4XMBA

Crystal structure of 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetamide bound to human keap1 kelch domain
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
286
structure length
286
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
pubmed doi rcsb
molecule keywords Kelch-like ECH-associated protein 1
molecule tags Protein binding
source organism Homo sapiens
total genus 64
structure length 286
sequence length 286
ec nomenclature
pdb deposition date 2015-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4xmbA00
1U6DX 4IFNX 3WDZA 4ASCA 4ZY3A 2Z32A 5CGJA 4L7CA 1X2JA 3VNGA 5FZNA 3VNHA 4L7BA 2XN4A 4CH9A 2WOZA 4IQKA 5FNTA 3ADEA 1X2RA 4YY8A 2VPJA 2DYHA 3II7A 5FNSA 2ZWAA 5F72C 5FNQA 4IN4A 4IFLX 3ZGDA 4XMBA 4N1BA 2FLUX 4L7DA 4ZGCA 4CHBA 2ZW9A 4IFJA 5FZJA 2ZZKA 5FNUA 1ZGKA 3WN7A 5FNRA 3ZGCA
chains in the Genus database with same CATH superfamily
3AMRA 1U6DX 4YZ4A 2IATA 2DG1A 1IVDA 4CH9A 2QWAA 4WEGA 2CMLA 2YA5A 1W20A 5GX5A 4GN8A 2W8BB 4HZZA 2SILA 4AHAA 2ZW9A 2VK7A 2IAOA 1CRZA 1V0FA 2IAXA 2GHSA 2YDTA 4HW6A 5F9TA 3HLHA 1NCBN 4HZYA 4IFNX 1S1DA 2BF6A 2XZIA 1B9TA 2G8SA 4M4NA 5EO7A 4L7BA 3GVLA 1W8NA 2F12A 3SREA 7NN9A 1E1AA 1C5KA 1MS1A 4SLIA 4XJ8A 3CL2A 5HUKA 4MX0A 1A14N 2DYHA 2HTWA 4AGTA 2QWBA 3BEQA 5F72C 2VSKA 3SRGA 3LI3A 4MWLA 2P4OA 1V3BA 4FPJA 2IAWA 2F26A 4D52A 2QWDA 3H72A 5FNRA 1Q7FA 1QBIA 1B9VA 1WP5A 1EUTA 3FW0A 3TIAA 4ZY3A 4GZXA 4Q1UA 1USRA 4PWZA 3KGGA 4KS3A 1V3EA 3D11A 4GN7A 4IQKA 1MS9A 1WCQA 1VCUA 2IASA 4YY8A 2GVWA 4XJZA 2W5OA 4XMIA 3IAXA 3G4EA 2BERA 4HHQA 4IMBA 1Z4ZA 5FZJA 1XOEA 3SLIA 3TC9A 4KS5A 2F25A 4XJWA 4WA3A 4M4VA 5HUNA 1INVA 1KITA 2YA6A 1W1XA 1RWLA 3S2KA 4GZSA 1H6LA 2ZB6A 3S8VA 2HU4A 1C9UA 1USXA 4KS2A 1B9SA 1BJIA 2VPJA 4FPCA 1RWIA 4CHBA 1L7FA 4XYXA 1V04A 3CYEA 4M3MA 2AEQA 2XZKA 1IUBA 2W20A 4I00A 4NN9A 2F28A 3S94A 4ASCA 3H73A 2VK6A 3W09A 4MWVA 4QN7A 4FJ6A 2HTYA 2YDPA 5FNTA 4MWJA 3SOQA 5GX4A 3CKZA 2VK5A 4YZ2A 1NNCA 5M1ZA 5EO8A 4MZAA 4GN9A 1NN2A 2SIMA 5H47A 2SLIA 1ZGKA 4HZXA 1INHA 4MC7A 4B7NA 2JKBA 3SOBB 3K38A 1V3DA 4IYGA 1X2JA 4NCSA 1L7GA 4GZTA 2VW2A 3TI6A 3NSSA 2IAPA 4JF7A 1NNBA 3TI5A 4B7RA 2FHRA 2QWJA 2HTQA 4FZHA 4DG6A 2FP9A 4IFLX 4QN3A 2A75A 4IFJA 4KS1A 2XCYA 4UOUA 2XZJA 2V91A 1XOGA 4KS4A 2HQSA 4MWQA 1F8BA 5FZNA 4YW3A 4XMAA 2HT7A 1CVMA 4GB1A 