5FNS | Genus

Total Genus 70

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	70
sequence length	289
structure length	289
Chain Sequence	GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Transcription
source organism	Mus musculus
publication title	Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. pubmed doi rcsb
molecule keywords	KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
total genus	70
structure length	289
sequence length	289
ec nomenclature
pdb deposition date	2015-11-16

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01344	Kelch_1	Kelch motif

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	5fnsA00

4IFLX 3ZGDA 4YY8A 3ZGCA 5FNUA 2ZZKA 4CHBA 1ZGKA 5F72C 4IQKA 4ZGCA 2FLUX 3ADEA 1X2RA 2WOZA 5FZJA 1X2JA 3VNGA 2VPJA 2ZW9A 4L7BA 1U6DX 2XN4A 3II7A 4ZY3A 4CH9A 5FNQA 4N1BA 5CGJA 4IFJA 4XMBA 5FNRA 4IFNX 4L7DA 4L7CA 3WDZA 3WN7A 4ASCA 4IN4A 5FNSA 5FNTA 2DYHA 2ZWAA 5FZNA 3VNHA 2Z32A
chains in the Genus database with same CATH superfamily

5EO7A 3ZGDA 4YY8A 1SUUA 2VK6A 1USRA 3H71A 4FPFA 1F8EA 4FPHA 3B7EA 4YZ2A 1E8VA 3K38A 2SILA 2XCYA 4GNBA 1XOGA 1A4QA 2HTRA 1CRZA 1NCBN 2FP9A 2F10A 1V3BA 5FNQA 2YA4A 4YW3A 1IVDA 3NSSA 1QBIA 4CPLA 5HUNA 4ASCA 4GZXA 4K3YA 1H6LA 4XHBA 2SLIA 4C1YB 1W20A 1Z4YA 2ISMA 3S8VA 4SLIA 3V64C 2B8HA 1EUUA 1N1TA 1Z4ZA 1SO7A 3SRGA 1C9UA 2DG1A 3A9HA 3NN9A 4MWYA 4O5TA 5HUKA 3O4PA 1V0ZA 2ZW9A 2W5NA 1INFA 4CH9A 1IVBA 2DSOA 2VWDA 3WDZA 4L7CA 4Q6KA 3K3AA 2AGSA 4FZHA 2FPBA 3VNHA 2QWAA 4B7MA 3V65B 2XZIA 2H2UA 1NCAN 1V04A 4NN9A 2VAQA 3GVLA 4FP2A 4GZTA 5EX7A 1DILA 1S0JA 2C4AA 4GJTA 1IVGA 1MS5A 1W21A 4XJQA 2HU4A 4DGRA 2HT7A 1E8UA 4GEZA 4HZWA 1U6DX 2QE8A 3LI5A 1MS0A 2W8BB 3HLHA 5HUMA 4CPZA 5GX2A 2FPCA 2BF6A 1DIMA 4KS3A 4FQ4A 4FPCA 4K1IA 4R40A 4HZXA 2W20A 4GNAA 2ZZKA 1L7GA 1L7FA 2QWFA 4IQKA 1CRUA 5M1ZA 2VK5A 3A9GA 4XYXA 3OPZA 1V3CA 2F29A 3II7A 1NN2A 1CQ1A 4MWUA 2F13A 4FVKA 4M4UA 3LI4A 1NSDA 4IFNX 3H6JA 2OJHA 4YW5A 2HT8A 2JKBA 4GN8A 2F26A 4IFLX 1MR5A 2VSKA 4XIKA 1MWEA 3H73A 4CPOA 3TC9A 3GVKA 2WOZA 3ALXA 5GX4A 3VNGA 4FPJA 1PJXA 2IVZA 2IAVA 4UF7A 4GZPA 2AEPA 4QN6A 3K39A 1V0EA 3WW9A 3G4EA 2ZWAA 3K37A 4XJ8A 3CYEA 4KS1A 3FW0A 1EURA 1NSCA 2QWCA 3Q6PA 4MC7A 1Q7FA 4MWVA 4B7NA 1SLLA 4FOWA 2FLUX 1WCSA 2VW0A 