4CH9A

Crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
286
structure length
286
Chain Sequence
PKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
pubmed doi rcsb
molecule tags Signaling protein/transferase
source organism Homo sapiens
molecule keywords KELCH-LIKE PROTEIN 3
total genus 67
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4ch9A00
2ZWAA 2XN4A 3ZGDA 4IN4A 4ZY3A 4XMBA 4N1BA 1X2JA 5FNQA 3ADEA 2WOZA 2ZW9A 5F72C 4ZGCA 2VPJA 5FNRA 5FNUA 5FNSA 4L7DA 5FNTA 4CHBA 4L7CA 5CGJA 4YY8A 4IQKA 1U6DX 2DYHA 3ZGCA 3VNGA 5FZJA 2ZZKA 4IFJA 2Z32A 1X2RA 3II7A 2FLUX 4L7BA 1ZGKA 4CH9A 4IFLX 4IFNX 3WN7A 4ASCA 3WDZA 5FZNA 3VNHA
chains in the Genus database with same CATH superfamily
2HU4A 1IUCA 4KS4A 4R40A 4IYGA 4XHXA 5FNRA 3NN9A 1V3DA 1E1AA 2YA5A 3K37A 3TI5A 1E8TA 4B7RA 4L7CA 1WCQA 4CHBA 4MWWA 6NN9A 4YY8A 2HTWA 2VK5A 4GZPA 4Q6KA 4XJ9A 4YZ2A 4CPZA 2F25A 1NNAA 1N6DA 3UC1A 3K3AA 1H6LA 2POOA 2YA7A 1IJQA 2QWJA 4QNPA 1IVGA 3ZGDA 4NC5A 3Q6KA 4ZGCA 2OJHA 1W8OA 3S94A 4HZXA 1WP5A 5EO7A 1N1VA 2VK6A 4DGRA 2ZB5A 1ZI0A 1INFA 2QWEA 4IFJA 2SILA 1K32A 1N1TA 3TI3A 3K36A 4SLIA 5EO8A 3AMRA 4FPEA 1S18A 2GHSA 1V04A 3ALXA 4ZLRA 3B7EA 4JMLA 4D52A 3GVLA 5GX3A 4M3MA 4L7DA 4AGIA 2XZKA 1SUUA 3G4HA 2HTRA 3E5ZA 2B8HA 1RWIA 1QBIA 1QLGA 1V3BA 1SO7A 1V0ZA 2VWDA 1INWA 1B9SA 4MWJA 2P4OA 1F8DA 3II7A 2W20A 2W38A 2XZIA 4G3NA 3TIAA 1CQ1A 1V0EA 5NN9A 1Z4WA 1IVFA 3DR2A 4FOQA 4FVKA 5GTQA 1X2JA 1NCBN 4GZTA 1W8NA 4XJZA 1Z4XA 1CVMA 3A72A 4QN7A 4XOGA 3O9JA 4GNCA 4GN7A 1NN2A 2QWGA 2F0ZA 2Z32A 4Q1UA 5GX5A 2H2NA 1WCSA 4L7BA 7NN9A 1IVCA 1RWLA 1N1SA 4QN3A 4YW5A 3KYAA 4XILA 4GDIA 3A9HA 2F27A 2HTUA 4IN4A 1NMBN 4MWXA 3FW0A 5GX2A 4YW2A 2ZB6A 4XE9A 5JYYA 2F12A 1MWEA 2HT8A 1KITA 2JKBA 3H72A 3P5BL 1U6DX 1Z4ZA 2HT7A 1BJIA 1NMAN 4D52B 1SLIA 4IMBA 1A4GA 1IVEA 1EUUA 1S1DA 2IAQA 5FZJA 2FP8A 2YDTA 4XJUA 3SILA 2VVZA 3TC9A 4AGTA 2YA4A 4HZZA 1INGA 3WDZA 4MWYA 2XN4A 4X49A 2AEPA 4XJRA 1Z4VA 2QWBA 4M4UA 5FWWA 4GNAA 4WA3A 4GN9A 4CPNA 1NCCN 1OFZA 4GZOA 2ISMA 4FPYA 2H2UA 1C9UA 3Q6PA 1X2RA 1XOEA 3H6JA 5HUNA 2F29A 3TIBA 1S0IA 4BBWA 5HUGA 5D9DA 2ZWAA 2QWKA 4FPHA 2GVVA 4XHBA 4AH4A 4K1IA 2W8BA 3H71A 1A4QA 1VCUA 2GVXA 4QN5A 4FP3A 1USRA 3SLIA 3BYCA 4B7JA 3L6VA 4MJUA 3SALA 1IVBA 1ZGKA 3FVZA 2FPCA 4FOYA 4C1YA 4YZ3A 4JF7A 1CRZA 3VNHA 4XMIA 3LI3A 4D52C 5F72C 2VPJA 2VAQA 2VW1A 4FPLA 3A9GA 5M1ZA 3OPZA 3GVKA 2F13A 1Q7FA 1NMCA 5HUMA 3S8VA 3VNGA 2F10A 4GB1A 2QWFA 4AHAA 1N6FA 4YW4A 1MS3A 4DG6A 3LI4A 1F8BA 5H47A 3SOQA 3SOBB 2FHRA 5EX7A 1DILA 3S8ZA 2IAPA 4FPKA 4HIZA 4GNBA 4UF7A 4J9TA 5HX0A 1EUSA 4IQKA 3G4EA 1L7GA 1MZ6A 2DYHA 2W8BB 2QE8A 4MJVA 4MWRA 2VSKA 2X9MA 2BATA 3HLHA 4FPJA 4KS1A 5B2CA 3A71A 4HHQA 4IFNX 4XIOA 4YZ4A 3ALWA 4CPYA 1SLLA 4X4AA 4HZWA 5FNQA 2BZDA 4D4UA 4QN4A 1MS0A 2HT5A 4MX0A 1INXA 3V64C 4C1YB 1NNCA 2C4LA 4WEFA 2RKCA 3INBA 1NSDA 4KS5A 5GX1A 1N1YA 2HTQA 2QWIA 4GN8A 1CRUA 1V0FA 3NO0A 1NSCA 1MS8A 4WA5A 3WWAA 4IFLX 1IUBA 2VW2A 4HZVA 4WA4A 4XJWA 4CPLA 1S0JA 2IAXA 3BEQA 1B9TA 1INYA 2GVWA 1V3EA 3I1CA 1W0OA 5FNSA 3GVJA 2QWHA 4MWLA 1L7HA 4QN6A 2GVUA 1Z4YA 2YDPA 5CGJA 2DSOA 2AH2A 1NCAN 2HU0A 2VK7A 4K1KA 4CPOA 2F24A 3HRPA 4X6KA 4O5TA 5HUKA 3DASA 4KS2A 3S2KA 2AGSA 3WN7A 2IAVA 4B7NA 4MWVA 4UOUA 3CL2A 3W09A 1NCDN 4ZY3A 1MZ5A 2VSMA 4FOVA 3ADEA 4I00A 2HTYA 3TI4A 1L7FA 3AMSA 1NPEA 4H52A 1MR5A 1EURA 2CMLA 4PWZA 1INHA 4K1HA 1MS5A 2DG0A 1NSBA 2XZJA 4FP2A 4D8SA 4YW1A 4MWUA 4X47A 1W20A 2QWAA 1E8UA 4XMAA 2FLUX 3JU4A 3KGGA 1E8VA 1MS9A 1XOGA 2C4AA 3B69A 2HQSA 4GZSA 4FZHA 3WW9A 2IAUA 2YA8A 3TICA 5F9TA 2QWCA 2IARA 2ZW9A 3K38A 2DG1A 1IVDA 1EUTA 4CSDA 4FQ4A 4NCSA 4FJ6A 2BF6A 1USXA 2YA6A 4MZAA 2W5NA 3TI6A 3ZGCA 2ZZKA 4HHOA 2IVZA 2G8SA 3O9KA 2FP9A 2SIMA 4GZXA 4CH9A 3CL0A 4K1JA 4ASCA 4YZ1A 1A14N 3V1SA 3U0SA 4YZ5A 4XMBA 3IAXA 3H73A 1V2IA 5FNUA 4XJ8A 3Q6TA 3LI5A 2HTVA 2V91A 4FPCA 3TI8A 2VW0A 3PJQA 1POOA 1VCJA 1DIMA 1PJXA 4GJTA 2AEQA 1Z50A 2IAOA 2XCYA 1MS1A 2SLIA 2IATA 4HZYA 1NNBA 1SNTA 5D9CA 2F11A 5FZNA 1INVA 5GX4A 4N1BA 2WOZA 4WEGA 1V3CA 5FNTA 2QWDA 3NSSA 4A0PA 4GZWA 4KS3A 1W1XA 4GZQA 4XJAA 3CYEA 4NN9A 3SREA 4B7QA 4FOWA 4CPMA 1W21A 4MC7A 2A75A 1N7DA 2IASA 4O5SA 3CKZA 4M4VA 4GEZA 1N6EA 4XYXA 1B9VA 4K3YA 1W0PA 2F26A 2W5OA 4FPFA 3SRGA 1F8EA 3V65B 3D12A 4YW3A 4FPOB 2FPBA 4XJQA 4XIKA 1F8CA 3T1EA 4MZEA 3O4PA 4HW6A 4H53A 3HLIA 4GDJA 4M4NA 2BERA 2F28A 5B2DA 3SANA 5D9BA 2IAWA 4FPGA 3D11A 4B7MA 3K39A 3SOVA 1MS4A 4MWQA 1C5KA
chains in the Genus database with same CATH topology
