4CHBA

Crystal structure of the human klhl2 kelch domain in complex with a wnk4 peptide
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
286
structure length
286
Chain Sequence
PKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDVASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
pubmed doi rcsb
molecule tags Signaling protein/transferase
source organism Homo sapiens
molecule keywords KELCH-LIKE PROTEIN 2
total genus 66
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4chbA00
3VNHA 1X2RA 1X2JA 4ZY3A 5F72C 1ZGKA 3WDZA 5CGJA 4IFNX 3ADEA 4ZGCA 5FNUA 4L7DA 4XMBA 4IQKA 3II7A 5FZNA 4L7BA 2ZW9A 5FNQA 4CHBA 2DYHA 5FNRA 2WOZA 3WN7A 4IFJA 4L7CA 5FNTA 1U6DX 4ASCA 4CH9A 5FZJA 2VPJA 2ZZKA 4IFLX 5FNSA 3VNGA 2ZWAA 3ZGCA 4YY8A 2XN4A 3ZGDA 2Z32A 4N1BA 4IN4A 2FLUX
chains in the Genus database with same CATH superfamily
4D4UA 1OFZA 2FPCA 1SUUA 2JKBA 3SANA 4GZSA 4HIZA 4FPYA 2QWDA 3GVLA 3H72A 2P4OA 3ADEA 4CPMA 4IQKA 1EURA 1MS8A 3TI6A 3V64C 1MZ6A 2XZJA 1IVFA 2HU4A 4YZ2A 2AGSA 1K32A 5HUGA 1IVCA 3S8VA 3LI3A 1SLIA 2VW0A 3SRGA 2DG1A 2HT7A 1Z4ZA 3TICA 1H6LA 4K3YA 2VW1A 2C4AA 1V3BA 1S18A 2HT5A 3TI4A 4GNBA 3I1CA 4FP2A 2HTYA 4GEZA 1C9UA 4CH9A 4KS3A 4XJQA 4YW3A 1KITA 3P5BL 1V0EA 2QWFA 5HUNA 3A9HA 2HU0A 2F29A 2BF6A 2SIMA 1WCSA 5CGJA 4IFNX 3PJQA 4XJRA 2FP9A 4MZAA 3II7A 1A4QA 3W09A 1USXA 2IAOA 1W20A 2HTWA 3E5ZA 1MS9A 4D8SA 2C4LA 4I00A 4QN4A 3WN7A 4MWVA 5EO7A 1W0OA 2VWDA 5GX1A 4MJUA 1NCCN 1Z50A 3B7EA 4R40A 4JF7A 1INWA 1CVMA 4K1KA 1V3DA 1Q7FA 4QN3A 4B7RA 4CPYA 3A9GA 2AEPA 4FOWA 1N7DA 1F8EA 4NCSA 1S1DA 4GZPA 4ZLRA 2GHSA 2IAWA 4AHAA 2QWEA 3HLHA 2QWAA 5GTQA 1IVGA 3ZGCA 2HTVA 4Q6KA 5GX2A 1N1YA 3ZGDA 2Z32A 1NPEA 2W20A 1IVBA 1N1VA 2W38A 4BBWA 3Q6TA 4K1JA 2IASA 5JYYA 1VCJA 4MWXA 4GN8A 4ZGCA 5FNUA 3TI3A 3NO0A 1Z4WA 4L7BA 4CSDA 2GVUA 1W8NA 1EUTA 1N1SA 2ISMA 2GVWA 1IJQA 4FPGA 2F25A 1USRA 3A72A 4FOYA 5D9BA 3B69A 3K39A 2F28A 1Z4VA 1X2JA 4XIKA 5HUMA 4ZY3A 5H47A 2VAQA 3TI5A 5M1ZA 3U0SA 2OJHA 4IYGA 1ZGKA 3WDZA 4AGTA 3DASA 2VK7A 2XZIA 4XIOA 4YZ5A 4GJTA 1W21A 4XJWA 2RKCA 2IARA 2W5NA 1N1TA 1MS1A 5FNTA 2F10A 2QWIA 3SILA 4YY8A 4XJ9A 1MR5A 4QN6A 4XILA 3VNHA 1X2RA 3S8ZA 3CL0A 3TIAA 5HX0A 1WCQA 1IVEA 1MS4A 3TC9A 1INHA 3WW9A 4D52B 1F8BA 1MS0A 3SALA 4CPNA 3SOBB 2DYHA 1EUSA 1E1AA 4B7MA 3BYCA 3V65B 3JU4A 1V0ZA 4D52A 4GB1A 2GVVA 4ASCA 1NMAN 3SOQA 2YA6A 4HHQA 1W1XA 2IAVA 1DIMA 2ZB5A 3L6VA 3S94A 1F8CA 4QN5A 4FPCA 3G4HA 4CPOA 2IAPA 4HZYA 2W5OA 2F11A 2VK6A 4GNAA 4DG6A 4XMIA 3SLIA 1CRUA 1S0IA 4WEGA 2ZW9A 4HW6A 1RWLA 1E8VA 2F26A 1NN2A 4GDJA 3D11A 2HQSA 4KS1A 3SOVA 4HZXA 4K1HA 2ZZKA 3Q6PA 1NCAN 1NCDN 4XJZA 4FQ4A 4N1BA 1NNBA 1V3CA 4FPJA 4IN4A 5B2CA 4FPHA 1NCBN 3SREA 3K3AA 4FPFA 2IATA 3AMSA 6NN9A 2QWBA 5HUKA 4C1YA 4XOGA 3GVJA 3K36A 2AH2A 3O9JA 4DGRA 2F27A 2VK5A 2YDPA 4X47A 4NC5A 1E8TA 1NMBN 1S0JA 1SLLA 2W8BB 2YA5A 4MWRA 4GZXA 1N6FA 4UF7A 1MS5A 1CQ1A 1N6EA 4YZ1A 1N6DA 4O5SA 4CPLA 2YDTA 3UC1A 2W8BA 2BATA 2F0ZA 2VVZA 4MWQA 3G4EA 4CHBA 4FZHA 2DG0A 1A4GA 1V0FA 2WOZA 1INGA 4GZWA 4YW4A 1INVA 4X49A 2F12A 3D12A 3A71A 5NN9A 2YA4A 1L7HA 2HTQA 1MS3A 3FW0A 1NNCA 4MX0A 2QWHA 4HZWA 1NNAA 4GN9A 4QN7A 1F8DA 2ZB6A 3ALXA 4GZTA 4L7DA 4XMBA 4NN9A 1QLGA 1QBIA 2FP8A 4KS2A 5F9TA 4XYXA 2XCYA 1MZ5A 4FPKA 1WP5A 4M3MA 1POOA 2A75A 1Z4YA 1U6DX 4HZVA 4H53A 2HTUA 4IFLX 4YZ3A 5FNSA 3OPZA 1PJXA 2V91A 1IUBA 4B7NA 1SO7A 4FPLA 1V3EA 2YA7A 4PWZA 1INYA 4MWWA 5D9CA 2IAXA 1B9TA 3K38A 1L7FA 3HRPA 4FOQA 5FNQA 5GX5A 5FNRA 3CKZA 1IUCA 4B7QA 4QNPA 3T1EA 4MZEA 4HZZA 4IFJA 4GDIA 5EO8A 4MWJA 3H71A 3FVZA 3GVKA 4A0PA 2BZDA 3H6JA 3DR2A 4XMAA 2CMLA 4YW5A 5B2DA 4JMLA 4AH4A 1NSBA 1Z4XA 4O5TA 4MJVA 3O9KA 5FWWA 4MC7A 2GVXA 4M4VA 4XJUA 1C5KA 5FZNA 3LI4A 1DILA 4CPZA 1E8UA 2QWGA 4Q1UA 5EX7A 1INXA 2FPBA 3NSSA 4XJ8A 1EUUA 5FZJA 3WWAA 2B8HA 3VNGA 2ZWAA 2VSMA 2XN4A 4M4UA 4C1YB 2QWJA 2FLUX 4YZ4A 4GN7A 2H2NA 4XJAA 5F72C 4IMBA 2BERA 2F13A 4XHXA 1NMCA 2QE8A 2G8SA 2SLIA 4WA4A 4MWUA 2IAQA 2X9MA 2HTRA 4J9TA 4G3NA 2VSKA 1B9SA 3CYEA 3TI8A 1A14N 4GZQA 4WA3A 2SILA 3ALWA 4M4NA 4D52C 2QWKA 7NN9A 4FPEA 4UOUA 4FP3A 2YA8A 3IAXA 1W0PA 1V2IA 2DSOA 4YW1A 3Q6KA 2IAUA 4GZOA 2IVZA 4FOVA 2QWCA 3KYAA 1RWIA 4H52A 4WEFA 5GX3A 1V04A 2XZKA 4X6KA 3INBA 4AGIA 1XOGA 2H2UA 1VCUA 3AMRA 4B7JA 3K37A 3HLIA 4FPOB 3S2KA 1CRZA 3LI5A 1SNTA 1B9VA 1BJIA 2VPJA 4XE9A 4YW2A 1ZI0A 1W8OA 4FVKA 5D9DA 3CL2A 1MWEA 4K1IA 4KS4A 1IVDA 1NSDA 1XOEA 3H73A 4MWLA 4GNCA 1INFA 4MWYA 4FJ6A 2F24A 4KS5A 5GX4A 1L7GA 2POOA 4WA5A 4SLIA 3O4PA 3V1SA 1NSCA 4L7CA 2VW2A 2HT8A 4HHOA 3BEQA 3NN9A 3KGGA 4XHBA 4X4AA 2FHRA 3TIBA 2AEQA
chains in the Genus database with same CATH topology
