1X2RA

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of keap1 on nrf2
Total Genus 67

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
source organism Mus musculus
publication title Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
pubmed doi rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 67
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2005-04-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 1x2rA00
4CH9A 3II7A 5FZNA 1ZGKA 3WDZA 3WN7A 5FNTA 1X2JA 1X2RA 4IN4A 4IFNX 2Z32A 4L7BA 4L7CA 4CHBA 5FNQA 3ZGCA 2FLUX 4N1BA 3ZGDA 2VPJA 2ZZKA 3VNHA 4ZGCA 2DYHA 4XMBA 2XN4A 5FZJA 4IFJA 4YY8A 2WOZA 4L7DA 2ZWAA 3VNGA 3ADEA 5F72C 5FNRA 5FNUA 5CGJA 4IFLX 4ASCA 4ZY3A 1U6DX 5FNSA 4IQKA 2ZW9A
chains in the Genus database with same CATH superfamily
1IJQA 2ZB5A 3O4PA 3O9JA 5H47A 2IAOA 3E5ZA 1Q7FA 3HLHA 1S1DA 1EUUA 2AEPA 2W8BA 2XZKA 4CHBA 4QN4A 2YA8A 2HT8A 4HW6A 1SO7A 2FPCA 1NSDA 3VNGA 1NNCA 1N6EA 3S94A 1NCBN 1Z4WA 4KS1A 5D9CA 1CRUA 1DIMA 2B8HA 1Z50A 2AEQA 4FP2A 6NN9A 3S8VA 3INBA 4MZEA 1X2RA 4M4NA 2SILA 4XHXA 3H73A 4XMAA 2F29A 4WEGA 2VSMA 3SREA 4HZWA 3HRPA 4XMBA 2FPBA 4MWUA 4HIZA 2IAVA 3HLIA 3A71A 2VK5A 3SRGA 5CGJA 4IFLX 4I00A 1W1XA 4A0PA 4FPLA 5GX4A 1EUTA 4Q1UA 1E8UA 3GVJA 4ZLRA 2SLIA 2W8BB 1W21A 4DGRA 3S2KA 2IATA 4MZAA 1NMCA 4K1IA 2VPJA 1VCJA 1MS4A 4FPHA 3Q6TA 4FZHA 2W38A 5B2CA 1IVDA 2QWEA 5F72C 4UF7A 2G8SA 1L7GA 2F24A 4XE9A 1U6DX 4K1JA 4MWXA 2F25A 4MJVA 1Z4ZA 4MWLA 2HTUA 4YW5A 2F26A 3TI8A 2QWGA 3V1SA 3FVZA 2VW2A 4IMBA 4B7NA 5M1ZA 4ZGCA 2XCYA 3SLIA 4Q6KA 3K36A 5FZJA 1EUSA 4MWVA 2GHSA 4QNPA 3TI6A 3H72A 4B7RA 3B69A 4ASCA 4XJ8A 1F8EA 3L6VA 4WA5A 1INWA 3ALWA 1NPEA 4GZTA 3H6JA 1IVGA 4L7BA 1NSCA 1V3DA 4FOWA 4QN6A 4QN5A 3SALA 4BBWA 2HTQA 5HUKA 3O9KA 4HZXA 4KS5A 4MWWA 4FOQA 4IFJA 2ZWAA 2IAXA 4FPJA 4MX0A 4AGTA 4KS3A 4HZZA 2QWJA 3TICA 5JYYA 1V0FA 3IAXA 4IQKA 1WP5A 2HTRA 3H71A 1XOEA 1E1AA 4K1KA 1QBIA 4CPNA 2HTWA 2H2UA 4IN4A 1NNBA 2F0ZA 2VSKA 4GEZA 3AMSA 1C9UA 1F8DA 2F28A 4WA3A 3SANA 1MZ5A 4YZ2A 3ALXA 2IAQA 2W20A 2YA6A 3FW0A 2XZIA 4GN9A 2VW1A 3LI3A 5FWWA 1W0OA 1V3CA 4JMLA 4GDJA 4CPOA 2W5NA 1IVEA 5EX7A 4AH4A 4JF7A 3TI4A 2F10A 1SUUA 1INVA 1USRA 3GVLA 3WDZA 4XYXA 4MWRA 3WN7A 4GZOA 1INXA 3ZGCA 1A14N 1DILA 3VNHA 3BYCA 1F8CA 4CPYA 3V64C 2VW0A 4H52A 2HT7A 1SLIA 4O5SA 3CL0A 2DSOA 4R40A 5GX2A 1IUBA 4K3YA 2BATA 2IVZA 4XJAA 7NN9A 1NCDN 2H2NA 3NSSA 2ZW9A 2QWAA 1INHA 1V0ZA 3WW9A 2DG1A 4MWQA 1INYA 1POOA 4PWZA 4CPMA 4FPYA 2P4OA 1NSBA 1K32A 1SLLA 4GZQA 4L7DA 3UC1A 2BF6A 2VVZA 4CPZA 2DG0A 5FNRA 4O5TA 1MWEA 2YA5A 4ZY3A 5GX1A 2BZDA 1Z4YA 3SOBB 3CYEA 1VCUA 2IAWA 1F8BA 1ZGKA 1QLGA 1NNAA 3K3AA 3LI4A 1L7HA 5NN9A 4KS4A 2IAPA 4FJ6A 2QWFA 5GX3A 3TIAA 4B7MA 1L7FA 2QWKA 3WWAA 4XOGA 3AMRA 4XILA 4YW4A 3GVKA 2VAQA 4GN7A 3BEQA 4FVKA 2F27A 1XOGA 1NCAN 4GNCA 2XZJA 2ISMA 1INFA 4D52A 4NC5A 1MS0A 4FPFA 1NCCN 3K39A 4M3MA 1S0IA 5FZNA 2F11A 2FHRA 2C4LA 1NMBN 4H53A 1NMAN 4YW1A 1WCQA 2FLUX 4N1BA 3ZGDA 1OFZA 1V04A 4X6KA 4GB1A 4YW3A 5HUNA 4YY8A 3DASA 2QWCA 4HZYA 3A72A 3P5BL 3A9HA 2YA7A 1N6FA 3G4HA 1IVBA 2QE8A 5FNSA 4FOVA 2HT5A 3K38A 1Z4XA 3OPZA 3Q6PA 2A75A 4IFNX 3D11A 1A4GA 1PJXA 1H6LA 2V91A 2ZZKA 3NO0A 4FPOB 2HU4A 4MWJA 4YZ3A 1N7DA 3D12A 2HTYA 4CSDA 4D52C 2QWDA 4GZPA 4UOUA 3V65B 2FP8A 2POOA 4FPEA 4D52B 5HUGA 1V0EA 4G3NA 4GJTA 2AH2A 4XJ9A 2X9MA 3SOQA 4AHAA 3A9GA 4MC7A 2IARA 4QN7A 1B9SA 4M4UA 1N1VA 2Z32A 3KGGA 3CKZA 4GZSA 1S0JA 4HHOA 3TC9A 2W5OA 2QWHA 2YDTA 1CQ1A 1MS9A 4HHQA 4XJZA 3S8ZA 4AGIA 1IUCA 4WEFA 1INGA 5HUMA 1NN2A 3PJQA 4XJQA 4B7JA 4FQ4A 4X49A 1Z4VA 1IVFA 2VK7A 1IVCA 3LI5A 4MWYA 4C1YA 2FP9A 1N1SA 3I1CA 5EO7A 3W09A 4M4VA 3U0SA 1EURA 4FP3A 5F9TA 2GVVA 2VWDA 5HX0A 2HU0A 1V2IA 4YW2A 5FNUA 4XHBA 4YZ4A 1N1TA 2GVWA 4NCSA 2QWIA 2YDPA 3SILA 3TI3A 4FOYA 4QN3A 1MS3A 1MS8A 5EO8A 5FNTA 3Q6KA 5GTQA 4FPKA 1MZ6A 4B7QA 4GDIA 4X47A 2AGSA 3DR2A 2RKCA 2BERA 1USXA 2DYHA 1V3BA 4XJRA 4D4UA 4NN9A 2IASA 1E8TA 4XIOA 3K37A 3KYAA 3B7EA 4FPGA 4YZ1A 4MJUA 3II7A 2F13A 1CRZA 4GZWA 2CMLA 2SIMA 2HTVA 3TIBA 4K1HA 4GNAA 1X2JA 4C1YB 3NN9A 2C4AA 1N1YA 4IYGA 4HZVA 4GZXA 5D9DA 4CPLA 5GX5A 1MS1A 1W20A 2QWBA 1C5KA 2XN4A 1B9VA 2WOZA 3ADEA 1RWIA 1RWLA 4GNBA 1W8OA 2YA4A 3T1EA 4D8SA 1S18A 1N6DA 2F12A 3JU4A 4WA4A 4KS2A 2GVXA 3CL2A 4CH9A 2OJHA 2HQSA 2VK6A 1BJIA 1KITA 4SLIA 5B2DA 4FPCA 1V3EA 4XJUA 4J9TA 4XJWA 1MR5A 1A4QA 4L7CA 1W8NA 5FNQA 1W0PA 2JKBA 1CVMA 3SOVA 5D9BA 2GVUA 2IAUA 4YZ5A 3TI5A 4GN8A 4XMIA 4DG6A 3G4EA 1ZI0A 1B9TA 1MS5A 4XIKA 1SNTA 1WCSA 1E8VA 2ZB6A 4X4AA
chains in the Genus database with same CATH topology
4CH9A 3II7A 5FZNA 1ZGKA 3WDZA 3WN7A 5FNTA 1X2JA 1X2RA 4IN4A 4IFNX 2Z32A 4L7BA 4L7CA 4CHBA 5FNQA 3ZGCA 2FLUX 4N1BA 3ZGDA 2VPJA 2ZZKA 3VNHA 4ZGCA 2DYHA 4XMBA 2XN4A 5FZJA 4IFJA 4YY8A 2WOZA 4L7DA 2ZWAA 3VNGA 3ADEA 5F72C 5FNRA 5FNUA 5CGJA 4IFLX 4ASCA 4ZY3A 1U6DX 5FNSA 4IQKA 2ZW9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CH9 A;  3II7 A;  5FZN A;  1ZGK A;  3WDZ A;  3WN7 A;  5FNT A;  1X2J A;  1X2R A;  4IN4 A;  4IFN X;  2Z32 A;  4L7B A;  4L7C A;  4CHB A;  5FNQ A;  3ZGC A;  2FLU X;  4N1B A;  3ZGD A;  2VPJ A;  2ZZK A;  3VNH A;  4ZGC A;  2DYH A;  4XMB A;  2XN4 A;  5FZJ A;  4IFJ A;  4YY8 A;  2WOZ A;  4L7D A;  2ZWA A;  3VNG A;  3ADE A;  5F72 C;  5FNR A;  5FNU A;  5CGJ A;  4IFL X;  4ASC A;  4ZY3 A;  1U6D X;  5FNS A;  4IQK A;  2ZW9 A; 
#chains in the Genus database with same CATH topology
 1IJQ A;  2ZB5 A;  3O4P A;  3O9J A;  5H47 A;  2IAO A;  3E5Z A;  1Q7F A;  3HLH A;  1S1D A;  1EUU A;  2AEP A;  2W8B A;  2XZK A;  4CHB A;  4QN4 A;  2YA8 A;  2HT8 A;  4HW6 A;  1SO7 A;  2FPC A;  1NSD A;  3VNG A;  1NNC A;  1N6E A;  3S94 A;  1NCB N;  1Z4W A;  4KS1 A;  5D9C A;  1CRU A;  1DIM A;  2B8H A;  1Z50 A;  2AEQ A;  4FP2 A;  6NN9 A;  3S8V A;  3INB A;  4MZE A;  1X2R A;  4M4N A;  2SIL A;  4XHX A;  3H73 A;  4XMA A;  2F29 A;  4WEG A;  2VSM A;  3SRE A;  4HZW A;  3HRP A;  4XMB A;  2FPB A;  4MWU A;  4HIZ A;  2IAV A;  3HLI A;  3A71 A;  2VK5 A;  3SRG A;  5CGJ A;  4IFL X;  4I00 A;  1W1X A;  4A0P A;  4FPL A;  5GX4 A;  1EUT A;  4Q1U A;  1E8U A;  3GVJ A;  4ZLR A;  2SLI A;  2W8B B;  1W21 A;  4DGR A;  3S2K A;  2IAT A;  4MZA A;  1NMC A;  4K1I A;  2VPJ A;  1VCJ A;  1MS4 A;  4FPH A;  3Q6T A;  4FZH A;  2W38 A;  5B2C A;  1IVD A;  2QWE A;  5F72 C;  4UF7 A;  2G8S A;  1L7G A;  2F24 A;  4XE9 A;  1U6D X;  4K1J A;  4MWX A;  2F25 A;  4MJV A;  1Z4Z A;  4MWL A;  2HTU A;  4YW5 A;  2F26 A;  3TI8 A;  2QWG A;  3V1S A;  3FVZ A;  2VW2 A;  4IMB A;  4B7N A;  5M1Z A;  4ZGC A;  2XCY A;  3SLI A;  4Q6K A;  3K36 A;  5FZJ A;  1EUS A;  4MWV A;  2GHS A;  4QNP A;  3TI6 A;  3H72 A;  4B7R A;  3B69 A;  4ASC A;  4XJ8 A;  1F8E A;  3L6V A;  4WA5 A;  1INW A;  3ALW A;  1NPE A;  4GZT A;  3H6J A;  1IVG A;  4L7B A;  1NSC A;  1V3D A;  4FOW A;  4QN6 A;  4QN5 A;  3SAL A;  4BBW A;  2HTQ A;  5HUK A;  3O9K A;  4HZX A;  4KS5 A;  4MWW A;  4FOQ A;  4IFJ A;  2ZWA A;  2IAX A;  4FPJ A;  4MX0 A;  4AGT A;  4KS3 A;  4HZZ A;  2QWJ A;  3TIC A;  5JYY A;  1V0F A;  3IAX A;  4IQK A;  1WP5 A;  2HTR A;  3H71 A;  1XOE A;  1E1A A;  4K1K A;  1QBI A;  4CPN A;  2HTW A;  2H2U A;  4IN4 A;  1NNB A;  2F0Z A;  2VSK A;  4GEZ A;  3AMS A;  1C9U A;  1F8D A;  2F28 A;  4WA3 A;  3SAN A;  1MZ5 A;  4YZ2 A;  3ALX A;  2IAQ A;  2W20 A;  2YA6 A;  3FW0 A;  2XZI A;  4GN9 A;  2VW1 A;  3LI3 A;  5FWW A;  1W0O A;  1V3C A;  4JML A;  4GDJ A;  4CPO A;  2W5N A;  1IVE A;  5EX7 A;  4AH4 A;  4JF7 A;  3TI4 A;  2F10 A;  1SUU A;  1INV A;  1USR A;  3GVL A;  3WDZ A;  4XYX A;  4MWR A;  3WN7 A;  4GZO A;  1INX A;  3ZGC A;  1A14 N;  1DIL A;  3VNH A;  3BYC A;  1F8C A;  4CPY A;  3V64 C;  2VW0 A;  4H52 A;  2HT7 A;  1SLI A;  4O5S A;  3CL0 A;  2DSO A;  4R40 A;  5GX2 A;  1IUB A;  4K3Y A;  2BAT A;  2IVZ A;  4XJA A;  7NN9 A;  1NCD N;  2H2N A;  3NSS A;  2ZW9 A;  2QWA A;  1INH A;  1V0Z A;  3WW9 A;  2DG1 A;  4MWQ A;  1INY A;  1POO A;  4PWZ A;  4CPM A;  4FPY A;  2P4O A;  1NSB A;  1K32 A;  1SLL A;  4GZQ A;  4L7D A;  3UC1 A;  2BF6 A;  2VVZ A;  4CPZ A;  2DG0 A;  5FNR A;  4O5T A;  1MWE A;  2YA5 A;  4ZY3 A;  5GX1 A;  2BZD A;  1Z4Y A;  3SOB B;  3CYE A;  1VCU A;  2IAW A;  1F8B A;  1ZGK A;  1QLG A;  1NNA A;  3K3A A;  3LI4 A;  1L7H A;  5NN9 A;  4KS4 A;  2IAP A;  4FJ6 A;  2QWF A;  5GX3 A;  3TIA A;  4B7M A;  1L7F A;  2QWK A;  3WWA A;  4XOG A;  3AMR A;  4XIL A;  4YW4 A;  3GVK A;  2VAQ A;  4GN7 A;  3BEQ A;  4FVK A;  2F27 A;  1XOG A;  1NCA N;  4GNC A;  2XZJ A;  2ISM A;  1INF A;  4D52 A;  4NC5 A;  1MS0 A;  4FPF A;  1NCC N;  3K39 A;  4M3M A;  1S0I A;  5FZN A;  2F11 A;  2FHR A;  2C4L A;  1NMB N;  4H53 A;  1NMA N;  4YW1 A;  1WCQ A;  2FLU X;  4N1B A;  3ZGD A;  1OFZ A;  1V04 A;  4X6K A;  4GB1 A;  4YW3 A;  5HUN A;  4YY8 A;  3DAS A;  2QWC A;  4HZY A;  3A72 A;  3P5B L;  3A9H A;  2YA7 A;  1N6F A;  3G4H A;  1IVB A;  2QE8 A;  5FNS A;  4FOV A;  2HT5 A;  3K38 A;  1Z4X A;  3OPZ A;  3Q6P A;  2A75 A;  4IFN X;  3D11 A;  1A4G A;  1PJX A;  1H6L A;  2V91 A;  2ZZK A;  3NO0 A;  4FPO B;  2HU4 A;  4MWJ A;  4YZ3 A;  1N7D A;  3D12 A;  2HTY A;  4CSD A;  4D52 C;  2QWD A;  4GZP A;  4UOU A;  3V65 B;  2FP8 A;  2POO A;  4FPE A;  4D52 B;  5HUG A;  1V0E A;  4G3N A;  4GJT A;  2AH2 A;  4XJ9 A;  2X9M A;  3SOQ A;  4AHA A;  3A9G A;  4MC7 A;  2IAR A;  4QN7 A;  1B9S A;  4M4U A;  1N1V A;  2Z32 A;  3KGG A;  3CKZ A;  4GZS A;  1S0J A;  4HHO A;  3TC9 A;  2W5O A;  2QWH A;  2YDT A;  1CQ1 A;  1MS9 A;  4HHQ A;  4XJZ A;  3S8Z A;  4AGI A;  1IUC A;  4WEF A;  1ING A;  5HUM A;  1NN2 A;  3PJQ A;  4XJQ A;  4B7J A;  4FQ4 A;  4X49 A;  1Z4V A;  1IVF A;  2VK7 A;  1IVC A;  3LI5 A;  4MWY A;  4C1Y A;  2FP9 A;  1N1S A;  3I1C A;  5EO7 A;  3W09 A;  4M4V A;  3U0S A;  1EUR A;  4FP3 A;  5F9T A;  2GVV A;  2VWD A;  5HX0 A;  2HU0 A;  1V2I A;  4YW2 A;  5FNU A;  4XHB A;  4YZ4 A;  1N1T A;  2GVW A;  4NCS A;  2QWI A;  2YDP A;  3SIL A;  3TI3 A;  4FOY A;  4QN3 A;  1MS3 A;  1MS8 A;  5EO8 A;  5FNT A;  3Q6K A;  5GTQ A;  4FPK A;  1MZ6 A;  4B7Q A;  4GDI A;  4X47 A;  2AGS A;  3DR2 A;  2RKC A;  2BER A;  1USX A;  2DYH A;  1V3B A;  4XJR A;  4D4U A;  4NN9 A;  2IAS A;  1E8T A;  4XIO A;  3K37 A;  3KYA A;  3B7E A;  4FPG A;  4YZ1 A;  4MJU A;  3II7 A;  2F13 A;  1CRZ A;  4GZW A;  2CML A;  2SIM A;  2HTV A;  3TIB A;  4K1H A;  4GNA A;  1X2J A;  4C1Y B;  3NN9 A;  2C4A A;  1N1Y A;  4IYG A;  4HZV A;  4GZX A;  5D9D A;  4CPL A;  5GX5 A;  1MS1 A;  1W20 A;  2QWB A;  1C5K A;  2XN4 A;  1B9V A;  2WOZ A;  3ADE A;  1RWI A;  1RWL A;  4GNB A;  1W8O A;  2YA4 A;  3T1E A;  4D8S A;  1S18 A;  1N6D A;  2F12 A;  3JU4 A;  4WA4 A;  4KS2 A;  2GVX A;  3CL2 A;  4CH9 A;  2OJH A;  2HQS A;  2VK6 A;  1BJI A;  1KIT A;  4SLI A;  5B2D A;  4FPC A;  1V3E A;  4XJU A;  4J9T A;  4XJW A;  1MR5 A;  1A4Q A;  4L7C A;  1W8N A;  5FNQ A;  1W0P A;  2JKB A;  1CVM A;  3SOV A;  5D9B A;  2GVU A;  2IAU A;  4YZ5 A;  3TI5 A;  4GN8 A;  4XMI A;  4DG6 A;  3G4E A;  1ZI0 A;  1B9T A;  1MS5 A;  4XIK A;  1SNT A;  1WCS A;  1E8V A;  2ZB6 A;  4X4A A; 
#chains in the Genus database with same CATH homology
 4CH9 A;  3II7 A;  5FZN A;  1ZGK A;  3WDZ A;  3WN7 A;  5FNT A;  1X2J A;  1X2R A;  4IN4 A;  4IFN X;  2Z32 A;  4L7B A;  4L7C A;  4CHB A;  5FNQ A;  3ZGC A;  2FLU X;  4N1B A;  3ZGD A;  2VPJ A;  2ZZK A;  3VNH A;  4ZGC A;  2DYH A;  4XMB A;  2XN4 A;  5FZJ A;  4IFJ A;  4YY8 A;  2WOZ A;  4L7D A;  2ZWA A;  3VNG A;  3ADE A;  5F72 C;  5FNR A;  5FNU A;  5CGJ A;  4IFL X;  4ASC A;  4ZY3 A;  1U6D X;  5FNS A;  4IQK A;  2ZW9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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