5FNRA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 65

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
289
structure length
289
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
source organism Mus musculus
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
total genus 65
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fnrA00
1X2RA 3WDZA 4N1BA 4YY8A 4IQKA 3WN7A 4IFLX 2WOZA 3ADEA 2VPJA 3ZGDA 4CH9A 4IFNX 1U6DX 1ZGKA 5F72C 5CGJA 2ZZKA 3VNHA 1X2JA 3II7A 4ZY3A 4IFJA 2ZW9A 5FNTA 4L7CA 4CHBA 4L7BA 4ZGCA 4XMBA 5FNRA 3ZGCA 5FNUA 2Z32A 2ZWAA 2FLUX 2DYHA 5FNQA 5FNSA 4ASCA 4IN4A 5FZJA 5FZNA 3VNGA 4L7DA 2XN4A
chains in the Genus database with same CATH superfamily
4X6KA 1CQ1A 2C4LA 1VCUA 4AHAA 6NN9A 4DG6A 4GZTA 4D52B 1V0ZA 3G4EA 4QN3A 1MWEA 4AGIA 4L7BA 1EUUA 4CPOA 4D52A 1INGA 4GN8A 4D52C 2YDPA 1DIMA 2HTRA 4HZZA 4GNAA 4XJWA 1MS9A 4GZQA 3FVZA 2FPCA 1E8UA 5B2CA 1INFA 3TIAA 3VNHA 4FOYA 1S0JA 4C1YB 4MWVA 2YDTA 4O5TA 2QWCA 1SLIA 3Q6KA 1NMBN 2DG0A 2XZKA 1C5KA 4XIOA 1B9TA 1N6DA 2IAQA 4B7MA 1L7GA 4FQ4A 4ASCA 4GZWA 5EX7A 4YW1A 1E8VA 4FP2A 2HTUA 3U0SA 1USXA 4XHBA 3WDZA 4JMLA 1V2IA 4M4NA 1Z4WA 1ZGKA 2RKCA 4XJUA 1V3EA 4UOUA 1INYA 1NCCN 1NSCA 1N1TA 2OJHA 1IVDA 2BERA 2GVUA 1WCSA 4X47A 5JYYA 3LI5A 1E1AA 4FPHA 1MZ6A 4IN4A 4XJ8A 5EO8A 2HT7A 1A4GA 1IUBA 3TIBA 1X2RA 5B2DA 5H47A 4JF7A 4IFLX 3Q6PA 1BJIA 1VCJA 1XOGA 3ADEA 1NPEA 2IAXA 4KS3A 5CGJA 1V04A 2YA8A 1KITA 1PJXA 4FPKA 5D9CA 4J9TA 4KS5A 2QWGA 3D11A 1NN2A 1F8DA 3O9JA 3S2KA 1MS5A 2QWJA 1IVEA 4FPCA 4Q1UA 2FHRA 3HRPA 1N7DA 2F24A 3CL2A 4HZYA 4XYXA 1IUCA 1OFZA 2AEQA 2JKBA 4GNBA 2F10A 4M4UA 3CYEA 4GZOA 2VPJA 2ZB6A 1W21A 3A72A 3TI3A 2A75A 4IFNX 5FWWA 4WEGA 1SO7A 4HIZA 1N6EA 4HHQA 4ZY3A 1NMCA 2C4AA 4MC7A 2HU4A 5FNRA 2BATA 3HLHA 4GZPA 4MWUA 5FNSA 3CKZA 3GVJA 5GX2A 4YW4A 2HTVA 3B7EA 3Q6TA 1EURA 2VSMA 3SRGA 1RWLA 1S0IA 7NN9A 1IVCA 4XMBA 4H52A 3WN7A 3GVKA 1B9SA 3E5ZA 4QN7A 1Z4YA 2QWAA 1POOA 2HQSA 2ZB5A 3P5BL 1MR5A 1F8EA 1Z4ZA 3K3AA 2HU0A 2IAWA 4YW3A 4CHBA 4X49A 4B7QA 1Z4VA 4FPYA 1N6FA 4DGRA 4IMBA 5GTQA 4B7RA 1USRA 5HUNA 4FOVA 4YW2A 1V3BA 4FOWA 2YA5A 4QN5A 3S94A 3TI6A 4D4UA 3K38A 1SLLA 1QLGA 2F13A 4YZ3A 4FPLA 4XJZA 4FPOB 3ZGCA 1MS0A 4FVKA 4I00A 1CVMA 3FW0A 4XJ9A 1K32A 4CH9A 2W20A 4MJVA 5HUMA 4YY8A 4BBWA 4YZ5A 4XHXA 3ALWA 2HT5A 2VW2A 1E8TA 1U6DX 2IAUA 4XMAA 3SILA 1QBIA 2X9MA 3A9GA 3O9KA 4MWYA 4XOGA 5FNTA 2VAQA 4MWLA 1INXA 4CSDA 2BF6A 2QWEA 3TICA 2W38A 2F27A 5FNUA 1NMAN 2VK7A 4GJTA 2CMLA 3UC1A 3V65B 1NCDN 2F12A 1ZI0A 4H53A 3SOVA 4YZ2A 3W09A 3HLIA 2GVXA 4XJAA 4O5SA 4WA3A 4GDJA 2FP8A 2VW1A 4MJUA 2AGSA 3TI4A 1NSDA 4XMIA 1A14N 3B69A 4FJ6A 4HHOA 4K1JA 3SOBB 3TC9A 3S8ZA 3SALA 3INBA 4MWQA 3O4PA 1DILA 5EO7A 2VSKA 2IAPA 4MZEA 5FNQA 1NCAN 1MS8A 4GEZA 1RWIA 1MS3A 4MWRA 3NN9A 1V0FA 4FPEA 4B7NA 1C9UA 1IVBA 2GHSA 4UF7A 4YZ4A 2QWKA 5HUGA 5M1ZA 1WP5A 2GVVA 2QE8A 3SREA 3PJQA 4R40A 4NCSA 4KS1A 1W20A 2YA7A 1WCQA 1IJQA 4WEFA 3TI8A 5FZJA 4QNPA 4ZLRA 3L6VA 2IAOA 2XN4A 4IYGA 4PWZA 2QWIA 2DSOA 3V64C 3LI4A 2IAVA 4CPYA 4CPNA 3NSSA 1Q7FA 5F72C 3SANA 2W5NA 3H71A 3G4HA 3K37A 4A0PA 4HW6A 5GX5A 3BYCA 2XZIA 1Z4XA 4GN9A 4ZGCA 3K36A 1NCBN 3T1EA 4MWWA 1W8OA 2XZJA 5FZNA 3TI5A 2AH2A 3KGGA 2QWHA 3AMSA 3CL0A 4FPJA 3WWAA 2VVZA 3ZGDA 4KS2A 2AEPA 1W0PA 2F26A 2SLIA 1X2JA 2IVZA 2B8HA 1S18A 3II7A 4MWJA 2H2UA 4GNCA 5GX4A 4GB1A 1W0OA 1Z50A 4HZWA 4M3MA 1L7FA 2F11A 2SIMA 4K1KA 3D12A 3NO0A 2QWDA 1S1DA 1V3CA 2HTWA 2POOA 3H6JA 4FPGA 3BEQA 4L7DA 2V91A 1MZ5A 2HT8A 4NC5A 4FOQA 1F8BA 3SOQA 5F9TA 3A9HA 3H72A 2QWFA 3KYAA 2W5OA 2SILA 1H6LA 2F0ZA 4L7CA 4GZXA 4C1YA 2F25A 4Q6KA 4XJQA 1EUSA 4MZAA 1INWA 3K39A 1SUUA 2DYHA 1A4QA 1MS4A 2DG1A 2BZDA 3V1SA 4FPFA 4FP3A 5GX1A 4FZHA 1MS1A 2ISMA 1N1SA 4GN7A 4K3YA 2IASA 4GDIA 2FP9A 4HZXA 1INHA 4B7JA 1EUTA 2YA6A 3DR2A 2XCYA 3LI3A 2IARA 3H73A 1L7HA 4IFJA 2ZW9A 2QWBA 2VK6A 2HTYA 4G3NA 1CRZA 5HX0A 2GVWA 4XE9A 2Z32A 4YZ1A 5NN9A 5HUKA 2F28A 5GX3A 4K1IA 4KS4A 2H2NA 1W8NA 1SNTA 1NSBA 2FPBA 2IATA 2VWDA 5D9DA 2VW0A 4K1HA 4GZSA 4IQKA 4QN4A 2G8SA 4AH4A 4QN6A 3JU4A 1F8CA 3A71A 1N1YA 4WA5A 2P4OA 5D9BA 2F29A 4HZVA 1NNAA 3SLIA 1INVA 1W1XA 2ZWAA 4X4AA 2FLUX 1N1VA 4MWXA 4MX0A 2HTQA 1B9VA 2W8BB 1CRUA 3S8VA 4WA4A 4SLIA 4NN9A 4CPLA 4N1BA 2W8BA 1NNCA 4YW5A 1IVFA 1NNBA 2WOZA 4CPMA 4XILA 2ZZKA 1IVGA 4XIKA 4CPZA 3ALXA 3I1CA 3IAXA 3OPZA 3GVLA 4M4VA 3DASA 2VK5A 1V0EA 4AGTA 3AMRA 2YA4A 1XOEA 3WW9A 4XJRA 3VNGA 4D8SA 1V3DA
chains in the Genus database with same CATH topology
