2VPJA

Crystal structure of the kelch domain of human klhl12
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
289
structure length
289
Chain Sequence
ANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords KELCH-LIKE PROTEIN 12
total genus 62
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2008-02-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 2vpjA00
3II7A 4L7BA 3VNHA 5FNSA 4CH9A 4IFJA 2ZW9A 3WN7A 1X2JA 4L7CA 2VPJA 3ADEA 4ZGCA 2FLUX 4IQKA 4N1BA 3WDZA 4YY8A 5CGJA 4IFLX 5FZJA 4ASCA 4IN4A 3ZGCA 2ZZKA 5FNRA 2WOZA 4ZY3A 5FZNA 4IFNX 2XN4A 2Z32A 2ZWAA 4L7DA 5FNTA 3ZGDA 5FNUA 4CHBA 5F72C 2DYHA 5FNQA 1U6DX 1ZGKA 1X2RA 3VNGA 4XMBA
chains in the Genus database with same CATH superfamily
1MS9A 5GX1A 1INWA 1NNCA 4C1YA 4R40A 1N1TA 4K1KA 3A9GA 3SLIA 1W1XA 4M4VA 4CPLA 1B9SA 1N7DA 2VPJA 1IVDA 1INYA 3V64C 4XJQA 4XMAA 2F26A 5B2CA 2WOZA 4FZHA 1XOEA 1S0IA 3NN9A 1Z4YA 2IAQA 4QN3A 4O5TA 3U0SA 3H71A 5HUMA 5HUGA 1V3CA 4CHBA 4MWUA 1Z50A 4X49A 3S8VA 5GTQA 1NCBN 3S2KA 4WA4A 4MX0A 1Z4WA 2ZB5A 2QWBA 3DR2A 3WWAA 2B8HA 1BJIA 3II7A 1NMCA 3TI5A 2VK5A 3CL0A 1USXA 2IASA 2F27A 4XJRA 3TI8A 3G4EA 1V3BA 3ADEA 4CPOA 3TIBA 1N6EA 2OJHA 1MS3A 4HZVA 4K1HA 2HU4A 4XJAA 4KS3A 5FNTA 1NNBA 3JU4A 2VW1A 5FNQA 4XILA 3GVLA 3VNGA 1IVGA 5HUNA 1INFA 1W8NA 1MS1A 4XYXA 4GZOA 4ZLRA 3WN7A 3BEQA 1NCDN 1S1DA 3B7EA 4FPHA 3A9HA 5D9BA 4MWWA 4YZ2A 4QN5A 2IARA 4B7MA 3H72A 4ZY3A 4XOGA 2CMLA 4CPNA 2Z32A 1V3DA 3SRGA 3CKZA 2VW0A 2AGSA 1WCSA 2X9MA 4D8SA 4MWRA 1NNAA 1IVBA 2POOA 3O4PA 1DIMA 1MZ6A 3GVKA 4K1JA 5B2DA 1IVFA 4HZWA 4YZ5A 2W8BB 2QWDA 4FOVA 1MS0A 2HU0A 4GEZA 4MWQA 4FPOB 4B7JA 3K3AA 4H52A 2W38A 4SLIA 1F8CA 1E8UA 1ZGKA 3TI3A 3K37A 5FZNA 3Q6PA 1IUCA 4YW4A 1NCAN 2VAQA 4WA5A 4HZZA 1N6FA 4MWVA 3ALXA 2F29A 1MS8A 3S94A 4HIZA 1Q7FA 3NSSA 5JYYA 2ZZKA 5FNRA 5NN9A 2H2NA 1W0OA 3Q6KA 2YA6A 4D52C 4GDIA 3INBA 4GZWA 5D9CA 1SO7A 1U6DX 1WCQA 1V04A 2QWAA 2F24A 1F8DA 1QBIA 1CRZA 4AGTA 3KGGA 4CH9A 4FPKA 4J9TA 1USRA 4AHAA 3H73A 4YY8A 4N1BA 2W20A 3Q6TA 4IFLX 2FPBA 2QWCA 4MC7A 2VVZA 2YA8A 2XCYA 2BATA 3P5BL 1MZ5A 2VSKA 4D4UA 3ZGDA 4Q6KA 1IVCA 3K38A 5F72C 2C4AA 1V2IA 2IAUA 4GZSA 1W21A 4K1IA 1XOGA 2SLIA 2C4LA 3I1CA 5GX4A 1ZI0A 2HQSA 2BERA 4UF7A 4XIOA 2AH2A 5CGJA 4GN9A 1L7HA 2IAVA 2RKCA 3AMRA 4FJ6A 4A0PA 1EUSA 1VCJA 4IFNX 3ALWA 3TI4A 4B7NA 2HT7A 5FNUA 4GJTA 4GNAA 3A71A 1IVEA 4M3MA 3LI4A 3KYAA 1EURA 2IAPA 4L7BA 4GNCA 3VNHA 2AEPA 1NSBA 1MR5A 4XJ9A 3B69A 2SIMA 3AMSA 2IVZA 3WDZA 3TI6A 3FW0A 1N6DA 2FHRA 4NC5A 4IN4A 4DGRA 2V91A 4MWXA 5FWWA 5GX3A 2ZWAA 4L7DA 2QWEA 4D52B 2F25A 5D9DA 2HTVA 1IUBA 5FZJA 3HLIA 4AH4A 5EX7A 1B9TA 4GN8A 4KS4A 4M4UA 3K39A 2G8SA 1PJXA 1NCCN 1W0PA 4MZAA 4XJUA 1X2JA 2BF6A 2QWGA 2F28A 1C5KA 7NN9A 1SLIA 3GVJA 2ISMA 2QE8A 3FVZA 3L6VA 2VK7A 2IAWA 1SUUA 2FP8A 5EO7A 2A75A 4YW5A 1INXA 3SALA 3CL2A 1E8TA 1V0FA 4JMLA 4M4NA 5GX5A 1POOA 1S18A 5EO8A 4WA3A 1EUUA 2ZW9A 1SNTA 2BZDA 3LI5A 2IAXA 4XHBA 1W20A 5HUKA 2IAOA 1F8BA 4I00A 3V1SA 3O9KA 3HLHA 4NCSA 2QWIA 4XJZA 2YDTA 3V65B 4IMBA 4YW1A 1X2RA 4X47A 6NN9A 4MJVA 4FPYA 3T1EA 2YDPA 4HHOA 5FNSA 1L7FA 2HTWA 1WP5A 2HT5A 1S0JA 2VK6A 3E5ZA 4YZ4A 4QN6A 1RWLA 2IATA 2W5OA 4G3NA 1CRUA 4MJUA 4JF7A 1V0EA 4FOQA 4FQ4A 3TICA 2GVWA 4HZXA 4K3YA 3S8ZA 2HT8A 4Q1UA 4FPGA 4O5SA 1MS5A 1N1SA 4WEGA 3UC1A 1INGA 1V3EA 4WEFA 3H6JA 4BBWA 2XZJA 4IFJA 3W09A 1VCUA 4KS1A 1N1VA 2W5NA 4IQKA 1N1YA 2P4OA 2F10A 4X6KA 4XE9A 4XJ8A 2VW2A 4GNBA 2JKBA 2QWFA 1QLGA 4MZEA 4QNPA 4IYGA 3D12A 4D52A 1A4QA 1NN2A 1DILA 3HRPA 3LI3A 2XZKA 2GVUA 5F9TA 4XMBA 2F0ZA 4GZXA 2DG1A 3D11A 2QWHA 2F11A 4FPFA 4DG6A 4C1YB 1MS4A 3A72A 4YZ3A 4FP3A 1A14N 4CPYA 4L7CA 3WW9A 2VWDA 4FP2A 2W8BA 3PJQA 1RWIA 1Z4ZA 3SOBB 3ZGCA 3CYEA 1SLLA 2FPCA 5GX2A 1EUTA 2H2UA 2DG0A 2XN4A 5H47A 3IAXA 4CPZA 4AGIA 4UOUA 4HHQA 2YA7A 1CVMA 4KS2A 2YA5A 4QN4A 1NSCA 4FOWA 4FVKA 1NMAN 4CPMA 4KS5A 4QN7A 4XJWA 2VSMA 3NO0A 1F8EA 1KITA 3SREA 4FPLA 1V0ZA 1IJQA 3TC9A 2XZIA 2GVVA 1INHA 2FP9A 3O9JA 4GDJA 3G4HA 4H53A 1A4GA 3SILA 1MWEA 1CQ1A 3OPZA 1K32A 1NPEA 1Z4XA 1OFZA 4FPJA 1E1AA 1Z4VA 4ASCA 4X4AA 2YA4A 1C9UA 4XHXA 2HTYA 4HZYA 4YW2A 4YW3A 3SANA 1NSDA 2GVXA 2QWJA 4FPEA 5HX0A 4PWZA 4CSDA 4XIKA 1NMBN 4MWYA 4GZTA 2DYHA 4MWJA 4GZQA 3SOQA 4FPCA 4B7QA 3DASA 2DSOA 3BYCA 2SILA 4XMIA 4B7RA 2QWKA 2HTRA 4GB1A 4ZGCA 2FLUX 4YZ1A 2AEQA 4GZPA 2HTUA 1B9VA 3SOVA 2ZB6A 2F12A 1L7GA 1W8OA 3TIAA 4NN9A 4FOYA 1INVA 1E8VA 2F13A 4GN7A 1H6LA 4HW6A 3K36A 2HTQA 4MWLA 2GHSA 5M1ZA
chains in the Genus database with same CATH topology
