2VPJA

Crystal structure of the kelch domain of human klhl12
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
289
structure length
289
Chain Sequence
ANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords KELCH-LIKE PROTEIN 12
total genus 62
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2008-02-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 2vpjA00
4CH9A 1U6DX 2FLUX 3ADEA 2Z32A 4ZY3A 3VNGA 2WOZA 1X2JA 5F72C 5FNUA 4YY8A 3WN7A 5FNRA 1X2RA 2ZWAA 3WDZA 4ASCA 2ZZKA 4L7DA 4ZGCA 3ZGDA 4L7BA 4IFLX 5FNTA 4XMBA 5FZNA 4IQKA 5FZJA 2XN4A 3VNHA 4IN4A 5CGJA 2ZW9A 1ZGKA 5FNQA 2DYHA 4IFNX 4N1BA 5FNSA 2VPJA 3ZGCA 4IFJA 4CHBA 4L7CA 3II7A
chains in the Genus database with same CATH superfamily
4CH9A 2AEPA 2BATA 3AMSA 4YW4A 4CPNA 4GZOA 1W0OA 2VAQA 3K38A 1IVBA 1MS8A 3DASA 3GVLA 2W20A 1N1VA 4NC5A 1QLGA 3K3AA 2C4AA 5EO7A 7NN9A 3CL2A 1E1AA 3NO0A 1S1DA 3E5ZA 3K36A 2FHRA 4XHBA 4FP2A 1XOGA 4D8SA 1NCDN 3D12A 4YZ1A 1N1SA 4CSDA 2A75A 1INVA 4YW2A 1INYA 2X9MA 4GNBA 4X4AA 1SNTA 2POOA 4FPOB 5NN9A 5HUGA 2C4LA 3ALWA 4WEFA 4ZY3A 4FPYA 3G4EA 1F8EA 5M1ZA 1INGA 4IYGA 2IARA 1INHA 5B2CA 1Z50A 2SLIA 2W5NA 3GVJA 2W8BA 1RWIA 4GN9A 1Z4VA 2G8SA 4KS3A 4KS2A 1OFZA 2HTYA 3I1CA 1E8TA 4FPJA 3SLIA 2BF6A 5FWWA 4MC7A 2QWGA 1V2IA 1W0PA 4D4UA 1W20A 1RWLA 2W8BB 1C5KA 3SOQA 2XCYA 4QN4A 4FPFA 4AH4A 2JKBA 2VSMA 3SANA 2H2UA 4XMIA 3TIBA 4QN7A 2B8HA 5HX0A 1K32A 2VK7A 4FP3A 4B7MA 4NCSA 3FVZA 3B69A 4MWVA 3VNHA 2XN4A 4K1JA 4WA4A 4R40A 2IAUA 4PWZA 4M3MA 5JYYA 4K1IA 4HZYA 4IFJA 2YDPA 3II7A 2QWCA 4HZWA 4M4UA 4XYXA 1MS1A 3CYEA 1X2JA 1B9VA 3AMRA 1V04A 2QWIA 4I00A 3K39A 5D9DA 2VW0A 3IAXA 1NMBN 2F13A 4XIKA 4CPZA 1NSCA 2VVZA 4GZTA 1NSBA 1IJQA 4FQ4A 4HIZA 5EO8A 2AGSA 4K3YA 4IFNX 2HT8A 4J9TA 4MZAA 3TC9A 5B2DA 2VW2A 1N6EA 3H72A 4MWLA 4XMAA 2WOZA 2HTQA 5H47A 3DR2A 1MZ6A 2IAQA 1VCJA 2SILA 1SLIA 4X47A 5FNRA 4H53A 2RKCA 2DG1A 1XOEA 1CRUA 4UOUA 2F10A 4FPGA 1Z4ZA 4XJUA 3ZGDA 4IFLX 3Q6TA 5GX1A 5FZJA 2YA7A 1INFA 2W38A 1H6LA 2P4OA 2HT7A 4MZEA 1WCQA 4ZGCA 1MR5A 4FOQA 5GTQA 4C1YB 1IVCA 4FOVA 4HZVA 1SLLA 2F0ZA 2IVZA 2QWAA 1MS9A 1USRA 4X49A 3K37A 4MWQA 1IVGA 1NMAN 1S18A 3A9GA 4MWRA 2F25A 2XZKA 4XILA 1NCCN 2F29A 4DGRA 2FPCA 1Q7FA 1ZI0A 1F8CA 1KITA 1EUUA 4GZWA 4MJUA 1DILA 2F28A 3FW0A 2ZB5A 4FPCA 5FNUA 4YY8A 1A4GA 3WN7A 4AHAA 3HLIA 4H52A 3WDZA 2H2NA 5GX4A 3O9JA 3CKZA 1B9SA 3UC1A 1IVFA 1NNAA 4GZSA 3P5BL 4XMBA 3B7EA 5GX2A 4IQKA 3S2KA 4FPHA 4XHXA 4K1HA 4K1KA 5FNSA 4GZQA 2ZZKA 1U6DX 1SUUA 1IVEA 2AEQA 4FPEA 2SIMA 4AGTA 2W5OA 1VCUA 4CPYA 1W8OA 4L7DA 5FNTA 1S0JA 2YA4A 1W21A 2V91A 2IAOA 2QWJA 2HT5A 1INWA 5HUNA 3INBA 4IN4A 2ISMA 2HTVA 4Q1UA 4QN3A 1C9UA 1USXA 2VPJA 4HZZA 3A71A 2HU4A 4B7QA 3G4HA 4UF7A 4D52C 4FJ6A 4GZXA 3W09A 1N1TA 4FPKA 3WWAA 2F12A 3SOVA 4NN9A 1MS5A 3SRGA 2IAWA 4KS1A 1F8BA 1QBIA 2QWEA 2VSKA 4XJAA 1V0ZA 3S94A 1EUTA 4GN7A 1E8VA 1IUBA 1W1XA 4KS5A 2YA6A 1DIMA 2AH2A 1S0IA 4XJ8A 4DG6A 1INXA 5CGJA 3NSSA 3ZGCA 1Z4WA 3TICA 3BEQA 3TI3A 1W8NA 5EX7A 1L7GA 3T1EA 2ZB6A 1NN2A 3HLHA 3SALA 1NCBN 4MWJA 1POOA 1X2RA 2ZWAA 1BJIA 4XJRA 3V65B 2QE8A 2FP8A 1CRZA 4C1YA 3H71A 4YZ4A 5FZNA 2HTRA 3H6JA 2F26A 1NNCA 1NPEA 1WCSA 2QWHA 4M4VA 4N1BA 2GHSA 1A4QA 2FLUX 2BZDA 2QWFA 2F24A 1N6DA 2CMLA 3V64C 2GVWA 2GVVA 2VK5A 4YZ5A 4AGIA 2VW1A 4GNAA 2QWKA 4YZ2A 3S8VA 4MWWA 1EUSA 1MZ5A 5HUKA 4GN8A 4WEGA 4YW3A 4CPOA 2GVUA 1EURA 4QNPA 2YDTA 1N1YA 5FNQA 4MWXA 1V3CA 1Z4XA 5GX5A 1IVDA 4X6KA 3A9HA 5F72C 1V3EA 4O5SA 3TI5A 1CVMA 1NCAN 4XE9A 4HHQA 3L6VA 4XOGA 4Q6KA 1V0EA 2IAPA 4HW6A 4IMBA 5GX3A 2IASA 3ALXA 1NMCA 3A72A 4FPLA 2VK6A 2FP9A 2ZW9A 1ZGKA 2HTWA 4MWYA 3BYCA 3WW9A 5HUMA 6NN9A 1MWEA 3TI6A 3PJQA 4G3NA 2QWBA 1IUCA 3V1SA 4O5TA 3TI8A 4HZXA 4ASCA 4XJQA 5D9CA 2XZIA 3JU4A 4L7BA 1N6FA 4MWUA 2IAXA 3S8ZA 4FVKA 3OPZA 4CPMA 4YZ3A 5D9BA 3SOBB 3TI4A 2FPBA 4CPLA 4QN5A 4XJZA 3KYAA 3O4PA 4XJWA 3SREA 4QN6A 1V0FA 3VNGA 4ZLRA 4B7NA 2HU0A 1L7HA 3O9KA 4GB1A 3Q6PA 4XJ9A 4YW5A 2YA8A 3U0SA 3CL0A 1V3BA 3LI5A 1MS4A 2BERA 4GDIA 3NN9A 4MJVA 4BBWA 5F9TA 2YA5A 1CQ1A 2HQSA 1E8UA 2F27A 2DG0A 4MX0A 2F11A 3LI4A 1MS0A 2HTUA 4YW1A 1NNBA 4GNCA 2Z32A 3GVKA 1F8DA 4GEZA 4GZPA 4HHOA 4FOYA 3LI3A 3TIAA 1V3DA 4XIOA 1NSDA 1L7FA 3SILA 1N7DA 4WA3A 1A14N 2OJHA 1SO7A 4D52A 2DYHA 4GDJA 4SLIA 1WP5A 3ADEA 2QWDA 4M4NA 2XZJA 4A0PA 4B7JA 1Z4YA 4B7RA 3HRPA 2IATA 4FOWA 1B9TA 4KS4A 4GJTA 4JMLA 4WA5A 3Q6KA 4JF7A 2DSOA 4D52B 2GVXA 1MS3A 4FZHA 2VWDA 3D11A 2IAVA 3H73A 3KGGA 4CHBA 1PJXA 4L7CA
chains in the Genus database with same CATH topology
4CH9A 1U6DX 2FLUX 3ADEA 2Z32A 4ZY3A 3VNGA 2WOZA 1X2JA 5F72C 5FNUA 4YY8A 3WN7A 5FNRA 1X2RA 2ZWAA 3WDZA 4ASCA 2ZZKA 4L7DA 4ZGCA 3ZGDA 4L7BA 4IFLX 5FNTA 4XMBA 5FZNA 4IQKA 5FZJA 2XN4A 3VNHA 4IN4A 5CGJA 2ZW9A 1ZGKA 5FNQA 2DYHA 4IFNX 4N1BA 5FNSA 2VPJA 3ZGCA 4IFJA 4CHBA 4L7CA 3II7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CH9 A;  1U6D X;  2FLU X;  3ADE A;  2Z32 A;  4ZY3 A;  3VNG A;  2WOZ A;  1X2J A;  5F72 C;  5FNU A;  4YY8 A;  3WN7 A;  5FNR A;  1X2R A;  2ZWA A;  3WDZ A;  4ASC A;  2ZZK A;  4L7D A;  4ZGC A;  3ZGD A;  4L7B A;  4IFL X;  5FNT A;  4XMB A;  5FZN A;  4IQK A;  5FZJ A;  2XN4 A;  3VNH A;  4IN4 A;  5CGJ A;  2ZW9 A;  1ZGK A;  5FNQ A;  2DYH A;  4IFN X;  4N1B A;  5FNS A;  2VPJ A;  3ZGC A;  4IFJ A;  4CHB A;  4L7C A;  3II7 A; 
#chains in the Genus database with same CATH topology
 4CH9 A;  2AEP A;  2BAT A;  3AMS A;  4YW4 A;  4CPN A;  4GZO A;  1W0O A;  2VAQ A;  3K38 A;  1IVB A;  1MS8 A;  3DAS A;  3GVL A;  2W20 A;  1N1V A;  4NC5 A;  1QLG A;  3K3A A;  2C4A A;  5EO7 A;  7NN9 A;  3CL2 A;  1E1A A;  3NO0 A;  1S1D A;  3E5Z A;  3K36 A;  2FHR A;  4XHB A;  4FP2 A;  1XOG A;  4D8S A;  1NCD N;  3D12 A;  4YZ1 A;  1N1S A;  4CSD A;  2A75 A;  1INV A;  4YW2 A;  1INY A;  2X9M A;  4GNB A;  4X4A A;  1SNT A;  2POO A;  4FPO B;  5NN9 A;  5HUG A;  2C4L A;  3ALW A;  4WEF A;  4ZY3 A;  4FPY A;  3G4E A;  1F8E A;  5M1Z A;  1ING A;  4IYG A;  2IAR A;  1INH A;  5B2C A;  1Z50 A;  2SLI A;  2W5N A;  3GVJ A;  2W8B A;  1RWI A;  4GN9 A;  1Z4V A;  2G8S A;  4KS3 A;  4KS2 A;  1OFZ A;  2HTY A;  3I1C A;  1E8T A;  4FPJ A;  3SLI A;  2BF6 A;  5FWW A;  4MC7 A;  2QWG A;  1V2I A;  1W0P A;  4D4U A;  1W20 A;  1RWL A;  2W8B B;  1C5K A;  3SOQ A;  2XCY A;  4QN4 A;  4FPF A;  4AH4 A;  2JKB A;  2VSM A;  3SAN A;  2H2U A;  4XMI A;  3TIB A;  4QN7 A;  2B8H A;  5HX0 A;  1K32 A;  2VK7 A;  4FP3 A;  4B7M A;  4NCS A;  3FVZ A;  3B69 A;  4MWV A;  3VNH A;  2XN4 A;  4K1J A;  4WA4 A;  4R40 A;  2IAU A;  4PWZ A;  4M3M A;  5JYY A;  4K1I A;  4HZY A;  4IFJ A;  2YDP A;  3II7 A;  2QWC A;  4HZW A;  4M4U A;  4XYX A;  1MS1 A;  3CYE A;  1X2J A;  1B9V A;  3AMR A;  1V04 A;  2QWI A;  4I00 A;  3K39 A;  5D9D A;  2VW0 A;  3IAX A;  1NMB N;  2F13 A;  4XIK A;  4CPZ A;  1NSC A;  2VVZ A;  4GZT A;  1NSB A;  1IJQ A;  4FQ4 A;  4HIZ A;  5EO8 A;  2AGS A;  4K3Y A;  4IFN X;  2HT8 A;  4J9T A;  4MZA A;  3TC9 A;  5B2D A;  2VW2 A;  1N6E A;  3H72 A;  4MWL A;  4XMA A;  2WOZ A;  2HTQ A;  5H47 A;  3DR2 A;  1MZ6 A;  2IAQ A;  1VCJ A;  2SIL A;  1SLI A;  4X47 A;  5FNR A;  4H53 A;  2RKC A;  2DG1 A;  1XOE A;  1CRU A;  4UOU A;  2F10 A;  4FPG A;  1Z4Z A;  4XJU A;  3ZGD A;  4IFL X;  3Q6T A;  5GX1 A;  5FZJ A;  2YA7 A;  1INF A;  2W38 A;  1H6L A;  2P4O A;  2HT7 A;  4MZE A;  1WCQ A;  4ZGC A;  1MR5 A;  4FOQ A;  5GTQ A;  4C1Y B;  1IVC A;  4FOV A;  4HZV A;  1SLL A;  2F0Z A;  2IVZ A;  2QWA A;  1MS9 A;  1USR A;  4X49 A;  3K37 A;  4MWQ A;  1IVG A;  1NMA N;  1S18 A;  3A9G A;  4MWR A;  2F25 A;  2XZK A;  4XIL A;  1NCC N;  2F29 A;  4DGR A;  2FPC A;  1Q7F A;  1ZI0 A;  1F8C A;  1KIT A;  1EUU A;  4GZW A;  4MJU A;  1DIL A;  2F28 A;  3FW0 A;  2ZB5 A;  4FPC A;  5FNU A;  4YY8 A;  1A4G A;  3WN7 A;  4AHA A;  3HLI A;  4H52 A;  3WDZ A;  2H2N A;  5GX4 A;  3O9J A;  3CKZ A;  1B9S A;  3UC1 A;  1IVF A;  1NNA A;  4GZS A;  3P5B L;  4XMB A;  3B7E A;  5GX2 A;  4IQK A;  3S2K A;  4FPH A;  4XHX A;  4K1H A;  4K1K A;  5FNS A;  4GZQ A;  2ZZK A;  1U6D X;  1SUU A;  1IVE A;  2AEQ A;  4FPE A;  2SIM A;  4AGT A;  2W5O A;  1VCU A;  4CPY A;  1W8O A;  4L7D A;  5FNT A;  1S0J A;  2YA4 A;  1W21 A;  2V91 A;  2IAO A;  2QWJ A;  2HT5 A;  1INW A;  5HUN A;  3INB A;  4IN4 A;  2ISM A;  2HTV A;  4Q1U A;  4QN3 A;  1C9U A;  1USX A;  2VPJ A;  4HZZ A;  3A71 A;  2HU4 A;  4B7Q A;  3G4H A;  4UF7 A;  4D52 C;  4FJ6 A;  4GZX A;  3W09 A;  1N1T A;  4FPK A;  3WWA A;  2F12 A;  3SOV A;  4NN9 A;  1MS5 A;  3SRG A;  2IAW A;  4KS1 A;  1F8B A;  1QBI A;  2QWE A;  2VSK A;  4XJA A;  1V0Z A;  3S94 A;  1EUT A;  4GN7 A;  1E8V A;  1IUB A;  1W1X A;  4KS5 A;  2YA6 A;  1DIM A;  2AH2 A;  1S0I A;  4XJ8 A;  4DG6 A;  1INX A;  5CGJ A;  3NSS A;  3ZGC A;  1Z4W A;  3TIC A;  3BEQ A;  3TI3 A;  1W8N A;  5EX7 A;  1L7G A;  3T1E A;  2ZB6 A;  1NN2 A;  3HLH A;  3SAL A;  1NCB N;  4MWJ A;  1POO A;  1X2R A;  2ZWA A;  1BJI A;  4XJR A;  3V65 B;  2QE8 A;  2FP8 A;  1CRZ A;  4C1Y A;  3H71 A;  4YZ4 A;  5FZN A;  2HTR A;  3H6J A;  2F26 A;  1NNC A;  1NPE A;  1WCS A;  2QWH A;  4M4V A;  4N1B A;  2GHS A;  1A4Q A;  2FLU X;  2BZD A;  2QWF A;  2F24 A;  1N6D A;  2CML A;  3V64 C;  2GVW A;  2GVV A;  2VK5 A;  4YZ5 A;  4AGI A;  2VW1 A;  4GNA A;  2QWK A;  4YZ2 A;  3S8V A;  4MWW A;  1EUS A;  1MZ5 A;  5HUK A;  4GN8 A;  4WEG A;  4YW3 A;  4CPO A;  2GVU A;  1EUR A;  4QNP A;  2YDT A;  1N1Y A;  5FNQ A;  4MWX A;  1V3C A;  1Z4X A;  5GX5 A;  1IVD A;  4X6K A;  3A9H A;  5F72 C;  1V3E A;  4O5S A;  3TI5 A;  1CVM A;  1NCA N;  4XE9 A;  4HHQ A;  3L6V A;  4XOG A;  4Q6K A;  1V0E A;  2IAP A;  4HW6 A;  4IMB A;  5GX3 A;  2IAS A;  3ALX A;  1NMC A;  3A72 A;  4FPL A;  2VK6 A;  2FP9 A;  2ZW9 A;  1ZGK A;  2HTW A;  4MWY A;  3BYC A;  3WW9 A;  5HUM A;  6NN9 A;  1MWE A;  3TI6 A;  3PJQ A;  4G3N A;  2QWB A;  1IUC A;  3V1S A;  4O5T A;  3TI8 A;  4HZX A;  4ASC A;  4XJQ A;  5D9C A;  2XZI A;  3JU4 A;  4L7B A;  1N6F A;  4MWU A;  2IAX A;  3S8Z A;  4FVK A;  3OPZ A;  4CPM A;  4YZ3 A;  5D9B A;  3SOB B;  3TI4 A;  2FPB A;  4CPL A;  4QN5 A;  4XJZ A;  3KYA A;  3O4P A;  4XJW A;  3SRE A;  4QN6 A;  1V0F A;  3VNG A;  4ZLR A;  4B7N A;  2HU0 A;  1L7H A;  3O9K A;  4GB1 A;  3Q6P A;  4XJ9 A;  4YW5 A;  2YA8 A;  3U0S A;  3CL0 A;  1V3B A;  3LI5 A;  1MS4 A;  2BER A;  4GDI A;  3NN9 A;  4MJV A;  4BBW A;  5F9T A;  2YA5 A;  1CQ1 A;  2HQS A;  1E8U A;  2F27 A;  2DG0 A;  4MX0 A;  2F11 A;  3LI4 A;  1MS0 A;  2HTU A;  4YW1 A;  1NNB A;  4GNC A;  2Z32 A;  3GVK A;  1F8D A;  4GEZ A;  4GZP A;  4HHO A;  4FOY A;  3LI3 A;  3TIA A;  1V3D A;  4XIO A;  1NSD A;  1L7F A;  3SIL A;  1N7D A;  4WA3 A;  1A14 N;  2OJH A;  1SO7 A;  4D52 A;  2DYH A;  4GDJ A;  4SLI A;  1WP5 A;  3ADE A;  2QWD A;  4M4N A;  2XZJ A;  4A0P A;  4B7J A;  1Z4Y A;  4B7R A;  3HRP A;  2IAT A;  4FOW A;  1B9T A;  4KS4 A;  4GJT A;  4JML A;  4WA5 A;  3Q6K A;  4JF7 A;  2DSO A;  4D52 B;  2GVX A;  1MS3 A;  4FZH A;  2VWD A;  3D11 A;  2IAV A;  3H73 A;  3KGG A;  4CHB A;  1PJX A;  4L7C A; 
#chains in the Genus database with same CATH homology
 4CH9 A;  1U6D X;  2FLU X;  3ADE A;  2Z32 A;  4ZY3 A;  3VNG A;  2WOZ A;  1X2J A;  5F72 C;  5FNU A;  4YY8 A;  3WN7 A;  5FNR A;  1X2R A;  2ZWA A;  3WDZ A;  4ASC A;  2ZZK A;  4L7D A;  4ZGC A;  3ZGD A;  4L7B A;  4IFL X;  5FNT A;  4XMB A;  5FZN A;  4IQK A;  5FZJ A;  2XN4 A;  3VNH A;  4IN4 A;  5CGJ A;  2ZW9 A;  1ZGK A;  5FNQ A;  2DYH A;  4IFN X;  4N1B A;  5FNS A;  2VPJ A;  3ZGC A;  4IFJ A;  4CHB A;  4L7C A;  3II7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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