5FNQA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 70

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
source organism Mus musculus
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
total genus 70
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fnqA00
2ZZKA 5FNUA 4IQKA 4N1BA 3ZGDA 4IFNX 4CH9A 4L7CA 4CHBA 2DYHA 3VNGA 2ZWAA 3WDZA 4IFLX 1X2RA 5FZNA 1X2JA 5FNTA 2FLUX 3II7A 1ZGKA 4ZY3A 5FNQA 4L7DA 4XMBA 4IN4A 5FZJA 2Z32A 4YY8A 2WOZA 2VPJA 3VNHA 3ZGCA 4ZGCA 5CGJA 5F72C 1U6DX 4IFJA 5FNRA 3WN7A 2XN4A 4L7BA 4ASCA 3ADEA 5FNSA 2ZW9A
chains in the Genus database with same CATH superfamily
1WCSA 2ZB5A 4HZVA 4DGRA 4FOWA 4IFLX 4D8SA 1NSDA 3AMRA 3G4HA 4FPGA 1OFZA 1F8BA 2IASA 1Q7FA 3S8ZA 4YW5A 4O5TA 4JF7A 4MZAA 4XJWA 1IVEA 2IATA 4MWWA 2ISMA 4XE9A 3OPZA 1S1DA 3LI3A 1W8OA 3ZGCA 1C9UA 1U6DX 4HZWA 1INGA 4FP3A 4XMAA 4FPKA 3B69A 3JU4A 3P5BL 2A75A 4QN3A 4CPMA 1MS3A 1E8TA 4QNPA 1PJXA 2W8BB 4KS4A 5HX0A 2ZWAA 1V3EA 2GVVA 2VK7A 5NN9A 3WW9A 4B7NA 3V64C 1POOA 2VPJA 2F11A 1MS8A 1IVFA 4O5SA 4QN7A 4Q1UA 2W5OA 1RWIA 2HT7A 4AGIA 4FPOB 1Z4ZA 4B7JA 2HU4A 2ZW9A 3HRPA 4HHQA 4A0PA 4IQKA 4YZ2A 3G4EA 2VW2A 1IVBA 3VNGA 2XZIA 3CKZA 5M1ZA 4X47A 4MWQA 2VSKA 1SLIA 5D9DA 3E5ZA 2YA6A 1INVA 4YW2A 2IAPA 2QWEA 2X9MA 3S2KA 2IAOA 4MZEA 1F8EA 4FOVA 5GX5A 2BZDA 1MZ5A 2HTVA 3ZGDA 4FQ4A 2F10A 3HLIA 3SILA 3WDZA 6NN9A 3O9KA 3KYAA 4PWZA 5D9CA 4M4NA 5B2CA 4H53A 3H72A 4WEGA 4FVKA 1CVMA 2F26A 1N7DA 1NNAA 1Z4YA 4MX0A 1C5KA 1N1TA 4XIOA 1S0IA 4WA4A 2FHRA 2SIMA 4GB1A 3S94A 1MR5A 4FOYA 1E1AA 4ZY3A 4L7DA 3SALA 4CPYA 4NCSA 2WOZA 1WP5A 1IJQA 2ZB6A 4FPLA 1Z4WA 4ZGCA 3D11A 2IAUA 2HU0A 2H2UA 4FP2A 4K1HA 2VK6A 2W8BA 4J9TA 2XZKA 1B9VA 3SLIA 4YZ1A 4YW4A 4XILA 3O9JA 3TC9A 4K1IA 4XJUA 4GNCA 2GVXA 1SNTA 2IARA 4GEZA 3I1CA 4XMBA 4X6KA 2Z32A 1W21A 2QWJA 1EUUA 4GZWA 4UOUA 2QWFA 3U0SA 4UF7A 2VK5A 4GZPA 1F8CA 2FPBA 1A4GA 2XN4A 3INBA 4MWLA 4KS1A 2F27A 1KITA 4C1YB 2DSOA 2FPCA 2ZZKA 3HLHA 2HTQA 4GZXA 4Q6KA 1VCUA 2VSMA 3SANA 4CPLA 4XJAA 1SO7A 2BF6A 2IAWA 2FLUX 2GVUA 4WA3A 1V2IA 1USXA 4M3MA 4GNBA 3T1EA 4M4UA 2DG1A 3CYEA 1INXA 1K32A 5F72C 1USRA 4KS5A 3S8VA 3AMSA 3K3AA 4GDIA 1L7FA 3ADEA 3BEQA 5FNSA 2C4LA 4XJ9A 3CL0A 2QE8A 2YDTA 4X49A 2C4AA 1NCBN 2DYHA 3TI5A 2H2NA 5FZNA 5FNTA 1NMBN 1S18A 3NN9A 4XHBA 1NNBA 1Z4VA 2GVWA 2XZJA 4SLIA 1V3CA 3A9GA 1XOEA 4GZQA 4MJVA 4MWVA 4QN4A 5B2DA 2QWAA 4GNAA 1W1XA 5FNUA 4QN6A 1IVDA 3V1SA 2BERA 3K38A 2QWHA 2F13A 2VW1A 3W09A 2HT8A 1NSBA 4AH4A 4YZ4A 3L6VA 2HTYA 3Q6KA 1V0FA 4ZLRA 4AHAA 4FZHA 2BATA 1L7HA 3VNHA 3A71A 2HTRA 5CGJA 4IMBA 4HZXA 1QLGA 3FVZA 3NO0A 1A4QA 5HUKA 3PJQA 1B9SA 3DR2A 4GZSA 4R40A 4MWUA 5GX2A 7NN9A 1MS4A 1INFA 4N1BA 5HUMA 1N1YA 4JMLA 4XOGA 4XJ8A 1N1SA 1NCDN 4YZ3A 3V65B 5FNQA 5FZJA 4D52C 4GJTA 3UC1A 1QBIA 3TI8A 1NNCA 3A72A 4CSDA 1IUCA 4GN7A 4XYXA 5FNRA 3TI6A 4C1YA 1NCCN 4HIZA 4XJZA 4WEFA 3A9HA 2B8HA 4IFNX 4XIKA 4DG6A 3Q6PA 4G3NA 1W0PA 2V91A 2W5NA 4CPZA 3IAXA 1RWLA 4AGTA 2JKBA 1BJIA 2QWKA 4D52B 2YA8A 4WA5A 3GVKA 4BBWA 4MWYA 1H6LA 3Q6TA 4YZ5A 4H52A 1V04A 4FJ6A 3TI4A 1E8VA 1W0OA 1NSCA 2F0ZA 1NMAN 1MS5A 2F28A 4L7BA 1SLLA 1V3DA 5GX1A 2F29A 2QWDA 4X4AA 1INHA 1CQ1A 2F25A 4YW1A 4FPYA 4CH9A 5HUNA 2QWCA 2HTWA 2FP8A 1XOGA 5EO7A 1X2JA 3KGGA 2FP9A 1CRZA 1ZI0A 1ZGKA 4CPNA 1CRUA 5FWWA 4B7QA 4XMIA 3LI5A 1N6EA 1V0EA 1MS1A 4MJUA 3TIBA 2HTUA 4GN8A 1N6FA 2AGSA 3H71A 4FPHA 4I00A 4MWJA 5GTQA 1B9TA 4HZZA 4CHBA 1F8DA 1NMCA 4KS2A 1W8NA 2VWDA 4YW3A 2IVZA 2W20A 3SREA 1DIMA 3D12A 3GVLA 2OJHA 1EUSA 4FPCA 1Z50A 3H6JA 2IAVA 3BYCA 4MWRA 1NCAN 1S0JA 2QWIA 2G8SA 4B7MA 2AEPA 4GN9A 3WN7A 2VAQA 1MZ6A 1SUUA 4K1JA 5EO8A 3TI3A 4K3YA 4ASCA 5HUGA 2GHSA 1N1VA 2SILA 1V3BA 4L7CA 2F24A 1A14N 2IAQA 4IYGA 3SOVA 1L7GA 4FPJA 4XJQA 2RKCA 1IVGA 4XJRA 2HQSA 2VVZA 4YY8A 2YA5A 4FPFA 2SLIA 5F9TA 3K36A 2CMLA 4B7RA 3TIAA 3DASA 2YA7A 3ALWA 4M4VA 1E8UA 3O4PA 5JYYA 3LI4A 2AH2A 2IAXA 1N6DA 1NN2A 3TICA 1MS0A 2DG0A 4D4UA 2AEQA 1Z4XA 4HHOA 5D9BA 1EURA 3GVJA 1X2RA 4D52A 3II7A 4GZOA 2W38A 4IN4A 1VCJA 3SOBB 4MC7A 3SRGA 1MS9A 1V0ZA 4XHXA 4K1KA 3ALXA 2XCYA 3FW0A 4IFJA 1INWA 1IUBA 4GZTA 4HW6A 1DILA 1IVCA 3K39A 2F12A 4FPEA 1WCQA 4FOQA 1NPEA 3CL2A 2P4OA 5H47A 3K37A 5EX7A 3H73A 4NN9A 2HT5A 2VW0A 4NC5A 2YA4A 1MWEA 4QN5A 1INYA 2POOA 1W20A 4HZYA 1EUTA 4MWXA 4CPOA 3NSSA 2QWGA 5GX3A 3SOQA 4KS3A 4GDJA 3B7EA 5GX4A 3WWAA 2YDPA 2QWBA
chains in the Genus database with same CATH topology