3II7A 4L7BA 3VNHA 5FNSA 4CH9A 4IFJA 2ZW9A 3WN7A 1X2JA 4L7CA 2VPJA 3ADEA 4ZGCA 2FLUX 4IQKA 4N1BA 3WDZA 4YY8A 5CGJA 4IFLX 5FZJA 4ASCA 4IN4A 3ZGCA 2ZZKA 5FNRA 2WOZA 4ZY3A 5FZNA 4IFNX 2XN4A 2Z32A 2ZWAA 4L7DA 5FNTA 3ZGDA 5FNUA 4CHBA 5F72C 2DYHA 5FNQA 1U6DX 1ZGKA 1X2RA 3VNGA 4XMBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3II7 A;  4L7B A;  3VNH A;  5FNS A;  4CH9 A;  4IFJ A;  2ZW9 A;  3WN7 A;  1X2J A;  4L7C A;  2VPJ A;  3ADE A;  4ZGC A;  2FLU X;  4IQK A;  4N1B A;  3WDZ A;  4YY8 A;  5CGJ A;  4IFL X;  5FZJ A;  4ASC A;  4IN4 A;  3ZGC A;  2ZZK A;  5FNR A;  2WOZ A;  4ZY3 A;  5FZN A;  4IFN X;  2XN4 A;  2Z32 A;  2ZWA A;  4L7D A;  5FNT A;  3ZGD A;  5FNU A;  4CHB A;  5F72 C;  2DYH A;  5FNQ A;  1U6D X;  1ZGK A;  1X2R A;  3VNG A;  4XMB A; 
#chains in the Genus database with same CATH topology
 1MS9 A;  5GX1 A;  1INW A;  1NNC A;  4C1Y A;  4R40 A;  1N1T A;  4K1K A;  3A9G A;  3SLI A;  1W1X A;  4M4V A;  4CPL A;  1B9S A;  1N7D A;  2VPJ A;  1IVD A;  1INY A;  3V64 C;  4XJQ A;  4XMA A;  2F26 A;  5B2C A;  2WOZ A;  4FZH A;  1XOE A;  1S0I A;  3NN9 A;  1Z4Y A;  2IAQ A;  4QN3 A;  4O5T A;  3U0S A;  3H71 A;  5HUM A;  5HUG A;  1V3C A;  4CHB A;  4MWU A;  1Z50 A;  4X49 A;  3S8V A;  5GTQ A;  1NCB N;  3S2K A;  4WA4 A;  4MX0 A;  1Z4W A;  2ZB5 A;  2QWB A;  3DR2 A;  3WWA A;  2B8H A;  1BJI A;  3II7 A;  1NMC A;  3TI5 A;  2VK5 A;  3CL0 A;  1USX A;  2IAS A;  2F27 A;  4XJR A;  3TI8 A;  3G4E A;  1V3B A;  3ADE A;  4CPO A;  3TIB A;  1N6E A;  2OJH A;  1MS3 A;  4HZV A;  4K1H A;  2HU4 A;  4XJA A;  4KS3 A;  5FNT A;  1NNB A;  3JU4 A;  2VW1 A;  5FNQ A;  4XIL A;  3GVL A;  3VNG A;  1IVG A;  5HUN A;  1INF A;  1W8N A;  1MS1 A;  4XYX A;  4GZO A;  4ZLR A;  3WN7 A;  3BEQ A;  1NCD N;  1S1D A;  3B7E A;  4FPH A;  3A9H A;  5D9B A;  4MWW A;  4YZ2 A;  4QN5 A;  2IAR A;  4B7M A;  3H72 A;  4ZY3 A;  4XOG A;  2CML A;  4CPN A;  2Z32 A;  1V3D A;  3SRG A;  3CKZ A;  2VW0 A;  2AGS A;  1WCS A;  2X9M A;  4D8S A;  4MWR A;  1NNA A;  1IVB A;  2POO A;  3O4P A;  1DIM A;  1MZ6 A;  3GVK A;  4K1J A;  5B2D A;  1IVF A;  4HZW A;  4YZ5 A;  2W8B B;  2QWD A;  4FOV A;  1MS0 A;  2HU0 A;  4GEZ A;  4MWQ A;  4FPO B;  4B7J A;  3K3A A;  4H52 A;  2W38 A;  4SLI A;  1F8C A;  1E8U A;  1ZGK A;  3TI3 A;  3K37 A;  5FZN A;  3Q6P A;  1IUC A;  4YW4 A;  1NCA N;  2VAQ A;  4WA5 A;  4HZZ A;  1N6F A;  4MWV A;  3ALX A;  2F29 A;  