1X2JA

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of keap1 on nrf2
Total Genus 69

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
source organism Mus musculus
publication title Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
pubmed doi rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 69
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2005-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 1x2jA00
2XN4A 4L7CA 4CHBA 1X2JA 5FNSA 5FZNA 1ZGKA 3II7A 4IFNX 2ZWAA 4N1BA 5F72C 5FNTA 4ZGCA 2DYHA 3WDZA 5FNUA 4IFLX 3ZGCA 4L7BA 5FZJA 2Z32A 2FLUX 3ADEA 1U6DX 2WOZA 2ZW9A 3VNGA 3ZGDA 4YY8A 4IN4A 4L7DA 5FNQA 2ZZKA 4ZY3A 5CGJA 3VNHA 1X2RA 2VPJA 4IQKA 4XMBA 4CH9A 3WN7A 4ASCA 4IFJA 5FNRA
chains in the Genus database with same CATH superfamily
2XN4A 3G4EA 2VSKA 4GZTA 3TI5A 4FOVA 3A9GA 3WW9A 2QWAA 1NMCA 5EO8A 2ZWAA 3O4PA 2SLIA 5GTQA 4FZHA 4D8SA 5B2CA 2HT5A 4YY8A 2WOZA 4XJRA 3DASA 3HRPA 2JKBA 3A71A 1N6DA 5M1ZA 4QN4A 2DG1A 1SNTA 2F26A 1X2JA 4FOYA 3L6VA 1SLLA 4FJ6A 2BF6A 4B7QA 1F8BA 4H52A 1CRZA 3ALWA 3DR2A 2W5OA 2SIMA 3GVKA 2QWKA 4GB1A 1NSCA 4HHQA 4CPLA 1SUUA 4HW6A 1N1TA 3B69A 2A75A 4MC7A 3O9KA 5FNQA 2DG0A 2QWDA 3TIBA 5CGJA 3LI3A 1B9SA 3H73A 1V0EA 4KS5A 4C1YA 1L7FA 1X2RA 4MWYA 4FPCA 4XMAA 4FQ4A 2F12A 1MWEA 2GVWA 1NN2A 1NPEA 1MS4A 2B8HA 1B9TA 5GX1A 4GEZA 1ZGKA 5JYYA 2IAOA 4MJVA 3KGGA 3K36A 4L7BA 4R40A 5FWWA 3U0SA 3V65B 5HUNA 4SLIA 2AGSA 3ZGDA 2RKCA 1NMAN 1S0JA 1XOGA 1S1DA 2QWCA 4L7DA 1SO7A 4QN3A 2HU4A 4O5SA 2XZKA 2F0ZA 3Q6TA 4GN7A 4D52B 4AHAA 3H71A 1Z4XA 4JMLA 4MWLA 1OFZA 2VW0A 1INGA 4L7CA 5HUMA 4FPOB 4MWJA 1IVBA 4FPJA 5FNTA 2DSOA 3GVLA 5EX7A 4FPLA 4KS4A 4O5TA 1L7HA 1MS5A 4MZAA 1Z50A 4MWVA 4ZLRA 4X6KA 2QWFA 4WA4A 1W20A 3KYAA 4QN6A 4YZ5A 3V64C 4NN9A 4GJTA 3G4HA 4KS3A 1N6EA 1MS0A 2YA7A 4K1HA 1NCDN 5FZNA 3T1EA 4XHBA 1W8NA 4FP2A 4M3MA 1NNBA 2DYHA 2QE8A 4CPMA 4IFLX 4ZGCA 2QWIA 4XOGA 2YDTA 3BEQA 4YZ3A 4QNPA 2V91A 2VWDA 4FPFA 4XHXA 1U6DX 4HZZA 3S2KA 1IUBA 2QWEA 1NSBA 4GZPA 4CH9A 4MJUA 4XMBA 2F24A 4NC5A 1C9UA 4FPKA 2P4OA 4CSDA 2YDPA 4B7JA 3S8VA 2X9MA 2BERA 1N7DA 4XIOA 1RWLA 1E1AA 2VK6A 2W20A 4XMIA 2F25A 5EO7A 2C4AA 2XCYA 2SILA 1VCUA 1POOA 2FLUX 1IVFA 2GVVA 4MWWA 2FPCA 2OJHA 1N1VA 1INWA 2CMLA 3VNHA 1IJQA 1L7GA 2VPJA 3HLIA 4FPYA 4IFJA 2IAPA 4GNCA 4XJ9A 5GX4A 4K1IA 4GZOA 2GHSA 4HZYA 1SLIA 3PJQA 1IUCA 1N1SA 1USXA 4IFNX 4KS1A 1IVGA 2IATA 4WA3A 2VK7A 5HUKA 2GVUA 3FVZA 1E8UA 4YW5A 4D52C 2Z32A 2ZW9A 1F8CA 4FPEA 3LI4A 4HZXA 1Z4YA 4K3YA 1Q7FA 2HTVA 5GX3A 4C1YB 1MZ6A 1V0FA 4GNAA 1S18A 1A4QA 1K32A 5D9CA 1MS8A 1BJIA 4HIZA 3SANA 1DILA 7NN9A 1NSDA 2YA4A 4UF7A 2HTWA 2BZDA 1A14N 5FZJA 3D12A 1IVEA 4M4NA 4YZ1A 4X47A 4XJ8A 1F8DA 4GZWA 4XJQA 4MWQA 2IAUA 5F9TA 3TI4A 1S0IA 3Q6KA 5NN9A 1NCBN 1E8VA 3WWAA 5GX2A 2POOA 3O9JA 4D4UA 1ZI0A 4B7MA 1V3DA 1W0OA 2XZJA 3I1CA 4GZQA 5B2DA 3AMSA 3S8ZA 4GNBA 3UC1A 2QWJA 2HU0A 1NNAA 1W21A 3FW0A 2QWGA 4CPNA 5D9BA 4FVKA 1N6FA 2F29A 1INFA 2W8BA 3H6JA 1CQ1A 1V3EA 3K37A 4XILA 3P5BL 3SILA 3SOVA 2W38A 4B7NA 4FOQA 3A72A 4FPHA 6NN9A 4H53A 4A0PA 3INBA 3GVJA 2VAQA 3ADEA 2VSMA 4DGRA 2VVZA 4FOWA 3OPZA 1WCQA 2F13A 2IAVA 3TI6A 4X49A 2HTRA 4IQKA 1VCJA 2HT8A 4YW3A 2FPBA 1WP5A 2FHRA 4PWZA 4WEFA 3JU4A 2IAXA 2FP9A 2QWHA 1CRUA 3CKZA 3V1SA 4XJWA 4G3NA 4K1JA 3WDZA 2IAQA 1B9VA 3TI3A 4XE9A 1V0ZA 1E8TA 4YW4A 1W0PA 2G8SA 4Q6KA 4FPGA 2AH2A 4HZWA 1W8OA 3SLIA 1CVMA 4QN5A 4IN4A 1H6LA 2IARA 4MWUA 2ZZKA 4ZY3A 1EUTA 5HX0A 4Q1UA 3WN7A 1EURA 2IAWA 1W1XA 2IASA 3SRGA 4CHBA 4AGTA 2FP8A 2XZIA 2IVZA 5HUGA 2VK5A 2F28A 4MWRA 4QN7A 3K39A 3ZGCA 3ALXA 1V3BA 3Q6PA 4GZXA 4NCSA 4GDIA 1KITA 2VW1A 1Z4WA 3TC9A 3VNGA 2AEPA 1INYA 2HTYA 2C4LA 3H72A 3AMRA 4FP3A 4M4VA 4XYXA 4B7RA 1MS1A 2VW2A 5D9DA 2AEQA 2YA8A 1Z4ZA 1IVDA 4J9TA 4AGIA 4KS2A 4YW1A 4CPZA 1PJXA 1MS3A 3K3AA 3S94A 2YA6A 1QBIA 3LI5A 2ZB5A 1NCAN 1V3CA 2HTQA 4HHOA 4MWXA 1INVA 3SOQA 1NMBN 4IYGA 4CPOA 2F11A 2ISMA 2YA5A 3TI8A 1NCCN 1XOEA 1USRA 4WA5A 4YZ2A 4CPYA 4JF7A 2H2UA 1NNCA 4XJZA 3CL0A 1MR5A 1MZ5A 3A9HA 5GX5A 3SALA 1EUUA 4N1BA 5F72C 3E5ZA 3D11A 3IAXA 4GN8A 1V2IA 1N1YA 4HZVA 4D52A 4IMBA 1A4GA 2GVXA 1INXA 4GZSA 4GDJA 2W8BB 4WEGA 2W5NA 3NO0A 3K38A 1F8EA 4I00A 1INHA 3TICA 3W09A 4MX0A 3SREA 5FNUA 3CL2A 2HT7A 1QLGA 3SOBB 2BATA 3B7EA 4X4AA 4UOUA 2H2NA 1DIMA 3NSSA 1EUSA 4K1KA 1IVCA 4ASCA 3TIAA 5FNRA 1RWIA 4YW2A 2F27A 4BBWA 4GN9A 5FNSA 3BYCA 1V04A 3II7A 3NN9A 2ZB6A 1WCSA 1C5KA 2HTUA 2F10A 4DG6A 1Z4VA 4AH4A 4MZEA 4M4UA 4XJAA 1MS9A 3CYEA 4YZ4A 2QWBA 4XIKA 3HLHA 2HQSA 5H47A 4XJUA
chains in the Genus database with same CATH topology
2XN4A 4L7CA 4CHBA 1X2JA 5FNSA 5FZNA 1ZGKA 3II7A 4IFNX 2ZWAA 4N1BA 5F72C 5FNTA 4ZGCA 2DYHA 3WDZA 5FNUA 4IFLX 3ZGCA 4L7BA 5FZJA 2Z32A 2FLUX 3ADEA 1U6DX 2WOZA 2ZW9A 3VNGA 3ZGDA 4YY8A 4IN4A 4L7DA 5FNQA 2ZZKA 4ZY3A 5CGJA 3VNHA 1X2RA 2VPJA 4IQKA 4XMBA 4CH9A 3WN7A 4ASCA 4IFJA 5FNRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XN4 A;  4L7C A;  4CHB A;  1X2J A;  5FNS A;  5FZN A;  1ZGK A;  3II7 A;  4IFN X;  2ZWA A;  4N1B A;  5F72 C;  5FNT A;  4ZGC A;  2DYH A;  3WDZ A;  5FNU A;  4IFL X;  3ZGC A;  4L7B A;  5FZJ A;  2Z32 A;  2FLU X;  3ADE A;  1U6D X;  2WOZ A;  2ZW9 A;  3VNG A;  3ZGD A;  4YY8 A;  4IN4 A;  4L7D A;  5FNQ A;  2ZZK A;  4ZY3 A;  5CGJ A;  3VNH A;  1X2R A;  2VPJ A;  4IQK A;  4XMB A;  4CH9 A;  3WN7 A;  4ASC A;  4IFJ A;  5FNR A; 
#chains in the Genus database with same CATH topology
 2XN4 A;  3G4E A;  2VSK A;  4GZT A;  3TI5 A;  4FOV A;  3A9G A;  3WW9 A;  2QWA A;  1NMC A;  5EO8 A;  2ZWA A;  3O4P A;  2SLI A;  5GTQ A;  4FZH A;  4D8S A;  5B2C A;  2HT5 A;  4YY8 A;  2WOZ A;  4XJR A;  3DAS A;  3HRP A;  2JKB A;  3A71 A;  1N6D A;  5M1Z A;  4QN4 A;  2DG1 A;  1SNT A;  2F26 A;  1X2J A;  4FOY A;  3L6V A;  1SLL A;  4FJ6 A;  2BF6 A;  4B7Q A;  1F8B A;  4H52 A;  1CRZ A;  3ALW A;  3DR2 A;  2W5O A;  2SIM A;  3GVK A;  2QWK A;  4GB1 A;  1NSC A;  4HHQ A;  4CPL A;  1SUU A;  4HW6 A;  1N1T A;  3B69 A;  2A75 A;  4MC7 A;  3O9K A;  5FNQ A;  2DG0 A;  2QWD A;  3TIB A;  5CGJ A;  3LI3 A;  1B9S A;  3H73 A;  1V0E A;  4KS5 A;  4C1Y A;  1L7F A;  1X2R A;  4MWY A;  4FPC A;  4XMA A;  4FQ4 A;  2F12 A;  1MWE A;  2GVW A;  1NN2 A;  1NPE A;  1MS4 A;  2B8H A;  1B9T A;  5GX1 A;  4GEZ A;  1ZGK A;  5JYY A;  2IAO A;  4MJV A;  3KGG A;  3K36 A;  4L7B A;  4R40 A;  5FWW A;  3U0S A;  3V65 B;  5HUN A;  4SLI A;  2AGS A;  3ZGD A;  2RKC A;  1NMA N;  1S0J A;  1XOG A;  1S1D A;  2QWC A;  4L7D A;  1SO7 A;  4QN3 A;  2HU4 A;  4O5S A;  2XZK A;  2F0Z A;  3Q6T A;  4GN7 A;  4D52 B;  4AHA A;  3H71 A;  1Z4X A;  4JML A;  4MWL A;  1OFZ A;  2VW0 A;  1ING A;  4L7C A;  5HUM A;  4FPO B;  4MWJ A;  1IVB A;  4FPJ A;  5FNT A;  2DSO A;  3GVL A;  5EX7 A;  4FPL A;  4KS4 A;  4O5T A;  1L7H A;  1MS5 A;  4MZA A;  1Z50 A;  4MWV A;  4ZLR A;  4X6K A;  2QWF A;  4WA4 A;  1W20 A;  3KYA A;  4QN6 A;  4YZ5 A;  3V64 C;  4NN9 A;  4GJT A;  3G4H A;  4KS3 A;  1N6E A;  1MS0 A;  2YA7 A;  4K1H A;  1NCD N;  5FZN A;  3T1E A;  4XHB A;  1W8N A;  4FP2 A;  4M3M A;  1NNB A;  2DYH A;  2QE8 A;  4CPM A;  4IFL X;  4ZGC A;  2QWI A;  4XOG A;  2YDT A;  3BEQ A;  4YZ3 A;  4QNP A;  2V91 A;  2VWD A;  4FPF A;  4XHX A;  1U6D X;  4HZZ A;  3S2K A;  1IUB A;  2QWE A;  1NSB A;  4GZP A;  4CH9 A;  4MJU A;  4XMB A;  2F24 A;  4NC5 A;  1C9U A;  4FPK A;  2P4O A;  4CSD A;  2YDP A;  4B7J A;  3S8V A;  2X9M A;  2BER A;  1N7D A;  4XIO A;  1RWL A;  1E1A A;  2VK6 A;  2W20 A;  4XMI A;  2F25 A;  5EO7 A;  2C4A A;  2XCY A;  2SIL A;  1VCU A;  1POO A;  2FLU X;  1IVF A;  2GVV A;  4MWW A;  2FPC A;  2OJH A;  1N1V A;  1INW A;  2CML A;  3VNH A;  1IJQ A;  1L7G A;  2VPJ A;  3HLI A;  4FPY A;  4IFJ A;  2IAP A;  4GNC A;  4XJ9 A;  5GX4 A;  4K1I A;  4GZO A;  2GHS A;  4HZY A;  1SLI A;  3PJQ A;  1IUC A;  1N1S A;  1USX A;  4IFN X;  4KS1 A;  1IVG A;  2IAT A;  4WA3 A;  2VK7 A;  5HUK A;  2GVU A;  3FVZ A;  1E8U A;  4YW5 A;  4D52 C;  2Z32 A;  2ZW9 A;  1F8C A;  4FPE A;  3LI4 A;  4HZX A;  1Z4Y A;  4K3Y A;  1Q7F A;  2HTV A;  5GX3 A;  4C1Y B;  1MZ6 A;  1V0F A;  4GNA A;  1S18 A;  1A4Q A;  1K32 A;  5D9C A;  1MS8 A;  1BJI A;  4HIZ A;  3SAN A;  1DIL A;  7NN9 A;  1NSD A;  2YA4 A;  4UF7 A;  2HTW A;  2BZD A;  1A14 N;  5FZJ A;  3D12 A;  1IVE A;  4M4N A;  4YZ1 A;  4X47 A;  4XJ8 A;  1F8D A;  4GZW A;  4XJQ A;  4MWQ A;  2IAU A;  5F9T A;  3TI4 A;  1S0I A;  3Q6K A;  5NN9 A;  1NCB N;  1E8V A;  3WWA A;  5GX2 A;  2POO A;  3O9J A;  4D4U A;  1ZI0 A;  4B7M A;  1V3D A;  1W0O A;  2XZJ A;  3I1C A;  4GZQ A;  5B2D A;  3AMS A;  3S8Z A;  4GNB A;  3UC1 A;  2QWJ A;  2HU0 A;  1NNA A;  1W21 A;  3FW0 A;  2QWG A;  4CPN A;  5D9B A;  4FVK A;  1N6F A;  2F29 A;  1INF A;  2W8B A;  3H6J A;  1CQ1 A;  1V3E A;  3K37 A;  4XIL A;  3P5B L;  3SIL A;  3SOV A;  2W38 A;  4B7N A;  4FOQ A;  3A72 A;  4FPH A;  6NN9 A;  4H53 A;  4A0P A;  3INB A;  3GVJ A;  2VAQ A;  3ADE A;  2VSM A;  4DGR A;  2VVZ A;  4FOW A;  3OPZ A;  1WCQ A;  2F13 A;  2IAV A;  3TI6 A;  4X49 A;  2HTR A;  4IQK A;  1VCJ A;  2HT8 A;  4YW3 A;  2FPB A;  1WP5 A;  2FHR A;  4PWZ A;  4WEF A;  3JU4 A;  2IAX A;  2FP9 A;  2QWH A;  1CRU A;  3CKZ A;  3V1S A;  4XJW A;  4G3N A;  4K1J A;  3WDZ A;  2IAQ A;  1B9V A;  3TI3 A;  4XE9 A;  1V0Z A;  1E8T A;  4YW4 A;  1W0P A;  2G8S A;  4Q6K A;  4FPG A;  2AH2 A;  4HZW