2ZZKA 5FNUA 4IQKA 4N1BA 3ZGDA 4IFNX 4CH9A 4L7CA 4CHBA 2DYHA 3VNGA 2ZWAA 3WDZA 4IFLX 1X2RA 5FZNA 1X2JA 5FNTA 2FLUX 3II7A 1ZGKA 4ZY3A 5FNQA 4L7DA 4XMBA 4IN4A 5FZJA 2Z32A 4YY8A 2WOZA 2VPJA 3VNHA 3ZGCA 4ZGCA 5CGJA 5F72C 1U6DX 4IFJA 5FNRA 3WN7A 2XN4A 4L7BA 4ASCA 3ADEA 5FNSA 2ZW9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZZK A;  5FNU A;  4IQK A;  4N1B A;  3ZGD A;  4IFN X;  4CH9 A;  4L7C A;  4CHB A;  2DYH A;  3VNG A;  2ZWA A;  3WDZ A;  4IFL X;  1X2R A;  5FZN A;  1X2J A;  5FNT A;  2FLU X;  3II7 A;  1ZGK A;  4ZY3 A;  5FNQ A;  4L7D A;  4XMB A;  4IN4 A;  5FZJ A;  2Z32 A;  4YY8 A;  2WOZ A;  2VPJ A;  3VNH A;  3ZGC A;  4ZGC A;  5CGJ A;  5F72 C;  1U6D X;  4IFJ A;  5FNR A;  3WN7 A;  2XN4 A;  4L7B A;  4ASC A;  3ADE A;  5FNS A;  2ZW9 A; 
#chains in the Genus database with same CATH topology
 1WCS A;  2ZB5 A;  4HZV A;  4DGR A;  4FOW A;  4IFL X;  4D8S A;  1NSD A;  3AMR A;  3G4H A;  4FPG A;  1OFZ A;  1F8B A;  2IAS A;  1Q7F A;  3S8Z A;  4YW5 A;  4O5T A;  4JF7 A;  4MZA A;  4XJW A;  1IVE A;  2IAT A;  4MWW A;  2ISM A;  4XE9 A;  3OPZ A;  1S1D A;  3LI3 A;  1W8O A;  3ZGC A;  1C9U A;  1U6D X;  4HZW A;  1ING A;  4FP3 A;  4XMA A;  4FPK A;  3B69 A;  3JU4 A;  3P5B L;  2A75 A;  4QN3 A;  4CPM A;  1MS3 A;  1E8T A;  4QNP A;  1PJX A;  2W8B B;  4KS4 A;  5HX0 A;  2ZWA A;  1V3E A;  2GVV A;  2VK7 A;  5NN9 A;  3WW9 A;  4B7N A;  3V64 C;  1POO A;  2VPJ A;  2F11 A;  1MS8 A;  1IVF A;  4O5S A;  4QN7 A;  4Q1U A;  2W5O A;  1RWI A;  2HT7 A;  4AGI A;  4FPO B;  1Z4Z A;  4B7J A;  2HU4 A;  2ZW9 A;  3HRP A;  4HHQ A;  4A0P A;  4IQK A;  4YZ2 A;  3G4E A;  2VW2 A;  1IVB A;  3VNG A;  2XZI A;  3CKZ A;  5M1Z A;  4X47 A;  4MWQ A;  2VSK A;  1SLI A;  5D9D A;  3E5Z A;  2YA6 A;  1INV A;  4YW2 A;  2IAP A;  2QWE A;  2X9M A;  3S2K A;  2IAO A;  4MZE A;  1F8E A;  4FOV A;  5GX5 A;  2BZD A;  1MZ5 A;  2HTV A;  3ZGD A;  4FQ4 A;  2F10 A;  3HLI A;  3SIL A;  3WDZ A;  6NN9 A;  3O9K A;  3KYA A;  4PWZ A;  5D9C A;  4M4N A;  5B2C A;  4H53 A;  3H72 A;  4WEG A;  4FVK A;  1CVM A;  2F26 A;  1N7D A;  1NNA A;  1Z4Y A;  4MX0 A;  1C5K A;  1N1T A;  4XIO A;  1S0I A;  4WA4 A;  2FHR A;  2SIM A;  4GB1 A;  3S94 A;  1MR5 A;  4FOY A;  1E1A A;  4ZY3 A;  4L7D A;  3SAL A;  4CPY A;  4NCS A;  2WOZ A;  1WP5 A;  1IJQ A;  2ZB6 A;  4FPL A;  1Z4W A;  4ZGC A;  3D11 A;  2IAU A;  2HU0 A;  2H2U A;  4FP2 A;  4K1H A;  2VK6 A;  2W8B A;  4J9T A;  2XZK A;  1B9V A;  3SLI A;  4YZ1 A;  4YW4 A;  4XIL A;  3O9J A;  3TC9 A;  4K1I A;  4XJU A;  4GNC A;  2GVX A;  1SNT A;  2IAR A;  4GEZ A;  3I1C A;  4XMB A;  4X6K A;  2Z32 A;  1W21 A;  2QWJ A;  1EUU A;  4GZW A;  4UOU A;  2QWF A;  3U0S A;  4UF7 A;  2VK5 A;  4GZP A;  1F8C A;  2FPB A;  1A4G A;  2XN4 A;  3INB A;  4MWL A;  4KS1 A;  2F27 A;  1KIT A;  4C1Y B;  2DSO A;  2FPC A;  2ZZK A;  3HLH A;  2HTQ A;  4GZX A;  4Q6K A;  1VCU A;  2VSM A;  3SAN A;  4CPL A;  4XJA A;  1SO7 A;  2BF6 A;  2IAW A;  2FLU X;  2GVU A;  4WA3 A;  1V2I A;  1USX A;  4M3M A;  4GNB A;  3T1E A;  4M4U A;  2DG1 A;  3CYE A;  1INX A;  1K32 A;  5F72 C;  1USR A;  4KS5 A;  3S8V A;  3AMS A;  3K3A A;  4GDI A;  1L7F A;  3ADE A;  3BEQ A;  5FNS A;  2C4L A;  4XJ9 A;  3CL0 A;  2QE8 A;  2YDT A;  4X49 A;  2C4A A;  1NCB N;  2DYH A;  3TI5 A;  2H2N A;  5FZN A;  5FNT A;  1NMB N;  1S18 A;  3NN9 A;  4XHB A;  1NNB A;  1Z4V A;  2GVW A;  2XZJ A;  4SLI A;  1V3C A;  3A9G A;  1XOE A;  4GZQ A;  4MJV A;  4MWV A;  4QN4 A;  5B2D A;  2QWA A;  4GNA A;  1W1X A;  5FNU A;  4QN6 A;  1IVD A;  3V1S A;  2BER A;  3K38 A;  2QWH A;  2F13 A;  2VW1 A;  3W09 A;  2HT8 A;  1NSB A;  4AH4 A;  4YZ4 A;  3L6V A;  2HTY A;  3Q6K A;  1V0F A;  4ZLR A;  4AHA A;  4FZH A;  2BAT A;  1L7H A;  3VNH A;  3A71 A;  2HTR A;  5CGJ A;  4IMB A;  4HZX A;  1QLG A;  3FVZ A;  3NO0 A;  1A4Q A;  5HUK A;  3PJQ A;  1B9S A;  3DR2 A;  4GZS A;  4R40 A;  4MWU A;  5GX2 A;  7NN9 A;  1MS4 A;  1INF A;  4N1B A;  5HUM A;  1N1Y A;  4JML A;  4XOG A;  4XJ8 A;  1N1S A;  1NCD N;  4YZ3 A;  3V65 B;  5FNQ A;  5FZJ A;  4D52 C;  4GJT A;  3UC1 A;  1QBI A;  3TI8 A;  1NNC A;  3A72 A;  4CSD A;  1IUC A;  4GN7 A;  4XYX A;  5FNR A;  3TI6 A;  4C1Y A;  1NCC N;  4HIZ A;  4XJZ A;  4WEF A;  3A9H A;  2B8H A;  4IFN X;  4XIK A;  4DG6 A;  3Q6P A;  4G3N A;  1W0P A;  2V91 A;  2W5N A;  4CPZ A;  3IAX A;  1RWL A;  4AGT A;  2JKB A;  1BJI A;  2QWK A;  4D52 B;  2YA8 A;  4WA5 A;  3GVK A;  4BBW A;  4MWY A;  1H6L A;  3Q6T A;  4YZ5 A;  4H52 A;  1V04 A;  4FJ6 A;  3TI4 A;  1E8V A;  1W0O A;  1NSC A;  2F0Z A;  1NMA N;  1MS5 A;  2F28 A;  4L7B A;  1SLL A;  1V3D A;  5GX1 A;  2F29 A;  2QWD A;  4X4A A;  1INH A;  1CQ1 A;  2F25 A;  4YW1 A;  4FPY A;  4CH9 A;  5HUN A;  2QWC A;  2HTW A;  2FP8 A;  1XOG A;  5EO7 A;  1X2J A;  3KGG A;  2FP9 A;  1CRZ A;  1ZI0 A;  1ZGK A;  4CPN A;  1CRU A;  5FWW A;  4B7Q A;  4XMI A;  3LI5 A;  1N6E A;  1V0E A;  1MS1 A;  4MJU A;  3TIB A;  2HTU A;  4GN8 A;  1N6F A;  2AGS A;  3H71 A;  4FPH A;  4I00 A;  4MWJ A;  5GTQ A;  1B9T A;  4HZZ A;  4CHB A;  1F8D A;  1NMC A;  4KS2 A;  1W8N A;  2VWD A;  4YW3 A;  2IVZ A;  2W20 A;  3SRE A;  1DIM A;  3D12 A;  3GVL A;  2OJH A;  1EUS A;  4FPC A;  1Z50 A;  3H6J A;  2IAV A;  3BYC A;  4MWR A;  1NCA N;  1S0J A;  2QWI A;  2G8S A;  4B7M A;  2AEP A;  4GN9 A;  3WN7 A;  2VAQ A;  1MZ6 A;  1SUU A;  4K1J A;  5EO8 A;  3TI3 A;  4K3Y A;  4ASC A;  5HUG A;  2GHS A;  1N1V A;  2SIL A;  1V3B A;  4L7C A;  2F24 A;  1A14 N;  2IAQ A;  4IYG A;  3SOV A;  1L7G A;  4FPJ A;  4XJQ A;  2RKC A;  1IVG A;  4XJR A;  2HQS A;  2VVZ A;  4YY8 A;  2YA5 A;  4FPF A;  2SLI A;  5F9T A;  3K36 A;  2CML A;  4B7R A;  3TIA A;  3DAS A;  2YA7 A;  3ALW A;  4M4V A;  1E8U A;  3O4P A;  5JYY A;  3LI4 A;  2AH2 A;  2IAX A;  1N6D A;  1NN2 A;  3TIC A;  1MS0 A;  2DG0 A;  4D4U A;  2AEQ A;  1Z4X A;  4HHO A;  5D9B A;  1EUR A;  3GVJ A;  1X2R A;  4D52 A;  3II7 A;  4GZO A;  2W38 A;  4IN4 A;  1VCJ A;  3SOB B;  4MC7 A;  3SRG A;  1MS9 A;  1V0Z A;  4XHX A;  4K1K A;  3ALX A;  2XCY A;  3FW0 A;  4IFJ A;  1INW A;  1IUB A;  4GZT A;  4HW6 A;  1DIL A;  1IVC A;  3K39 A;  2F12 A;  4FPE A;  1WCQ A;  4FOQ A;  1NPE A;  3CL2 A;  2P4O A;  5H47 A;  3K37 A;  5EX7 A;  3H73 A;  4NN9 A;  2HT5 A;  2VW0 A;  4NC5 A;  2YA4 A;  1MWE A;  4QN5 A;  1INY A;  2POO A;  1W20 A;  4HZY A;  1EUT A;  4MWX A;  4CPO A;  3NSS A;  2QWG A;  5GX3 A;  3SOQ A;  4KS3 A;  4GDJ A;  3B7E A;  5GX4 A;  3WWA A;  2YDP A;  2QWB A; 
#chains in the Genus database with same CATH homology
 2ZZK A;  5FNU A;  4IQK A;  4N1B A;  3ZGD A;  4IFN X;  4CH9 A;  4L7C A;  4CHB A;  2DYH A;  3VNG A;  2ZWA A;  3WDZ A;  4IFL X;  1X2R A;  5FZN A;  1X2J A;  5FNT A;  2FLU X;  3II7 A;  1ZGK A;  4ZY3 A;  5FNQ A;  4L7D A;  4XMB A;  4IN4 A;  5FZJ A;  2Z32 A;  4YY8 A;  2WOZ A;  2VPJ A;  3VNH A;  3ZGC A;  4ZGC A;  5CGJ A;  5F72 C;  1U6D X;  4IFJ A;  5FNR A;  3WN7 A;  2XN4 A;  4L7B A;  4ASC A;  3ADE A;  5FNS A;  2ZW9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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