1MS8 A;  3S94 A;  4HIZ A;  1Q7F A;  3NSS A;  5JYY A;  2ZZK A;  5FNR A;  5NN9 A;  2H2N A;  1W0O A;  3Q6K A;  2YA6 A;  4D52 C;  4GDI A;  3INB A;  4GZW A;  5D9C A;  1SO7 A;  1U6D X;  1WCQ A;  1V04 A;  2QWA A;  2F24 A;  1F8D A;  1QBI A;  1CRZ A;  4AGT A;  3KGG A;  4CH9 A;  4FPK A;  4J9T A;  1USR A;  4AHA A;  3H73 A;  4YY8 A;  4N1B A;  2W20 A;  3Q6T A;  4IFL X;  2FPB A;  2QWC A;  4MC7 A;  2VVZ A;  2YA8 A;  2XCY A;  2BAT A;  3P5B L;  1MZ5 A;  2VSK A;  4D4U A;  3ZGD A;  4Q6K A;  1IVC A;  3K38 A;  5F72 C;  2C4A A;  1V2I A;  2IAU A;  4GZS A;  1W21 A;  4K1I A;  1XOG A;  2SLI A;  2C4L A;  3I1C A;  5GX4 A;  1ZI0 A;  2HQS A;  2BER A;  4UF7 A;  4XIO A;  2AH2 A;  5CGJ A;  4GN9 A;  1L7H A;  2IAV A;  2RKC A;  3AMR A;  4FJ6 A;  4A0P A;  1EUS A;  1VCJ A;  4IFN X;  3ALW A;  3TI4 A;  4B7N A;  2HT7 A;  5FNU A;  4GJT A;  4GNA A;  3A71 A;  1IVE A;  4M3M A;  3LI4 A;  3KYA A;  1EUR A;  2IAP A;  4L7B A;  4GNC A;  3VNH A;  2AEP A;  1NSB A;  1MR5 A;  4XJ9 A;  3B69 A;  2SIM A;  3AMS A;  2IVZ A;  3WDZ A;  3TI6 A;  3FW0 A;  1N6D A;  2FHR A;  4NC5 A;  4IN4 A;  4DGR A;  2V91 A;  4MWX A;  5FWW A;  5GX3 A;  2ZWA A;  4L7D A;  2QWE A;  4D52 B;  2F25 A;  5D9D A;  2HTV A;  1IUB A;  5FZJ A;  3HLI A;  4AH4 A;  5EX7 A;  1B9T A;  4GN8 A;  4KS4 A;  4M4U A;  3K39 A;  2G8S A;  1PJX A;  1NCC N;  1W0P A;  4MZA A;  4XJU A;  1X2J A;  2BF6 A;  2QWG A;  2F28 A;  1C5K A;  7NN9 A;  1SLI A;  3GVJ A;  2ISM A;  2QE8 A;  3FVZ A;  3L6V A;  2VK7 A;  2IAW A;  1SUU A;  2FP8 A;  5EO7 A;  2A75 A;  4YW5 A;  1INX A;  3SAL A;  3CL2 A;  1E8T A;  1V0F A;  4JML A;  4M4N A;  5GX5 A;  1POO A;  1S18 A;  5EO8 A;  4WA3 A;  1EUU A;  2ZW9 A;  1SNT A;  2BZD A;  3LI5 A;  2IAX A;  4XHB A;  1W20 A;  5HUK A;  2IAO A;  1F8B A;  4I00 A;  3V1S A;  3O9K A;  3HLH A;  4NCS A;  2QWI A;  4XJZ A;  2YDT A;  3V65 B;  4IMB A;  4YW1 A;  1X2R A;  4X47 A;  6NN9 A;  4MJV A;  4FPY A;  3T1E A;  2YDP A;  4HHO A;  5FNS A;  1L7F A;  2HTW A;  1WP5 A;  2HT5 A;  1S0J A;  2VK6 A;  3E5Z A;  4YZ4 A;  4QN6 A;  1RWL A;  2IAT A;  2W5O A;  4G3N A;  1CRU A;  4MJU A;  4JF7 A;  1V0E A;  4FOQ A;  4FQ4 A;  3TIC A;  2GVW A;  4HZX A;  4K3Y A;  3S8Z A;  2HT8 A;  4Q1U A;  4FPG A;  4O5S A;  1MS5 A;  1N1S A;  4WEG A;  3UC1 A;  1ING A;  1V3E A;  4WEF A;  3H6J A;  4BBW A;  2XZJ A;  4IFJ A;  3W09 A;  1VCU A;  4KS1 A;  1N1V A;  2W5N A;  4IQK A;  1N1Y A;  2P4O A;  2F10 A;  4X6K A;  4XE9 A;  4XJ8 A;  2VW2 A;  4GNB A;  2JKB A;  2QWF A;  1QLG A;  4MZE A;  4QNP A;  4IYG A;  3D12 A;  4D52 A;  1A4Q A;  1NN2 A;  1DIL A;  3HRP A;  3LI3 A;  2XZK A;  2GVU A;  5F9T A;  4XMB A;  2F0Z A;  4GZX A;  2DG1 A;  3D11 A;  2QWH A;  2F11 A;  4FPF A;  4DG6 A;  4C1Y B;  1MS4 A;  3A72 A;  4YZ3 A;  4FP3 A;  1A14 N;  4CPY A;  4L7C A;  3WW9 A;  2VWD A;  4FP2 A;  2W8B A;  3PJQ A;  1RWI A;  1Z4Z A;  3SOB B;  3ZGC A;  3CYE A;  1SLL A;  2FPC A;  5GX2 A;  1EUT A;  2H2U A;  2DG0 A;  2XN4 A;  5H47 A;  3IAX A;  4CPZ A;  4AGI A;  4UOU A;  4HHQ A;  2YA7 A;  1CVM A;  4KS2 A;  2YA5 A;  4QN4 A;  1NSC A;  4FOW A;  4FVK A;  1NMA N;  4CPM A;  4KS5 A;  4QN7 A;  4XJW A;  2VSM A;  3NO0 A;  1F8E A;  1KIT A;  3SRE A;  4FPL A;  1V0Z A;  1IJQ A;  3TC9 A;  2XZI A;  2GVV A;  1INH A;  2FP9 A;  3O9J A;  4GDJ A;  3G4H A;  4H53 A;  1A4G A;  3SIL A;  1MWE A;  1CQ1 A;  3OPZ A;  1K32 A;  1NPE A;  1Z4X A;  1OFZ A;  4FPJ A;  1E1A A;  1Z4V A;  4ASC A;  4X4A A;  2YA4 A;  1C9U A;  4XHX A;  2HTY A;  4HZY A;  4YW2 A;  4YW3 A;  3SAN A;  1NSD A;  2GVX A;  2QWJ A;  4FPE A;  5HX0 A;  4PWZ A;  4CSD A;  4XIK A;  1NMB N;  4MWY A;  4GZT A;  2DYH A;  4MWJ A;  4GZQ A;  3SOQ A;  4FPC A;  4B7Q A;  3DAS A;  2DSO A;  3BYC A;  2SIL A;  4XMI A;  4B7R A;  2QWK A;  2HTR A;  4GB1 A;  4ZGC A;  2FLU X;  4YZ1 A;  2AEQ A;  4GZP A;  2HTU A;  1B9V A;  3SOV A;  2ZB6 A;  2F12 A;  1L7G A;  1W8O A;  3TIA A;  4NN9 A;  4FOY A;  1INV A;  1E8V A;  2F13 A;  4GN7 A;  1H6L A;  4HW6 A;  3K36 A;  2HTQ A;  4MWL A;  2GHS A;  5M1Z A; 
#chains in the Genus database with same CATH homology
 3II7 A;  4L7B A;  3VNH A;  5FNS A;  4CH9 A;  4IFJ A;  2ZW9 A;  3WN7 A;  1X2J A;  4L7C A;  2VPJ A;  3ADE A;  4ZGC A;  2FLU X;  4IQK A;  4N1B A;  3WDZ A;  4YY8 A;  5CGJ A;  4IFL X;  5FZJ A;  4ASC A;  4IN4 A;  3ZGC A;  2ZZK A;  5FNR A;  2WOZ A;  4ZY3 A;  5FZN A;  4IFN X;  2XN4 A;  2Z32 A;  2ZWA A;  4L7D A;  5FNT A;  3ZGD A;  5FNU A;  4CHB A;  5F72 C;  2DYH A;  5FNQ A;  1U6D X;  1ZGK A;  1X2R A;  3VNG A;  4XMB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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