3ADEA

Crystal structure of keap1 in complex with sequestosome-1/p62
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
289
structure length
289
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
pubmed doi rcsb
molecule tags Transcription
source organism Mus musculus
molecule keywords Kelch-like ECH-associated protein 1
total genus 63
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2010-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 3adeA00
3WN7A 4IFJA 5CGJA 2FLUX 4ASCA 3VNHA 5FNQA 2DYHA 2Z32A 2VPJA 4IFLX 4YY8A 1X2RA 5F72C 5FNSA 1X2JA 5FNTA 5FZNA 1U6DX 4ZGCA 4L7CA 4CHBA 1ZGKA 4N1BA 3ADEA 3VNGA 4XMBA 3ZGCA 2ZWAA 3WDZA 3ZGDA 4L7DA 2ZZKA 5FNRA 5FZJA 4CH9A 2WOZA 2XN4A 2ZW9A 4IFNX 3II7A 4ZY3A 5FNUA 4L7BA 4IQKA 4IN4A
chains in the Genus database with same CATH superfamily
1VCUA 4X49A 3IAXA 2SLIA 4YZ5A 3A9GA 1N6DA 1QBIA 4CSDA 1W1XA 4GZXA 2VAQA 4XHBA 4B7RA 4MWJA 1B9SA 4X47A 2QWIA 4QN3A 3Q6KA 3CKZA 4XJUA 4KS5A 2QE8A 4FPYA 5FNRA 3V64C 1S1DA 1MS5A 1V04A 1V0FA 4XOGA 4MWUA 4D8SA 1N1TA 2AH2A 2B8HA 3TI4A 1NMBN 2C4AA 2OJHA 5EO7A 1DIMA 3FW0A 2FPCA 2F12A 3GVKA 4FPCA 5FZNA 5D9BA 1WCSA 3VNGA 1N7DA 4QN5A 2GVUA 4GDJA 2QWCA 1N6EA 4KS4A 1IUCA 4MC7A 1IUBA 1INVA 4QNPA 2DG1A 4IN4A 4NC5A 4IYGA 4ASCA 4GZOA 3HRPA 4GN8A 3SALA 2YA7A 3TI6A 1F8BA 4D52C 3A72A 4SLIA 4WEFA 4GZPA 3BYCA 4XJ8A 1EUSA 4UF7A 5M1ZA 4GEZA 4HZWA 4XJQA 4MZEA 2YDPA 3HLIA 2H2UA 3D12A 3SOQA 3Q6PA 4XIKA 5EO8A 3K39A 5D9CA 1L7GA 2QWKA 2AGSA 2QWGA 3H71A 3O9KA 3LI3A 3LI4A 1S18A 1WP5A 1XOEA 1POOA 2SILA 1RWLA 3TI3A 4XJWA 2VPJA 1NPEA 5JYYA 4O5SA 4FPHA 1V0ZA 3P5BL 4R40A 3S94A 1NMCA 4B7NA 2QWFA 1Z50A 3W09A 1PJXA 1RWIA 3INBA 4GNCA 2RKCA 4GJTA 4GZWA 4KS1A 1MR5A 5EX7A 3ZGCA 1DILA 2HTUA 3TIAA 3TICA 3PJQA 4HHQA 2F24A 2VW2A 4B7MA 4XMIA 5GX1A 1CQ1A 2HQSA 3GVLA 3II7A 1INHA 1Z4ZA 4QN4A 4UOUA 2HTRA 2QWDA 1NCCN 1ZI0A 1MZ6A 1NCAN 1N1SA 5FNSA 4H52A 1MS3A 2VWDA 4MWVA 4K1IA 1KITA 3S8VA 1INGA 2XZIA 2YA4A 5NN9A 4MWQA 1VCJA 1W21A 4G3NA 3TC9A 2IAQA 2BZDA 4B7JA 1IJQA 3KYAA 4H53A 2HT8A 2IAOA 3JU4A 4FJ6A 5B2DA 1EUUA 4FZHA 1B9TA 4YW5A 4GZQA 1ZGKA 4D52B 3DR2A 4K1KA 2HU0A 4AHAA 4X6KA 1EUTA 5GX4A 4L7CA 2GVVA 3BEQA 1NSCA 2AEQA 1INFA 1MZ5A 1Z4WA 1W0OA 4WA3A 2F26A 2YA5A 2BERA 2QWAA 1W0PA 1V3EA 2GVWA 1IVFA 2W8BA 1A4QA 2YA6A 4J9TA 4ZLRA 