5CGJ | Genus

Total Genus 61

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	61
sequence length	290
structure length	290
Chain Sequence	VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Protein binding
source organism	Mus musculus
publication title	Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. pubmed doi rcsb
molecule keywords	Kelch-like ECH-associated protein 1
total genus	61
structure length	290
sequence length	290
ec nomenclature
pdb deposition date	2015-07-09

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01344	Kelch_1	Kelch motif

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	5cgjA00

5FNTA 5FNQA 3II7A 5FNUA 3VNGA 2ZW9A 1U6DX 2WOZA 4CHBA 1ZGKA 4IFJA 5CGJA 4ASCA 2Z32A 4XMBA 4L7DA 3WN7A 1X2JA 4IFLX 4ZY3A 3ADEA 4L7CA 3ZGDA 4N1BA 2DYHA 4IQKA 2ZWAA 1X2RA 3WDZA 3ZGCA 2XN4A 5FZNA 2ZZKA 4IFNX 4YY8A 3VNHA 5FNSA 2FLUX 2VPJA 5F72C 4L7BA 4IN4A 5FZJA 4ZGCA 5FNRA 4CH9A
chains in the Genus database with same CATH superfamily

2GHSA 3V65B 3II7A 2QWAA 2W8BB 5EX7A 3KYAA 3SOBB 6NN9A 2SILA 1Q7FA 1E1AA 2HT7A 2ISMA 7NN9A 4YZ5A 2VW0A 1NCDN 4MWUA 2F12A 2HTWA 2IAOA 1W21A 2VPJA 4FPGA 4FQ4A 4B7QA 4YZ4A 1E8VA 4MJUA 3CYEA 1IVCA 2IARA 3VNGA 4MWXA 3H72A 1ZGKA 4X47A 5D9DA 4X49A 4XMAA 3TICA 4FPYA 2IAQA 1N1YA 4FPLA 4UOUA 5HUGA 4FPEA 4FZHA 2ZB6A 2HT5A 2FP9A 1L7FA 5GX4A 1H6LA 4FPJA 2AEQA 3K37A 3NO0A 2XZJA 4FP2A 3BEQA 1MS5A 4FPOB 3V1SA 1V2IA 5FNQA 2FHRA 2VAQA 3K36A 4FJ6A 3GVJA 3T1EA 3L6VA 4MWWA 1F8DA 4AGIA 3H73A 4MX0A 2IAUA 3WN7A 2QWHA 2F0ZA 2HTYA 4WEGA 4GN7A 4YZ3A 3SLIA 1SNTA 4IQKA 2W5OA 3WDZA 1S0IA 4UF7A 1MS4A 1POOA 4GJTA 3NN9A 2IAVA 4MZEA 1MS0A 1N6DA 4IFJA 4FP3A 1B9SA 3O9KA 1IJQA 5HX0A 5B2DA 3S8VA 3SANA 1DIMA 1C9UA 1CRZA 3B69A 4GNCA 2GVVA 1V0ZA 1NCBN 3A9HA 1NSBA 1MS1A 4WA3A 1MZ6A 4YW3A 4XHXA 1NPEA 4JF7A 4IFNX 1W0OA 2XZKA 4XIOA 4XJUA 5FZJA 2BATA 4XE9A 1V3BA 4GZPA 4FPFA 4K1KA 4K3YA 4XIKA 4FOQA 4G3NA 4HHOA 5EO7A 2ZW9A 4CPLA 4FPKA 1NN2A 2XZIA 3UC1A 4XILA 4XMBA 1NSCA 4HIZA 1Z4WA 5HUNA 3INBA 2AGSA 1EUSA 1IVFA 5FNSA 1IUCA 4O5TA 4YZ1A 2CMLA 2W8BA 4YW5A 4ZLRA 1NMBN 3FW0A 1BJIA 4YW4A 1RWIA 2YA8A 4B7JA 3SALA 3TI3A 1NNAA 4XYXA 3G4HA 4IFLX 4YW2A 5NN9A 2F28A 4I00A 1NNBA 1PJXA 2F25A 3P5BL 4KS3A 2A75A 5F72C 1VCJA 3CKZA 2VWDA 1IVGA 1EUUA 4YZ2A 2VK6A 4YW1A 5GX2A 2IASA 4XJWA 3TIAA 2F24A 3LI3A 5GX5A 2QWCA 3K3AA 1N7DA 2BZDA 4GNBA 3Q6PA 3O9JA 2AEPA 2F13A 2QWJA 4MWQA 4SLIA 4A0PA 1INXA 1Z50A 2OJHA 3SOQA 1SUUA 2DG1A 1Z4VA 4FPCA 2V91A 1XOGA 2IVZA 3GVKA 4CHBA 4CPOA 4GN8A 3H6JA 5CGJA 2QWEA 2IAPA 2H2NA 1INVA 4H52A 4D8SA 1A4QA 1EUTA 1A14N 1V04A 2POOA 1W8OA 4O5SA 1MS8A 2IATA 2ZZKA 1NMAN 1WCSA 4NC5A 1W20A 1S18A 5H47A 4B7RA 5HUKA 1DILA 2VK5A 2C4AA 3PJQA 1U6DX 1V3CA 2WOZA 4H53A 1IVBA 2QWKA 1WCQA 4D52B 2VSKA 2F26A 4CPNA 2HQSA 3HLHA 4WA4A 4MWJA 1IVDA 2AH2A 1IVEA 1NSDA 4MWLA 2C4LA 1W1XA 2W38A 4KS2A 1SLLA 5EO8A 1L7HA 2YA4A 1INHA 2HTVA 2GVWA 1NMCA 2F27A 1B9VA 1X2JA 2HU0A 3ADEA 4L7CA 4GZWA 2VSMA 3ZGDA 2YA7A 3G4EA 3B7EA 1MZ5A 1NCCN 3DR2A 5GTQA 3SRGA 4HZWA 4FOVA 2ZB5A 3A71A 2QWBA 1CRUA 4NN9A 1N1SA 1F8CA 1Z4ZA 1C5KA 3ALXA 5FNRA 3Q6KA 4MC7A 2FP8A 1SLIA 2VW1A 3LI5A 3WW9A 4J9TA 3S2KA 2BF6A 5FNUA 2QWDA 2VW2A 3HLIA 4XJZA 4FOWA 1W8NA 3SOVA 3CL0A 4GDJA 2HU4A 5HUMA 3NSSA 2F29A 1INFA 1E8TA 3H71A 2YDPA 4AH4A 2QWIA 2VK7A 2ZWAA 5GX3A 2P4OA 2VVZA 3ALWA 5FZNA 1Z4YA 4GZTA 2FLUX 3V64C 5B2CA 2QE8A 3BYCA 4CPYA 4CSDA 2YDTA 4Q6KA 2HTUA 1MS9A 2XCYA 1S0JA 4QNPA 1V3EA 2IAWA 1IUBA 4FOYA 1MWEA 1XOEA 4ZY3A 5M1ZA 1V0FA 1V0EA 5FWWA 5GX1A 2DYHA 4M4NA 4HHQA 4QN7A 5D9BA 4AHAA 3SREA 4MZAA 4HZXA 4GZQA 1CVMA 1RWLA 4XOGA 4GB1A 1F8EA 2DSOA 3LI4A 1L7GA 1USRA 3SILA 1A4GA 4C1YA 1N1TA 2FPCA 1MR5A 4GDIA 2QWFA 1INWA 2HTRA 1SO7A 3K39A 4C1YB 3IAXA 4B7NA 2SIMA 1Z4XA 3E5ZA 4M4VA 4GNAA 3DASA 4D4UA 4KS5A 2DG0A 1MS3A 2H2UA 5F9TA 1USXA 3A9GA 4CPZA 3TIBA 1V3DA 4QN6A 2RKCA 4GZOA 2SLIA 2BERA 2F11A 1VCUA 1QLGA 3A72A 4ZGCA 4CPMA 4Q1UA 2GVUA 1K32A 3TI8A 3AMSA 5FNTA 3TI5A 4QN5A 1N1VA 4GEZA 2FPBA 4M4UA 4QN4A 2GVXA 4AGTA 4D52A 4D52C 4WEFA 2Z32A 2HT8A 4NCSA 3WWAA 3JU4A 5JYYA 3K38A 3I1CA 5D9CA 4XJAA 4XJ9A 3S94A 3TI6A 3ZGCA 2JKBA 4WA5A 4XJQA 4L7BA 4IN4A 3TC9A 4FVKA 4HZVA 2X9MA 3Q6TA 4MJVA 3OPZA 4CH9A 1INGA 2W5NA 4K1IA 2YA6A 4MWYA 4M3MA 4QN3A 4DGRA 1KITA 1B9TA 1N6FA 4HZZA 4PWZA 3FVZA 4GZXA 4BBWA 3AMRA 3O4PA 4MWRA 3TI4A 4B7MA 4HW6A 1F8BA 1NCAN 4YY8A 4HZYA 1NNCA 3GVLA 3S8ZA 1CQ1A 2B8HA 3VNHA 1S1DA 3U0SA 3D12A 4X6KA 2IAXA 4IYGA 1ZI0A 4IMBA 2YA5A 1W0PA 1N6EA 4MWVA 4KS1A 3HRPA 3D11A 4X4AA 4XJ8A 2G8SA 3W09A 4ASCA 4K1JA 4DG6A 1EURA 4K1HA 4L7DA 2QWGA 4GZSA 4XMIA 1WP5A 4JMLA 4N1BA 3KGGA 4R40A 1OFZA 4XJRA 1E8UA 1X2RA 2XN4A 2W20A 4FPHA 4XHBA 4KS4A 4GN9A 2F10A 1QBIA 3CL2A 1INYA 2HTQA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 5FNT A;  5FNQ A;  3II7 A;  5FNU A;  3VNG A;  2ZW9 A;  1U6D X;  2WOZ A;  4CHB A;  1ZGK A;  4IFJ A;  5CGJ A;  4ASC A;  2Z32 A;  4XMB A;  4L7D A;  3WN7 A;  1X2J A;  4IFL X;  4ZY3 A;  3ADE A;  4L7C A;  3ZGD A;  4N1B A;  2DYH A;  4IQK A;  2ZWA A;  1X2R A;  3WDZ A;  3ZGC A;  2XN4 A;  5FZN A;  2ZZK A;  4IFN X;  4YY8 A;  3VNH A;  5FNS A;  2FLU X;  2VPJ A;  5F72 C;  4L7B A;  4IN4 A;  5FZJ A;  4ZGC A;  5FNR A;  4CH9 A; 
#chains in the Genus database with same CATH topology
 2GHS A;  3V65 B;  3II7 A;  2QWA A;  2W8B B;  5EX7 A;  3KYA A;  3SOB B;  6NN9 A;  2SIL A;  1Q7F A;  1E1A A;  2HT7 A;  2ISM A;  7NN9 A;  4YZ5 A;  2VW0 A;  1NCD N;  4MWU A;  2F12 A;  2HTW A;  2IAO A;  1W21 A;  2VPJ A;  4FPG A;  4FQ4 A;  4B7Q A;  4YZ4 A;  1E8V A;  4MJU A;  3CYE A;  1IVC A;  2IAR A;  3VNG A;  4MWX A;  3H72 A;  1ZGK A;  4X47 A;  5D9D A;  4X49 A;  4XMA A;  3TIC A;  4FPY A;  2IAQ A;  1N1Y A;  4FPL A;  4UOU A;  5HUG A;  4FPE A;  4FZH A;  2ZB6 A;  2HT5 A;  2FP9 A;  1L7F A;  5GX4 A;  1H6L A;  4FPJ A;  2AEQ A;  3K37 A;  3NO0 A;  2XZJ A;  4FP2 A;  3BEQ A;  1MS5 A;  4FPO B;  3V1S A;  1V2I A;  5FNQ A;  2FHR A;  2VAQ A;  3K36 A;  4FJ6 A;  3GVJ A;  3T1E A;  3L6V A;  4MWW A;  1F8D A;  4AGI A;  3H73 A;  4MX0 A;  2IAU A;  3WN7 A;  2QWH A;  2F0Z A;  2HTY A;  4WEG A;  4GN7 A;  4YZ3 A;  3SLI A;  1SNT A;  4IQK A;  2W5O A;  3WDZ A;  1S0I A;  4UF7 A;  1MS4 A;  1POO A;  4GJT A;  3NN9 A;  2IAV A;  4MZE A;  1MS0 A;  1N6D A;  4IFJ A;  4FP3 A;  1B9S A;  3O9K A;  1IJQ A;  5HX0 A;  5B2D A;  3S8V A;  3SAN A;  1DIM A;  1C9U A;  1CRZ A;  3B69 A;  4GNC A;  2GVV A;  1V0Z A;  1NCB N;  3A9H A;  1NSB A;  1MS1 A;  4WA3 A;  1MZ6 A;  4YW3 A;  4XHX A;  1NPE A;  4JF7 A;  4IFN X;  1W0O A;  2XZK A;  4XIO A;  4XJU A;  5FZJ A;  2BAT A;  4XE9 A;  1V3B A;  4GZP A;  4FPF A;  4K1K A;  4K3Y A;  4XIK A;  4FOQ A;  4G3N A;  4HHO A;  5EO7 A;  2ZW9 A;  4CPL A;  4FPK A;  1NN2 A;  2XZI A;  3UC1 A;  4XIL A;  4XMB A;  1NSC A;  4HIZ A;  1Z4W A;  5HUN A;  3INB A;  2AGS A;  1EUS A;  1IVF A;  5FNS A;  1IUC A;  4O5T A;  4YZ1 A;  2CML A;  2W8B A;  4YW5 A;  4ZLR A;  1NMB N;  3FW0 A;  1BJI A;  4YW4 A;  1RWI A;  2YA8 A;  4B7J A;  3SAL A;  3TI3 A;  1NNA A;  4XYX A;  3G4H A;  4IFL X;  4YW2 A;  5NN9 A;  2F28 A;  4I00 A;  1NNB A;  1PJX A;  2F25 A;  3P5B L;  4KS3 A;  2A75 A;  5F72 C;  1VCJ A;  3CKZ A;  2VWD A;  1IVG A;  1EUU A;  4YZ2 A;  2VK6 A;  4YW1 A;  5GX2 A;  2IAS A;  4XJW A;  3TIA A;  2F24 A;  3LI3 A;  5GX5 A;  2QWC A;  3K3A A;  1N7D A;  2BZD A;  4GNB A;  3Q6P A;  3O9J A;  2AEP A;  2F13 A;  2QWJ A;  4MWQ A;  4SLI A;  4A0P A;  1INX A;  1Z50 A;  2OJH A;  3SOQ A;  1SUU A;  2DG1 A;  1Z4V A;  4FPC A;  2V91 A;  1XOG A;  2IVZ A;  3GVK A;  4CHB A;  4CPO A;  4GN8 A;  3H6J A;  5CGJ A;  2QWE A;  2IAP A;  2H2N A;  1INV A;  4H52 A;  4D8S A;  1A4Q A;  1EUT A;  1A14 N;  1V04 A;  2POO A;  1W8O A;  4O5S A;  1MS8 A;  2IAT A;  2ZZK A;  1NMA N;  1WCS A;  4NC5 A;  1W20 A;  1S18 A;  5H47 A;  4B7R A;  5HUK A;  1DIL A;  2VK5 A;  2C4A A;  3PJQ A;  1U6D X;  1V3C A;  2WOZ A;  4H53 A;  1IVB A;  2QWK A;  1WCQ A;  4D52 B;  2VSK A;  2F26 A;  4CPN A;  2HQS A;  3HLH A;  4WA4 A;  4MWJ A;  1IVD A;  2AH2 A;  1IVE A;  1NSD A;  4MWL A;  2C4L A;  1W1X A;  2W38 A;  4KS2 A;  1SLL A;  5EO8 A;  1L7H A;  2YA4 A;  1INH A;  2HTV A;  2GVW A;  1NMC A;  2F27 A;  1B9V A;  1X2J A;  2HU0 A;  3ADE A;  4L7C A;  4GZW A;  2VSM A;  3ZGD A;  2YA7 A;  3G4E A;  3B7E A;  1MZ5 A;  1NCC N;  3DR2 A;  5GTQ A;  3SRG A;  4HZW A;  4FOV A;  2ZB5 A;  3A71 A;  2QWB A;  1CRU A;  4NN9 A;  1N1S A;  1F8C A;  1Z4Z A;  1C5K A;  3ALX A;  5FNR A;  3Q6K A;  4MC7 A;  2FP8 A;  1SLI A;  2VW1 A;  3LI5 A;  3WW9 A;  4J9T A;  3S2K A;  2BF6 A;  5FNU A;  2QWD A;  2VW2 A;  3HLI A;  4XJZ A;  4FOW A;  1W8N A;  3SOV A;  3CL0 A;  4GDJ A;  2HU4 A;  5HUM A;  3NSS A;  2F29 A;  1INF A;  1E8T A;  3H71 A;  2YDP A;  4AH4 A;  2QWI A;  2VK7 A;  2ZWA A;  5GX3 A;  2P4O A;  2VVZ A;  3ALW A;  5FZN A;  1Z4Y A;  4GZT A;  2FLU X;  3V64 C;  5B2C A;  2QE8 A;  3BYC A;  4CPY A;  4CSD A;  2YDT A;  4Q6K A;  2HTU A;  1MS9 A;  2XCY A;  1S0J A;  4QNP A;  1V3E A;  2IAW A;  1IUB A;  4FOY A;  1MWE A;  1XOE A;  4ZY3 A;  5M1Z A;  1V0F A;  1V0E A;  5FWW A;  5GX1 A;  2DYH A;  4M4N A;  4HHQ A;  4QN7 A;  5D9B A;  4AHA A;  3SRE A;  4MZA A;  4HZX A;  4GZQ A;  1CVM A;  1RWL A;  4XOG A;  4GB1 A;  1F8E A;  2DSO A;  3LI4 A;  1L7G A;  1USR A;  3SIL A;  1A4G A;  4C1Y A;  1N1T A;  2FPC A;  1MR5 A;  4GDI A;  2QWF A;  1INW A;  2HTR A;  1SO7 A;  3K39 A;  4C1Y B;  3IAX A;  4B7N A;  2SIM A;  1Z4X A;  3E5Z A;  4M4V A;  4GNA A;  3DAS A;  4D4U A;  4KS5 A;  2DG0 A;  1MS3 A;  2H2U A;  5F9T A;  1USX A;  3A9G A;  4CPZ A;  3TIB A;  1V3D A;  4QN6 A;  2RKC A;  4GZO A;  2SLI A;  2BER A;  2F11 A;  1VCU A;  1QLG A;  3A72 A;  4ZGC A;  4CPM A;  4Q1U A;  2GVU A;  1K32 A;  3TI8 A;  3AMS A;  5FNT A;  3TI5 A;  4QN5 A;  1N1V A;  4GEZ A;  2FPB A;  4M4U A;  4QN4 A;  2GVX A;  4AGT A;  4D52 A;  4D52 C;  4WEF A;  2Z32 A;  2HT8 A;  4NCS A;  3WWA A;  3JU4 A;  5JYY A;  3K38 A;  3I1C A;  5D9C A;  4XJA A;  4XJ9 A;  3S94 A;  3TI6 A;  3ZGC A;  2JKB A;  4WA5 A;  4XJQ A;  4L7B A;  4IN4 A;  3TC9 A;  4FVK A;  4HZV A;  2X9M A;  3Q6T A;  4MJV A;  3OPZ A;  4CH9 A;  1ING A;  2W5N A;  4K1I A;  2YA6 A;  4MWY A;  4M3M A;  4QN3 A;  4DGR A;  1KIT A;  1B9T A;  1N6F A;  4HZZ A;  4PWZ A;  3FVZ A;  4GZX A;  4BBW A;  3AMR A;  3O4P A;  4MWR A;  3TI4 A;  4B7M A;  4HW6 A;  1F8B A;  1NCA N;  4YY8 A;  4HZY A;  1NNC A;  3GVL A;  3S8Z A;  1CQ1 A;  2B8H A;  3VNH A;  1S1D A;  3U0S A;  3D12 A;  4X6K A;  2IAX A;  4IYG A;  1ZI0 A;  4IMB A;  2YA5 A;  1W0P A;  1N6E A;  4MWV A;  4KS1 A;  3HRP A;  3D11 A;  4X4A A;  4XJ8 A;  2G8S A;  3W09 A;  4ASC A;  4K1J A;  4DG6 A;  1EUR A;  4K1H A;  4L7D A;  2QWG A;  4GZS A;  4XMI A;  1WP5 A;  4JML A;  4N1B A;  3KGG A;  4R40 A;  1OFZ A;  4XJR A;  1E8U A;  1X2R A;  2XN4 A;  2W20 A;  4FPH A;  4XHB A;  4KS4 A;  4GN9 A;  2F10 A;  1QBI A;  3CL2 A;  1INY A;  2HTQ A; 
#chains in the Genus database with same CATH homology
 5FNT A;  5FNQ A;  3II7 A;  5FNU A;  3VNG A;  2ZW9 A;  1U6D X;  2WOZ A;  4CHB A;  1ZGK A;  4IFJ A;  5CGJ A;  4ASC A;  2Z32 A;  4XMB A;  4L7D A;  3WN7 A;  1X2J A;  4IFL X;  4ZY3 A;  3ADE A;  4L7C A;  3ZGD A;  4N1B A;  2DYH A;  4IQK A;  2ZWA A;  1X2R A;  3WDZ A;  3ZGC A;  2XN4 A;  5FZN A;  2ZZK A;  4IFN X;  4YY8 A;  3VNH A;  5FNS A;  2FLU X;  2VPJ A;  5F72 C;  4L7B A;  4IN4 A;  5FZJ A;  4ZGC A;  5FNR A;  4CH9 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

5CGJA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations