2XN4A

Crystal structure of the kelch domain of human klhl2 (mayven)
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
286
structure length
286
Chain Sequence
PKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDVASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords KELCH-LIKE PROTEIN 2
total genus 62
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 2xn4A00
3ZGCA 5FNUA 3VNGA 4L7DA 1ZGKA 4ZGCA 4N1BA 2Z32A 5F72C 5FNTA 2FLUX 4ZY3A 3II7A 3WN7A 4IFNX 5FZJA 4CH9A 2ZWAA 2ZZKA 4IFJA 4YY8A 2WOZA 5FNQA 3VNHA 2XN4A 4CHBA 5CGJA 4IFLX 4L7CA 2DYHA 5FNSA 1X2JA 3WDZA 5FZNA 5FNRA 4IQKA 3ZGDA 1U6DX 4XMBA 2ZW9A 4IN4A 4ASCA 2VPJA 1X2RA 4L7BA 3ADEA
chains in the Genus database with same CATH superfamily
3S8VA 4M4NA 4K1JA 2QWCA 3BYCA 2FLUX 4FVKA 5HX0A 4PWZA 2C4LA 2POOA 3V64C 2VVZA 3B7EA 2FPCA 2H2NA 4CHBA 1MS0A 4L7CA 1Z4ZA 1E8VA 1X2JA 3CKZA 3K3AA 2F0ZA 2GVWA 1IVCA 4B7RA 4FP3A 1W8NA 1V0ZA 2F25A 2QE8A 4QN3A 4X49A 5B2DA 1OFZA 4BBWA 2F11A 2GVUA 4XHBA 3SREA 3AMSA 5H47A 4B7NA 1W21A 4X6KA 3WN7A 4HZYA 1NNCA 3A71A 1F8EA 4NC5A 1S18A 2W20A 1IVGA 4YZ4A 1MS4A 4JMLA 5GX5A 4XJUA 2IVZA 2ZW9A 4FP2A 4IN4A 3Q6KA 2QWEA 3WW9A 4GZXA 1X2RA 3O4PA 4KS1A 3SOVA 3E5ZA 1USXA 1INGA 3CL0A 2YA5A 2ZB5A 3K39A 4FQ4A 3GVJA 5D9CA 4MWLA 1NMAN 4CPOA 4FOVA 2P4OA 2ZZKA 3H72A 4B7QA 3FVZA 3TI8A 5FWWA 3WDZA 2AH2A 2HQSA 4O5SA 1IUCA 4NCSA 4HIZA 4MWWA 4YW2A 4ZLRA 2YA6A 4HZXA 1N1SA 2VPJA 3ZGCA 1PJXA 1INXA 5D9DA 3UC1A 2QWAA 4QN6A 4XJZA 2RKCA 3D12A 3SRGA 1INWA 4FPFA 1QBIA 3TC9A 4YY8A 1F8DA 4YW1A 3V1SA 4R40A 4FZHA 4FOWA 4YZ1A 4FPKA 2BATA 1INFA 1E1AA 1EURA 1MR5A 2XZJA 2F29A 3TICA 4K1KA 2W8BA 4HHOA 4CPLA 4AHAA 1INYA 2CMLA 3VNGA 1Z4XA 1MS8A 4D52B 2IAPA 1E8TA 4IYGA 4UOUA 3A9GA 1V04A 1USRA 4M4UA 4A0PA 3GVLA 4IFNX 3LI3A 4C1YB 4CH9A 4JF7A 1Q7FA 4GZPA 4WEGA 2IAXA 1NCBN 3OPZA 2FPBA 2W5NA 2IAUA 2BZDA 2V91A 1V3DA 4MWXA 2F26A 5GTQA 4D52A 4AGTA 3TIBA 4GZTA 4K3YA 4XMBA 2FP8A 3P5BL 1S0JA 2C4AA 3ALWA 4C1YA 2HT7A 5HUNA 5B2CA 3ADEA 4GN7A 4QN5A 4L7DA 4ZGCA 3SOQA 4GEZA 3D11A 4GDJA 3CYEA 5F72C 1B9TA 1V2IA 1MZ6A 6NN9A 4DG6A 4AGIA 1DILA 2VW2A 5FNQA 2QWKA 1MWEA 5NN9A 1MS9A 2DYHA 5EO7A 1A14N 4I00A 4IMBA 4CSDA 4IQKA 3TI3A 4J9TA 1SNTA 4K1IA 1N7DA 4WA4A 2GVVA 3L6VA 5M1ZA 4K1HA 3TI4A 4UF7A 4ASCA 2VK7A 2SILA 1RWLA 4FOYA 