5F72C

De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Total Genus 62

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYO1 (22-96)O2 (44-241)Updating...
connected with : NaN
molecule tags De novo protein
source organism Homo sapiens
publication title De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 62
structure length 285
sequence length 285
chains with identical sequence K
ec nomenclature
pdb deposition date 2015-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5f72C00
3VNHA 2VPJA 4IFLX 1U6DX 3WN7A 4CHBA 5FNQA 5FNTA 2DYHA 4CH9A 4N1BA 3ADEA 2ZW9A 1X2JA 4L7BA 4YY8A 4IQKA 4L7DA 5FNSA 1ZGKA 3ZGDA 4IFJA 5FNUA 3VNGA 4ZY3A 2WOZA 2XN4A 4ASCA 5F72C 5CGJA 1X2RA 2ZZKA 5FZJA 4ZGCA 3II7A 2ZWAA 4IN4A 4IFNX 2Z32A 3ZGCA 5FNRA 3WDZA 4L7CA 2FLUX 4XMBA 5FZNA
chains in the Genus database with same CATH superfamily
1N1YA 5HUMA 4X6KA 4KS3A 2QWGA 4O5TA 1F8CA 2VSKA 4YY8A 3V64C 5GX4A 3ZGDA 1CRUA 4GZTA 2C4AA 2VK6A 4CPZA 4XIOA 4JMLA 2GHSA 4G3NA 4FP2A 1VCUA 2IAOA 4ZLRA 4FPEA 3V1SA 4H53A 2IAWA 1WCSA 3K38A 4M4NA 2W20A 2HTUA 4FZHA 3CKZA 4QN4A 4FPYA 1NSBA 2DG0A 4HW6A 3A9GA 4KS5A 1INWA 2F0ZA 2VW0A 3SRGA 1W21A 2QE8A 1VCJA 3O9KA 4I00A 3P5BL 4DGRA 1SLIA 2AGSA 2SLIA 1NCCN 2Z32A 1INYA 5GX2A 3SREA 1NCAN 2YA6A 3VNHA 3ALWA 3TI8A 1B9SA 1A14N 4X4AA 4NC5A 3ADEA 1MS1A 3H6JA 4YZ3A 4H52A 3L6VA 1L7GA 1V2IA 1ZGKA 4CPLA 3SILA 1NN2A 4UF7A 1XOGA 2YDTA 4K1JA 1INFA 2F12A 4K1IA 3BYCA 4XOGA 1CVMA 5M1ZA 1PJXA 2F25A 4GN7A 1Z4ZA 3II7A 2HT7A 4SLIA 4MWVA 2F29A 2IAPA 3U0SA 3ZGCA 2AEPA 4XJAA 4K3YA 4L7CA 3LI5A 3GVKA 2P4OA 3WN7A 5D9BA 5FNQA 5FNTA 2HTVA 4GNBA 4CPMA 4HZXA 1Q7FA 1W0OA 3D12A 5HUNA 3K37A 4B7MA 1NCBN 1NNAA 2FP9A 4XJZA 1B9TA 1MWEA 2HQSA 3TI5A 5H47A 4GZPA 5GTQA 3S94A 3SLIA 2IATA 5EO7A 1S0JA 1X2RA 4XJ8A 4C1YA 2YA5A 2IARA 4HHOA 1E1AA 4XILA 2QWEA 4XHXA 2GVXA 3NO0A 2C4LA 2YA4A 4M4UA 2W5OA 4MX0A 1V04A 2HT5A 4FOYA 1IJQA 4FVKA 4XJ9A 3H71A 1V3CA 1X2JA 4L7BA 2FPCA 1EURA 1W0PA 1F8BA 1MS4A 3GVJA 2FP8A 1MS3A 4D4UA 5F72C 1BJIA 5FZJA 4K1HA 3E5ZA 4B7NA 2AH2A 3LI3A 4GNCA 3TI6A 2F24A 2ZB6A 4XIKA 6NN9A 4XYXA 4MWYA 5HX0A 2JKBA 4MWLA 2W38A 3TC9A 3SANA 4FPHA 4IQKA 3AMSA 3LI4A 4XJUA 1W1XA 5GX5A 1K32A 1W20A 1W8NA 4QN6A 3TIAA 4GDIA 4AH4A 4NN9A 4AGIA 1N6FA 3D11A 2HTWA 3HRPA 5EO8A 4FPCA 3O9JA 4GZWA 2GVWA 4IMBA 1CQ1A 4YW1A 4NCSA 1U6DX 4MZEA 1F8DA 3S8ZA 4GDJA 1E8UA 4FQ4A 3JU4A 1NMCA 2VW1A 4MWUA 2IAVA 3WWAA 1S1DA 4PWZA 4HIZA 4WA3A 1NPEA 1N7DA 2HT8A 4CSDA 4DG6A 3TI3A 1MS0A 2G8SA 3CL2A 3PJQA 3TIBA 2XN4A 1EUTA 1L7FA 4KS2A 3TICA 4MC7A 4B7RA 4WA5A 1V0EA 1V0ZA 4YW4A 3FVZA 4B7QA 2XCYA 2VPJA 4Q6KA 2IAXA 3H73A 4GZQA 1Z4YA 4AHAA 4D52B 4GZSA 2ISMA 1Z4VA 3UC1A 2W8BB 1V3EA 3CL0A 4GNAA 4CPNA 2IASA 4UOUA 2F11A 2XZKA 1NNBA 2IVZA 4A0PA 1DIMA 1QBIA 1A4QA 2POOA 5NN9A 3W09A 3Q6TA 2VWDA 3ALXA 3WDZA 1NSCA 3B7EA 1C5KA 1MS8A 3Q6PA 4HHQA 3OPZA 1IUBA 4MJUA 1INGA 4Q1UA 5F9TA 3DR2A 1MR5A 3B69A 2VK5A 5FNUA 5GX3A 1H6LA 1EUUA 4IYGA 1POOA 3WW9A 5D9CA 3I1CA 2XZIA 1DILA 4FJ6A 4YZ4A 4R40A 2F26A 4XMIA 2SILA 1IUCA 1MZ6A 2VAQA 2DYHA 2YA8A 4YZ5A 4CH9A 4N1BA 2QWDA 3A71A 1L7HA 2HU0A 1SUUA 4FPLA 2H2UA 1NMBN 3GVLA 1NCDN 3T1EA 4GB1A 4XMAA 5B2CA 3BEQA 2BZDA 2A75A 2FPBA 4GZXA 3A9HA 4FPKA 3K36A 2GVVA 1OFZA 4WA4A 2F28A 1V3BA 4FPOB 1INVA 2QWHA 2VSMA 2IAUA 2V91A 4XJWA 4JF7A 1SLLA 1NNCA 1MS5A 4FOWA 5B2DA 4HZWA 2F13A 2QWCA 4K1KA 2SIMA 1ZI0A 4YW5A 2QWJA 4O5SA 4GN9A 2CMLA 2FLUX 2AEQA 2VK7A 3G4EA 4XMBA 3V65B 1INHA 4HZZA 4CHBA 1IVEA 4FPGA 1CRZA 4J9TA 2DG1A 1E8TA 1MZ5A 1RWLA 3Q6KA 4QN3A 2GVUA 3IAXA 1XOEA 4ASCA 2HU4A 4MWXA 5FWWA 4FPJA 2F10A 4YW3A 4WEFA 4HZVA 3INBA 4WEGA 1C9UA 3TI4A 2DSOA 4MZAA 5FZNA 1EUSA 1Z4XA 4YZ2A 1NMAN 1N1VA 3AMRA 4CPYA 4QN7A 3DASA 1N1SA 2YA7A 4MWRA 4D8SA 3A72A 4M4VA 1IVCA 1USXA 4QN5A 1SNTA 5EX7A 4GJTA 4GZOA 4GEZA 5JYYA 4IN4A 1Z4WA 4BBWA 1WP5A 1WCQA 4FOVA 4GN8A 4YW2A 2B8HA 4IFLX 2HTQA 2VVZA 1RWIA 4X47A 4M3MA 4MWJA 4XJRA 3G4HA 4D52A 1E8VA 1KITA 4XE9A 3KYAA 4L7DA 5FNSA 2W8BA 4D52C 4IFJA 4MWQA 4MJVA 4ZY3A 4KS1A 5HUGA 1QLGA 4AGTA 4C1YB 2OJHA 5CGJA 2BATA 4B7JA 1INXA 2BF6A 3FW0A 1N1TA 4IFNX 2FHRA 5FNRA 1NSDA 2W5NA 3S8VA 3NN9A 3CYEA 4X49A 1A4GA 1F8EA 3HLIA 2IAQA 5D9DA 1SO7A 1N6DA 1MS9A 2X9MA 1B9VA 2HTYA 3VNGA 4QNPA 3SALA 7NN9A 3SOQA 2ZZKA 3NSSA 3S2KA 4MWWA 2ZWAA 2QWAA 3K39A 2H2NA 4XJQA 4YZ1A 4FOQA 1S18A 2BERA 1S0IA 2QWKA 4XHBA 4KS4A 1Z50A 1IVGA 2QWFA 3SOBB 1IVFA 2QWIA 3H72A 3KGGA 4FP3A 2HTRA 1USRA 1N6EA 2ZW9A 3O4PA 2QWBA 1IVBA 1V3DA 1IVDA 3K3AA 4HZYA 2ZB5A 1V0FA 1W8OA 2YDPA 2WOZA 3HLHA 3SOVA 4CPOA 2RKCA 4ZGCA 5HUKA 4FPFA 2F27A 5GX1A 2VW2A 2XZJA
chains in the Genus database with same CATH topology
3VNHA 2VPJA 4IFLX 1U6DX 3WN7A 4CHBA 5FNQA 5FNTA 2DYHA 4CH9A 4N1BA 3ADEA 2ZW9A 1X2JA 4L7BA 4YY8A 4IQKA 4L7DA 5FNSA 1ZGKA 3ZGDA 4IFJA 5FNUA 3VNGA 4ZY3A 2WOZA 2XN4A 4ASCA 5F72C 5CGJA 1X2RA 2ZZKA 5FZJA 4ZGCA 3II7A 2ZWAA 4IN4A 4IFNX 2Z32A 3ZGCA 5FNRA 3WDZA 4L7CA 2FLUX 4XMBA 5FZNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VNH A;  2VPJ A;  4IFL X;  1U6D X;  3WN7 A;  4CHB A;  5FNQ A;  5FNT A;  2DYH A;  4CH9 A;  4N1B A;  3ADE A;  2ZW9 A;  1X2J A;  4L7B A;  4YY8 A;  4IQK A;  4L7D A;  5FNS A;  1ZGK A;  3ZGD A;  4IFJ A;  5FNU A;  3VNG A;  4ZY3 A;  2WOZ A;  2XN4 A;  4ASC A;  5F72 C;  5CGJ A;  1X2R A;  2ZZK A;  5FZJ A;  4ZGC A;  3II7 A;  2ZWA A;  4IN4 A;  4IFN X;  2Z32 A;  3ZGC A;  5FNR A;  3WDZ A;  4L7C A;  2FLU X;  4XMB A;  5FZN A; 
#chains in the Genus database with same CATH topology
 1N1Y A;  5HUM A;  4X6K A;  4KS3 A;  2QWG A;  4O5T A;  1F8C A;  2VSK A;  4YY8 A;  3V64 C;  5GX4 A;  3ZGD A;  1CRU A;  4GZT A;  2C4A A;  2VK6 A;  4CPZ A;  4XIO A;  4JML A;  2GHS A;  4G3N A;  4FP2 A;  1VCU A;  2IAO A;  4ZLR A;  4FPE A;  3V1S A;  4H53 A;  2IAW A;  1WCS A;  3K38 A;  4M4N A;  2W20 A;  2HTU A;  4FZH A;  3CKZ A;  4QN4 A;  4FPY A;  1NSB A;  2DG0 A;  4HW6 A;  3A9G A;  4KS5 A;  1INW A;  2F0Z A;  2VW0 A;  3SRG A;  1W21 A;  2QE8 A;  1VCJ A;  3O9K A;  4I00 A;  3P5B L;  4DGR A;  1SLI A;  2AGS A;  2SLI A;  1NCC N;  2Z32 A;  1INY A;  5GX2 A;  3SRE A;  1NCA N;  2YA6 A;  3VNH A;  3ALW A;  3TI8 A;  1B9S A;  1A14 N;  4X4A A;  4NC5 A;  3ADE A;  1MS1 A;  3H6J A;  4YZ3 A;  4H52 A;  3L6V A;  1L7G A;  1V2I A;  1ZGK A;  4CPL A;  3SIL A;  1NN2 A;  4UF7 A;  1XOG A;  2YDT A;  4K1J A;  1INF A;  2F12 A;  4K1I A;  3BYC A;  4XOG A;  1CVM A;  5M1Z A;  1PJX A;  2F25 A;  4GN7 A;  1Z4Z A;  3II7 A;  2HT7 A;  4SLI A;  4MWV A;  2F29 A;  2IAP A;  3U0S A;  3ZGC A;  2AEP A;  4XJA A;  4K3Y A;  4L7C A;  3LI5 A;  3GVK A;  2P4O A;  3WN7 A;  5D9B A;  5FNQ A;  5FNT A;  2HTV A;  4GNB A;  4CPM A;  4HZX A;  1Q7F A;  1W0O A;  3D12 A;  5HUN A;  3K37 A;  4B7M A;  1NCB N;  1NNA A;  2FP9 A;  4XJZ A;  1B9T A;  1MWE A;  2HQS A;  3TI5 A;  5H47 A;  4GZP A;  5GTQ A;  3S94 A;  3SLI A;  2IAT A;  5EO7 A;  1S0J A;  1X2R A;  4XJ8 A;  4C1Y A;  2YA5 A;  2IAR A;  4HHO A;  1E1A A;  4XIL A;  2QWE A;  4XHX A;  2GVX A;  3NO0 A;  2C4L A;  2YA4 A;  4M4U