3HRPA 3ADEA 4FVKA 2BZDA 4CPMA 4ZLRA 1MS8A 4FPEA 2F29A 2F11A 2W8BA 1F8CA 3D12A 1N1YA 3JU4A 2QWKA 3V64C 2AGSA 4MZEA 1QLGA 4X47A 3ZGCA 1S18A 4GNCA 2DG0A 4FP2A 1V3CA 2X9MA 4YW4A 1K32A 1IUCA 1IVBA 1EUUA 1CRUA 4GZWA 4FOWA 2IAVA 4YW5A 2WOZA 1NCCN 3CL0A 1SO7A 4CPYA 1INFA 1CQ1A 4B7MA 1W21A 5GX1A 4B7QA 4B7JA 4FQ4A 2YA8A 3K36A 1E8VA 2VW0A 2IAUA 3V65B 3GVKA 1SNTA 2F10A 4QNPA 2VWDA 3WDZA 1NSCA 5GTQA 4L7CA 3VNGA 5GX2A 4YZ3A 3O9KA 4D4UA 2VVZA 4MWYA 4H53A 3INBA 4QN6A 4FOYA 1A4GA 2YA4A 4K1KA 1F8EA 2ZWAA 1EUSA 5D9DA 5EX7A 1MR5A 1N6FA 4MWWA 4O5TA 4GNBA 1SLLA 4BBWA 5B2CA 2QWGA 2DSOA 4WA5A 1MS3A 2HTRA 1Z4VA 4QN5A 4CPZA 1S0IA 4K3YA 4FPGA 2OJHA 2YA7A 5FWWA 5D9CA 3VNHA 4XJ9A 1V2IA 2HT8A 2IVZA 4MJVA 1NMCA 4MJUA 3HLIA 4FPKA 5NN9A 2FPCA 3SANA 2B8HA 3U0SA 4HHOA 3TI3A 4FOQA 2GVUA 3DR2A 4CSDA 3S8ZA 3WN7A 1NSBA 3A9HA 2IAQA 4XHBA 2RKCA 4GEZA 1DILA 3P5BL 4CPLA 4GDIA 4YW2A 3ALWA 3A72A 4XIKA 4K1JA 3UC1A 3E5ZA 4HZWA 5JYYA 2QWEA 2VW1A 2C4LA 2W38A 4AH4A 3LI5A 4K1HA 2W5NA 6NN9A 1N7DA 1INYA 3K39A 4M4UA 1N1TA 2QWFA 2QWCA 2GVXA 4J9TA 4O5SA 2HTVA 3H6JA 5FNUA 4YZ5A 4HIZA 1N1VA 1SUUA 4XJAA 3WWAA 4XIOA 4XJQA 3AMSA 4G3NA 4AGIA 3KYAA 3OPZA 1L7HA 2H2NA 2AH2A 1NMAN 4XHXA 1SLIA 4XILA 3G4HA 5D9BA 4YW1A 4QN4A 4D8SA 2C4AA 3II7A 2HTUA 4FPYA 5FNQA 1S0JA 4GNAA 4C1YB 4D52B 4N1BA 1NSDA 3B7EA 3Q6KA 4FPLA 4JMLA 1MS5A 1V0EA 3I1CA 4XJUA 4CPNA 4ZGCA 3BYCA 3WW9A 4DGRA 1W0OA 3PJQA 5HX0A 2QE8A 3TIBA 1N6DA 4H52A 4NC5A 4MWRA 1MS0A 4FPOB 4X49A 1IJQA 1INWA 4K1IA 2QWIA 4XJRA 4GZPA 3A9GA 3A71A 4MWUA 5FNSA 1VCJA 2HU0A 3V1SA 4C1YA 3K37A 3O4PA 1W8OA 3NN9A 4FP3A 3DASA 3O9JA 4CPOA 3SILA 2VSMA 4A0PA 1F8DA 5CGJA 4GZQA 2VAQA 1Z4XA 2F24A 1E8UA 4XE9A 1WCSA 1MS4A 1IVCA 1MZ5A 2HT5A 1IVFA 2H2UA 4D52C 3L6VA 4R40A 3FVZA 3ZGDA 1DIMA 2FLUX 4L7DA 4WEFA 2F13A 1POOA 3LI4A 2AEPA 3B69A 1INGA 1ZI0A 4X6KA 2ZB5A 3NO0A 1IVGA 3TI4A 4Q6KA 2FP8A 2F0ZA 4UF7A 2F27A 2IARA 5HUMA 1MWEA 4XOGA 4WA4A 4FPHA 3Q6PA 2FPBA 1INXA 1V0ZA 1IVEA 3GVJA 1NMBN 1Z4YA 3SOVA 1MZ6A 4IN4A 1NNAA 4XMBA 4YZ1A 2POOA 4GDJA 1A4QA 1Z4WA 1N6EA 4MWXA 3H71A 3TI8A 5HUGA 3TICA 4HZVA 2ISMA 1E8TA 2Z32A 1Z50A 2XN4A 1NCDN 2QWHA 2BATA 1X2RA 1NPEA 1OFZA 3T1EA 1NCAN 1PJXA 1N1SA 5GX3A 4GJTA 3Q6TA 2GVVA 4FOVA 3K3AA 4GZOA 4X4AA 4FPFA 3SALA 2ZZKA 1W0PA 1EURA 3ALXA 5B2DA
chains in the Genus database with same CATH topology
