1X2RA

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of keap1 on nrf2
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
pubmed doi rcsb
molecule tags Transcription
source organism Mus musculus
molecule keywords Kelch-like ECH-associated protein 1
total genus 67
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2005-04-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 1x2rA00
4IFJA 5FNRA 2DYHA 3ADEA 4L7DA 4CHBA 4IN4A 5FNSA 5FNUA 4IQKA 3ZGDA 1U6DX 2Z32A 5CGJA 1ZGKA 2XN4A 2ZZKA 4CH9A 5FNQA 3VNHA 3II7A 3WN7A 4L7CA 2FLUX 2ZWAA 4ZY3A 2ZW9A 4IFLX 4IFNX 4ASCA 3VNGA 4ZGCA 5F72C 3WDZA 1X2JA 1X2RA 5FZNA 3ZGCA 4YY8A 5FNTA 5FZJA 2WOZA 4N1BA 4XMBA 2VPJA 4L7BA
chains in the Genus database with same CATH superfamily
1N6DA 4FJ6A 4WA4A 4GDIA 4KS5A 6NN9A 5B2DA 1ZI0A 1A4GA 4KS3A 4QN7A 1IVBA 4CPMA 3BYCA 3V65B 1NMBN 4XJRA 4AH4A 2QE8A 2ZZKA 5EO7A 2V91A 3II7A 4KS2A 1N1YA 3WN7A 4MZAA 4XMIA 3TC9A 1F8DA 1L7FA 4YZ5A 4GNCA 2FLUX 3ALWA 1POOA 2F13A 4GZOA 4MWWA 4AGTA 3A9GA 2YA8A 1X2JA 1N7DA 4XIKA 3KYAA 4M4UA 4AGIA 2GVXA 2BZDA 3T1EA 4YZ4A 4JF7A 1W1XA 4GN9A 4AHAA 2ZB6A 2IAVA 2F10A 5HUMA 2Z32A 2SLIA 4YW3A 5HUNA 2QWHA 1MS3A 1OFZA 1EUUA 3S8VA 4FPJA 1K32A 1INWA 5GX3A 3B7EA 4MWYA 2W5NA 4C1YB 4NCSA 4WEFA 2F29A 4QN3A 3H71A 2YDTA 4N1BA 2YDPA 4CPLA 4D4UA 4IFJA 3CKZA 1C9UA 3JU4A 4YW5A 1L7HA 1MZ6A 2H2NA 5FNSA 2DSOA 3ZGDA 3CYEA 1IUCA 1S18A 4UOUA 4O5TA 2HTRA 4ZLRA 2W8BB 2VK7A 4K3YA 3I1CA 4M4NA 3TIBA 1B9TA 1VCUA 3OPZA 1Z4WA 2IAOA 4MWXA 3GVLA 1INGA 5FWWA 3FW0A 2F25A 2VK6A 2AGSA 2QWKA 3DASA 4R40A 4H53A 1Z4YA 2HTYA 1INYA 1W0OA 4FPLA 4WA5A 3SOBB 3WDZA 4YY8A 1SO7A 1CVMA 2GVWA 2HT8A 3WWAA 1Z50A 4A0PA 1SLIA 4FQ4A 2FP8A 3LI3A 4K1KA 4YW2A 1USRA 4XJWA 4GEZA 4B7QA 1V04A 2FPBA 2FP9A 4WA3A 4CPYA 5GX1A 3AMRA 1N1TA 5HUKA 2FHRA 1A4QA 1H6LA 2DG1A 2W5OA 5B2CA 4XJ8A 3O4PA 4GZQA 2QWBA 2ZW9A 5F72C 1V3CA 1NCCN 2P4OA 3TI8A 3TIAA 4XJ9A 3SLIA 2XZIA 1MR5A 4FVKA 4FPOB 4MWJA 4KS4A 4QN4A 4MX0A 1INXA 5H47A 2IAUA 4FZHA 4IMBA 2XCYA 1W0PA 1E8VA 1F8CA 3VNHA 3O9KA 3G4EA 1NNCA 2SIMA 2DG0A 1DIMA 4CPOA 1IVGA 2F0ZA 4JMLA 2AEPA 2YA5A 3ALXA 1WP5A 3SREA 3UC1A 5D9BA 3AMSA 3KGGA 1IUBA 3SALA 1BJIA 3GVJA 5FNTA 3U0SA 4MWLA 3H72A 4K1HA 4GZTA 4Q6KA 4L7BA 2VW1A 3NN9A 4K1JA 5FNUA 2IVZA 4CPZA 1U6DX 1CRZA 1L7GA 1Q7FA 