2XN4A

Crystal structure of the kelch domain of human klhl2 (mayven)
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
286
structure length
286
Chain Sequence
PKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDVASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Structural protein
source organism Homo sapiens
publication title Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
pubmed doi rcsb
molecule keywords KELCH-LIKE PROTEIN 2
total genus 62
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 2xn4A00
5CGJA 2DYHA 3VNGA 4IQKA 2ZZKA 1X2JA 4ZGCA 1U6DX 4IFNX 4CH9A 4IN4A 5FNRA 2WOZA 1X2RA 4L7DA 2ZWAA 2Z32A 2VPJA 3ADEA 4N1BA 5FZJA 3WDZA 5FNSA 5FNTA 1ZGKA 5FZNA 4L7BA 5FNQA 2XN4A 4YY8A 4L7CA 2FLUX 4ZY3A 3VNHA 4ASCA 3ZGCA 3ZGDA 5F72C 4IFJA 4IFLX 3II7A 4XMBA 3WN7A 4CHBA 5FNUA 2ZW9A
chains in the Genus database with same CATH superfamily
1NMAN 4GZTA 4GZQA 4GNCA 1MS8A 2SILA 1IVCA 1IVEA 2IVZA 2WOZA 4FQ4A 4MWUA 1V0ZA 3BEQA 4B7NA 2HTQA 3WW9A 1MR5A 1C9UA 4MWRA 4AH4A 1CRUA 1DIMA 2QWFA 5B2CA 2VSKA 4YY8A 4K3YA 4D8SA 3Q6TA 4M4UA 3V65B 2BATA 4HHQA 3SOBB 4MJUA 4GNAA 4GN8A 7NN9A 1MS4A 4FPHA 3P5BL 3S94A 2W5NA 3TI4A 3SREA 1INVA 1BJIA 1IVGA 4A0PA 2HU0A 2QWJA 4QN6A 2QE8A 3LI5A 2YA4A 2ZB6A 2YA5A 3UC1A 1SLIA 1IVDA 1W20A 1INFA 1MS5A 4MWJA 3VNHA 4MZAA 3K3AA 1KITA 2IAOA 4XJRA 4IFLX 3II7A 2AH2A 2QWEA 1B9VA 2ZW9A 4YZ3A 2GHSA 3TC9A 3H6JA 4XHBA 3GVJA 2F28A 3WWAA 2DSOA 1MZ6A 1L7HA 4CPLA 3TICA 2OJHA 4Q1UA 1W21A 3AMSA 5H47A 1K32A 4WA3A 2H2UA 1QLGA 4B7MA 4KS4A 4FP3A 2FPBA 2W8BA 1W8OA 2HT5A 4IMBA 3DR2A 5NN9A 4NC5A 1NCCN 1SO7A 1SLLA 3FW0A 4NCSA 4UOUA 2AEQA 2QWDA 4CPOA 1A14N 1F8DA 3AMRA 1INYA 4KS3A 1N6EA 3WDZA 2G8SA 5FNSA 1MWEA 5FZNA 4B7RA 1NMCA 3OPZA 4FPJA 5GX5A 3A71A 4X47A 2C4LA 3T1EA 2VVZA 1V3DA 4XILA 5GX3A 5HUMA 4MWQA 1NSBA 4FP2A 4FPYA 2QWCA 3ALXA 1NNCA 4CHBA 3H71A 2GVUA 1ZI0A 1E8UA 1EUTA 4HZZA 5HUNA 1S0JA 1NPEA 2AEPA 1N1YA 4SLIA 5D9BA 4XJWA 2QWBA 4GB1A 1INXA 1IVBA 4FOVA 4X6KA 5FNQA 4HIZA 2IARA 2HTVA 1Z4ZA 4GEZA 2IAQA 3ZGDA 2POOA 4QN5A 3FVZA 3TI5A 5M1ZA 4GDJA 4J9TA 2GVXA 1NN2A 4YZ2A 4QN3A 2QWKA 4AGTA 3LI4A 4GN7A 3SRGA 4GNBA 3SOVA 2F12A 4MJVA 2XN4A 4Q6KA 5JYYA 3ZGCA 2FHRA 4WA5A 1Z4WA 1N6DA 1N1SA 2QWGA 5FNUA 4ZLRA 3D11A 3BYCA 3KGGA 4MZEA 3SOQA 4IYGA 1X2JA 4MWXA 4XIKA 3S2KA 4C1YB 4FPFA 4XOGA 2C4AA 2DG1A 4XHXA 4XJAA 2IAUA 1CRZA 2ZWAA 3ADEA 2F26A 3O4PA 4K1IA 1N1VA 2P4OA 4L7BA 1E8VA 4YZ4A 3V1SA 3W09A 3CL2A 3O9KA 4K1JA 3V64C 4D52B 4ZY3A 2VWDA 2F11A 4ASCA 2V91A 3Q6KA 4K1KA 4X4AA 3L6VA 4GDIA 5EO8A 1W0PA 1N1TA 2DYHA 1S1DA 2VK6A 4MC7A 4CSDA 1INHA 2VK7A 5HX0A 1Z50A 2SLIA 4KS1A 3TIBA 1V04A 2IAWA 4YW1A 4YW4A 3G4HA 3SALA 2VSMA 4GN9A 5FWWA 2BERA 2YA7A 3SLIA 3LI3A 1F8BA 4HZVA 4XJ9A 1WCSA 4M4NA 4XE9A 3KYAA 3S8VA 3TI3A 3K38A 1V0FA 2JKBA 4G3NA 4CPNA 5F72C 3G4EA 2A75A 2F13A 4YZ5A 1SUUA 2B8HA 4PWZA 3CL0A 3VNGA 6NN9A 2FP9A 2VK5A 5D9DA 1Z4YA 2VW1A 3O9JA 2HT8A 3HRPA 2VAQA 1EUUA 3Q6PA 2IASA 1NSDA 4GZOA 2IAVA 1USXA 1N7DA 3NN9A 4WEFA 4XMBA 3DASA 3WN7A 2HTYA 1S0IA 3SILA 5CGJA 5EO7A 4MWLA 3B7EA 1NCAN 2SIMA 3D12A 1C5KA 2FPCA 2HTUA 1Z4XA 4CPZA 3S8ZA 1MS9A 2XZKA 4D52C 1H6LA 3CYEA 4FOQA 4GZSA 1IUCA 2F0ZA 3H72A 5HUGA 2BZDA 3SANA 2QWAA 4AHAA 4AGIA 4O5TA 2RKCA 1XOGA 4HZWA 1Z4VA 2HTRA 4HZYA 4HHOA 3PJQA 2HQSA 1V0EA 2W8BB 4DGRA 5GX4A 2QWHA 4GZWA 4O5SA 4XJZA 2GVWA 4XMIA 4BBWA 1OFZA 2IAPA 2XZIA 4XMAA 4HZXA 5D9CA 2HTWA 2F10A 2CMLA 1VCUA 5GX2A 2W5OA 1A4QA 4XJQA 2GVVA 2YA6A 1QBIA 5HUKA 4MWVA 4IQKA 1EUSA 4XJ8A 1U6DX 4CPMA 1CQ1A 3K37A 4B7JA 1DILA 2Z32A 2ZB5A 1MS1A 4GJTA 1E1AA 4FPGA 5FNTA 2FP8A 4FPLA 1ZGKA 1IUBA 1INWA 2AGSA 3K36A 3A9HA 1VCJA 3HLHA 3HLIA 1E8TA 4XIOA 1NMBN 2YDPA 4IFNX 5FNRA 1X2RA 2XZJA 4UF7A 4H52A 3IAXA 2HT7A 1W0OA 1NNAA 4WEGA 4L7CA 4FJ6A 4QN7A 3H73A 3A72A 1V3CA 4HW6A 1F8CA 4IFJA 4QNPA 4M4VA 4CPYA 2F29A 4MX0A 5F9TA 4FZHA 4YW3A 1L7FA 4ZGCA 4IN4A 3E5ZA 1NCDN 1B9SA 4YZ1A 4MWWA 4X49A 1B9TA 3CKZA 1POOA 4N1BA 1XOEA 1IVFA 1V3EA 1W1XA 5FZJA 1NSCA 2VW2A 2QWIA 3TI6A 4FPEA 2IAXA 3INBA 4WA4A 3ALWA 4H53A 4QN4A 2X9MA 2F25A 4JMLA 2F27A 4XYXA 1IJQA 4FPOB 3U0SA 3GVLA 4GZPA 4YW5A 3B69A 2ZZKA 4MWYA 4CH9A 5GX1A 4FPCA 4B7QA 5GTQA 4L7DA 3TIAA 3NO0A 1SNTA 2VW0A 4GZXA 1WCQA 2VPJA 4FVKA 3I1CA 4XJUA 1L7GA 1F8EA 2FLUX 3K39A 3NSSA 1V2IA 1NNBA 4R40A 4C1YA 1RWLA 2HU4A 4FOYA 3TI8A 1RWIA 3A9GA 1MZ5A 2H2NA 1W8NA 2W38A 1NCBN 1Q7FA 2F24A 4DG6A 2YA8A 1PJXA 4YW2A 1A4GA 2XCYA 1EURA 4K1HA 4FPKA 2YDTA 4D52A 4KS5A 5EX7A 2DG0A 4D4UA 5B2DA 1MS0A 3GVKA 1USRA 4I00A 4NN9A 1CVMA 4FOWA 4M3MA 1V3BA 2ISMA 1WP5A 1N6FA 4KS2A 1INGA 3JU4A 2BF6A 2IATA 1S18A 1MS3A 4JF7A 2W20A
chains in the Genus database with same CATH topology
5CGJA 2DYHA 3VNGA 4IQKA 2ZZKA 1X2JA 4ZGCA 1U6DX 4IFNX 4CH9A 4IN4A 5FNRA 2WOZA 1X2RA 4L7DA 2ZWAA 2Z32A 2VPJA 3ADEA 4N1BA 5FZJA 3WDZA 5FNSA 5FNTA 1ZGKA 5FZNA 4L7BA 5FNQA 2XN4A 4YY8A 4L7CA 2FLUX 4ZY3A 3VNHA 4ASCA 3ZGCA 3ZGDA 5F72C 4IFJA 4IFLX 3II7A 4XMBA 3WN7A 4CHBA 5FNUA 2ZW9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CGJ A;  2DYH A;  3VNG A;  4IQK A;  2ZZK A;  1X2J A;  4ZGC A;  1U6D X;  4IFN X;  4CH9 A;  4IN4 A;  5FNR A;  2WOZ A;  1X2R A;  4L7D A;  2ZWA A;  2Z32 A;  2VPJ A;  3ADE A;  4N1B A;  5FZJ A;  3WDZ A;  5FNS A;  5FNT A;  1ZGK A;  5FZN A;  4L7B A;  5FNQ A;  2XN4 A;  4YY8 A;  4L7C A;  2FLU X;  4ZY3 A;  3VNH A;  4ASC A;  3ZGC A;  3ZGD A;  5F72 C;  4IFJ A;  4IFL X;  3II7 A;  4XMB A;  3WN7 A;  4CHB A;  5FNU A;  2ZW9 A; 
#chains in the Genus database with same CATH topology
 1NMA N;  4GZT A;  4GZQ A;  4GNC A;  1MS8 A;  2SIL A;  1IVC A;  1IVE A;  2IVZ A;  2WOZ A;  4FQ4 A;  4MWU A;  1V0Z A;  3BEQ A;  4B7N A;  2HTQ A;  3WW9 A;  1MR5 A;  1C9U A;  4MWR A;  4AH4 A;  1CRU A;  1DIM A;  2QWF A;  5B2C A;  2VSK A;  4YY8 A;  4K3Y A;  4D8S A;  3Q6T A;  4M4U A;  3V65 B;  2BAT A;  4HHQ A;  3SOB B;  4MJU A;  4GNA A;  4GN8 A;  7NN9 A;  1MS4 A;  4FPH A;  3P5B L;  3S94 A;  2W5N A;  3TI4 A;  3SRE A;  1INV A;  1BJI A;  1IVG A;  4A0P A;  2HU0 A;  2QWJ A;  4QN6 A;  2QE8 A;  3LI5 A;  2YA4 A;  2ZB6 A;  2YA5 A;  3UC1 A;  1SLI A;  1IVD A;  1W20 A;  1INF A;  1MS5 A;  4MWJ A;  3VNH A;  4MZA A;  3K3A A;  1KIT A;  2IAO A;  4XJR A;  4IFL X;  3II7 A;  2AH2 A;  2QWE A;  1B9V A;  2ZW9 A;  4YZ3 A;  2GHS A;  3TC9 A;  3H6J A;  4XHB A;  3GVJ A;  2F28 A;  3WWA A;  2DSO A;  1MZ6 A;  1L7H A;  4CPL A;  3TIC A;  2OJH A;  4Q1U A;  1W21 A;  3AMS A;  5H47 A;  1K32 A;  4WA3 A;  2H2U A;  1QLG A;  4B7M A;  4KS4 A;  4FP3 A;  2FPB A;  2W8B A;  1W8O A;  2HT5 A;  4IMB A;  3DR2 A;  5NN9 A;  4NC5 A;  1NCC N;  1SO7 A;  1SLL A;  3FW0 A;  4NCS A;  4UOU A;  2AEQ A;  2QWD A;  4CPO A;  1A14 N;  1F8D A;  3AMR A;  1INY A;  4KS3 A;  1N6E A;  3WDZ A;  2G8S A;  5FNS A;  1MWE A;  5FZN A;  4B7R A;  1NMC A;  3OPZ A;  4FPJ A;  5GX5 A;  3A71 A;  4X47 A;  2C4L A;  3T1E A;  2VVZ A;  1V3D A;  4XIL A;  5GX3 A;  5HUM A;  4MWQ A;  1NSB A;  4FP2 A;  4FPY A;  2QWC A;  3ALX A;  1NNC A;  4CHB A;  3H71 A;  2GVU A;  1ZI0 A;  1E8U A;  