A;  1W8O A;  3SLI A;  1CVM A;  4QN5 A;  4IN4 A;  1H6L A;  2IAR A;  4MWU A;  2ZZK A;  4ZY3 A;  1EUT A;  5HX0 A;  4Q1U A;  3WN7 A;  1EUR A;  2IAW A;  1W1X A;  2IAS A;  3SRG A;  4CHB A;  4AGT A;  2FP8 A;  2XZI A;  2IVZ A;  5HUG A;  2VK5 A;  2F28 A;  4MWR A;  4QN7 A;  3K39 A;  3ZGC A;  3ALX A;  1V3B A;  3Q6P A;  4GZX A;  4NCS A;  4GDI A;  1KIT A;  2VW1 A;  1Z4W A;  3TC9 A;  3VNG A;  2AEP A;  1INY A;  2HTY A;  2C4L A;  3H72 A;  3AMR A;  4FP3 A;  4M4V A;  4XYX A;  4B7R A;  1MS1 A;  2VW2 A;  5D9D A;  2AEQ A;  2YA8 A;  1Z4Z A;  1IVD A;  4J9T A;  4AGI A;  4KS2 A;  4YW1 A;  4CPZ A;  1PJX A;  1MS3 A;  3K3A A;  3S94 A;  2YA6 A;  1QBI A;  3LI5 A;  2ZB5 A;  1NCA N;  1V3C A;  2HTQ A;  4HHO A;  4MWX A;  1INV A;  3SOQ A;  1NMB N;  4IYG A;  4CPO A;  2F11 A;  2ISM A;  2YA5 A;  3TI8 A;  1NCC N;  1XOE A;  1USR A;  4WA5 A;  4YZ2 A;  4CPY A;  4JF7 A;  2H2U A;  1NNC A;  4XJZ A;  3CL0 A;  1MR5 A;  1MZ5 A;  3A9H A;  5GX5 A;  3SAL A;  1EUU A;  4N1B A;  5F72 C;  3E5Z A;  3D11 A;  3IAX A;  4GN8 A;  1V2I A;  1N1Y A;  4HZV A;  4D52 A;  4IMB A;  1A4G A;  2GVX A;  1INX A;  4GZS A;  4GDJ A;  2W8B B;  4WEG A;  2W5N A;  3NO0 A;  3K38 A;  1F8E A;  4I00 A;  1INH A;  3TIC A;  3W09 A;  4MX0 A;  3SRE A;  5FNU A;  3CL2 A;  2HT7 A;  1QLG A;  3SOB B;  2BAT A;  3B7E A;  4X4A A;  4UOU A;  2H2N A;  1DIM A;  3NSS A;  1EUS A;  4K1K A;  1IVC A;  4ASC A;  3TIA A;  5FNR A;  1RWI A;  4YW2 A;  2F27 A;  4BBW A;  4GN9 A;  5FNS A;  3BYC A;  1V04 A;  3II7 A;  3NN9 A;  2ZB6 A;  1WCS A;  1C5K A;  2HTU A;  2F10 A;  4DG6 A;  1Z4V A;  4AH4 A;  4MZE A;  4M4U A;  4XJA A;  1MS9 A;  3CYE A;  4YZ4 A;  2QWB A;  4XIK A;  3HLH A;  2HQS A;  5H47 A;  4XJU A; 
#chains in the Genus database with same CATH homology
 2XN4 A;  4L7C A;  4CHB A;  1X2J A;  5FNS A;  5FZN A;  1ZGK A;  3II7 A;  4IFN X;  2ZWA A;  4N1B A;  5F72 C;  5FNT A;  4ZGC A;  2DYH A;  3WDZ A;  5FNU A;  4IFL X;  3ZGC A;  4L7B A;  5FZJ A;  2Z32 A;  2FLU X;  3ADE A;  1U6D X;  2WOZ A;  2ZW9 A;  3VNG A;  3ZGD A;  4YY8 A;  4IN4 A;  4L7D A;  5FNQ A;  2ZZK A;  4ZY3 A;  5CGJ A;  3VNH A;  1X2R A;  2VPJ A;  4IQK A;  4XMB A;  4CH9 A;  3WN7 A;  4ASC A;  4IFJ A;  5FNR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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