4QNPA 4XOGA 3NSSA 1F8EA 3V1SA 3SANA 1Z4XA 5FNQA 4HW6A 4L7CA 2HTUA 2JKBA 1E1AA 4XJZA 1NSBA 4ASCA 4NC5A 4DG6A 2FPCA 3GVKA 3SOQA 1NMAN 3TI4A 2VSMA 2WOZA 3K36A 1QBIA 3TICA 5GX5A 4FOYA 4D52C 4GN7A 1SLLA 1NCDN 1INHA 1ZGKA 2POOA 2F11A 1INVA 1V2IA 2X9MA 4GJTA 1EUTA 2XZJA 4G3NA 1W8OA 3O9JA 1Z4VA 3Q6KA 4XJUA 4FPEA 1SUUA 4B7RA 4D8SA 4J9TA 4FPKA 1XOEA 2VSKA 4GZXA 4XMAA 2ISMA 1MWEA 3TI3A 4X49A 2VW0A 4WEGA 3SILA 2XN4A 1EURA 2VAQA 4B7MA 4KS1A 2BF6A 1MS4A 4GNBA 1V3BA 3E5ZA 2VK5A 2QWDA 3Q6PA 2IAXA 3BEQA 5D9DA 3INBA 2F26A 2HQSA 1W8NA 5GX4A 4MJUA 4HHOA 3K37A 4K1IA 4IN4A 2YA4A 5GX2A 3SRGA 2A75A 1KITA 3B69A 4XHBA 5EO8A 2IARA 4GN8A 4HZXA 4BBWA 1IVCA 1MZ5A 4HZYA 3VNGA 2VVZA 5F9TA 3ZGCA 4O5SA 1MS8A 2HTVA 2CMLA 5D9CA 2VPJA 2GVUA 3HRPA 3IAXA 4L7DA 4CHBA 4HZZA 2F27A 4X47A 1NCAN 2HT5A 2YA7A 5CGJA 1NNAA 4NN9A 2SILA 1CRUA 5JYYA 3H73A 3Q6TA 1IVEA 2F24A 3D11A 4FOWA 3P5BL 2IATA 2QWGA 4IFNX 1CQ1A 2XZKA 2QWCA 1X2RA 4FPFA 2QWIA 3TI6A 4UF7A 4D52A 2QWFA 2AH2A 4YZ3A 4DGRA 3CL0A 3HLHA 1B9VA 4B7JA 2DYHA 1V0EA 1NN2A 4IQKA 4H52A 4IYGA 2YA6A 5HUGA 2C4AA 4FPHA 4M3MA 1SNTA 1F8BA 4QN6A 2F28A 4HZVA 2GVVA 1VCJA 3K38A 4FPYA 3V64C 3S2KA 1E8TA 3NO0A 4M4VA 4X6KA 4GZPA 2HT7A 3A9HA 2GHSA 4I00A 1C5KA 4MJVA 4XYXA 3PJQA 1NCBN 4X4AA 4GDJA 4MC7A 4MWRA 4XJAA 2F12A 3WW9A 1S0IA 3LI5A 3FVZA 4FOVA 2QWAA 1RWLA 4MWQA 1N1SA 4Q1UA 1N1VA 2W20A 4GB1A 1MS0A 5M1ZA 1QLGA 1MS1A 1IVFA 1RWIA 2QWEA 5FNRA 1A14N 3ADEA 2IASA 4GZSA 4XIOA 1USXA 4GNAA 1WCQA 2H2UA 4YZ1A 4XE9A 1V3EA 1N6FA 1E8UA 4XHXA 3LI4A 4FP3A 1EUSA 3TI5A 4ZGCA 3S94A 1NSDA 2IAPA 2G8SA 5GTQA 3A72A 5FZJA 3H6JA 4SLIA 4XMBA 2B8HA 4YW4A 7NN9A 4YW1A 3K3AA 4FP2A 1XOGA 2HTWA 5HX0A 4C1YA 1Z4ZA 4CH9A 1MS5A 4MZEA 2RKCA 3G4HA 2ZWAA 2W38A 2OJHA 3D12A 3CL2A 4XJQA 1IJQA 1INFA 4QN5A 1NMCA 1IVDA 2W8BA 3L6VA 1V3DA 4B7NA 4HZWA 4MWUA 3SOVA 2IAQA 1PJXA 1NNBA 2VWDA 2HU4A 3A71A 4CPNA 1MS9A 4D52B 4HIZA 3DR2A 4FPCA 5EX7A 4PWZA 2HTQA 4CSDA 2BATA 2BERA 4GZWA 3K39A 4IFLX 2VW2A 3S8ZA 2C4LA 1S0JA 1N6EA 2AEQA 1S1DA 2QWJA 3W09A 1W20A 2IAWA 4HHQA 5NN9A 1NPEA 3HLIA 1NSCA 4XILA 4MWVA 1V0ZA 1V0FA 1DILA 4FOQA 1W21A 4FPGA 2ZB5A 4ZY3A 1WCSA 1B9SA 2HU0A 5FZNA 4YZ2A
chains in the Genus database with same CATH topology
4IFJA 5FNRA 2DYHA 3ADEA 4L7DA 4CHBA 4IN4A 5FNSA 5FNUA 4IQKA 3ZGDA 1U6DX 2Z32A 5CGJA 1ZGKA 2XN4A 2ZZKA 4CH9A 5FNQA 3VNHA 3II7A 3WN7A 4L7CA 2FLUX 2ZWAA 4ZY3A 2ZW9A 4IFLX 4IFNX 4ASCA 3VNGA 4ZGCA 5F72C 3WDZA 1X2JA 1X2RA 5FZNA 3ZGCA 4YY8A 5FNTA 5FZJA 2WOZA 4N1BA 4XMBA 2VPJA 4L7BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IFJ A;  5FNR A;  2DYH A;  3ADE A;  4L7D A;  4CHB A;  4IN4 A;  5FNS A;  5FNU A;  4IQK A;  3ZGD A;  1U6D X;  2Z32 A;  5CGJ A;  1ZGK A;  2XN4 A;  2ZZK A;  4CH9 A;  5FNQ A;  3VNH A;  3II7 A;  3WN7 A;  4L7C A;  2FLU X;  2ZWA A;  4ZY3 A;  2ZW9 A;  4IFL X;  4IFN X;  4ASC A;  3VNG A;  4ZGC A;  5F72 C;  3WDZ A;  1X2J A;  1X2R A;  5FZN A;  3ZGC A;  4YY8 A;  5FNT A;  5FZJ A;  2WOZ A;  4N1B A;  4XMB A;  2VPJ A;  4L7B A; 
#chains in the Genus database with same CATH topology
 1N6D A;  4FJ6 A;  4WA4 A;  4GDI A;  4KS5 A;  6NN9 A;  5B2D A;  1ZI0 A;  1A4G A;  4KS3 A;  4QN7 A;  1IVB A;  4CPM A;  3BYC A;  3V65 B;  1NMB N;  4XJR A;  4AH4 A;  2QE8 A;  2ZZK A;  5EO7 A;  2V91 A;  3II7 A;  4KS2 A;  1N1Y A;  3WN7 A;  4MZA A;  4XMI A;  3TC9 A;  1F8D A;  1L7F A;  4YZ5 A;  4GNC A;  2FLU X;  3ALW A;  1POO A;  2F13 A;  4GZO A;  4MWW A;  4AGT A;  3A9G A;  2YA8 A;  1X2J A;  1N7D A;  4XIK A;  3KYA A;  4M4U A;  4AGI A;  2GVX A;  2BZD A;  3T1E A;  4YZ4 A;  4JF7 A;  1W1X A;  4GN9 A;  4AHA A;  2ZB6 A;  2IAV A;  2F10 A;  5HUM A;  2Z32 A;  2SLI A;  4YW3 A;  5HUN A;  2QWH A;  1MS3 A;  1OFZ A;  1EUU A;  3S8V A;  4FPJ A;  1K32 A;  1INW A;  5GX3 A;  3B7E A;  4MWY A;  2W5N A;  4C1Y B;  4NCS A;  4WEF A;  2F29 A;  4QN3 A;  3H71 A;  2YDT A;  4N1B A;  2YDP A;  4CPL A;  4D4U A;  4IFJ A;  3CKZ A;  1C9U A;  3JU4 A;  4YW5 A;  1L7H A;  1MZ6 A;  2H2N A;  5FNS A;  2DSO A;  3ZGD A;  3CYE A;  1IUC A;  1S18 A;  4UOU A;  4O5T A;  2HTR A;  4ZLR A;  2W8B B;  2VK7 A;  4K3Y A;  3I1C A;  4M4N A;  3TIB A;  1B9T A;  1VCU A;  3OPZ A;  1Z4W A;  2IAO A;  4MWX A;  3GVL A;  1ING A;  5FWW A;  3FW0 A;  2F25 A;  2VK6 A;  2AGS A;  2QWK A;  3DAS A;  4R40 A;  4H53 A;  1Z4Y A;  2HTY A;  1INY A;  1W0O A;  4FPL A;  4WA5 A;  3SOB B;  3WDZ A;  4YY8 A;  1SO7 A;  1CVM A;  2GVW A;  2HT8 A;  3WWA A;  1Z50 A;  4A0P A;  1SLI A;  4FQ4 A;  2FP8 A;  3LI3 A;  4K1K A;  4YW2 A;  1USR A;  4XJW A;  4GEZ A;  4B7Q A;  1V04 A;  2FPB A;  2FP9 A;  4WA3 A;  4CPY A;  5GX1 A;  3AMR A;  1N1T A;  5HUK A;  2FHR A;  1A4Q A;  1H6L A;  2DG1 A;  2W5O A;  5B2C A;  4XJ8 A;  3O4P A;  4GZQ A;  2QWB A;  2ZW9 A;  5F72 C;  1V3C A;  1NCC N;  2P4O A;  3TI8 A;  3TIA A;  4XJ9 A;  3SLI A;  2XZI A;  1MR5 A;  4FVK A;  4FPO B;  4MWJ A;  4KS4 A;  4QN4 A;  4MX0 A;  1INX A;  5H47 A;  2IAU A;  4FZH A;  4IMB A;  2XCY A;  1W0P A;  1E8V A;  1F8C A;  3VNH A;  3O9K A;  3G4E A;  1NNC A;  2SIM A;  2DG0 A;  1DIM A;  4CPO A;  1IVG A;  2F0Z A;  4JML A;  2AEP A;  2YA5 A;  3ALX A;  1WP5 A;  3SRE A;  3UC1 A;  5D9B A;  3AMS A;  3KGG A;  1IUB A;  3SAL A;  1BJI A;  3GVJ A;  5FNT A;  3U0S A;  4MWL A;  3H72 A;  4K1H A;  4GZT A;  4Q6K A;  4L7B A;  2VW1 A;  3NN9 A;  4K1J A;  5FNU A;  2IVZ A;  4CPZ A;  1U6D X;  1CRZ A;  1L7G A;  1Q7F A;  4QNP A;  4XOG A;  3NSS A;  1F8E A;  3V1S A;  3SAN A;  1Z4X A;  5FNQ A;  4HW6 A;  4L7C A;  2HTU A;  2JKB A;  1E1A A;  4XJZ A;  1NSB A;  4ASC A;  4NC5 A;  4DG6 A;  2FPC A;  3GVK A;  3SOQ A;  1NMA N;  3TI4 A;  2VSM A;  2WOZ A;  3K36 A;  1QBI A;  3TIC A;  5GX5 A;  4FOY A;  4D52 C;  4GN7 A;  1SLL A;  1NCD N;  1INH A;  1ZGK A;  2POO A;  2F11 A;  1INV A;  1V2I A;  2X9M A;  4GJT A;  1EUT A;  2XZJ A;  4G3N A;  1W8O A;  3O9J A;  1Z4V A;  3Q6K A;  4XJU A;  4FPE A;  1SUU A;  4B7R A;  4D8S A;  4J9T A;  4FPK A;  1XOE A;  2VSK A;  4GZX A;  4XMA A;  2ISM A;  1MWE A;  3TI3 A;  4X49 A;  2VW0 A;  4WEG A;  3SIL A;  2XN4 A;  1EUR A;  2VAQ A;  4B7M A;  4KS1 A;  2BF6 A;  1MS4 A;  4GNB A;  1V3B A;  3E5Z A;  2VK5 A;  2QWD A;  3Q6P A;  2IAX A;  3BEQ A;  5D9D A;  3INB A;  2F26 A;  2HQS A;  1W8N A;  5GX4 A;  4MJU A;  4HHO A;  3K37 A;  4K1I A;  4IN4 A;  2YA4 A;  5GX2 A;  3SRG A;  2A75 A;  1KIT A;  3B69 A;  4XHB A;  5EO8 A;  2IAR A;  4GN8 A;  4HZX A;  4BBW A;  1IVC A;  1MZ5 A;  4HZY A;  3VNG A;  2VVZ A;  5F9T A;  3ZGC A;  4O5S A;  1MS8 A;  2HTV A;  2CML A;  5D9C A;  2VPJ A;  2GVU A;  3HRP A;  3IAX A;  4L7D A;  4CHB A;  4HZZ A;  2F27 A;  4X47 A;  1NCA N;  2HT5 A;  2YA7 A;  5CGJ A;  1NNA A;  4NN9 A;  2SIL A;  1CRU A;  5JYY A;  3H73 A;  3Q6T A;  1IVE A;  2F24 A;  3D11 A;  4FOW A;  3P5B L;  2IAT A;  2QWG A;  4IFN X;  1CQ1 A;  2XZK A;  2QWC A;  1X2R A;  4FPF A;  2QWI A;  3TI6 A;  4UF7 A;  4D52 A;  2QWF A;  2AH2 A;  4YZ3 A;  4DGR A;  3CL0 A;  3HLH A;  1B9V A;  4B7J A;  2DYH A;  1V0E A;  1NN2 A;  4IQK A;  4H52 A;  4IYG A;  2YA6 A;  5HUG A;  2C4A A;  4FPH A;  4M3M A;  1SNT A;  1F8B A;  4QN6 A;  2F28 A;  4HZV A;  2GVV A;  1VCJ A;  3K38 A;  4FPY A;  3V64 C;  3S2K A;  1E8T A;  3NO0 A;  4M4V A;  4X6K A;  4GZP A;  2HT7 A;  3A9H A;  2GHS A;  4I00 A;  1C5K A;  4MJV A;  4XYX A;  3PJQ A;  1NCB N;  4X4A A;  4GDJ A;  4MC7 A;  4MWR A;  4XJA A;  2F12 A;  3WW9 A;  1S0I A;  3LI5 A;  3FVZ A;  4FOV A;  2QWA A;  1RWL A;  4MWQ A;  1N1S A;  4Q1U A;  1N1V A;  2W20 A;  4GB1 A;  1MS0 A;  5M1Z A;  1QLG A;  1MS1 A;  1IVF A;  1RWI A;  2QWE A;  5FNR A;  1A14 N;  3ADE A;  2IAS A;  4GZS A;  4XIO A;  1USX A;  4GNA A;  1WCQ A;  2H2U A;  4YZ1 A;  4XE9 A;  1V3E A;  1N6F A;  1E8U A;  4XHX A;  3LI4 A;  4FP3 A;  1EUS A;  3TI5 A;  4ZGC A;  3S94 A;  1NSD A;  2IAP A;  2G8S A;  5GTQ A;  3A72 A;  5FZJ A;  3H6J A;  4SLI A;  4XMB A;  2B8H A;  4YW4 A;  7NN9 A;  4YW1 A;  3K3A A;  4FP2 A;  1XOG A;  2HTW A;  5HX0 A;  4C1Y A;  1Z4Z A;  4CH9 A;  1MS5 A;  4MZE A;  2RKC A;  3G4H A;  2ZWA A;  2W38 A;  2OJH A;  3D12 A;  3CL2 A;  4XJQ A;  1IJQ A;  1INF A;  4QN5 A;  1NMC A;  1IVD A;  2W8B A;  3L6V A;  1V3D A;  4B7N A;  4HZW A;  4MWU A;  3SOV A;  2IAQ A;  1PJX A;  1NNB A;  2VWD A;  2HU4 A;  3A71 A;  4CPN A;  1MS9 A;  4D52 B;  4HIZ A;  3DR2 A;  4FPC A;  5EX7 A;  4PWZ A;  2HTQ A;  4CSD A;  2BAT A;  2BER A;  4GZW A;  3K39 A;  4IFL X;  2VW2 A;  3S8Z A;  2C4L A;  1S0J A;  1N6E A;  2AEQ A;  1S1D A;  2QWJ A;  3W09 A;  1W20 A;  2IAW A;  4HHQ A;  5NN9 A;  1NPE A;  3HLI A;  1NSC A;  4XIL A;  4MWV A;  1V0Z A;  1V0F A;  1DIL A;  4FOQ A;  1W21 A;  4FPG A;  2ZB5 A;  4ZY3 A;  1WCS A;  1B9S A;  2HU0 A;  5FZN A;  4YZ2 A; 
#chains in the Genus database with same CATH homology
 4IFJ A;  5FNR A;  2DYH A;  3ADE A;  4L7D A;  4CHB A;  4IN4 A;  5FNS A;  5FNU A;  4IQK A;  3ZGD A;  1U6D X;  2Z32 A;  5CGJ A;  1ZGK A;  2XN4 A;  2ZZK A;  4CH9 A;  5FNQ A;  3VNH A;  3II7 A;  3WN7 A;  4L7C A;  2FLU X;  2ZWA A;  4ZY3 A;  2ZW9 A;  4IFL X;  4IFN X;  4ASC A;  3VNG A;  4ZGC A;  5F72 C;  3WDZ A;  1X2J A;  1X2R A;  5FZN A;  3ZGC A;  4YY8 A;  5FNT A;  5FZJ A;  2WOZ A;  4N1B A;  4XMB A;  2VPJ A;  4L7B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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