4N1B | Genus

Total Genus 64

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	64
sequence length	286
structure length	286
Chain Sequence	RLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTLE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Transcription/inhibitor
source organism	Homo sapiens
publication title	Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. pubmed doi rcsb
molecule keywords	Kelch-like ECH-associated protein 1
total genus	64
structure length	286
sequence length	286
chains with identical sequence	B, C
ec nomenclature
pdb deposition date	2013-10-03

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01344	Kelch_1	Kelch motif

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	4n1bA00

4IFNX 5F72C 4IN4A 5FZNA 5FZJA 5CGJA 1ZGKA 2XN4A 3ZGDA 3ADEA 3ZGCA 2VPJA 4ZGCA 3VNHA 4CH9A 5FNSA 4IFJA 4CHBA 3II7A 2WOZA 2FLUX 4N1BA 1X2JA 3WDZA 3WN7A 4L7CA 2ZW9A 5FNQA 4YY8A 1U6DX 4L7BA 4ASCA 4IFLX 5FNTA 4ZY3A 4IQKA 2DYHA 4L7DA 4XMBA 1X2RA 2ZZKA 2Z32A 2ZWAA 3VNGA 5FNUA 5FNRA
chains in the Genus database with same CATH superfamily

2YA5A 2YA8A 4FP2A 4XHXA 1SLIA 4YW2A 1ZGKA 3ZGDA 1NSDA 3BEQA 4B7JA 2XZJA 3VNHA 1E8TA 2GVXA 1SO7A 4GNBA 1F8DA 3TC9A 4DG6A 4UOUA 4BBWA 4YZ4A 1N1SA 1INHA 1VCUA 2QWGA 4MWLA 4WA3A 2HTQA 1F8CA 5HUMA 2VK6A 3V65B 1X2RA 2QWIA 1INVA 2F0ZA 1CVMA 1W1XA 1IVEA 1NMBN 5EO7A 2QWDA 2F26A 4XHBA 2GVUA 1W8OA 4GZXA 2P4OA 2G8SA 2VAQA 5F9TA 3ALWA 4A0PA 4HZZA 1INYA 2IAWA 4L7BA 3NSSA 2QWCA 4FPCA 4CPZA 1MS0A 4GZSA 1SUUA 4D52A 4FPKA 4XJUA 1RWLA 4GNAA 2VWDA 4XIKA 5FNUA 2GVVA 2YDPA 4YZ3A 4WA5A 1E1AA 1IUCA 1N7DA 4H52A 1IVDA 3D12A 5M1ZA 1W20A 4FPOB 1W0PA 3WDZA 3WN7A 2ZB6A 5GTQA 3S94A 4MJVA 1A4QA 2HTYA 3L6VA 3LI5A 2BZDA 2XZKA 3V1SA 2ZWAA 1N6EA 2IVZA 4GJTA 2C4LA 2FPCA 1XOEA 4GNCA 3WWAA 5HUKA 2VPJA 4DGRA 3CKZA 3FW0A 4HIZA 4QN3A 2F25A 5FNSA 4FPYA 4HZVA 4AH4A 4GZTA 2F28A 4NN9A 4M4UA 1V3BA 3KGGA 4XJQA 4ASCA 1N1VA 2F24A 4M4VA 2FP8A 3SOBB 4X49A 1IVFA 2AEPA 3AMRA 3GVJA 4MWVA 3V64C 4IMBA 2F11A 4QN6A 3S2KA 5FWWA 1IUBA 3TI8A 3INBA 5F72C 5CGJA 3E5ZA 4Q1UA 4FPJA 4XOGA 3P5BL 3K36A 2QWAA 3II7A 1INXA 4N1BA 3SREA 4MWQA 4AHAA 3CL0A 2YA7A 1V3CA 4NC5A 4D8SA 1F8BA 4YY8A 2IAPA 4PWZA 4IFLX 1L7HA 4D52C 4GEZA 3Q6PA 2W5OA 4ZY3A 4ZLRA 4JMLA 2IATA 4XMAA 4FOWA 2JKBA 2ZB5A 3G4EA 2HQSA 3SOQA 1W0OA 4XE9A 1K32A 3K39A 1INGA 4ZGCA 4CSDA 4CH9A 4CPMA 3BYCA 2A75A 1NCCN 2WOZA 4MZEA 2YDTA 4YZ5A 1N6FA 2IASA 4IYGA 2AH2A 1N6DA 4GN7A 2YA6A 4MWJA 4FOYA 5B2DA 1NMAN 3KYAA 3S8VA 7NN9A 4MWUA 4MWXA 2W20A 2F12A 3VNGA 4K3YA 2QWKA 2W38A 5FZNA 3S8ZA 1B9TA 1E8VA 4MWWA 4K1KA 1Z4WA 6NN9A 2QWBA 3SRGA 2QWEA 2HT7A 1CRZA 1MS5A 2VK7A 3A71A 4FPEA 1E8UA 2QWFA 1N1YA 2QWJA 4B7MA 4H53A 3AMSA 4Q6KA 4CPLA 4AGIA 4JF7A 2HU0A 1NCAN 1V0EA 2VSKA 4R40A 3A9GA 4MJUA 2W8BA 1USXA 3TICA 3ZGCA 2AGSA 4YW4A 2BERA 1V3EA 1DIMA 1WP5A 4MZAA 4GZOA 3GVKA 2DG0A 1V3DA 2IAOA 1L7FA 3H6JA 1MS8A 1NNBA 4KS2A 3SANA 1MS1A 2DG1A 4M3MA 4XILA 5FNRA 4GDJA 3TIAA 2CMLA 1NMCA 3T1EA 4K1HA 2VVZA 1IJQA 2AEQA 1SNTA 2H2NA 1PJXA 4B7NA 3B7EA 1SLLA 2SIMA 2SILA 4MC7A 1U6DX 1Z4ZA 4YW5A 1B9SA 2BF6A 1Q7FA 4UF7A 3O4PA 1N1TA 3TI3A 2DYHA 4FPLA 5HX0A 2F10A 3SOVA 2X9MA 2OJHA 1ZI0A 3O9KA 3TI5A 3NN9A 1MS4A 3NO0A 4IFJA 4GB1A 4CHBA 1QBIA 3D11A 1MZ6A 1EUSA 1X2JA 2VW2A 1KITA 1F8EA 3K37A 4FJ6A 2B8HA 2HT8A 4XJRA 4GZPA 4YW1A 2IAVA 1IVBA 1Z4YA 4D52B 2V91A 1VCJA 3DASA 1NCBN 3Q6KA 4FPFA 3B69A 2W8BB 1B9VA 3UC1A 2HTRA 4GZQA 3K38A 4C1YA 4CPOA 4WEFA 2F13A 4HW6A 1A4GA 3CYEA 1NNCA 5D9CA 2FPBA 3DR2A 5B2CA 1EURA 3HLHA 3JU4A 1MS3A 4K1JA 4KS4A 1EUTA 2QE8A 5GX5A 4XMIA 5GX2A 1CQ1A 3LI4A 1Z4XA 2HTWA 4FOQA 1V0FA 5EO8A 1RWIA 2IAUA 1CRUA 5GX4A 1Z50A 4XYXA 4IFNX 1XOGA 3LI3A 2HT5A 2YA4A 2FHRA 4XIOA 2H2UA 2HTUA 3A72A 4HHOA 1INFA 1MS9A 3CL2A 2GVWA 4GZWA 2GHSA 1MR5A 3H72A 4NCSA 1V04A 4L7CA 2ZW9A 5FNQA 1BJIA 1MZ5A 1W8NA 2POOA 2XZIA 5GX1A 5FNTA 4X47A 4KS5A 3PJQA 3WW9A 3H71A 3TIBA 3G4HA 5GX3A 4K1IA 2VK5A 4FVKA 4O5TA 1QLGA 4GDIA 3ADEA 4GN9A 4SLIA 3ALXA 3SLIA 1Z4VA 5HUGA 1V2IA 2C4AA 1NCDN 4M4NA 5H47A 4FPHA 5JYYA 1S18A 3SALA 4B7QA 3HRPA 4YZ1A 3Q6TA 4YZ2A 2ISMA 3U0SA 2Z32A 2HTVA 4C1YB 2IAQA 4X6KA 2SLIA 4J9TA 2XN4A 4FP3A 1S1DA 1WCSA 2FP9A 4XJWA 1POOA 5NN9A 2BATA 4FQ4A 2F27A 2FLUX 4FZHA 3SILA 4FOVA 1DILA 4XJ9A 1L7GA 4HZYA 1NNAA 4QN7A 4I00A 4KS3A 3OPZA 4MWRA 4HZWA 1V0ZA 4HHQA 3TI6A 1EUUA 1NPEA 4XMBA 3A9HA 1IVCA 2VW0A 1C9UA 3GVLA 4IN4A 3IAXA 5FZJA 1WCQA 4O5SA 2IAXA 4B7RA 4QN5A 3TI4A 2QWHA 1IVGA 4KS1A 1W21A 4HZXA 2HU4A 4XJZA 1USRA 2W5NA 2XCYA 3I1CA 4MX0A 1NSCA 2IARA 4AGTA 1NN2A 4XJAA 4XJ8A 1H6LA 3O9JA 4QNPA 4YW3A 4X4AA 4IQKA 1MWEA 4L7DA 2DSOA 3HLIA 3H73A 3W09A 4WA4A 2RKCA 5D9DA 4D4UA 4G3NA 2VSMA 1C5KA 3FVZA 4FPGA 3K3AA 4MWYA 4QN4A 1OFZA 1INWA 1NSBA 4WEGA 2F29A 4CPNA 5EX7A 5D9BA 1S0IA 5HUNA 4CPYA 2VW1A 2ZZKA 4GN8A 1S0JA 1A14N
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4IFN X;  5F72 C;  4IN4 A;  5FZN A;  5FZJ A;  5CGJ A;  1ZGK A;  2XN4 A;  3ZGD A;  3ADE A;  3ZGC A;  2VPJ A;  4ZGC A;  3VNH A;  4CH9 A;  5FNS A;  4IFJ A;  4CHB A;  3II7 A;  2WOZ A;  2FLU X;  4N1B A;  1X2J A;  3WDZ A;  3WN7 A;  4L7C A;  2ZW9 A;  5FNQ A;  4YY8 A;  1U6D X;  4L7B A;  4ASC A;  4IFL X;  5FNT A;  4ZY3 A;  4IQK A;  2DYH A;  4L7D A;  4XMB A;  1X2R A;  2ZZK A;  2Z32 A;  2ZWA A;  3VNG A;  5FNU A;  5FNR A; 
#chains in the Genus database with same CATH topology
 2YA5 A;  2YA8 A;  4FP2 A;  4XHX A;  1SLI A;  4YW2 A;  1ZGK A;  3ZGD A;  1NSD A;  3BEQ A;  4B7J A;  2XZJ A;  3VNH A;  1E8T A;  2GVX A;  1SO7 A;  4GNB A;  1F8D A;  3TC9 A;  4DG6 A;  4UOU A;  4BBW A;  4YZ4 A;  1N1S A;  1INH A;  1VCU A;  2QWG A;  4MWL A;  4WA3 A;  2HTQ A;  1F8C A;  5HUM A;  2VK6 A;  3V65 B;  1X2R A;  2QWI A;  1INV A;  2F0Z A;  1CVM A;  1W1X A;  1IVE A;  1NMB N;  5EO7 A;  2QWD A;  2F26 A;  4XHB A;  2GVU A;  1W8O A;  4GZX A;  2P4O A;  2G8S A;  2VAQ A;  5F9T A;  3ALW A;  4A0P A;  4HZZ A;  1INY A;  2IAW A;  4L7B A;  3NSS A;  2QWC A;  4FPC A;  4CPZ A;  1MS0 A;  4GZS A;  1SUU A;  4D52 A;  4FPK A;  4XJU A;  1RWL A;  4GNA A;  2VWD A;  4XIK A;  5FNU A;  2GVV A;  2YDP A;  4YZ3 A;  4WA5 A;  1E1A A;  1IUC A;  1N7D A;  4H52 A;  1IVD A;  3D12 A;  5M1Z A;  1W20 A;  4FPO B;  1W0P A;  3WDZ A;  3WN7 A;  2ZB6 A;  5GTQ A;  3S94 A;  4MJV A;  1A4Q A;  2HTY A;  3L6V A;  3LI5 A;  2BZD A;  2XZK A;  3V1S A;  2ZWA A;  1N6E A;  2IVZ A;  4GJT A;  2C4L A;  2FPC A;  1XOE A;  4GNC A;  3WWA A;  5HUK A;  2VPJ A;  4DGR A;  3CKZ A;  3FW0 A;  4HIZ A;  4QN3 A;  2F25 A;  5FNS A;  4FPY A;  4HZV A;  4AH4 A;  4GZT A;  2F28 A;  4NN9 A;  4M4U A;  1V3B A;  3KGG A;  4XJQ A;  4ASC A;  1N1V A;  2F24 A;  4M4V A;  2FP8 A;  3SOB B;  4X49 A;  1IVF A;  2AEP A;  3AMR A;  3GVJ A;  4MWV A;  3V64 C;  4IMB A;  2F11 A;  4QN6 A;  3S2K A;  5FWW A;  1IUB A;  3TI8 A;  3INB A;  5F72 C;  5CGJ A;  3E5Z A;  4Q1U A;  4FPJ A;  4XOG A;  3P5B L;  3K36 A;  2QWA A;  3II7 A;  1INX A;  4N1B A;  3SRE A;  4MWQ A;  4AHA A;  3CL0 A;  2YA7 A;  1V3C A;  4NC5 A;  4D8S A;  1F8B A;  4YY8 A;  2IAP A;  4PWZ A;  4IFL X;  1L7H A;  4D52 C;  4GEZ A;  3Q6P A;  2W5O A;  4ZY3 A;  4ZLR A;  4JML A;  2IAT A;  4XMA A;  4FOW A;  2JKB A;  2ZB5 A;  3G4E A;  2HQS A;  3SOQ A;  1W0O A;  4XE9 A;  1K32 A;  3K39 A;  1ING A;  4ZGC A;  4CSD A;  4CH9 A;  4CPM A;  3BYC A;  2A75 A;  1NCC N;  2WOZ A;  4MZE A;  2YDT A;  4YZ5 A;  1N6F A;  2IAS A;  4IYG A;  2AH2 A;  1N6D A;  4GN7 A;  2YA6 A;  4MWJ A;  4FOY A;  5B2D A;  1NMA N;  3KYA A;  3S8V A;  7NN9 A;  4MWU A;  4MWX A;  2W20 A;  2F12 A;  3VNG A;  4K3Y A;  2QWK A;  2W38 A;  5FZN A;  3S8Z A;  1B9T A;  1E8V A;  4MWW A;  4K1K A;  1Z4W A;  6NN9 A;  2QWB A;  3SRG A;  2QWE A;  2HT7 A;  1CRZ A;  1MS5 A;  2VK7 A;  3A71 A;  4FPE A;  1E8U A;  2QWF A;  1N1Y A;  2QWJ A;  4B7M A;  4H53 A;  3AMS A;  4Q6K A;  4CPL A;  4AGI A;  4JF7 A;  2HU0 A;  1NCA N;  1V0E A;  2VSK A;  4R40 A;  3A9G A;  4MJU A;  2W8B A;  1USX A;  3TIC A;  3ZGC A;  2AGS A;  4YW4 A;  2BER A;  1V3E A;  1DIM A;  1WP5 A;  4MZA A;  4GZO A;  3GVK A;  2DG0 A;  1V3D A;  2IAO A;  1L7F A;  3H6J A;  1MS8 A;  1NNB A;  4KS2 A;  3SAN A;  1MS1 A;  2DG1 A;  4M3M A;  4XIL A;  5FNR A;  4GDJ A;  3TIA A;  2CML A;  1NMC A;  3T1E A;  4K1H A;  2VVZ A;  1IJQ A;  2AEQ A;  1SNT A;  2H2N A;  1PJX A;  4B7N A;  3B7E A;  1SLL A;  2SIM A;  2SIL A;  4MC7 A;  1U6D X;  1Z4Z A;  4YW5 A;  1B9S A;  2BF6 A;  1Q7F A;  4UF7 A;  3O4P A;  1N1T A;  3TI3 A;  2DYH A;  4FPL A;  5HX0 A;  2F10 A;  3SOV A;  2X9M A;  2OJH A;  1ZI0 A;  3O9K A;  3TI5 A;  3NN9 A;  1MS4 A;  3NO0 A;  4IFJ A;  4GB1 A;  4CHB A;  1QBI A;  3D11 A;  1MZ6 A;  1EUS A;  1X2J A;  2VW2 A;  1KIT A;  1F8E A;  3K37 A;  4FJ6 A;  2B8H A;  2HT8 A;  4XJR A;  4GZP A;  4YW1 A;  2IAV A;  1IVB A;  1Z4Y A;  4D52 B;  2V91 A;  1VCJ A;  3DAS A;  1NCB N;  3Q6K A;  4FPF A;  3B69 A;  2W8B B;  1B9V A;  3UC1 A;  2HTR A;  4GZQ A;  3K38 A;  4C1Y A;  4CPO A;  4WEF A;  2F13 A;  4HW6 A;  1A4G A;  3CYE A;  1NNC A;  5D9C A;  2FPB A;  3DR2 A;  5B2C A;  1EUR A;  3HLH A;  3JU4 A;  1MS3 A;  4K1J A;  4KS4 A;  1EUT A;  2QE8 A;  5GX5 A;  4XMI A;  5GX2 A;  1CQ1 A;  3LI4 A;  1Z4X A;  2HTW A;  4FOQ A;  1V0F A;  5EO8 A;  1RWI A;  2IAU A;  1CRU A;  5GX4 A;  1Z50 A;  4XYX A;  4IFN X;  1XOG A;  3LI3 A;  2HT5 A;  2YA4 A;  2FHR A;  4XIO A;  2H2U A;  2HTU A;  3A72 A;  4HHO A;  1INF A;  1MS9 A;  3CL2 A;  2GVW A;  4GZW A;  2GHS A;  1MR5 A;  3H72 A;  4NCS A;  1V04 A;  4L7C A;  2ZW9 A;  5FNQ A;  1BJI A;  1MZ5 A;  1W8N A;  2POO A;  2XZI A;  5GX1 A;  5FNT A;  4X47 A;  4KS5 A;  3PJQ A;  3WW9 A;  3H71 A;  3TIB A;  3G4H A;  5GX3 A;  4K1I A;  2VK5 A;  4FVK A;  4O5T A;  1QLG A;  4GDI A;  3ADE A;  4GN9 A;  4SLI A;  3ALX A;  3SLI A;  1Z4V A;  5HUG A;  1V2I A;  2C4A A;  1NCD N;  4M4N A;  5H47 A;  4FPH A;  5JYY A;  1S18 A;  3SAL A;  4B7Q A;  3HRP A;  4YZ1 A;  3Q6T A;  4YZ2 A;  2ISM A;  3U0S A;  2Z32 A;  2HTV A;  4C1Y B;  2IAQ A;  4X6K A;  2SLI A;  4J9T A;  2XN4 A;  4FP3 A;  1S1D A;  1WCS A;  2FP9 A;  4XJW A;  1POO A;  5NN9 A;  2BAT A;  4FQ4 A;  2F27 A;  2FLU X;  4FZH A;  3SIL A;  4FOV A;  1DIL A;  4XJ9 A;  1L7G A;  4HZY A;  1NNA A;  4QN7 A;  4I00 A;  4KS3 A;  3OPZ A;  4MWR A;  4HZW A;  1V0Z A;  4HHQ A;  3TI6 A;  1EUU A;  1NPE A;  4XMB A;  3A9H A;  1IVC A;  2VW0 A;  1C9U A;  3GVL A;  4IN4 A;  3IAX A;  5FZJ A;  1WCQ A;  4O5S A;  2IAX A;  4B7R A;  4QN5 A;  3TI4 A;  2QWH A;  1IVG A;  4KS1 A;  1W21 A;  4HZX A;  2HU4 A;  4XJZ A;  1USR A;  2W5N A;  2XCY A;  3I1C A;  4MX0 A;  1NSC A;  2IAR A;  4AGT A;  1NN2 A;  4XJA A;  4XJ8 A;  1H6L A;  3O9J A;  4QNP A;  4YW3 A;  4X4A A;  4IQK A;  1MWE A;  4L7D A;  2DSO A;  3HLI A;  3H73 A;  3W09 A;  4WA4 A;  2RKC A;  5D9D A;  4D4U A;  4G3N A;  2VSM A;  1C5K A;  3FVZ A;  4FPG A;  3K3A A;  4MWY A;  4QN4 A;  1OFZ A;  1INW A;  1NSB A;  4WEG A;  2F29 A;  4CPN A;  5EX7 A;  5D9B A;  1S0I A;  5HUN A;  4CPY A;  2VW1 A;  2ZZK A;  4GN8 A;  1S0J A;  1A14 N; 
#chains in the Genus database with same CATH homology
 4IFN X;  5F72 C;  4IN4 A;  5FZN A;  5FZJ A;  5CGJ A;  1ZGK A;  2XN4 A;  3ZGD A;  3ADE A;  3ZGC A;  2VPJ A;  4ZGC A;  3VNH A;  4CH9 A;  5FNS A;  4IFJ A;  4CHB A;  3II7 A;  2WOZ A;  2FLU X;  4N1B A;  1X2J A;  3WDZ A;  3WN7 A;  4L7C A;  2ZW9 A;  5FNQ A;  4YY8 A;  1U6D X;  4L7B A;  4ASC A;  4IFL X;  5FNT A;  4ZY3 A;  4IQK A;  2DYH A;  4L7D A;  4XMB A;  1X2R A;  2ZZK A;  2Z32 A;  2ZWA A;  3VNG A;  5FNU A;  5FNR A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

4N1BA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations