4ZY3A

Crystal structure of keap1 in complex with a small chemical compound, k67
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
pubmed doi rcsb
molecule tags Transcription
source organism Mus musculus
molecule keywords Kelch-like ECH-associated protein 1
total genus 67
structure length 285
sequence length 285
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4zy3A00
2VPJA 3WDZA 4L7CA 1ZGKA 3II7A 4ASCA 2ZWAA 4IFNX 4IN4A 5FZNA 4ZY3A 2FLUX 2ZZKA 5F72C 3WN7A 2XN4A 2ZW9A 5FNUA 2DYHA 5FNTA 5FZJA 1X2JA 1X2RA 3ADEA 3ZGCA 3ZGDA 3VNHA 4CH9A 2WOZA 4L7BA 5FNRA 4XMBA 5FNSA 4CHBA 1U6DX 4ZGCA 4IFJA 5CGJA 4YY8A 4L7DA 2Z32A 4IQKA 3VNGA 4N1BA 4IFLX 5FNQA
chains in the Genus database with same CATH superfamily
2F10A 3NN9A 4FOVA 1EURA 4IFNX 1NNAA 4FPYA 4GB1A 4FQ4A 4FPCA 3O9KA 3FW0A 2W8BB 5GX5A 3TICA 2F26A 1NSDA 4ZLRA 2YA5A 4QN4A 4CPMA 1MS5A 3T1EA 1SUUA 4M4VA 2GVVA 3DR2A 4L7BA 4QN3A 5FNSA 3AMSA 4CHBA 4DGRA 4X4AA 3TI6A 3A72A 2FP9A 2QWBA 4GDIA 2BF6A 1SLLA 4GEZA 4WEGA 3SOVA 5CGJA 4D52B 4KS5A 2IAWA 2DG1A 5GX4A 1ZGKA 4ASCA 1V0EA 1MR5A 1K32A 1IVCA 1Z4YA 4MZEA 1E8UA 4B7QA 3INBA 2A75A 4MWYA 2ZW9A 1B9TA 4GDJA 4XHBA 4D4UA 2QWDA 3CYEA 4Q6KA 5EX7A 3B7EA 2QWEA 2VAQA 3H6JA 5HUMA 1NCBN 2IAPA 4YW1A 2POOA 2XCYA 4FP3A 2OJHA 2SILA 2XZJA 3S2KA 1NN2A 2F28A 1F8DA 5F9TA 3SANA 1USXA 2F27A 4QN7A 2W5OA 1X2JA 4XJWA 1V3DA 4WEFA 4HZXA 4GZWA 1E8TA 4HZVA 1INXA 4PWZA 1RWLA 2QWCA 4K1IA 3AMRA 2V91A 2Z32A 4XHXA 1C5KA 1NMCA 3JU4A 4GZOA 2VW1A 1L7GA 3KYAA 2VK6A 3II7A 1Q7FA 2BZDA 5EO8A 4WA4A 2HT5A 3LI5A 3CKZA 1W0OA 4XMIA 2QWIA 2ZB6A 1KITA 2YDPA 4X47A 4FP2A 3O9JA 1V0ZA 2DG0A 2H2NA 3TI8A 2YA7A 3A9GA 2VW0A 2BERA 4GZTA 1XOGA 5NN9A 2HTRA 1W0PA 4XJRA 1VCUA 4L7CA 4M4NA 4XJUA 4CPOA 4XJQA 4MWQA 3TI5A 4GN8A 3H72A 1N1VA 4MZAA 4M4UA 1VCJA 3PJQA 4GZQA 4XMBA 4XIKA 2W8BA 4YW4A 2AH2A 3D12A 1INHA 2IAQA 3H73A 2X9MA 4GZSA 5HX0A 4UF7A 4KS4A 2HT7A 4GNBA 1WCSA 4DG6A 4D52A 4X49A 1A14N 4FZHA 4FPHA 1W8OA 4FPFA 2RKCA 1NCAN 4I00A 4FJ6A 2YA4A 1USRA 2W5NA 3OPZA 5FNRA 4O5SA 4B7NA 1F8BA 5JYYA 3ALXA 4XMAA 4ZGCA 3L6VA 2G8SA 1N7DA 5FNQA 5B2CA 4HHQA 4MWUA 4XYXA 1W21A 3NO0A 4XJZA 4MWVA 4XJ8A 3WN7A 2QWFA 4FOWA 3TI3A 3A9HA 3S8ZA 3W09A 3ZGCA 3WW9A 4QNPA 4QN6A 3Q6TA 1V2IA 1WP5A 3HRPA 4J9TA 4FPLA 3ALWA 1IUCA 3SILA 4YY8A 4YZ1A 4X6KA 3HLHA 1OFZA 4XOGA 4IMBA 3SALA 2HTWA 1DIMA 2CMLA 4XE9A 2FLUX 2JKBA 4G3NA 2VW2A 4YZ2A 4CSDA 2YA6A 2GVXA 5FNTA 2YDTA 4H53A 5EO7A 1X2RA 1DILA 4NC5A 3NSSA 4CH9A 4FPGA 2WOZA 6NN9A 5GX1A 2GHSA 4NCSA 4FVKA 1N1TA 1IJQA 1SLIA 3CL2A 3K37A 3P5BL 1MS1A 4L7DA 3SRGA 4IQKA 2FPBA 4N1BA 4AH4A 1V0FA 1V3CA 4C1YB 1POOA 3FVZA 2F13A 5D9BA 3HLIA 1SO7A 3S8VA 1NSBA 4XJAA 3V65B 4GN9A 4GZPA 2HU0A 1S1DA 1NNBA 4GNAA 2YA8A 4HIZA 2XZIA 2VVZA 2W20A 1INFA 4HZYA 1MS0A 3UC1A 4B7MA 3A71A 1MS3A 1N6EA 2H2UA 2W38A 4UOUA 3SOBB 1BJIA 1NCCN 2ZZKA 4MX0A 3SLIA 4YZ5A 3GVJA 2SLIA 2FHRA 2QWAA 4YZ4A 1W8NA 1PJXA 2GVWA 3ADEA 1NNCA 5HUGA 1NPEA 1NCDN 2XZKA 4D52C 4WA5A 2AEPA 1F8EA 3G4EA 1N6FA 4AGTA 1MZ5A 3O4PA 5GTQA 2AGSA 3Q6KA 4GZXA 5FWWA 2IARA 2FPCA 2ZWAA 4IN4A 2FP8A 3S94A 1QLGA 4JMLA 2XN4A 4MWLA 2F29A 4CPZA 3D11A 2C4LA 4O5TA 2IAOA 4MC7A 2VSMA 5GX3A 4M3MA 1EUUA 1ZI0A 1EUTA 2IAVA 5M1ZA 1U6DX 4YW2A 3VNGA 1F8CA 3DASA 2HTVA 1IUBA 1INWA 1W20A 4AHAA 4K1KA 5GX2A 4IYGA 2IAXA 4FPKA 5F72C 3LI3A 3K3AA 1QBIA 4MWJA 4CPNA 1CQ1A 2VWDA 1INYA 2F24A 1Z4WA 4MWXA 1S18A 3G4HA 1SNTA 4B7RA 3U0SA 1Z4ZA 2P4OA 4Q1UA 1N1YA 1V04A 4WA3A 4A0PA 2ISMA 1S0IA 4SLIA 2BATA 1CRZA 2F25A 1A4GA 2HTQA 2QWJA 4FPOB 4K1HA 3B69A 3BEQA 1N6DA 4K1JA 1CRUA 4FPEA 3E5ZA 4QN5A 3K39A 1NSCA 3KGGA 1L7FA 4H52A 1H6LA 4C1YA 2HU4A 4GJTA 1IVEA 2IAUA 7NN9A 3SREA 1EUSA 4CPYA 1INGA 4R40A 4YZ3A 1WCQA 3GVLA 3TIAA 3H71A 2HT8A 1IVBA 1XOEA 2DSOA 4KS2A 4GNCA 1W1XA 2F0ZA 1E8VA 3WDZA 4FPJA 4MWRA 3I1CA 1S0JA 4MJUA 1IVDA 2F11A 2ZB5A 4JF7A 4AGIA 1Z4VA 4XILA 4FOYA 5FZJA 4KS1A 1V3BA 3CL0A 5H47A 4KS3A 2VK7A 1B9VA 2IVZA 1NMBN 3SOQA 1IVGA 1INVA 4CPLA 1V3EA 4XIOA 2QWGA 3TI4A 4IFLX 2HTYA 2IATA 2VPJA 4HHOA 3V1SA 3GVKA 2F12A 5D9CA 4HZZA 1MS8A 2IASA 1MS4A 1L7HA 2B8HA 2DYHA 2VK5A 4HW6A 2C4AA 4K3YA 4B7JA 3ZGDA 3VNHA 2QE8A 1E1AA 3V64C 3TC9A 4FOQA 1MS9A 3K38A 2QWHA 1NMAN 5HUKA 1MWEA 1N1SA 1MZ6A 1C9UA 5D9DA 1Z4XA 1IVFA 3Q6PA 4NN9A 4HZWA 3WWAA 1B9SA 1RWIA 4YW3A 4MJVA 4GN7A 5FZNA 4ZY3A 1A4QA 4D8SA 4XJ9A 5FNUA 2VSKA 3TIBA 1CVMA 2SIMA 2GVUA 3K36A 3IAXA 4YW5A 3BYCA 5HUNA 2HTUA 5B2DA 2QWKA 4MWWA 4IFJA 4BBWA 3LI4A 1Z50A 2AEQA 2HQSA
chains in the Genus database with same CATH topology
2VPJA 3WDZA 4L7CA 1ZGKA 3II7A 4ASCA 2ZWAA 4IFNX 4IN4A 5FZNA 4ZY3A 2FLUX 2ZZKA 5F72C 3WN7A 2XN4A 2ZW9A 5FNUA 2DYHA 5FNTA 5FZJA 1X2JA 1X2RA 3ADEA 3ZGCA 3ZGDA 3VNHA 4CH9A 2WOZA 4L7BA 5FNRA 4XMBA 5FNSA 4CHBA 1U6DX 4ZGCA 4IFJA 5CGJA 4YY8A 4L7DA 2Z32A 4IQKA 3VNGA 4N1BA 4IFLX 5FNQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VPJ A;  3WDZ A;  4L7C A;  1ZGK A;  3II7 A;  4ASC A;  2ZWA A;  4IFN X;  4IN4 A;  5FZN A;  4ZY3 A;  2FLU X;  2ZZK A;  5F72 C;  3WN7 A;  2XN4 A;  2ZW9 A;  5FNU A;  2DYH A;  5FNT A;  5FZJ A;  1X2J A;  1X2R A;  3ADE A;  3ZGC A;  3ZGD A;  3VNH A;  4CH9 A;  2WOZ A;  4L7B A;  5FNR A;  4XMB A;  5FNS A;  4CHB A;  1U6D X;  4ZGC A;  4IFJ A;  5CGJ A;  4YY8 A;  4L7D A;  2Z32 A;  4IQK A;  3VNG A;  4N1B A;  4IFL X;  5FNQ A; 
#chains in the Genus database with same CATH topology
 2F10 A;  3NN9 A;  4FOV A;  1EUR A;  4IFN X;  1NNA A;  4FPY A;  4GB1 A;  4FQ4 A;  4FPC A;  3O9K A;  3FW0 A;  2W8B B;  5GX5 A;  3TIC A;  2F26 A;  1NSD A;  4ZLR A;  2YA5 A;  4QN4 A;  4CPM A;  1MS5 A;  3T1E A;  1SUU A;  4M4V A;  2GVV A;  3DR2 A;  4L7B A;  4QN3 A;  5FNS A;  3AMS A;  4CHB A;  4DGR A;  4X4A A;  3TI6 A;  3A72 A;  2FP9 A;  2QWB A;  4GDI A;  2BF6 A;  1SLL A;  4GEZ A;  4WEG A;  3SOV A;  5CGJ A;  4D52 B;  4KS5 A;  2IAW A;  2DG1 A;  5GX4 A;  1ZGK A;  4ASC A;  1V0E A;  1MR5 A;  1K32 A;  1IVC A;  1Z4Y A;  4MZE A;  1E8U A;  4B7Q A;  3INB A;  2A75 A;  4MWY A;  2ZW9 A;  1B9T A;  4GDJ A;  4XHB A;  4D4U A;  2QWD A;  3CYE A;  4Q6K A;  5EX7 A;  3B7E A;  2QWE A;  2VAQ A;  3H6J A;  5HUM A;  1NCB N;  2IAP A;  4YW1 A;  2POO A;  2XCY A;  4FP3 A;  2OJH A;  2SIL A;  2XZJ A;  3S2K A;  1NN2 A;  2F28 A;  1F8D A;  5F9T A;  3SAN A;  1USX A;  2F27 A;  4QN7 A;  2W5O A;  1X2J A;  4XJW A;  1V3D A;  4WEF A;  4HZX A;  4GZW A;  1E8T A;  4HZV A;  1INX A;  4PWZ A;  1RWL A;  2QWC A;  4K1I A;  3AMR A;  2V91 A;  2Z32 A;  4XHX A;  1C5K A;  1NMC A;  3JU4 A;  4GZO A;  2VW1 A;  1L7G A;  3KYA A;  2VK6 A;  3II7 A;  1Q7F A;  2BZD A;  5EO8 A;  4WA4 A;  2HT5 A;  3LI5 A;  3CKZ A;  1W0O A;  4XMI A;  2QWI A;  2ZB6 A;  1KIT A;  2YDP A;  4X47 A;  4FP2 A;  3O9J A;  1V0Z A;  2DG0 A;  2H2N A;  3TI8 A;  2YA7 A;  3A9G A;  2VW0 A;  2BER A;  4GZT A;  1XOG A;  5NN9 A;  2HTR A;  1W0P A;  4XJR A;  1VCU A;  4L7C A;  4M4N A;  4XJU A;  4CPO A;  4XJQ A;  4MWQ A;  3TI5 A;  4GN8 A;  3H72 A;  1N1V A;  4MZA A;  4M4U A;  1VCJ A;  3PJQ A;  4GZQ A;  4XMB A;  4XIK A;  2W8B A;  4YW4 A;  2AH2 A;  3D12 A;  1INH A;  2IAQ A;  3H73 A;  2X9M A;  4GZS A;  5HX0 A;  4UF7 A;  4KS4 A;  2HT7 A;  4GNB A;  1WCS A;  4DG6 A;  4D52 A;  4X49 A;  1A14 N;  4FZH A;  4FPH A;  1W8O A;  4FPF A;  2RKC A;  1NCA N;  4I00 A;  4FJ6 A;  2YA4 A;  1USR A;  2W5N A;  3OPZ A;  5FNR A;  4O5S A;  4B7N A;  1F8B A;  5JYY A;  3ALX A;  4XMA A;  4ZGC A;  3L6V A;  2G8S A;  1N7D A;  5FNQ A;  5B2C A;  4HHQ A;  4MWU A;  4XYX A;  1W21 A;  3NO0 A;  4XJZ A;  4MWV A;  4XJ8 A;  3WN7 A;  2QWF A;  4FOW A;  3TI3 A;  3A9H A;  3S8Z A;  3W09 A;  3ZGC A;  3WW9 A;  4QNP A;  4QN6 A;  3Q6T A;  1V2I A;  1WP5 A;  3HRP A;  4J9T A;  4FPL A;  3ALW A;  1IUC A;  3SIL A;  4YY8 A;  4YZ1 A;  4X6K A;  3HLH A;  1OFZ A;  4XOG A;  4IMB A;  3SAL A;  2HTW A;  1DIM A;  2CML A;  4XE9 A;  2FLU X;  2JKB A;  4G3N A;  2VW2 A;  4YZ2 A;  4CSD A;  2YA6 A;  2GVX A;  5FNT A;  2YDT A;  4H53 A;  5EO7 A;  1X2R A;  1DIL A;  4NC5 A;  3NSS A;  4CH9 A;  4FPG A;  2WOZ A;  6NN9 A;  5GX1 A;  2GHS A;  4NCS A;  4FVK A;  1N1T A;  1IJQ A;  1SLI A;  3CL2 A;  3K37 A;  3P5B L;  1MS1 A;  4L7D A;  3SRG A;  4IQK A;  2FPB A;  4N1B A;  4AH4 A;  1V0F A;  1V3C A;  4C1Y B;  1POO A;  3FVZ A;  2F13 A;  5D9B A;  3HLI A;  1SO7 A;  3S8V A;  1NSB A;  4XJA A;  3V65 B;  4GN9 A;  4GZP A;  2HU0 A;  1S1D A;  1NNB A;  4GNA A;  2YA8 A;  4HIZ A;  2XZI A;  2VVZ A;  2W20 A;  1INF A;  4HZY A;  1MS0 A;  3UC1 A;  4B7M A;  3A71 A;  1MS3 A;  1N6E A;  2H2U A;  2W38 A;  4UOU A;  3SOB B;  1BJI A;  1NCC N;  2ZZK A;  4MX0 A;  3SLI A;  4YZ5 A;  3GVJ A;  2SLI A;  2FHR A;  2QWA A;  4YZ4 A;  1W8N A;  1PJX A;  2GVW A;  3ADE A;  1NNC A;  5HUG A;  1NPE A;  1NCD N;  2XZK A;  4D52 C;  4WA5 A;  2AEP A;  1F8E A;  3G4E A;  1N6F A;  4AGT A;  1MZ5 A;  3O4P A;  5GTQ A;  2AGS A;  3Q6K A;  4GZX A;  5FWW A;  2IAR A;  2FPC A;  2ZWA A;  4IN4 A;  2FP8 A;  3S94 A;  1QLG A;  4JML A;  2XN4 A;  4MWL A;  2F29 A;  4CPZ A;  3D11 A;  2C4L A;  4O5T A;  2IAO A;  4MC7 A;  2VSM A;  5GX3 A;  4M3M A;  1EUU A;  1ZI0 A;  1EUT A;  2IAV A;  5M1Z A;  1U6D X;  4YW2 A;  3VNG A;  1F8C A;  3DAS A;  2HTV A;  1IUB A;  1INW A;  1W20 A;  4AHA A;  4K1K A;  5GX2 A;  4IYG A;  2IAX A;  4FPK A;  5F72 C;  3LI3 A;  3K3A A;  1QBI A;  4MWJ A;  4CPN A;  1CQ1 A;  2VWD A;  1INY A;  2F24 A;  1Z4W A;  4MWX A;  1S18 A;  3G4H A;  1SNT A;  4B7R A;  3U0S A;  1Z4Z A;  2P4O A;  4Q1U A;  1N1Y A;  1V04 A;  4WA3 A;  4A0P A;  2ISM A;  1S0I A;  4SLI A;  2BAT A;  1CRZ A;  2F25 A;  1A4G A;  2HTQ A;  2QWJ A;  4FPO B;  4K1H A;  3B69 A;  3BEQ A;  1N6D A;  4K1J A;  1CRU A;  4FPE A;  3E5Z A;  4QN5 A;  3K39 A;  1NSC A;  3KGG A;  1L7F A;  4H52 A;  1H6L A;  4C1Y A;  2HU4 A;  4GJT A;  1IVE A;  2IAU A;  7NN9 A;  3SRE A;  1EUS A;  4CPY A;  1ING A;  4R40 A;  4YZ3 A;  1WCQ A;  3GVL A;  3TIA A;  3H71 A;  2HT8 A;  1IVB A;  1XOE A;  2DSO A;  4KS2 A;  4GNC A;  1W1X A;  2F0Z A;  1E8V A;  3WDZ A;  4FPJ A;  4MWR A;  3I1C A;  1S0J A;  4MJU A;  1IVD A;  2F11 A;  2ZB5 A;  4JF7 A;  4AGI A;  1Z4V A;  4XIL A;  4FOY A;  5FZJ A;  4KS1 A;  1V3B A;  3CL0 A;  5H47 A;  4KS3 A;  2VK7 A;  1B9V A;  2IVZ A;  1NMB N;  3SOQ A;  1IVG A;  1INV A;  4CPL A;  1V3E A;  4XIO A;  2QWG A;  3TI4 A;  4IFL X;  2HTY A;  2IAT A;  2VPJ A;  4HHO A;  3V1S A;  3GVK A;  2F12 A;  5D9C A;  4HZZ A;  1MS8 A;  2IAS A;  1MS4 A;  1L7H A;  2B8H A;  2DYH A;  2VK5 A;  4HW6 A;  2C4A A;  4K3Y A;  4B7J A;  3ZGD A;  3VNH A;  2QE8 A;  1E1A A;  3V64 C;  3TC9 A;  4FOQ A;  1MS9 A;  3K38 A;  2QWH A;  1NMA N;  5HUK A;  1MWE A;  1N1S A;  1MZ6 A;  1C9U A;  5D9D A;  1Z4X A;  1IVF A;  3Q6P A;  4NN9 A;  4HZW A;  3WWA A;  1B9S A;  1RWI A;  4YW3 A;  4MJV A;  4GN7 A;  5FZN A;  4ZY3 A;  1A4Q A;  4D8S A;  4XJ9 A;  5FNU A;  2VSK A;  3TIB A;  1CVM A;  2SIM A;  2GVU A;  3K36 A;  3IAX A;  4YW5 A;  3BYC A;  5HUN A;  2HTU A;  5B2D A;  2QWK A;  4MWW A;  4IFJ A;  4BBW A;  3LI4 A;  1Z50 A;  2AEQ A;  2HQS A; 
#chains in the Genus database with same CATH homology
 2VPJ A;  3WDZ A;  4L7C A;  1ZGK A;  3II7 A;  4ASC A;  2ZWA A;  4IFN X;  4IN4 A;  5FZN A;  4ZY3 A;  2FLU X;  2ZZK A;  5F72 C;  3WN7 A;  2XN4 A;  2ZW9 A;  5FNU A;  2DYH A;  5FNT A;  5FZJ A;  1X2J A;  1X2R A;  3ADE A;  3ZGC A;  3ZGD A;  3VNH A;  4CH9 A;  2WOZ A;  4L7B A;  5FNR A;  4XMB A;  5FNS A;  4CHB A;  1U6D X;  4ZGC A;  4IFJ A;  5CGJ A;  4YY8 A;  4L7D A;  2Z32 A;  4IQK A;  3VNG A;  4N1B A;  4IFL X;  5FNQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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