5FZJA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 72

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
289
structure length
289
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
source organism Mus musculus
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
total genus 72
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2016-03-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fzjA00
4IFJA 4IFLX 4L7DA 5FZNA 4YY8A 4IN4A 2FLUX 3WN7A 2WOZA 3ZGDA 4L7CA 2DYHA 5FNQA 3VNHA 2ZWAA 1X2RA 3ADEA 1ZGKA 2VPJA 5FNRA 4XMBA 1X2JA 4ZY3A 1U6DX 5FNUA 4ZGCA 4N1BA 5FNTA 4L7BA 2XN4A 5FNSA 5FZJA 3II7A 4CH9A 4CHBA 2ZZKA 2ZW9A 5CGJA 3VNGA 4IQKA 4IFNX 3WDZA 2Z32A 4ASCA 5F72C 3ZGCA
chains in the Genus database with same CATH superfamily
4WA5A 4FPEA 4KS3A 1MZ6A 1NMBN 5F9TA 4M4NA 1SLLA 2HQSA 4WEGA 3TI5A 1INFA 3PJQA 1VCUA 4MC7A 1Z4YA 4AGIA 4D52B 3ALWA 4FP3A 1INWA 1L7GA 2ZZKA 2GVUA 1EUSA 1Q7FA 2F28A 3S8VA 1MS3A 2GVVA 3O9KA 3GVLA 2YDTA 4QN6A 2VSKA 1CRUA 2W5OA 4K1JA 3NO0A 4KS5A 4MWXA 2QWKA 2BF6A 4IMBA 1Z4ZA 1N1SA 3GVKA 1V3EA 3BYCA 4QNPA 4D52C 1NPEA 2HTUA 2B8HA 4C1YB 1RWLA 2CMLA 4CSDA 3Q6TA 3GVJA 3HLHA 2YA4A 3SOQA 2AEQA 4D4UA 1E8UA 2IAUA 2QWJA 2IVZA 2VK5A 4J9TA 3OPZA 3V65B 4JMLA 1NSDA 2W5NA 2HTQA 3WN7A 4MWQA 4XILA 1W8NA 3SOVA 3DR2A 2QWIA 5FNQA 2C4LA 2VAQA 4B7RA 1MR5A 4K3YA 5GTQA 4O5TA 1B9VA 4QN7A 2XN4A 5H47A 4YW2A 2IATA 4X6KA 2HT7A 4CHBA 2GVXA 3V1SA 3A9HA 4GDIA 1IVFA 1L7FA 1E1AA 2AEPA 2Z32A 1IVCA 3SLIA 4IYGA 1NN2A 3W09A 5M1ZA 4FPLA 3ZGDA 2DYHA 4GZXA 2W8BB 3AMSA 5FNRA 2IAQA 1U6DX 3D12A 1INYA 4GZQA 1MS9A 1NCDN 2ZW9A 1WP5A 1SO7A 3V64C 1IJQA 5FZNA 4D8SA 4FZHA 3CYEA 2IAXA 1A4GA 2VSMA 3VNHA 1WCQA 2F25A 1NCCN 2ZB6A 2SILA 4GJTA 4K1IA 4H53A 1IVEA 2F27A 3ALXA 1IVBA 1CVMA 1NNCA 4XJAA 4XMAA 1MS0A 2YA7A 1INHA 1V2IA 2XZIA 4XMIA 2F24A 4DG6A 5HX0A 4IQKA 4FPHA 4FPOB 1POOA 1IVGA 2BZDA 3U0SA 2QWFA 1NMAN 2QWCA 2HTYA 2VW1A 2F26A 1A4QA 4X47A 2HTVA 2IAPA 4Q1UA 2G8SA 1INXA 5FNUA 4XJRA 4FOYA 4GN7A 3BEQA 3SOBB 1Z4VA 4GNAA 3UC1A 4AGTA 3IAXA 4K1KA 5HUGA 1MS1A 4R40A 5EX7A 1B9SA 3S2KA 4L7DA 1K32A 4SLIA 1USRA 1PJXA 1Z4WA 1F8CA 5D9DA 5B2DA 1NNAA 2XZJA 1NSBA 4B7MA 2XCYA 5HUKA 1X2JA 4N1BA 2YA5A 4K1HA 2POOA 1MWEA 2AH2A 4D52A 5FNSA 4HZWA 1CQ1A 3TIBA 1V0ZA 4GDJA 2HU0A 3H72A 3B7EA 4FPFA 1F8DA 1WCSA 1NSCA 4UF7A 3P5BL 3NN9A 2C4AA 4FJ6A 1MS8A 3L6VA 4CPLA 2BATA 2W20A 3CL2A 4HHQA 4QN4A 4XIOA 4MX0A 1W0OA 4XJWA 2IARA 3LI5A 3KYAA 2GHSA 3TI6A 4C1YA 2V91A 5FZJA 4BBWA 1E8TA 4FP2A 2GVWA 4XHBA 3JU4A 4FPGA 4MWLA 4MWRA 4GNCA 3WDZA 4AH4A 3CL0A 1INGA 2HTWA 4CPMA 4WEFA 2IAVA 2RKCA 5GX3A 4XJUA 5GX2A 2VK6A 4HZXA 4MZAA 3K39A 2YA8A 4X49A 4ZLRA 3K38A 2F12A 4QN5A 1W1XA 4G3NA 1F8BA 1RWIA 2HTRA 4MWUA 4NN9A 1QBIA 1SLIA 2VWDA 3K3AA 2BERA 4DGRA 3SRGA 1SUUA 4KS2A 4YZ4A 2ISMA 4MWYA 1SNTA 1QLGA 4YZ3A 1N1VA 3D11A 1C5KA 4YZ2A 1V0FA 1E8VA 1IUBA 4FPJA 4XJ9A 2W8BA 2ZWAA 1X2RA 2IAOA 2VPJA 3LI4A 5HUNA 3CKZA 1W20A 2VW2A 3H6JA 3SILA 1N6DA 5GX4A 1EUUA 4GZWA 1USXA 3TI4A 1V04A 1EUTA 1MZ5A 4XIKA 2F29A 3A71A 4M4VA 1NCBN 1EURA 2YDPA 4MWJA 2IAWA 5CGJA 2FP9A 2X9MA 4MJVA 2QWHA 4NC5A 1L7HA 3HLIA 1Z50A 3S94A 4MWVA 3TICA 2FHRA 5EO7A 1CRZA 3B69A 4FOVA 2IASA 1NCAN 4O5SA 3WWAA 4FOQA 1ZGKA 4QN3A 4FPYA 3O4PA 4XMBA 4ZY3A 3WW9A 1N6EA 1XOEA 4XE9A 2AGSA 1F8EA 1N1YA 4GZTA 1S0IA 4Q6KA 3SANA 1W8OA 4M4UA 1N6FA 3AMRA 3I1CA 4YW5A 1W21A 4KS4A 2QE8A 1ZI0A 1W0PA 2H2NA 3KGGA 3TIAA 1MS5A 5NN9A 3TC9A 5D9BA 4B7NA 1NMCA 2FPCA 4XJZA 2QWEA 1BJIA 1NNBA 3SREA 4XYXA 4GN8A 5FWWA 5GX1A 2W38A 4HIZA 1KITA 1V3BA 2QWDA 4X4AA 4PWZA 2DG1A 3G4EA 4B7QA 4GZOA 3Q6PA 1Z4XA 5F72C 3ZGCA 2A75A 3G4HA 1DIMA 2F0ZA 4IN4A 1N1TA 3NSSA 2QWBA 1B9TA 2P4OA 1OFZA 3FVZA 4H52A 4YZ5A 3TI8A 1N7DA 3Q6KA 5FNTA 5HUMA 2F11A 4CPZA 4UOUA 3II7A 2HT5A 4XOGA 5B2CA 2SLIA 4B7JA 4JF7A 1XOGA 2JKBA 1MS4A 4FVKA 3H73A 4IFJA 1S18A 1H6LA 3DASA 4YY8A 5EO8A 4GZSA 4MJUA 4FPCA 4GNBA 4FQ4A 3HRPA 1INVA 3ADEA 4YW4A 2F13A 2QWGA 2HU4A 1V3DA 2VVZA 1IUCA 2FP8A 3K36A 4GN9A 2HT8A 4HZVA 2ZB5A 3A9GA 4FPKA 6NN9A 4CPYA 2FPBA 3S8ZA 2XZKA 4FOWA 4XHXA 1IVDA 5D9CA 4GZPA 4MWWA 4KS1A 4IFLX 1S1DA 2SIMA 2FLUX 1C9UA 2YA6A 1A14N 4L7CA 4XJ8A 1V3CA 5JYYA 4HZZA 4ZGCA 4I00A 3A72A 4L7BA 3SALA 4YZ1A 4CH9A 4MZEA 2DSOA 3INBA 3LI3A 4NCSA 4CPOA 1V0EA 3T1EA 2QWAA 4HZYA 1VCJA 4A0PA 1DILA 2WOZA 3FW0A 2VW0A 3E5ZA 3K37A 3O9JA 4YW1A 4CPNA 4M3MA 4GEZA 4AHAA 2H2UA 2OJHA 4YW3A 5GX5A 2DG0A 2F10A 3H71A 3TI3A 4HW6A 2VK7A 1S0JA 7NN9A 3VNGA 4IFNX 4WA4A 4HHOA 4ASCA 4WA3A 4XJQA 4GB1A
chains in the Genus database with same CATH topology
4IFJA 4IFLX 4L7DA 5FZNA 4YY8A 4IN4A 2FLUX 3WN7A 2WOZA 3ZGDA 4L7CA 2DYHA 5FNQA 3VNHA 2ZWAA 1X2RA 3ADEA 1ZGKA 2VPJA 5FNRA 4XMBA 1X2JA 4ZY3A 1U6DX 5FNUA 4ZGCA 4N1BA 5FNTA 4L7BA 2XN4A 5FNSA 5FZJA 3II7A 4CH9A 4CHBA 2ZZKA 2ZW9A 5CGJA 3VNGA 4IQKA 4IFNX 3WDZA 2Z32A 4ASCA 5F72C 3ZGCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IFJ A;  4IFL X;  4L7D A;  5FZN A;  4YY8 A;  4IN4 A;  2FLU X;  3WN7 A;  2WOZ A;  3ZGD A;  4L7C A;  2DYH A;  5FNQ A;  3VNH A;  2ZWA A;  1X2R A;  3ADE A;  1ZGK A;  2VPJ A;  5FNR A;  4XMB A;  1X2J A;  4ZY3 A;  1U6D X;  5FNU A;  4ZGC A;  4N1B A;  5FNT A;  4L7B A;  2XN4 A;  5FNS A;  5FZJ A;  3II7 A;  4CH9 A;  4CHB A;  2ZZK A;  2ZW9 A;  5CGJ A;  3VNG A;  4IQK A;  4IFN X;  3WDZ A;  2Z32 A;  4ASC A;  5F72 C;  3ZGC A; 
#chains in the Genus database with same CATH topology
 4WA5 A;  4FPE A;  4KS3 A;  1MZ6 A;  1NMB N;  5F9T A;  4M4N A;  1SLL A;  2HQS A;  4WEG A;  3TI5 A;  1INF A;  3PJQ A;  1VCU A;  4MC7 A;  1Z4Y A;  4AGI A;  4D52 B;  3ALW A;  4FP3 A;  1INW A;  1L7G A;  2ZZK A;  2GVU A;  1EUS A;  1Q7F A;  2F28 A;  3S8V A;  1MS3 A;  2GVV A;  3O9K A;  3GVL A;  2YDT A;  4QN6 A;  2VSK A;  1CRU A;  2W5O A;  4K1J A;  3NO0 A;  4KS5 A;  4MWX A;  2QWK A;  2BF6 A;  4IMB A;  1Z4Z A;  1N1S A;  3GVK A;  1V3E A;  3BYC A;  4QNP A;  4D52 C;  1NPE A;  2HTU A;  2B8H A;  4C1Y B;  1RWL A;  2CML A;  4CSD A;  3Q6T A;  3GVJ A;  3HLH A;  2YA4 A;  3SOQ A;  2AEQ A;  4D4U A;  1E8U A;  2IAU A;  2QWJ A;  2IVZ A;  2VK5 A;  4J9T A;  3OPZ A;  3V65 B;  4JML A;  1NSD A;  2W5N A;  2HTQ A;  3WN7 A;  4MWQ A;  4XIL A;  1W8N A;  3SOV A;  3DR2 A;  2QWI A;  5FNQ A;  2C4L A;  2VAQ A;  4B7R A;  1MR5 A;  4K3Y A;  5GTQ A;  4O5T A;  1B9V A;  4QN7 A;  2XN4 A;  5H47 A;  4YW2 A;  2IAT A;  4X6K A;  2HT7 A;  4CHB A;  2GVX A;  3V1S A;  3A9H A;  4GDI A;  1IVF A;  1L7F A;  1E1A A;  2AEP A;  2Z32 A;  1IVC A;  3SLI A;  4IYG A;  1NN2 A;  3W09 A;  5M1Z A;  4FPL A;  3ZGD A;  2DYH A;  4GZX A;  2W8B B;  3AMS A;  5FNR A;  2IAQ A;  1U6D X;  3D12 A;  1INY A;  4GZQ A;  1MS9 A;  1NCD N;  2ZW9 A;  1WP5 A;  1SO7 A;  3V64 C;  1IJQ A;  5FZN A;  4D8S A;  4FZH A;  3CYE A;  2IAX A;  1A4G A;  2VSM A;  3VNH A;  1WCQ A;  2F25 A;  1NCC N;  2ZB6 A;  2SIL A;  4GJT A;  4K1I A;  4H53 A;  1IVE A;  2F27 A;  3ALX A;  1IVB A;  1CVM A;  1NNC A;  4XJA A;  4XMA A;  1MS0 A;  2YA7 A;  