1U6DX 4IFNX 3WDZA 4ASCA 4ZY3A 2Z32A 5CGJA 4L7CA 1X2JA 3VNGA 5FZNA 3VNHA 4L7BA 2XN4A 4CH9A 2WOZA 4IQKA 5FNTA 3ADEA 1X2RA 4YY8A 2VPJA 2DYHA 3II7A 5FNSA 2ZWAA 5F72C 5FNQA 4IN4A 4IFLX 3ZGDA 4XMBA 4N1BA 2FLUX 4L7DA 4ZGCA 4CHBA 2ZW9A 4IFJA 5FZJA 2ZZKA 5FNUA 1ZGKA 3WN7A 5FNRA 3ZGCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U6D X;  4IFN X;  3WDZ A;  4ASC A;  4ZY3 A;  2Z32 A;  5CGJ A;  4L7C A;  1X2J A;  3VNG A;  5FZN A;  3VNH A;  4L7B A;  2XN4 A;  4CH9 A;  2WOZ A;  4IQK A;  5FNT A;  3ADE A;  1X2R A;  4YY8 A;  2VPJ A;  2DYH A;  3II7 A;  5FNS A;  2ZWA A;  5F72 C;  5FNQ A;  4IN4 A;  4IFL X;  3ZGD A;  4XMB A;  4N1B A;  2FLU X;  4L7D A;  4ZGC A;  4CHB A;  2ZW9 A;  4IFJ A;  5FZJ A;  2ZZK A;  5FNU A;  1ZGK A;  3WN7 A;  5FNR A;  3ZGC A; 
#chains in the Genus database with same CATH topology
 3AMR A;  1U6D X;  4YZ4 A;  2IAT A;  2DG1 A;  1IVD A;  4CH9 A;  2QWA A;  4WEG A;  2CML A;  2YA5 A;  1W20 A;  5GX5 A;  4GN8 A;  2W8B B;  4HZZ A;  2SIL A;  4AHA A;  2ZW9 A;  2VK7 A;  2IAO A;  1CRZ A;  1V0F A;  2IAX A;  2GHS A;  2YDT A;  4HW6 A;  5F9T A;  3HLH A;  1NCB N;  4HZY A;  4IFN X;  1S1D A;  2BF6 A;  2XZI A;  1B9T A;  2G8S A;  4M4N A;  5EO7 A;  4L7B A;  3GVL A;  1W8N A;  2F12 A;  3SRE A;  7NN9 A;  1E1A A;  1C5K A;  1MS1 A;  4SLI A;  4XJ8 A;  3CL2 A;  5HUK A;  4MX0 A;  1A14 N;  2DYH A;  2HTW A;  4AGT A;  2QWB A;  3BEQ A;  5F72 C;  2VSK A;  3SRG A;  3LI3 A;  4MWL A;  2P4O A;  1V3B A;  4FPJ A;  2IAW A;  2F26 A;  4D52 A;  2QWD A;  3H72 A;  5FNR A;  1Q7F A;  1QBI A;  1B9V A;  1WP5 A;  1EUT A;  3FW0 A;  3TIA A;  4ZY3 A;  4GZX A;  4Q1U A;  1USR A;  4PWZ A;  3KGG A;  4KS3 A;  1V3E A;  3D11 A;  4GN7 A;  4IQK A;  1MS9 A;  1WCQ A;  1VCU A;  2IAS A;  4YY8 A;  2GVW A;  4XJZ A;  2W5O A;  4XMI A;  3IAX A;  3G4E A;  2BER A;  4HHQ A;  4IMB A;  1Z4Z A;  5FZJ A;  1XOE A;  3SLI A;  3TC9 A;  4KS5 A;  2F25 A;  4XJW A;  4WA3 A;  4M4V A;  5HUN A;  1INV A;  1KIT A;  2YA6 A;  1W1X A;  1RWL A;  3S2K A;  4GZS A;  1H6L A;  2ZB6 A;  3S8V A;  2HU4 A;  1C9U A;  1USX A;  4KS2 A;  1B9S A;  1BJI A;  2VPJ A;  4FPC A;  1RWI A;  4CHB A;  1L7F A;  4XYX A;  1V04 A;  3CYE A;  4M3M A;  2AEQ A;  2XZK A;  1IUB A;  2W20 A;  4I00 A;  4NN9 A;  2F28 A;  3S94 A;  4ASC A;  3H73 A;  2VK6 A;  3W09 A;  4MWV A;  4QN7 A;  4FJ6 A;  2HTY A;  2YDP A;  5FNT A;  4MWJ A;  3SOQ A;  5GX4 A;  3CKZ A;  2VK5 A;  4YZ2 A;  1NNC A;  5M1Z A;  5EO8 A;  4MZA A;  4GN9 A;  1NN2 A;  2SIM A;  5H47 A;  2SLI A;  1ZGK A;  4HZX A;  1INH A;  4MC7 A;  4B7N A;  2JKB A;  3SOB B;  3K38 A;  1V3D A;  4IYG A;  1X2J A;  4NCS A;  1L7G A;  4GZT A;  2VW2 A;  3TI6 A;  3NSS A;  2IAP A;  4JF7 A;  1NNB A;  3TI5 A;  4B7R A;  2FHR A;  2QWJ A;  2HTQ A;  4FZH A;  4DG6 A;  2FP9 A;  4IFL X;  4QN3 A;  2A75 A;  4IFJ A;  4KS1 A;  2XCY A;  4UOU A;  2XZJ A;  2V91 A;  1XOG A;  4KS4 A;  2HQS A;  4MWQ A;  1F8B A;  5FZN A;  4YW3 A;  4XMA A;  2HT7 A;  1CVM A;  4GB1 A;  3HRP A;  3ADE A;  4FVK A;  2BZD A;  4CPM A;  4ZLR A;  1MS8 A;  4FPE A;  2F29 A;  2F11 A;  2W8B A;  1F8C A;  3D12 A;  1N1Y A;  3JU4 A;  2QWK A;  3V64 C;  2AGS A;  4MZE A;  1QLG A;  4X47 A;  3ZGC A;  1S18 A;  4GNC A;  2DG0 A;  4FP2 A;  1V3C A;  2X9M A;  4YW4 A;  1K32 A;  1IUC A;  1IVB A;  1EUU A;  1CRU A;  4GZW A;  4FOW A;  2IAV A;  4YW5 A;  2WOZ A;  1NCC N;  3CL0 A;  1SO7 A;  4CPY A;  1INF A;  1CQ1 A;  4B7M A;  1W21 A;  5GX1 A;  4B7Q A;  4B7J A;  4FQ4 A;  2YA8 A;  3K36 A;  1E8V A;  2VW0 A;  2IAU A;  3V65 B;  3GVK A;  1SNT A;  2F10 A;  4QNP A;  2VWD A;  3WDZ A;  1NSC A;  5GTQ A;  4L7C A;  3VNG A;  5GX2 A;  4YZ3 A;  3O9K A;  4D4U A;  2VVZ A;  4MWY A;  4H53 A;  3INB A;  4QN6 A;  4FOY A;  1A4G A;  2YA4 A;  4K1K A;  1F8E A;  2ZWA A;  1EUS A;  5D9D A;  5EX7 A;  1MR5 A;  1N6F A;  4MWW A;  4O5T A;  4GNB A;  1SLL A;  4BBW A;  5B2C A;  2QWG A;  2DSO A;  4WA5 A;  1MS3 A;  2HTR A;  1Z4V A;  4QN5 A;  4CPZ A;  1S0I A;  4K3Y A;  4FPG A;  2OJH A;  2YA7 A;  5FWW A;  5D9C A;  3VNH A;  4XJ9 A;  1V2I A;  2HT8 A;  2IVZ A;  4MJV A;  1NMC A;  4MJU A;  3HLI A;  4FPK A;  5NN9 A;  2FPC A;  3SAN A;  2B8H A;  3U0S A;  4HHO A;  3TI3 A;  4FOQ A;  2GVU A;  3DR2 A;  4CSD A;  3S8Z A;  3WN7 A;  1NSB A;  3A9H A;  2IAQ A;  4XHB A;  2RKC A;  4GEZ A;  1DIL A;  3P5B L;  4CPL A;  4GDI A;  4YW2 A;  3ALW A;  3A72 A;  4XIK A;  4K1J A;  3UC1 A;  3E5Z A;  4HZW A;  5JYY A;  2QWE A;  2VW1 A;  2C4L A;  2W38 A;  4AH4 A;  3LI5 A;  4K1H A;  2W5N A;  6NN9 A;  1N7D A;  1INY A;  3K39 A;  4M4U A;  1N1T A;  2QWF A;  2QWC A;  2GVX A;  4J9T A;  4O5S A;  2HTV A;  3H6J A;  5FNU A;  4YZ5 A;  4HIZ A;  1N1V A;  1SUU A;  4XJA A;  3WWA A;  4XIO A;  4XJQ A;  3AMS A;  4G3N A;  4AGI A;  3KYA A;  3OPZ A;  1L7H A;  2H2N A;  2AH2 A;  1NMA N;  4XHX A;  1SLI A;  4XIL A;  3G4H A;  5D9B A;  4YW1 A;  4QN4 A;  4D8S A;  2C4A A;  3II7 A;  2HTU A;  4FPY A;  5FNQ A;  1S0J A;  4GNA A;  4C1Y B;  4D52 B;  4N1B A;  1NSD A;  3B7E A;  3Q6K A;  4FPL A;  4JML A;  1MS5 A;  1V0E A;  3I1C A;  4XJU A;  4CPN A;  4ZGC A;  3BYC A;  3WW9 A;  4DGR A;  1W0O A;  3PJQ A;  5HX0 A;  2QE8 A;  3TIB A;  1N6D A;  4H52 A;  4NC5 A;  4MWR A;  1MS0 A;  4FPO B;  4X49 A;  1IJQ A;  1INW A;  4K1I A;  2QWI A;  4XJR A;  4GZP A;  3A9G A;  3A71 A;  4MWU A;  5FNS A;  1VCJ A;  2HU0 A;  3V1S A;  4C1Y A;  3K37 A;  3O4P A;  1W8O A;  3NN9 A;  4FP3 A;  3DAS A;  3O9J A;  4CPO A;  3SIL A;  2VSM A;  4A0P A;  1F8D A;  5CGJ A;  4GZQ A;  2VAQ A;  1Z4X A;  2F24 A;  1E8U A;  4XE9 A;  1WCS A;  1MS4 A;  1IVC A;  1MZ5 A;  2HT5 A;  1IVF A;  2H2U A;  4D52 C;  3L6V A;  4R40 A;  3FVZ A;  3ZGD A;  1DIM A;  2FLU X;  4L7D A;  4WEF A;  2F13 A;  1POO A;  3LI4 A;  2AEP A;  3B69 A;  1ING A;  1ZI0 A;  4X6K A;  2ZB5 A;  3NO0 A;  1IVG A;  3TI4 A;  4Q6K A;  2FP8 A;  2F0Z A;  4UF7 A;  2F27 A;  2IAR A;  5HUM A;  1MWE A;  4XOG A;  4WA4 A;  4FPH A;  3Q6P A;  2FPB A;  1INX A;  1V0Z A;  1IVE A;  3GVJ A;  1NMB N;  1Z4Y A;  3SOV A;  1MZ6 A;  4IN4 A;  1NNA A;  4XMB A;  4YZ1 A;  2POO A;  4GDJ A;  1A4Q A;  1Z4W A;  1N6E A;  4MWX A;  3H71 A;  3TI8 A;  5HUG A;  3TIC A;  4HZV A;  2ISM A;  1E8T A;  2Z32 A;  1Z50 A;  2XN4 A;  1NCD N;  2QWH A;  2BAT A;  1X2R A;  1NPE A;  1OFZ A;  3T1E A;  1NCA N;  1PJX A;  1N1S A;  5GX3 A;  4GJT A;  3Q6T A;  2GVV A;  4FOV A;  3K3A A;  4GZO A;  4X4A A;  4FPF A;  3SAL A;  2ZZK A;  1W0P A;  1EUR A;  3ALX A;  5B2D A; 
#chains in the Genus database with same CATH homology
 1U6D X;  4IFN X;  3WDZ A;  4ASC A;  4ZY3 A;  2Z32 A;  5CGJ A;  4L7C A;  1X2J A;  3VNG A;  5FZN A;  3VNH A;  4L7B A;  2XN4 A;  4CH9 A;  2WOZ A;  4IQK A;  5FNT A;  3ADE A;  1X2R A;  4YY8 A;  2VPJ A;  2DYH A;  3II7 A;  5FNS A;  2ZWA A;  5F72 C;  5FNQ A;  4IN4 A;  4IFL X;  3ZGD A;  4XMB A;  4N1B A;  2FLU X;  4L7D A;  4ZGC A;  4CHB A;  2ZW9 A;  4IFJ A;  5FZJ A;  2ZZK A;  5FNU A;  1ZGK A;  3WN7 A;  5FNR A;  3ZGC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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