1X2RA 3WDZA 4N1BA 4YY8A 4IQKA 3WN7A 4IFLX 2WOZA 3ADEA 2VPJA 3ZGDA 4CH9A 4IFNX 1U6DX 1ZGKA 5F72C 5CGJA 2ZZKA 3VNHA 1X2JA 3II7A 4ZY3A 4IFJA 2ZW9A 5FNTA 4L7CA 4CHBA 4L7BA 4ZGCA 4XMBA 5FNRA 3ZGCA 5FNUA 2Z32A 2ZWAA 2FLUX 2DYHA 5FNQA 5FNSA 4ASCA 4IN4A 5FZJA 5FZNA 3VNGA 4L7DA 2XN4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1X2R A;  3WDZ A;  4N1B A;  4YY8 A;  4IQK A;  3WN7 A;  4IFL X;  2WOZ A;  3ADE A;  2VPJ A;  3ZGD A;  4CH9 A;  4IFN X;  1U6D X;  1ZGK A;  5F72 C;  5CGJ A;  2ZZK A;  3VNH A;  1X2J A;  3II7 A;  4ZY3 A;  4IFJ A;  2ZW9 A;  5FNT A;  4L7C A;  4CHB A;  4L7B A;  4ZGC A;  4XMB A;  5FNR A;  3ZGC A;  5FNU A;  2Z32 A;  2ZWA A;  2FLU X;  2DYH A;  5FNQ A;  5FNS A;  4ASC A;  4IN4 A;  5FZJ A;  5FZN A;  3VNG A;  4L7D A;  2XN4 A; 
#chains in the Genus database with same CATH topology
 4X6K A;  1CQ1 A;  2C4L A;  1VCU A;  4AHA A;  6NN9 A;  4DG6 A;  4GZT A;  4D52 B;  1V0Z A;  3G4E A;  4QN3 A;  1MWE A;  4AGI A;  4L7B A;  1EUU A;  4CPO A;  4D52 A;  1ING A;  4GN8 A;  4D52 C;  2YDP A;  1DIM A;  2HTR A;  4HZZ A;  4GNA A;  4XJW A;  1MS9 A;  4GZQ A;  3FVZ A;  2FPC A;  1E8U A;  5B2C A;  1INF A;  3TIA A;  3VNH A;  4FOY A;  1S0J A;  4C1Y B;  4MWV A;  2YDT A;  4O5T A;  2QWC A;  1SLI A;  3Q6K A;  1NMB N;  2DG0 A;  2XZK A;  1C5K A;  4XIO A;  1B9T A;  1N6D A;  2IAQ A;  4B7M A;  1L7G A;  4FQ4 A;  4ASC A;  4GZW A;  5EX7 A;  4YW1 A;  1E8V A;  4FP2 A;  2HTU A;  3U0S A;  1USX A;  4XHB A;  3WDZ A;  4JML A;  1V2I A;  4M4N A;  1Z4W A;  1ZGK A;  2RKC A;  4XJU A;  1V3E A;  4UOU A;  1INY A;  1NCC N;  1NSC A;  1N1T A;  2OJH A;  1IVD A;  2BER A;  2GVU A;  1WCS A;  4X47 A;  5JYY A;  3LI5 A;  1E1A A;  4FPH A;  1MZ6 A;  4IN4 A;  4XJ8 A;  5EO8 A;  2HT7 A;  1A4G A;  1IUB A;  3TIB A;  1X2R A;  5B2D A;  5H47 A;  4JF7 A;  4IFL X;  3Q6P A;  1BJI A;  1VCJ A;  1XOG A;  3ADE A;  1NPE A;  2IAX A;  4KS3 A;  5CGJ A;  1V04 A;  2YA8 A;  1KIT A;  1PJX A;  4FPK A;  5D9C A;  4J9T A;  4KS5 A;  2QWG A;  3D11 A;  1NN2 A;  1F8D A;  3O9J A;  3S2K A;  1MS5 A;  2QWJ A;  1IVE A;  4FPC A;  4Q1U A;  2FHR A;  3HRP A;  1N7D A;  2F24 A;  3CL2 A;  4HZY A;  4XYX A;  1IUC A;  1OFZ A;  2AEQ A;  2JKB A;  4GNB A;  2F10 A;  4M4U A;  3CYE A;  4GZO A;  2VPJ A;  2ZB6 A;  1W21 A;  3A72 A;  3TI3 A;  2A75 A;  4IFN X;  5FWW A;  4WEG A;  1SO7 A;  4HIZ A;  1N6E A;  4HHQ A;  4ZY3 A;  1NMC A;  2C4A A;  4MC7 A;  2HU4 A;  5FNR A;  2BAT A;  3HLH A;  4GZP A;  4MWU A;  5FNS A;  3CKZ A;  3GVJ A;  5GX2 A;  4YW4 A;  2HTV A;  3B7E A;  3Q6T A;  1EUR A;  2VSM A;  3SRG A;  1RWL A;  1S0I A;  7NN9 A;  1IVC A;  4XMB A;  4H52 A;  3WN7 A;  3GVK A;  1B9S A;  3E5Z A;  4QN7 A;  1Z4Y A;  2QWA A;  1POO A;  2HQS A;  2ZB5 A;  3P5B L;  1MR5 A;  1F8E A;  1Z4Z A;  3K3A A;  2HU0 A;  2IAW A;  4YW3 A;  4CHB A;  4X49 A;  4B7Q A;  1Z4V A;  4FPY A;  1N6F A;  4DGR A;  4IMB A;  5GTQ A;  4B7R A;  1USR A;  5HUN A;  4FOV A;  4YW2 A;  1V3B A;  4FOW A;  2YA5 A;  4QN5 A;  3S94 A;  3TI6 A;  4D4U A;  3K38 A;  1SLL A;  1QLG A;  2F13 A;  4YZ3 A;  4FPL A;  4XJZ A;  4FPO B;  3ZGC A;  1MS0 A;  4FVK A;  4I00 A;  1CVM A;  3FW0 A;  4XJ9 A;  1K32 A;  4CH9 A;  2W20 A;  4MJV A;  5HUM A;  4YY8 A;  4BBW A;  4YZ5 A;  4XHX A;  3ALW A;  2HT5 A;  2VW2 A;  1E8T A;  1U6D X;  2IAU A;  4XMA A;  3SIL A;  1QBI A;  2X9M A;  3A9G A;  3O9K A;  4MWY A;  4XOG A;  5FNT A;  2VAQ A;  4MWL A;  1INX A;  4CSD A;  2BF6 A;  2QWE A;  3TIC A;  2W38 A;  2F27 A;  5FNU A;  1NMA N;  2VK7 A;  4GJT A;  2CML A;  3UC1 A;  3V65 B;  1NCD N;  2F12 A;  1ZI0 A;  4H53 A;  3SOV A;  4YZ2 A;  3W09 A;  3HLI A;  2GVX A;  4XJA A;  4O5S A;  4WA3 A;  4GDJ A;  2FP8 A;  2VW1 A;  4MJU A;  2AGS A;  3TI4 A;  1NSD A;  4XMI A;  1A14 N;  3B69 A;  4FJ6 A;  4HHO A;  4K1J A;  3SOB B;  3TC9 A;  3S8Z A;  3SAL A;  3INB A;  4MWQ A;  3O4P A;  1DIL A;  5EO7 A;  2VSK A;  2IAP A;  4MZE A;  5FNQ A;  1NCA N;  1MS8 A;  4GEZ A;  1RWI A;  1MS3 A;  4MWR A;  3NN9 A;  1V0F A;  4FPE A;  4B7N A;  1C9U A;  1IVB A;  2GHS A;  4UF7 A;  4YZ4 A;  2QWK A;  5HUG A;  5M1Z A;  1WP5 A;  2GVV A;  2QE8 A;  3SRE A;  3PJQ A;  4R40 A;  4NCS A;  4KS1 A;  1W20 A;  2YA7 A;  1WCQ A;  1IJQ A;  4WEF A;  3TI8 A;  5FZJ A;  4QNP A;  4ZLR A;  3L6V A;  2IAO A;  2XN4 A;  4IYG A;  4PWZ A;  2QWI A;  2DSO A;  3V64 C;  3LI4 A;  2IAV A;  4CPY A;  4CPN A;  3NSS A;  1Q7F A;  5F72 C;  3SAN A;  2W5N A;  3H71 A;  3G4H A;  3K37 A;  4A0P A;  4HW6 A;  5GX5 A;  3BYC A;  2XZI A;  1Z4X A;  4GN9 A;  4ZGC A;  3K36 A;  1NCB N;  3T1E A;  4MWW A;  1W8O A;  2XZJ A;  5FZN A;  3TI5 A;  2AH2 A;  3KGG A;  2QWH A;  3AMS A;  3CL0 A;  4FPJ A;  3WWA A;  2VVZ A;  3ZGD A;  4KS2 A;  2AEP A;  1W0P A;  2F26 A;  2SLI A;  1X2J