1INH A;  1V2I A;  2XZI A;  4XMI A;  2F24 A;  4DG6 A;  5HX0 A;  4IQK A;  4FPH A;  4FPO B;  1POO A;  1IVG A;  2BZD A;  3U0S A;  2QWF A;  1NMA N;  2QWC A;  2HTY A;  2VW1 A;  2F26 A;  1A4Q A;  4X47 A;  2HTV A;  2IAP A;  4Q1U A;  2G8S A;  1INX A;  5FNU A;  4XJR A;  4FOY A;  4GN7 A;  3BEQ A;  3SOB B;  1Z4V A;  4GNA A;  3UC1 A;  4AGT A;  3IAX A;  4K1K A;  5HUG A;  1MS1 A;  4R40 A;  5EX7 A;  1B9S A;  3S2K A;  4L7D A;  1K32 A;  4SLI A;  1USR A;  1PJX A;  1Z4W A;  1F8C A;  5D9D A;  5B2D A;  1NNA A;  2XZJ A;  1NSB A;  4B7M A;  2XCY A;  5HUK A;  1X2J A;  4N1B A;  2YA5 A;  4K1H A;  2POO A;  1MWE A;  2AH2 A;  4D52 A;  5FNS A;  4HZW A;  1CQ1 A;  3TIB A;  1V0Z A;  4GDJ A;  2HU0 A;  3H72 A;  3B7E A;  4FPF A;  1F8D A;  1WCS A;  1NSC A;  4UF7 A;  3P5B L;  3NN9 A;  2C4A A;  4FJ6 A;  1MS8 A;  3L6V A;  4CPL A;  2BAT A;  2W20 A;  3CL2 A;  4HHQ A;  4QN4 A;  4XIO A;  4MX0 A;  1W0O A;  4XJW A;  2IAR A;  3LI5 A;  3KYA A;  2GHS A;  3TI6 A;  4C1Y A;  2V91 A;  5FZJ A;  4BBW A;  1E8T A;  4FP2 A;  2GVW A;  4XHB A;  3JU4 A;  4FPG A;  4MWL A;  4MWR A;  4GNC A;  3WDZ A;  4AH4 A;  3CL0 A;  1ING A;  2HTW A;  4CPM A;  4WEF A;  2IAV A;  2RKC A;  5GX3 A;  4XJU A;  5GX2 A;  2VK6 A;  4HZX A;  4MZA A;  3K39 A;  2YA8 A;  4X49 A;  4ZLR A;  3K38 A;  2F12 A;  4QN5 A;  1W1X A;  4G3N A;  1F8B A;  1RWI A;  2HTR A;  4MWU A;  4NN9 A;  1QBI A;  1SLI A;  2VWD A;  3K3A A;  2BER A;  4DGR A;  3SRG A;  1SUU A;  4KS2 A;  4YZ4 A;  2ISM A;  4MWY A;  1SNT A;  1QLG A;  4YZ3 A;  1N1V A;  3D11 A;  1C5K A;  4YZ2 A;  1V0F A;  1E8V A;  1IUB A;  4FPJ A;  4XJ9 A;  2W8B A;  2ZWA A;  1X2R A;  2IAO A;  2VPJ A;  3LI4 A;  5HUN A;  3CKZ A;  1W20 A;  2VW2 A;  3H6J A;  3SIL A;  1N6D A;  5GX4 A;  1EUU A;  4GZW A;  1USX A;  3TI4 A;  1V04 A;  1EUT A;  1MZ5 A;  4XIK A;  2F29 A;  3A71 A;  4M4V A;  1NCB N;  1EUR A;  2YDP A;  4MWJ A;  2IAW A;  5CGJ A;  2FP9 A;  2X9M A;  4MJV A;  2QWH A;  4NC5 A;  1L7H A;  3HLI A;  1Z50 A;  3S94 A;  4MWV A;  3TIC A;  2FHR A;  5EO7 A;  1CRZ A;  3B69 A;  4FOV A;  2IAS A;  1NCA N;  4O5S A;  3WWA A;  4FOQ A;  1ZGK A;  4QN3 A;  4FPY A;  3O4P A;  4XMB A;  4ZY3 A;  3WW9 A;  1N6E A;  1XOE A;  4XE9 A;  2AGS A;  1F8E A;  1N1Y A;  4GZT A;  1S0I A;  4Q6K A;  3SAN A;  1W8O A;  4M4U A;  1N6F A;  3AMR A;  3I1C A;  4YW5 A;  1W21 A;  4KS4 A;  2QE8 A;  1ZI0 A;  1W0P A;  2H2N A;  3KGG A;  3TIA A;  1MS5 A;  5NN9 A;  3TC9 A;  5D9B A;  4B7N A;  1NMC A;  2FPC A;  4XJZ A;  2QWE A;  1BJI A;  1NNB A;  3SRE A;  4XYX A;  4GN8 A;  5FWW A;  5GX1 A;  2W38 A;  4HIZ A;  1KIT A;  1V3B A;  2QWD A;  4X4A A;  4PWZ A;  2DG1 A;  3G4E A;  4B7Q A;  4GZO A;  3Q6P A;  1Z4X A;  5F72 C;  3ZGC A;  2A75 A;  3G4H A;  1DIM A;  2F0Z A;  4IN4 A;  1N1T A;  3NSS A;  2QWB A;  1B9T A;  2P4O A;  1OFZ A;  3FVZ A;  4H52 A;  4YZ5 A;  3TI8 A;  1N7D A;  3Q6K A;  5FNT A;  5HUM A;  2F11 A;  4CPZ A;  4UOU A;  3II7 A;  2HT5 A;  4XOG A;  5B2C A;  2SLI A;  4B7J A;  4JF7 A;  1XOG A;  2JKB A;  1MS4 A;  4FVK A;  3H73 A;  4IFJ A;  1S18 A;  1H6L A;  3DAS A;  4YY8 A;  5EO8 A;  4GZS A;  4MJU A;  4FPC A;  4GNB A;  4FQ4 A;  3HRP A;  1INV A;  3ADE A;  4YW4 A;  2F13 A;  2QWG A;  2HU4 A;  1V3D A;  2VVZ A;  1IUC A;  2FP8 A;  3K36 A;  4GN9 A;  2HT8 A;  4HZV A;  2ZB5 A;  3A9G A;  4FPK A;  6NN9 A;  4CPY A;  2FPB A;  3S8Z A;  2XZK A;  4FOW A;  4XHX A;  1IVD A;  5D9C A;  4GZP A;  4MWW A;  4KS1 A;  4IFL X;  1S1D A;  2SIM A;  2FLU X;  1C9U A;  2YA6 A;  1A14 N;  4L7C A;  4XJ8 A;  1V3C A;  5JYY A;  4HZZ A;  4ZGC A;  4I00 A;  3A72 A;  4L7B A;  3SAL A;  4YZ1 A;  4CH9 A;  4MZE A;  2DSO A;  3INB A;  3LI3 A;  4NCS A;  4CPO A;  1V0E A;  3T1E A;  2QWA A;  4HZY A;  1VCJ A;  4A0P A;  1DIL A;  2WOZ A;  3FW0 A;  2VW0 A;  3E5Z A;  3K37 A;  3O9J A;  4YW1 A;  4CPN A;  4M3M A;  4GEZ A;  4AHA A;  2H2U A;  2OJH A;  4YW3 A;  5GX5 A;  2DG0 A;  2F10 A;  3H71 A;  3TI3 A;  4HW6 A;  2VK7 A;  1S0J A;  7NN9 A;  3VNG A;  4IFN X;  4WA4 A;  4HHO A;  4ASC A;  4WA3 A;  4XJQ A;  4GB1 A; 
#chains in the Genus database with same CATH homology
 4IFJ A;  4IFL X;  4L7D A;  5FZN A;  4YY8 A;  4IN4 A;  2FLU X;  3WN7 A;  2WOZ A;  3ZGD A;  4L7C A;  2DYH A;  5FNQ A;  3VNH A;  2ZWA A;  1X2R A;  3ADE A;  1ZGK A;  2VPJ A;  5FNR A;  4XMB A;  1X2J A;  4ZY3 A;  1U6D X;  5FNU A;  4ZGC A;  4N1B A;  5FNT A;  4L7B A;  2XN4 A;  5FNS A;  5FZJ A;  3II7 A;  4CH9 A;  4CHB A;  2ZZK A;  2ZW9 A;  5CGJ A;  3VNG A;  4IQK A;  4IFN X;  3WDZ A;  2Z32 A;  4ASC A;  5F72 C;  3ZGC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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