4XMBA

Crystal structure of 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetamide bound to human keap1 kelch domain
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
286
structure length
286
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
molecule keywords Kelch-like ECH-associated protein 1
publication title Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
pubmed doi rcsb
source organism Homo sapiens
total genus 64
structure length 286
sequence length 286
ec nomenclature
pdb deposition date 2015-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4xmbA00
5FZJA 3ZGDA 4ZGCA 1ZGKA 2XN4A 4N1BA 3ADEA 5FNTA 5FZNA 4IN4A 5CGJA 3WDZA 2Z32A 3WN7A 2DYHA 5FNRA 4XMBA 3VNGA 5FNUA 4L7BA 2WOZA 4IFNX 2FLUX 3II7A 4IFJA 4L7DA 1U6DX 2VPJA 2ZZKA 4L7CA 1X2JA 4ZY3A 3VNHA 2ZW9A 3ZGCA 4IQKA 5FNQA 5FNSA 4IFLX 4CHBA 1X2RA 5F72C 2ZWAA 4CH9A 4ASCA 4YY8A
chains in the Genus database with same CATH superfamily
2XN4A 4CPLA 4N1BA 3HLIA 1F8DA 3WDZA 4FOQA 3V1SA 4BBWA 2BERA 3WWAA 2IVZA 4M4UA 1XOGA 2HTQA 1V3CA 2G8SA 2HU4A 2QWAA 3H72A 3LI3A 4QN3A 4I00A 4M3MA 1MS4A 4ZY3A 3Q6TA 4XILA 3LI4A 3SANA 2ZW9A 4GN9A 4HZZA 4XJ9A 4HZVA 3NSSA 4CPYA 1NPEA 2QWKA 4FPJA 1W21A 3CYEA 4MZEA 2XCYA 3O9JA 4M4NA 4GZOA 4CPMA 4YZ4A 2VW1A 4CPNA 4D52C 4XHBA 4IMBA 4X47A 1RWIA 2FPCA 1INFA 1N1YA 1X2JA 3NO0A 5D9DA 3S2KA 1Z4WA 3Q6PA 3D11A 3PJQA 4FP2A 4GZPA 3TI4A 1ZGKA 2W5OA 4MWYA 1NSCA 2IAQA 1W0OA 1MS3A 2YA6A 1N6FA 1KITA 4O5SA 2F26A 4YW3A 3KGGA 1E8UA 1MS1A 4GNBA 5NN9A 5HUKA 1Z4YA 2F11A 3K39A 1INVA 3B7EA 1ZI0A 4IFLX 3G4EA 2C4AA 3GVLA 1WCSA 2HTVA 1OFZA 3A71A 5EO7A 4WEGA 1MR5A 4K3YA 4HHQA 4FJ6A 1IVFA 1N6EA 1IVGA 3IAXA 4FPGA 3SOBB 3V64C 4UF7A 4QN4A 3G4HA 5HUGA 5HUNA 2DG1A 1XOEA 4KS4A 5FNUA 2QWEA 3TC9A 2FLUX 3HRPA 4FOYA 5F9TA 5D9BA 1N1VA 1WCQA 1Q7FA 1V0ZA 4DGRA 2HTRA 5H47A 1INHA 2ZWAA 1SUUA 4MWLA 2GVWA 4XJ8A 3SREA 3CL0A 1NSBA 3ADEA 2F29A 2AEPA 4WA5A 4FPLA 1DIMA 4XJAA 2VAQA 1POOA 1A4GA 4QN7A 1IJQA 4J9TA 4QN6A 3L6VA 4XHXA 3SOQA 3ZGCA 3U0SA 1C5KA 4CH9A 5GX4A 4CPZA 2QWHA 2VK7A 1WP5A 2VVZA 1MZ6A 3W09A 2SILA 4XJZA 4D8SA 1SLIA 1Z4XA 5FZNA 1NSDA 4FOVA 4B7QA 2FPBA 4JMLA 4FOWA 1V3DA 4YW2A 4YZ3A 4GZWA 4MWVA 2QWBA 2IAVA 3VNGA 1V0FA 2BATA 1MS5A 2HQSA 2WOZA 1MS8A 2HTUA 4MX0A 3VNHA 4QN5A 2V91A 4Q6KA 4GZTA 3TIAA 4CHBA 2QWGA 1E1AA 1NMAN 1CRZA 3A72A 4XIOA 4YZ5A 3NN9A 2F0ZA 4ZGCA 5HX0A 2F13A 1PJXA 4IN4A 4KS5A 4X4AA 4MC7A 1B9VA 3SRGA 3JU4A 1IUCA 4UOUA 1NNCA 2VW2A 2HT5A 2BF6A 3SILA 1SNTA 2RKCA 4MWRA 4B7RA 4M4VA 1NCDN 4L7DA 5B2DA 2ZZKA 4XOGA 4MJUA 3K3AA 2VW0A 1MWEA 2GVVA 2W5NA 2QWDA 4AHAA 3FVZA 3BEQA 2JKBA 2F12A 2IAWA 3TICA 2CMLA 1E8TA 1MS9A 2AEQA 4MWUA 2IAOA 2H2NA 3T1EA 4L7BA 3Q6KA 2YDTA 2QWIA 1S0JA 2POOA 4FPFA 4GN8A 4MZAA 2AH2A 4KS1A 4GNAA 1V2IA 5GTQA 2W8BB 3UC1A 1Z50A 1X2RA 2X9MA 5FZJA 4B7NA 7NN9A 1IUBA 4H53A 1VCJA 4XE9A 4XJWA 3H6JA 4IYGA 3OPZA 3TIBA 3WN7A 2W8BA 1VCUA 1NCAN 4DG6A 1INWA 4XMAA 1L7HA 2F10A 2B8HA 5EX7A 1C9UA 5M1ZA 4IFNX 2QE8A 1W1XA 4KS2A 4XIKA 2F28A 2FP9A 3SALA 4XMIA 1USXA 1USRA 4MWXA 5F72C 2IAPA 3ALXA 4D52A 3V65B 1B9TA 4K1IA 5D9CA 2QWCA 1NMCA 2HT7A 1EUTA 3KYAA 4K1KA 1INXA 3A9HA 3DR2A 2IAUA 3P5BL 5HUMA 3GVJA 4L7CA 4FPCA 4K1HA 5GX3A 2QWJA 4ASCA 4YY8A 3K38A 4X6KA 3ZGDA 4FP3A 2OJHA 1V3EA 4KS3A 1F8CA 4Q1UA 4XJRA 1INGA 1IVBA 2VSKA 2VSMA 1DILA 4GB1A 1EURA 2HU0A 2DYHA 2XZJA 5FWWA 3S8VA 5FNRA 1CVMA 4GZSA 4GZQA 2SLIA 4FVKA 1MS0A 1EUUA 1QLGA 3AMRA 1L7GA 3A9GA 4HZXA 1F8EA 2GHSA 2W38A 1CRUA 2IASA 2VK6A 3BYCA 4K1JA 2ZB6A 4GNCA 3D12A 2GVXA 4HZWA 3S8ZA 3O9KA 2VK5A 2F24A 3TI6A 1NN2A 2XZIA 1QBIA 1NMBN 3SOVA 1N7DA 4WA4A 1BJIA 4GDIA 1MZ5A 4B7MA 4YZ2A 6NN9A 4X49A 4AGTA 4CSDA 4NC5A 2YDPA 3FW0A 5FNQA 5FNSA 4FQ4A 5GX2A 4FPYA 4H52A 1L7FA 3CKZA 1E8VA 2QWFA 3K37A 1IVCA 4SLIA 1W8NA 4PWZA 3K36A 4HHOA 4GZXA 4HIZA 2SIMA 2YA7A 1S18A 4XMBA 2GVUA 4WA3A 1K32A 5EO8A 2HTWA 1NCBN 3H71A 1SO7A 4IFJA 3TI5A 2AGSA 2C4LA 4GN7A 4XJQA 3INBA 2BZDA 4IQKA 4QNPA 1A4QA 3WW9A 5GX1A 2DG0A 4FPOB 1B9SA 4NCSA 4CPOA 2YA5A 3DASA 1EUSA 2P4OA 1S0IA 2IARA 1CQ1A 4GJTA 4FPHA 1IVDA 5CGJA 4YZ1A 1Z4ZA 4HZYA 2IAXA 3ALWA 4NN9A 3H73A 3I1CA 4B7JA 1N1SA 4MWQA 1A14N 2FHRA 1H6LA 2YA4A 4AGIA 4D52B 1U6DX 3B69A 3TI3A 4MWWA 3O4PA 4WEFA 3S94A 3SLIA 4MWJA 2FP8A 1SLLA 4AH4A 3AMSA 2HTYA 2ISMA 1N1TA 5GX5A 4FZHA 5FNTA 5B2CA 4R40A 2HT8A 2ZB5A 1Z4VA 3TI8A 1NNBA 1IVEA 3CL2A 4O5TA 1RWLA 2VWDA 1S1DA 3II7A 4XYXA 3LI5A 4GEZA 4YW1A 4JF7A 4YW4A 1NCCN 1V0EA 1NNAA 2H2UA 4C1YB 2F25A 2XZKA 4ZLRA 1W8OA 1N6DA 4G3NA 4MJVA 2DSOA 3E5ZA 4GDJA 4FPKA 4HW6A 1W0PA 2F27A 2Z32A 2YA8A 4C1YA 4A0PA 4FPEA 4XJUA 2A75A 4D4UA 3GVKA 2VPJA 1INYA 4YW5A 5JYYA 1F8BA 1W20A 1V04A 3HLHA 1V3BA 2IATA 2W20A
chains in the Genus database with same CATH topology
5FZJA 3ZGDA 4ZGCA 1ZGKA 2XN4A 4N1BA 3ADEA 5FNTA 5FZNA 4IN4A 5CGJA 3WDZA 2Z32A 3WN7A 2DYHA 5FNRA 4XMBA 3VNGA 5FNUA 4L7BA 2WOZA 4IFNX 2FLUX 3II7A 4IFJA 4L7DA 1U6DX 2VPJA 2ZZKA 4L7CA 1X2JA 4ZY3A 3VNHA 2ZW9A 3ZGCA 4IQKA 5FNQA 5FNSA 4IFLX 4CHBA 1X2RA 5F72C 2ZWAA 4CH9A 4ASCA 4YY8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FZJ A;  3ZGD A;  4ZGC A;  1ZGK A;  2XN4 A;  4N1B A;  3ADE A;  5FNT A;  5FZN A;  4IN4 A;  5CGJ A;  3WDZ A;  2Z32 A;  3WN7 A;  2DYH A;  5FNR A;  4XMB A;  3VNG A;  5FNU A;  4L7B A;  2WOZ A;  4IFN X;  2FLU X;  3II7 A;  4IFJ A;  4L7D A;  1U6D X;  2VPJ A;  2ZZK A;  4L7C A;  1X2J A;  4ZY3 A;  3VNH A;  2ZW9 A;  3ZGC A;  4IQK A;  5FNQ A;  5FNS A;  4IFL X;  4CHB A;  1X2R A;  5F72 C;  2ZWA A;  4CH9 A;  4ASC A;  4YY8 A; 
#chains in the Genus database with same CATH topology
 2XN4 A;  4CPL A;  4N1B A;  3HLI A;  1F8D A;  3WDZ A;  4FOQ A;  3V1S A;  4BBW A;  2BER A;  3WWA A;  2IVZ A;  4M4U A;  1XOG A;  2HTQ A;  1V3C A;  2G8S A;  2HU4 A;  2QWA A;  3H72 A;  3LI3 A;  4QN3 A;  4I00 A;  4M3M A;  1MS4 A;  4ZY3 A;  3Q6T A;  4XIL A;  3LI4 A;  3SAN A;  2ZW9 A;  4GN9 A;  4HZZ A;  4XJ9 A;  4HZV A;  3NSS A;  4CPY A;  1NPE A;  2QWK A;  4FPJ A;  1W21 A;  3CYE A;  4MZE A;  2XCY A;  3O9J A;  4M4N A;  4GZO A;  4CPM A;  4YZ4 A;  2VW1 A;  4CPN A;  4D52 C;  4XHB A;  4IMB A;  4X47 A;  1RWI A;  2FPC A;  1INF A;  1N1Y A;  1X2J A;  3NO0 A;  5D9D A;  3S2K A;  1Z4W A;  3Q6P A;  3D11 A;  3PJQ A;  4FP2 A;  4GZP A;  3TI4 A;  1ZGK A;  2W5O A;  4MWY A;  1NSC A;  2IAQ A;  1W0O A;  1MS3 A;  2YA6 A;  1N6F A;  1KIT A;  4O5S A;  2F26 A;  4YW3 A;  3KGG A;  1E8U A;  1MS1 A;  4GNB A;  5NN9 A;  5HUK A;  1Z4Y A;  2F11 A;  3K39 A;  1INV A;  3B7E A;  1ZI0 A;  4IFL X;  3G4E A;  2C4A A;  3GVL A;  1WCS A;  2HTV A;  1OFZ A;  3A71 A;  5EO7 A;  4WEG A;  1MR5 A;  4K3Y A;  4HHQ A;  4FJ6 A;  1IVF A;  1N6E A;  1IVG A;  3IAX A;  4FPG A;  3SOB B;  3V64 C;  4UF7 A;  4QN4 A;  3G4H A;  5HUG A;  5HUN A;  2DG1 A;  1XOE A;  4KS4 A;  5FNU A;  2QWE A;  3TC9 A;  2FLU X;  3HRP A;  4FOY A;  5F9T A;  5D9B A;  1N1V A;  1WCQ A;  1Q7F A;  1V0Z A;  4DGR A;  2HTR A;  5H47 A;  1INH A;  2ZWA A;  1SUU A;  4MWL A;  2GVW A;  4XJ8 A;  3SRE A;  3CL0 A;  1NSB A;  3ADE A;  2F29 A;  2AEP A;  4WA5 A;  4FPL A;  1DIM A;  4XJA A;  2VAQ A;  1POO A;  1A4G A;  4QN7 A;  1IJQ A;  4J9T A;  4QN6 A;  3L6V A;  4XHX A;  3SOQ A;  3ZGC A;  3U0S A;  1C5K A;  4CH9 A;  5GX4 A;  4CPZ A;  2QWH A;  2VK7 A;  1WP5 A;  2VVZ A;  1MZ6 A;  3W09 A;  2SIL A;  4XJZ A;  4D8S A;  1SLI A;  1Z4X A;  5FZN A;  1NSD A;  4FOV A;  4B7Q A;  2FPB A;  4JML A;  4FOW A;  1V3D A;  4YW2 A;  4YZ3 A;  4GZW A;  4MWV A;  2QWB A;  2IAV A;  3VNG A;  1V0F A;  2BAT A;  1MS5 A;  2HQS A;  2WOZ A;  1MS8 A;  2HTU A;  4MX0 A;  3VNH A;  4QN5 A;  2V91 A;  4Q6K A;  4GZT A;  3TIA A;  4CHB A;  2QWG A;  1E1A A;  1NMA N;  1CRZ A;  3A72 A;  4XIO A;  4YZ5 A;  3NN9 A;  2F0Z A;  4ZGC A;  5HX0 A;  2F13 A;  1PJX A;  4IN4 A;  4KS5 A;  4X4A A;  4MC7 A;  1B9V A;  3SRG A;  3JU4 A;  1IUC A;  4UOU A;  1NNC A;  2VW2 A;  2HT5 A;  2BF6 A;  3SIL A;  1SNT A;  2RKC A;  4MWR A;  4B7R A;  4M4V A;  1NCD N;  4L7D A;  5B2D A;  2ZZK A;  4XOG A;  4MJU A;  3K3A A;  2VW0 A;  1MWE A;  2GVV A;  2W5N A;  2QWD A;  4AHA A;  3FVZ A;  3BEQ A;  2JKB A;  2F12 A;  2IAW A;  3TIC A;  2CML A;  1E8T A;  1MS9 A;  2AEQ A;  4MWU A;  2IAO A;  2H2N A;  3T1E A;  4L7B A;  3Q6K A;  2YDT A;  2QWI A;  1S0J A;  2POO A;  4FPF A;  4GN8 A;  4MZA A;  2AH2 A;  4KS1 A;  4GNA A;  1V2I A;  5GTQ A;  2W8B B;  3UC1 A;  1Z50 A;  1X2R A;  2X9M A;  5FZJ A;  4B7N A;  7NN9 A;  1IUB A;  4H53 A;  1VCJ A;  4XE9 A;  4XJW A;  3H6J A;  4IYG A;  3OPZ A;  3TIB A;  3WN7 A;  2W8B A;  1VCU A;  1NCA N;  4DG6 A;  1INW A;  4XMA A;  1L7H A;  2F10 A;  2B8H A;  5EX7 A;  1C9U A;  5M1Z A;  4IFN X;  2QE8 A;  1W1X A;  4KS2 A;  4XIK A;  2F28 A;  2FP9 A;  3SAL A;  4XMI A;  1USX A;  1USR A;  4MWX A;  5F72 C;  2IAP A;  3ALX A;  4D52 A;  3V65 B;  1B9T A;  4K1I A;  5D9C A;  2QWC A;  1NMC A;  2HT7 A;  1EUT A;  3KYA A;  4K1K A;  1INX A;  3A9H A;  3DR2 A;  2IAU A;  3P5B L;  5HUM A;  3GVJ A;  4L7C A;  4FPC A;  4K1H A;  5GX3 A;  2QWJ A;  4ASC A;  4YY8 A;  3K38 A;  4X6K A;  3ZGD A;  4FP3 A;  2OJH A;  1V3E A;  4KS3 A;  1F8C A;  4Q1U A;  4XJR A;  1ING A;  1IVB A;  2VSK A;  2VSM A;  1DIL A;  4GB1 A;  1EUR A;  2HU0 A;  2DYH A;  2XZJ A;  5FWW A;  3S8V A;  5FNR A;  1CVM A;  4GZS A;  4GZQ A;  2SLI A;  4FVK A;  1MS0 A;  1EUU A;  1QLG A;  3AMR A;  1L7G A;  3A9G A;  4HZX A;  1F8E A;  2GHS A;  2W38 A;  1CRU A;  2IAS A;  2VK6 A;  3BYC A;  4K1J A;  2ZB6 A;  4GNC A;  3D12 A;  2GVX A;  4HZW A;  3S8Z A;  3O9K A;  2VK5 A;  2F24 A;  3TI6 A;  1NN2 A;  2XZI A;  1QBI A;  1NMB N;  3SOV A;  1N7D A;  4WA4 A;  1BJI A;  4GDI A;  1MZ5 A;  4B7M A;  4YZ2 A;  6NN9 A;  4X49 A;  4AGT A;  4CSD A;  4NC5 A;  2YDP A;  3FW0 A;  5FNQ A;  5FNS A;  4FQ4 A;  5GX2 A;  4FPY A;  4H52 A;  1L7F A;  3CKZ A;  1E8V A;  2QWF A;  3K37 A;  1IVC A;  4SLI A;  1W8N A;  4PWZ A;  3K36 A;  4HHO A;  4GZX A;  4HIZ A;  2SIM A;  2YA7 A;  1S18 A;  4XMB A;  2GVU A;  4WA3 A;  1K32 A;  5EO8 A;  2HTW A;  1NCB N;  3H71 A;  1SO7 A;  4IFJ A;  3TI5 A;  2AGS A;  2C4L A;  4GN7 A;  4XJQ A;  3INB A;  2BZD A;  4IQK A;  4QNP A;  1A4Q A;  3WW9 A;  5GX1 A;  2DG0 A;  4FPO B;  1B9S A;  4NCS A;  4CPO A;  2YA5 A;  3DAS A;  1EUS A;  2P4O A;  1S0I A;  2IAR A;  1CQ1 A;  4GJT A;  4FPH A;  1IVD A;  5CGJ A;  4YZ1 A;  1Z4Z A;  4HZY A;  2IAX A;  3ALW A;  4NN9 A;  3H73 A;  3I1C A;  4B7J A;  1N1S A;  4MWQ A;  1A14 N;  2FHR A;  1H6L A;  2YA4 A;  4AGI A;  4D52 B;  1U6D X;  3B69 A;  3TI3 A;  4MWW A;  3O4P A;  4WEF A;  3S94 A;  3SLI A;  4MWJ A;  2FP8 A;  1SLL A;  4AH4 A;  3AMS A;  2HTY A;  2ISM A;  1N1T A;  5GX5 A;  4FZH A;  5FNT A;  5B2C A;  4R40 A;  2HT8 A;  2ZB5 A;  1Z4V A;  3TI8 A;  1NNB A;  1IVE A;  3CL2 A;  4O5T A;  1RWL A;  2VWD A;  1S1D A;  3II7 A;  4XYX A;  3LI5 A;  4GEZ A;  4YW1 A;  4JF7 A;  4YW4 A;  1NCC N;  1V0E A;  1NNA A;  2H2U A;  4C1Y B;  2F25 A;  2XZK A;  4ZLR A;  1W8O A;  1N6D A;  4G3N A;  4MJV A;  2DSO A;  3E5Z A;  4GDJ A;  4FPK A;  4HW6 A;  1W0P A;  2F27 A;  2Z32 A;  2YA8 A;  4C1Y A;  4A0P A;  4FPE A;  4XJU A;  2A75 A;  4D4U A;  3GVK A;  2VPJ A;  1INY A;  4YW5 A;  5JYY A;  1F8B A;  1W20 A;  1V04 A;  3HLH A;  1V3B A;  2IAT A;  2W20 A; 
#chains in the Genus database with same CATH homology
 5FZJ A;  3ZGD A;  4ZGC A;  1ZGK A;  2XN4 A;  4N1B A;  3ADE A;  5FNT A;  5FZN A;  4IN4 A;  5CGJ A;  3WDZ A;  2Z32 A;  3WN7 A;  2DYH A;  5FNR A;  4XMB A;  3VNG A;  5FNU A;  4L7B A;  2WOZ A;  4IFN X;  2FLU X;  3II7 A;  4IFJ A;  4L7D A;  1U6D X;  2VPJ A;  2ZZK A;  4L7C A;  1X2J A;  4ZY3 A;  3VNH A;  2ZW9 A;  3ZGC A;  4IQK A;  5FNQ A;  5FNS A;  4IFL X;  4CHB A;  1X2R A;  5F72 C;  2ZWA A;  4CH9 A;  4ASC A;  4YY8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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