A;  2W5O A;  4MX0 A;  1V04 A;  2HT5 A;  4FOY A;  1IJQ A;  4FVK A;  4XJ9 A;  3H71 A;  1V3C A;  1X2J A;  4L7B A;  2FPC A;  1EUR A;  1W0P A;  1F8B A;  1MS4 A;  3GVJ A;  2FP8 A;  1MS3 A;  4D4U A;  5F72 C;  1BJI A;  5FZJ A;  4K1H A;  3E5Z A;  4B7N A;  2AH2 A;  3LI3 A;  4GNC A;  3TI6 A;  2F24 A;  2ZB6 A;  4XIK A;  6NN9 A;  4XYX A;  4MWY A;  5HX0 A;  2JKB A;  4MWL A;  2W38 A;  3TC9 A;  3SAN A;  4FPH A;  4IQK A;  3AMS A;  3LI4 A;  4XJU A;  1W1X A;  5GX5 A;  1K32 A;  1W20 A;  1W8N A;  4QN6 A;  3TIA A;  4GDI A;  4AH4 A;  4NN9 A;  4AGI A;  1N6F A;  3D11 A;  2HTW A;  3HRP A;  5EO8 A;  4FPC A;  3O9J A;  4GZW A;  2GVW A;  4IMB A;  1CQ1 A;  4YW1 A;  4NCS A;  1U6D X;  4MZE A;  1F8D A;  3S8Z A;  4GDJ A;  1E8U A;  4FQ4 A;  3JU4 A;  1NMC A;  2VW1 A;  4MWU A;  2IAV A;  3WWA A;  1S1D A;  4PWZ A;  4HIZ A;  4WA3 A;  1NPE A;  1N7D A;  2HT8 A;  4CSD A;  4DG6 A;  3TI3 A;  1MS0 A;  2G8S A;  3CL2 A;  3PJQ A;  3TIB A;  2XN4 A;  1EUT A;  1L7F A;  4KS2 A;  3TIC A;  4MC7 A;  4B7R A;  4WA5 A;  1V0E A;  1V0Z A;  4YW4 A;  3FVZ A;  4B7Q A;  2XCY A;  2VPJ A;  4Q6K A;  2IAX A;  3H73 A;  4GZQ A;  1Z4Y A;  4AHA A;  4D52 B;  4GZS A;  2ISM A;  1Z4V A;  3UC1 A;  2W8B B;  1V3E A;  3CL0 A;  4GNA A;  4CPN A;  2IAS A;  4UOU A;  2F11 A;  2XZK A;  1NNB A;  2IVZ A;  4A0P A;  1DIM A;  1QBI A;  1A4Q A;  2POO A;  5NN9 A;  3W09 A;  3Q6T A;  2VWD A;  3ALX A;  3WDZ A;  1NSC A;  3B7E A;  1C5K A;  1MS8 A;  3Q6P A;  4HHQ A;  3OPZ A;  1IUB A;  4MJU A;  1ING A;  4Q1U A;  5F9T A;  3DR2 A;  1MR5 A;  3B69 A;  2VK5 A;  5FNU A;  5GX3 A;  1H6L A;  1EUU A;  4IYG A;  1POO A;  3WW9 A;  5D9C A;  3I1C A;  2XZI A;  1DIL A;  4FJ6 A;  4YZ4 A;  4R40 A;  2F26 A;  4XMI A;  2SIL A;  1IUC A;  1MZ6 A;  2VAQ A;  2DYH A;  2YA8 A;  4YZ5 A;  4CH9 A;  4N1B A;  2QWD A;  3A71 A;  1L7H A;  2HU0 A;  1SUU A;  4FPL A;  2H2U A;  1NMB N;  3GVL A;  1NCD N;  3T1E A;  4GB1 A;  4XMA A;  5B2C A;  3BEQ A;  2BZD A;  2A75 A;  2FPB A;  4GZX A;  3A9H A;  4FPK A;  3K36 A;  2GVV A;  1OFZ A;  4WA4 A;  2F28 A;  1V3B A;  4FPO B;  1INV A;  2QWH A;  2VSM A;  2IAU A;  2V91 A;  4XJW A;  4JF7 A;  1SLL A;  1NNC A;  1MS5 A;  4FOW A;  5B2D A;  4HZW A;  2F13 A;  2QWC A;  4K1K A;  2SIM A;  1ZI0 A;  4YW5 A;  2QWJ A;  4O5S A;  4GN9 A;  2CML A;  2FLU X;  2AEQ A;  2VK7 A;  3G4E A;  4XMB A;  3V65 B;  1INH A;  4HZZ A;  4CHB A;  1IVE A;  4FPG A;  1CRZ A;  4J9T A;  2DG1 A;  1E8T A;  1MZ5 A;  1RWL A;  3Q6K A;  4QN3 A;  2GVU A;  3IAX A;  1XOE A;  4ASC A;  2HU4 A;  4MWX A;  5FWW A;  4FPJ A;  2F10 A;  4YW3 A;  4WEF A;  4HZV A;  3INB A;  4WEG A;  1C9U A;  3TI4 A;  2DSO A;  4MZA A;  5FZN A;  1EUS A;  1Z4X A;  4YZ2 A;  1NMA N;  1N1V A;  3AMR A;  4CPY A;  4QN7 A;  3DAS A;  1N1S A;  2YA7 A;  4MWR A;  4D8S A;  3A72 A;  4M4V A;  1IVC A;  1USX A;  4QN5 A;  1SNT A;  5EX7 A;  4GJT A;  4GZO A;  4GEZ A;  5JYY A;  4IN4 A;  1Z4W A;  4BBW A;  1WP5 A;  1WCQ A;  4FOV A;  4GN8 A;  4YW2 A;  2B8H A;  4IFL X;  2HTQ A;  2VVZ A;  1RWI A;  4X47 A;  4M3M A;  4MWJ A;  4XJR A;  3G4H A;  4D52 A;  1E8V A;  1KIT A;  4XE9 A;  3KYA A;  4L7D A;  5FNS A;  2W8B A;  4D52 C;  4IFJ A;  4MWQ A;  4MJV A;  4ZY3 A;  4KS1 A;  5HUG A;  1QLG A;  4AGT A;  4C1Y B;  2OJH A;  5CGJ A;  2BAT A;  4B7J A;  1INX A;  2BF6 A;  3FW0 A;  1N1T A;  4IFN X;  2FHR A;  5FNR A;  1NSD A;  2W5N A;  3S8V A;  3NN9 A;  3CYE A;  4X49 A;  1A4G A;  1F8E A;  3HLI A;  2IAQ A;  5D9D A;  1SO7 A;  1N6D A;  1MS9 A;  2X9M A;  1B9V A;  2HTY A;  3VNG A;  4QNP A;  3SAL A;  7NN9 A;  3SOQ A;  2ZZK A;  3NSS A;  3S2K A;  4MWW A;  2ZWA A;  2QWA A;  3K39 A;  2H2N A;  4XJQ A;  4YZ1 A;  4FOQ A;  1S18 A;  2BER A;  1S0I A;  2QWK A;  4XHB A;  4KS4 A;  1Z50 A;  1IVG A;  2QWF A;  3SOB B;  1IVF A;  2QWI A;  3H72 A;  3KGG A;  4FP3 A;  2HTR A;  1USR A;  1N6E A;  2ZW9 A;  3O4P A;  2QWB A;  1IVB A;  1V3D A;  1IVD A;  3K3A A;  4HZY A;  2ZB5 A;  1V0F A;  1W8O A;  2YDP A;  2WOZ A;  3HLH A;  3SOV A;  4CPO A;  2RKC A;  4ZGC A;  5HUK A;  4FPF A;  2F27 A;  5GX1 A;  2VW2 A;  2XZJ A; 
#chains in the Genus database with same CATH homology
 3VNH A;  2VPJ A;  4IFL X;  1U6D X;  3WN7 A;  4CHB A;  5FNQ A;  5FNT A;  2DYH A;  4CH9 A;  4N1B A;  3ADE A;  2ZW9 A;  1X2J A;  4L7B A;  4YY8 A;  4IQK A;  4L7D A;  5FNS A;  1ZGK A;  3ZGD A;  4IFJ A;  5FNU A;  3VNG A;  4ZY3 A;  2WOZ A;  2XN4 A;  4ASC A;  5F72 C;  5CGJ A;  1X2R A;  2ZZK A;  5FZJ A;  4ZGC A;  3II7 A;  2ZWA A;  4IN4 A;  4IFN X;  2Z32 A;  3ZGC A;  5FNR A;  3WDZ A;  4L7C A;  2FLU X;  4XMB A;  5FZN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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