVL A;  4L3Z A;  4FF2 A;  1SIR A;  1W07 A;  4RM7 A;  3MMO A;  4FF4 A;  1JM6 A;  1X8Z A;  4P79 A;  4HR3 A;  2R02 A;  2D29 A;  3NF4 A;  2EBA A;  3TZ0 A;  3GNC A;  2F6L A;  3HWC A;  3R7K A;  1X91 A;  4H81 A;  4JEK A;  1EGC A;  2QR4 A;  2EBF X;  3CRL A;  3TZ4 A;  3VAD A;  5K3I A;  4ZYJ A;  5J6A A;  2OEX A;  1OAH A;  3BNH A;  4W9U A;  3Q0A A;  3Q24 A;  4OO2 A;  2EC5 A;  2RFQ A;  3UBR A;  2R0M A;  2OJQ A;  2CJ5 A;  4X28 A;  3AFF A;  2C12 A;  5M4P A;  4L38 A;  4H85 A;  5B5V A;  2Q8F A;  1SIQ A;  3L1T A;  1K90 A;  2VF1 A;  3M9V A;  5GJW E;  4HKS A;  2OT4 A;  4FZ4 A;  3P4T A;  4MPC A;  4N5F A;  4AI6 A;  4MP7 A;  3N0R A;  3B96 A;  4XVX A;  5J71 A;  3PFD A;  1WS9 A;  5BRM A;  1IS2 A;  1QDB A;  3BNG A;  2FP1 A;  4H7Q A;  3CRK A;  3D2R A;  2IX5 A;  5GJV E;  4LQQ B;  3SCE A;  4JIO A;  2FON A;  1XFY A;  1RX0 A;  2YGW A;  4V26 A; 
#chains in the Genus database with same CATH homology
 5B5W A;  2HJN A;  4LQQ B;  5BRK A;  4LQS B;  5BRM A;  4JIZ A;  5B5V A;  4J1V A;  1R3B A;  1PI1 A;  5B6B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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