1EUT A;  4HZZ A;  5HUN A;  1S0J A;  1NPE A;  2AEP A;  1N1Y A;  4SLI A;  5D9B A;  4XJW A;  2QWB A;  4GB1 A;  1INX A;  1IVB A;  4FOV A;  4X6K A;  5FNQ A;  4HIZ A;  2IAR A;  2HTV A;  1Z4Z A;  4GEZ A;  2IAQ A;  3ZGD A;  2POO A;  4QN5 A;  3FVZ A;  3TI5 A;  5M1Z A;  4GDJ A;  4J9T A;  2GVX A;  1NN2 A;  4YZ2 A;  4QN3 A;  2QWK A;  4AGT A;  3LI4 A;  4GN7 A;  3SRG A;  4GNB A;  3SOV A;  2F12 A;  4MJV A;  2XN4 A;  4Q6K A;  5JYY A;  3ZGC A;  2FHR A;  4WA5 A;  1Z4W A;  1N6D A;  1N1S A;  2QWG A;  5FNU A;  4ZLR A;  3D11 A;  3BYC A;  3KGG A;  4MZE A;  3SOQ A;  4IYG A;  1X2J A;  4MWX A;  4XIK A;  3S2K A;  4C1Y B;  4FPF A;  4XOG A;  2C4A A;  2DG1 A;  4XHX A;  4XJA A;  2IAU A;  1CRZ A;  2ZWA A;  3ADE A;  2F26 A;  3O4P A;  4K1I A;  1N1V A;  2P4O A;  4L7B A;  1E8V A;  4YZ4 A;  3V1S A;  3W09 A;  3CL2 A;  3O9K A;  4K1J A;  3V64 C;  4D52 B;  4ZY3 A;  2VWD A;  2F11 A;  4ASC A;  2V91 A;  3Q6K A;  4K1K A;  4X4A A;  3L6V A;  4GDI A;  5EO8 A;  1W0P A;  1N1T A;  2DYH A;  1S1D A;  2VK6 A;  4MC7 A;  4CSD A;  1INH A;  2VK7 A;  5HX0 A;  1Z50 A;  2SLI A;  4KS1 A;  3TIB A;  1V04 A;  2IAW A;  4YW1 A;  4YW4 A;  3G4H A;  3SAL A;  2VSM A;  4GN9 A;  5FWW A;  2BER A;  2YA7 A;  3SLI A;  3LI3 A;  1F8B A;  4HZV A;  4XJ9 A;  1WCS A;  4M4N A;  4XE9 A;  3KYA A;  3S8V A;  3TI3 A;  3K38 A;  1V0F A;  2JKB A;  4G3N A;  4CPN A;  5F72 C;  3G4E A;  2A75 A;  2F13 A;  4YZ5 A;  1SUU A;  2B8H A;  4PWZ A;  3CL0 A;  3VNG A;  6NN9 A;  2FP9 A;  2VK5 A;  5D9D A;  1Z4Y A;  2VW1 A;  3O9J A;  2HT8 A;  3HRP A;  2VAQ A;  1EUU A;  3Q6P A;  2IAS A;  1NSD A;  4GZO A;  2IAV A;  1USX A;  1N7D A;  3NN9 A;  4WEF A;  4XMB A;  3DAS A;  3WN7 A;  2HTY A;  1S0I A;  3SIL A;  5CGJ A;  5EO7 A;  4MWL A;  3B7E A;  1NCA N;  2SIM A;  3D12 A;  1C5K A;  2FPC A;  2HTU A;  1Z4X A;  4CPZ A;  3S8Z A;  1MS9 A;  2XZK A;  4D52 C;  1H6L A;  3CYE A;  4FOQ A;  4GZS A;  1IUC A;  2F0Z A;  3H72 A;  5HUG A;  2BZD A;  3SAN A;  2QWA A;  4AHA A;  4AGI A;  4O5T A;  2RKC A;  1XOG A;  4HZW A;  1Z4V A;  2HTR A;  4HZY A;  4HHO A;  3PJQ A;  2HQS A;  1V0E A;  2W8B B;  4DGR A;  5GX4 A;  2QWH A;  4GZW A;  4O5S A;  4XJZ A;  2GVW A;  4XMI A;  4BBW A;  1OFZ A;  2IAP A;  2XZI A;  4XMA A;  4HZX A;  5D9C A;  2HTW A;  2F10 A;  2CML A;  1VCU A;  5GX2 A;  2W5O A;  1A4Q A;  4XJQ A;  2GVV A;  2YA6 A;  1QBI A;  5HUK A;  4MWV A;  4IQK A;  1EUS A;  4XJ8 A;  1U6D X;  4CPM A;  1CQ1 A;  3K37 A;  4B7J A;  1DIL A;  2Z32 A;  2ZB5 A;  1MS1 A;  4GJT A;  1E1A A;  4FPG A;  5FNT A;  2FP8 A;  4FPL A;  1ZGK A;  1IUB A;  1INW A;  2AGS A;  3K36 A;  3A9H A;  1VCJ A;  3HLH A;  3HLI A;  1E8T A;  4XIO A;  1NMB N;  2YDP A;  4IFN X;  5FNR A;  1X2R A;  2XZJ A;  4UF7 A;  4H52 A;  3IAX A;  2HT7 A;  1W0O A;  1NNA A;  4WEG A;  4L7C A;  4FJ6 A;  4QN7 A;  3H73 A;  3A72 A;  1V3C A;  4HW6 A;  1F8C A;  4IFJ A;  4QNP A;  4M4V A;  4CPY A;  2F29 A;  4MX0 A;  5F9T A;  4FZH A;  4YW3 A;  1L7F A;  4ZGC A;  4IN4 A;  3E5Z A;  1NCD N;  1B9S A;  4YZ1 A;  4MWW A;  4X49 A;  1B9T A;  3CKZ A;  1POO A;  4N1B A;  1XOE A;  1IVF A;  1V3E A;  1W1X A;  5FZJ A;  1NSC A;  2VW2 A;  2QWI A;  3TI6 A;  4FPE A;  2IAX A;  3INB A;  4WA4 A;  3ALW A;  4H53 A;  4QN4 A;  2X9M A;  2F25 A;  4JML A;  2F27 A;  4XYX A;  1IJQ A;  4FPO B;  3U0S A;  3GVL A;  4GZP A;  4YW5 A;  3B69 A;  2ZZK A;  4MWY A;  4CH9 A;  5GX1 A;  4FPC A;  4B7Q A;  5GTQ A;  4L7D A;  3TIA A;  3NO0 A;  1SNT A;  2VW0 A;  4GZX A;  1WCQ A;  2VPJ A;  4FVK A;  3I1C A;  4XJU A;  1L7G A;  1F8E A;  2FLU X;  3K39 A;  3NSS A;  1V2I A;  1NNB A;  4R40 A;  4C1Y A;  1RWL A;  2HU4 A;  4FOY A;  3TI8 A;  1RWI A;  3A9G A;  1MZ5 A;  2H2N A;  1W8N A;  2W38 A;  1NCB N;  1Q7F A;  2F24 A;  4DG6 A;  2YA8 A;  1PJX A;  4YW2 A;  1A4G A;  2XCY A;  1EUR A;  4K1H A;  4FPK A;  2YDT A;  4D52 A;  4KS5 A;  5EX7 A;  2DG0 A;  4D4U A;  5B2D A;  1MS0 A;  3GVK A;  1USR A;  4I00 A;  4NN9 A;  1CVM A;  4FOW A;  4M3M A;  1V3B A;  2ISM A;  1WP5 A;  1N6F A;  4KS2 A;  1ING A;  3JU4 A;  2BF6 A;  2IAT A;  1S18 A;  1MS3 A;  4JF7 A;  2W20 A; 
#chains in the Genus database with same CATH homology
 5CGJ A;  2DYH A;  3VNG A;  4IQK A;  2ZZK A;  1X2J A;  4ZGC A;  1U6D X;  4IFN X;  4CH9 A;  4IN4 A;  5FNR A;  2WOZ A;  1X2R A;  4L7D A;  2ZWA A;  2Z32 A;  2VPJ A;  3ADE A;  4N1B A;  5FZJ A;  3WDZ A;  5FNS A;  5FNT A;  1ZGK A;  5FZN A;  4L7B A;  5FNQ A;  2XN4 A;  4YY8 A;  4L7C A;  2FLU X;  4ZY3 A;  3VNH A;  4ASC A;  3ZGC A;  3ZGD A;  5F72 C;  4IFJ A;  4IFL X;  3II7 A;  4XMB A;  3WN7 A;  4CHB A;  5FNU A;  2ZW9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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