4L7CA

Structure of keap1 kelch domain with 2-{[(1s)-2-{[(1r,2s)-2-(1h-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1h-isoindole-1,3(2h)-dione
Total Genus 63

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
286
structure length
286
Chain Sequence
RLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTLE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription/inhibitor
source organism Homo sapiens
publication title Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
pubmed doi rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 63
structure length 286
sequence length 286
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2013-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4l7cA00
3ZGDA 1ZGKA 2ZW9A 1X2JA 5F72C 4XMBA 2ZWAA 4IFJA 2VPJA 4IQKA 3WDZA 1U6DX 2FLUX 5FZJA 5FNSA 4L7BA 5CGJA 4ASCA 3VNGA 2Z32A 1X2RA 5FZNA 4YY8A 4IN4A 4IFNX 4ZGCA 5FNRA 4IFLX 3ADEA 5FNTA 3ZGCA 4CHBA 5FNQA 2ZZKA 4L7DA 3II7A 3VNHA 2DYHA 3WN7A 4ZY3A 4N1BA 5FNUA 2WOZA 2XN4A 4L7CA 4CH9A
chains in the Genus database with same CATH superfamily
1INHA 1Z4ZA 1MZ5A 1NNBA 1ZGKA 4UF7A 5FWWA 2FHRA 2RKCA 2YA8A 1B9SA 1CRUA 4HHQA 1MR5A 1DIMA 2Z32A 3TIAA 2DG1A 1B9TA 1C5KA 2V91A 4FPFA 3I1CA 4FP2A 4FPJA 3LI4A 5HUMA 4CSDA 3GVJA 4M4NA 2CMLA 2QWJA 2G8SA 2ZZKA 1N6FA 4FPOB 3BEQA 1N1VA 2XN4A 3P5BL 1W20A 4XJWA 4GZOA 2H2NA 4FPKA 5JYYA 4FOWA 4XOGA 3GVKA 3S8VA 1INFA 2F12A 1S18A 1NMBN 1CRZA 2HQSA 1NCDN 2FPCA 3CL2A 4KS2A 3CKZA 3TI3A 4X6KA 1SLLA 4G3NA 4IFNX 3ADEA 1RWLA 3K37A 4QN7A 4XJRA 7NN9A 1RWIA 3CL0A 1S1DA 3D12A 3OPZA 4XMBA 5GTQA 2SILA 4DGRA 1IUCA 1NSDA 3B7EA 3K38A 4M3MA 4MWWA 2QWBA 5HUNA 3E5ZA 3A71A 2XZKA 4HZXA 1EURA 3H71A 1Z4VA 4JF7A 2XZIA 4PWZA 3TI5A 1MS3A 4XE9A 3ZGCA 2HTWA 5FNQA 4D52C 4XHBA 4UOUA 2A75A 4FP3A 2IAVA 1VCJA 4N1BA 2HTRA 4FJ6A 1EUTA 2B8HA 2W5OA 2XCYA 1NSBA 1MS1A 1USRA 4GNCA 2HT8A 4HIZA 1PJXA 4MWXA 1L7FA 1INYA 2HU0A 3TC9A 4MWLA 2HTVA 4YW2A 2ISMA 4CPOA 1XOEA 2AEQA 1MZ6A 2SLIA 3K36A 4ZGCA 3T1EA 3A72A 2F24A 2ZB6A 3SANA 4CPLA 4XJ8A 4XHXA 4A0PA 3HLIA 4ZY3A 2YDPA 2WOZA 4O5SA 4H52A 2ZB5A 4M4UA 3B69A 2W5NA 4HZVA 4YZ2A 4FPCA 3FVZA 1XOGA 1K32A 3SOQA 1V3EA 4GNAA 2QWIA 1F8BA 2VK5A 3JU4A 1W0PA 2H2UA 2X9MA 4FPEA 4FPGA 2XZJA 4YW4A 3HLHA 2W20A 4MWYA 1IJQA 4GN7A 4KS4A 1SO7A 4D8SA 1W8OA 1WP5A 1X2JA 1A4QA 5F72C 1N1TA 3K39A 4IFJA 1N6DA 3SOVA 4AH4A 4ASCA 4X49A 4FQ4A 2HTQA 4NN9A 1B9VA 4K1HA 2SIMA 4MZEA 4K1JA 1QLGA 2HU4A 2IAQA 2QWHA 2W8BA 4NCSA 2BZDA 1L7HA 1QBIA 4GZQA 2W8BB 3INBA 4MWQA 3V65B 3PJQA 5EO8A 3H72A 1MS9A 4XJZA 3AMSA 2IAOA 4X4AA 2VVZA 2QWAA 2QWCA 1V3DA 1BJIA 4MC7A 4M4VA 4QN5A 1IVGA 2QWEA 2JKBA 4FVKA 1H6LA 2F26A 4GNBA 2AEPA 4L7DA 4HW6A 2F0ZA 3TICA 3K3AA 1E1AA 1Z50A 2F27A 4MJVA 3A9HA 4XILA 1A4GA 3O4PA 2BERA 3BYCA 3Q6KA 2QWFA 2YDTA 2VK6A 1W8NA 5EO7A 4DG6A 5B2DA 4XJQA 1A14N 4XJAA 4MX0A 1X2RA 1MWEA 4YY8A 3U0SA 1V0EA 2HTYA 3V64C 1SUUA 1F8EA 4H53A 4FPHA 1Z4YA 4IN4A 5GX1A 1DILA 4J9TA 4HZYA 2C4AA 4HHOA 1NNAA 4GEZA 2BATA 1IVCA 3II7A 4GZSA 1EUUA 4FOVA 2F10A 1N1YA 1L7GA 1IUBA 5D9DA 2QWGA 4WA3A 4K1KA 5F9TA 1NN2A 4B7NA 1E8UA 1INGA 1N7DA 5GX4A 5HUKA 1NMCA 4YW1A 4XJ9A 1IVDA 5GX2A 1NPEA 1V2IA 3G4EA 3LI3A 3TI4A 5B2CA 2DYHA 3Q6TA 2FP9A 1Z4WA 4C1YA 2VAQA 2F13A 4MZAA 3G4HA 4IYGA 4KS5A 1NNCA 5FZJA 4YZ1A 3NN9A 4FOYA 4C1YB 1W1XA 3CYEA 5FZNA 4D4UA 1WCSA 4XJUA 1MS5A 1V3BA 4MWUA 2DSOA 4CHBA 3KYAA 1CVMA 4MJUA 2P4OA 4B7JA 1IVEA 4D52A 4YZ5A 1NCBN 1OFZA 2ZWAA 4D52B 1POOA 3KGGA 2VK7A 1MS4A 4CPYA 2OJHA 5HUGA 1C9UA 4B7QA 4XMIA 1USXA 4X47A 4FPLA 4XIOA 4AGTA 5NN9A 5FNRA 1W0OA 2VWDA 1EUSA 4GJTA 4GZWA 3LI5A 4YW3A 3WN7A 2YA6A 1F8CA 4KS3A 4B7RA 4KS1A 2YA5A 2F28A 3IAXA 4WA4A 3SRGA 3VNGA 5EX7A 2VW0A 3V1SA 4YZ4A 1S0IA 4QN6A 3HRPA 1INVA 3TI8A 1V0ZA 3Q6PA 1S0JA 2VSKA 1SLIA 1MS0A 4GDIA 2F11A 2GHSA 2VSMA 4HZZA 3S94A 1KITA 2HT7A 4MWJA 1VCUA 2QWDA 2GVUA 5D9CA 2HT5A 4WEGA 3DASA 4FZHA 2AGSA 4SLIA 1E8TA 1IVBA 3WDZA 4QN3A 5H47A 2IAUA 1IVFA 4WEFA 1NCAN 3AMRA 2F29A 1N6EA 3FW0A 4JMLA 1MS8A 5M1ZA 3GVLA 4GZTA 3O9JA 2QWKA 4GN8A 4MWRA 3W09A 4YW5A 3S2KA 3ALXA 2GVWA 2YA7A 2IATA 2ZW9A 4XMAA 1CQ1A 2IAXA 1V0FA 3S8ZA 1ZI0A 4YZ3A 4K1IA 1NCCN 2VPJA 2POOA 2FLUX 3TIBA 4FOQA 4O5TA 4L7BA 5FNSA 5CGJA 4ZLRA 1Q7FA 4GDJA 2YA4A 4XIKA 2IARA 1E8VA 3ALWA 4GZPA 3WW9A 4GZXA 3L6VA 2VW1A 3WWAA 4HZWA 4IMBA 4R40A 2FP8A 3DR2A 3VNHA 2GVVA 5FNUA 4L7CA 4I00A 2AH2A 3NSSA 5D9BA 1WCQA 4BBWA 2DG0A 4IQKA 3SALA 1U6DX 2GVXA 4CPNA 3O9KA 4GB1A 4Q6KA 3UC1A 4FPYA 2IAPA 4QN4A 4QNPA 3D11A 4Q1UA 3SREA 1INXA 1F8DA 1NSCA 3H73A 1INWA 2IVZA 4CH9A 1Z4XA 4AHAA 3TI6A 3ZGDA 6NN9A 4B7MA 1V04A 4XYXA 4AGIA 3A9GA 5GX5A 3H6JA 2BF6A 2IAWA 2IASA 2FPBA 4MWVA 2W38A 2VW2A 1N1SA 3SOBB 4CPZA 5HX0A 1NMAN 2F25A 4CPMA 2C4LA 3NO0A 3SILA 4NC5A 4IFLX 3SLIA 1SNTA 1V3CA 5FNTA 2HTUA 5GX3A 2QE8A 4WA5A 4K3YA 1W21A 4GN9A
chains in the Genus database with same CATH topology
3ZGDA 1ZGKA 2ZW9A 1X2JA 5F72C 4XMBA 2ZWAA 4IFJA 2VPJA 4IQKA 3WDZA 1U6DX 2FLUX 5FZJA 5FNSA 4L7BA 5CGJA 4ASCA 3VNGA 2Z32A 1X2RA 5FZNA 4YY8A 4IN4A 4IFNX 4ZGCA 5FNRA 4IFLX 3ADEA 5FNTA 3ZGCA 4CHBA 5FNQA 2ZZKA 4L7DA 3II7A 3VNHA 2DYHA 3WN7A 4ZY3A 4N1BA 5FNUA 2WOZA 2XN4A 4L7CA 4CH9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZGD A;  1ZGK A;  2ZW9 A;  1X2J A;  5F72 C;  4XMB A;  2ZWA A;  4IFJ A;  2VPJ A;  4IQK A;  3WDZ A;  1U6D X;  2FLU X;  5FZJ A;  5FNS A;  4L7B A;  5CGJ A;  4ASC A;  3VNG A;  2Z32 A;  1X2R A;  5FZN A;  4YY8 A;  4IN4 A;  4IFN X;  4ZGC A;  5FNR A;  4IFL X;  3ADE A;  5FNT A;  3ZGC A;  4CHB A;  5FNQ A;  2ZZK A;  4L7D A;  3II7 A;  3VNH A;  2DYH A;  3WN7 A;  4ZY3 A;  4N1B A;  5FNU A;  2WOZ A;  2XN4 A;  4L7C A;  4CH9 A; 
#chains in the Genus database with same CATH topology
 1INH A;  1Z4Z A;  1MZ5 A;  1NNB A;  1ZGK A;  4UF7 A;  5FWW A;  2FHR A;  2RKC A;  2YA8 A;  1B9S A;  1CRU A;  4HHQ A;  1MR5 A;  1DIM A;  2Z32 A;  3TIA A;  2DG1 A;  1B9T A;  1C5K A;  2V91 A;  4FPF A;  3I1C A;  4FP2 A;  4FPJ A;  3LI4 A;  5HUM A;  4CSD A;  3GVJ A;  4M4N A;  2CML A;  2QWJ A;  2G8S A;  2ZZK A;  1N6F A;  4FPO B;  3BEQ A;  1N1V A;  2XN4 A;  3P5B L;  1W20 A;  4XJW A;  4GZO A;  2H2N A;  4FPK A;  5JYY A;  4FOW A;  4XOG A;  3GVK A;  3S8V A;  1INF A;  2F12 A;  1S18 A;  1NMB N;  1CRZ A;  2HQS A;  1NCD N;  2FPC A;  3CL2 A;  4KS2 A;  3CKZ A;  3TI3 A;  4X6K A;  1SLL A;  4G3N A;  4IFN X;  3ADE A;  1RWL A;  3K37 A;  4QN7 A;  4XJR A;  7NN9 A;  1RWI A;  3CL0 A;  1S1D A;  3D12 A;  3OPZ A;  4XMB A;  5GTQ A;  2SIL A;  4DGR A;  1IUC A;  1NSD A;  3B7E A;  3K38 A;  4M3M A;  4MWW A;  2QWB A;  5HUN A;  3E5Z A;  3A71 A;  2XZK A;  4HZX A;  1EUR A;  3H71 A;  1Z4V A;  4JF7 A;  2XZI A;  4PWZ A;  3TI5 A;  1MS3 A;  4XE9 A;  3ZGC A;  2HTW A;  5FNQ A;  4D52 C;  4XHB A;  4UOU A;  2A75 A;  4FP3 A;  2IAV A;  1VCJ A;  4N1B A;  2HTR A;  4FJ6 A;  1EUT A;  2B8H A;  2W5O A;  2XCY A;  1NSB A;  1MS1 A;  1USR A;  4GNC A;  2HT8 A;  4HIZ A;  1PJX A;  4MWX A;  1L7F A;  1INY A;  2HU0 A;  3TC9 A;  4MWL A;  2HTV A;  4YW2 A;  2ISM A;  4CPO A;  1XOE A;  2AEQ A;  1MZ6 A;  2SLI A;  3K36 A;  4ZGC A;  3T1E A;  3A72 A;  2F24 A;  2ZB6 A;  3SAN A;  4CPL A;  4XJ8 A;  4XHX A;  4A0P A;  3HLI A;  4ZY3 A;  2YDP A;  2WOZ A;  4O5S A;  4H52 A;  2ZB5 A;  4M4U A;  3B69 A;  2W5N A;  4HZV A;  4YZ2 A;  4FPC A;  3FVZ A;  1XOG A;  1K32 A;  3SOQ A;  1V3E A;  4GNA A;  2QWI A;  1F8B A;  2VK5 A;  3JU4 A;  1W0P A;  2H2U A;  2X9M A;  4FPE A;  4FPG A;  2XZJ A;  4YW4 A;  3HLH A;  2W20 A;  4MWY A;  1IJQ A;  4GN7 A;  4KS4 A;  1SO7 A;  4D8S A;  1W8O A;  1WP5 A;  1X2J A;  1A4Q A;  5F72 C;  1N1T A;  3K39 A;  4IFJ A;  1N6D A;  3SOV A;  4AH4 A;  4ASC A;  4X49 A;  4FQ4 A;  2HTQ A;  4NN9 A;  1B9V A;  4K1H A;  2SIM A;  4MZE A;  4K1J A;  1QLG A;  2HU4 A;  2IAQ A;  2QWH A;  2W8B A;  4NCS A;  2BZD A;  1L7H A;  1QBI A;  4GZQ A;  2W8B B;  3INB A;  4MWQ A;  3V65 B;  3PJQ A;  5EO8 A;  3H72 A;  1MS9 A;  4XJZ A;  3AMS A;  2IAO A;  4X4A A;  2VVZ A;  2QWA A;  2QWC A;  1V3D A;  1BJI A;  4MC7 A;  4M4V A;  4QN5 A;  1IVG A;  2QWE A;  2JKB A;  4FVK A;  1H6L A;  2F26 A;  4GNB A;  2AEP A;  4L7D A;  4HW6 A;  2F0Z A;  3TIC A;  3K3A A;  1E1A A;  1Z50 A;  2F27 A;  4MJV A;  3A9H A;  4XIL A;  1A4G A;  3O4P A;  2BER A;  3BYC A;  3Q6K A;  2QWF A;  2YDT A;  2VK6 A;  1W8N A;  5EO7 A;  4DG6 A;  5B2D A;  4XJQ A;  1A14 N;  4XJA A;  4MX0 A;  1X2R A;  1MWE A;  4YY8 A;  3U0S A;  1V0E A;  2HTY A;  3V64 C;  1SUU A;  1F8E A;  4H53 A;  4FPH A;  1Z4Y A;  4IN4 A;  5GX1 A;  1DIL A;  4J9T A;  4HZY A;  2C4A A;  4HHO A;  1NNA A;  4GEZ A;  2BAT A;  1IVC A;  3II7 A;  4GZS A;  1EUU A;  4FOV A;  2F10 A;  1N1Y A;  1L7G A;  1IUB A;  5D9D A;  2QWG A;  4WA3 A;  4K1K A;  5F9T A;  1NN2 A;  4B7N A;  1E8U A;  1ING A;  1N7D A;  5GX4 A;  5HUK A;  1NMC A;  4YW1 A;  4XJ9 A;  1IVD A;  5GX2 A;  1NPE A;  1V2I A;  3G4E A;  3LI3 A;  3TI4 A;  5B2C A;  2DYH A;  3Q6T A;  2FP9 A;  1Z4W A;  4C1Y A;  2VAQ A;  2F13 A;  4MZA A;  3G4H A;  4IYG A;  4KS5 A;  1NNC A;  5FZJ A;  4YZ1 A;  3NN9 A;  4FOY A;  4C1Y B;  1W1X A;  3CYE A;  5FZN A;  4D4U A;  1WCS A;  4XJU A;  1MS5 A;  1V3B A;  4MWU A;  2DSO A;  4CHB A;  3KYA A;  1CVM A;  4MJU A;  2P4O A;  4B7J A;  1IVE A;  4D52 A;  4YZ5 A;  1NCB N;  1OFZ A;  2ZWA A;  4D52 B;  1POO A;  3KGG A;  2VK7 A;  1MS4 A;  4CPY A;  2OJH A;  5HUG A;  1C9U A;  4B7Q A;  4XMI A;  1USX A;  4X47 A;  4FPL A;  4XIO A;  4AGT A;  5NN9 A;  5FNR A;  1W0O A;  2VWD A;  1EUS A;  4GJT A;  4GZW A;  3LI5 A;  4YW3 A;  3WN7 A;  2YA6 A;  1F8C A;  4KS3 A;  4B7R A;  4KS1 A;  2YA5 A;  2F28 A;  3IAX A;  4WA4 A;  3SRG A;  3VNG A;  5EX7 A;  2VW0 A;  3V1S A;  4YZ4 A;  1S0I A;  4QN6 A;  3HRP A;  1INV A;  3TI8 A;  1V0Z A;  3Q6P A;  1S0J A;  2VSK A;  1SLI A;  1MS0 A;  4GDI A;  2F11 A;  2GHS A;  2VSM A;  4HZZ A;  3S94 A;  1KIT A;  2HT7 A;  4MWJ A;  1VCU A;  2QWD A;  2GVU A;  5D9C A;  2HT5 A;  4WEG A;  3DAS A;  4FZH A;  2AGS A;  4SLI A;  1E8T A;  1IVB A;  3WDZ A;  4QN3 A;  5H47 A;  2IAU A;  1IVF A;  4WEF A;  1NCA N;  3AMR A;  2F29 A;  1N6E A;  3FW0 A;  4JML A;  1MS8 A;  5M1Z A;  3GVL A;  4GZT A;  3O9J A;  2QWK A;  4GN8 A;  4MWR A;  3W09 A;  4YW5 A;  3S2K A;  3ALX A;  2GVW A;  2YA7 A;  2IAT A;  2ZW9 A;  4XMA A;  1CQ1 A;  2IAX A;  1V0F A;  3S8Z A;  1ZI0 A;  4YZ3 A;  4K1I A;  1NCC N;  2VPJ A;  2POO A;  2FLU X;  3TIB A;  4FOQ A;  4O5T A;  4L7B A;  5FNS A;  5CGJ A;  4ZLR A;  1Q7F A;  4GDJ A;  2YA4 A;  4XIK A;  2IAR A;  1E8V A;  3ALW A;  4GZP A;  3WW9 A;  4GZX A;  3L6V A;  2VW1 A;  3WWA A;  4HZW A;  4IMB A;  4R40 A;  2FP8 A;  3DR2 A;  3VNH A;  2GVV A;  5FNU A;  4L7C A;  4I00 A;  2AH2 A;  3NSS A;  5D9B A;  1WCQ A;  4BBW A;  2DG0 A;  4IQK A;  3SAL A;  1U6D X;  2GVX A;  4CPN A;  3O9K A;  4GB1 A;  4Q6K A;  3UC1 A;  4FPY A;  2IAP A;  4QN4 A;  4QNP A;  3D11 A;  4Q1U A;  3SRE A;  1INX A;  1F8D A;  1NSC A;  3H73 A;  1INW A;  2IVZ A;  4CH9 A;  1Z4X A;  4AHA A;  3TI6 A;  3ZGD A;  6NN9 A;  4B7M A;  1V04 A;  4XYX A;  4AGI A;  3A9G A;  5GX5 A;  3H6J A;  2BF6 A;  2IAW A;  2IAS A;  2FPB A;  4MWV A;  2W38 A;  2VW2 A;  1N1S A;  3SOB B;  4CPZ A;  5HX0 A;  1NMA N;  2F25 A;  4CPM A;  2C4L A;  3NO0 A;  3SIL A;  4NC5 A;  4IFL X;  3SLI A;  1SNT A;  1V3C A;  5FNT A;  2HTU A;  5GX3 A;  2QE8 A;  4WA5 A;  4K3Y A;  1W21 A;  4GN9 A; 
#chains in the Genus database with same CATH homology
 3ZGD A;  1ZGK A;  2ZW9 A;  1X2J A;  5F72 C;  4XMB A;  2ZWA A;  4IFJ A;  2VPJ A;  4IQK A;  3WDZ A;  1U6D X;  2FLU X;  5FZJ A;  5FNS A;  4L7B A;  5CGJ A;  4ASC A;  3VNG A;  2Z32 A;  1X2R A;  5FZN A;  4YY8 A;  4IN4 A;  4IFN X;  4ZGC A;  5FNR A;  4IFL X;  3ADE A;  5FNT A;  3ZGC A;  4CHB A;  5FNQ A;  2ZZK A;  4L7D A;  3II7 A;  3VNH A;  2DYH A;  3WN7 A;  4ZY3 A;  4N1B A;  5FNU A;  2WOZ A;  2XN4 A;  4L7C A;  4CH9 A; 
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