A;  2IVZ A;  2B8H A;  1S18 A;  3II7 A;  4MWJ A;  2H2U A;  4GNC A;  5GX4 A;  4GB1 A;  1W0O A;  1Z50 A;  4HZW A;  4M3M A;  1L7F A;  2F11 A;  2SIM A;  4K1K A;  3D12 A;  3NO0 A;  2QWD A;  1S1D A;  1V3C A;  2HTW A;  2POO A;  3H6J A;  4FPG A;  3BEQ A;  4L7D A;  2V91 A;  1MZ5 A;  2HT8 A;  4NC5 A;  4FOQ A;  1F8B A;  3SOQ A;  5F9T A;  3A9H A;  3H72 A;  2QWF A;  3KYA A;  2W5O A;  2SIL A;  1H6L A;  2F0Z A;  4L7C A;  4GZX A;  4C1Y A;  2F25 A;  4Q6K A;  4XJQ A;  1EUS A;  4MZA A;  1INW A;  3K39 A;  1SUU A;  2DYH A;  1A4Q A;  1MS4 A;  2DG1 A;  2BZD A;  3V1S A;  4FPF A;  4FP3 A;  5GX1 A;  4FZH A;  1MS1 A;  2ISM A;  1N1S A;  4GN7 A;  4K3Y A;  2IAS A;  4GDI A;  2FP9 A;  4HZX A;  1INH A;  4B7J A;  1EUT A;  2YA6 A;  3DR2 A;  2XCY A;  3LI3 A;  2IAR A;  3H73 A;  1L7H A;  4IFJ A;  2ZW9 A;  2QWB A;  2VK6 A;  2HTY A;  4G3N A;  1CRZ A;  5HX0 A;  2GVW A;  4XE9 A;  2Z32 A;  4YZ1 A;  5NN9 A;  5HUK A;  2F28 A;  5GX3 A;  4K1I A;  4KS4 A;  2H2N A;  1W8N A;  1SNT A;  1NSB A;  2FPB A;  2IAT A;  2VWD A;  5D9D A;  2VW0 A;  4K1H A;  4GZS A;  4IQK A;  4QN4 A;  2G8S A;  4AH4 A;  4QN6 A;  3JU4 A;  1F8C A;  3A71 A;  1N1Y A;  4WA5 A;  2P4O A;  5D9B A;  2F29 A;  4HZV A;  1NNA A;  3SLI A;  1INV A;  1W1X A;  2ZWA A;  4X4A A;  2FLU X;  1N1V A;  4MWX A;  4MX0 A;  2HTQ A;  1B9V A;  2W8B B;  1CRU A;  3S8V A;  4WA4 A;  4SLI A;  4NN9 A;  4CPL A;  4N1B A;  2W8B A;  1NNC A;  4YW5 A;  1IVF A;  1NNB A;  2WOZ A;  4CPM A;  4XIL A;  2ZZK A;  1IVG A;  4XIK A;  4CPZ A;  3ALX A;  3I1C A;  3IAX A;  3OPZ A;  3GVL A;  4M4V A;  3DAS A;  2VK5 A;  1V0E A;  4AGT A;  3AMR A;  2YA4 A;  1XOE A;  3WW9 A;  4XJR A;  3VNG A;  4D8S A;  1V3D A; 
#chains in the Genus database with same CATH homology
 1X2R A;  3WDZ A;  4N1B A;  4YY8 A;  4IQK A;  3WN7 A;  4IFL X;  2WOZ A;  3ADE A;  2VPJ A;  3ZGD A;  4CH9 A;  4IFN X;  1U6D X;  1ZGK A;  5F72 C;  5CGJ A;  2ZZK A;  3VNH A;  1X2J A;  3II7 A;  4ZY3 A;  4IFJ A;  2ZW9 A;  5FNT A;  4L7C A;  4CHB A;  4L7B A;  4ZGC A;  4XMB A;  5FNR A;  3ZGC A;  5FNU A;  2Z32 A;  2ZWA A;  2FLU X;  2DYH A;  5FNQ A;  5FNS A;  4ASC A;  4IN4 A;  5FZJ A;  5FZN A;  3VNG A;  4L7D A;  2XN4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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