2ZWAA 2XN4A 3ZGDA 4IN4A 4ZY3A 4XMBA 4N1BA 1X2JA 5FNQA 3ADEA 2WOZA 2ZW9A 5F72C 4ZGCA 2VPJA 5FNRA 5FNUA 5FNSA 4L7DA 5FNTA 4CHBA 4L7CA 5CGJA 4YY8A 4IQKA 1U6DX 2DYHA 3ZGCA 3VNGA 5FZJA 2ZZKA 4IFJA 2Z32A 1X2RA 3II7A 2FLUX 4L7BA 1ZGKA 4CH9A 4IFLX 4IFNX 3WN7A 4ASCA 3WDZA 5FZNA 3VNHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZWA A;  2XN4 A;  3ZGD A;  4IN4 A;  4ZY3 A;  4XMB A;  4N1B A;  1X2J A;  5FNQ A;  3ADE A;  2WOZ A;  2ZW9 A;  5F72 C;  4ZGC A;  2VPJ A;  5FNR A;  5FNU A;  5FNS A;  4L7D A;  5FNT A;  4CHB A;  4L7C A;  5CGJ A;  4YY8 A;  4IQK A;  1U6D X;  2DYH A;  3ZGC A;  3VNG A;  5FZJ A;  2ZZK A;  4IFJ A;  2Z32 A;  1X2R A;  3II7 A;  2FLU X;  4L7B A;  1ZGK A;  4CH9 A;  4IFL X;  4IFN X;  3WN7 A;  4ASC A;  3WDZ A;  5FZN A;  3VNH A; 
#chains in the Genus database with same CATH topology
 2HU4 A;  1IUC A;  4KS4 A;  4R40 A;  4IYG A;  4XHX A;  5FNR A;  3NN9 A;  1V3D A;  1E1A A;  2YA5 A;  3K37 A;  3TI5 A;  1E8T A;  4B7R A;  4L7C A;  1WCQ A;  4CHB A;  4MWW A;  6NN9 A;  4YY8 A;  2HTW A;  2VK5 A;  4GZP A;  4Q6K A;  4XJ9 A;  4YZ2 A;  4CPZ A;  2F25 A;  1NNA A;  1N6D A;  3UC1 A;  3K3A A;  1H6L A;  2POO A;  2YA7 A;  1IJQ A;  2QWJ A;  4QNP A;  1IVG A;  3ZGD A;  4NC5 A;  3Q6K A;  4ZGC A;  2OJH A;  1W8O A;  3S94 A;  4HZX A;  1WP5 A;  5EO7 A;  1N1V A;  2VK6 A;  4DGR A;  2ZB5 A;  1ZI0 A;  1INF A;  2QWE A;  4IFJ A;  2SIL A;  1K32 A;  1N1T A;  3TI3 A;  3K36 A;  4SLI A;  5EO8 A;  3AMR A;  4FPE A;  1S18 A;  2GHS A;  1V04 A;  3ALX A;  4ZLR A;  3B7E A;  4JML A;  4D52 A;  3GVL A;  5GX3 A;  4M3M A;  4L7D A;  4AGI A;  2XZK A;  1SUU A;  3G4H A;  2HTR A;  3E5Z A;  2B8H A;  1RWI A;  1QBI A;  1QLG A;  1V3B A;  1SO7 A;  1V0Z A;  2VWD A;  1INW A;  1B9S A;  4MWJ A;  2P4O A;  1F8D A;  3II7 A;  2W20 A;  2W38 A;  2XZI A;  4G3N A;  3TIA A;  1CQ1 A;  1V0E A;  5NN9 A;  1Z4W A;  1IVF A;  3DR2 A;  4FOQ A;  4FVK A;  5GTQ A;  1X2J A;  1NCB N;  4GZT A;  1W8N A;  4XJZ A;  1Z4X A;  1CVM A;  3A72 A;  4QN7 A;  4XOG A;  3O9J A;  4GNC A;  4GN7 A;  1NN2 A;  2QWG A;  2F0Z A;  2Z32 A;  4Q1U A;  5GX5 A;  2H2N A;  1WCS A;  4L7B A;  7NN9 A;  1IVC A;  1RWL A;  1N1S A;  4QN3 A;  4YW5 A;  3KYA A;  4XIL A;  4GDI A;  3A9H A;  2F27 A;  2HTU A;  4IN4 A;  1NMB N;  4MWX A;  3FW0 A;  5GX2 A;  4YW2 A;  2ZB6 A;  4XE9 A;  5JYY A;  2F12 A;  1MWE A;  2HT8 A;  1KIT A;  2JKB A;  3H72 A;  3P5B L;  1U6D X;  1Z4Z A;  2HT7 A;  1BJI A;  1NMA N;  4D52 B;  1SLI A;  4IMB A;  1A4G A;  1IVE A;  1EUU A;  1S1D A;  2IAQ A;  5FZJ A;  2FP8 A;  2YDT A;  4XJU A;  3SIL A;  2VVZ A;  3TC9 A;  4AGT A;  2YA4 A;  4HZZ A;  1ING A;  3WDZ A;  4MWY A;  2XN4 A;  4X49 A;  2AEP A;  4XJR A;  1Z4V A;  2QWB A;  4M4U A;  5FWW A;  4GNA A;  4WA3 A;  4GN9 A;  4CPN A;  1NCC N;  1OFZ A;  4GZO A;  2ISM A;  4FPY A;  2H2U A;  1C9U A;  3Q6P A;  1X2R A;  1XOE A;  3H6J A;  5HUN A;  2F29 A;  3TIB A;  1S0I A;  4BBW A;  5HUG A;  5D9D A;  2ZWA A;  2QWK A;  4FPH A;  2GVV A;  4XHB A;  4AH4 A;  4K1I A;  2W8B A;  3H71 A;  1A4Q A;  1VCU A;  2GVX A;  4QN5 A;  4FP3 A;  1USR A;  3SLI A;  3BYC A;  4B7J A;  3L6V A;  4MJU A;  3SAL A;  1IVB A;  1ZGK A;  3FVZ A;  2FPC A;  4FOY A;  4C1Y A;  4YZ3 A;  4JF7 A;  1CRZ A;  3VNH A;  4XMI A;  3LI3 A;  4D52 C;  5F72 C;  2VPJ A;  2VAQ A;  2VW1 A;  4FPL A;  3A9G A;  5M1Z A;  3OPZ A;  3GVK A;  2F13 A;  1Q7F A;  1NMC A;  5HUM A;  3S8V A;  3VNG A;  2F10 A;  4GB1 A;  2QWF A;  4AHA A;  1N6F A;  4YW4 A;  1MS3 A;  4DG6 A;  3LI4 A;  1F8B A;  5H47 A;  3SOQ A;  3SOB B;  2FHR A;  5EX7 A;  1DIL A;  3S8Z A;  2IAP A;  4FPK A;  4HIZ A;  4GNB A;  4UF7 A;  4J9T A;  5HX0 A;  1EUS A;  4IQK A;  3G4E A;  1L7G A;  1MZ6 A;  2DYH A;  2W8B B;  2QE8 A;  4MJV A;  4MWR A;  2VSK A;  2X9M A;  2BAT A;  3HLH A;  4FPJ A;  4KS1 A;  5B2C A;  3A71 A;  4HHQ A;  4IFN X;  4XIO A;  4YZ4 A;  3ALW A;  4CPY A;  1SLL A;  4X4A A;  4HZW A;  5FNQ A;  2BZD A;  4D4U A;  4QN4 A;  1MS0 A;  2HT5 A;  4MX0 A;  1INX A;  3V64 C;  4C1Y B;  1NNC A;  2C4L A;  4WEF A;  2RKC A;  3INB A;  1NSD A;  4KS5 A;  5GX1 A;  1N1Y A;  2HTQ A;  2QWI A;  4GN8 A;  1CRU A;  1V0F A;  3NO0 A;  1NSC A;  1MS8 A;  4WA5 A;  3WWA A;  4IFL X;  1IUB A;  2VW2 A;  4HZV A;  4WA4 A;  4XJW A;  4CPL A;  1S0J A;  2IAX A;  3BEQ A;  1B9T A;  1INY A;  2GVW A;  1V3E A;  3I1C A;  1W0O A;  5FNS A;  3GVJ A;  2QWH A;  4MWL A;  1L7H A;  4QN6 A;  2GVU A;  1Z4Y A;  2YDP A;  5CGJ A;  2DSO A;  2AH2 A;  1NCA N;  2HU0 A;  2VK7 A;  4K1K A;  4CPO A;  2F24 A;  3HRP A;  4X6K A;  4O5T A;  5HUK A;  3DAS A;  4KS2 A;  3S2K A;  2AGS A;  3WN7 A;  2IAV A;  4B7N A;  4MWV A;  4UOU A;  3CL2 A;  3W09 A;  1NCD N;  4ZY3 A;  1MZ5 A;  2VSM A;  4FOV A;  3ADE A;  4I00 A;  2HTY A;  3TI4 A;  1L7F A;  3AMS A;  1NPE A;  4H52 A;  1MR5 A;  1EUR A;  2CML A;  4PWZ A;  1INH A;  4K1H A;  1MS5 A;  2DG0 A;  1NSB A;  2XZJ A;  4FP2 A;  4D8S A;  4YW1 A;  4MWU A;  4X47 A;  1W20 A;  2QWA A;  1E8U A;  4XMA A;  2FLU X;  3JU4 A;  3KGG A;  1E8V A;  1MS9 A;  1XOG A;  2C4A A;  3B69 A;  2HQS A;  4GZS A;  4FZH A;  3WW9 A;  2IAU A;  2YA8 A;  3TIC A;  5F9T A;  2QWC A;  2IAR A;  2ZW9 A;  3K38 A;  2DG1 A;  1IVD A;  1EUT A;  4CSD A;  4FQ4 A;  4NCS A;  4FJ6 A;  2BF6 A;  1USX A;  2YA6 A;  4MZA A;  2W5N A;  3TI6 A;  3ZGC A;  2ZZK A;  4HHO A;  2IVZ A;  2G8S A;  3O9K A;  2FP9 A;  2SIM A;  4GZX A;  4CH9 A;  3CL0 A;  4K1J A;  4ASC A;  4YZ1 A;  1A14 N;  3V1S A;  3U0S A;  4YZ5 A;  4XMB A;  3IAX A;  3H73 A;  1V2I A;  5FNU A;  4XJ8 A;  3Q6T A;  3LI5 A;  2HTV A;  2V91 A;  4FPC A;  3TI8 A;  2VW0 A;  3PJQ A;  1POO A;  1VCJ A;  1DIM A;  1PJX A;  4GJT A;  2AEQ A;  1Z50 A;  2IAO A;  2XCY A;  1MS1 A;  2SLI A;  2IAT A;  4HZY A;  1NNB A;  1SNT A;  5D9C A;  2F11 A;  5FZN A;  1INV A;  5GX4 A;  4N1B A;  2WOZ A;  4WEG A;  1V3C A;  5FNT A;  2QWD A;  3NSS A;  4A0P A;  4GZW A;  4KS3 A;  1W1X A;  4GZQ A;  4XJA A;  3CYE A;  4NN9 A;  3SRE A;  4B7Q A;  4FOW A;  4CPM A;  1W21 A;  4MC7 A;  2A75 A;  1N7D A;  2IAS A;  4O5S A;  3CKZ A;  4M4V A;  4GEZ A;  1N6E A;  4XYX A;  1B9V A;  4K3Y A;  1W0P A;  2F26 A;  2W5O A;  4FPF A;  3SRG A;  1F8E A;  3V65 B;  3D12 A;  4YW3 A;  4FPO B;  2FPB A;  4XJQ A;  4XIK A;  1F8C A;  3T1E A;  4MZE A;  3O4P A;  4HW6 A;  4H53 A;  3HLI A;  4GDJ A;  4M4N A;  2BER A;  2F28 A;  5B2D A;  3SAN A;  5D9B A;  2IAW A;  4FPG A;  3D11 A;  4B7M A;  3K39 A;  3SOV A;  1MS4 A;  4MWQ A;  1C5K A; 
#chains in the Genus database with same CATH homology
 2ZWA A;  2XN4 A;  3ZGD A;  4IN4 A;  4ZY3 A;  4XMB A;  4N1B A;  1X2J A;  5FNQ A;  3ADE A;  2WOZ A;  2ZW9 A;  5F72 C;  4ZGC A;  2VPJ A;  5FNR A;  5FNU A;  5FNS A;  4L7D A;  5FNT A;  4CHB A;  4L7C A;  5CGJ A;  4YY8 A;  4IQK A;  1U6D X;  2DYH A;  3ZGC A;  3VNG A;  5FZJ A;  2ZZK A;  4IFJ A;  2Z32 A;  1X2R A;  3II7 A;  2FLU X;  4L7B A;  1ZGK A;  4CH9 A;  4IFL X;  4IFN X;  3WN7 A;  4ASC A;  3WDZ A;  5FZN A;  3VNH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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