4MZAA 3INBA 3TI6A 2G8SA 4D4UA 3NSSA 4MZEA 2XN4A 4XIOA 4GN8A 2VK6A 1N6FA 1RWIA 2QWIA 2YA8A 2BF6A 2SLIA 5FNRA 1WCQA 1Z4VA 1WP5A 3NN9A 4FPOB 2DG0A 1N6EA 4O5TA 5D9BA 2QWJA 1N6DA 4QN4A 1IVBA 2F28A 5FNUA 4MWYA 1VCJA 3S2KA 1IJQA 3S8ZA 4B7MA 5FNTA 2IASA 2HT5A 4Q1UA 5FZJA 4FPHA 4MWVA 4GB1A 4QN7A 5EX7A 5EO8A 4AH4A 4XIKA 2QWFA 2WOZA 4WA5A 4CPMA 1QLGA 3WWAA 3FW0A 2F10A 5HUGA 3TI5A 1NCCN 1Z50A 4YW3A 3TIAA 4GJTA 1V0FA 4KS5A 4FPYA 1N1YA 2W5OA 1NCDN 1WCSA 2XCYA 4MX0A 4MJVA 4XJWA 1KITA 2X9MA 2W8BB 1W0PA 1W8OA 1IVDA 4XHXA 2YDTA 1NSBA 3H73A 4YZ5A 1B9VA 2HU0A 2HTYA 2VSMA 3KYAA 4XJAA 1K32A 2QWBA 3O9JA 4HW6A 4MWQA 1E8UA 4GDIA 3W09A 2OJHA 3SILA 2DSOA 4KS4A 1C5KA 4XYXA 1L7GA 1SLLA 3O9KA 4Q6KA 1SUUA 2HTUA 3LI4A 3II7A 4CPNA 1A4GA 2HTQA 1W1XA 2FP9A 3CL2A 5CGJA 2QWGA 1CRZA 2HTWA 1B9SA 3SOBB 4GN9A 3BEQA 4CPZA 2QWHA 4XJ9A 1SO7A 4HZWA 2IAVA 4HZZA 1A4QA 4KS3A 3K37A 3KGGA 2IATA 1NSCA 3A72A 4GZSA 2F13A 4FPGA 4N1BA 2YDPA 1L7HA 4MWUA 3IAXA 4XJQA 1NMBN 5HUMA 1NSDA 3LI5A 3AMRA 4X47A 1CQ1A 3Q6TA 4FOQA 4XE9A 2W38A 2QWDA 1XOEA 1W0OA 1NN2A 3A9HA 4XMAA 5GX3A 3K36A 3SALA 1ZI0A 1W20A 1DIMA 1ZGKA 3HLHA 4M3MA 1INHA 3NO0A 1EUTA 4ZY3A 3V65B 1L7FA 4XMIA 3H71A 2A75A 2VW0A 2VSKA 1V3EA 1F8BA 1MS5A 4XOGA 4XJRA 5GX2A 4KS2A 5HUKA 4GNBA 5GX4A 2H2UA 1CVMA 1V3CA 2YA4A 3PJQA 1EUUA 1N1TA 4L7BA 2DG1A 2F12A 3SANA 5JYYA 4FPCA 4GNAA 1NNAA 3SLIA 3GVKA 2IARA 2XZKA 2F24A 2VWDA 4GZQA 2XZIA 4SLIA 4XILA 3ALXA 4IFLX 2IAQA 1MS3A 3U0SA 4MC7A 1EUSA 4HHQA 1V3BA 3B69A 4GZWA 4XJ8A 1BJIA 2HTVA 3G4HA 1POOA 1NPEA 2GVXA 1NNBA 1NCAN 2ZWAA 1IVFA 3HRPA 1SLIA 1VCUA 4IFJA 5GX1A 3Q6PA 4DGRA 1CRUA 2F27A 4D52C 4YZ2A 2VAQA 4GZOA 4GNCA 4YW4A 4B7JA 3K38A 4FPJA 4X4AA 1U6DX 1S0IA 4H53A 1N1VA 4QNPA 1IVEA 2VK5A 4MWRA 4D8SA 1MS1A 3HLIA 2JKBA 4FJ6A 1F8CA 1MZ5A 4MWJA 1Z4YA 3JU4A 1XOGA 2HT8A 1C9UA 4M4VA 1H6LA 2ISMA 5FZNA 3I1CA 1V0EA 4G3NA 2YA7A 7NN9A 3G4EA 3ZGDA 2VW1A 4CPYA 3T1EA 3DASA 1NMCA 2BERA 1Z4WA 3DR2A 4HZVA 2FHRA 2Z32A 4H52A 2GHSA 4MJUA 2AEQA 2ZB6A 2AGSA 4NN9A 3H6JA 1S1DA 3VNHA 4YW5A 2HTRA 2HU4A 5FNSA 2IAWA 4WEFA 4WA3A 5F9TA 1IUBA 2B8HA 4FPLA 2AEPA 4FPEA 2SIMA 4YZ3A 1INVA 2IAOA 3S94A
chains in the Genus database with same CATH topology
3ZGCA 5FNUA 3VNGA 4L7DA 1ZGKA 4ZGCA 4N1BA 2Z32A 5F72C 5FNTA 2FLUX 4ZY3A 3II7A 3WN7A 4IFNX 5FZJA 4CH9A 2ZWAA 2ZZKA 4IFJA 4YY8A 2WOZA 5FNQA 3VNHA 2XN4A 4CHBA 5CGJA 4IFLX 4L7CA 2DYHA 5FNSA 1X2JA 3WDZA 5FZNA 5FNRA 4IQKA 3ZGDA 1U6DX 4XMBA 2ZW9A 4IN4A 4ASCA 2VPJA 1X2RA 4L7BA 3ADEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZGC A;  5FNU A;  3VNG A;  4L7D A;  1ZGK A;  4ZGC A;  4N1B A;  2Z32 A;  5F72 C;  5FNT A;  2FLU X;  4ZY3 A;  3II7 A;  3WN7 A;  4IFN X;  5FZJ A;  4CH9 A;  2ZWA A;  2ZZK A;  4IFJ A;  4YY8 A;  2WOZ A;  5FNQ A;  3VNH A;  2XN4 A;  4CHB A;  5CGJ A;  4IFL X;  4L7C A;  2DYH A;  5FNS A;  1X2J A;  3WDZ A;  5FZN A;  5FNR A;  4IQK A;  3ZGD A;  1U6D X;  4XMB A;  2ZW9 A;  4IN4 A;  4ASC A;  2VPJ A;  1X2R A;  4L7B A;  3ADE A; 
#chains in the Genus database with same CATH topology
 3S8V A;  4M4N A;  4K1J A;  2QWC A;  3BYC A;  2FLU X;  4FVK A;  5HX0 A;  4PWZ A;  2C4L A;  2POO A;  3V64 C;  2VVZ A;  3B7E A;  2FPC A;  2H2N A;  4CHB A;  1MS0 A;  4L7C A;  1Z4Z A;  1E8V A;  1X2J A;  3CKZ A;  3K3A A;  2F0Z A;  2GVW A;  1IVC A;  4B7R A;  4FP3 A;  1W8N A;  1V0Z A;  2F25 A;  2QE8 A;  4QN3 A;  4X49 A;  5B2D A;  1OFZ A;  4BBW A;  2F11 A;  2GVU A;  4XHB A;  3SRE A;  3AMS A;  5H47 A;  4B7N A;  1W21 A;  4X6K A;  3WN7 A;  4HZY A;  1NNC A;  3A71 A;  1F8E A;  4NC5 A;  1S18 A;  2W20 A;  1IVG A;  4YZ4 A;  1MS4 A;  4JML A;  5GX5 A;  4XJU A;  2IVZ A;  2ZW9 A;  4FP2 A;  4IN4 A;  3Q6K A;  2QWE A;  3WW9 A;  4GZX A;  1X2R A;  3O4P A;  4KS1 A;  3SOV A;  3E5Z A;  1USX A;  1ING A;  3CL0 A;  2YA5 A;  2ZB5 A;  3K39 A;  4FQ4 A;  3GVJ A;  5D9C A;  4MWL A;  1NMA N;  4CPO A;  4FOV A;  2P4O A;  2ZZK A;  3H72 A;  4B7Q A;  3FVZ A;  3TI8 A;  5FWW A;  3WDZ A;  2AH2 A;  2HQS A;  4O5S A;  1IUC A;  4NCS A;  4HIZ A;  4MWW A;  4YW2 A;  4ZLR A;  2YA6 A;  4HZX A;  1N1S A;  2VPJ A;  3ZGC A;  1PJX A;  1INX A;  5D9D A;  3UC1 A;  2QWA A;  4QN6 A;  4XJZ A;  2RKC A;  3D12 A;  3SRG A;  1INW A;  4FPF A;  1QBI A;  3TC9 A;  4YY8 A;  1F8D A;  4YW1 A;  3V1S A;  4R40 A;  4FZH A;  4FOW A;  4YZ1 A;  4FPK A;  2BAT A;  1INF A;  1E1A A;  1EUR A;  1MR5 A;  2XZJ A;  2F29 A;  3TIC A;  4K1K A;  2W8B A;  4HHO A;  4CPL A;  4AHA A;  1INY A;  2CML A;  3VNG A;  1Z4X A;  1MS8 A;  4D52 B;  2IAP A;  1E8T A;  4IYG A;  4UOU A;  3A9G A;  1V04 A;  1USR A;  4M4U A;  4A0P A;  3GVL A;  4IFN X;  3LI3 