2H2NA 4FPEA 3H6JA 5HUMA 4CPOA 4FOYA 4CHBA 4C1YB 5FWWA 1B9VA 1NCDN 3SOBB 3B69A 4FP2A 1SLIA 3OPZA 4FOVA 5CGJA 1MS9A 5F9TA 2G8SA 2BATA 4GZTA 2IAUA 1E8UA 2VW0A 2GHSA 1NNCA 2YDTA 5HUKA 2FHRA 4FPLA 5HX0A 4HZYA 1NNBA 2IAXA 3SREA 1OFZA 3V1SA 4MWRA 4XMBA 4YW4A 4XIOA 1MS1A 1USXA 3NSSA 1SNTA 2WOZA 1IVBA 4IFNX 2BF6A 4FQ4A 3K37A 4FPJA 3UC1A 3SOVA 3LI5A 3ALXA 2DYHA 2F11A 2HTYA 3O9JA 2HU4A 2YA8A 4X4AA 3SRGA 1SLLA 1X2JA 4QN7A 4Q1UA 5D9DA 4JMLA 4ZGCA 1S0JA 4FOWA 2CMLA 3ADEA 4MWLA 1W8NA 4HZZA 4YZ2A 4YZ1A 3S2KA 2XZKA 2DSOA 2GVXA 1L7FA 1Q7FA 2IAWA 2F25A 1E1AA 2XZJA 4FVKA 2FP8A 2HT7A 5FNQA 3SILA 4AH4A 2V91A 4GN7A 1NSBA 2IARA 4XILA 4YW1A 1H6LA 3CL2A 4A0PA 3DASA 4M4VA 1V2IA 2F10A 3V65B 1N1YA 4CPYA 3Q6TA 4XMAA 4NCSA 1INWA 4GNBA 4CPMA 2F0ZA 1NMAN 3L6VA 4C1YA 5FNUA 1WCQA 3ALWA 3TI8A 2IATA 4IFJA 3WN7A 4DGRA 3NO0A 4XHXA 3A71A 1EURA 1F8EA 3FVZA 4XE9A 5FNTA 1A4GA 1F8DA 2JKBA 1E8TA 4CPNA 4FPKA 4XJZA 2HT5A 1U6DX 6NN9A 1USRA 5HUNA 1E8VA 4K1JA 4N1BA 4MJVA 3AMSA 4KS3A 2ZZKA 1NNAA 1W8OA 3GVJA 4CH9A 3TIBA 5H47A 1L7HA 2ZB5A 1W20A 1XOGA 4M4UA 1V3CA 2XCYA 3TI5A 2AEPA 1S0IA 2ZB6A 2W5OA 4FPGA 3CL0A 4YW3A 4CPZA 2HTWA 5GX2A 4FPOB 5FZJA 4GN9A 3WW9A 2SIMA 3I1CA 2POOA 3AMRA 4O5TA 5GX3A 1K32A 4WA4A 4HZXA 1X2RA 1Z4VA 2W5NA 4K1HA 4M4NA 1N1VA 3T1EA 4BBWA 3K3AA 3U0SA 4WA5A 3SLIA 4MJUA 4Q6KA 1MWEA 4AGIA 4FOQA 1N6FA 4WEGA 1NSDA 4GNAA 5GTQA 1Z4YA 2F28A 2VK6A 4AGTA 2IAVA 2QWBA 1V3BA 4ZY3A 3S8ZA 4XJ9A 4IQKA 1MS8A 3K36A 3O4PA 1V0EA 7NN9A 2VSMA 4QN6A 4NN9A 1C9UA 2IVZA 1MS0A 2VW1A 4HZVA 2VK7A 4MWWA 2VK5A 4XJRA 3HLHA 3G4HA 2C4LA 4KS2A 3WWAA 4XYXA 1CRUA 4L7DA 3SANA 4IMBA 3KGGA 4K3YA 3H73A 3D11A 1INXA 2A75A 2QWHA 4FP3A 4GDIA 2XN4A 4YW2A 1IVEA 4L7BA 3K38A 2ISMA 2W8BB 4M3MA 4D52A 2F13A 4MWYA 4MX0A 4HHOA 2DG0A 2FLUX 3E5ZA 1CVMA 1SUUA 2Z32A 4FPFA 4HW6A 3NN9A 4IFLX 2HTQA 3A9HA 2VVZA 4CPLA 1SO7A 1V3DA 1IVDA 4HIZA 2FPBA 2QWJA 2W38A 5GX5A 4JF7A 1NN2A 3G4EA 3WDZA 3CYEA 1MS4A 2F29A 4YZ4A 1IVCA 1QLGA 4D4UA 4MZAA 4GB1A 4PWZA 2W20A 4DG6A 1BJIA 2P4OA 2IAPA 2F27A 3H72A 2HTVA 3VNHA 4XJAA 1A14N 4GZSA 2VSKA 1CRZA 1C5KA 5F72C 2X9MA 1NCBN 1Z4XA 1F8CA 1IVGA 4YZ3A 1INYA 2FP9A 3B7EA 5B2CA 2QWEA 2ZWAA 4I00A 4MWXA 2IASA 3ZGDA 4B7QA 5HUGA 2ZW9A 4YY8A
chains in the Genus database with same CATH topology
3WN7A 4IFJA 5CGJA 2FLUX 4ASCA 3VNHA 5FNQA 2DYHA 2Z32A 2VPJA 4IFLX 4YY8A 1X2RA 5F72C 5FNSA 1X2JA 5FNTA 5FZNA 1U6DX 4ZGCA 4L7CA 4CHBA 1ZGKA 4N1BA 3ADEA 3VNGA 4XMBA 3ZGCA 2ZWAA 3WDZA 3ZGDA 4L7DA 2ZZKA 5FNRA 5FZJA 4CH9A 2WOZA 2XN4A 2ZW9A 4IFNX 3II7A 4ZY3A 5FNUA 4L7BA 4IQKA 4IN4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WN7 A;  4IFJ A;  5CGJ A;  2FLU X;  4ASC A;  3VNH A;  5FNQ A;  2DYH A;  2Z32 A;  2VPJ A;  4IFL X;  4YY8 A;  1X2R A;  5F72 C;  5FNS A;  1X2J A;  5FNT A;  5FZN A;  1U6D X;  4ZGC A;  4L7C A;  4CHB A;  1ZGK A;  4N1B A;  3ADE A;  3VNG A;  4XMB A;  3ZGC A;  2ZWA A;  3WDZ A;  3ZGD A;  4L7D A;  2ZZK A;  5FNR A;  5FZJ A;  4CH9 A;  2WOZ A;  2XN4 A;  2ZW9 A;  4IFN X;  3II7 A;  4ZY3 A;  5FNU A;  4L7B A;  4IQK A;  4IN4 A; 
#chains in the Genus database with same CATH topology
 1VCU A;  4X49 A;  3IAX A;  2SLI A;  4YZ5 A;  3A9G A;  1N6D A;  1QBI A;  4CSD A;  1W1X A;  4GZX A;  2VAQ A;  4XHB A;  4B7R A;  4MWJ A;  1B9S A;  4X47 A;  2QWI A;  4QN3 A;  3Q6K A;  3CKZ A;  4XJU A;  4KS5 A;  2QE8 A;  4FPY A;  5FNR A;  3V64 C;  1S1D A;  1MS5 A;  1V04 A;  1V0F A;  4XOG A;  4MWU A;  4D8S A;  1N1T A;  2AH2 A;  2B8H A;  3TI4 A;  1NMB N;  2C4A A;  2OJH A;  5EO7 A;  1DIM A;  3FW0 A;  2FPC A;  2F12 A;  3GVK A;  4FPC A;  5FZN A;  5D9B A;  1WCS A;  3VNG A;  1N7D A;  4QN5 A;  2GVU A;  4GDJ A;  2QWC A;  1N6E A;  4KS4 A;  1IUC A;  4MC7 A;  1IUB A;  1INV A;  4QNP A;  2DG1 A;  4IN4 A;  4NC5 A;  4IYG A;  4ASC A;  4GZO A;  3HRP A;  4GN8 A;  3SAL A;  2YA7 A;  3TI6 A;  1F8B A;  4D52 C;  3A72 A;  4SLI A;  4WEF A;  4GZP A;  3BYC A;  4XJ8 A;  1EUS A;  4UF7 A;  5M1Z A;  4GEZ A;  4HZW A;  4XJQ A;  4MZE A;  2YDP A;  3HLI A;  2H2U A;  3D12 A;  3SOQ A;  3Q6P A;  4XIK A;  5EO8 A;  3K39 A;  5D9C A;  1L7G A;  2QWK A;  2AGS A;  2QWG A;  3H71 A;  3O9K A;  3LI3 A;  3LI4 A;  1S18 A;  1WP5 A;  1XOE A;  1POO A;  2SIL A;  1RWL A;  3TI3 A;  4XJW A;  2VPJ A;  1NPE A;  5JYY A;  4O5S A;  4FPH A;  1V0Z A;  3P5B L;  4R40 A;  3S94 A;  1NMC A;  4B7N A;  2QWF A;  1Z50 A;  3W09 A;  1PJX A;  1RWI A;  3INB A;  4GNC A;  2RKC A;  4GJT A;  4GZW A;  4KS1 A;  1MR5 A;  5EX7 A;  3ZGC A;  1DIL A;  2HTU A;  3TIA A;  3TIC A;  3PJQ A;  4HHQ A;  2F24 A;  2VW2 A;  4B7M A;  4XMI A;  5GX1 A;  1CQ1 A;  2HQS A;  3GVL A;  3II7 A;  1INH A;  1Z4Z A;  4QN4 A;  4UOU A;  2HTR A;  2QWD A;  1NCC N;  1ZI0 A;  1MZ6 A;  1NCA N;  1N1S A;  5FNS A;  4H52 A;  1MS3 A;  2VWD A;  4MWV A;  4K1I A;  1KIT A;  3S8V A;  1ING A;  2XZI A;  2YA4 A;  5NN9 A;  4MWQ A;  1VCJ A;  1W21 A;  4G3N A;  3TC9 A;  2IAQ A;  2BZD A;  4B7J A;  1IJQ A;  3KYA A;  4H53 A;  2HT8 A;  2IAO A;  3JU4 A;  4FJ6 A;  5B2D A;  1EUU A;  4FZH A;  1B9T A;  4YW5 A;  4GZQ A;  1ZGK A;  4D52 B;  3DR2 A;  4K1K A;  2HU0 A;  4AHA A;  4X6K A;  1EUT A;  5GX4 A;  4L7C A;  2GVV A;  3BEQ A;  1NSC A;  2AEQ A;  1INF A;  1MZ5 A;  1Z4W A;  1W0O A;  4WA3 A;  2F26 A;  2YA5 A;  2BER A;  2QWA A;  1W0P A;  1V3E A;  2GVW A;  1IVF A;  2W8B A;  1A4Q A;  2YA6 A;  4J9T A;  4ZLR A;  2H2N A;  4FPE A;  3H6J A;  5HUM A;  4CPO A;  4FOY A;  4CHB A;  4C1Y B;  5FWW A;  1B9V A;  1NCD N;  3SOB B;  3B69 A;  4FP2 A;  1SLI A;  3OPZ A;  4FOV A;  5CGJ A;  1MS9 A;  5F9T A;  2G8S A;  2BAT A;  4GZT A;  2IAU A;  1E8U A;  2VW0 A;  2GHS A;  1NNC A;  2YDT A;  5HUK A;  2FHR A;  4FPL A;  5HX0 A;  4HZY A;  1NNB A;  2IAX A;  3SRE A;  1OFZ A;  3V1S A;  4MWR A;  4XMB A;  4YW4 A;  4XIO A;  1MS1 A;  1USX A;  3NSS A;  1SNT A;  2WOZ A;  1IVB A;  4IFN X;  2BF6 A;  4FQ4 A;  3K37 A;  4FPJ A;  3UC1 A;  3SOV A;  3LI5 A;  3ALX A;  2DYH A;  2F11 A;  2HTY A;  3O9J A;  2HU4 A;  2YA8 A;  4X4A A;  3SRG A;  1SLL A;  1X2J A;  4QN7 A;  4Q1U A;  5D9D A;  4JML A;  4ZGC A;  1S0J A;  4FOW A;  2CML A;  3ADE A;  4MWL A;  1W8N A;  4HZZ A;  4YZ2 A;  4YZ1 A;  3S2K A;  2XZK A;  2DSO A;  2GVX A;  1L7F A;  1Q7F A;  2IAW A;  2F25 A;  1E1A A;  2XZJ A;  4FVK A;  2FP8 A;  2HT7 A;  5FNQ A;  3SIL A;  4AH4 A;  2V91 A;  4GN7 A;  1NSB A;  2IAR A;  4XIL A;  4YW1 A;  1H6L A;  3CL2 A;  4A0P A;  3DAS A;  4M4V A;  1V2I A;  2F10 A;  3V65 B;  1N1Y A;  4CPY A;  3Q6T A;  4XMA A;  4NCS A;  1INW A;  4GNB A;  4CPM A;  2F0Z A;  1NMA N;  3L6V A;  4C1Y A;  5FNU A;  1WCQ A;  3ALW A;  3TI8 A;  2IAT A;  4IFJ A;  3WN7 A;  4DGR A;  3NO0 A;  4XHX A;  3A71 A;  1EUR A;  1F8E A;  3FVZ A;  4XE9 A;  5FNT A;  1A4G A;  1F8D A;  2JKB A;  1E8T A;  4CPN A;  4FPK A;  4XJZ A;  2HT5 A;  1U6D X;  6NN9 A;  1USR A;  5HUN A;  1E8V A;  4K1J A;  4N1B A;  4MJV A;  3AMS A;  4KS3 A;  2ZZK A;  1NNA A;  1W8O A;  3GVJ A;  4CH9 A;  3TIB A;  5H47 A;  1L7H A;  2ZB5 A;  1W20 A;  1XOG A;  4M4U A;  1V3C A;  2XCY A;  3TI5 A;  2AEP A;  1S0I A;  2ZB6 A;  2W5O A;  4FPG A;  3CL0 A;  4YW3 A;  4CPZ A;  2HTW A;  5GX2 A;  4FPO B;  5FZJ A;  4GN9 A;  3WW9 A;  2SIM A;  3I1C A;  2POO A;  3AMR A;  4O5T A;  5GX3 A;  1K32 A;  4WA4 A;  4HZX A;  1X2R A;  1Z4V A;  2W5N A;  4K1H A;  4M4N A;  1N1V A;  3T1E A;  4BBW A;  3K3A A;  3U0S A;  4WA5 A;  3SLI A;  4MJU A;  4Q6K A;  1MWE A;  4AGI A;  4FOQ A;  1N6F A;  4WEG A;  1NSD A;  4GNA A;  5GTQ A;  1Z4Y A;  2F28 A;  2VK6 A;  4AGT A;  2IAV A;  2QWB A;  1V3B A;  4ZY3 A;  3S8Z A;  4XJ9 A;  4IQK A;  1MS8 A;  3K36 A;  3O4P A;  1V0E A;  7NN9 A;  2VSM A;  4QN6 A;  4NN9 A;  1C9U A;  2IVZ A;  1MS0 A;  2VW1 A;  4HZV A;  2VK7 A;  4MWW A;  2VK5 A;  4XJR A;  3HLH A;  3G4H A;  2C4L A;  4KS2 A;  3WWA A;  4XYX A;  1CRU A;  4L7D A;  3SAN A;  4IMB A;  3KGG A;  4K3Y A;  3H73 A;  3D11 A;  1INX A;  2A75 A;  2QWH A;  4FP3 A;  4GDI A;  2XN4 A;  4YW2 A;  1IVE A;  4L7B A;  3K38 A;  2ISM A;  2W8B B;  4M3M A;  4D52 A;  2F13 A;  4MWY A;  4MX0 A;  4HHO A;  2DG0 A;  2FLU X;  3E5Z A;  1CVM A;  1SUU A;  2Z32 A;  4FPF A;  4HW6 A;  3NN9 A;  4IFL X;  2HTQ A;  3A9H A;  2VVZ A;  4CPL A;  1SO7 A;  1V3D A;  1IVD A;  4HIZ A;  2FPB A;  2QWJ A;  2W38 A;  5GX5 A;  4JF7 A;  1NN2 A;  3G4E A;  3WDZ A;  3CYE A;  1MS4 A;  2F29 A;  4YZ4 A;  1IVC A;  1QLG A;  4D4U A;  4MZA A;  4GB1 A;  4PWZ A;  2W20 A;  4DG6 A;  1BJI A;  2P4O A;  2IAP A;  2F27 A;  3H72 A;  2HTV A;  3VNH A;  4XJA A;  1A14 N;  4GZS A;  2VSK A;  1CRZ A;  1C5K A;  5F72 C;  2X9M A;  1NCB N;  1Z4X A;  1F8C A;  1IVG A;  4YZ3 A;  1INY A;  2FP9 A;  3B7E A;  5B2C A;  2QWE A;  2ZWA A;  4I00 A;  4MWX A;  2IAS A;  3ZGD A;  4B7Q A;  5HUG A;  2ZW9 A;  4YY8 A; 
#chains in the Genus database with same CATH homology
 3WN7 A;  4IFJ A;  5CGJ A;  2FLU X;  4ASC A;  3VNH A;  5FNQ A;  2DYH A;  2Z32 A;  2VPJ A;  4IFL X;  4YY8 A;  1X2R A;  5F72 C;  5FNS A;  1X2J A;  5FNT A;  5FZN A;  1U6D X;  4ZGC A;  4L7C A;  4CHB A;  1ZGK A;  4N1B A;  3ADE A;  3VNG A;  4XMB A;  3ZGC A;  2ZWA A;  3WDZ A;  3ZGD A;  4L7D A;  2ZZK A;  5FNR A;  5FZJ A;  4CH9 A;  2WOZ A;  2XN4 A;  2ZW9 A;  4IFN X;  3II7 A;  4ZY3 A;  5FNU A;  4L7B A;  4IQK A;  4IN4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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