3VNHA 1X2RA 1X2JA 4ZY3A 5F72C 1ZGKA 3WDZA 5CGJA 4IFNX 3ADEA 4ZGCA 5FNUA 4L7DA 4XMBA 4IQKA 3II7A 5FZNA 4L7BA 2ZW9A 5FNQA 4CHBA 2DYHA 5FNRA 2WOZA 3WN7A 4IFJA 4L7CA 5FNTA 1U6DX 4ASCA 4CH9A 5FZJA 2VPJA 2ZZKA 4IFLX 5FNSA 3VNGA 2ZWAA 3ZGCA 4YY8A 2XN4A 3ZGDA 2Z32A 4N1BA 4IN4A 2FLUX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VNH A;  1X2R A;  1X2J A;  4ZY3 A;  5F72 C;  1ZGK A;  3WDZ A;  5CGJ A;  4IFN X;  3ADE A;  4ZGC A;  5FNU A;  4L7D A;  4XMB A;  4IQK A;  3II7 A;  5FZN A;  4L7B A;  2ZW9 A;  5FNQ A;  4CHB A;  2DYH A;  5FNR A;  2WOZ A;  3WN7 A;  4IFJ A;  4L7C A;  5FNT A;  1U6D X;  4ASC A;  4CH9 A;  5FZJ A;  2VPJ A;  2ZZK A;  4IFL X;  5FNS A;  3VNG A;  2ZWA A;  3ZGC A;  4YY8 A;  2XN4 A;  3ZGD A;  2Z32 A;  4N1B A;  4IN4 A;  2FLU X; 
#chains in the Genus database with same CATH topology
 4D4U A;  1OFZ A;  2FPC A;  1SUU A;  2JKB A;  3SAN A;  4GZS A;  4HIZ A;  4FPY A;  2QWD A;  3GVL A;  3H72 A;  2P4O A;  3ADE A;  4CPM A;  4IQK A;  1EUR A;  1MS8 A;  3TI6 A;  3V64 C;  1MZ6 A;  2XZJ A;  1IVF A;  2HU4 A;  4YZ2 A;  2AGS A;  1K32 A;  5HUG A;  1IVC A;  3S8V A;  3LI3 A;  1SLI A;  2VW0 A;  3SRG A;  2DG1 A;  2HT7 A;  1Z4Z A;  3TIC A;  1H6L A;  4K3Y A;  2VW1 A;  2C4A A;  1V3B A;  1S18 A;  2HT5 A;  3TI4 A;  4GNB A;  3I1C A;  4FP2 A;  2HTY A;  4GEZ A;  1C9U A;  4CH9 A;  4KS3 A;  4XJQ A;  4YW3 A;  1KIT A;  3P5B L;  1V0E A;  2QWF A;  5HUN A;  3A9H A;  2HU0 A;  2F29 A;  2BF6 A;  2SIM A;  1WCS A;  5CGJ A;  4IFN X;  3PJQ A;  4XJR A;  2FP9 A;  4MZA A;  3II7 A;  1A4Q A;  3W09 A;  1USX A;  2IAO A;  1W20 A;  2HTW A;  3E5Z A;  1MS9 A;  4D8S A;  2C4L A;  4I00 A;  4QN4 A;  3WN7 A;  4MWV A;  5EO7 A;  1W0O A;  2VWD A;  5GX1 A;  4MJU A;  1NCC N;  1Z50 A;  3B7E A;  4R40 A;  4JF7 A;  1INW A;  1CVM A;  4K1K A;  1V3D A;  1Q7F A;  4QN3 A;  4B7R A;  4CPY A;  3A9G A;  2AEP A;  4FOW A;  1N7D A;  1F8E A;  4NCS A;  1S1D A;  4GZP A;  4ZLR A;  2GHS A;  2IAW A;  4AHA A;  2QWE A;  3HLH A;  2QWA A;  5GTQ A;  1IVG A;  3ZGC A;  2HTV A;  4Q6K A;  5GX2 A;  1N1Y A;  3ZGD A;  2Z32 A;  1NPE A;  2W20 A;  1IVB A;  1N1V A;  2W38 A;  4BBW A;  3Q6T A;  4K1J A;  2IAS A;  5JYY A;  1VCJ A;  4MWX A;  4GN8 A;  4ZGC A;  5FNU A;  3TI3 A;  3NO0 A;  1Z4W A;  4L7B A;  4CSD A;  2GVU A;  1W8N A;  1EUT A;  1N1S A;  2ISM A;  2GVW A;  1IJQ A;  4FPG A;  2F25 A;  1USR A;  3A72 A;  4FOY A;  5D9B A;  3B69 A;  3K39 A;  2F28 A;  1Z4V A;  1X2J A;  4XIK A;  5HUM A;  4ZY3 A;  5H47 A;  2VAQ A;  3TI5 A;  5M1Z A;  3U0S A;  2OJH A;  4IYG A;  1ZGK A;  3WDZ A;  4AGT A;  3DAS A;  2VK7 A;  2XZI A;  4XIO A;  4YZ5 A;  4GJT A;  1W21 A;  4XJW A;  2RKC A;  2IAR A;  2W5N A;  1N1T A;  1MS1 A;  5FNT A;  2F10 A;  2QWI A;  3SIL A;  4YY8 A;  4XJ9 A;  1MR5 A;  4QN6 A;  4XIL A;  3VNH A;  1X2R A;  3S8Z A;  3CL0 A;  3TIA A;  5HX0 A;  1WCQ A;  1IVE A;  1MS4 A;  3TC9 A;  1INH A;  3WW9 A;  4D52 B;  1F8B A;  1MS0 A;  3SAL A;  4CPN A;  3SOB B;  2DYH A;  1EUS A;  1E1A A;  4B7M A;  3BYC A;  3V65 B;  3JU4 A;  1V0Z A;  4D52 A;  4GB1 A;  2GVV A;  4ASC A;  1NMA N;  3SOQ A;  2YA6 A;  4HHQ A;  1W1X A;  2IAV A;  1DIM A;  2ZB5 A;  3L6V A;  3S94 A;  1F8C A;  4QN5 A;  4FPC A;  3G4H A;  4CPO A;  2IAP A;  4HZY A;  2W5O A;  2F11 A;  2VK6 A;  4GNA A;  4DG6 A;  4XMI A;  3SLI A;  1CRU A;  1S0I A;  4WEG A;  2ZW9 A;  4HW6 A;  1RWL A;  1E8V A;  2F26 A;  1NN2 A;  4GDJ A;  3D11 A;  2HQS A;  4KS1 A;  3SOV A;  4HZX A;  4K1H A;  2ZZK A;  3Q6P A;  1NCA N;  1NCD N;  4XJZ A;  4FQ4 A;  4N1B A;  1NNB A;  1V3C A;  4FPJ A;  4IN4 A;  5B2C A;  4FPH A;  1NCB N;  3SRE A;  3K3A A;  4FPF A;  2IAT A;  3AMS A;  6NN9 A;  2QWB A;  5HUK A;  4C1Y A;  4XOG A;  3GVJ A;  3K36 A;  2AH2 A;  3O9J A;  4DGR A;  2F27 A;  2VK5 A;  2YDP A;  4X47 A;  4NC5 A;  1E8T A;  1NMB N;  1S0J A;  1SLL A;  2W8B B;  2YA5 A;  4MWR A;  4GZX A;  1N6F A;  4UF7 A;  1MS5 A;  1CQ1 A;  1N6E A;  4YZ1 A;  1N6D A;  4O5S A;  4CPL A;  2YDT A;  3UC1 A;  2W8B A;  2BAT A;  2F0Z A;  2VVZ A;  4MWQ A;  3G4E A;  4CHB A;  4FZH A;  2DG0 A;  1A4G A;  1V0F A;  2WOZ A;  1ING A;  4GZW A;  4YW4 A;  1INV A;  4X49 A;  2F12 A;  3D12 A;  3A71 A;  5NN9 A;  2YA4 A;  1L7H A;  2HTQ A;  1MS3 A;  3FW0 A;  1NNC A;  4MX0 A;  2QWH A;  4HZW A;  1NNA A;  4GN9 A;  4QN7 A;  1F8D A;  2ZB6 A;  3ALX A;  4GZT A;  4L7D A;  4XMB A;  4NN9 A;  1QLG A;  1QBI A;  2FP8 A;  4KS2 A;  5F9T A;  4XYX A;  2XCY A;  1MZ5 A;  4FPK A;  1WP5 A;  4M3M A;  1POO A;  2A75 A;  1Z4Y A;  1U6D X;  4HZV A;  4H53 A;  2HTU A;  4IFL X;  4YZ3 A;  5FNS A;  3OPZ A;  1PJX A;  2V91 A;  1IUB A;  4B7N A;  1SO7 A;  4FPL A;  1V3E A;  2YA7 A;  4PWZ A;  1INY A;  4MWW A;  5D9C A;  2IAX A;  1B9T A;  3K38 A;  1L7F A;  3HRP A;  4FOQ A;  5FNQ A;  5GX5 A;  5FNR A;  3CKZ A;  1IUC A;  4B7Q A;  4QNP A;  3T1E A;  4MZE A;  4HZZ A;  4IFJ A;  4GDI A;  5EO8 A;  4MWJ A;  3H71 A;  3FVZ A;  3GVK A;  4A0P A;  2BZD A;  3H6J A;  3DR2 A;  4XMA A;  2CML A;  4YW5 A;  5B2D A;  4JML A;  4AH4 A;  1NSB A;  1Z4X A;  4O5T A;  4MJV A;  3O9K A;  5FWW A;  4MC7 A;  2GVX A;  4M4V A;  4XJU A;  1C5K A;  5FZN A;  3LI4 A;  1DIL A;  4CPZ A;  1E8U A;  2QWG A;  4Q1U A;  5EX7 A;  1INX A;  2FPB A;  3NSS A;  4XJ8 A;  1EUU A;  5FZJ A;  3WWA A;  2B8H A;  3VNG A;  2ZWA A;  2VSM A;  2XN4 A;  4M4U A;  4C1Y B;  2QWJ A;  2FLU X;  4YZ4 A;  4GN7 A;  2H2N A;  4XJA A;  5F72 C;  4IMB A;  2BER A;  2F13 A;  4XHX A;  1NMC A;  2QE8 A;  2G8S A;  2SLI A;  4WA4 A;  4MWU A;  2IAQ A;  2X9M A;  2HTR A;  4J9T A;  4G3N A;  2VSK A;  1B9S A;  3CYE A;  3TI8 A;  1A14 N;  4GZQ A;  4WA3 A;  2SIL A;  3ALW A;  4M4N A;  4D52 C;  2QWK A;  7NN9 A;  4FPE A;  4UOU A;  4FP3 A;  2YA8 A;  3IAX A;  1W0P A;  1V2I A;  2DSO A;  4YW1 A;  3Q6K A;  2IAU A;  4GZO A;  2IVZ A;  4FOV A;  2QWC A;  3KYA A;  1RWI A;  4H52 A;  4WEF A;  5GX3 A;  1V04 A;  2XZK A;  4X6K A;  3INB A;  4AGI A;  1XOG A;  2H2U A;  1VCU A;  3AMR A;  4B7J A;  3K37 A;  3HLI A;  4FPO B;  3S2K A;  1CRZ A;  3LI5 A;  1SNT A;  1B9V A;  1BJI A;  2VPJ A;  4XE9 A;  4YW2 A;  1ZI0 A;  1W8O A;  4FVK A;  5D9D A;  3CL2 A;  1MWE A;  4K1I A;  4KS4 A;  1IVD A;  1NSD A;  1XOE A;  3H73 A;  4MWL A;  4GNC A;  1INF A;  4MWY A;  4FJ6 A;  2F24 A;  4KS5 A;  5GX4 A;  1L7G A;  2POO A;  4WA5 A;  4SLI A;  3O4P A;  3V1S A;  1NSC A;  4L7C A;  2VW2 A;  2HT8 A;  4HHO A;  3BEQ A;  3NN9 A;  3KGG A;  4XHB A;  4X4A A;  2FHR A;  3TIB A;  2AEQ A; 
#chains in the Genus database with same CATH homology
 3VNH A;  1X2R A;  1X2J A;  4ZY3 A;  5F72 C;  1ZGK A;  3WDZ A;  5CGJ A;  4IFN X;  3ADE A;  4ZGC A;  5FNU A;  4L7D A;  4XMB A;  4IQK A;  3II7 A;  5FZN A;  4L7B A;  2ZW9 A;  5FNQ A;  4CHB A;  2DYH A;  5FNR A;  2WOZ A;  3WN7 A;  4IFJ A;  4L7C A;  5FNT A;  1U6D X;  4ASC A;  4CH9 A;  5FZJ A;  2VPJ A;  2ZZK A;  4IFL X;  5FNS A;  3VNG A;  2ZWA A;  3ZGC A;  4YY8 A;  2XN4 A;  3ZGD A;  2Z32 A;  4N1B A;  4IN4 A;  2FLU X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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