A;  4C1Y B;  4CH9 A;  4JF7 A;  1Q7F A;  4GZP A;  4WEG A;  2IAX A;  1NCB N;  3OPZ A;  2FPB A;  2W5N A;  2IAU A;  2BZD A;  2V91 A;  1V3D A;  4MWX A;  2F26 A;  5GTQ A;  4D52 A;  4AGT A;  3TIB A;  4GZT A;  4K3Y A;  4XMB A;  2FP8 A;  3P5B L;  1S0J A;  2C4A A;  3ALW A;  4C1Y A;  2HT7 A;  5HUN A;  5B2C A;  3ADE A;  4GN7 A;  4QN5 A;  4L7D A;  4ZGC A;  3SOQ A;  4GEZ A;  3D11 A;  4GDJ A;  3CYE A;  5F72 C;  1B9T A;  1V2I A;  1MZ6 A;  6NN9 A;  4DG6 A;  4AGI A;  1DIL A;  2VW2 A;  5FNQ A;  2QWK A;  1MWE A;  5NN9 A;  1MS9 A;  2DYH A;  5EO7 A;  1A14 N;  4I00 A;  4IMB A;  4CSD A;  4IQK A;  3TI3 A;  4J9T A;  1SNT A;  4K1I A;  1N7D A;  4WA4 A;  2GVV A;  3L6V A;  5M1Z A;  4K1H A;  3TI4 A;  4UF7 A;  4ASC A;  2VK7 A;  2SIL A;  1RWL A;  4FOY A;  4MZA A;  3INB A;  3TI6 A;  2G8S A;  4D4U A;  3NSS A;  4MZE A;  2XN4 A;  4XIO A;  4GN8 A;  2VK6 A;  1N6F A;  1RWI A;  2QWI A;  2YA8 A;  2BF6 A;  2SLI A;  5FNR A;  1WCQ A;  1Z4V A;  1WP5 A;  3NN9 A;  4FPO B;  2DG0 A;  1N6E A;  4O5T A;  5D9B A;  2QWJ A;  1N6D A;  4QN4 A;  1IVB A;  2F28 A;  5FNU A;  4MWY A;  1VCJ A;  3S2K A;  1IJQ A;  3S8Z A;  4B7M A;  5FNT A;  2IAS A;  2HT5 A;  4Q1U A;  5FZJ A;  4FPH A;  4MWV A;  4GB1 A;  4QN7 A;  5EX7 A;  5EO8 A;  4AH4 A;  4XIK A;  2QWF A;  2WOZ A;  4WA5 A;  4CPM A;  1QLG A;  3WWA A;  3FW0 A;  2F10 A;  5HUG A;  3TI5 A;  1NCC N;  1Z50 A;  4YW3 A;  3TIA A;  4GJT A;  1V0F A;  4KS5 A;  4FPY A;  1N1Y A;  2W5O A;  1NCD N;  1WCS A;  2XCY A;  4MX0 A;  4MJV A;  4XJW A;  1KIT A;  2X9M A;  2W8B B;  1W0P A;  1W8O A;  1IVD A;  4XHX A;  2YDT A;  1NSB A;  3H73 A;  4YZ5 A;  1B9V A;  2HU0 A;  2HTY A;  2VSM A;  3KYA A;  4XJA A;  1K32 A;  2QWB A;  3O9J A;  4HW6 A;  4MWQ A;  1E8U A;  4GDI A;  3W09 A;  2OJH A;  3SIL A;  2DSO A;  4KS4 A;  1C5K A;  4XYX A;  1L7G A;  1SLL A;  3O9K A;  4Q6K A;  1SUU A;  2HTU A;  3LI4 A;  3II7 A;  4CPN A;  1A4G A;  2HTQ A;  1W1X A;  2FP9 A;  3CL2 A;  5CGJ A;  2QWG A;  1CRZ A;  2HTW A;  1B9S A;  3SOB B;  4GN9 A;  3BEQ A;  4CPZ A;  2QWH A;  4XJ9 A;  1SO7 A;  4HZW A;  2IAV A;  4HZZ A;  1A4Q A;  4KS3 A;  3K37 A;  3KGG A;  2IAT A;  1NSC A;  3A72 A;  4GZS A;  2F13 A;  4FPG A;  4N1B A;  2YDP A;  1L7H A;  4MWU A;  3IAX A;  4XJQ A;  1NMB N;  5HUM A;  1NSD A;  3LI5 A;  3AMR A;  4X47 A;  1CQ1 A;  3Q6T A;  4FOQ A;  4XE9 A;  2W38 A;  2QWD A;  1XOE A;  1W0O A;  1NN2 A;  3A9H A;  4XMA A;  5GX3 A;  3K36 A;  3SAL A;  1ZI0 A;  1W20 A;  1DIM A;  1ZGK A;  3HLH A;  4M3M A;  1INH A;  3NO0 A;  1EUT A;  4ZY3 A;  3V65 B;  1L7F A;  4XMI A;  3H71 A;  2A75 A;  2VW0 A;  2VSK A;  1V3E A;  1F8B A;  1MS5 A;  4XOG A;  4XJR A;  5GX2 A;  4KS2 A;  5HUK A;  4GNB A;  5GX4 A;  2H2U A;  1CVM A;  1V3C A;  2YA4 A;  3PJQ A;  1EUU A;  1N1T A;  4L7B A;  2DG1 A;  2F12 A;  3SAN A;  5JYY A;  4FPC A;  4GNA A;  1NNA A;  3SLI A;  3GVK A;  2IAR A;  2XZK A;  2F24 A;  2VWD A;  4GZQ A;  2XZI A;  4SLI A;  4XIL A;  3ALX A;  4IFL X;  2IAQ A;  1MS3 A;  3U0S A;  4MC7 A;  1EUS A;  4HHQ A;  1V3B A;  3B69 A;  4GZW A;  4XJ8 A;  1BJI A;  2HTV A;  3G4H A;  1POO A;  1NPE A;  2GVX A;  1NNB A;  1NCA N;  2ZWA A;  1IVF A;  3HRP A;  1SLI A;  1VCU A;  4IFJ A;  5GX1 A;  3Q6P A;  4DGR A;  1CRU A;  2F27 A;  4D52 C;  4YZ2 A;  2VAQ A;  4GZO A;  4GNC A;  4YW4 A;  4B7J A;  3K38 A;  4FPJ A;  4X4A A;  1U6D X;  1S0I A;  4H53 A;  1N1V A;  4QNP A;  1IVE A;  2VK5 A;  4MWR A;  4D8S A;  1MS1 A;  3HLI A;  2JKB A;  4FJ6 A;  1F8C A;  1MZ5 A;  4MWJ A;  1Z4Y A;  3JU4 A;  1XOG A;  2HT8 A;  1C9U A;  4M4V A;  1H6L A;  2ISM A;  5FZN A;  3I1C A;  1V0E A;  4G3N A;  2YA7 A;  7NN9 A;  3G4E A;  3ZGD A;  2VW1 A;  4CPY A;  3T1E A;  3DAS A;  1NMC A;  2BER A;  1Z4W A;  3DR2 A;  4HZV A;  2FHR A;  2Z32 A;  4H52 A;  2GHS A;  4MJU A;  2AEQ A;  2ZB6 A;  2AGS A;  4NN9 A;  3H6J A;  1S1D A;  3VNH A;  4YW5 A;  2HTR A;  2HU4 A;  5FNS A;  2IAW A;  4WEF A;  4WA3 A;  5F9T A;  1IUB A;  2B8H A;  4FPL A;  2AEP A;  4FPE A;  2SIM A;  4YZ3 A;  1INV A;  2IAO A;  3S94 A; 
#chains in the Genus database with same CATH homology
 3ZGC A;  5FNU A;  3VNG A;  4L7D A;  1ZGK A;  4ZGC A;  4N1B A;  2Z32 A;  5F72 C;  5FNT A;  2FLU X;  4ZY3 A;  3II7 A;  3WN7 A;  4IFN X;  5FZJ A;  4CH9 A;  2ZWA A;  2ZZK A;  4IFJ A;  4YY8 A;  2WOZ A;  5FNQ A;  3VNH A;  2XN4 A;  4CHB A;  5CGJ A;  4IFL X;  4L7C A;  2DYH A;  5FNS A;  1X2J A;  3WDZ A;  5FZN A;  5FNR A;  4IQK A;  3ZGD A;  1U6D X;  4XMB A;  2ZW9 A;  4IN4 A;  4ASC A;  2VPJ A;  1X2R A;  4L7B A;  3ADE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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