1X2JA

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of keap1 on nrf2
Total Genus 69

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
source organism Mus musculus
publication title Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
pubmed doi rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 69
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2005-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 1x2jA00
4ZGCA 4IQKA 3ZGDA 5FNSA 2XN4A 5FNRA 5FNUA 3VNGA 4IFNX 1X2RA 4CHBA 3II7A 3VNHA 3ADEA 3WDZA 4N1BA 2ZZKA 4XMBA 5FZJA 4IFLX 2ZW9A 5FZNA 2WOZA 5CGJA 4L7DA 2Z32A 1X2JA 4IN4A 4ZY3A 4CH9A 1ZGKA 5FNQA 2ZWAA 3ZGCA 5FNTA 4L7BA 4IFJA 2VPJA 4L7CA 2DYHA 1U6DX 3WN7A 5F72C 4ASCA 2FLUX 4YY8A
chains in the Genus database with same CATH superfamily
1L7HA 1W0PA 1Z4YA 2H2NA 2QWKA 3K37A 3ALXA 4XIKA 2W5NA 3SANA 4AHAA 2HTYA 3H72A 4QN5A 1NSCA 4XYXA 3UC1A 4XOGA 2GVWA 1QLGA 2YA4A 3O4PA 1OFZA 4NN9A 4AGIA 4YZ2A 1E8UA 4MC7A 1V0EA 3SREA 3FVZA 4XJAA 1N1TA 2HQSA 1VCUA 2QWIA 4ASCA 4ZLRA 4MWQA 1INGA 2F13A 4JMLA 4FPOB 2SIMA 2XZKA 3VNGA 5HUMA 4MZAA 3AMRA 4KS3A 1W21A 4XMBA 5F9TA 4IFLX 4GNBA 5CGJA 2YA6A 3A71A 4FP3A 4Q6KA 2W5OA 1SO7A 2P4OA 4MWRA 2QWAA 3SILA 1A4GA 1WP5A 2DYHA 1NCCN 1NMCA 4GZPA 2VW0A 4FOQA 3GVKA 4CPMA 4YZ3A 4HZXA 5FNRA 2IAWA 2AH2A 4GZQA 1CRUA 1MS0A 1W1XA 4FPJA 4N1BA 5FZJA 2ZW9A 3ALWA 3BEQA 3TI4A 4XJ9A 3S94A 3K3AA 4Q1UA 1PJXA 2W8BA 1MS4A 1N6EA 4HZVA 2IAVA 1NPEA 2FLUX 3HLIA 3CYEA 5HUGA 1NSBA 3SOBB 1BJIA 4QNPA 4AGTA 2VW2A 2OJHA 2IARA 1L7GA 2ZZKA 3NSSA 2F12A 1SNTA 2WOZA 4WA3A 2XZJA 4CPOA 1Q7FA 2ZWAA 3CKZA 4NC5A 5GX2A 2YA5A 5GX5A 2QE8A 2HT8A 2C4AA 4B7QA 3SOVA 4D52B 1N1VA 3S2KA 5HX0A 4WA5A 2IATA 1IVBA 1E1AA 1CRZA 4DG6A 4D8SA 2XZIA 1EUTA 1SUUA 1N6DA 3NO0A 4CPYA 4C1YA 1Z4XA 1NCBN 2BATA 4FPHA 4GNAA 5FNTA 1E8VA 1W8NA 2VPJA 3WWAA 2C4LA 1V04A 4YW3A 3A9HA 2F25A 1NSDA 2IAPA 1Z50A 2HU4A 3G4EA 5HUKA 2BZDA 2X9MA 3H71A 3PJQA 1E8TA 2VSMA 3GVJA 4J9TA 4HHOA 4FPFA 3VNHA 4DGRA 1MWEA 4PWZA 2SILA 1N6FA 4MWJA 5M1ZA 4D4UA 5FWWA 4UOUA 3O9KA 1W20A 4GN8A 2CMLA 1NCDN 1V2IA 2F11A 4M4UA 5HUNA 4XHXA 4A0PA 4CSDA 1WCSA 3CL2A 1V3DA 4MZEA 4QN4A 1N1YA 2YDPA 3I1CA 1QBIA 3Q6KA 3TI3A 4GJTA 1NNBA 5JYYA 3TIBA 2ZB5A 3HLHA 2FHRA 1F8EA 1F8BA 4M3MA 2IASA 1X2JA 2VSKA 3S8ZA 2GVVA 1IVDA 2QWDA 4MX0A 4X49A 3LI3A 4GZOA 4FZHA 3D12A 1K32A 1USRA 3DR2A 3K36A 4XJZA 4GZTA 3K38A 3OPZA 2QWJA 4B7MA 1Z4ZA 3WW9A 4YZ5A 4ZGCA 3ZGDA 3FW0A 3W09A 4FPKA 2DG1A 5H47A 3K39A 4KS2A 1A4QA 5B2DA 3B7EA 1MS3A 2GVUA 3H73A 3KGGA 1IUBA 2DSOA 2VVZA 2FPBA 4D52A 5FNQA 4YW5A 3INBA 2IAOA 2HT5A 2QWCA 4HHQA 2AEQA 2BF6A 4WA4A 2F26A 1INYA 1IUCA 2HTWA 1IVFA 2YA7A 1INFA 2HTUA 3AMSA 4WEFA 2A75A 4KS1A 3T1EA 1V3CA 4M4NA 2H2UA 1NCAN 1XOGA 5D9CA 4L7DA 2Z32A 4FPLA 4QN6A 1MZ5A 1S18A 4MWLA 2POOA 1V0FA 4NCSA 1NNCA 1INXA 3KYAA 3DASA 4GZWA 1CQ1A 2F29A 3SALA 2YDTA 1MS8A 1W8OA 4BBWA 1S0IA 1CVMA 4FOVA 7NN9A 1V3EA 3WDZA 2BERA 1Z4WA 3Q6TA 5B2CA 2F10A 3O9JA 4CH9A 4MWVA 3TIAA 1MZ6A 1NMBN 2FP9A 3B69A 1IVGA 3LI5A 2F27A 4KS5A 2IVZA 1MR5A 4SLIA 4B7JA 4FOYA 3II7A 3JU4A 4G3NA 1IVEA 1B9VA 1C5KA 5EO7A 4XHBA 5GTQA 4B7NA 1H6LA 1SLIA 3V65B 1ZGKA 4YW2A 3ZGCA 2HU0A 1POOA 1MS9A 4XE9A 4GZXA 4XILA 2QWBA 2SLIA 1INHA 2B8HA 3TI6A 1C9UA 4IYGA 4YY8A 4FJ6A 1S1DA 5D9DA 3NN9A 2HTVA 5FNSA 2XN4A 3LI4A 4YW1A 2QWGA 2FP8A 5EO8A 5D9BA 1MS5A 2VK5A 4HZZA 1X2RA 4FVKA 3TI8A 4FQ4A 2IAQA 4MWUA 4K1KA 1RWLA 5FZNA 2ISMA 2RKCA 1B9TA 2HTQA 1IVCA 1MS1A 3HRPA 4HIZA 4YW4A 2AEPA 5GX3A 4AH4A 6NN9A 4MWYA 4I00A 1V0ZA 4B7RA 4L7CA 1NNAA 3A72A 2FPCA 3WN7A 1DILA 1L7FA 1SLLA 2AGSA 4GN9A 1ZI0A 2DG0A 4C1YB 3H6JA 5GX1A 1S0JA 2VAQA 3L6VA 4CHBA 1XOEA 2HT7A 5GX4A 4FOWA 2QWEA 3SOQA 4GB1A 4QN3A 4CPZA 4IN4A 1KITA 4MWXA 1W0OA 4L7BA 1EURA 2QWFA 5EX7A 2QWHA 3BYCA 4HZYA 1Z4VA 4IMBA 4X4AA 4H52A 4XJ8A 4IQKA 3V1SA 3U0SA 1V3BA 5FNUA 4FPGA 3CL0A 4HW6A 1EUUA 1USXA 2W20A 3IAXA 1INWA 1N7DA 1F8DA 4XIOA 2F24A 2GVXA 4ZY3A 3A9GA 3TI5A 3S8VA 4HZWA 2IAXA 1IJQA 4IFJA 4XJUA 4H53A 4CPLA 5F72C 1DIMA 2YA8A 1RWIA 4GN7A 3TC9A 3P5BL 4M4VA 2VK6A 2VWDA 4GDJA 1INVA 2JKBA 4IFNX 4R40A 4O5TA 3ADEA 2W38A 4K1HA 4X47A 4MWWA 3E5ZA 3TICA 3GVLA 2XCYA 4FPCA 4XJWA 4JF7A 4WEGA 1NMAN 2F28A 4XMIA 4XMAA 1EUSA 4UF7A 1F8CA 4GEZA 1U6DX 4K1JA 4X6KA 4XJRA 2VW1A 5NN9A 2V91A 2G8SA 4MJUA 2IAUA 4K3YA 3Q6PA 4YZ1A 1VCJA 3D11A 4GNCA 2ZB6A 1WCQA 2W8BB 3SLIA 1N1SA 4K1IA 3SRGA 1A14N 4FP2A 1NN2A 4FPEA 4KS4A 4FPYA 2F0ZA 1B9SA 2HTRA 3G4HA 4XJQA 4MJVA 3V64C 4CPNA 2VK7A 4GDIA 4O5SA 4YZ4A 4D52C 2GHSA 4QN7A 4GZSA
chains in the Genus database with same CATH topology
4ZGCA 4IQKA 3ZGDA 5FNSA 2XN4A 5FNRA 5FNUA 3VNGA 4IFNX 1X2RA 4CHBA 3II7A 3VNHA 3ADEA 3WDZA 4N1BA 2ZZKA 4XMBA 5FZJA 4IFLX 2ZW9A 5FZNA 2WOZA 5CGJA 4L7DA 2Z32A 1X2JA 4IN4A 4ZY3A 4CH9A 1ZGKA 5FNQA 2ZWAA 3ZGCA 5FNTA 4L7BA 4IFJA 2VPJA 4L7CA 2DYHA 1U6DX 3WN7A 5F72C 4ASCA 2FLUX 4YY8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZGC A;  4IQK A;  3ZGD A;  5FNS A;  2XN4 A;  5FNR A;  5FNU A;  3VNG A;  4IFN X;  1X2R A;  4CHB A;  3II7 A;  3VNH A;  3ADE A;  3WDZ A;  4N1B A;  2ZZK A;  4XMB A;  5FZJ A;  4IFL X;  2ZW9 A;  5FZN A;  2WOZ A;  5CGJ A;  4L7D A;  2Z32 A;  1X2J A;  4IN4 A;  4ZY3 A;  4CH9 A;  1ZGK A;  5FNQ A;  2ZWA A;  3ZGC A;  5FNT A;  4L7B A;  4IFJ A;  2VPJ A;  4L7C A;  2DYH A;  1U6D X;  3WN7 A;  5F72 C;  4ASC A;  2FLU X;  4YY8 A; 
#chains in the Genus database with same CATH topology
 1L7H A;  1W0P A;  1Z4Y A;  2H2N A;  2QWK A;  3K37 A;  3ALX A;  4XIK A;  2W5N A;  3SAN A;  4AHA A;  2HTY A;  3H72 A;  4QN5 A;  1NSC A;  4XYX A;  3UC1 A;  4XOG A;  2GVW A;  1QLG A;  2YA4 A;  3O4P A;  1OFZ A;  4NN9 A;  4AGI A;  4YZ2 A;  1E8U A;  4MC7 A;  1V0E A;  3SRE A;  3FVZ A;  4XJA A;  1N1T A;  2HQS A;  1VCU A;  2QWI A;  4ASC A;  4ZLR A;  4MWQ A;  1ING A;  2F13 A;  4JML A;  4FPO B;  2SIM A;  2XZK A;  3VNG A;  5HUM A;  4MZA A;  3AMR A;  4KS3 A;  1W21 A;  4XMB A;  5F9T A;  4IFL X;  4GNB A;  5CGJ A;  2YA6 A;  3A71 A;  4FP3 A;  4Q6K A;  2W5O A;  1SO7 A;  2P4O A;  4MWR A;  2QWA A;  3SIL A;  1A4G A;  1WP5 A;  2DYH A;  1NCC N;  1NMC A;  4GZP A;  2VW0 A;  4FOQ A;  3GVK A;  4CPM A;  4YZ3 A;  4HZX A;  5FNR A;  2IAW A;  2AH2 A;  4GZQ A;  1CRU A;  1MS0 A;  1W1X A;  4FPJ A;  4N1B A;  5FZJ A;  2ZW9 A;  3ALW A;  3BEQ A;  3TI4 A;  4XJ9 A;  3S94 A;  3K3A A;  4Q1U A;  1PJX A;  2W8B A;  1MS4 A;  1N6E A;  4HZV A;  2IAV A;  1NPE A;  2FLU X;  3HLI A;  3CYE A;  5HUG A;  1NSB A;  3SOB B;  1BJI A;  4QNP A;  4AGT A;  2VW2 A;  2OJH A;  2IAR A;  1L7G A;  2ZZK A;  3NSS A;  2F12 A;  1SNT A;  2WOZ A;  4WA3 A;  2XZJ A;  4CPO A;  1Q7F A;  2ZWA A;  3CKZ A;  4NC5 A;  5GX2 A;  2YA5 A;  5GX5 A;  2QE8 A;  2HT8 A;  2C4A A;  4B7Q A;  3SOV A;  4D52 B;  1N1V A;  3S2K A;  5HX0 A;  4WA5 A;  2IAT A;  1IVB A;  1E1A A;  1CRZ A;  4DG6 A;  4D8S A;  2XZI A;  1EUT A;  1SUU A;  1N6D A;  3NO0 A;  4CPY A;  4C1Y A;  1Z4X A;  1NCB N;  2BAT A;  4FPH A;  4GNA A;  5FNT A;  1E8V A;  1W8N A;  2VPJ A;  3WWA A;  2C4L A;  1V04 A;  4YW3 A;  3A9H A;  2F25 A;  1NSD A;  2IAP A;  1Z50 A;  2HU4 A;  3G4E A;  5HUK A;  2BZD A;  2X9M A;  3H71 A;  3PJQ A;  1E8T A;  2VSM A;  3GVJ A;  4J9T A;  4HHO A;  4FPF A;  3VNH A;  4DGR A;  1MWE A;  4PWZ A;  2SIL A;  1N6F A;  4MWJ A;  5M1Z A;  4D4U A;  5FWW A;  4UOU A;  3O9K A;  1W20 A;  4GN8 A;  2CML A;  1NCD N;  1V2I A;  2F11 A;  4M4U A;  5HUN A;  4XHX A;  4A0P A;  4CSD A;  1WCS A;  3CL2 A;  1V3D A;  4MZE A;  4QN4 A;  1N1Y A;  2YDP A;  3I1C A;  1QBI A;  3Q6K A;  3TI3 A;  4GJT A;  1NNB A;  5JYY A;  3TIB A;  2ZB5 A;  3HLH A;  2FHR A;  1F8E A;  1F8B A;  4M3M A;  2IAS A;  1X2J A;  2VSK A;  3S8Z A;  2GVV A;  1IVD A;  2QWD A;  4MX0 A;  4X49 A;  3LI3 A;  4GZO A;  4FZH A;  3D12 A;  1K32 A;  1USR A;  3DR2 A;  3K36 A;  4XJZ A;  4GZT A;  3K38 A;  3OPZ A;  2QWJ A;  4B7M A;  1Z4Z A;  3WW9 A;  4YZ5 A;  4ZGC A;  3ZGD A;  3FW0 A;  3W09 A;  4FPK A;  2DG1 A;  5H47 A;  3K39 A;  4KS2 A;  1A4Q A;  5B2D A;  3B7E A;  1MS3 A;  2GVU A;  3H73 A;  3KGG A;  1IUB A;  2DSO A;  2VVZ A;  2FPB A;  4D52 A;  5FNQ A;  4YW5 A;  3INB A;  2IAO A;  2HT5 A;  2QWC A;  4HHQ A;  2AEQ A;  2BF6 A;  4WA4 A;  2F26 A;  1INY A;  1IUC A;  2HTW A;  1IVF A;  2YA7 A;  1INF A;  2HTU A;  3AMS A;  4WEF A;  2A75 A;  4KS1 A;  3T1E A;  1V3C A;  4M4N A;  2H2U A;  1NCA N;  1XOG A;  5D9C A;  4L7D A;  2Z32 A;  4FPL A;  4QN6 A;  1MZ5 A;  1S18 A;  4MWL A;  2POO A;  1V0F A;  4NCS A;  1NNC A;  1INX A;  3KYA A;  3DAS A;  4GZW A;  1CQ1 A;  2F29 A;  3SAL A;  2YDT A;  1MS8 A;  1W8O A;  4BBW A;  1S0I A;  1CVM A;  4FOV A;  7NN9 A;  1V3E A;  3WDZ A;  2BER A;  1Z4W A;  3Q6T A;  5B2C A;  2F10 A;  3O9J A;  4CH9 A;  4MWV A;  3TIA A;  1MZ6 A;  1NMB N;  2FP9 A;  3B69 A;  1IVG A;  3LI5 A;  2F27 A;  4KS5 A;  2IVZ A;  1MR5 A;  4SLI A;  4B7J A;  4FOY A;  3II7 A;  3JU4 A;  4G3N A;  1IVE A;  1B9V A;  1C5K A;  5EO7 A;  4XHB A;  5GTQ A;  4B7N A;  1H6L A;  1SLI A;  3V65 B;  1ZGK A;  4YW2 A;  3ZGC A;  2HU0 A;  1POO A;  1MS9 A;  4XE9 A;  4GZX A;  4XIL A;  2QWB A;  2SLI A;  1INH A;  2B8H A;  3TI6 A;  1C9U A;  4IYG A;  4YY8 A;  4FJ6 A;  1S1D A;  5D9D A;  3NN9 A;  2HTV A;  5FNS A;  2XN4 A;  3LI4 A;  4YW1 A;  2QWG A;  2FP8 A;  5EO8 A;  5D9B A;  1MS5 A;  2VK5 A;  4HZZ A;  1X2R A;  4FVK A;  3TI8 A;  4FQ4 A;  2IAQ A;  4MWU A;  4K1K A;  1RWL A;  5FZN A;  2ISM A;  2RKC A;  1B9T A;  2HTQ A;  1IVC A;  1MS1 A;  3HRP A;  4HIZ A;  4YW4 A;  2AEP A;  5GX3 A;  4AH4 A;  6NN9 A;  4MWY A;  4I00 A;  1V0Z A;  4B7R A;  4L7C A;  1NNA A;  3A72 A;  2FPC A;  3WN7 A;  1DIL A;  1L7F A;  1SLL A;  2AGS A;  4GN9 A;  1ZI0 A;  2DG0 A;  4C1Y B;  3H6J A;  5GX1 A;  1S0J A;  2VAQ A;  3L6V A;  4CHB A;  1XOE A;  2HT7 A;  5GX4 A;  4FOW A;  2QWE A;  3SOQ A;  4GB1 A;  4QN3 A;  4CPZ A;  4IN4 A;  1KIT A;  4MWX A;  1W0O A;  4L7B A;  1EUR A;  2QWF A;  5EX7 A;  2QWH A;  3BYC A;  4HZY A;  1Z4V A;  4IMB A;  4X4A A;  4H52 A;  4XJ8 A;  4IQK A;  3V1S A;  3U0S A;  1V3B A;  5FNU A;  4FPG A;  3CL0 A;  4HW6 A;  1EUU A;  1USX A;  2W20 A;  3IAX A;  1INW A;  1N7D A;  1F8D A;  4XIO A;  2F24 A;  2GVX A;  4ZY3 A;  3A9G A;  3TI5 A;  3S8V A;  4HZW A;  2IAX A;  1IJQ A;  4IFJ A;  4XJU A;  4H53 A;  4CPL A;  5F72 C;  1DIM A;  2YA8 A;  1RWI A;  4GN7 A;  3TC9 A;  3P5B L;  4M4V A;  2VK6 A;  2VWD A;  4GDJ A;  1INV A;  2JKB A;  4IFN X;  4R40 A;  4O5T A;  3ADE A;  2W38 A;  4K1H A;  4X47 A;  4MWW A;  3E5Z A;  3TIC A;  3GVL A;  2XCY A;  4FPC A;  4XJW A;  4JF7 A;  4WEG A;  1NMA N;  2F28 A;  4XMI A;  4XMA A;  1EUS A;  4UF7 A;  1F8C A;  4GEZ A;  1U6D X;  4K1J A;  4X6K A;  4XJR A;  2VW1 A;  5NN9 A;  2V91 A;  2G8S A;  4MJU A;  2IAU A;  4K3Y A;  3Q6P A;  4YZ1 A;  1VCJ A;  3D11 A;  4GNC A;  2ZB6 A;  1WCQ A;  2W8B B;  3SLI A;  1N1S A;  4K1I A;  3SRG A;  1A14 N;  4FP2 A;  1NN2 A;  4FPE A;  4KS4 A;  4FPY A;  2F0Z A;  1B9S A;  2HTR A;  3G4H A;  4XJQ A;  4MJV A;  3V64 C;  4CPN A;  2VK7 A;  4GDI A;  4O5S A;  4YZ4 A;  4D52 C;  2GHS A;  4QN7 A;  4GZS A; 
#chains in the Genus database with same CATH homology
 4ZGC A;  4IQK A;  3ZGD A;  5FNS A;  2XN4 A;  5FNR A;  5FNU A;  3VNG A;  4IFN X;  1X2R A;  4CHB A;  3II7 A;  3VNH A;  3ADE A;  3WDZ A;  4N1B A;  2ZZK A;  4XMB A;  5FZJ A;  4IFL X;  2ZW9 A;  5FZN A;  2WOZ A;  5CGJ A;  4L7D A;  2Z32 A;  1X2J A;  4IN4 A;  4ZY3 A;  4CH9 A;  1ZGK A;  5FNQ A;  2ZWA A;  3ZGC A;  5FNT A;  4L7B A;  4IFJ A;  2VPJ A;  4L7C A;  2DYH A;  1U6D X;  3WN7 A;  5F72 C;  4ASC A;  2FLU X;  4YY8 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

Application loaded.