3T1EA 2GVXA 5B2DA 4XJZA 1ZI0A 1W1XA 4NCSA 2QWGA 2VW2A 2AH2A 4QN3A 4MWRA 2IARA 3HLIA 4L7DA 3INBA 1INXA 4GZQA 5D9CA 5FNTA 1USXA 3U0SA 3O9KA 3AMSA 5D9BA 4G3NA 4HZYA 3HRPA 4QN7A 2HU0A 1MZ5A 2AEQA 4K1JA 1NMBN 1INWA 4B7RA 5HX0A 1K32A 3TIBA 1MS3A 1F8DA 3K36A 4I00A 1EUSA 2QWEA 4JMLA 5FNRA 3UC1A 3W09A 2YA8A 1B9TA 4MWQA 4FOYA 2F0ZA 4HW6A 4FJ6A 4XIOA 1VCUA 1N1YA 2Z32A 4AHAA 4X49A 1IJQA 1N7DA 1S0IA 1V0FA 4MWWA 3I1CA 3TI3A 1B9VA 2ZB5A 4M3MA 4QN4A 4HZZA 1MZ6A 4D52A 4FPGA 4AGTA 2A75A 2FP8A 4L7BA 1XOEA 4MJVA 3SREA 5D9DA 4N1BA 2VW1A 2XZJA 3LI3A 1L7HA 1B9SA 1N6FA 2DG0A 1W0PA 5GX1A 5FZNA 1WCQA 4MX0A 2X9MA 4BBWA 3TI6A 3V1SA 4B7QA 4XJWA 2IAQA 4GN9A 5NN9A 2V91A 1N6EA 1MS9A 2YDPA 2F24A 3ADEA 4QNPA 5FWWA 2QWJA 2HTUA 4K1HA 2VK7A 3SLIA 3A72A 1POOA 4XMBA 1N1SA 3GVJA 4FPKA 4YZ1A 3CL2A 3L6VA 2BERA 2GVUA 4FP3A 2DYHA 4GZSA 4B7JA 1NMAN 4XMAA 4DG6A 2IATA 2XZKA 4MWJA 4XJUA 3P5BL 4D8SA 4NC5A 4K1KA 1NSBA 1SNTA 1SLIA 2BATA 2HTVA 1VCJA 4XILA 2H2NA 1W8OA 3NO0A 4CSDA 2HQSA 4Q1UA 4GDJA 1NCDN 2GVWA 3DASA 4PWZA 4J9TA 3SOQA 2QWIA 4O5SA 3TI5A 4WA3A 2YA6A 3SOBB 3Q6KA 4FPYA 1RWIA 3AMRA 5H47A 3SOVA 1MS1A 2YDTA 1WP5A 4YW4A 4KS2A 4ZY3A 5CGJA 1RWLA 4YW2A 3TI8A 4FOQA 2HTWA 1C5KA 1Z50A 2YA5A 4IN4A 4YZ3A 2YA7A 2ZB6A 2P4OA 1IUCA 4FPEA 1MS8A 4HHQA 3S94A 1A14N 1ZGKA 4GZOA 3WWAA 1N1VA 4A0PA 4H52A 1V3EA 4CPNA 4YZ4A 2BZDA 1INVA 1E8TA 4MWLA 2F11A 1E1AA 2W38A 3Q6TA 3E5ZA 4AGIA 4GNCA 4XHXA 2IAPA 4X6KA 1CVMA 1EUTA 4HIZA 2POOA 4IMBA 3SALA 2QWHA 4XJ9A 5FNUA 2F12A 4D52B 4CHBA 2HTYA 5F72C 3TICA 4MWXA 3IAXA 4X4AA 2HTQA 2IAOA 1V2IA 4FOVA 4C1YA 4WEGA 2VVZA 2VSMA 1BJIA 1W8NA 5GX3A 4JF7A 3JU4A 3CL0A 5EO8A 1IVEA 4YZ5A 1OFZA 2CMLA 1A4GA 4FPLA 2GVVA 1Z4WA 1W0OA 1V3DA 1F8BA 2RKCA 2F25A 5GTQA 2IAUA 4KS5A 1MS4A 4X47A 5B2CA 4HHOA 4M4NA 4CPYA 3ZGCA 4UOUA 5HUGA 3FVZA 3DR2A 2GHSA 1NPEA 4XOGA 4XJAA 4XMIA 3PJQA 5F9TA 5FZJA 1X2JA 2C4LA 5JYYA 3O9JA 2XN4A 4XJRA 3TI4A 2SIMA 4WA5A 4IFJA 3KYAA 2QWDA 5FNSA 2F27A 1NMCA 3D11A 4D4UA 3CKZA 1IVCA 1S18A 4XE9A 2IAWA 3TIAA 2W8BA 2IAXA 3SANA 3S2KA 4D52C 2FHRA 4M4VA 1QLGA 4YW1A 5GX5A 4ZGCA 4WEFA 3A71A 4QN5A 2VPJA 4MZAA 4MZEA 4CPMA 4ZLRA 4WA4A 1IVFA 1F8CA 3D12A 1INGA 4KS4A 4GN7A 1NNAA 4H53A 3BEQA 4GZWA 1S1DA 7NN9A 2F28A 2QWKA 4AH4A 1INYA 4HZVA 4MJUA 1INHA 3G4HA 1X2RA 2W5OA 3S8ZA 1N6DA 1NCCN 4FPOB 2HT5A 1NNBA 4GB1A 1IUBA 2G8SA 3B69A 4IYGA 1KITA 3ALWA 6NN9A 3WN7A 1NNCA 1Z4VA 3BYCA 4GDIA 2QWBA 2IASA 3SILA 1Z4XA 3KGGA 3H72A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4IFL X;  3ZGD A;  4YY8 A;  3ZGC A;  5FNU A;  2ZZK A;  4CHB A;  1ZGK A;  5F72 C;  4IQK A;  4ZGC A;  2FLU X;  3ADE A;  1X2R A;  2WOZ A;  5FZJ A;  1X2J A;  3VNG A;  2VPJ A;  2ZW9 A;  4L7B A;  1U6D X;  2XN4 A;  3II7 A;  4ZY3 A;  4CH9 A;  5FNQ A;  4N1B A;  5CGJ A;  4IFJ A;  4XMB A;  5FNR A;  4IFN X;  4L7D A;  4L7C A;  3WDZ A;  3WN7 A;  4ASC A;  4IN4 A;  5FNS A;  5FNT A;  2DYH A;  2ZWA A;  5FZN A;  3VNH A;  2Z32 A; 
#chains in the Genus database with same CATH topology
 5EO7 A;  3ZGD A;  4YY8 A;  1SUU A;  2VK6 A;  1USR A;  3H71 A;  4FPF A;  1F8E A;  4FPH A;  3B7E A;  4YZ2 A;  1E8V A;  3K38 A;  2SIL A;  2XCY A;  4GNB A;  1XOG A;  1A4Q A;  2HTR A;  1CRZ A;  1NCB N;  2FP9 A;  2F10 A;  1V3B A;  5FNQ A;  2YA4 A;  4YW3 A;  1IVD A;  3NSS A;  1QBI A;  4CPL A;  5HUN A;  4ASC A;  4GZX A;  4K3Y A;  1H6L A;  4XHB A;  2SLI A;  4C1Y B;  1W20 A;  1Z4Y A;  2ISM A;  3S8V A;  4SLI A;  3V64 C;  2B8H A;  1EUU A;  1N1T A;  1Z4Z A;  1SO7 A;  3SRG A;  1C9U A;  2DG1 A;  3A9H A;  3NN9 A;  4MWY A;  4O5T A;  5HUK A;  3O4P A;  1V0Z A;  2ZW9 A;  2W5N A;  1INF A;  4CH9 A;  1IVB A;  2DSO A;  2VWD A;  3WDZ A;  4L7C A;  4Q6K A;  3K3A A;  2AGS A;  4FZH A;  2FPB A;  3VNH A;  2QWA A;  4B7M A;  3V65 B;  2XZI A;  2H2U A;  1NCA N;  1V04 A;  4NN9 A;  2VAQ A;  3GVL A;  4FP2 A;  4GZT A;  5EX7 A;  1DIL A;  1S0J A;  2C4A A;  4GJT A;  1IVG A;  1MS5 A;  1W21 A;  4XJQ A;  2HU4 A;  4DGR A;  2HT7 A;  1E8U A;  4GEZ A;  4HZW A;  1U6D X;  2QE8 A;  3LI5 A;  1MS0 A;  2W8B B;  3HLH A;  5HUM A;  4CPZ A;  5GX2 A;  2FPC A;  2BF6 A;  1DIM A;  4KS3 A;  4FQ4 A;  4FPC A;  4K1I A;  4R40 A;  4HZX A;  2W20 A;  4GNA A;  2ZZK A;  1L7G A;  1L7F A;  2QWF A;  4IQK A;  1CRU A;  5M1Z A;  2VK5 A;  3A9G A;  4XYX A;  3OPZ A;  1V3C A;  2F29 A;  3II7 A;  1NN2 A;  1CQ1 A;  4MWU A;  2F13 A;  4FVK A;  4M4U A;  3LI4 A;  1NSD A;  4IFN X;  3H6J A;  2OJH A;  4YW5 A;  2HT8 A;  2JKB A;  4GN8 A;  2F26 A;  4IFL X;  1MR5 A;  2VSK A;  4XIK A;  1MWE A;  3H73 A;  4CPO A;  3TC9 A;  3GVK A;  2WOZ A;  3ALX A;  5GX4 A;  3VNG A;  4FPJ A;  1PJX A;  2IVZ A;  2IAV A;  4UF7 A;  4GZP A;  2AEP A;  4QN6 A;  3K39 A;  1V0E A;  3WW9 A;  3G4E A;  2ZWA A;  3K37 A;  4XJ8 A;  3CYE A;  4KS1 A;  3FW0 A;  1EUR A;  1NSC A;  2QWC A;  3Q6P A;  4MC7 A;  1Q7F A;  4MWV A;  4B7N A;  1SLL A;  4FOW A;  2FLU X;  1WCS A;  2VW0 A;  3T1E A;  2GVX A;  5B2D A;  4XJZ A;  1ZI0 A;  1W1X A;  4NCS A;  2QWG A;  2VW2 A;  2AH2 A;  4QN3 A;  4MWR A;  2IAR A;  3HLI A;  4L7D A;  3INB A;  1INX A;  4GZQ A;  5D9C A;  5FNT A;  1USX A;  3U0S A;  3O9K A;  3AMS A;  5D9B A;  4G3N A;  4HZY A;  3HRP A;  4QN7 A;  2HU0 A;  1MZ5 A;  2AEQ A;  4K1J A;  1NMB N;  1INW A;  4B7R A;  5HX0 A;  1K32 A;  3TIB A;  1MS3 A;  1F8D A;  3K36 A;  4I00 A;  1EUS A;  2QWE A;  4JML A;  5FNR A;  3UC1 A;  3W09 A;  2YA8 A;  1B9T A;  4MWQ A;  4FOY A;  2F0Z A;  4HW6 A;  4FJ6 A;  4XIO A;  1VCU A;  1N1Y A;  2Z32 A;  4AHA A;  4X49 A;  1IJQ A;  1N7D A;  1S0I A;  1V0F A;  4MWW A;  3I1C A;  3TI3 A;  1B9V A;  2ZB5 A;  4M3M A;  4QN4 A;  4HZZ A;  1MZ6 A;  4D52 A;  4FPG A;  4AGT A;  2A75 A;  2FP8 A;  4L7B A;  1XOE A;  4MJV A;  3SRE A;  5D9D A;  4N1B A;  2VW1 A;  2XZJ A;  3LI3 A;  1L7H A;  1B9S A;  1N6F A;  2DG0 A;  1W0P A;  5GX1 A;  5FZN A;  1WCQ A;  4MX0 A;  2X9M A;  4BBW A;  3TI6 A;  3V1S A;  4B7Q A;  4XJW A;  2IAQ A;  4GN9 A;  5NN9 A;  2V91 A;  1N6E A;  1MS9 A;  2YDP A;  2F24 A;  3ADE A;  4QNP A;  5FWW A;  2QWJ A;  2HTU A;  4K1H A;  2VK7 A;  3SLI A;  3A72 A;  1POO A;  4XMB A;  1N1S A;  3GVJ A;  4FPK A;  4YZ1 A;  3CL2 A;  3L6V A;  2BER A;  2GVU A;  4FP3 A;  2DYH A;  4GZS A;  4B7J A;  1NMA N;  4XMA A;  4DG6 A;  2IAT A;  2XZK A;  4MWJ A;  4XJU A;  3P5B L;  4D8S A;  4NC5 A;  4K1K A;  1NSB A;  1SNT A;  1SLI A;  2BAT A;  2HTV A;  1VCJ A;  4XIL A;  2H2N A;  1W8O A;  3NO0 A;  4CSD A;  2HQS A;  4Q1U A;  4GDJ A;  1NCD N;  2GVW A;  3DAS A;  4PWZ A;  4J9T A;  3SOQ A;  2QWI A;  4O5S A;  3TI5 A;  4WA3 A;  2YA6 A;  3SOB B;  3Q6K A;  4FPY A;  1RWI A;  3AMR A;  5H47 A;  3SOV A;  1MS1 A;  2YDT A;  1WP5 A;  4YW4 A;  4KS2 A;  4ZY3 A;  5CGJ A;  1RWL A;  4YW2 A;  3TI8 A;  4FOQ A;  2HTW A;  1C5K A;  1Z50 A;  2YA5 A;  4IN4 A;  4YZ3 A;  2YA7 A;  2ZB6 A;  2P4O A;  1IUC A;  4FPE A;  1MS8 A;  4HHQ A;  3S94 A;  1A14 N;  1ZGK A;  4GZO A;  3WWA A;  1N1V A;  4A0P A;  4H52 A;  1V3E A;  4CPN A;  4YZ4 A;  2BZD A;  1INV A;  1E8T A;  4MWL A;  2F11 A;  1E1A A;  2W38 A;  3Q6T A;  3E5Z A;  4AGI A;  4GNC A;  4XHX A;  2IAP A;  4X6K A;  1CVM A;  1EUT A;  4HIZ A;  2POO A;  4IMB A;  3SAL A;  2QWH A;  4XJ9 A;  5FNU A;  2F12 A;  4D52 B;  4CHB A;  2HTY A;  5F72 C;  3TIC A;  4MWX A;  3IAX A;  4X4A A;  2HTQ A;  2IAO A;  1V2I A;  4FOV A;  4C1Y A;  4WEG A;  2VVZ A;  2VSM A;  1BJI A;  1W8N A;  5GX3 A;  4JF7 A;  3JU4 A;  3CL0 A;  5EO8 A;  1IVE A;  4YZ5 A;  1OFZ A;  2CML A;  1A4G A;  4FPL A;  2GVV A;  1Z4W A;  1W0O A;  1V3D A;  1F8B A;  2RKC A;  2F25 A;  5GTQ A;  2IAU A;  4KS5 A;  1MS4 A;  4X47 A;  5B2C A;  4HHO A;  4M4N A;  4CPY A;  3ZGC A;  4UOU A;  5HUG A;  3FVZ A;  3DR2 A;  2GHS A;  1NPE A;  4XOG A;  4XJA A;  4XMI A;  3PJQ A;  5F9T A;  5FZJ A;  1X2J A;  2C4L A;  5JYY A;  3O9J A;  2XN4 A;  4XJR A;  3TI4 A;  2SIM A;  4WA5 A;  4IFJ A;  3KYA A;  2QWD A;  5FNS A;  2F27 A;  1NMC A;  3D11 A;  4D4U A;  3CKZ A;  1IVC A;  1S18 A;  4XE9 A;  2IAW A;  3TIA A;  2W8B A;  2IAX A;  3SAN A;  3S2K A;  4D52 C;  2FHR A;  4M4V A;  1QLG A;  4YW1 A;  5GX5 A;  4ZGC A;  4WEF A;  3A71 A;  4QN5 A;  2VPJ A;  4MZA A;  4MZE A;  4CPM A;  4ZLR A;  4WA4 A;  1IVF A;  1F8C A;  3D12 A;  1ING A;  4KS4 A;  4GN7 A;  1NNA A;  4H53 A;  3BEQ A;  4GZW A;  1S1D A;  7NN9 A;  2F28 A;  2QWK A;  4AH4 A;  1INY A;  4HZV A;  4MJU A;  1INH A;  3G4H A;  1X2R A;  2W5O A;  3S8Z A;  1N6D A;  1NCC N;  4FPO B;  2HT5 A;  1NNB A;  4GB1 A;  1IUB A;  2G8S A;  3B69 A;  4IYG A;  1KIT A;  3ALW A;  6NN9 A;  3WN7 A;  1NNC A;  1Z4V A;  3BYC A;  4GDI A;  2QWB A;  2IAS A;  3SIL A;  1Z4X A;  3KGG A;  3H72 A; 
#chains in the Genus database with same CATH homology
 4IFL X;  3ZGD A;  4YY8 A;  3ZGC A;  5FNU A;  2ZZK A;  4CHB A;  1ZGK A;  5F72 C;  4IQK A;  4ZGC A;  2FLU X;  3ADE A;  1X2R A;  2WOZ A;  5FZJ A;  1X2J A;  3VNG A;  2VPJ A;  2ZW9 A;  4L7B A;  1U6D X;  2XN4 A;  3II7 A;  4ZY3 A;  4CH9 A;  5FNQ A;  4N1B A;  5CGJ A;  4IFJ A;  4XMB A;  5FNR A;  4IFN X;  4L7D A;  4L7C A;  3WDZ A;  3WN7 A;  4ASC A;  4IN4 A;  5FNS A;  5FNT A;  2DYH A;  2ZWA A;  5FZN A;  3VNH A;  2Z32 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5FNSA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations